Human genome editing is here. How should it be governed? – American Medical Association

Gene editing is inexpensive, simple and becoming more widely used inclinical applications.One example is clustered regularly interspaced short palindromic repeats(CRISPR)genome editing, whichis an efficient tool to introduce changes in DNA.Germline editing promises efficiency in eradicating many diseases, but ethical and legal questions persistabout unknown, transgenerational and global consequences.

TheDecember issueof theAMA Journal of Ethics(@JournalofEthics)features numerous perspectives ongoverning human genome editingand gives you an opportunity to earn CME credit.

Articles include:

How Should Physicians Respond When They Learn Patients Are Using Unapproved Gene Editing Interventions?Responding to patients violating U.S.health commerce regulations can be critical when they buy and use unproven interventions.

Using the 4-S Framework to Guide Conversations With Patients About CRISPR.Empathic communication skills help motivate understanding of safety, significance of harms, impact on succeeding generations, and social consequences.

What Should Clinicians Do to Engage the Public About Gene Editing?Clinicians should have a working understanding of gene editing, controversy surrounding its use, and its far-reaching clinical and ethical implications.

How ShouldCRISPRedBabies Be Monitored Over Their Life Course to Promote Health Equity?Transnational monitoring efforts should focus on safety, defining standard of care, and promoting just access to innovation.

In the journalsDecemberpodcast,AMA Senior Policy AnalystSean McConnell,PhDwhose work focuses on genomics and precision medicinediscussesgene editing and CRISPR technology.

ScottJ.Schweikartisa senior research associate for the AMA Council on Ethical and Judicial Affairs and legal editor for theAMA Journal of Ethics. On the podcast, hediscusses what prudent governance requires.

Listen toprevious episodesof the podcast, Ethics Talk, or subscribe iniTunesor other services.

TheAMA Journal of EthicsCME module, Prioritizing Women's Health in Germline EditingResearch,isdesignated by the AMA for a maximum of1AMA PRA Category 1 Credit.

The module is part of theAMA EdHub, anonline platformthat brings togetherhigh-qualityCME, maintenance of certification,and educational contentinone placewithrelevant learningactivities,automated credit tracking and reporting forsome states and specialty boards.

Learn more aboutAMA CME accreditation.

The journals editorial focus is on commentaries and articles that offer practical advice and insights for medical students and physicians.Submit a manuscriptfor publication. The journal alsoinvitesoriginal photographs, graphics, cartoons, drawings and paintings that explore the ethical dimensions of health or health care.

Upcoming issues of theAMA Journal of Ethicswill focus onculture,context andepidemic containment, and onglobal burden of cancer inequality.Sign upto receive email alerts when new issues are published.

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Human genome editing is here. How should it be governed? - American Medical Association