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Category Archives: Transhuman News

Gene Therapy May Restore Sight in People With Rare Blinding Disease

Posted: January 16, 2014 at 6:42 pm

Dennis Thompson HealthDay Reporter Posted: Thursday, January 16, 2014, 2:00 PM

THURSDAY, Jan. 16, 2014 (HealthDay News) -- A new gene therapy that successfully treated a rare eye disease in clinical trials could prove the key to preventing more common inherited causes of blindness, researchers say.

In six male patients, doctors used a virus to repair a defective gene that causes choroideremia, a degenerative eye disease that can lead to complete blindness by middle age, according to a clinical trial report published online Jan. 16 in The Lancet.

Vision improved for all the patients following the gene therapy, and particularly for two patients with advanced choroideremia, said lead author Robert MacLaren of the Nuffield Laboratory of Ophthalmology at the University of Oxford, and a consultant surgeon at the Oxford Eye Hospital, in England.

"In truth, we did not expect to see such dramatic improvements in visual acuity and so we contacted both patients' home opticians to get current and historical data on their vision in former years, long before the gene therapy trial started," MacLaren said in a university news release. "These readings confirmed exactly what we had seen in our study and provided an independent verification."

While choroideremia is a rare disease, affecting about one in every 50,000 people, doctors believe the process used to treat it could be turned toward more common inherited eye disorders, such as macular degeneration or retinitis pigmentosa.

"This is something that we've been trying to accomplish for years in retinal science, and it's very encouraging," said Dr. Mark Fromer, an ophthalmologist at Lenox Hill Hospital, in New York City.

Fromer, who was not involved with the new research, predicted that gene therapy could in the future be used to prevent blindness by fixing defective genes in patients before something like macular degeneration can even take root.

"We'll go from putting a Band-Aid on the lesion to preventing it from happening. This is a new pathway to fix things before they get broken," said Fromer, who is also the eye surgeon for the National Hockey League's New York Rangers

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Gene Therapy May Restore Sight in People With Rare Blinding Disease

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Gene therapy treats blindness

Posted: at 6:42 pm

For patients with choroideremia a rare form of progressive blindness there are no current treatment options that can help stop their visual degeneration. But now a new innovative procedure may be the key.

In a new study published in The Lancet, researchers used a novel gene therapy technique on choroideremia patients, which helped restore some of the sight they had already lost over the years. Gene therapy involves injecting patients with a vital gene that is either missing or defective in their genetic code.

Gene therapy is exciting; its a new type of medicine, lead author Robert MacLaren, a professor at the University of Oxford, told FoxNews.com. And what were doing is it on a very small scale, because were looking at a very straightforward gene to replace.

Caused by a mutation in the CHM gene on the X chromosome, choroideremia causes progressive blindness due to degeneration of the choroid, retinal pigment epithelium and retina. Patients with this disease can start their lives with perfect vision, but eventually start to experience problems with light sensitivity and peripheral vision as they age.

The condition, which affects 1 in every 50,000 people, ultimately leads to the death of the photoreceptor cells in the retina causing complete blindness in middle age.

Its like looking down through a telescope at a small central island of vision, MacLaren explained of the disorder. And by the time theyre in their 40s and 50s, they lose vision completely.

Because choroideremia is caused by a defect in a single gene, MacLaren believed that gene therapy could hold promise for patients with this form of progressive blindness. Additionally, because the cellular degeneration occurs so slowly, the researchers had a large window of opportunity in which they could test their treatment before complete visual loss occurred.

In order to fix the mutation found in choroideremia patients, MacLaren and his colleagues genetically altered an adeno-associated virus (AAV), so that it carried a corrective copy of the CHM gene.

The virus is a small biological organism, and its very good at getting into cells, MacLaren said. But rather than deliver the viruss DNA, weve taken out most of the viral DNA and instead put in the missing gene. So it releases the DNA into the nucleus its a single stranded DNA with the missing [CHM] gene.

The researchers injected their engineered virus into the retinas of six patients between the ages of 35 and 63, all of whom were experiencing different stages of choroideremia. Four of the patients still had good eyesight, though they had almost no peripheral vision, and the other two patients had already started to experience vision loss.

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Elmo has a potty mouth Unnecessary Censorship – Video

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Elmo has a potty mouth Unnecessary Censorship
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Elmo has a potty mouth Unnecessary Censorship - Video

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terrorism deceit and ideas, his … for, cultivating conversion infinite time space – Video

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You are intellectually sequestered. I gave you a place for information and betrayal at: secret, terrorism, censorship, trap, plot, hatred, discrimination, pr...

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Tu protesteaza! Nu te mai lasa mintit izgonit inselat furat sechestrat mutilat! – Video

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Tu protesteaza! Nu te mai lasa mintit izgonit inselat furat sechestrat mutilat!
You are intellectually sequestered. I gave you a place for information and betrayal at: secret, terrorism, censorship, trap, plot, hatred, discrimination, pr...

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Tu protesteaza! Nu te mai lasa mintit izgonit inselat furat sechestrat mutilat! - Video

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Order paranormal video that killed ideas lies scams! – Video

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Censorship – Definition and More from the Free Merriam-Webster …

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Act of changing or suppressing speech or writing that is considered subversive of the common good. In the past, most governments believed it their duty to regulate the morals of their people; only with the rise in the status of the individual and individual rights did censorship come to seem objectionable. Censorship may be preemptive (preventing the publication or broadcast of undesirable information) or punitive (punishing those who publish or broadcast offending material). In Europe, both the Roman Catholic and Protestant churches practiced censorship, as did the absolute monarchies of the 17th and 18th centuries. Authoritarian governments such as those in China, Cuba, Saudi Arabia, and the former Soviet Union have employed pervasive censorship, which is generally opposed by underground movements engaged in the circulation of samizdat literature. In the U.S. in the 20th century, censorship focused largely on works of fiction deemed guilty of obscenity (e.g., James Joyce's Ulysses and D.H. Lawrence's Lady Chatterley's Lover), though periodic acts of political censorship also occurred (e.g., the effort to purge school textbooks of possible left-wing content in the 1950s). In the late 20th century, some called for censorship of so-called hate speech, language deemed threatening (or sometimes merely offensive) to various subsections of the population. Censorship in the U.S. is usually opposed by the American Civil Liberties Union. In Germany after World War II it became a crime to deny the Holocaust or to publish pro-Nazi publications. See also Pentagon Papers.

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What is Censorship?

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Censorship -- the control of the information and ideas circulated within a society -- has been a hallmark of dictatorships throughout history. In the 20th Century, censorship was achieved through the examination of books, plays, films, television and radio programs, news reports, and other forms of communication for the purpose of altering or suppressing ideas found to be objectionable or offensive. The rationales for censorship have varied, with some censors targeting material deemed to be indecent or obscene; heretical or blasphemous; or seditious or treasonous. Thus, ideas have been suppressed under the guise of protecting three basic social institutions: the family, the church, and the state.

Not all censorship is equal, nor does all arise from government or external force. People self-censor all the time; such restraint can be part of the price of rational dialogue. The artist Ben Shahn's poster illustration reads: "You have not converted a man because you have silenced him." Silence can indicate a forced assent, or conversely, it can be contemplative, a necessary part of dialogue that rises above the din of quotidian life.

To understand censorship, and the impulse to censor, it is necessary to strip away the shock epithet value that is attached to the word at first utterance. One must recognize that censorship and the ideology supporting it go back to ancient times, and that every society has had customs, taboos, or laws by which speech, dress, religious observance, and sexual expression were regulated. In Athens, where democracy first emerged, censorship was well known as a means of enforcing the prevailing orthodoxy. Indeed, Plato was the first recorded thinker to formulate a rationale for intellectual, religious, and artistic censorship. In his ideal state outlined in The Republic, official censors would prohibit mothers and nurses from relating tales deemed bad or evil. Plato also proposed that unorthodox notions about God or the hereafter be treated as crimes and that formal procedures be established to suppress heresy. Freedom of speech in Ancient Rome was reserved for those in positions of authority. The poets Ovid and Juvenal were both banished, and authors of seditious writings were punished severely. The emperor Nero deported his critics and burned their books.

The organized church soon joined the state as an active censor. The Biblical injunction, "Thou shalt not take the name of the Lord, thy God, in vain" is clearly an early attempt to set limits on what would be acceptable theological discourse. Likewise, "Thou shalt not make unto thee any graven image" is an attempt to set limits on how the Divine may or may not be represented. (And no one, in any land, should think this is anachronistic. Across the world today, appeals to divinity are common reasons for banning the dissemination of a broad range of materials). Censorship is no more acceptable for being practiced in the name of religion than for national security (which is certainly an acceptable secular substitute for religious rationales in the 20th Century). It only indicates that confronting censorship must always involve confronting some part of ourselves and our common history that is both painful and deep-seated.

Unique historical considerations can also spawn censorship. Perhaps the best example is the "Hasprache" (hate speech) law in Germany. It is illegal, under German law, to depict any kind of glorification of the Nazis or even to display the emblem of the swastika. The law is enforced to the point where even historical battle simulations may not use the actual emblems that were used during World War II (by the Waffen SS, for instance). Significantly, almost all of Germany's close neighbors and allies have similar laws. The questions in Germany and elsewhere in the European Union (EU) form a particularly hard case because of the historical background and because the situation in the EU is fast-moving. That is why this series of snapshots of conditions in various countries and regions will first deal with other areas and levels of censorship and access problems, and then return to the situation in the EU.

In a global context, governments have used a powerful array of techniques and arguments to marshal support for their censorship efforts. One of the earliest, as noted, is the religious argument. Certain things are deemed to be offensive in the eyes of the Deity. These things vary from country to country, religion to religion, even sect to sect. They are mostly, though not always, sexual in nature. The commentaries on the nature of the impulse to be censorious towards sexual expression are too numerous even for a wide ranging project like this. The curious reader is urged to read far and wide in the classic texts to see that the problem of governments and citizens reacting in this way is not a new one. What is new are the potential global consequences.

National security and defense runs a very close second to the religious impulse as a rationale for suppression. While nowhere near as old as the religious impulse to censor, in its more modern form it has been even more pervasive. And while the influence of religion on secular affairs is muted in certain parts of the world, the influence of governments usually is not. It is difficult to think of any government that would forego the power, in perceived extreme circumstances, to censor all media, not simply those that appear online. The question, asked in a real world scenario, is what could be considered extreme enough circumstances to justify such action?

There are also forms of censorship that are not so obtrusive, and that have to be examined very carefully to define. "Censorship through intimidation" can be anything from threats against individuals to a government proposing to monitor all activities online (as in one proposal current at the time of this writing in Russia). If citizens feel their activities online will be screened by governmental agencies in their country, their inclination to engage in expression will be much less than if their government stays away -- the classic "chilling effect."

"Censorship through consensus" is also a real possibility. There are countries where the adherence to a shared social, though not religious, code is a fact of life. Understanding that entails discerning where the boundaries of expression are, and where they might be interfered with in a consensus situation.

Economic censorship is more difficult to define. The Roman essayist Cicero used the immortal phrase "Cui bono?" (Who Profits? -- the ancient version of our "Follow the money."). But numbers may tell only part of the story. In a situation where there is economic censorship, is it isolated or undertaken in conjunction with some type of political censorship? Is there a monopoly within a certain country that is threatened by competition, or a class of oligarchs that is threatened by the emergence of real economic opportunity for smaller firms? Is the economy in a locale more prone to monopolistic arrangements than to genuine competition and innovation?

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Number Of Chinese Microbloggers Fell, Due To Censorship And Competition From Mobile Messaging Applications

Posted: at 6:42 pm

The total number of users of Chinese microblogs, like Sina Corp.'s (NASDAQ:SINA) Weibo, fell from 308.6 million in 2012 to 280.8 million in 2013, according to a report from the government agency China Internet Network Information Center. The agency attributed the 9 percent drop to growing competition from social networking and mobile messaging applications on smartphones, such as WeChat, the Wall Street Journal reported on Thursday.

But another possible cause, which the report does not mention, may be the Chinese governments crackdown on microblogs, which have given many Chinese -- dissidents or just disgruntled citizens -- a platform to voice their opinions on a range of issues, from government corruption and environmental degradation to sports and pop stars. Many controversial news items and topics were widely shared on Weibo; many use the platform to comment before government censors quickly shut them down.

The campaign has led to the warning and arrests of high-profile bloggers and commentators, and many analysts have warned that the crackdown may dampen microblog use.

The report did not specify its data collection methods, or which microblogs were studied. Between June and September of 2013, Sina Corp. said daily active users for its Weibo service, the largest microblogging platform in China, grew 11.2 percent to 60.2 million, and a Sina spokesperson said the numbers in the new report didnt match statistics from the companys most recent earnings. The spokesman added that no organization had been in contact with it about collecting statistics on its user base, according to the Wall Street Journal.

Despite the opaque source of the reports data, it is still a strong indication that users are shifting from Weibo to newer social media platforms using smartphones. At the end of September, WeChat had 272 million monthly active users, more than double of what it had just a year earlier.

Conversely, the report said the total number of Chinese Internet users continued to grow. In 2013, the nation added 54 million users for a total of 618 million users, compared to 564 million in 2012. In addition, 73 percent of Chinese Internet users were getting online access through their mobile phones, and the total number of mobile Internet users rose to 500 million at the end of 2013, from 420 million at the end of 2012, according to the Wall Street Journal.

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Wolf of Wall Street faces cuts, bans

Posted: at 6:42 pm

Leonardo DiCaprio's hit new film The Wolf of Wall Street has hit a censorship wall overseas as film bosses in India, Malaysia, Singapore and Nepal have either demanded major cuts to sex scenes or banned the Martin Scorsese project outright.

Indian censors insisted film bosses cut three scenes before they agreed to a limited release, while the movie has been banned in Malaysia and Nepal, according to The Hollywood Reporter, and a whopping 45 minutes had to be cut from the film before censors in the United Arab Emirates agreed to a release.

A spokesman for the film's production company, Red Granite Pictures, says, "Some of the content in the film makes it difficult in certain territories where they have censorship and can even ban films.

"You try to make a film for a worldwide audience. This is a spectacular movie, all three hours of it. It's a shame that certain countries don't allow art to be screened in its entirety."

The scenes that have upset censors overseas include a gay orgy, Jonah Hill's public masturbation sequence and the opening of the film, which features DiCaprio blowing cocaine into a woman's butt using a straw.

Despite the controversial scenes, The Wolf of Wall Street and its leading man are expected to pick up Academy Award nods when the nominations are announced on Thursday morning.

WENN.com

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