Category Archives: Transhuman News

Synthetic biology, or breaking down life into its basic component parts to create enhanced biological systems, can be likened to writing software that enables life. Or genetic engineering on steroids. Whereas previous technologies may have introduced one, two, or a handful of genes into an organism, synthetic biology allows scientists and engineers at companies such as Ginkgo Bioworks, Fermentome, and Intrexon (NYSE: XON) to rebuild large swaths of an organism's genome -- or create an entirely new genome, and therefore organism -- from the ground up using the best traits offered by nature.

While some are turned off by the idea of tweaking organisms or altering nature, constructing synthetic genomes is akin to taking the building blocks of the physical world (atoms) to produce novel compounds (such as synthetic polymers) that enable the production of enhanced consumer products. Here the building blocks are genes, the novel creations are more efficient genomes and creatures, and the end products are the same everyday items produced from petroleum. The difference is that instead of transforming a petroleum feedstock with high heat and pressure in a chemical refinery, we'll be able to utilize biological pathways in sugar-consuming microbes to produce the same (or better) products in a sustainable and renewable process in a biorefinery.

Although it's easy to understand the applications of the field for the production of fuels and industrial chemicals, such as with the industrial biotech platforms of Amyris (NASDAQ: AMRS) and Solazyme (NASDAQ: SZYM) , understanding and harnessing the power of the genetic information found in nature extends far beyond chemicals. Synthetic biology can be used to make our food safer, give us working copies of broken genes to cure diseases, trick us into forgetting that we're addicted to nicotine, produce safer (and more) marijuana without plants, make agricultural products more efficient than ever before, and much, much more. Let's explore five unbelievable technologies made possible by synthetic biology to ensure we don't sell the field short or fail to recognize its tremendous potential.

1. Microbial factories for everyday productsWhen people say that industrial biotech companies are creating living factories by utilizing biological pathways in sugar-consuming microbes to produce everyday products, I don't think they quite understand the power -- or disruptiveness -- of that statement. Sure, engineers can tinker with genomes to create novel microbes that produce a fuel or high value chemical, but it barely scratches the surface of industrial biotech applications.

Amyris' first commercial-scale facility in Brazil feeds locally grown sugarcane to yeast to create premium fuels, cosmetics, lubricants, fragrances, and more. Image source: Amyris.

Consider that Amyris will be able to produce multiple molecules from the same microbes by simply altering environmental stresses inside its bioreactors. While it would take a continuous fermentation process (rather than a batch process with a defined beginning and end) to reap the full advantages, such microbes could help reduce risk related to scale-up today by introducing novel pathways into an organism that already grows for industrial purposes. Amyris won't be able to make an instant leap to full commercial scale for each new molecule, but it could conceivably do so more quickly.

It's a wild idea in the primitive stages of commercial deployment (multiple-molecule microbes could make their debut in 2014), but the future could be even wilder. As we further our relatively limited understanding of DNA, we'll be able to produce smaller and more efficient genomes that call on the same genes to produce multiple products. By the time we pack our bags for Mars, we'll probably be able to bring along a single test tube containing the ultimate microbial factory capable of producing fuels, pharmaceuticals, food, and polymer resins (for our 3-D printing factories) at the flip of a (genetic) switch.

2. Biosensors for food pathogensWe are surrounded by real-time security and protection systems. The smoke detector in your kitchen rests overhead as you make your morning coffee, you set your home's security system before you leave for work, and once you arrive there your computer reminds you that your antivirus software is out of date. So you may be surprised to know that, despite its importance, there is no comparable system in place for the nation's food system. Luckily, synthetic-biology company Sample6 has developed a solution that will enable food producers to mitigate risks in their production systems, which can reduce brand pressure from any number of potential sources in our fast-paced modern world.

Image source: Sample6.

The best current solution for detecting food pathogens is pretty archaic: Food producers swab equipment, work areas, and food itself, send samples to a lab, and then sit around for several days waiting for results. Most choose to ship product before results are confirmed to maximize shelf life, but on the rare occasion a pathogen is detected, well, it's a logistical nightmare to recall all products that may be associated with a particular production shift. Tests from Sample6 provide results and detect harmful pathogens within the same production shift -- enabling food producers to fix contamination issues quickly and stopping tainted products from entering the food supply. In the future the company will offer similar tests to grocery stores, hospitals and clinics for infectious microbes, and oil and gas companies for water monitoring.

Read more:
5 Unbelievable (but Real) Technologies Made Possible by Synthetic Biology