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Category Archives: Transhuman News

DNA evidence leads to arrest of three men in Fair Lawn

Posted: February 5, 2014 at 11:43 am

Three men have been arrested thanks to DNA evidence that was collected at burglaries that occurred last year.

Detectives from the Fair Lawn Police Department collected DNA at burglaries that occurred in the summer that recently came back to identify the suspects.

Detective Jeff Welsh conducted an investigation on a burglary that occurred on July 16 at a residence on Oak Street. Evidence in the home that helped obtain DNA linked Osvaldo Rodriguez, 38, of Newark, to the burglary, according to a press release from Sgt. Brian Metzler of the Fair Lawn Police Department.

When the DNA match was found Rodriguez was already being held in Bergen County Jail for charges related to an October burglary. Rodriguez was arrested on Oct. 17 after Officer Nicholas Snyder found him on 33rd Street and 12th Avenue in Paterson with proceeds from a burglary that had occurred at a residence on 1st Street.

Rodriguez was charged on Jan. 9 with the second burglary and theft charges, according to police. Bail was set at $50,000.

Detective Peter Yuskaitis arrested Glen Rojas, 26, of Clifton, on Jan. 28 after DNA evidence that was found by the initial officers on scene linked him to a burglary at a residence on 26th Street that occurred on Aug. 12. Rojas was charged with burglary and theft, police said. He was sent to Bergen County Jail on $50,000 bail.

Detective Jeff Welsh arrested George Wayman, 33, of Newark, on Feb. 1 after DNA evidence was found by Welsh that linked Wayman to a burglary at a residence on Oak Street that occurred on July 23. Wayman was charged with burglary and theft, according to police. He was sent to Bergen County Jail on $10,000 bail with a 10-percent option.

The Fair Lawn Police Department is reminding residents to lock their windows and doors on their homes and vehicles to help prevent against burglary and theft to their personal property.

Email: putrino@northjersey.com

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DNA evidence leads to arrest of three men in Fair Lawn

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Eukaryotic Genome – Video

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Eukaryotic Genome
This is a short review over Eukaryotic Genomes (Chapter 19 of Campbell and Reece AP Biology book). It covers DNA structure, gene expression, and a little ove...

By: Muldrow AP Biology

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Eukaryotic Genome - Video

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Marketing Genome Project – Building the Dark Horse Comics Booth at Comic-Con 2013 – Video

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Marketing Genome Project - Building the Dark Horse Comics Booth at Comic-Con 2013
We had a great time at Comic-Con 2013 filming this video showing how the Marketing Genome Project constructs tradeshow booths for it #39;s clients. This video took 4 days to shoot and we used...

By: Pacific Creative Productions

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Marketing Genome Project - Building the Dark Horse Comics Booth at Comic-Con 2013 - Video

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Genome mapping for just $10002232 – Video

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Genome mapping for just $10002232

By: Ali Replogle

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Genome mapping for just $10002232 - Video

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Genome Sequencing: Who Gets to Use the Data?

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Imagine having a child and knowing at birth what diseases he or she will face in life.

Its an ethical conundrum for parents: would you even want to know? This knowledge sounds almost too futuristic, and in many ways it is. But experts say genome sequencing technology is rapidly advancing and becoming less expensive, and it could shape the way we approach preventative care and the insurance industry.

Today, parents can receive newborn screens that check for diseases that need to be treated in infancy as well as genetic testing during early pregnancy that identify possible abnormalities.

The current cost of a complete genome sequencing using blood and saliva comes with a price tag of about $1,000, according to Jeffrey Kahn, deputy director for policy and administration at the Johns Hopkins Berman Institute of Bioethics.

It takes a few hours to produce now. As that gets faster and cheaper, it becomes something that is on a scale where it is almost worthwhile to do for everyone, Kahn says. It would be a big change, moving from that newborn screen to doing full genome sequencing on every child that is born.

But having access to a childs sequence today doesnt mean much. In fact, Kahn likens it to having all of the telephone numbers in the white pages without the names. The sequence would have to be run through software that could pick out certain gene mutations to determine predispositions.

The question then is: who should access this data, and for what purposes? he says.

Interpretation

In 2013, the Food and Drug Administration warned Google-backed (NASDAQ: GOOG) 23andMe to stop selling its $99 genetic tests sold at retailers because it had not received regulatory clearance. The FDA says products that are designed to diagnose or prevent disease are technically medical devices and need regulatory approval.

Misha Angrist, assistant professor at the Duke Institute for Genome Sciences & Policy, says the biggest bottleneck within the industry is interpretation.

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Genome Sequencing: Who Gets to Use the Data?

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Genome sequencing highlights risks of diseases

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By Erinn Hutkin, Special to U-T San Diego 6 a.m.Feb. 4, 2014

Last year, actress and activist Angelina Jolie made headlines when she wrote an op-ed piece for the New York Times about why she chose to have a double mastectomy after undergoing a $3,000 genetic test showing she inherited faulty versions of the BRCA1 gene.

Her mother died of breast cancer at a relatively young age, and the test was an indicator that Jolie had a high risk of developing breast cancer in her lifetime.

Its just one example of how technology has allowed many people both high-profile and everyday Joes to learn more about their risks of developing genetic diseases through genome sequencing.

Sequencing is a laboratory process that uses a sample of a persons blood to help determine the DNA sequence of their genomes. DNA is passed down from a persons parents, and the testing can spot abnormalities or disorders that point to a high risk of developing certain genetic diseases, such as breast cancer, or rare disorders, such as Huntingtons disease.

The testing can be used to help doctors pinpoint the causes of certain disorders. It can also be used for cancer patients to make treatment more targeted and specific.

It does have an impact in helping doctors and patients make better decisions about their choices, said Dr. Mark Erlander, chief scientific officer at San Diego-based Trovagene Inc.

In the clinical world, he said, there are two main ways that sequencing is used.

The first is called germ-line sequencing, which he said is done to try to understand if a person is predisposed to certain diseases or disorders Alzheimers, for instance or the BRCA gene thats been linked to breast cancer.

When doing the sequencing, whats being looked for is an association or links, he said. He said this type of testing is typically done on people who are healthy but want to see if the risk of developing a certain disease is elevated.

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Two papers unraveled the mystery of sex determination and benthic adaptation of the flatfish

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Researchers from Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, BGI-Shenzhen and other institutes have successfully decoded the first genome of a flatfish -- half-smooth tongue sole (Cynoglossus semilaevis), providing insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle. The data generated in this project also lay foundation on the genetic breeding of tongue sole. The latest study has been published online today in Nature Genetics. In another study published in Genome Research at the same time, the researchers also uncovered the epigenetic mechanism underlying the temperature-dependent sexual reversal as well as the trans-generational inheritance of such sexual reversal phenomena in tongue sole.

The genetic mechanisms underlying sex determination as well as the origin and evolution of sex chromosomes have fascinated biologists for decades. Half-smooth tongue sole is an important cultured marine flatfish along China coast, whose sex is primarily determined by the inheritance of sex chromosomes (genetic sex determination, GSD) but also affected by environmental temperature (environmental sex determination, ESD). In normal condition, the sex of tongue sole is determined by the ZW/ZZ sex determination system with female containing a heteromorphic W chromosome. However, if juvenile fish are reared in high temperature, the genetic females (ZW) can develop into phenotypic males (so-called pseudo-males). Interestingly, these sex-reversed pseudo-males are fertile and can mate with normal females to produce viable offspring. Astonishingly, most of their genetic female offspring (ZW) develop into pseudo-males, but without temperature induction. Thus, with its complex sex determination system governed by the interaction between genetic determination and environmental factors, tongue sole is an excellent model to understand the molecular mechanism of sex determination in fishes and the interplay of genome and environment.

In this study, the researchers sequenced and assembled the genomes of one male (ZZ) and one female (ZW) tongue sole, respectively. Based on the difference of sequencing depth of Z/W linked-scaffolds between female and male, together with the high-resolution genetic map constructed by SSR and SNP, they assembled the Z and W chromosome of tongue sole at high quality. Using the Z-W homologous genes, they estimated that the age of the tongue sole sex chromosome pair is relatively young (about 30 million years), which contrasts with the age of hundreds of millions of years for the mammalian and avian sex chromosomes. Interestingly, researchers found that the sex chromosomes of tongue sole are derived from the same ancestral vertebrate protochromosome as the avian W and Z chromosomes. Furthermore, the same gene on the Z chromosome, dmrt1, which is the male-determining gene in birds, showed convergent evolution of features that are compatible with a similar function in tongue sole.

To understanding the regulatory mechanisms involved in the temperature-dependent sex reversal as well as the inheritance of sex reversal in tongue sole, researchers then analyzed the gonadal DNA methylomes and transcriptomes of normal males (ZZ), pseudo-males (ZW), normal females (ZW), and the offspring of a pseudo-male crossed with a female. They found that, after phenotypic sexual reversal, the genome-wide methylation patterns of genetic females have been accurately shaped to the patterns of normal males. Furthermore, the methylation changes after sex reversal were enriched in genes in the sex determination pathway. By comparing parental and offspring samples, researchers also found that the methylation changes between parental pseudo-males and females were inherited by offspring pseudo-males, probably explaining why the offspring genetic females of pseudo-males can undergo sexual reversal without temperature induction. For organisms with sex chromosomes, a challenge for the sex-reversed individuals is the unequal gene dosage on sex chromosomes when compared with normal individuals. For example, pseudo-males (ZW) of tongue sole lack one Z chromosome compared with normal males (ZZ), and contain one extra W chromosome with female-specific genes. Thus, how to revolve gene dosage inequality on sex chromosomes is a fundamental question for sex reversal. Researchers found that, dosage compensation only occurs in a restricted, methylated cytosine enriched Z chromosomal region in pseudo-male testes, achieving equal expression level in normal male testes. Some spermatogenesis-related genes were found in this region. For the W chromosome, they observed that many W-linked genes are still actively expressed in pseudo-males. The researchers speculate that the expression of these W-linked genes may compensate the dosage of their counterparts on the Z chromosomes. However, female-specific genes, such as figla, were suppressed in pseudo-males by methylation regulation. In conclusion, the researchers propose that epigenetic regulation plays multiple crucial roles in sexual reversal of tongue sole fish.

Flatfish are characterized by a transition from pelagic to benthic habitats when they metamorphose from free swimming larvae to bottom-dwelling fish, accompanied by a series of biological and phenotypic changes, such as eye migration, displacement of internal organs, the difference of pigmentation and the sensitivity of light. By comparing the transcriptomes of pelagic and benthic fish, the researchers revealed that the differentially expressed genes between these two developmental stages are enriched in genes potentially involved in adaptation to a benthic lifestyle. They also identified 15 positively selected genes, which have putative roles in metamorphosis. In addition, they found that the expression levels of rod pigment (rh1) and cone pigment (lws1) genes, which are responsible for scotopic vision and long-wavelength-sensitivity, respectively, were significantly up-regulated in benthic stages, whereas the expression of the middle-wavelength-sensitive pigment gene (rh2) was significantly up-regulated in pelagic stages. Moreover, they also found that several crystallin genes were lost or became pseudogenes. They speculate that these changes reveal the adaptation of the tongue sole visual system after shifting to the benthic environment with weak light conditions. As compensation, tongue sole have developed a strong lateral -line sense organ and especially, the papillae-a specific mechanoreceptorsense organ during evolution.

Dr. Guojie Zhang, who is the leading author of both papers from China National Genebank of BGI, said: "The evolution of sex is one of the major transitions in evolution, that has significantly enhanced the adaptation ability of the species. However, our knowledge of sex determination mechanisms is still very limited. Vertebrates have various sex-determination mechanisms. The sex determination process of many vertebrate species is regulated by environmental cues, like temperature. Investigation of the molecular mechanisms underlying this process will shed new lights on the understanding of the interaction between functional gene networks and their regulations by environmental factors, and increase our knowledge on how genome evolution drives species diversification and diversity."

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The above story is based on materials provided by BGI Shenzhen. Note: Materials may be edited for content and length.

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Human Circuit Provides City of Rockvilles Television Station with Design and Integration of a Custom Portable Video …

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Gaithersburg, MD (PRWEB) February 05, 2014

For more than fourteen years Human Circuit has been working on projects and upgrades for this local government TV station. This project is an extension of the Rockville 11 master control, post production, and production control systems upgrade that recently updated the channels aging technical infrastructure and provided the path for high definition workflow.

Based on Rockville 11s request to bring its field production capabilities in line with its inhouse production quality, Human Circuit provided a mobile production system that utilizes cellular-based video transmission. The LiveU - LU70 System will help Rockville 11 with live remote field production which they were unable to accomplish before. This is a powerful addition to the current Rockville 11 production environment, allowing live event coverage from virtually anywhere in the city.

Bruce Kaufmann, President and CEO of Human Circuit said; We are huge proponents for cellular bonding technology that provides our broadcast clients with remote capabilities. We have enjoyed a great and long-standing relationship with the City of Rockville and their staff, who trusted our endorsement of this technology. This effort will give them a compact solution for more complete production coverage of their city.

Aaron Dawkins, Acting Station Manager at Rockville 11 stated; Human Circuit is always very sensitive to our needs. Thats why we've worked with them continuously for many, many years. They listen and let us bounce ideas around with the goal of solving our problems, not selling us equipment. We rely on them for their advice and trust heavily in their recommendations.

Rockville 11 is the official award-winning government channel of the City of Rockville that presents programs on Comcast, Verizon and RCN channel 11, as well as 24/7 online streaming via the Citys website. Rockville 11 helps citizens connect with their city by providing programming that includes news, live public meetings and special features highlighting the Citys neighborhoods and residents.

About Human Circuit Since 1965, Human Circuit has been a company of proven creative thinkers who are dedicated to providing technology integration solutions to clients in need of advanced video, audio, data and control systems for use in communications, training, broadcast, streaming, video on demand and presentation applications. With an engineering- and IT-centric core, Human Circuit designs and architects intuitive solutions that are aligned with a company's business objectives, anticipated growth and user needs. Visit http://www.humancircuit.com for more information and a portfolio of our work.

Human Circuit enjoys a reputation as one of the top integrators in this industry due to several factors which include; longevity in the business and the experience that this 47 year history brings. They have an excellent understanding of the latest in technology solutions and provide, and a year-in year-out consistency in quality of work to their customers. They bridge the difficult gap between those who produce technology and those who need to use it.

Their extensive portfolio includes work for federal and state government entities, broadcast and television production studios, command and control centers, training facilities, distance learning centers, corporations and professional organizations, institutions of higher education, medical and healthcare facilities and entertainment and sports venues.

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Eczema Cures Without a Prescription – Video

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Eczema Cures Without a Prescription
Click Here: http://www.VanishEczema.net | Eczema Treatment. How to Get Rid of Eczema Cure eczema with a natural treatment for Eczema that dosn #39;t use chemical...

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Eczema Cures Without a Prescription - Video

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Eczema Treatments For Adults – Video

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Eczema Treatments For Adults
Click Here: http://www.VanishEczema.net | Eczema Treatment. How to Get Rid of Eczema Cure eczema with a natural treatment for Eczema that dosn #39;t use chemical...

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