Category Archives: Human Longevity

Adele is a global superstar, with her amazing voice earning her an Oscar, 15 Grammys as well as multiple world records. Its clear that shes a successful woman, and we all know it. However, the soulful singer has been making headlines lately, not because of her unmatchable talent, but because of her visible weight loss.

Her weight loss was first noticed last year at musicians Drakes birthday bash on October 25 but its her most recent social media post that has got fans talking. Making her first Instagram post of 2020 where she thanked essential workers during the coronavirus pandemic as well as gave thanks for her birthday well wishes, fans were surprised at her weight loss. In the past, Adele once revealed to People Magazine that shed refuse to work with anybody who had an issue with her weight, stating: Even when I was signing a contract, most of the industry knew if anyone ever dared say: Lose weight to me, they wouldnt be working with me.

Adele has yet to publicly discuss her weight loss, and she really has no reason to. The fact of the matter is, Adele is a beautiful and talented woman, regardless of how she looks and what she weighs. Her weight loss pales in comparison to the other incredible things that shes achieved in her young life, and it really shouldnt be framed as the most incredible thing shes done in recent memory. That said, for those on a weight loss journey, they are curious as to how the star did it.

In addition to her incredible figure, fans also noticed that the singers face also looked a little different.

As a result of her weight loss, Adele has lost volume and fat in her face. As a result, her features have become more prominent with her jaw and bone structure appearing sharper and more chiseled. Additionally, its clear that she changed up her diet as she appears to have a much healthier glow. The fact is, your skin is what you eat and when you consume a nutrient-dense diet rich anti-oxidants, your skin will definitely thank you for it.

The seventh most Googled diet in 2019, its clear thats theres some buzz surrounding The Sirtfood diet, and with Adeles weight loss, the buzz is certain to grow.

The Sirtfood diet was created in the United Kingdom by nutritionists Aidan Goggins and Glen Matten, after they published a guide and a recipe book in 2016. The diet focuses on sirtuins, a group of seven proteins found in your body that help to regulate a variety of functions, which include preventing cell death, regulating metabolism, inflammation, as well as the aging process. The diet requires one to consume foods rich in sirtuins, known as sirtfoods, in an effort to activate the sirtuins that will boost fat burn and speed up metabolism.

As mentioned, the Sirtfood Diet encourages the consumption of foods that contain Sirtuins. These Sirtfoods are nutrient-dense and healthy to eat regularly. They include:

Photo by Jim Smeal/Shutterstock (8344889me)Adele59th Annual Grammy Awards, Arrivals, Los Angeles, USA 12 Feb 2017

The diet is broken down into two phases, and if you should do it whenever you feel that you need a bit of a weight-loss boost.

This phase lasts for seven days and its also split up. For the first three days, youre limited to a total of 1000 calories a day. Your diet consists of three Sirtfood green juices (containing kale, arugula, parsley, celery, green apple, lemon juice, and green tea) and one Sirtfood-rich meal. A mean can include miso-glazed tofu, the Sirtfood omelet, or a shrimp stir-fry with buckwheat noodles.

On days four through seven, youll then allowed two green juices and two daily meals for a total of 1,500 calories a day.

Phase one is aimed at jump-starting your weight loss (apparently, youre expected to lose 7 pounds during phase one). The diet does recommend that you stop exercising, or at least cut back on your usual fitness routine during this period as you wont be taking in many calories.

The second phase lasts for two weeks and it is known as the maintenance phase. Its purpose is to encourage weight loss in a steady, sustainable, and manageable way.

There is no calorie limit but you are encouraged to eat three balanced meals that are rich in Sirtfoods, as well as drink one green juice, during this phase. The meal recipes include soy yogurt with berries and stir-fried prawns with kale and buckwheat noodles.

Once youre done with the phases, you can continue with the Sirtfood diet, all you have to do is tweak your meals a bit, and include as many Sirtfoods as possible. Additionally, once youve adopted the Sirtfood lifestyle, youre encouraged to stay active.

Considering the fact that youre consuming way fewer calories than usual, yes, youll probably lose weight adopting this diet. However, whether this particular method is healthy is debatable. This is because super-restrictive eating is rarely healthy or sustainable.

If you consider the fact that 1,000 calories per day is only appropriate for a child between the ages of 2 and 4, I wouldnt exactly call this diet plan healthy. Yes, the diet may enable weight-loss, but living on this kind of calorie restriction for too long would be questionable.

Yes, theres no denying that the foods in the Sirtfood diet are good for you. Plenty of research has shown that green tea, turmeric and even dark chocolate can provide the body with a number of health benefits that include reduced risks of heart disease, diabetes and other inflammation-related diseases. However, actual research into the long-term benefits of increased sirtuin levels in humans is still in its early stages. Additionally, calorie restriction is not how you want to be living your life.

Yes, Adele looks amazing but if she is following the Sirtfood diet, shes more than likely tweaked it in a manner that is sustainable and safer for her health. That said, its advisable that you reach out to a certified dietitian and get their thoughts. Our bodies are each different, and adopting this particular diet does not mean that youll get Adele-results.

According to the Daily Mail, the singer has taken up Reformer Pilates after being introduced to it by close friend Ayda Field, X Factor judge and wife of singer Robbie Williams.

We already know that Pilates is a great exercise for the body, and the same can be said for Reformer Pilates. Reformer Pilates is a more technical version of regular Pilates, requiring practitioners to do Pilates moves on special machines, using ropes, springs, and a carriage. The exercises provide a high intensity yet low-impact full-body workout. Reformer Pilates helps to improve posture, strength, and flexibility as well as build a stronger core and tone your muscles.

Adele has never shied away from being herself and being confident in her skin. While the star is known for her heart-wrenching ballads, its clear that self-love is a huge priority of hers. Last year, Adele celebrated her 31st birthday, and she shared an Instagram post that hinted at prioritizing self-love.

For the first time in a decade, Im ready to feel the world around me and look up for once. Be kind to yourself, people, were only human, go slow, put your phone down and laugh out loud at every opportunity, she shared. Learning to REALLY truly love yourself is it, and Ive only just realized that that is more than enough.

It may hard to do, especially during these times, but self-love can do wonders for your health. Aside from making you happier, research published in the Health Psychology journal found that self-love can help you make better decisions about your health.

Whats more, a separate study published in the Psychological Science journal found that recently divorced individuals who were kinder to themselves were better at bouncing back in the months following the separation than those who regularly self-criticized. Considering the fact that the award-winning singer is currently going through a divorce, its safe to say that shes definitely practicing a lot of self-love.

He, Y.; Yue, Y.; Zheng, X.; Zhang, K.; Chen, S.; Du, Z. (2015). Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?Molecules.20, 9183-9213.

J Clin Hypertens(Greenwich).2014;16:101106. DOI:10.1111/jch.12223.

Shuang, Z., Xiaoqiang, T., Hou-Zao C. (2018). Sirtuins and Insulin Resistance. Frontiers in Endocrinology. 9. https://www.frontiersin.org/article/10.3389/fendo.2018.00748

Sirois, F. M., Kitner, R., & Hirsch, J. K. (2015). Self-compassion, affect, and health-promoting behaviors.Health Psychology, 34(6), 661669.https://doi.org/10.1037/hea0000158

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Adele: Three Secrets Behind Her Incredible Weight-Loss - Longevity LIVE

Dont touch your face."Avoid hugging." Stand 6feet apart."

So many rules about preventing the spread of the coronavirus warn against touching other people. For the last two months, grandparents have been advised against holding their grandchildren while sick patients cannot grasp a relatives hand.

What kind of effect does this lack of human touch haveon people?

Related:COVID-19 interrupts fertility plans for hopeful couples in the United Kingdom

Amanda Whitlock, 39, a photo editor in Chicago, describes herself as a natural introvert. She lives on her own, with her cat Mr. B, and a newly adopted kitten and says shes usually very content in her own company. Whitlock went into a self-imposed lockdown in early March and hasnt had any physical contact with another person since. She says its all starting to get to her.

"I'm someone that has anxiety anyway. The last few days, I think it's really been pretty heavy on me. You know, it would be nice to be able to go out and hang out with someone and hold their hand. You know, something as simple as that, she said.

Theres a good reason why Whitlocks anxiety is on the rise. Studies show physical contact with other people reduces feelings of stress. British evolutionary psychologist and professor Robin Dunbar says it can all be traced back to our monkey ancestry. Grooming each others fur is how apes build friendships. Humans have substituted that grooming with stroking and cuddling, he says and that act of physical touch has a profound effect on our health.

Related:Mourning in the midst of a pandemic

Not only does [touch]build friendships directly and indirectly, but those friendships have a dramatic effect on your well-being, your general health, your ability to recover from illnesses and even your longevity.

"Not only does it build friendships directly and indirectly, but those friendships have a dramatic effect on your well-being, your general health, your ability to recover from illnesses and even your longevity.

Its too early to tell whether the absence of human touch during the pandemic will have long-term consequences. Some groups are particularly vulnerable, like older people living alone, Dunbar says. Playwright Eve Ensler, who now goes by the name V, is worried about how the virus is changing the way we view our bodies. She fears that people are linking human touch with illness.

I think there's something about going out and seeing people being afraid of each other and afraid of each other's bodies.Touch is becoming something equated with sickness and death, and that scares me deeply."

I think there's something about going out and seeing people being afraid of each other and afraid of each other's bodies.Touch is becoming something equated with sickness and death, and that scares me deeply, she said.

The pandemic reminds V of the 1980s when the AIDS virus first became known. Fear of contracting HIV changed attitudes toward sex, and she worries the coronavirus will alter our behavior, too.

[AIDS] definitely changed our relationship to sex and to freedom.Drastically. I so don't want COVID-19 to do this to our relationship to touch. That would be a huge loss for human beings, she said.

Sexual intimacy is off the tablefor many people right now. But for some in the sex industry, its business as usual. Charlotte Rose, an advocate for sex workers in Britain,says many in the industry are still working because theyre not entitled to government support.

There is a large percentage that are still working because they can't claim benefits.A lot of sex workers especially migrant sex workers arent eligible either. So, unfortunately, people are still offering skin-on-skin contact.

Rose used to work in the industry and many of her clients had disabilities. She says for them, it was often not just about sex, but about simple physical contact with another person.

For probably about 90% of my clients,it wasn't even about the intercourse side of it, it was just skin-on-skin contact.I mean, I was predominantly seeing people with disabilities. And, you know, they're already a very marginalized and vulnerable group, and they're the ones that are suffering incredibly at this particular time, she said.

Rose has maintained contact with some of those clients and says a number of them are really struggling with social isolation right now.

Related:Many people arent putting love on hold during COVID-19

Sports and remedial massage therapist Ruth McKinnon knows the importance of human touch in her work, too. Originally from Toronto, McKinnon moved to London in 2017 and began working as a registered massage therapist in the citys financial district.

While many of her clients had physical injuries, McKinnon says theres no question that stress is what brought a lot of people to her clinic. A massage fires up the dopamine in the brain, helping you to relax and ultimately sleep better, she says. But McKinnon hasnt been able to work since mid-Marchwhen the British government announced that all clinics must close because of the pandemic.

McKinnon says shes feeling the effect of the lack of physical contact, too.

Even for myself, not having that regular touch with lots of different people is hard. My husband has noticed an increased amount of touching that I'm doing with him. It's so vital, she said.

McKinnon has no idea when her clinic will open again, but is hopeful she will be able to get back to work soon even if it means wearing protective clothing.

In the meantime, its not all gloom. There are some things you can do to ease the skin hunger you may be feeling. Professor Dunbar says connecting with someone over Skype or Zoom doesnt compare to a good hug but it helps. He jokes that its probably why we have these enormous great white eyeballs."

Theres something about being able to stare into the whites of other people's eyes that seems to be really important in creating that sense of intimacy. On Skype, you stare into the eyeballs and you can see the smile breaking on their face before you even finish the punchline of the joke you're telling them, he said.

In Chicago, Whitlock has been FaceTiming a man she met through a mutual friend. They havent been on a real-life date yet. This week, theyre planning to act out Shakespeares "The Tempest" together on FaceTime. But Whitlock says she longs for the day they can meet in person.

I would love to be able to text him and be like, Hey, let's meet up. Or, you know, since we can't really go anywhere, lets find a safe way in one of our places to meet. That would be awesome, she said.

But Whitlock says she doesnt think its going to happen anytime soon. For now, its just Mr. B and SP, her two cats that are keeping her company.

I think that if I didn't have my pets they're my family. If I didn't have them, I would definitely be climbing the walls right now for some human contact.

Original post:
Human touch is essential. How are people coping with skin hunger? - The World

There are No 1 pop songs you hear everywhere you go and soon hope never to hear again; and then there are pop songs that, to quote the critic Robert Christgau, actually reveal themselves to you in that kind of saturation. Nearly 20 years ago, he gave the examples of the Backstreet Boys I Want It That Way and Chers Believe songwriting so irresistible, it withstands not only play after play but years of changing tastes and production.

Call Me Maybe is another song you are still glad to be reminded of, even after hearing it a gazillion times. As Justin Bieber tweeted to his many millions of Twitter followers, after hearing it on Canadian radio in late 2011: it is possibly the catchiest song Ive ever heard lol. His endorsement prompted his manager, Scooter Braun, to sign the artist, one Carly Rae Jepsen then best known as the third-place runner-up on 2007s Canadian Idol.

Bieber had never jumped out and promoted an artist like this before, Braun told Rolling Stone. Months later, in April 2012, Bieber still hadnt got Call Me Maybe out of his head. A video of him larking about and miming the lyrics with then-girlfriend Selena Gomez, Ashley Tisdale and a host of other tweenage celebrities went viral. Their enthusiasm was as infectious as the song, inspiring everyone from Katy Perry to US armed forces in Afghanistan to follow suit.

You could not have planned Call Me Maybes path to No 1 better had you tried. Within weeks it had hit the top spot in 16 countries with more than 10m copies sold and 355m views on YouTube. It was the kind of rocket-fuelled, felicitous ascent that today might suggest an industry plant but social medias instant embrace of Call Me Maybe was organic and real, a human response to something so moreish.

On first listen, the song seemed deceptively featherweight. The strings sound like ringtones; the guitar parts as though they were lifted from a PlayStation 2 game. But even the most synthetic production cant detract from songwriting this ironclad. It is telling that Call Me Maybe was intended as a folk song; it would be catchy played on a kazoo, or underwater.

Its power lies in its compulsive karaoke quality: you cant sing along to the chorus without also twirling your finger at your temple and miming a phone. And at three minutes and 13 seconds, it leaves you wanting more, and more until you eventually succumb to the repeat button.

But most of Call Me Maybes charm has to do with its singer. At 26, Jepsen was older than most pop stars are at the time of their breakout hit, and certainly past the point of thinking an exchange of phone numbers crazy but she buys into the bubblegum romance with such enthusiasm and warmth, and what could be corny is purely endearing.

It speaks to persistent snobbishness about mainstream pop that Call Me Maybe is often spoken of today as a novelty record or guilty pleasure, rather than as an enduring classic. But its precisely the songs candy-floss lightness that has sustained its longevity. Even when Jepsen achieved indie cred with her 2015 album Emotion, it wasnt with the sense of now this is the music Ive always wanted to make. Now 34, she continues to perform Call Me Maybe with the same infectious delight as she gave it a decade ago. And why wouldnt she? Its still every bit as good.

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The 100 greatest UK No 1s: No 20, Carly Rae Jepsen Call Me Maybe - The Guardian

Restrictive measures aimed at curbing the new coronavirus pandemic have changed the lives of people all over the world in drastic ways. For this Special Feature, we have asked readers and contributors to share their best coping strategies.

People from all over the world have been reporting that current restrictive measures taken in response to the COVID-19 pandemic have significantly altered the daily course of their lives.

In April, dozens of respondents told Medical News Today about the impact the current public health emergency has had on the well-being of themselves and their loved ones.

But what are people doing to cope? A survey from March, 2020 indicates that in the United States, at least, many individuals have turned to unhealthful coping strategies, such as increased alcohol consumption or the use of other recreational substances.

The same survey also suggests that a majority of U.S. respondents were actively seeking to improve their situation by taking affirmative action.

So what are some helpful coping strategies? To find out, Medical News Today asked readers on social media to tell us what they do make their lives better at this uncertain time.

We also spoke to contributors from all over the world about their top coping tips.

In this Special Feature, we give you an overview of some top coping strategies. We also look at why scientists agree these actions can help improve our well-being.

Many people told MNT that exercising indoors or outdoors, as well as practicing yoga, meditation, or forms of prayer have helped to keep them grounded and focused.

One reader told us that, for them, walking and running [are] [g]reat stress reducers after long days at work, while another mentioned yoga, books, and praying as their go-to in these uncertain times.

Diana, from France, told MNT that it is thanks to regular exercise that she now feels less anxious and more optimistic. I have been exercising every morning with my neighbor, so for the past few days or past week, I have been feeling super positive, and everythings been O.K., she said.

We are permitted 3 hours for any activity, either alone or with one other person, Christina, from Greece, told us. I use this option to go out every day for a run. Therefore, physically and mentally, I feel very good.

It is not surprising that these activities have benefited the mental and physical well-being of people worldwide during the pandemic.

Numerous studies have demonstrated that physical activity, yoga, meditation, and prayer are all linked to better overall health.

Researchers have shown that exercise could prevent depression, boost aspects of our memory, reduce inflammation, and even increase lifespan.

Yoga and meditation could have a direct impact on physiological drivers of stress and resilience to hardship, while the simple presence of religious faith in someones life has ties to longevity.

In countries with less stringent public health emergency measures in place, many people have been taking advantage of the opportunity to take walks in nature.

One reader, reaching out to MNT on social media, said: I go for a walk every day, and I really appreciate nature [and] fresh air.

Researchers have linked walking, as a form of casual, non-strenuous exercise, to a variety of health benefits, including lower blood pressure, improved psychological well-being, and a longer lifespan.

Some of our readers have also said that they try to take advantage of nature and fresh air in any way they can. This might be by stepping outdoors for a while or just sitting out on the balcony.

Since the weather got warmer, [my family and I] have started going out on occasional walks in the forest near our house, Mihai, from Romania, told us.

During the day, [our young son] stays out on the balcony for a while, he tries to [entertain himself by spotting] cats, dogs, pigeons, he added.

One of the main lifelines for me has been reading in the garden in the sunshine, another MNT reader commented on social media.

Many readers have also told us that they have taken up gardening as a means to enjoy the fresh air and sunny weather, if they have access to a garden or a balcony.

While gardening can certainly be calming, it may bring many health benefits besides stress reduction. An older study published in The Medical Journal of Australia associated gardening with a 36% lower risk of developing dementia.

And a study published in the British Journal of Sports Medicine found that gardening also has associations with a lower risk of cardiovascular events such as stroke and heart attack.

But even just taking a moment to admire nature can do wonders for our well-being whether that be in the form of a potted plant, a fresh crop of cilantro grown on the window sill, or observing newly hatched baby ducks at the park.

A research paper published in the Journal of Positive Psychology in 2017 found that simply stopping to notice a bird or a tree has associations with a heightened sense of overall happiness.

Perhaps one of the most challenging aspects of the current pandemic has been of the physical distancing measures adopted by many countries.

Readers from all over the world have told MNT that they are worried about family members and friends whom they cannot see in person. They mention how they miss being able to meet up and engage in fun activities with those they love.

Yet many of them have expressed a strong determination in maintaining that human connection despite all the obstacles.

Almost all of the people reaching out to MNT have said that they have regular phone calls or video calls with friends and family. Some have found ways of replicating the interactions they would typically have with their loved ones over the internet.

Martina, who lives in Belgium, told us that she has been grateful for all the creative get-togethers that the people in her life have been planning:

To cope, I take advantage of the many initiatives organized by friends and family to keep us together. I do yoga online with a friend who is a teacher every day. [] I see my boss and my colleagues every Tuesday for a virtual coffee that [replaces] the ritual of our usual Tuesday lunch together. I have lunch with my family on Zoom almost every Sunday.

Some of the people we spoke to also noted that their employers have been taking steps to maintain their employees team spirit, and an atmosphere of collegiality.

For example, Mihai, in Romania, said that his company has been organizing 2-weekly meetings of 30 minutes each, in which we discuss anything aside from work.

[That is] to reduce our sense of isolation, he explained.

Studies suggest that long, deep conversations help us feel more connected and can enhance peoples sense of well-being. Social interaction may also help protect memory, according to some researchers.

Some experts have also linked lasting friendships and a good social life with better overall health and longevity.

Given all this, it is no wonder that frequent calls with friends, family, and colleagues provide a tangible sense of relief.

Readers who happen to be living with partners, family, or housemates, have also reported that playing board games helps them cope. Others play board games or computer games online with friends.

That, for instance, is the case of Ramona and Simona, who live in Sweden, and Stephen, in Canada, who told us that: Socially, weve been doing video calls and playing online board games and video games with friends and family. We even took part in a Zoom pub quiz.

Researchers have shown that playing and playfulness can help reduce stress levels in adults and increase their overall sense of well-being.

Some people have even linked board games to better brain function, and some studies have suggested that romantic partners who play together stay together, as the excitement and fun of board games help strengthen their bond.

Another favorite coping strategy from respondents all over the world is learning a new skill.

I also spend a lot of time teaching myself web coding through a free online course, taking and editing photos, and brushing up on my French with Duolingo, Stephen also told us, and other readers have sent us similar comments.

Research suggests that learning activities in adulthood may help improve life satisfaction and that learning new languages could help rejuvenate the brain.

All of these activities suggest that growth and adaptability have been key in facing the often life-altering circumstances that the COVID-19 pandemic has brought to everyone.

By scheduling frequent video calls with friends and sticking to a regular exercise routine, people have been doing their best to recreate their usual lifestyle at a different scale while relegated to their home environment.

Some, indeed, have gone to some lengths to do so. Misato, from Japan, told MNT that what she misses most is working from her favorite caf, a place that stimulates her focus and creativity. So she has recreated it at home.

[C]afs used to be one of my favorite places to refresh my thinking and mood but, by analyzing [] why cafs made me comfortable, I made [a] caf section in my room, which eventually reduces my stress, and I currently dont feel any stress not going to cafs.

Misato, Japan

Some researchers think the pandemic may kickstart a boom of creativity, not just in individual contexts but also in diverse economic fields.

While challenging in many ways, the current pandemic may end up proving that humans have what it takes to find a way out of any crisis. Perhaps all that we need, in the end, are some creative strategies.

For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.

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COVID-19: How the world is coping with restrictive measures - Medical News Today

These are my thought about the recent coronavirus pandemic.

Human beings have been dominating all other species on Earth. Now, the human is the only dictator, controlling other creatures, harvesting plants, feeding livestock, catching fish, consuming fossil fuels, producing various merchandise, polluting the air, contaminating oceans, extinguishing forests, melting icebergs, warming climates and exploding our population. All these elements have been accumulating. Human longevity has improved, so many people are concentrating in big cities and can transport over borders. Is this a real evolution? Is this the right direction for our future? Since this pandemic spread, it is really ironic that the environment has been gradually getting better. This is because we came to a point where we had to stop or slow down our basic, productive and social activities to prevent the virus from spreading. I suppose these circumstances seem comfortable and convenient for other species. Mother Earth would be blessed with the absence of humans. What I mean here is the present crisis is supposed to be a kind of punishment from God to conceited humans. Humans got too arrogant, did too much. We should recognize what we have damaged, sacrificed. The pursuit of our comfort and material wealth may not be the only way to sustain our society. We should stop now and think about better and more different ways to coexist with other creatures and Mother Earth.

Now is the moment when the warning bell is ringing loudly.

We have to listen to this sound carefully for assessing our past sins and reforming for the future.

However, like repeating history, we will perhaps again overcome this crisis with our shrewd intelligence and gigantic power without reflecting on ourselves. Furthermore, fortunately, or unfortunately, we are getting back to the previous normal and going in the same direction as ever.

I just hope we "don't miss the bell."

Aizumisato, Fukushima Prefecture

The opinions expressed in this letter to the editor are the writers own and do not necessarily reflect the policies of The Japan Times.

Originally posted here:
Time to heed the warning bell - The Japan Times

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, Steroid Replacement Therapy, Stem Cell Transplant By the end users,

Global Adrenomyeloneuropathy Treatment Market Segment By Application:

Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost 100 countries around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Adrenomyeloneuropathy Treatment market in 2020. COVID-19 can affect the global economy in three main ways: by directly affecting production and demand, by creating supply chain and market disruption, and by its financial impact on firms and financial markets. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future. This report also analyses the impact of Coronavirus COVID-19 on the Adrenomyeloneuropathy Treatment industry. Based on our recent survey, we have several different scenarios about the Adrenomyeloneuropathy Treatment YoY growth rate for 2020. The probable scenario is expected to grow by a xx% in 2020 and the revenue will be xx in 2020 from US$ xx million in 2019. The market size of Adrenomyeloneuropathy Treatment will reach xx in 2026, with a CAGR of xx% from 2020 to 2026. Global Adrenomyeloneuropathy Treatment market: Drivers and Restraints This section covers the various factors driving the global Adrenomyeloneuropathy Treatment market. To understand the growth of the market it is important to analyze the various drivers present the market. It provides data by value and volume of different regions and their respective manufacturers. This data will elaborate on the market share occupied by them, predict their revenue concerning strategies, and how they will grow in the future. After explaining the drivers, the report further evaluates the new opportunities and current trends in the market. Market restraints are factors hampering market growth. Studying these factors is equally pivotal as they help a reader need understand the weaknesses of the market. Global Adrenomyeloneuropathy Treatment market: Segment Analysis The global Adrenomyeloneuropathy Treatment market is split into two segments, type, and application. The product type briefs on the various types of products available in the market. The report also provides data for each product type by revenue for the forecast time period. It covers the price of each type of product. The other segment on the report, application, explains the various uses of the product and end-users. In the report, the researchers have also provided revenue according to the consumption of the product. Global Adrenomyeloneuropathy Treatment market: Regional Analysis The major regions covered in the report are North America, Europe, China, Rest of Asia Pacific, Central & South America, Middle East & Africa, etc. It includes revenue analysis of each region for the year 2015 to 2026. Global Adrenomyeloneuropathy Treatment market: Key Players The report lists the major players in the regions and their respective market share on the basis of global revenue. It also explains their strategic moves in the past few years, investments in product innovation, and changes in leadership to stay ahead in the competition. This will give the reader an edge over others as a well-informed decision can be made looking at the holistic picture of the market. By the therapy, the market is primarily split into, Steroid Replacement Therapy, Stem Cell Transplant By the end users, Hospitals, Clinics, Ambulatory Surgical Centers, Others

Competitive Landscape

It is important for every market participant to be familiar with the competitive scenario in the global Adrenomyeloneuropathy Treatment industry. In order to fulfil the requirements, the industry analysts have evaluated the strategic activities of the competitors to help the key players strengthen their foothold in the market and increase their competitiveness.

Key companies operating in the global Adrenomyeloneuropathy Treatment market include: :, Ascend Biopharmaceuticals, Novadip Biosciences, Eureka Therapeutics, Human Longevity, Regeneus, Allogene Therapeutics, BioRestorative Therapies, Immatics Biotechnologies, NewLink Genetics, Cytori Therapeutics, Talaris Therapeutics

Key questions answered in the report:

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TOC

1 Market Overview of Adrenomyeloneuropathy Treatment1.1 Adrenomyeloneuropathy Treatment Market Overview1.1.1 Adrenomyeloneuropathy Treatment Product Scope1.1.2 Market Status and Outlook1.2 Global Adrenomyeloneuropathy Treatment Market Size Overview by Region 2015 VS 2020 VS 20261.3 Global Adrenomyeloneuropathy Treatment Market Size by Region (2015-2026)1.4 Global Adrenomyeloneuropathy Treatment Historic Market Size by Region (2015-2020)1.5 Global Adrenomyeloneuropathy Treatment Market Size Forecast by Region (2021-2026)1.6 Key Regions Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.6.1 North America Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.6.2 Europe Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.6.3 China Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.6.4 Rest of Asia Pacific Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.6.5 Latin America Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.6.6 Middle East & Africa Adrenomyeloneuropathy Treatment Market Size YoY Growth (2015-2026)1.7 Coronavirus Disease 2019 (Covid-19): Adrenomyeloneuropathy Treatment Industry Impact1.7.1 How the Covid-19 is Affecting the Adrenomyeloneuropathy Treatment Industry

1.7.1.1 Adrenomyeloneuropathy Treatment Business Impact Assessment Covid-19

1.7.1.2 Supply Chain Challenges

1.7.1.3 COVID-19s Impact On Crude Oil and Refined Products1.7.2 Market Trends and Adrenomyeloneuropathy Treatment Potential Opportunities in the COVID-19 Landscape1.7.3 Measures / Proposal against Covid-19

1.7.3.1 Government Measures to Combat Covid-19 Impact

1.7.3.2 Proposal for Adrenomyeloneuropathy Treatment Players to Combat Covid-19 Impact 2 Adrenomyeloneuropathy Treatment Market Overview by Therapy2.1 Global Adrenomyeloneuropathy Treatment Market Size by Therapy: 2015 VS 2020 VS 20262.2 Global Adrenomyeloneuropathy Treatment Historic Market Size by Therapy (2015-2020)2.3 Global Adrenomyeloneuropathy Treatment Forecasted Market Size by Therapy (2021-2026)2.4 Steroid Replacement Therapy2.5 Stem Cell Transplant 3 Adrenomyeloneuropathy Treatment Market Overview by Therapy3.1 Global Adrenomyeloneuropathy Treatment Market Size by End Users: 2015 VS 2020 VS 20263.2 Global Adrenomyeloneuropathy Treatment Historic Market Size by End Users (2015-2020)3.3 Global Adrenomyeloneuropathy Treatment Forecasted Market Size by End Users (2021-2026)3.4 Hospitals3.5 Clinics3.6 Ambulatory Surgical Centers3.7 Others 4 Global Adrenomyeloneuropathy Treatment Competition Analysis by Players4.1 Global Adrenomyeloneuropathy Treatment Market Size (Million US$) by Players (2015-2020)4.2 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Adrenomyeloneuropathy Treatment as of 2019)4.3 Date of Key Manufacturers Enter into Adrenomyeloneuropathy Treatment Market4.4 Global Top Players Adrenomyeloneuropathy Treatment Headquarters and Area Served4.5 Key Players Adrenomyeloneuropathy Treatment Product Solution and Service4.6 Competitive Status4.6.1 Adrenomyeloneuropathy Treatment Market Concentration Rate4.6.2 Mergers & Acquisitions, Expansion Plans 5 Company (Top Players) Profiles and Key Data5.1 Ascend Biopharmaceuticals5.1.1 Ascend Biopharmaceuticals Profile5.1.2 Ascend Biopharmaceuticals Main Business and Companys Total Revenue5.1.3 Ascend Biopharmaceuticals Products, Services and Solutions5.1.4 Ascend Biopharmaceuticals Revenue (US$ Million) (2015-2020)5.1.5 Ascend Biopharmaceuticals Recent Developments5.2 Novadip Biosciences5.2.1 Novadip Biosciences Profile5.2.2 Novadip Biosciences Main Business and Companys Total Revenue5.2.3 Novadip Biosciences Products, Services and Solutions5.2.4 Novadip Biosciences Revenue (US$ Million) (2015-2020)5.2.5 Novadip Biosciences Recent Developments5.3 Eureka Therapeutics5.5.1 Eureka Therapeutics Profile5.3.2 Eureka Therapeutics Main Business and Companys Total Revenue5.3.3 Eureka Therapeutics Products, Services and Solutions5.3.4 Eureka Therapeutics Revenue (US$ Million) (2015-2020)5.3.5 Human Longevity Recent Developments5.4 Human Longevity5.4.1 Human Longevity Profile5.4.2 Human Longevity Main Business and Companys Total Revenue5.4.3 Human Longevity Products, Services and Solutions5.4.4 Human Longevity Revenue (US$ Million) (2015-2020)5.4.5 Human Longevity Recent Developments5.5 Regeneus5.5.1 Regeneus Profile5.5.2 Regeneus Main Business and Companys Total Revenue5.5.3 Regeneus Products, Services and Solutions5.5.4 Regeneus Revenue (US$ Million) (2015-2020)5.5.5 Regeneus Recent Developments5.6 Allogene Therapeutics5.6.1 Allogene Therapeutics Profile5.6.2 Allogene Therapeutics Main Business and Companys Total Revenue5.6.3 Allogene Therapeutics Products, Services and Solutions5.6.4 Allogene Therapeutics Revenue (US$ Million) (2015-2020)5.6.5 Allogene Therapeutics Recent Developments5.7 BioRestorative Therapies5.7.1 BioRestorative Therapies Profile5.7.2 BioRestorative Therapies Main Business and Companys Total Revenue5.7.3 BioRestorative Therapies Products, Services and Solutions5.7.4 BioRestorative Therapies Revenue (US$ Million) (2015-2020)5.7.5 BioRestorative Therapies Recent Developments5.8 Immatics Biotechnologies5.8.1 Immatics Biotechnologies Profile5.8.2 Immatics Biotechnologies Main Business and Companys Total Revenue5.8.3 Immatics Biotechnologies Products, Services and Solutions5.8.4 Immatics Biotechnologies Revenue (US$ Million) (2015-2020)5.8.5 Immatics Biotechnologies Recent Developments5.9 NewLink Genetics5.9.1 NewLink Genetics Profile5.9.2 NewLink Genetics Main Business and Companys Total Revenue5.9.3 NewLink Genetics Products, Services and Solutions5.9.4 NewLink Genetics Revenue (US$ Million) (2015-2020)5.9.5 NewLink Genetics Recent Developments5.10 Cytori Therapeutics5.10.1 Cytori Therapeutics Profile5.10.2 Cytori Therapeutics Main Business and Companys Total Revenue5.10.3 Cytori Therapeutics Products, Services and Solutions5.10.4 Cytori Therapeutics Revenue (US$ Million) (2015-2020)5.10.5 Cytori Therapeutics Recent Developments5.11 Talaris Therapeutics5.11.1 Talaris Therapeutics Profile5.11.2 Talaris Therapeutics Main Business and Companys Total Revenue5.11.3 Talaris Therapeutics Products, Services and Solutions5.11.4 Talaris Therapeutics Revenue (US$ Million) (2015-2020)5.11.5 Talaris Therapeutics Recent Developments 6 North America Adrenomyeloneuropathy Treatment by Players and by End Users6.1 North America Adrenomyeloneuropathy Treatment Market Size and Market Share by Players (2015-2020)6.2 North America Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 7 Europe Adrenomyeloneuropathy Treatment by Players and by End Users7.1 Europe Adrenomyeloneuropathy Treatment Market Size and Market Share by Players (2015-2020)7.2 Europe Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 8 China Adrenomyeloneuropathy Treatment by Players and by End Users8.1 China Adrenomyeloneuropathy Treatment Market Size and Market Share by Players (2015-2020)8.2 China Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 9 Rest of Asia Pacific Adrenomyeloneuropathy Treatment by Players and by End Users9.1 Rest of Asia Pacific Adrenomyeloneuropathy Treatment Market Size and Market Share by Players (2015-2020)9.2 Rest of Asia Pacific Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 10 Latin America Adrenomyeloneuropathy Treatment by Players and by End Users10.1 Latin America Adrenomyeloneuropathy Treatment Market Size and Market Share by Players (2015-2020)10.2 Latin America Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 11 Middle East & Africa Adrenomyeloneuropathy Treatment by Players and by End Users11.1 Middle East & Africa Adrenomyeloneuropathy Treatment Market Size and Market Share by Players (2015-2020)11.2 Middle East & Africa Adrenomyeloneuropathy Treatment Market Size by End Users (2015-2020) 12 Adrenomyeloneuropathy Treatment Market Dynamics12.1 Industry Trends12.2 Market Drivers12.3 Market Challenges12.4 Porters Five Forces Analysis 13 Research Finding /Conclusion 14 Methodology and Data Source 14.1 Methodology/Research Approach14.1.1 Research Programs/Design14.1.2 Market Size Estimation14.1.3 Market Breakdown and Data Triangulation14.2 Data Source14.2.1 Secondary Sources14.2.2 Primary Sources14.3 Disclaimer14.4 Author List

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Adrenomyeloneuropathy Treatment Market Size, Key Trends, Challenges and Standardization, Research, Key Players, Economic Impact and Forecast to 2026|...

Global Precision Medicine Software Market: Trends Estimates High Demand by 2027

The Precision Medicine Software Market 2020 report includes the market strategy, market orientation, expert opinion and knowledgeable information. The Precision Medicine Software Industry Report is an in-depth study analyzing the current state of the Precision Medicine Software Market. It provides a brief overview of the market focusing on definitions, classifications, product specifications, manufacturing processes, cost structures, market segmentation, end-use applications and industry chain analysis. The study on Precision Medicine Software Market provides analysis of market covering the industry trends, recent developments in the market and competitive landscape.

It takes into account the CAGR, value, volume, revenue, production, consumption, sales, manufacturing cost, prices, and other key factors related to the global Precision Medicine Software market. All findings and data on the global Precision Medicine Software market provided in the report are calculated, gathered, and verified using advanced and reliable primary and secondary research sources. The regional analysis offered in the report will help you to identify key opportunities of the global Precision Medicine Software market available in different regions and countries.

The final report will add the analysis of the Impact of Covid-19 in this report Precision Medicine Software industry.

Some of the companies competing in the Precision Medicine Software markets are: Syapse, Allscripts, Qiagen, Roper Technologies, Fabric Genomics, Foundation Medicine, Sophia Genetics, PierianDx, Human Longevity, Translational Software, Gene42, Inc, Lifeomic Health

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The report scrutinizes different business approaches and frameworks that pave the way for success in businesses. The report used Porters five techniques for analyzing the Precision Medicine Software Market; it also offers the examination of the global market. To make the report more potent and easy to understand, it consists of info graphics and diagrams. Furthermore, it has different policies and development plans which are presented in summary. It analyzes the technical barriers, other issues, and cost-effectiveness affecting the market.

Global Precision Medicine Software Market Research Report 2020 carries in-depth case studies on the various countries which are involved in the Precision Medicine Software market. The report is segmented according to usage wherever applicable and the report offers all this information for all major countries and associations. It offers an analysis of the technical barriers, other issues, and cost-effectiveness affecting the market. Important contents analyzed and discussed in the report include market size, operation situation, and current & future development trends of the market, market segments, business development, and consumption tendencies. Moreover, the report includes the list of major companies/competitors and their competition data that helps the user to determine their current position in the market and take corrective measures to maintain or increase their share holds.

What questions does the Precision Medicine Software market report answer pertaining to the regional reach of the industry

The report claims to split the regional scope of the Precision Medicine Software market into North America, Europe, Asia-Pacific, South America & Middle East and Africa. Which among these regions has been touted to amass the largest market share over the anticipated duration

How do the sales figures look at present How does the sales scenario look for the future

Considering the present scenario, how much revenue will each region attain by the end of the forecast period

How much is the market share that each of these regions has accumulated presently

How much is the growth rate that each topography will depict over the predicted timeline

A short overview of the Precision Medicine Software market scope:

Global market remuneration

Overall projected growth rate

Industry trends

Competitive scope

Product range

Application landscape

Supplier analysis

Marketing channel trends Now and later

Sales channel evaluation

Market Competition Trend

Market Concentration Rate

Reasons for Buying this Report

This report provides pin-point analysis for changing competitive dynamics

It provides a forward looking perspective on different factors driving or restraining market growth

It provides a six-year forecast assessed on the basis of how the market is predicted to grow

It helps in understanding the key product segments and their future

It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors

It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

Chapter 1:Precision Medicine Software Market Overview

Chapter 2: Global Economic Impact on Industry

Chapter 3:Precision Medicine Software Market Competition by Manufacturers

Chapter 4: Global Production, Revenue (Value) by Region

Chapter 5: Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6: Global Production, Revenue (Value), Price Trend by Type

Chapter 7: Global Market Analysis by Application

Chapter 8: Manufacturing Cost Analysis

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Precision Medicine Software Market Effect Factors Analysis

Chapter 12: GlobalPrecision Medicine Software Market Forecast to 2027

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Precision Medicine Software Market to See Massive Growth by 2026| Syapse, Allscripts, Qiagen, Roper Technologies, Fabric Genomics, Foundation...

Even after death, COVID-19 could be contagious, a new report finds.

A forensic practitioner working in Bangkok, Thailand, most likely caught the virus from a deceased patient, according to the report, which was posted online April 11 as a preprint for the Journal of Forensic and Legal Medicine.

The forensic practitioner later died of the virus, marking the first case on record of a "COVID-19 infection and death among medical personnel in a forensic medicine unit," the researchers wrote in the report.

Related: Latest COVID-19 news and US case counts

At the time the report was written on March 19, just 272 people in Thailand including the forensic practitioner and a nurse assistant had tested positive for the new coronavirus. Most of these cases were imported, meaning they weren't from community spread, the researchers wrote. So, it's unlikely that the forensic practitioner caught the new coronavirus outside of work or even from a patient at the hospital, the researchers wrote.

"There is [a] low chance of forensic medicine professionals coming into contact with infected patients, but they can have contact with biological samples and corpses," the researchers wrote in the report.

It's not surprising that the body of a recently deceased COVID-19 patient might be contagious, said Dr. Otto Yang, a professor in the Department of Medicine and the Department of Microbiology, Immunology and Molecular Genetics at the David Geffen School of Medicine at UCLA.

"Absolutely, a dead body would be contagious at least for hours if not days," Yang told Live Science in an email. "The virus will still be in respiratory secretions, and potentially still reproducing in cells that haven't yet died in the lungs."

COVID-19's longevity in the body can be problematic for people in the funerary industry. For instance, following reports that temples in Thailand were refusing to perform funeral services of COVID-19 victims, the head of Thailand's Department of Medical Services incorrectly announced on March 25 that the disease was not contagious in bodies after death, according to Buzzfeed News.

It's unclear, however, just how long the virus remains infectious in a dead body.

In light of this finding, forensic scientists should take a number of precautions while examining the remains of COVID-19 patients, the researchers said. For instance, forensic professionals should wear protective gear, including a protective suit, gloves, goggles, a cap and a mask, they wrote.

"The disinfection procedure used in operation rooms might be applied in pathology/forensic units too," they added.

Usually, pathogens that kill people don't survive long enough to spread to others after the person's death, according to the World Health Organization (WHO). "Human remains only pose a substantial risk to health in a few special cases, such as deaths from cholera or haemorrhagic fevers," such as Ebola, the WHO said.

Other illnesses that are contagious in human remains include tuberculosis, bloodborne viruses (such as hepatitis B and C and HIV) and gastrointestinal infections (including E. coli, hepatitis A, Salmonella infection and typhoid fever), according to the WHO.

Originally published on Live Science.

Continue reading here:
The bodies of COVID-19 victims may be contagious, coroner's case reveals - Livescience.com

The Arctic's ozone layer developed a tear, which grew into a hole, and then a bigger hole. Now, it may be biggest hole the North Pole's ozone layer has ever incurred.

This hole in the Arctic ozone layer reached an area of over 620,000 square miles since it was first spotted in February, said Diego Loyola, a scientist at the German Aerospace Center, in a statement to the European Space Agency.

Ozone levels in the area have dropped steeply since then.

That's unusual for a few reasons. While holes in the ozone layer are reported every year in the Antarctic, where temperatures are much colder, no sizable holes in the ozone layer have been recorded in the Arctic since 2011.

Even researchers with the Copernicus Program, the European Union's Earth observation program, who first caught the hole say they aren't sure why it's so large.

"The ozone has been, in this layer, almost completely depleted," said Vincent-Henri Peuch, director of the Copernicus Atmosphere Monitoring Service.

Life on Earth relies on the ozone layer, which sits in the stratosphere between 9 and 22 miles above the Earth, to protect us from ultraviolet radiation, which is known to cause skin cancer and suppress the immune system. But human-made chemicals have been poking holes in it for years -- there's been a hole in the Antarctic ozone layer every year since 1985, when the first one was reported by the British Antarctic Survey.

There are a few conditions necessary to tear a hole in the ozone layer. Among them are chlorofluorocarbons (CFCs), manufactured chemicals that have been phased out of consumer products after they were banned in 1996, and halons, formerly found in fire extinguishers, which accumulate in the atmosphere after they're emitted during human activity.

These chemicals can remain in the atmosphere between 50 and 100 years. Because of their longevity, the ozone layer isn't expected to fully heal until the end of the 21st century, according to the Environmental Protection Agency.

When the Antarctic is cloaked in below-freezing darkness, polar vortexes can form -- those are swirls of stratospheric clouds that facilitate the reactions between CFCs and the ozone layer (holes typically form when the weather is -108.4 degrees Fahrenheit).

When conditions are right, and the first sunlight after winter arrives, the ozone breaks the CFC bond to release a chlorine atom, which can poke a hole in the ozone layer, according to NASA Ozone Watch.

It's much rarer for ozone holes to form in the Arctic, where the mountainous terrain at high altitudes makes it difficult for polar vortexes to form and sustain their power, Peuch said.

But the existence of this record-breaking hole means that conditions must have been right in the Arctic. Peuch said it's still not clear why this hole formed, though.

The level of ozone fell steeply in the affected area throughout February and March, Peuch said.

As a result, the UV radiation that has made it to the Earth's surface is slightly higher than usual. But because the hole occurred in the winter into early spring, the UV index reached a high of 5, which is unusually high for this region but fairly normal for much of the United States, which hovers around an index of 5 or 6, according to the EPA's monthly UV averages.

This hole doesn't pose a huge deal for humans, though, Peuch said. Because the UV radiation is mostly affecting northern Greenland, which he said is sparsely populated, and the exposure won't last long, the effects of this ozone hole are minor.

One area that is of concern, he said, is how this could affect ecosystems in the area.

"That I cannot tell, but for human health, it's fairly moderate," he said.

And the hole isn't permanent, either: Peuch said he expects it to begin to close as soon as next week.

Link:
Scientists spotted what might be the biggest hole ever recorded in the Arctic's ozone layer - KDRV

While numerous studies have teased at potential benefits of resveratrol, a polyphenolic compound found in red wine and many plants, scientists are still trying to understand its impact on the human body. In a recent study out of University College London, author Dr. Henry Bayele has found an interesting explanation for its potential as an antiaging substance. Dr. Bayeles team found that resveratrol can mimic the hormone estrogen in the human body to activate antiaging proteins called sirtuins, which may help prevent age-related health problems.

The study, published in Scientific Reports, explores dietary sirtuin-activating compounds (dSTACs), including resveratrol. Sirtuins have become a promising target for researchers interested in slowing the aging process. They are proteins produced by the body that appear to impact metabolism and protect against several conditions including obesity, type 2 diabetes, cancer and cardiovascular and neurodegenerative diseases. Learning what spurs the body to produce sirtuins has been a common goal of longevity-focused scientists over the past two decades.

The interest in sirtuins started in 1999, when it was reported that the proteins activation can extend yeast lifespans by as much as 70 percent. The antiaging action of sirtuins appears to be conserved from yeast to mammals, stated a 2017 study published in Biogerontology. However, the complexity of their function increases with the complexity of the organism.

In the lab, Dr. Bayele and his team treated human liver cells in vitro with different types of compounds and found that resveratrol activated sirtuin signals through estrogen receptors by mimicking the hormone. Although estrogen is commonly defined as a female hormone, men and women both produce it, and it can help protect against the same things sirtuins prevent, such as heart disease.

Results also showed that resveratrol mimics estrogen in low doses, but becomes antiestrogenic in higher concentrations, consequently suppressing sirtuin signals. Excessive intake may in fact be counterproductive because, in high doses, the study found that resveratrol inhibited sirtuin activation of the estrogen receptors, Dr. Bayele told Wine Spectator. Therefore, the low doses of resveratrol found in a regular glass of red wine should be sufficient to activate the sirtuins. Simply put, for red wine or resveratrol to improve healthspan, less is more.

So whats a low dose? Dr. Bayele explains that a regular glass of table wine contains about 0.5 to 1 milligram of resveratrol. Of note, these concentrations are similar to those at which resveratrol behaves like estrogen to induce maximal sirtuin signaling through the estrogen receptors, he said.

Other dSTACs studied were better than resveratrol at activating sirtuins, such as isoliquiritigenin, which is found in licorice. According to Dr. Bayele, resveratrol has attracted the most attention due to its accessibility in red wine, combined with its demonstrable protection against metabolic, cardiovascular and neurodegenerative diseases. It has been shown to increase lifespan in diverse organisms, he writes in the study.

While the research shows promise, the findings have yet to face human trials or long-term studies, and must be better understood before potential treatments can be developed. Dr. Bayele also warns that dSTACs are poorly soluble, and its difficult to determine how much are absorbed in the cell culture. His main takeaway is that wine lovers must also incorporate a healthy diet to improve healthy aging and prevent the onset of metabolic and age-related diseases.

In the case of resveratrol, Dr. Bayele says that when humans consume it, only small amounts are rapidly absorbed, while a large proportion gets metabolized in the small intestine, which complicates the validity of the data. In short, it is still unclear how resveratrol intake would affect sirtuin signaling in vivo, but Dr. Bayele is confident that these dietary compounds are hidden treasures.

While [resveratrols] role in aging/lifespan regulation remains controversial, Dr. Bayele writes, Its contribution to healthspan is not in doubt.

Originally posted here:
How Might Resveratrol and Red Wine's Antiaging Properties Work? - Wine Spectator