Category Archives: Human Longevity

Watanabe, S., Kodama, S. & Hanabusa, H. Longevity and elderly care: Lessons from Japan. Glob. Health J. 2(4), 510 (2018).

Article Google Scholar

Rudnicka, E. et al. The World Health Organization (WHO) approach to healthy ageing. Maturitas 139, 611 (2020).

Article Google Scholar

Czekierda, K., Banik, A., Park, C. L. & Luszczynska, A. Meaning in life and physical health: Systematic review and meta-analysis. Health Psychol. Rev. 11, 387418. https://doi.org/10.1080/17437199.2017.1327325 (2017).

Article PubMed Google Scholar

Sherman, A. C. & Simonton, S. Effects of personal meaning among patients in primary and specialized care: Associations with psychosocial and physical outcomes. Psychol. Health 27, 475490. https://doi.org/10.1080/08870446.2011.592983 (2012).

Article PubMed Google Scholar

Roepke, A. M., Jayawickreme, E. & Riffle, O. M. Meaning and health: A systematic review. Appl. Res. Qual. Life. 9, 10551079. https://doi.org/10.1007/s11482-013-9288-9 (2014).

Article Google Scholar

Kim, E. S., Hershner, S. D. & Strecher, V. J. Purpose in life and incidence of sleep disturbances. J. Behav. Med. 38, 590597. https://doi.org/10.1007/s10865-015-9635-4 (2015).

Article PubMed Google Scholar

Cohen, R., Bavishi, C. & Rozanski, A. Purpose in life and its relationship to all-cause mortality and cardiovascular events: A meta-analysis. Psychosom. Med. 78, 122133. https://doi.org/10.1097/PSY.0000000000000274 (2016).

Article PubMed Google Scholar

Tanno, K. et al. Associations of ikigai as a positive psychological factor with all-cause mortality and cause-specific mortality among middle-aged and elderly Japanese people: Findings from the Japan Collaborative Cohort Study. J. Psychosom. Res. 67, 6775. https://doi.org/10.1016/j.jpsychores.2008.10.018 (2009).

Article PubMed Google Scholar

Steptoe, A., Deaton, A. & Stone, A. Subjective wellbeing, health, and ageing. Lancet 385(9968), 640648. https://doi.org/10.1016/S0140-6736(13)61489-0 (2015).

Article PubMed Google Scholar

McKnight, P. E. & Kashdan, T. B. Purpose in life as a system that creates and sustains health and well-being: An integrative, testable theory. Rev. Gener. Psychol. 13, 242251 (2009).

Article Google Scholar

Ryff, C. D. & Keyes, C. M. The structure of psychological well-being revisited. J. Personal. Soc. Psychol. 69, 719727 (1995).

CAS Article Google Scholar

Sone, T. et al. Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study. Psychosom Med. 70(6), 709715. https://doi.org/10.1097/PSY.0b013e31817e7e64 (2008).

Article PubMed Google Scholar

Nakanishi, N. Ikigai in older Japanese people. Age Ageing 28, 323324 (1999).

CAS Article Google Scholar

Kim, E. S. et al. Life satisfaction and subsequent physical, behavioral, and psychosocial health in older adults. Milbank Quart. 99(1), 209239 (2021).

Article Google Scholar

Feller, S., Teucher, B., Kaaks, R., Boeing, H. & Vigl, M. Life satisfaction and risk of chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. PLoS ONE 8(8), e73462. https://doi.org/10.1371/journal.pone.0073462 (2013).

ADS CAS Article PubMed PubMed Central Google Scholar

Rosella, L. C., Fu, L., Buajitti, E. & Goel, V. Death and chronic disease risk associated with poor life satisfaction: A population-based cohort study. Am. J. Epidemol. 188(2), 323331 (2019).

Article Google Scholar

Strine, T. W., Chapman, D. P., Balluz, L. S., Moriarty, D. G. & Mokdad, A. H. The associations between life satisfaction and health-related quality of life, chronic illness, and health behaviors among U.S. community-dwelling adults. J. Community Health 33, 4050 (2008).

Article Google Scholar

Grant, N., Wardle, J. & Steptoe, A. The relationship between life satisfaction and health behavior: A cross-cultural analysis of young adults. Int. J. Behav. Med. 16, 259268 (2009).

Article Google Scholar

Kim, E. S., Kubzansky, L. D. & Smith, J. Life satisfaction and use of preventive health care services. Health Psychol. 34(7), 779782. https://doi.org/10.1037/hea0000174 (2015).

Article PubMed Google Scholar

opuszaska, M., Szklarska, A., Lipowicz, A., Jankowska, E. A. & Kozie, S. Life satisfaction and cardiovascular disease in Poland. Arc. Med. Sci. 9(4), 629634 (2013).

Article Google Scholar

Liu, G., Xue, Y., Liu, Y., Wang, S. & Geng, Q. Multimorbidity in cardiovascular disease and association with life satisfaction: A Chinese national cross-sectional study. BMJ Open 10, e042950. https://doi.org/10.1136/bmjopen-2020-042950 (2020).

Article PubMed PubMed Central Google Scholar

National Institute of Health and Nutrition. Health Japan 21 (the second term) https://www.nibiohn.go.jp/eiken/kenkounippon21/en/kenkounippon21/index.html. Accessed 20 Aug 2021.

Ministry of Health, Labour and Welfare of Japan. The report on the interim evaluation of Health Japan 21 (2nd term). https://www.mhlw.go.jp/content/000378318.pdf. Accessed 20 Aug 2021.

US Department of Health and Human Services. National Action Plan to Improve Health Literacy (Office of disease prevention and health promotion, 2010).

Google Scholar

Chinese Ministry of Health. 66 tips of Health: Chinese Resident Health Literacy Manual (Peoples Medical Publishing House, 2018).

Google Scholar

Australian Commission on Safety and Quality in Health Care. National statement on health literacy. 2017. http://www.safetyandquality.gov.au/wp-content/uploads/2014/08/Health-Literacy-National-Statement.pdf. Accessed 20 Aug 2021.

Udagawa, K., Miyoshi, M. & Yoshiike, N. Mid-term evaluation of Health Japan 21: focus area for the nutrition and diet. Asia Pac. J. Clin. Nutr. 17, 445452 (2008).

PubMed Google Scholar

Tsuji, I. Current status and issues concerning Health Japan 21 (second term). Nutr. Rev. 78(S3), 1417 (2020).

Article Google Scholar

Public Relations Office, Government of Japan. What is Japan doing about metabolic syndrome? https://www.gov-online.go.jp/eng/publicity/book/hlj/html/201411/201411_02_en.html#:~:text=In%20a%20%E2%80%9CSmart%20Life%20Project,participating%20companies%20and%20through%20each. Accessed 20 Aug 2021.

Nutbeam, D. Health literacy as a public health goal: A challenge for contemporary health education and communication strategies into the 21st century. Health Promot. Int. 15, 259267 (2000).

Article Google Scholar

Nutbeam, D. Health literacy as a population strategy for health promotion. Jpn. J Health Edu. Prom. 25(3), 210222 (2017).

Google Scholar

Srensen, K. et al. Health literacy and public health: A systematic review and integration of definitions and models. BMC Public Health 12, 80 (2012).

Article Google Scholar

Musich, S., Wang, S. S., Kraemer, S., Hawkins, K. & Wicker, E. Purpose in life and positive health outcomes among older adults. Popul. Health Manag. 21(2), 139147. https://doi.org/10.1089/pop.2017.0063 (2018).

Article PubMed PubMed Central Google Scholar

Smith, S. G. et al. Low health literacy predicts decline in physical function among older adults: Findings from LitCog cohort study. J. Epidemol. Com Health. 69(5), 474480 (2015).

Article Google Scholar

Van der Heide, I. et al. The relationship between health education, and health literacy: Results from Dutch Adult Literacy and Life Skills Survey. J. Health Commun. 18(S1), 172184 (2013).

Article Google Scholar

Al Sayah, F., Majumdar, S. R., Williams, B., Robertson, S. & Johnson, J. A. Health literacy and health outcomes in diabetes: A systematic review. J. Gen. Intern. Med. 28(3), 444452 (2013).

Article Google Scholar

Magnani, J. W. et al. Health literacy and cardiovascular disease: Fundamental relevance to primary and secondary prevention. Circulation 138, e48e74. https://doi.org/10.1161/cir.0000000000000579 (2018).

Article PubMed PubMed Central Google Scholar

Visscher, B. B. et al. Evidence on the effectiveness of health literacy interventions in the EU: A systematic review. BMC Public Health 18, 1414. https://doi.org/10.1186/s12889-018-6331-7 (2018).

Article PubMed PubMed Central Google Scholar

Muller, I. et al. Effects on engagement and health literacy outcomes of web-based materials promoting physical activity in people with diabetes: An international randomized trial. J. Med. Internet Res. 19(1), e21 (2017).

Article Google Scholar

Trezona, A., Dodson, S., Mech, P. & Osborne, R. H. Development and testing of a framework for analysing health literacy in public policy documents. Glob. Health Promot. 25(4), 2433. https://doi.org/10.1177/1757975918769616 (2018).

Article PubMed Google Scholar

Weishaar, H., Hurrelmann, K., Okan, O., Horn, A. & Schaeffer, D. Framing health literacy: A comparative analysis of national action plans. Health Policy 123(1), 1120 (2019).

Article Google Scholar

Japanese Association of Preventive Medicine for Adult Disease. Kenko kanrisi (Specialists of health management). https://www.healthcare.or.jp. Accessed 20 Aug 2021.

Ishikawa, H., Nomura, K., Sato, M. & Yano, E. Developing a measure of communicative and critical health literacy: A pilot study of Japanese office workers. Health Promot. Int. 23(3), 269274 (2008).

Article Google Scholar

Imai, T., Osada, H. & Nishimura, Y. The reliability and validity of a new scale for measuring the concept of Ikigai (Ikigai-9). Jpn. J. Public Health 59, 433440 (2012) (In Japanese).

Google Scholar

Wood, A. M. & Joseph, S. The absence of positive psychological (eudemonic) well-being as a risk factor for depression: A ten year cohort study. J. Affect. Disord. 122(3), 213217. https://doi.org/10.1016/j.jad.2009.06.032 (2010).

Article PubMed Google Scholar

Alimujiang, A. et al. Association between life purpose and mortality among US adults older than 50 years. JAMA Net Open 2, e194270 (2019).

Article Google Scholar

Krause, N. Meaning in life and mortality. J. Gerontol. Ser. B Psychol. Sci. Social Sci. 64B(4), 517527. https://doi.org/10.1093/geronb/gbp047 (2009).

Article Google Scholar

Koizumi, M., Ito, H., Kaneko, Y. & Motohashi, Y. Effect of having a sense of purpose in life on the risk of death from cardiovascular diseases. J. Epidemol. 18(5), 191196. https://doi.org/10.2188/jea.je2007388 (2008).

Article Google Scholar

Boehm, J. K., Peterson, C., Kivimaki, M. & Kubzansky, L. D. Heart health when life is satisfying: Evidence from the Whitehall II cohort study. Eur. Heart J. 32, 26722677. https://doi.org/10.1093/eurheartj/ehr203 (2011).

Article PubMed PubMed Central Google Scholar

Diener, E. & Chan, M. Y. Happy people live longer: Subjective well-being contributes to health and longevity. Appl. Psychol. Health Well-Being 3, 143 (2011).

Article Google Scholar

Grant, N., Wardle, J. & Steptoe, A. The relationship between life satisfaction and health behavior: A cross-cultural analysis of young adults. Int. J. Behav. Med. 16, 259268. https://doi.org/10.1007/s12529-009-9032-x (2009).

Article PubMed Google Scholar

Lee, H. & Singh, G. K. Association of happiness and life satisfaction with cancer mortality in the United States: A longitudinal analysis. Int. J. Transl. Med. Res. Public Health 4(2), 162169. https://doi.org/10.21106/ijtmrph.206 (2020).

Article Google Scholar

Feller, S., Teucher, B., Kaaks, R., Boeing, H. & Vigl, M. Life satisfaction and risk of chronic diseases in the European prospective investigation into cancer and nutrition (EPIC)-Germany study. PLoS ONE 8, e73462. https://doi.org/10.1371/journal.pone.0073462 (2013).

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Resplendent with beady eyes, snapping pincers and shiny bodies, little creatures scurry in neat lines toward a delicious morsel of food. These little creatures, otherwise known as ants (Formicidae), are both wondrous in behavior and considered pests by many.

According to researchers at the Universite Sorbonne Paris Nord, Universite Paris-Saclay, and other French research institutions, these tiny critters can be trained to sniff out the specific odors associated with certain cancers. Published in the journal iScience, scientists found that after training, ants could learn to discriminate between cancerous cell cultures and non-cancerous cell cultures.

For Patrizia dEttorre, Ph.D., a Professor in Ethology and one of the senior authors of the study, ants have long provided a fascinating topic for study. Their societies are very complex and have very amazing strategies of communication, she told BioSpace. In particular, they rely on chemical communication.

According to dEttorre, ants can use pheromones, or secreted/excreted chemicals, to identify each other. Because ants have well-developed olfactory (smelling) systems, they can distinguish specific smells and associate those smells with specific behaviors. Previous work has demonstrated that ant-produced pheromones can act to signal danger or create chemical trails to lead other ants toward food sources.

A Ph.D. student of dEttorres Ph.D. was inspired by the role of chemical signals in ant behavior - and wondered if this signaling could be leveraged to identify specific cancers. Some cancerous cells produce volatile organic compounds (VOCs) through metabolism. VOCs, which can be released into the bloodstream, excreted through bodily fluids or exhaled into the air, represent a cancer fingerprint that can sometimes act as a biomarker for the presence of cancer.

The scientists hypothesized that ants, with their evolutionarily optimized olfactory senses, could potentially be trained to detect these cancer VOCs. After creating a collaboration with a research group that cultured cancer cell lines, the scientists proceeded to train the ants (specifically in their case, F. Fusca) in the art of cancer detection.

Training the ants and quantifying whether or not the training worked was simple to look at. You teach the ant to associate the odor of a [for example] flower, or in this case, a cancer cell, dEttorre explained. You teach the ant to associate this odor with a reward; in our case, a sugar solution.

After positively reinforcing the odor with a reward two or three times, the scientists placed the ants in a test arena - a petri dish containing a cell line associated with the reward and a control cell line not associated with anything.

You test the ant with the odor that she knows, and another odor - something that is totally new, like a different cancer cell medium or another flower, dEttorre said. Then, you just look at what the ant does. And of course, the ant suspects that there is sugar close to the odor that she had learned.

To quantify how well the training worked and if the ants were able to distinguish the cancer cell line from a normal cell line, the scientists recorded their behavior using a video camera and timed how long the ants spent around each cell line.

They first found that the ants could learn to identify odors (VOCs) associated with a cancer cell line, given a sugar solution reward. Over an increased number of trials, the ants spent progressively less time trying to find the reward - indicating that they had learned what the specific cancer odor was and linked that odor to the reward.

After testing ants on discrimination between a breast-cancer-derived epithelium cancer cell line and a healthy breast cell line, the scientists found that the ants spent significantly more time near the cancer cell line (that they had previously been trained to associate with the reward). Additionally, the ants were adept at discriminating between two different cancer cell lines, given that one cancer cell line was associated with the reward and the other was not.

The training method used to guide ants towards associating cancer cell lines with a sugary reward is called classical conditioning - and according to dEttorre, using positive reinforcement in this way was optimal for training them.

Its much nicer to be nice to them, she said with a smile. Aversive conditioning normally takes more time and not all the ants will learn it well. This (classical conditioning) is easy and it works well.

dEttorre noted that the longevity of this training is limited by the need for or presence of a specific resource. She explained that if a certain smell is no longer predictive of the reward, then there would be little point for the creature to continue going towards that smell. Therefore, the optimal path would be training the ants to identify the cancer based on classical conditioning, and then immediately testing them.

We could test them several times, but the point is not to do that, she said. To be reliable, its good to test it like we did, only two or three times.

In the future, dEttorre and the team hopes to train ants to detect organisms with cancer, rather than just cancerous cell lines. The volatile organic compounds that you get [in cell lines] are not as complex as they would be when they are in an organism, she explained. The next step is to test the odor of mice that have a cancer, or not.

Even so, the premise of having ants scurrying toward cancer is intriguing as a clinical strategy for human cancer diagnoses. For dEttorre, the goal would be to use these ants as a tool for early diagnosis - essentially flagging a sample for downstream analysis.

It will be like an alert, she said. The sooner we have the cancer detected, the more likely the person will survive.

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Researchers Prove Potential of Training Ants to Sniff Out Cancer - BioSpace

Professor Valter Longo

Examining a range of nutrition research from studies in laboratory animals to epidemiological research in human populations provides a clearer picture of the best diet for a longer, healthier life, said USC Leonard Davis School of Gerontology professor Valter Longo.

In an article that includes a literature review published April 28 in Cell, Longo and coauthor Rozalyn Anderson of the University of Wisconsin describe the longevity diet, a multi-pillar approach based on studies of various aspects of diet, from food composition and calorie intake to the length and frequency of fasting periods.

We explored the link between nutrients, fasting, genes and longevity in short-lived species, and connected these links to clinical and epidemiological studies in primates and humans including centenarians, Longo said. By adopting an approach based on over a century of research, we can begin to define a longevity diet that represents a solid foundation for nutritional recommendations and for future research.

Longo and Anderson reviewed hundreds of studies on nutrition, diseases and longevity in laboratory animals and humans and combined them with their own studies on nutrients and aging. The analysis included popular diets such as the restriction of total calories, the high-fat and low-carbohydrate ketogenic diet, vegetarian and vegan diets, and the Mediterranean diet.

The article also included a review of different forms of fasting, including a short-term diet that mimics the bodys fasting response, intermittent fasting (frequent and short-term) and periodic fasting (two or more days of fasting or fasting-mimicking diets more than twice a month). In addition to examining lifespan data from epidemiological studies, the team linked these studies to specific dietary factors affecting several longevity-regulating genetic pathways shared by animals and humans that also affect markers for disease risk. These include levels of insulin, C-reactive protein, insulin-like growth factor 1, and cholesterol.

The authors report that the key characteristics of the optimal diet appear to be moderate to high carbohydrate intake from non-refined sources, low but sufficient protein from largely plant-based sources, and enough plant-based fats to provide about 30 percent of energy needs. Ideally, the days meals would all occur within a window of 11-12 hours, allowing for a daily period of fasting. Additionally, a 5-day cycle of a fasting or fasting-mimicking diet every 3-4 months may also help reduce insulin resistance, blood pressure and other risk factors for individuals with increased disease risks.

Longo described what a longevity diet could look like in real life: Lots of legumes, whole grains, and vegetables; some fish; no red meat or processed meat and very low white meat; low sugar and refined grains; good levels of nuts and olive oil, and some dark chocolate.

The next step in researching the longevity diet will be a 500-person study taking place in southern Italy, Longo said. The longevity diet bears both similarities and differences to the Mediterranean-style diets often seen in super-aging Blue Zones, including Sardinia, Italy; Okinawa, Japan; and Loma Linda, California. Common diets in these communities known for a high number of people age 100 or older are often largely plant-based or pescatarian and are relatively low in protein. But the longevity diet represents an evolution of these centenarian diets, Longo explained, citing the recommendation for limiting food consumption to 12 hours per day and having several short fasting periods every year.

In addition to the general characteristics, the longevity diet should be adapted to individuals based on sex, age, health status, and genetics, Longo noted. For instance, people over age 65 may need to increase protein in order to counter frailty and loss of lean body mass. Longos own studies illustrated that higher protein amounts were better for people over 65 but not optimal for those under 65, he said.

For people who are looking to optimize their diet for longevity, he said its important to work with healthcare provider specialized in nutrition on personalizing a plan focusing on smaller changes that can be adopted for life, rather than big changes that will cause an harmful major loss of body fat and lean mass, followed by a regain of the fat lost, once the person abandons the very restrictive diet.

The longevity diet is not a dietary restriction intended to only cause weight loss but a lifestyle focused on slowing aging, which can complement standard healthcare and, taken as a preventative measure, will aid in avoiding morbidity and sustaining health into advanced age, Longo said.

The article, Nutrition, longevity and disease: from molecular mechanisms to interventions, was coauthored by Professor Rozalyn M. Anderson of the University of Wisconsin School of Medicine and Public Health. This work was supported in part by awards to Longo, including the Associazione Italiana per la Ricerca sul Cancro (IG#17605 and IG#21820.), the BC161452 grant of the Breast Cancer Research Program (US Department of Defense) and the National Institute on Aging-National Institutes of Health grants P01 AG055369. Anderson is supported by NIH-NIA RF1AG057408, R01AG067330, R01AG074503, Veterans Administration Merit Award BX003846, and by Impetus Grants and the Simons Foundation. This work was made possible by support from the William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.

Longo is the founder of and has an ownership interest in L-Nutra; the companys food products are used in studies of the fasting-mimicking diet. Longos interest in L-Nutra was disclosed and managed per USCs conflict-of-interest policies. USC has an ownership interest in L-Nutra and the potential to receive royalty payments from L-Nutra. USCs financial interest in the company has been disclosed and managed under USCs institutional conflict-of-interest policies.

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Study: Valter Longo Characterizes Longevity Diet | USC Gerontology

Coupled with a lack of sufficient prevention strategies and clinical interventions for age-related diseases, the enormous growth of the elderly population poses a significant socioeconomic and healthcare challenge worldwide. With life expectancy rising across the globe save for the short-term declines caused by the COVID-19 pandemic more patients are expected to suffer from disease and disability in later life and for more years than before.

As a result, the focus of medicine is expanding to include not just the treatment of acute or chronic illness but also the long-term maintenance of health. The development of modalities for reducing age-associated morbidities and disabilities has become a primary target for investment and innovation in the scientific field.

As our collective understanding of human life evolves, the concept of a healthspan, quantifiable by total years of life with disability or disease (YLD), is becoming more clinically prominent. Similarly, the idea of a lifespan, which can be evaluated using the mortality metric of premature years of life lost (PYLL), has attracted increasing attention as we witness breakthroughs in anti-aging medicine every day. Aiming to enhance the average healthspan while elongating the lifespan, the longevity industry offers a potentially fulfillable promise of semi-immortality and everyone wants in.

The Longevity Market: Current Overview

Anti-aging, longevity science, and life extension are all terms that encompass the emerging, evidence-backed approaches to delaying the onset of age-related health decline while prolonging the human lifespan by intervening in the aging process itself. As an industry, the anti-aging and longevity market has been steadily increasing in size over the past few decades and shows no signs of slowing down with significant investment activity in recent years.

Due in part to major advancements in scientific understanding and technologic capabilities, the industry focus has shifted to an exponential-type medicine, marked by continuous innovation and testing of the limits of the human lifespan. Genome sequencing, epigenetics, exosomes, RNA transcriptomics, and other established and emerging anti-aging therapies are only the tip of the iceberg.

Investing in Longevity Innovation

According to the latest reports, investments in anti-aging and life extension biotechnology are growing exponentially. Some of the largest financial institutions and corporations, along with the worlds wealthiest individuals, are financing this field. Thus, helping to make it one of the fastest-growing sectors in recent history, expected to reach a market size of $64.04 billion by 2026 a 45% increase from 2020.

Ultimately, aging is a diseasea disease that many of the most powerful people on the planet believe can be slowed, stopped, even reversed, Peter Diamandis, founder of XPRIZE Foundation, bestselling author, and key opinion leader in the space writes on his blog. Diamandis highlights the outsized potential for industry growth due to unmet and unmatched needs, which have attracted investors from major corporate entities, including Alphabet, AbbVie, and BlackRock, to private individuals, such as PayPal co-founder Peter Thiel.

This influx of financial capital is set to propel the industry forward for many years to come. According to information platform Crunchbase, 2021 was a record-setting year for new startup unicorns, namely data-driven drug developer Valo Health and AI-based drug developer Insilico Medicine.

That year also witnessed one of the largest funding rounds in the industry: a record-breaking $3 billion in capital for Altos Labs a biotechnology startup focused on cellular rejuvenation and age-related disease reversal from prominent investors, including Jeff Bezos.

As competition in the life extension space grows, the worlds leading entities are making their bids. For instance, technology conglomerate Alphabet is actively working on combating aging and age-related disease via their subsidiary biotechnology company Calico Life Sciences. At the same time, Lineage Cell Therapeutics, funded by BlackRock, Wells Fargo, and other major players, is in the process of developing novel cell therapies for currently unmet clinical needs. Meanwhile, CEO of cryptocurrency giant Coinbase Brian Armstrong recently announced the launch of his epigenetic reprogramming company NewLimit, with an initial investment of $150M and the goal of extending the human healthspan.

Industry Growth Factors

In addition to tremendous financial investment, there are several other factors positively influencing growth in the anti-aging and longevity industry. Firstly, there is a growing demand among the patient population to treat and prevent age-related diseases, which is rising alongside an increased elderly population.

Secondly, technological advancements are making research and development in the space more successful, efficient, and accessible. The ability to produce anti-aging and preventative therapeutics at lower costs with increased efficiency and reliability has the potential to make the quest for immortality more pragmatic.

Finally, the belief that the longevity market may outpace and potentially replace the existing health care market in the long term suggests that the shift within the system away from illness-based to wellness-based may be permanent. Consequently, the longevity ecosystem would present a unique opportunity for all stakeholders to collaborate and innovate at the forefront of aging-related therapeutics, services, and technology.

Challenges and Opportunities Ahead

This burgeoning industry is not without its challenges. While there are still many roadblocks facing this sector including regulatory uncertainty, lack of robust clinical evidence, and consumers misunderstanding the science, these barriers are not insurmountable.

As companies adjust their missions and adapt more long-term longevity strategies to replace the current healthcare model, the paradigm will shift in response. Experts in the field of longevity forecast 2022 and the upcoming few years to be pivotal for the market and the health- and lifespan of the population as a whole. At this point in time, the medical industry is on the precipice of a future few can envision based on a profoundly deepened scope of human life and its limitations.

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Investing in Immortality: The Multibillion-Dollar Longevity Science and Anti-Aging Industry - Anti Aging News

Eating only during your most active time of day, while following a reduced-calorie diet, may lead to a substantially longer life, according to new research conducted on mice.

One recipe for longevity is simple, if not easy to follow: eat less. Restricting calories can lead to a longer, healthier life, as studies have shown in a variety of animals.

Now, new research suggests that the bodys daily rhythms play a significant role in this longevity effect. Eating only during their most active time of day substantially extended the lifespan of mice on a reduced-calorie diet, Howard Hughes Medical Institute (HHMI) Investigator Joseph Takahashi and colleagues reported in the journal Science on May 5, 2022.

In his teams study of hundreds of mice over four years, a reduced-calorie diet alone extended the animals lives by 10 percent. But feeding mice the diet only at nighttime, when mice are most active, extended life by 35 percent. That combo a reduced-calorie diet plus a nighttime eating schedule tacked on an extra nine months to the animals typical two-year median lifespan. For people, an equivalent plan would limit eating to daytime hours.

Experiments that tested various diet plans in mice found that the animals live longest on a low-calorie diet with daily fasting periods. Credit: Fernando Augusto/http://made-for.studio

The research helps disentangle the controversy around diet plans that emphasize eating only at certain times of day, says Takahashi, a molecular biologist at the University of Texas Southwestern Medical Center. Such plans may not speed weight loss in humans, as a recent study in the New England Journal of Medicine reported, but they could prompt health benefits that add up to a longer lifespan.

Takahashis teams findings highlight the crucial role of metabolism in aging, says Sai Krupa Das, a nutrition scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging who was not involved with the work. This is a very promising and landmark study, she says.

Decades of research has found that calorie restriction extends the lifespan of animals ranging from worms and flies to mice, rats, and primates. Those experiments report weight loss, improved glucose regulation, lower blood pressure, and reduced inflammation.

But it has been difficult to systematically study calorie restriction in people, who cant live in a laboratory and eat measured food portions for their entire lives, Das says. She was part of the research team that conducted the first controlled study of calorie restriction in humans, called the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy, or CALERIE. In that study, even a modest reduction in calories was remarkably beneficial for reducing signs of aging, Das says.

HHMI Investigator Joseph Takahashis team has discovered that eating a calorie-restricted diet at the right time of day can extend lifespan in mice. Credit: Brandon Wade/AP Images for HHMI

Scientists are just beginning to understand how calorie restriction slows aging at the cellular and genetic level. As an animal ages, genes linked to inflammation tend to become more active, while genes that help regulate metabolism become less active. Takahashis new study found that calorie restriction, especially when timed to the mices active period at night, helped offset these genetic changes as mice aged.

Recent years have seen the rise of many popular diet plans that focus on whats known as intermittent fasting, such as fasting on alternate days or eating only during a period of six to eight hours per day. To unravel the effects of calories, fasting, and daily, or circadian, rhythms on longevity, Takahashis team undertook an extensive four-year experiment. The team housed hundreds of mice with automated feeders to control when and how much each mouse ate for its entire lifespan.

Some of the mice could eat as much as they wanted, while others had their calories restricted by 30 to 40 percent. And those on calorie-restricted diets ate on different schedules. Mice fed the low-calorie diet at night, over either a two-hour or 12-hour period, lived the longest, the team discovered.

The results suggest that time-restricted eating has positive effects on the body, even if it doesnt promote weight loss, as the New England Journal of Medicine study suggested. Takahashi points out that his study likewise found no differences in body weight among mice on different eating schedules however, we found profound differences in lifespan, he says.

Rafael de Cabo, a gerontology researcher at the National Institute on Aging in Baltimore says that the Science paper is a very elegant demonstration that even if you are restricting your calories but you are not [eating at the right times], you do not get the full benefits of caloric restriction.

Takahashi hopes that learning how calorie restriction affects the bodys internal clocks as we age will help scientists find new ways to extend the healthy lifespan of humans. That could come through calorie-restricted diets, or through drugs that mimic those diets effects.

In the meantime, Takahashi is taking a lesson from his mice he restricts his own eating to a 12-hour period. But, he says, if we find a drug that can boost your clock, we can then test that in the laboratory and see if that extends lifespan.

Reference: Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice by Victoria Acosta-Rodrguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green and Joseph S. Takahashi, 5 May 2022, Science.DOI: 10.1126/science.abk0297

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Fountain of Youth: Cutting Calories and Eating at the Right Time of Day Leads to a Longer Life - SciTechDaily

OSAKA, Japan Adopting healthier lifestyle habits can lead to a longer life even if youre already in your 80s, a new study reveals.

Researchers from Osaka University say reducing drinking, not smoking, losing weight, and getting more sleep leads to the biggest gains. These habits increased longevity by six years in healthy 40-year-olds, with benefits even more prominent in those twice that age.

Moreover, the benefits also applied to individuals with life-threatening illnesses including cancer, cardiovascular disease, high blood pressure, diabetes, and kidney disease. The study shows it is never too late to give up bad habits and shed extra pounds from middle age onwards. The findings come from a review of almost 50,000 people in Japan, tracked for up to 20 years.

This is a particularly important finding given that the prevalence of chronic disease has increased globally and is a major cause of death in older populations, says senior author Professor Hiroyasu Iso in a university release.

The Osaka University team say taking ownership of your health is key to a pleasurable retirement. They add that idioms and proverbs about how importance it is to maintain good health span all of history. Many of these emphasize the close relationship between health and happiness.

The analysis in the journal Age and Ageing found healthy behaviors have a marked effect on the human lifespan. Adopting five or more healthy habits increased life expectancy even for those over 80 years-old and those with chronic conditions.

Researchers add that lifespan is also dependent on socioeconomic status, policies such as assisted access to healthcare, and lifestyle factors. Between 1988 and 1990, study participants filled in surveys that included questions about diet and exercise, alcohol consumption, smoking status, sleep duration, and their BMI (body mass index). They also reported on any illnesses they dealt with over the years.

The aim of the study was to increase knowledge about what factors contribute to death from cancer and cardiovascular disease. The team awarded points for each healthy behavior and assessed the impact of modifying them on projected lifespan. The project continued until December 2009, by which time nearly 9,000 individuals had died.

The results were very clear. A higher number of modified healthy behaviors was directly associated with great longevity for both men and women, says first author Dr. Ryoto Sakaniwa.

It is one of the first studies to measure the impact of improvements to health behavior among older individuals in a country with a national life expectancy of almost 85 years.

The finding that lifestyle improvements has a positive impact on health despite chronic health conditions and older age is an empowering one, especially given the increasing prevalence of chronic conditions and longer life, the researchers write in a statement.

The findings of this study will contribute to the design of future healthcare settings, public health approaches, and policies that work in partnership with patients to promote healthy lifestyle choices.

South West News Service writer Mark Waghorn contributed to this report.

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Adopting these healthy habits can add years to your life -- even in your 80s - Study Finds

Head lice treatment is advised for those identified with an active infestation. All household members and any close connections should be tested, with those who exhibit symptoms of an active infestation being treated. Some specialists in states such as Philadelphia, PA, feel that preventive therapy is necessary for people who share a bed with actively infected people. Everyone who is infested, including their bedmates, should be treated simultaneously. Longevity Live Partner Content.

Some pediculicides (lice-killing drugs) have an ovicidal effect. Re-treatment is advised for pediculicides that are either mildly ovicidal or not ovicidal. Re-treatment is only advised for more highly ovicidal individuals if live lice are still present several days following treatment.

Before you begin treatment, figure out how your child acquired head lice. Head lice do not leap, do not survive on pets, and have no bearing on personal hygiene. Head-to-head contact is the most typical way for head lice to spread. This indicates that your youngster has contacted someone in states such asHouston, TX, who has head lice. This might happen in or out of school during sports, sleepover parties, or playtime.

Sharing personal objects that come into contact with the head, such as hats, hairbrushes, and hair accessories, is less likely to contract head lice.

Take actions to prevent head lice from spreading to other family members if your kid has been diagnosed with head lice.

Head lice may be controlled by washing hats, pillowcases, and other objects that come into contact with the head in hot water. However, it is not required to sanitize your whole home in states such asKansas City, MO, as head lice transmission from inanimate things is uncommon.

To effectively cure head lice, you must first comprehend your foe. Head lice can take one or more of the following forms.

All three generations of head lice must be nonviable or dead to get rid of head lice for good.

To live, head lice require a human host. Head lice are gone if the hair is gone. While cutting a childs hair may appear to be a drastic measure, it may be the best option for some parents. If your child already has short hair, eliminating their environment may be the best way to deal with head lice.

An over-the-counter head lice treatment, usually in shampoo, is your first line of defense against head lice. The critical differences between treatments are the active component and the stages of head lice it kills. Because most over-the-counter head lice treatments dont kill nits, a second application may be required to eliminate the nymphs after they hatch.

One of the reasons that over-the-counter head lice treatments in states such asRaleigh, NC, fail is that they are not utilized correctly. Parents may divide a single dosage into many applications, or depart from the recommendations in various ways. If you followed the instructions correctly, you should not notice any crawling head lice after the first treatment. However, if youre still seeing live crawlers, you could have skipped a step, or the treatment isnt working for the type of lice your child has.

One of the reasons that over-the-counter head lice treatments in states such asRaleigh, NC, fail is that they are not utilized correctly. Parents may divide a single dosage into many applications, or depart from the recommendations in various ways. If you followed the instructions correctly, you should not notice any crawling head lice after the first treatment. However, if youre still seeing live crawlers, you could have skipped a step, or the treatment isnt working for the type of lice your child has.

Some parents use tea tree oil, mayonnaise, neem oil, vinegar, saline spray, and other home treatments for head lice. Unfortunately, these therapies are inconvenient, time-consuming, and lack scientific backing. If an over-the-counter head lice treatment didnt work, and youre sure your child wasnt re-infested, seek expert help. One way to do this is to search for lice removal near me.This will give you plenty of experts to cater to your needs.

Its conceivable that the head lice are resistant to the active component in your lice treatment. Consult your doctor or a pediatric dermatologist in states likePhiladelphia, PA, for a prescription head lice treatment.

Hot-air approaches are highly successful in destroying nits, but less so in eradicating live lice research. To maximize your chances of removing the tiny buggers, use a hair dryer on freshly washed hair. After administering a chemical lice treatment, however, never use hot air. Some components may be explosive.

Unfortunately, there are no proven head lice preventatives that will keep your child from developing lice in the future. Itching is an allergic reaction to substances found in the saliva of a head louse.

Not all children will suffer itching straight on, but those who have previously had head lice are more likely to develop itching sooner. Searching for lice removal near mewill give you plenty of experts who will be able to detect and treat this behavior early on.

Joshua Merrick entered Emerson College in Boston. While in college, he started to get interested in writing articles. After a while, this work became his permanent activity, which he is engaged in to this day.

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The Best Lice Treatment Near Me - Longevity LIVE - Longevity LIVE

For over 20 years of his career, Justin Gatlin focused all his attention towards the end of a 100m sprint. He was the Olympic champion in Athens 2004, but his storied career had no dearth of controversy, as he was twice banned for doping.

He returned to his sport after completing his ban, continued to blaze through the tracks, but often fell short to a tall Jamaican sprinter called Usain Bolt who had emerged when Gatlin was away.

Yet looking back at his career, the 40-year-old, speaking virtually to Scroll.in from Bangalore where he is the ambassador for the World TCS 10K, asserted that he had no regrets and is looking fondly towards his future endeavours.

And you cant blame the American, who has won five Olympic medals (a gold, two silver and two bronze) and 10 World Championship medals (four gold and six silver), for feeling that way. He has lived through the greatest highs his sport has to offer and endured the harshest lows.

His illustrious career well describes the longevity hes enjoyed, but now that he has hung up his spikes he announced his retirement earlier this year hes ready to find another path. One that goes beyond 100 metres.

Excerpts from the interview with Scroll.in:

A few months ago you announced on social media that you were retiring. After such a long journey, why now?

I didnt want to stay in a sport feeling I was trying to squeeze water out of a rock. I wanted to be able to leave on my own accord, be able to say, my career is done, and I want to end on my own terms.

I thought it was the right move to make especially going into 2022-2023. I was already hitting 40 years. I felt great, but I think it was a time for me to move in a different direction in my life and find other passions too.

When the Tokyo Olympics were postponed due to the pandemic, was it a struggle for you to stay on with the grind for another year, prolonging the career?

Not necessarily because I had the opportunity to be able to be at multiple Olympics. I understood what it meant to be at an Olympics, I understood what it meant to win a gold medal. For me, it wasnt the pressure of the Olympics getting pushed back a year, its just a fact that I tried, I went out there and pushed as hard as I could. I had a hamstring injury going into the finals, I just couldnt make it. If I could, Id have gone out there and ran till 2023 if necessary, but it was that time for me to be able to leave the sport on my terms, and find other passions and other journeys.

Have you adjusted to retirement life? What was it like the morning after you announced your retirement knowing you dont have to go through the grind again?

I retired at the end of the season, so for me it felt like I was even till now, it feels like Im on vacation. It hasnt hit me yet that Im really not competing anymore. It feels like Ive been out of the sport for a year but I retired in February, so its only been a few months.

Im still excited about new paths, new journeys. Its brought me to India. If I was still competing, it wouldnt be feasible for me because Id be competing, in training, getting ready, the coach would be yelling at me to train more

Right now Im happy with the choice that Ive made.

What are some of the things youre looking forward to now?

Theres not a list yet, but just finding a new passion, a new adventure. Ive been doing this (sprinting) for over 20 years now, my whole adult life. I feel like Im not whole as a person because Im leaving something on the table. But I feel excited because now I can go out with friends, have fun, drink, party, not worry about standing on my legs for too long, I can go out for a walk. These are all the things you have to take into consideration when youre an elite athlete how long you stand on your feet, how much alcohol you intake, how long you stay up without getting the right amount of rest.

Now I can be able to do whatever I like to do and enjoy it. Thats going to spark some inspiration in me to find another path.

You were a part of the generation of sprinting superstars Tyson Gay, Asafa Powell, Yohan Blake, Usain Bolt. Now that everyone has retired, it seems like you all leave a void in the sprint event. Do you see it as well? Do you see another big rivalry coming up among the younger athletes?

I dont see a rivalry just yet because I think that the athletes are jockeying for position to be the elite athlete the top dog. Theyre all trying to find themselves right now. But the exciting part is you have a handful of athletes all running the same time. It makes races more exciting. You have to tune in to watch to see who is going to win. Thats something in the last couple of years, when there was me, Usain, Yohan, Asafa theres only a couple of athletes that you know is going to win the race. Now you have to watch to see who is going to win, thats whats exciting to me.

Yohan Blake had said years ago that he was born in the wrong generation. You too would have been frustrated because youre working hard, breaking the 10-second barrier, and still coming out second best to Usain Bolt.

I dont think I was born in the wrong generation. I think Im the bridge that connects generations because I raced against Maurice Green, I raced against Usain, I raced against Christian Coleman and the young guys racing now. Ive had a long stretched out career and it helped me look at track and field from a different angle and be able to say okay, this is how I need to evolve.

Along the way its given me more perspective and I have more respect for the craft now.

Outside the track, like you said you competed across generations, did you feel like the old man when you interacted with the newer generation of athletes?

You know what, I will probably say Im the poster child of being the old man in the group even though Tyson is only a couple of months younger than me. I think the fact that longevity Ive had at being at the top of my game for so long makes me the old man of the group, and I have more grey hair than the rest of them. But I take on the challenge and my mind and body is fit, I dont take age as a limitation.

With technology improving so much over the years, weve seen the new shoes being designed to shave off minutes in marathon timings. Has that made inroads in sprinting as well, and does it take away from the human element and make athletes more reliant on the technology?

I think the human element is evolving. Thats where we are as humans. Were learning from the past and trying to make the future better. With technology, I think thats the way to go. Nobody complains about faster tracks, nobody complains about better gear to wear its lighter and more streamlined. The technology for the shoes is helping athletes become more consistent across the board. I think that puts on a greater show.

Do I credit the shoe making them faster, not necessarily. But it gives them more consistency.

As the technology keeps on improving, 10 years down the line, do you think people will forget about how hard it was in your time with, say, inferior equipment?

I think well always look back and appreciate the ones that came before. I look back at Jesse Owens, who pretty much ran on cinder. He was still running very fast. He was using a small scoop or shovel to dig in the sand, he didnt have starting blocks. Being able to come from that era to the era that I was running in, is amazing to me. So the athletes in the future are going to look back and say to me, wow, you ran on rubber? You used starting blocks? Thats crazy.

Technology is always going to be the gateway for the sport to be successful.

India recently won its first gold medal in athletics at the Olympics. Do you feel that World Athletics is hoping for India to start getting bigger and better in the sport?

Absolutely. I have a lot of fans and supporters, young athletes from India who I talk to on social media who I try to give tips and inspiration. In the next couple of years youre going to see a surge of athletes coming out of India who are going to say, if its to be, why not me. Why cant I go out there and become the next best from not just my country, but the world.

Its going to take a lot, its going to take those trailblazers to take the hard path to be successful, but its going to open up the doors to the young athletes who are going to come after that.

There were some dark phases through your career when you were banned. How did you get through those, what kept pushing you?

It was a long road. I took it day by day. Day by day for four years is a long time. For me, it was discovering myself. When I was in the sport, it was a dream come true. It was a checklist Olympic gold medallist, double world champion, world record holder. And then boom, it just stopped.

I had to find who I was and at the age that I was at, I discovered that I was still a young man. As I came back to the sport I had a different perspective. When I came back I knew I had to hone in on my craft and I didnt have any time to lose because now I had to be able to work going into my 40s.

And I feel I was more successful in the second half of my career than the first part.

Because of the scandals that have taken place, is there a trust deficit in sprinting where people look at every achievement with some skepticism?

I just think its in every sport. Some sports handle it internally and some put it out in the media. I think itll always be there, thats how you keep the checks and balances of sports. At the end of the day the sport will be the sport, itll still have athletes, the fans, the young kids who want to be the next great athletes. I dont think those setbacks will determine how successful the sport will be.

Christian Coleman too had been banned from competing at the Tokyo Olympics. How does he come back from that?

He gets back on his feet by betting on himself. He knows his capabilities, he knows how successful he can be, how hard hes worked. For him its about putting that on the line. He needs to go out there and show himself and the world that he deserves to be on top of that podium. Work and discipline will show that.

With your vast experience as a sprinter, do you feel that one day youll go into coaching?

Im not going to say no to it. But to be a great coach, and in my world I strive for greatness, you have to give a piece of yourself to the athlete. What I mean by that is, youre dedicating your time and your life everyday. Youre getting up everyday as your athlete, youre going to the track everyday with your athlete. So when they win, youre happy. When they dont, youre sad because theyre sad.

Do I feel that Im in the right place emotionally and mentally to be there right now? No, maybe Ill get there in a year or two. But I find that its drawing me. When I talk to young athletes, I find myself already coaching them. Hopefully in the near future youll see me with a stopwatch in my hand.

Is there something you still miss about the grind of being an athlete?

I can tell you what I dont miss. I dont miss being sore. I dont miss being injured. I dont miss being under the hot sun, training till the point of exhaustion. What I will miss is the competition, the travelling, the culture, seeing different places, seeing my fans. Those are things Im still going to try and connect in my new journey. I want to be able to reach out and connect with my fans, and hopefully still inspire them.

In Bangalore now, youre the ambassador for a 10km event, and you were a 100m sprinter. How different does that feel?

Its a huge difference. The only way I can contribute physically is, Ill line up at the 100m mark before the finish line, Ill run the rest of the race in.

But it doesnt really matter the distance. Its about the effort, the cause. I know there are so many people out here running not just for themselves, but for a cause, and thats important.

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Justin Gatlin interview: I dont think I was born in the wrong generation - Scroll.in

Jennifer Garners character in 13 Going on 30 Jenna Rink wishes she could age more quickly. The ills of being a teenager and navigating social structures in the late-'80s are too heavy to handle and, through the power of wishful thinking and some magic dust, she gets her wish. Being 30 without the knowledge of the intervening years, however, isnt easy either. Eventually Jenna finds herself wanting to be a kid again.

Thats something many of us can probably relate to. When youre young you wish you were older, and when youre old you wish you could reclaim your youth. The secret, it turns out, isnt magic wishing dust but poop. More specifically, its the microbiota found in your digestive system.

Aime Parker from the Gut Microbes and Health Research Programme at the Quadram Institute, and colleagues, recently completed a study looking at the impacts of microbiota transplants in mice. In short, they took fecal materials from young mice and transplanted them into old mice, and vice versa, to see how their physiology was impacted. Their results were published in the journal Microbiome.

We did a transplant of fecal slurry thats spun down resulting in essentially fecal water. Its got most of the bacteria in there, as well as viruses and fungi, which we didnt specifically look at, Parker told SYFY WIRE.

The study was relatively short-lived, lasting only a few weeks, but researchers saw significant changes in the mice who received treatment. Older mice who received gut microbiota from younger counterparts experienced reversal of several age-associated deteriorations, including cognitive function and changes to the retina. In young mice who received transplants from older mice, the reverse relationship was observed. The mechanisms by which specific microbes impact the body at large arent fully understood, but researchers have a decent idea of whats happening.

Some microbe species tend to be associated with lowering inflammation or lowering obesity. They have a reputation of being the good guys. We also saw a reduction in the old mice in some microbe species which are considered pathogenic or detrimental, Parker said.

Moreover, its increasingly understood that the gut microbiome maintains open lines of communication with the brain, by way of a vast network of neurons traveling from the gut to the brain. Some microbes are capable of manufacturing neurotransmitter homologues which activate nerves in the gut before making their way throughout the body and to the brain, which is just one way microbes communicate with the rest of the body across vast biological distances.

Another potential mechanism involves metabolites the microbes produce or other microbial products which contain proteins or RNA that later get into the bloodstream, as well as impacts on the immune system driving or reducing inflammation, all of which can contribute to the collective experience of aging.

Because the study only lasted a few weeks, it isnt certain that fecal microbiota transplants have a longstanding impact on longevity, but previous studies in other animal models suggests it could. What is clear is that, at least in mice, swapping out the microbiome can extend health, if not actual lifespan.

We wanted to know if we can keep animals and ultimately people healthier for longer. Maintaining better eyesight for even a couple of extra years would be hugely beneficial, Parker said.

The research isnt yet ready for human clinical trials but human gut microbiota changes as we age, similarly to whats seen in mice. The types of microbes and their diversity decreases as we age and certain neurodegenerative disorders like Alzheimers and Parkinsons exhibit different microbiota compositions than healthy controls. As uncomfortable as they might sound, fecal microbiota transplants could improve the quality of life and potentially the duration of life, if these effects are borne out in humans.

I would say, with an abundance of caution, that I wouldnt recommend anyone runs out, grabs a young person, and makes a fecal smoothie, but its not completely unreasonable to think it might be effective. We just dont know yet, Parker said.

In fact, if were patient, we might be able to avoid the microbiota transplant altogether. Researchers are hoping to identify the specific species of bacteria and the mechanisms at work in hopes of culturing just those species or developing drugs or therapies which would have the same effect.

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The secret to long life or early aging is poop? - Syfy

By Express News Service

Develop a growth mindset

It teaches the brain to prioritise learning and, hence keeps it alive. It motivates you to know more and be better.

Acceptance

Much of the turbulence of life is a result of resistance. Learn to accept, which means simply allowing for things to be the way they are. Oftentimes, people mistakeacceptance for agreement. Acceptance is not about right or wrong. It is about not resisting.

Breakfastis a must

We have heard this umpteen times. Breakfast boosts brainpower. It kick-starts metabolism and provides energy. Having breakfast reduces the risk of several illnesses.

Coffee

Author Dan Buettner, who has researched longevity hotspots of the world such as Loma Linda, California; Sardinia, Italy; Ikaria, Greece and others, finds that people in these areas immerse themselves in the smaller things of life such as enjoying their morning cup of coffee. Doing so, adds years to your life.

Spend time with people

Human connections build and maintain health. Having a community of people you love and trust provides emotional care. It improves the immune system too.

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Live Long and Healthy - The New Indian Express