Category Archives: Genome

Interpreting Variants in Non-Coding Regions of the Genome - Lisa Brooks
May 20, 2013 - National Advisory Council for Human Genome Research More: http://www.genome.gov/27553774.

By: GenomeTV

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Interpreting Variants in Non-Coding Regions of the Genome - Lisa Brooks - Video

Genome Sequencing Program Update: Disease 2020 - Adam Felsenfeld
May 20, 2013 - National Advisory Council for Human Genome Research More: http://www.genome.gov/27553774.

By: GenomeTV

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Genome Sequencing Program Update: Disease 2020 - Adam Felsenfeld - Video

ACMG Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing
May 20, 2013 - National Advisory Council for Human Genome Research Speaker: Robert Nussbaum More: http://www.genome.gov/27553774.

By: GenomeTV

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ACMG Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing - Video

Brian Cox Preview - The Incomplete Map of the Cosmic Genome
A preview clip from the upcoming app The Incomplete Map of the Cosmic Genome featuring Professor Brian Cox discussing the role of electrons. The app features hours and hours of extensive,...

By: Trunkman Productions

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Brian Cox Preview - The Incomplete Map of the Cosmic Genome - Video

Striking a blow at foodborne diseases, the 100K Pathogen Genome Project at UC Davis announced that it has sequenced the genomes of its first 10 infectious microorganisms, including strains of Salmonella and Listeria.

"We are creating a free, online encyclopedia or reference database of genomes so that during a foodborne disease outbreak, scientists and public health professionals can quickly identify the responsible microorganism and track its source in the food supply using automated information-handling methods," said Professor Bart Weimer, director of the 100K Genome Project and co-director of BGI@UC Davis, the Sacramento facility where the sequencing is carried out.

Weimer estimates that the availability of this genomic information will cut in half the time necessary to diagnose and treat foodborne illnesses, and will enable scientists to make discoveries that can be used to develop new methods for controlling disease-causing microorganisms in the food chain.

The project is dedicated to sequencing the genomes of 100,000 bacteria and viruses that cause serious foodborne illnesses in people around the world.

In the United States alone, foodborne diseases annually sicken 48 million people and kill 3,000, according to the Centers for Disease Control and Prevention.

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UCDavis Genome Project maps infectious microbes

Colony Collapse Disorder and the WSU Honey Bee Genome Repository
A lot of challenges face honeybees. Invasive mites sap the brood #39;s strength and introduce disease. Pesticide build-up in the brood comb gradually weakens the bees. And monocultures may provide...

By: Agricultural, Human, and Natural Resource Sciences

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Colony Collapse Disorder and the WSU Honey Bee Genome Repository - Video

Infosys Consumer Genome

By: 3storeys

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Infosys Consumer Genome - Video

April Flowers for redOrbit.com Your Universe Online

The genomes of two of the most economically important forest trees in the world were released by Canadian and Swedish scientists. In Canada, the conifers supply raw materials for the forest industry, accounting for $23.7 billion of the nations economy in 2011, while the gross output of the Swedish forest industry was $29.7 billion in 2009.

Between them, the white spruce and the Norway spruce genomes have 20-30 billion base-pairs and are up to 10 times larger than the human genome, making these sequence assemblies the largest to date.

THE WHITE SPRUCE

A group of Canadian scientists, led by Professor Steven Jones, Head of Bioinformatics at the BC Cancer Agency Genome Sciences Centre (BCGSC) and a professor at both the University of British Columbia (UBC) and Simon Fraser University (SFU), sequenced the white spruce genome as part of the SMarTForests Project.

SMarTForests builds upon previous discoveries of the past decade to break new ground in spruce genome sequencing in order to represent Canada in international conifer genome initiatives and to achieve efficient translation of results toward end-users from across Canada.

Attempting the sequencing of such a large genome was an incredibly ambitious task and required the development of novel software and innovative use of DNA sequence technology to piece together short DNA sequences to form this massive genome, much like a large jigsaw puzzle, said Jones. The findings of this study were published in the journal Bioinformatics.

Many projects are now attempting to decipher genomes of economically important plants, Inanc Birol, a scientist with BCGSC and a professor with both UBC and SFU, said in a statement. We demonstrated a superior and less expensive method to do the job.

These genome sequences allow us to develop innovative tools for tree breeding, addressing economically and ecologically important targets such as insect resistance, wood quality, growth rates and adaptation to changing climate added UBC Prof. Joerg Bohlmann, a collaborator on both studies.

A genome-based marker system could serve to reduce the time of a spruce breeding cycle from currently 25 to as short as five years, and will contribute directly to the competitiveness of the Canadian and Scandinavian forest industry, said Prof. John MacKay of Universit Laval, who also participated in both studies.

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Researchers Map Genome Of Two Important Spruce Tree Species

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/5b54vr/us_personalized) has announced the addition of the "US Personalized Cancer Genome Sequencing Market" report to their offering.

The US personalized cancer Genome Sequencing market is primarily classified into Targeted Genome Sequencing and Whole-Genome Sequencing. Our report entitled US Personalized Cancer Genome Sequencing Market takes into account the Whole-Genome Sequencing services, which is one of the most attractive sectors due to its inherent capability of high revenue generation and efficiency in terms of personalized treatment.

In order to properly analyze the virtues and significance of the US personalized cancer Whole-Genome Sequencing market, our report has effectively studied the current and future status of cancer in the US as well as its States. In view of the fact that cancer affects some specific age groups in a significant manner, we have also investigated the age-wise statistics of the disease. To get proper insight into the market, an in-depth analysis into the high-income group population is provided so that players can have a clear picture about their potential customer base and the market to be tapped.

The WGS industry has evolved in US in the recent times, and the level and seriousness of implementation has seen drastic changes. An in-depth study of the regulatory environment governing the US personalized cancer Whole-Genome Sequencing market has also been provided. It has been found that regulations related to personalized cancer sequencing are primarily governed with the accreditation of the laboratories performing the sequencing services and analysis, and also the usage of FDA approved tests for conducting these tests. Further, we have also discussed the various constraints faced by the industry players with suitable suggestions to overcome them.

The report analyzes the competitive landscape in the market by properly analyzing the business, services and activities of the companies. It also provides the competitive benchmarking, taking into account the strengths and weaknesses of each player. Overall, the report is a complete source of knowledge and statistics for the clients who want to get an in-depth understanding of the market.

Key Topics Covered:

1. Analyst View

2. Research Methodology

3. Cancer Statistics by Demographics

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Research and Markets: US Personalized Cancer Genome Sequencing Market Report: 2013 Edition

Public release date: 22-May-2013 [ | E-mail | Share ]

Contact: Pr Ingvarsson par.ingvarsson@emg.umu.se 46-708-485-977 Umea University

Swedish scientists have mapped the gene sequence of Norway spruce (the Christmas tree) a species with huge economic and ecological importance - and that is the largest genome to have ever been mapped. The genome is complex and seven times larger than that of humans. The results have been published in the prestigious journal Nature.

This major research project has been led by Ume Plant Science Centre (UPSC) in Ume and the Science for Life Laboratory (SciLifeLab) in Stockholm.

In addition to its scientific interest this new knowledge has immense importance to the forestry industry in many countries.

"Forest tree breeding is now entering a new era, and Sweden has the potential to be in the forefront of development," says Professor Ove Nilsson from UPSC. "Newer and more effective methods can begin to be used to ensure that the over 200 million tree seedlings planted each year in Sweden are as strong, healthy and well-adapted as possible for both poor and rich soil areas in different parts of the country."

The scientists have identified about 29,000 functional genes, marginally more than humans have, but the question arises: why is the spruce genome still seven times larger than ours? According to the study an explanation is "genome obesity" caused by extensive repetitive DNA sequences, which have accumulated for several hundred million years of evolutionary history. Other plant and animal species have efficient mechanisms to eliminate such repetitive DNA, but these do not seem to operate so well in conifers.

"It is remarkable that the spruce is doing so well despite this unnecessary genetic load," says Professor Pr Ingvarsson at UPSC. "Of course, some of this DNA has a function but it seems strange that it would be beneficial to have so very much. This appears to be something special for conifers."

The greatest challenge in the project has been to get the approximately 20 billion "letters" found in spruce's genetic code into the correct order, rather than obtaining the actual DNA sequences.

"Imagine a library with ten thousand books as thick as the bible, written in a language with only four letters," explains Professor Stefan Jansson at UPSC. "If someone took one hundred identical copies of each of the ten thousand titles, passed them all through a document shredder and mixed all the shreds, and you then were asked to piece together an accurate copy of each title, you can realize that it can be a bit problematic."

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The Norway spruce genome sequenced