Category Archives: Eczema

BALLERUP, Denmark--(BUSINESS WIRE)--NOT FOR DISTRIBUTION IN THE UK OR IRELAND

LEO Pharma A/S, a global leader in medical dermatology, today announced it has enrolled the first adult patient in the first of two pivotal Phase 3 clinical trials with delgocitinib cream, an investigational topical pan-Janus kinase (JAK)-inhibitor, for the potential treatment of adult patients with moderate-to-severe chronic hand eczema (CHE).

Delgocitinib inhibits activation of the JAK-STAT pathway, which plays a key role in the immune system in driving the pathophysiology of chronic inflammatory skin diseases.1,2 The cream formulation of delgocitinib is an investigational therapy under clinical development and has not been approved by any regulatory authority.

The primary objective for the randomized, double-blind, vehicle-controlled, multi-center Phase 3 clinical trials (DELTA 1 and DELTA 2) is to evaluate the efficacy of twice-daily applications of delgocitinib cream 20 mg/g compared with vehicle in the treatment of adults with moderate-to-severe CHE.3,4

The primary endpoint of the trials is the Investigators Global Assessment for chronic hand eczema treatment success (IGA-CHE TS) at Week 16.3,4 Treatment success is defined as an IGA-CHE score of 0 (clear) or 1 (almost clear) with at least a two-step improvement from baseline.3,4

Key secondary endpoints at Week 16 include reduction of itch and pain scores of 4 points measured by the Hand Eczema Symptom Diary (HESD) from baseline to Week 16,3,4 as well as at least 75% improvement from baseline and at least 90% improvement from baseline on the Hand Eczema Severity Index (HECSI) at Week 16.3,4 The number of treatment-emergent adverse events per patient from baseline to Week 16 defines the key safety endpoint of the trials.3,4

"Managing moderate-to-severe CHE is challenging because of limited available treatment options for chronic use, said Dr. Sibylle Schliemann, Consultant, Department of Dermatology, University Hospital Jena, Germany and lead investigator for DELTA 2. These trials will evaluate whether delgocitinib cream can potentially offer a new treatment option for adult patients with moderate-to-severe CHE who suffer from a considerable burden of disease.

CHE is defined as hand eczema (HE) that lasts for more than three months or relapses twice or more within a year.5,6 HE is the most common skin disorder of the hands7 that affects an estimated 1 5% of the general population8 with a one-year prevalence rate of approximately 10%.9 It is an inflammatory, non-infectious skin disorder of the hands and wrists5,10 and can cause itching, blisters, swelling and pain so severe that it can impair the ability to work.5,7,11 In a substantial number of patients, HE can develop into a chronic condition.7

We have been encouraged by the positive results from the Phase 2b CHE clinical trial with delgocitinib cream and look forward to learning whether it has the potential to offer benefits to adult patients through a larger Phase 3 clinical development program, said Dr. Jrg Mller, Executive Vice President, Global Research & Development, LEO Pharma. We are committed to developing innovative therapies that may help improve the lives of patients who need more treatment options for skin diseases.

#ENDS#

About Delgocitinib

In 2014, LEO Pharma A/S and Japan Tobacco Inc. (JT) entered into a license agreement in which LEO Pharma gained exclusive rights to develop and commercialize delgocitinib for topical use in dermatological indications worldwide, excluding Japan, where JT retains rights.

In 2020, LEO Pharma completed a multi-center, randomized Phase 2b dose-finding clinical trial with twice-daily topical delgocitinib cream for the treatment of adults with mild-to-severe CHE. The company presented top-line results of the trial at the European Academy of Dermatology and Venereology (EADV) Virtual 202012 and presented the results of HECSI measurements during the trial at the American Academy of Dermatology Virtual Meeting Experience (AAD VMX) 2021.13

About LEO Pharma

LEO Pharma helps people achieve healthy skin. The company is a leader in medical dermatology with a robust R&D pipeline, a wide range of therapies and a pioneering spirit. Founded in 1908 and owned by the LEO Foundation, LEO Pharma has devoted decades of research and development to advance the science of dermatology, setting new standards of care for people with skin conditions. LEO Pharma is headquartered in Denmark with a global team of 6,000 people, serving 93 million patients in 130 countries. In 2020, the company generated net sales of DKK 10,133 million. For more information please visit http://www.LEO-Pharma.com.

References

1 Damsky W, and King BA. JAAD; 2017;76(4):736-744.

2 Virtanen AT, et al. BioDrugs. 2019;33:1532.

3 ClinicalTrials.Gov: https://clinicaltrials.gov/ct2/show/NCT04871711?term=delgocitinib&draw=1&rank=8 (Accessed May 2021).

4 ClinicalTrials.Gov: https://clinicaltrials.gov/ct2/show/NCT04872101?term=delgocitinib&draw=1&rank=7 (Accessed May 2021).

5 Lynde C, et al. J Cutan Med Surg. 2010;14:26784.

6 Diepgen TL, et al. J Dtsch Dermatol Ges. 2015 Jan;13(1):e122. doi: 10.1111/ddg.12510_1.

7 Bissonnette R, et al. JEADV. 2010;24;120.

8 Christoffers WA, et al. Cochrane Database Syst Rev. 2019;4:CD004055.

9 Thyssen, et al. Contact Dermatitis. 2010;62:75-87.

10 Menn T, et al. Contact Dermatitis. 2011;65:312.

11 Politiek K, et al. Contact Dermatitis. 2016;75:6776.

12 Worm M, et al. The topical pan-JAK inhibitor delgocitinib cream demonstrates dose response in a 16-week phase 2b trial in chronic hand eczema. Presented during the Late Breaking News session of the European Academy of Dermatology and Venereology (EADV) Virtual 2020 on 29 October 2020.

13 Soerensen P, et al. A phase 2b trial evaluating the efficacy of delgocitinib cream for the treatment of chronic hand eczema (CHE) using and validating the Hand Eczema Severity Index (HECSI). E-poster presented at the American Academy of Dermatology Virtual Meeting Experience (AAD VMX) 23-25 April 2021.

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LEO Pharma initiates the first Phase 3 clinical trial with delgocitinib cream in adult patients with moderate-to-severe chronic hand eczema (CHE) -...

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A study of the association of cognitive abilities and emotional function with allergic disorders in young women - BMC Blogs Network

Eczema is a group of skin conditions that 31 million people in the United States live with, according to the National Eczema Association. Patches of dry, leathery, or blistered-covered skin anywhere on your body are eczemas deal and its not pleasant.

Types of eczema that affect your eyes

Here are the types of eczema most likely to appear near your eyes:

Many types of eczema can form around your eyes. Youll sometimes hear them referred to as eyelid dermatitis, although eyelids arent your only eye-adjacent face spaces at risk.

We break down what types of eczema can affect your eyelids and the types of treatments that may work for you.

Super flaky eyelids? We can help you work out whether its eczema or not.

Eczema is defined as dry, red or discolored, itchy, and scaly skin. It can occur around your eyes.

When discussing eczema around your eyes, there are three noteworthy types of eczema:

Doctors sometimes refer to all three as eyelid dermatitis (when they pop up on your eyelids, obvs).

This is the most common eczema around. According to the Asthma and Allergy Foundation of America, around 16.5 million of 31 million folks with eczema in the United States have the atopic variety, and around 20 percent of kids are thought to have it, according to a 2010 research review. So yeah, super common.

Atopic eczema is what most people mean when they say eczema. Its rough patches of skin that itch, like, a lot. Obviously, theres more to atopic eczema than that but thats the tl;dr version.

Your flimsy, sensitive eyelid skin is prone to atopic eczema. It can appear anywhere though, and atopic eczema can also develop on your cheeks, nose, eyebrows, and whatever that bit of your face is called where crows feet develop.

Seborrhoeic dermatitis mainly happens on your scalp. You know the cradle cap that babies get? Thats seborrhoeic dermatitis. It presents as dry flaky skin that appears in patches.

As scalp-associated as it is, seborrhoeic dermatitis around your eyes isnt uncommon. Patches of seborrhoeic dermatitis or seborrhoeic eczema can appear anywhere around your eyes but are most common where your eyelids and eyes meet.

Also called contact dermatitis, this is an irritation caused by touching something that your skin takes a severe disliking to. There are two types.

Irritant contact eczema is from substances that negatively affect your skin no matter who you are. Poisonous plants and irritant chemicals are the most common catalysts.

Allergic contact eczema is when a flare-up happens because of something that your skin shouldnt have an issue with. The clue is in the name, but allergic contact eczema is a fancier medical term for your common-or-garden allergic skin reaction.

It can occur around your eyes because, as we all know, its embarrassingly easy to get stuff in your eyes. Makeup and swimming pool chlorine are common reasons for contact eczema in your eye region. So is jizz.

Each case of eczema is different. That being said, there are common symptoms that can appear across every type with varying degrees of severity.

Heres the eczema stuff that can happen around your eyes:

Eczema cant directly cause blindness. However, having eczema around your eyes increases your risk of eye conditions which can lead to blindness.

This risk increases the longer your eye eczema is left untreated. If youre experiencing an eczema flare-up around your eyes and start having vision problems you should consult your doctor ASAP.

Eczema isnt the only condition that can make your skin around your eyes red or discolored, swollen, and really sore.

There are a few other common ailments that present in a similar way (and in most cases develop as a result of eye eczema-based complications). Some of these are:

Theres not a definitive reason that some people develop eczema. Even with contact eczema, science hasnt discovered why some people have allergic reactions to the stuff others can touch no-problemo.

You can develop any kind of eczema due to a mix of genetic and environmental factors. There are strong hereditary links, stress can play a big part, and your immune system is also a catalyst for many eczema types.

Theres no way to test if youre at a high risk of developing eczema (aside from others in your family experiencing it). Avoiding it may be impossible for some people. There are, however, known triggers that folks at risk of eczema are advised to steer clear of where they can.

Here are some common eczema triggers to avoid if youve got sensitive skin around your peepers:

Diagnosing eczema anywhere is actually super easy. They dont need to do lab tests or anything.

Your doctor will ask you a bunch of questions if youve had eczema in other places or have had any irritants near your eyes.

Once they ask some questions, theyll tell you if its eczema or not. The only extra step is that your doctor may want to do a patch test, which exposes an area of skin to allergens, to check for a reaction.

Home remedies for eczema near your eyes

There are plenty of home remedies that can treat eczema around your eyes and take the edge off uncomfortable symptoms.

If youre prone to eczema flare-ups, there are steps you can take to manage this and reduce the risk.

There are plenty of over-the-counter (OTC) and off-the-shelf treatments for eczema available at pharmacies.

If you develop eczema due to an allergic reaction, antihistamines can help you manage the itching and swelling.

Corticosteroids can also treat eczema itching, but using them around your eyes is risky (it can lead to glaucoma, which is really serious and 100 percent worse for your eyes than eczema).

Consult your doctor before trying any OTC treatment (especially if youre already on other medications or undergoing treatment for another condition).

If home remedies and OTC medication dont do the job, your doctor can prescribe more intensive treatment. Severe and recurring eczema will probably require some kind of prescription medication.

Your eyes are pretty sensitive. This may limit the treatments your doc can offer because they want to protect your eyes condition from becoming more severe. Prescription eczema treatments that are safe to use near your eyes include:

Eczema around your eyes isnt always serious, but it can become serious without treatment. It can also lead to serious conditions, some of which can make you experience blindness.

Eye-based eczema also presents more of a risk than some other eczemas simply because of how sensitive your eyes are.

As eyes are prone to infections and protected only by a thin membrane, eczema near your eyes is more likely to cause complications than an eczema patch on your belly or butt cheek.

Theres no way to prevent eczema flare-ups completely. You can significantly reduce the risks of them developing though.

Most of the home remedies and treatments to treat flare-ups also prevent them. Steps to keep eczema flare-ups at bay include:

The three main types of eczema that mess with your eyes are atopic eczema, contact eczema, and seborrheic dermatitis. Theres no single cause: Eczema usually develops due to a mix of genetic and environmental factors.

You cant prevent eczema flare-ups around your eyes, but you can minimize the risk by avoiding known triggers.

Theres plenty of home remedies that can treat eczema around your eyes (and almost prevent it from happening again). If these dont work there are plenty of OTC and prescription treatments as next steps.

Eczema near your eyes isnt normally serious but can be without treatment so get it sorted straight away.

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Eczema On The Eyes: Causes, Symptoms, and Treatment - Greatist

Imagine youre a parent on a Saturday morning and its your turn to wake up early with the kids. Of course youre tired when you get up -- youve been tired since you became a parent!

You smile when you see them in their cute pajamas. You brush their teeth and head to the kitchen to make them breakfast while they watch cartoons. They start fighting and you go into mediator mode, while ensuring the pancakes on the skillet dont burn.

They eat happily and are messy -- as expected when you give little ones pancakes with syrup. Its time to change them out of sticky pajamas and into their outfits for the day.

Fast forward a few hours and youre tired and need a break, which you can take during nap time after you feed the kids lunch.

Fast forward more and its the evening, which means cooking dinner, feeding kids, bath time, bedtime, and the post-bedtime kid shenanigans that follow. At that point, you can finally relax until you go to bed and do it all again the next day.

Being a mom with atopic dermatitis (AD) or eczema is like that -- except youre doing it all while also being itchy. Although my daily routine and activities will change as my children grow, Ill likely always be itchy.

Eczema Can Scare Children

My children are Nico Atlas, 2, and Nina Sol, 4. I cant hide my eczema from my children. Their experience with my eczema will evolve as they get older.

Nina was a baby when she and my husband joined me at my allergists office for an allergy skin prick test on my back. This test should instead be called the skin stabbing test, because its painful! But with my baby girl next to me, I knew I had to be extra tolerant and calm to not scare her.

Throughout the years, Ive been careful to not bleed in front of her because blood can be scary for kids. Most important, Ive been open with my children about my eczema. Nina knows that I have eczema, because when she was younger she asked me why I had polka dots on my body (so cute!). I told her it was my eczema.

When Nico gets older, Ill tell him, too. Eczema shouldnt be scary, but it can seem that way to kids when theyre confused or uninformed.

Eczema Affects Your Family Activities

Chronic eczema affects my daily life. As a parent, this means my family may be affected by my condition. Do the kids want to walk outside on a sizzling hot day when my eczema is flared? Maybe well do something indoors instead.

How about getting in the pool with the children? Some days, its best to not get wet. But its OK. We just do a different fun activity that wont worsen my skin. The kids will be just as giddy.

There are, however, some activities that eczema fighters must do even if it will hurt a bit. For example, even if my forearms are flared, Im still going to give my kids a bath. This means my arms will hurt as I dip them in the water. Stinging arms arent a big deal to me when I get to enjoy watching my babies play in a bubble bath. Now, if my eczema is severe, Ill ask my husband to do the bath.

Childrens Compassion Helps

One of the wonderful perks of being a parent to little kids is being showered by their unconditional love and affection. Since my daughter was almost 3, she showed deep empathy and support for me when I was itchy.

At a very young age, she began telling me that I shouldnt scratch and should tap instead. (Only my adorable toddler can tell me not to scratch!) Last year, my back was unbearably itchy during an allergy patch test and Nina was especially supportive, checking in on me and asking when the test would be over. My 4-year-old helped me get through gruesomely itchy 4 days.

Having chronic eczema can be hard as a mom, but the support from my adorable cheerleaders makes me stronger. I also keep things in perspective with gratitude. I focus on the special moments with my children. Ultimately, Im most grateful that its my body with eczema and not my childrens skin. I am, after all, a mother above all and want the best for my babies.

What Ive Learned

Choose products like shampoo, soaps, and moisturizes for your children that you can tolerate. That way youll avoid flare-ups on your skin when you use them on the kids.

Photo credit: Anastasia Malachi/iStock via Getty Images

WebMD Blog

Helen Pia has lived with chronic atopic dermatitis (eczema) and skin allergies for most of her life. Shes committed to offering support, advice, and compassion to fellow eczema fighters through her Itchy Pineapple blog. Pia is married with two young children and is a marketing leader in the B2B tech industry. She lives in Houston, TX.

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What It's Like to Be a Mom With Eczema - WebMD

Medina Spirits win in the 147th running of the Kentucky Derby presented by Woodford Reserve remains in question after a postrace blood test indicated the presence of betamethasone, a corticosteroid prohibited in horse racing.

Medina Spirit, a 3-year-old colt trained by Bob Baffert for owner Amr Zedans Zedan Racing Stables, went wire to wire under jockey John Valazquez to win the Kentucky Derby on May 1 at Churchill Downs, in Louisville, Kentucky. The Derby win, a record seventh for Baffert, could be overturned if a second round of testing, known as a split sample, also shows the presence of betamethasone.

The Racing Medication and Testing Consortium states that betamethasone is widely used in equine veterinary medicine as a steroidal anti-inflammatory. Several equine products approved by the U.S. Food and Drug Administration include betamethasone for intra-articular use in joints to control pain associated with inflammation and osteoarthritis.

According to the Kentucky Horse Racing Commissions April 2020 drug withdrawal time guidelines, betamethasone may be administered intra-articularly up to 14 days prior to a race. The acceptable threshold level was reduced from 10 picograms per milliliter (mL) in serum or plasma to zero in August 2020. Medina Spirits test showed 21 picograms per mL.

Reactions to the positive test were swift.

The Jockey Club, the breed registry for the Thoroughbred in the United States and Canada, also issued a statement that read in part: We sincerely hope justice is swift, sure, fair, and uniform. Bettors and fans need to have unshakable confidence in the integrity of the sport. The passage of the Horseracing Integrity and Safety Act (HISA) undeniably will give our sport a far better level of regulation.

On May 11 Baffert issued a statement through his lawyer, Craig Robertson III, stating that Medina Spirit had been treated for a skin condition with Otomax, a topical ointment labeled for dogs containing betamethasone, for dermatitis. Physicians often prescribe betamethasone topically to treat a variety of skin conditions including eczema, dermatitis, rash and allergies in people.

Baffert is currently suspended from Churchill Downs pending the results of the split sample. Medina Spirit has moved on to Pimlico Race Course, in Maryland, where he will be allowed to compete in the Preakness Stakes on Saturday, May 16, as long as a prerace drug test is negative.

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Kentucky Derby Winner Tests Positive for Betamethasone The Horse - TheHorse.com

- Low side effects and versatility of traditional Chinese medicine for skincare drives the market growth.

NEW YORK, May 11, 2021 /PRNewswire/ -- As per a study by Fact MR, the global traditional Chinese medicine for skincare marketis forecast to exceed the valuation of US$ 7 Bn over the duration of 2021 to 2031. According to the study, growing demand for acupuncture and various Chinese herbal medicines from developing countries is boosting sales. Engagement of modern manufacturing methods and traditional medicines along with flooding investment towards developing better medicines will drive the market sales for the forecast period.

According to a report published by the American Academy of Dermatology titled "Skin Conditions by the Numbers", annually around 50 million Americans suffers from acne skin condition. Soaring number of skin acne patients is propelling the global market demand. COVID-19 pandemic did slow the traditional Chinese medicine for skincare market but with relaxation in trading, a steady recovery is on the card.

"Traditional Chinese medicine is gaining popularity among emerging economies for its low cost and high effectiveness. Lack of safety regulation for manufacturing and approval of such medicines is slowing the traditional Chinese medicine for skincare market growth", said a lead analyst at Fact.MR.

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Key Takeaways

Prominent Drivers

Key Restraints

Discover more about the traditional Chinese medicine for skincare market with 85 figures and 48 data tables, along with the table of contents.

https://www.factmr.com/report/traditional-chinese-medicine-for-skincare-market

Competitive Landscape

Leading players operating in traditional Chinese medicine for skincare market profiled by Fact.MR include Integrated Chinese Medicine Holdings Ltd., Solstice Medicine Company, Inc., The Mentholatum Company, Yuannan Baiyao, Shanghai Jahwa United Co., Ltd., Eu Yan Sang.

Manufacturing and diversify the range of products is the main area of focus among the key market players. High competition is pushing leading players to develop innovative products for strengthen their market hold.

For instance new range of Qianding Yunzhi, Qianding Yunzhi Family Pack was launched by Integrated Chinese Medicine Holdings Ltd.

New range of Beanne Extra Pearl Cream, Sanjin Uroplex Tablets was launched by Solstice Medicine Company, Inc.in 2019.

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More Valuable Insights on traditional Chinese medicine for skincare market

Fact.MR, in its new report, offers an unbiased analysis of the global in traditional Chinese medicine for skincare market, analyzing forecast statistics through 2019 and beyond. The study reveals growth projections on in traditional Chinese medicine for skincare market on the basis of Product type (Traditional Chinese Herbal Medicines, Traditional Chinese Herbal Medicines for Acupuncture, Diet Therapy), Application (Traditional Chinese Herbal Medicines for Eczema, Traditional Chinese Herbal Medicines for Psoriasis, Traditional Chinese Herbal Medicines for Acne, Traditional Chinese Herbal Medicines for Hyperpigmentation) across regions (North America, Latin America, Europe, South Asia, East Asia, Oceania, MEA).

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Versatility of Traditional Chinese Medicines Make it highly Sought-after in Skincare: Fact .MR - PR Newswire UK

The benefits of avocado dont end with just its ingestion as its topical application has been shown to soothe existing skin conditions like eczema and acne; improve skin elasticity, giving the skin a youthful appearance, and promote the production of collagen and protect from free radical damage, the major cause of skin and hair damage and decay.While a number of researches show varying results and findings on how avocado oil-based products help with our skin, the top few benefits that matter to us would be. Anti-aging propertiesAs we age, our natural oil as well as collagen production decreases making skin dryer, rougher, and less youthful. Using avocado oil for face wrinkles is a very good option. When used topically, its known to combat skin dryness and may also boost collagen production.Fights free radicals

Free radicals not only contribute to disease, but they also contribute to all kinds of unwanted skin changes including age spots, wrinkles and more serious concerns like skin cancer. With its rich content of nutrients and antioxidants, avocado oil may be able to help fight free radical damage when applied externally and reduce chances of unwanted skin changes including age spots, wrinkles, and more serious concerns like skin cancer caused due to free radicals

Helps soothe sunburnSince avocado oil is rich in vitamin E, beta-carotene, vitamin D, protein, lecithin, and fatty acids, it makes it a great addition to natural after-sun products to help soothe the skin and reduce the negative effects of sunburn.

Helps with inflammation reduction and skin irritation

The rest is here:
Beauty benefits of avocado oil - Times of India

Happiness is having a scratch for every itch. Ogden Nash

Itching is a common problem. Notice the dog furiously digging his fur with a hind leg or farm animal rubbing up against a tree or post. I similarly admit to often using the nearest door frame to scratch a persistent itch in my upper back.

As a primary care doctor, I treat many itching people. The medical term is pruritus. Usually, its a straightforward problem requiring little more than moisturizing or medicating a rash with over-the-counter salves, hydrocortisone or antihistamine creams or oral antihistamines.

So, what about the itch without a rash or the itch that doesnt go away? This is chronic pruritus. One of my patients, a delightful widow lady from Australia, is afflicted with a highly annoying itch on her upper back, at about the same place as mine.

Hers is more irritating, intrusive, continuous and significantly decreases her quality life. Its thought to be due to an irritated or entrapped nerve, a condition called notalgia paresthetica. She has visited all kinds of doctors, tried many topicals, oral medications, botox injections, acupuncture and even considered surgery without relief.

Rashless itches also can be a sign of underlying and serious disease. Chronic problems with the kidneys, liver, blood, thyroid and certain malignancies can lead to generalized itching. One peculiar challenging psychiatric problem is delusional parasitosis in which a person, against all evidence to the contrary, believes they have miniscule insects or parasites invading their skin.

These unfortunate folks often dig deep scratches and ulcers into their skin probing for their invisible, non-existent tormentors. Other psychiatric causes of pruritus include obsessive compulsive or bipolar disorders, anxiety, depression and schizophrenia.

Besides notalgia paresthetica, other neurological causes of itching include strokes, shingles, diabetes, compressed nerves, multiple sclerosis, among others.

Many dermatological conditions like dry skin, eczema, psoriasis, hives, contact dermatitis, and allergies cause chronic or intermittent pruritus.

When in doubt, see your primary care doctor or dermatologist. How we treat you will vary according to the cause of the itching, such as diagnosing and managing an underlying disease or removing a provocative cause. Laboratory work and imaging may be required.

A broad variety of anti-itch remedies are available. These can include steroids taken topically or orally, anti-histamines, nerve medication gabapentin, moisturizers, capsaicin cream, anesthetics such as lidocaine in a cream or patch, calcineurin inhibitors for psychogenic itch, psychiatric medications or phototherapy with ultraviolet A and B light.

Numerous traditional, herbal folk medicine remedies for itching include: marigold, chamomile, oatmeal baths, tea tree oil, slippery elm, marshmallow root, aloe, comfrey and witch hazel.

Always consider non-drug therapies for itching: taking baths in warm not hot water, applying emollients right after bathing to keep moisture in the skin, using hypoallergenic skin products, identifying soaps, detergents or other irritating substances, noticing association with certain foods, wearing cotton instead of wool, choosing loose fitting clothes, humidifying indoor spaces in the winter, avoiding excess sweating and managing stress as one more thing that makes itching worse.

Dr. Victor S. Sierpina is the WD and Laura Nell Nicholson Family Professor of Integrative Medicine and Professor of Family Medicine at UTMB.

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Do you have an itch you want to scratch? - Galveston County Daily News

A local mum who was determined to heal her newborn babys eczema has debuted her vegan skincare range in H Beauty today (29/4).

Shalom Lloyd, a pharmacist from Milton Keynes, developed her own skincare range calledNaturally Tribal Skincare in 2014, after giving birth to twins.

Almost instantly her son, Joshua, suffered from extreme eczema and itchy irritation. Shalom couldnt bear the idea of smothering his sensitive newborn skin with chemicals and steroids. Instead, she looked to her African heritage for inspiration.

Recalling recipes containing all-natural ingredients, which have been used in Africa for generations, the busy mum started to experiment in her kitchen and soon Joshuas skin cleared and Shamon now boasts products that help with Psoriasis, Dermatitis and Rosacea too.

Shalom has put these ingredients intoNaturally Tribal SkincaresImperfectly Perfect range, which made its debut at H Beauty in the centre:mk upon the store's grand opening.

Although made here in the UK, Naturally Tribal Skincare, sources high-grade Shea Butter from Nigeria. The brand has also been a Vegan Trademark holder since 2017.

The Shea industry in Nigeria has over 16 million African women collecting and processing shea kernels as a main source of income and in 2020, Naturally Tribal built and opened the Essan factory which currently employs 20 local women.

Reacting to the announcement, founder Shalom Lloyd said: This wonderful milestone brings my proud dual British and African heritage to life. We know we have great products that work and we are built on incredibly strong values. We know that we are a company that is diverse. So, being part of the H beauty Milton Keynes Born & Bred line up is something to be extremely proud of.

Having the Vegan Trademark also makes a huge difference and lets our customers know that what theyre buying is completely natural and free from animal ingredients and testing.

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Milton Keynes mum's natural skincare range that cured her son's eczema is being sold at H Beauty in Milton Keynes - MKFM

A systematic review and network meta-analysis of systemic atopic dermatitis therapies suggest upadacitinib, abrocitinib, and dupilumab are associated with the best efficacy outcomes among the robust drug class options.

The research, presented at theAmerican Academy of Dermatology (AAD) Virtual Meeting Experience this weekend, provides a unique comparison of systemic agents for key outcomes in moderate to severe atopic dermatitis treatment, including Eczema Area Severity Index (EASI) and Investigators Global Assessment (IGA) scores.

Led by Jonathan I. Silverberg, MD, PhD, MPH, of the George Washington University School of Medicine and Health Sciences, investigators conducted a systematic literature review and a network meta-analysis of randomized controlled trials observing systemic therapy in adults and adolescents with atopic dermatitis.

As they noted, head-to-head systemic therapy trials are lacking in atopic dermatitis. They hypothesized a meta-analysis could provide comparative context into the efficacy and safety of such agents and could even inform clinical decisions.

The Pfizer-sponsored assessment observed both monotherapy and combination systemic therapy in published research for atopic dermatitis. Silverberg and colleagues conducted analysis of randomized controlled trials including adult and adolescent patients through October 24, 2019.

Short-term efficacy, defined as 12-16 weeks of systemic therapy for EASI and IGA responses, as well as safety data were analyzed in fixed-effects and random-effects Bayesian network meta-analysis models.

The team found 19 published phase 2 or 3 randomized controlled trials involving abrocitinib, baricitinib, dupilumab, lebrikizumab, nemolizumab, tralokinumab, and upadacitinib.

In monotherapy use, once-daily 30 mg upadacitinib was associated with the numerically highest rate of treatment efficacy (51.6% achieving EASI 90), followed by once-daily 200 mg abrocitinib (39.2%), once-daily 15 mg upadacitinib (34.5%), biweekly 200 mg dupilumab (27.6%), and once-daily 100 mg abrocitinib (22.2%).

In combination therapy use, the abrocitinib regimen was associated with a 48.7% rate of EASI 90. Other efficacious combination systemic therapy regimens included dupilumab (41.7%) and once-daily 100 mg abrocitinib (37.9%).

Investigators observed consistent benefits in IGA and patient-reported outcomes with the systemic therapy regimens.

Treatment-emergent adverse events were more common in every active treatment regimen than in placebo, aside for biweekly 300 mg dupilumab (OR, 0.96; 95% CI, 0.45 2.18) and once-daily 100 mg abroctinib (OR, 0.95; 95% CI, 0.35 2.66), both used in combination therapy for atopic dermatitis.

The investigators concluded the assessment showed favor on efficacy and safety marks to both monotherapy and combination abrocitinib and dupilumab among other atopic dermatitis systemic therapies.

To conclude, abrocitinib, dupilumab, and upadacitinib were consistently the most effective systemic therapies in adults and adolescents with atopic dermatitis, Silverberg said. Abrocitinib and dupilumab combination therapy demonstrated the greatest efficacy, and there was no significant difference in treatment-emergent adverse events in these short-term randomized controlled trials, although there were some numerical increases observed.

The study, Comparative Efficacy and Safety of Systemic Therapies Used in Adult and Adolescent Moderate-to-Severe Atopic Dermatitis (AD): A Systematic Literature Review (SLR) and Network Meta-Analysis (NMA), was presented at AAD VMX.

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What Are The Best, Safest Systemic Therapies for Atopic Dermatitis? - MD Magazine