Category Archives: Eczema

Ok, making a milk bath sounds pretty simple, right? And, it is, except the primary key is knowing which milk to bathe in. If you are lactose intolerant, it's best not to sit in cow milk, as the last thing you want to do is cause an allergy flare up when you're currently suffering from dry skin. That said, Good Housekeeping confirms you can usemilk alternatives such as oat milk or goat milk in your bath. Verywell Health added that goat milk is a better alternative to the cow milk typically used in milk baths, as it provides a creamier feel on your skin due to the milk's high fat.

Now that you know which milk you're going to use, it's bathing time. The first step is to add 2 cups of milk, 1/4 cup of honey, and a few drops of oils to your warm water. Then it's soaking time. Dr. Henry warned that you should only soak for up to 30 minutes andtake milk baths a maximum of once a week. Yes, we know it may be tempting to bathe in milk to get rid of that dry skin feeling, but you don't want to overdo it.

Excerpt from:
Can Milk Baths Be Used To Treat Psoriasis? - The List

Rashes are part of childhood: heat rashes, diaper rashes, allergic reactions you name it and parents have probably seen it. Eczema is one of the more common rashes of childhood.

This article describes how eczema can look on a childs face, what can trigger an eczema flare, and what can be done to prevent and treat the condition.

In babies, eczema often appears on their cheeks and scalp. Up to 60 percent of people with eczema first have symptoms as babies and up to 90 percent first develop the condition before age 5, per 2017 research. Eczema is not contagious. It cannot be passed from one person to another by touching.

Eczema on a childs face often looks like irregular dry patches or a scattering of tiny red bumps. On Black and Brown skin, eczema often looks like darker brown or purple patches.

Read this article for more information about eczema in People of Color.

Sometimes pustules or whitish bumps can appear on both light and dark skin tones. Eczema patches may also look scaly and thicker than healthy skin.

You can usually see eczema on a babys face. It often looks like:

In addition to the face, eczema can also appear on the outsides of arms and legs on babies and toddlers. It can sometimes be found on the abdomen and chest, but that isnt very common.

In teens, rashes may show up on elbows, hands, necks, and feet. Eczema on the face is rare among older children and teens.

Eczema is very itchy. In some cases, the itching can be so severe that it disrupts a childs sleep and makes them irritable. They may also feel embarrassed about it.

Eczema is an inflammatory condition. The cause is linked to a gene mutation that affects the skin. Many things can make eczema worse, such as food, pollen, and other allergens.

Conditions that may lead to eczema include:

Your skin has a thin protective layer meant to keep invaders out and water in. One of the most important elements in your skin barrier is the protein filaggrin.

People with eczema may not make enough filaggrin. As a result, too much water escapes, and too many irritants and germs get in.

Your immune system helps protect you from illness and heal from injuries. In people with eczema, the immune system may react too strongly to allergens and things that are irritating. It may send out a surge of antibodies that cause a lot of inflammation in your skin.

The National Eczema Association estimates that 9.6 million children in America have eczema, which is also known as atopic dermatitis.

Doctors and other healthcare professionals usually diagnose it by looking at the rash and asking questions about triggers and other symptoms like itching.

Its possible that allergy testing, such as skin prick or scratch tests, may be needed to make sure the rash isnt caused by an allergic reaction.

Treatment for facial eczema in babies and children ranges from simple at-home changes to bathtime routines to prescription medications, according to 2017 research. What your child needs will depend on the severity of the condition and your childs age and overall health.

Here are some common treatment options:

To relieve dry skin and repair the skin barrier, you can use emollient-rich moisturizers daily. Its a good idea to talk with your childs pediatrician about how often to moisturize and which brand to use.

Many pediatricians recommend lotions with ceramides and other ingredients that build up the skin barrier.

Many health experts recommend quick daily baths (around 10 minutes) in warm water. If you use a cleanser, make sure it is free of fragrances and irritating soaps. After the bath, pat gently with a soft, clean towel and apply moisturizer.

Sunlight and narrow band ultraviolet (UV) light have been used to treat eczema successfully. Youll need to speak with your childs doctor to decide whether light therapy, which is also called phototherapy, would be a good way to treat eczema on your childs face.

Heres more information about how phototherapy is used to treat eczema.

Your childs healthcare professional may prescribe a cream, gel, or foam that contains steroids to reduce inflammation.

Steroid treatments should not be used long-term because they can make the skin thin and more vulnerable to damage. If youre using a corticosteroid cream, make sure youre only dabbing it on the areas directly on eczema lesions, not on the whole body.

Biologics are treatments options made from natural substances. Dupixent (dupilumab) is a biologic medication that may be prescribed to help treat severe eczema. In 2019, the Food and Drug Administration (FDA) approved the use of Dupixent for children 6 years and older.

Researchers have found that several factors are associated with a higher risk of developing eczema as an infant, toddler, child, or teen. These include:

Theres a lot of overlap in several of these conditions.

For example, researchers know that eczema tends to get worse during times of the year when hay fever happens, per a 2021 study. Eczema symptoms for people with darker skin tones also tend to get worse during outdoor allergy seasons.

Eczema on a childs face may go away, but it is likely to flare up from time to time throughout childhood and even into the adult years. For many people, eczema is a lifelong inflammatory condition.

Later in childhood and in the teen years, it will probably show up on hands, wrists, and skin covering joints. In people of African ancestry, eczema often affects skin that extends, such as the backs of elbows, according to 2021 research.

Treating eczema early in childhood can lead to better outcomes later, argue the authors of a 2021 article. Its also important to treat eczema symptoms because it can become infected with a secondary bacterial infection if a child scratches too much and causes open wounds in the skin.

Eczema is a chronic skin condition that often shows up on the cheeks and scalp in babies under 1 year old.

On darker skin, facial eczema can look like purple, brown, or gray patches. On lighter skin, the rash looks red. Broken skin might ooze a clear fluid. Eczema is itchy on all skin types.

Treating eczema early is important because it could reduce the severity of the condition later on. Try short, warm, daily baths followed by lots of moisturizer. Avoid harsh soaps and ingredients that can dry out the skin even more.

Your childs healthcare professional could also prescribe medicated creams to help heal irritated patches. Light therapy could also help.

Eczema may come and go as your child gets older. It probably wont show up on the face after infancy, but during flare-ups, it could appear on hands, elbows, knees, necks, and feet.

Here is the original post:
Eczema on Child's Face: Causes, Diagnosis, Treatment, and More - Healthline

If you or someone you know has been a victim of eczema (atopic dermatitis), aka itchy, red and inflamed patches of skin and one of the most annoying and stubborn skin conditions around, then keep reading because we might have some relief for you.

Joshua Zeichner, a New York City-based board-certified dermatologist, previously spoke to HuffPost about what is really going on when these unwelcome rough spots crop up. With eczema, the skin barrier is not working as well as it should be, resulting in loss of hydration and disruptions in the outer skin layer, Zeichner said.

Often brought on by colder weather, stress, genetics or contact with irritants, eczema is caused by a deficiency in one of the proteins that makes up the top layer of the skin. When theres a mutation in the proteins that holds the cells of the top layer together, the cells start falling apart, and the skin cant act as a protective barrier, Julie Russak, a board certified dermatologist and fellow of the American Academy of Dermatology also previously told HuffPost.

According to pediatric nurse practitioner Sam Casselman, this means that when looking for products to help with your eczema symptoms, formulations that help prevent moisture loss and repair the skins barrier may be able to help.

In general, you want to choose a product that has very few ingredients in it and ideally one that contains ceramides. Those are the proteins which repair the skin barrier and relieve dry skin, so use that moisturizer as often as possible. For more severe dry skin, get a thicker alternative with a petrolatum base, Casselman said.

You can read more in depth about what Casselman and our other experts had to say about eczema. But below, check out a list of cleansers, creams, detergents and more, put together with the help of these dermatologists, as well as The National Eczema Association.

HuffPost receives a share from retailers on this page. Every item is independently selected by the HuffPost Shopping team. Prices and availability are subject to change.

A rich cream that contains an essential ingredient for healing eczema

Get it from Amazon for $16.08.

A large room humidifier to maintain moisture levels in the air

The Miro humidifier takes a reassuringly sanitary approach with its easy-to-clean modular design that can be disassembled so you can reach every area that water has touched. The BPA-free, food-grade plastic adds to the safety of this fourth-generation model. It powerfully emits enough atomized mist to fill a 600-square-foot room and features an automatic shutoff feature.

Get it from Amazon for $139.

A skin protectant that, after all these years, is still a dermatologist favorite

This classic protective balm works by preventing moisture loss from the skin, giving eczema an opportunity to heal. This economical pack contains two 13-ounce containers.

Get it from Amazon for $9.76 (pack of two).

A hand soap that's free from ingredients that can cause contact dermatitis

Get it from Pipette for $5.

A sunscreen that won't make eczema worse

Get it from Amazon for $14.62.

A gentle body wash that won't strip the skin

This unscented and sulfate-free body wash is also PH-balanced to prevent any disruption to the skin's microbiome.

Get it from Target for $6.99.

A facial moisturizer that can help repair the skin's barrier

Get it from Sephora for $38.

A shampoo and conditioner that can soothe an itchy, flaky scalp

Get the pair from Amazon for $35.25.

A relaxing way to soothe irritated skin

Get it from Amazon for $9.42.

A long-lasting cream that can relieve itch and inflammation

This Cerave anti-itch cream uses 1% hydrocortisone, an essential ceramide complex and niacinamide to help ease redness and strengthen the skin's barrier function.

Get it from Amazon for $8.16.

A laundry detergent that won't cause an eczema flareup

This hypoallergenic and dye-free liquid detergent excludes potential skin irritants and is compatible with all washing machines and temperatures.

Get it from Target for $8.79.

A nourishing body cleanser filled with skin-loving oils

Get it from Glossier for $18.

A hand cream that can address five symptoms of eczema

Get it from Target for $3.99.

A simple ingredient baby wipe that you can use anywhere

See the rest here:
The Best Products To Treat Eczema This Winter, According To Dermatologists - HuffPost

Since it is a natural compound, it offers exciting health benefits without the downsides of synthetic products that are often full of harmful chemicals.

CBD oil has become an essential ingredient for beauty enthusiasts who want to experience some relief from an existing skin condition. Similarly, people who want to maintain their skin are switching to CBD skincare products.

While research clearly shows that CBD has multiple health benefits, its important to understand what it can do for your skin.

Cannabidiol, abbreviated as CBD, is a natural component found in cannabis plants like hemp and marijuana. Unlike THC, CBD has no psychoactive properties.

Different species of cannabis plants have different amounts of CBD. However, the hemp plant contains high amounts of CBD, making it more suitable for extraction. Manufacturers use various methods to extract this compound from the plants before mixing the extract with carrier oils to make CBD oil.

However, its important to understand that hemp seed oil is different from CBD oil. While the two product names are often interchanged for marketing purposes, they differ significantly. Typically, CBD oil contains very high amounts of cannabidiol compared to hemp seed oil, which has trace amounts of cannabidiol.

CBD oil products available on the market come in different concentrations that people use in various ways. Ideally, you can use it as a topical application on the skin, put a drop under the tongue, or mix it with body lotions.

According to research, the body contains cannabinoid receptors that play a vital role in various body processes. As a result, CBD has become an important product for the health and beauty industries.

Studies on the benefits of CBD on the skin are still in their early stages. However, researchers have uncovered interesting facts for anyone who wants to enjoy the revitalizing properties of CBD oil.

CBD boasts significant antioxidant and anti-inflammatory properties. Notably, full-spectrum CBD oil is also well-endowed with vital nutrients that promote healthy body functions.

The skincare benefits of CBD come from its interaction and relation to the bodys endocannabinoid system (ECS). The ECS is responsible for maintaining a healthy balance between organs and body functions. Since the skin has cannabinoid receptors for the ECS, CBD oil can interact with the system and enhance its balance.

Mostly, skin problems stem from system imbalance and often manifest as inflammation. CBD oil can signal the ECS and help restore the equilibrium necessary for healthy skin.

Inflammation is responsible for causing and accelerating most skin conditions. According to studies, the endocannabinoid system is responsible for managing inflammatory responses in the body.

Further research into the anti-inflammatory properties of CBD oil shows that it is effective in treating and preventing several skin problems. It was also found to be safer than conventional medications like corticosteroids.

The beneficial effects of CBD come from its interactions with CB2 receptors found in the endocannabinoid system. When CBD reaches your skin cells, it activates the receptors, which then balance cell communication with the bodys immune system. In turn, this effect suppresses inflammation, reduces swelling, and prevents redness.

Regular use of CBD oil can help keep skin inflammation at bay and prevent associated skin problems.

Most skin aging stems from excess exposure to ultraviolet rays and sunlight. Lifestyle factors like unhealthy diets, pollution, and stress can also make people develop skin wrinkles prematurely.

CBD is a natural plant-based nutrient containing high amounts of antioxidants vital for combating visible signs of aging. The antioxidants repair tissue damage by free radicals and reduce the amounts of free radicals in the body. It also helps the body regulate harmful free radicals that come from body processes.

Anti-aging products infused with CBD oil contain anti-inflammatory effects, which can help make wrinkles less visible. It can also help reduce skin ruddiness and dull tones.

Acne is among the most common skin problems people experience at various stages in life. This skin condition appears when the skin sebum (the waxy substance secreted by your sebaceous glands) mixes with dead skin cells and dirt. When these pollutants are trapped in the skin pores, they cause clogging, leading to acne formation.

Primarily, acne has various causes, but using substances that contain anti-inflammatory properties can reduce its severity. Several scientific studies show that CBD oil has high levels of anti-inflammatory compounds. Therefore, people with acne problems can prevent breakouts with the regular application of CBD products.

CBD oil can protect your skin from several types of acne due to its propensity to regulate sebum secretion. It works by inhibiting the production of excess oil sebum hence controlling acne outbreaks.

Another significant factor causing acne is cytokines. CBD skincare products set off a healthy anti-inflammatory reaction chain in cells that are prone to cytokines. This mode of action prevents the formation of acne. Most importantly, its antifungal and antibacterial properties help prevent infections from pollutants and dirt.

CBD products are known for their soothing compounds that have a soothing effect on your skin. The properties can help reduce sensitivity problems like skin reactivity and redness. Since all skin types are prone to the impacts of environmental stressors, CBDs soothing properties can be beneficial to everyone.

Most importantly, Joy Organics creams and lotions contain a rich profile of substances and nutrients that are essential for nourishing and moisturizing the skin. As such, it can help prevent skin issues like roughness, peeling, cuts, and cracks. The anti-inflammatory compounds are great for repairing skin damage resulting from sensitivities.

Eczema is a severe skin problem that is associated with cracks on some patches of the skin. Later, the ailing parts often become inflamed, turn red, and itchy. This skin condition can be quite embarrassing and stressful for the patient since it is very unpleasant. In fact, Eczema is a prevalent skin problem affecting 32% of Americans.

CBD oil can help alleviate the effects of Eczema thanks to its anti-inflammatory properties and the ability to relieve skin dryness. Unlike other treatment options, CBD is an effective solution since it reverses the skin condition without undesirable side effects. And since it has an intrinsic interaction with the bodys endocannabinoid system, it can help control allergic inflammations that cause Eczema.

Psoriasis is a problematic autoimmune condition that often infects healthy skin cells in the body. It works by accelerating the normal life cycle of healthy skin cells by stimulating a rapid multiplication of the cells found on the skin surface. This effect creates multiple patches of abnormal skin, red spots, and unsightly scales.

CBD triggers an interaction with the CB2 skin receptors of the endocannabinoid system and streamlines message delivery. This effect helps reduce miscommunication between the skin cells and the immune system, thus helping prevent and reversing Psoriasis. Also, it can ensure healthy and balanced multiplication of skin cells which restores natural skin conditions.

There are several ways of using CBD for skincare, depending on the issue you are dealing with.

If you want to treat a localized skin problem, you might want to approach it from the outside. As such, CBD-infused topicals like lotions or creams are a great option. Topical applications work through interaction with CB2 receptors in the skin to relieve unpleasant symptoms.

When you have a skin condition that originates from imbalances within your body, its best to go for capsules, CBD oil, or other edibles. However, some people opt for CBD vapes as they offer higher cannabidiol concentrations in the body.

Since there are plenty of CBD products on the market today, its essential to understand how to choose the best options. Here are a few pointers:

Skin problems can cause discomfort and adverse effects on the quality of life. Unlike most synthetic products for skin beauty, Joy Organics CBD can solve various skin issues without causing harmful side effects.

As a result, its possible to add CBD to your skincare routine without serious health concerns. Besides fighting skin inflammation, CBD-infused products can help in skin regeneration for healthy and glowing skin.

Read the original here:
6 Uses and Benefits of CBD On Skin - City Watch

Christopher Cooney, 38, abused the girl when she was aged nine by placing her hand on his penis after convincing her help treat his skin condition.

He then attacked the victim for a second time four years later when he plied her with alcohol and committed a horrific sex act on her at his Edinburgh home.

The terrified girl was left ashamed and embarrassed but bravely confided in a family member last year and Cooney was arrested.

Cooney pled guilty earlier this year to sexually assaulting the girl on two occasions at Edinburgh Sheriff Court.

Lawyer Ross Gardner, defending, said he had committed undoubtedly awful offences and that he was full of self-hatred at what he had done.

He said Cooney had been forced from his home due to press coverage following his guilty plea and he will probably never have contact with the victim again.

Sheriff Donald Corke described the offences as no greater breach of trust and said in his view there was no alternative to a custodial sentence.

Cooney was jailed for two years and placed on the Sex Offenders Register for 10 years.

Previously the court was told Cooney first targeted the girl when she visited his home at the capitals Broomhouse on an occasion between 2010 and 2012.

Fiscal depute Anna Chisholm said: She was at the locus and walked into the accuseds bedroom. She found the accused lying naked and face up in his bed.

The accused suffered from eczema at the time and the complainer recalls he asked her to rub cream on his inner thighs and over the top of his leg.

The complainer agreed to do this. But whilst she was doing this the accused took hold of her hand and placed it on his penis.

The court heard the assault lasted around 30 seconds and the victim later said she had felt ashamed and embarrassed by what had Cooney had done to her.

The schoolgirl suffered a second sexual assault by Cooney in 2016 while she was at his home with her parents permission.

Cooney gave her bottles of Smirnoff Ice before they watched a movie together when he assaulted her..

The court heard the attack on the child left her in shock and unable to move and afterwards Cooney was said to have acted like nothing had happened.

The fiscal said the girl bravely confided in a family member in April last year but recalling the attacks had left her very upset and was hyperventilating.

Cooney pleaded guilty to sexually assaulting a girl, aged nine, by compelling her to rub cream on his inner thighs and place her hand on his penis on an occasion between December 1, 2010 and September 20, 2012.

He also admitted to sexually assaulting the 13-year-old by placing his hands down her shorts and underwear between August 1 and 30, 2016.

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Excerpt from:
Edinburgh crime: Pervert used eczema excuse to get schoolgirl to rub his body with cream - Edinburgh News

This isnt even close: Station Eleven is the best new TV show of the year. Its haunting, gorgeously made, heartfelt, an end-of-the-world vision that lifts you up as much as it gives you nightmares. It may also be the years hardest show to recommend. Will you watch a 10-episode series in which the globe is decimated by a novel flu strain?

But Station Eleven, which is based on the 2014 bestselling novel by Emily St. John Mandel, and made by the writer Patrick Somerville (who wrote Netflixs Maniac, and wrote on HBOs The Leftovers), is uncanny television. A dystopian series full of death and menace that threads in so much humanity and optimism that you want to be in its precarious world. I was gripped, cheered, and horrified.

To be sure, this is art-house TV and demanding in stretchesnot the next fix for the Squid Game crowd (although I found it much more jolting). The braided timeline gives us the bustling world before the virus hits, starting with a performance of King Lear in Chicago in which its star, played by Gael Garca Bernal, collapses and dies on stage. It also shows us the world two decades later, when nature has overrun civilization and a mysterious (but joyful) troupe called the Traveling Symphony is caravanning around, performing Shakespeare and fending off threats from strangers and a Prophet figure who has gathered a small army of menacing children.

In the Chicago timeline, a freelance writer named Jeevan (played wonderfully by Himesh Patel) finds himself looking after Kirsten (Matilda Lawler), an 8-year-old actress, and taking refuge in a high-rise condo with his brother Frank (Nabhaan Rizwan). These three will ride out the dark early months of the pandemic in a kind of magical wintertime isolation.

Lori Petty as The Conductor.

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HBO Maxs Station Eleven is, Hands Down, the Best New Show of the Year - newsconcerns

A phase 2 trial with the company's chronic-cough candidate hit its primary endpoint. Key Points

Shares of Bellus Health (NASDAQ:BLU), a clinical-stage biotechnology company, are soaring in response to positive clinical-trial data. Investors excited about the company's lead candidate BLU-5937 drove the stock 58.4% higher as of 10:30 a.m. ET on Monday.

Bellus Health's lead candidate is a potential first-in-class P2X3 inhibitor for the treatment of refractory chronic cough (RCC) and eczema-related itching. The biotech stock is up sharply today because 28 days of treatment with BLU-5937 led to a significant improvement to RCC patients' daily cough frequency during the phase 2 Soothe trial. Compared to patients in the placebo group, Soothe participants randomized to receive 50 mg of BLU-5937 twice a day reduced their cough frequency by 34.4%.

Image source: Getty Images.

The P2X3 receptors that regulate an urge to cough are closely related to P2X2/3 receptors that play a role in our ability to taste. BLU-5937 is intended to selectively act on P2X3 receptors in order to preserve patients' ability to taste and appears to work in this regard. None of the patients treated with BLU-5937 reported taste-loss problems.

Bellus Health stock probably would have soared much higher if not for disappointing news from the phase 2 Blueprint trial with eczema patients. Treatment with BLU-5937 didn't lead to a statistically significant itchiness reduction for eczema patients.

Bellus Health's next step will be an end of phase 2 meeting with the Food and Drug Administration (FDA) to discuss the design of an upcoming phase 3 RCC trial with its lead candidate. That means the company could have phase 3 data in hand before the end of 2022.

An estimated 9 million Americans suffer from a chronic cough and there aren't any specific therapies approved to treat the debilitating condition. Following today's phase 2 results, it looks like Bellus could be the first to launch an RCC treatment if a deep-pocketed pharmaceutical company doesn't license marketing rights to BLU-5937 first or buy the entire company at a premium.

This article represents the opinion of the writer, who may disagree with the official recommendation position of a Motley Fool premium advisory service. Were motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.

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Here's Why Bellus Health Is Jumping Higher Today - Motley Fool

It's easy to assume that eczema and bath bombs don't work well together, but that isn't actually the case. The right bath bomb can not only make you feel more relaxed, but it can also help to soothe your skin and prevent your eczema from getting worse. When selecting bath products including bath bombs for eczema-prone skin, It's An Itchy Little World recommends avoiding bath bombs that use preservatives, artificial coloring, and scents as they can cause irritation and trigger an eczema flare-up.

When treating skin that is prone to eczema, it's important to ensure that you are using products that contain the most natural ingredients possible. As per Byrdie, one of the best bath bombs for eczema-prone skin is Eczema Honey Oatmeal Bath Bomb ($8.95) from Eczema Honey Co. This bath bomb helps to calm and soothe eczema thanks to the oatmeal and honey that form a large part of the formula. According to the Eczema Honey Co website, this bath bomb is designed to offer a calming and soothing bath that will give eczema-prone skin all of the moisture and nutrients it craves.

Lushbath bombs also tend to also be suitable for eczema-prone skin, due to being made from all-natural ingredients. One of the most comforting bath bombs is the Black Rose($8.95), which has rose oil to calm the skin and Sicilian lemon oil to uplift it.

More here:
What Is The Best Bath Bomb For People With Eczema? - The List

Cibinqo is a once-daily oral treatment with proven efficacy demonstrated in a large-scale clinical trial program

NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: PFE) today announced that the European Commission (EC) has approved the 100 mg and 200 mg doses of Cibinqo (abrocitinib), an oral, once-daily, Janus kinase 1 (JAK1) inhibitor, for the treatment of moderate-to-severe atopic dermatitis (AD) in adults who are candidates for systemic therapy. Additionally, a 50 mg dose was approved to treat moderate-to-severe AD specifically in patients with moderate and severe renal impairment (kidney failure) or certain patients receiving treatment with inhibitors of cytochrome P450 (CYP) 2C19.

For adults living with moderate-to-severe atopic dermatitis, Cibinqo could help provide relief from the hallmark symptom of intense itch and has demonstrated rapid improvements in skin clearance, extent, and severity of disease, versus placebo, said Dr. Stephan Weidinger, Professor of Dermatology at Christian-Albrechts University Kiel and Vice Head of the Department of Dermatology at the University Hospital Schleswig-Holstein, Kiel, Germany. The approval of Cibinqo in the European Union makes me hopeful for many patients who will have this additional option to help manage the often painful and disruptive symptoms of moderate-to-severe atopic dermatitis.

The approval of Cibinqo was based on the results of five clinical studies of more than 2,800 patients including four Phase 3 studies and an ongoing long-term open label extension study. Cibinqo demonstrated meaningful improvements across measures of symptom relief and disease control versus placebo. In one trial including an active control arm with dupilumab, which evaluated patients on background topical medicated therapy, Cibinqo 200 mg was associated with a greater improvement in itch relief after two weeks than dupilumab. Cibinqo also demonstrated a consistent safety profile across trials, including in a long-term extension study, showing a favorable benefit-risk profile.

There have been few treatment innovations over the last decade for those in the European Union suffering with the daily discomfort, distress, and pain caused by moderate-to-severe atopic dermatitis, said Mike Gladstone, Global President of Pfizer Inflammation & Immunology. The safety and efficacy established through a rigorous clinical trial program, designed to evaluate measures of symptom relief most important to patients, gives us great confidence in the positive impact Cibinqo could have on those living with this debilitating immuno-inflammatory condition.

The most common adverse events reported with Cibinqo in 5% of patients were nausea (15.1%) and headache (7.9%). The most frequent serious adverse reactions were infections (0.3%).

Additional Details on the Cibinqo Clinical Trial Program

Findings from the following five studies in the Cibinqo JAK1 Atopic Dermatitis Efficacy and Safety (JADE) global development program were included in the submission to support this approval. The trials evaluated measures of improvements for AD including the Investigator Global Assessment (IGA), Eczema Area and Severity Index (EASI), and Peak Pruritus Numerical Rating Scale (PP-NRS):

Select findings for Cibinqo 100 mg, 200 mg, and placebo follow. P-value differences versus placebo across endpoints in JADE MONO-1, JADE MONO-2, and JADE COMPARE were *p<0.01 or **p<0.001. Treatment effects in subgroups, such as age or weight, were consistent with the results in the overall study populations.

About Cibinqo (abrocitinib)

Cibinqo is an oral small molecule that selectively inhibits Janus kinase (JAK) 1. Inhibition of JAK1 is thought to modulate multiple cytokines involved in pathophysiology of atopic dermatitis, including interleukin IL-4, IL-13, IL-31, IL-22, and thymic stromal lymphopoietin (TSLP).

Cibinqo received marketing authorization from the UK Medicines and Healthcare products Regulatory Agency (MHRA), the Japanese Ministry of Health, Labour and Welfare (MHLW) and Koreas Ministry of Food and Drug Safety (MFDS) earlier this year.

About Atopic Dermatitis

AD is a chronic inflammatory skin disease characterized by dry skin, intense itching and recurrent relapsing eczematous lesions with a heterogeneous clinical presentation. AD lesions are characterized by erythema (skin turning red or purple depending on normal skin color), induration (hardening)/papulation (formulation of papules), lichenification, oozing/crusting.i,ii,iii

AD affects up to 10% of adults worldwide.iv The prevalence of AD in adults in Europe is approximately 5-10%.v,vi Approximately 1 in 3 adults with AD have moderate-to-severe disease.vii,viii

About Pfizer Inflammation & Immunology

At Pfizer Inflammation & Immunology, we strive to deliver breakthroughs that enable freedom from day-to-day suffering for people living with autoimmune and chronic inflammatory diseases, which can be debilitating, disfiguring and distressing, dramatically affecting what they can do. With a focus on immuno-inflammatory conditions in Rheumatology, Gastroenterology and Medical Dermatology, our current portfolio of approved medicines and investigational molecules spans multiple action and delivery mechanisms, from topicals to small molecules, biologics and biosimilars. The root cause of many immunological diseases is immuno-inflammation, which requires specifically designed agents. Our differentiated R&D approach resulted in one of the broadest pipelines in the industry, where we purposefully match molecules to diseases where we believe they can make the biggest difference. Building on our decades-long commitment and pioneering science, we continue to advance the standard of care for patients living with immuno-inflammatory diseases and are working hand-in-hand with patients, caregivers and the broader healthcare community on healthcare solutions for the many challenges of managing chronic inflammatory diseases, allowing patients to live their best lives.

Pfizer Inc.: Breakthroughs That Change Patients Lives

At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 170 years, we have worked to make a difference for all who rely on us. We routinely post information that may be important to investors on our website at http://www.Pfizer.com. In addition, to learn more, please visit us on http://www.Pfizer.com and follow us on Twitter at @Pfizer and @Pfizer News, LinkedIn, YouTube and like us on Facebook at Facebook.com/Pfizer.

Disclosure Notice

The information contained in this release is as of December 10, 2021. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.

This release contains forward-looking information about Cibinqo (abrocitinib), including its potential benefits and an approval by the European Commission, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for our clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when drug applications may be filed in any other jurisdictions for any potential indication for Cibinqo; whether and when the application for Cibinqo pending with the U.S. Food and Drug Administration may be approved and whether and when any such other applications that may be pending or filed for Cibinqo may be approved by regulatory authorities, which will depend on myriad factors, including making a determination as to whether the product's benefits outweigh its known risks and determination of the product's efficacy and, if approved, whether Cibinqo will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of Cibinqo; uncertainties regarding the commercial or other impact of the results of Janus kinase (JAK) inhibitor studies and data and actions by regulatory authorities based on analysis of such studies and data, which will depend, in part, on benefit-risk assessments and labeling determinations; uncertainties regarding the impact of COVID-19 on our business, operations, and financial results; and competitive developments.

A further description of risks and uncertainties can be found in Pfizers Annual Report on Form 10-K for the fiscal year ended December 31, 2020 and in its subsequent reports on Form 10-Q, including in the sections thereof captioned Risk Factors and Forward-Looking Information and Factors That May Affect Future Results, as well as in its subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission and available at http://www.sec.gov and http://www.pfizer.com.

i Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet. 2020 Aug 1;396(10247):345-360. doi: 10.1016/S0140-6736(20)31286-1. Erratum in: Lancet. 2020 Sep 12;396(10253):758.

ii Wollenberg et al. European Task Force on Atopic Dermatitis/EADV Eczema Task Force. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad Dermatol Venereol. 2020 Dec;34(12):2717-2744.

iii Kaufman BP, Guttman-Yassky E, Alexis AF. Atopic dermatitis in diverse racial and ethnic groups-Variations in epidemiology, genetics, clinical presentation and treatment. Exp Dermatol. 2018 Apr;27(4):340-357.

iv Oszukowska M, Michalak I, Gutfreund K, et al. Role of primary and secondary prevention in atopic dermatitis. Postep Derm Alergol. 2015:32(6):409-420.

v J. Silverberg, A. Wollenberg, A. Egeberg, et al. Worldwide prevalence and severity of Atopic Dermatitis. Poster presented at EADV 2018 Annual Meeting. Paris, France.

vi Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. 2018;73(6):1284-1293. doi:10.1111/all.13401.

vii Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. 2018;73(6):1284-1293. doi:10.1111/all.13401.

viii Mathiesen SM, Thomsen SF. The prevalence of atopic dermatitis in adults: systematic review on population studies. Dermatol Online J. 2019 Aug 15;25(8):13030/qt6nj0x5k0.

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Original post:
European Commission Approves Pfizer's Cibinqo (abrocitinib) for the Treatment of Adults with Moderate-to-Severe Atopic Dermatitis - Pfizer

Eczemais a type ofskin condition that's caused by a combination of immune system activation, genetics and environmental triggers, affecting one in 10 adults in the UK. For many Brits, thewinter weather has worsened eczema symptoms as the cold air dries out, but it turns out those long, hot showers could be making it even more inflamed. Managing eczema during the winter can be tricky, but making these simple adjustments could relieve some of the symptoms.

A recent study by The University of Sheffield has found that the hardness of tap water can affect the inflammation of atopic dermatitis - more commonly known as eczema.

The study tested how washing with different kinds of water affects those suffering with eczema and skin irritation.

One of the key conclusions from the study was that hard water ultimately makes eczema worse.

Calcium, magnesium and other other properties found in hard water were found to be the most drying, pro-aging substances which contribute to inflammation of eczema on the skin by disrupting the skin's natural moisture barrier.

While you cant completely change the hardness of your water, Harvey Water Softeners have shared their top tips to prevent skin irritation and dryness this winter.

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Water quality in the UK differs across the nation with some areas accessing harder water than others.

The South East of England and London are known for particularly high levels of water hardness which can worsen the effects of eczema when showering, bathing, or washing your hands.

Limiting the number of showers you have in a day will expose your skin to the irritating substances in hard water while maintaining natural oil levels in the skin.

Speaking toExpress.co.uk, Harvey Water Softeners said: There is nothing better than jumping in a hot shower after a long day. However, extremely hot showers can dry out your skin, rather than hydrating it.

To avoid stripping the moisture from your cells, limit your warm showers to no more than one 10 minutes a day.

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Natural, thick moisturisers work well to repair damage to the skin's moisture barrier and help manage eczema symptoms.

Replenish moisture by applying lotions or emollients in a humid environment, perhaps after a bath or shower when the skin is fully hydrated.

This will lock much-needed moisture into the skin and should be done at least twice a day.

During the winter, you should use thicker products to supplement lost moisture and pay particular attention to your hands and face - these are key areas which are exposed to the cold winter air and can quickly become dry and damaged.

When suffering with eczema, it is important to keep your skin moisturised and calm with gentle products and fabrics that wont irritate existing flare-ups.

There are a few key points to remember when managing eczema in the winter, including:

Keeping your skin moisturised starts from within, so dont skimp on your water intake through the winter months.

While your body may feel cold outside, drinking plenty of cold water will keep your skin supple and your mind focused.

Herbal tea is a warming alternative to plain water, but you should always keep a jug nearby to remind yourself to keep sipping.

Use a water filter to remove impurities such as micro-plastics and chalky minerals in the process for a more refined drink.

Read more here:
Eczema treatment: Why your water could be making your eczema worse in the winter - Daily Express