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Category Archives: Life Extension

Extension welcomes new family life team member who is serving Southern Illinois area – Annanews

Posted: February 27, 2021 at 3:32 am

Robin Ridgley is the newest member of the University of Illinois Extension family life team.

She is serving Franklin, Jackson, Perry, Randolph, and Williamson counties in Southern Illinois.

Were excited to welcome Robin to the Illinois Extension team. As a family life educator, her work will address important issues that many families face, especially during a global pandemic, Extension county director Lynn Heins said in a news release.

Her program priorities relate to social-emotional wellness, brain health, and family relationships. Much of Robins work aligns with community partners and results in larger impact for our communities.

A native of Benton, and a two-time Southern Illinois University alumna, Ridgley received her bachelors degree in elementary education and a masters degree in education administration.

She has many years of experience teaching in the public school system.

Most recently, she served as a family services school-based counselor and a prevention specialist at Centerstone, a not-for-profit mental health care provider.

Ridgley has also served youth in foster care as a child welfare specialist at Lutheran Social Services of Illinois, a not-for-profit social services agency.

She lives in Creal Springs with her husband, Rick Ridgley. Together, they lead a local support group for those who have experienced, or are experiencing, divorce.

She has three grown children and two grandchildren with whom she enjoys sharing her love of birding and collecting driftwood.

Ridgley said she is excited to connect with local partners and community members as she provides educational programming and resources on healthy living throughout the lifespan.

She is based in the Williamson County office and can be reached at rridgley@illinois.edu or 618-993-3304.

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Extension welcomes new family life team member who is serving Southern Illinois area - Annanews

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Dr. Andrea Pryce Selected as Operations Manager for the Coral Springs Regional Institute of Public Safety Coral Springs Talk – Coral Springs Talk

Posted: at 3:32 am

Dr. Andrea Pryce

By Sharon Aron Baron

The Coral Springs Fire Department has selected a new operations manager for the Coral Springs Regional Institute of Public Safety to elevate and advance its outreach through various future educational programs.

Dr. Andrea Pryce, a doctor of naturopathic medicine, was selected for her experience and vast knowledge of health and is the first woman to lead the fire academy.

I am happy to welcome Dr. Pryce to our team, said Fire Chief Michael McNally. She brings a considerable amount of educational experience to our organization, which provides the opportunity to advance our training and educational programs for students and the fire rescue profession.

Before joining the City of Coral Springs, Dr. Pryce worked at Life Extension Foundation as an oncology health advisor providing integrative oncology information to patients from all over the world. She went on to serve as medical editor of Life Extension Magazine.

Dr. Pryce has served as a faculty member at several different institutions teaching various health science courses and integrative medicine, like botanical medicine, acupuncture, and holistic nutrition.

Later in her career, she became a program director at Everglades University, where she advanced to associate dean of Allied Health, overseeing the undergraduate and graduate health science degrees. She was promoted to dean of academic affairs at the Boca Raton campus of Everglades University in 2019.

She earned her undergraduate degree, bachelor of science in psychology, from the University of Alaska, where she served as an athletic trainer and had her first experiences working with the firefighter profession.

As a physical therapy assistant in a local sports medicine clinic, she assisted firefighters, smoke jumpers, and athletes of all ages resume physical activity.

In 2006, she received her doctorate in naturopathic medicine from Southwest College of Naturopathic Medicine in Tempe, Arizona. She joined the Arizona Advanced Medicine team in Scottsdale, Arizona, before going into private practice, specializing in cancer treatment.

Fire Chief McNally said, Under her leadership, I look forward to seeing the Coral Springs Regional Institute of Public Safety expand educational opportunities offered through the academy. I am confident she will be a great addition to our team.

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Dr. Andrea Pryce Selected as Operations Manager for the Coral Springs Regional Institute of Public Safety Coral Springs Talk - Coral Springs Talk

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When are the Braves giving Freddie Freeman an extension? – 11Alive.com WXIA

Posted: at 3:32 am

Last year, at 30 years of age he had a monster season. He batted .341, had 73 hits, and 13 home runs.

ATLANTA Freddie Freeman has said he wants to be an Atlanta Brave for life, but he needs an extension and fans are wondering when that will come.

Last year, at 30 years of age he had a monster season. He batted .341, had 73 hits, and 13 home runs.

On the daily Locked On Braves podcast, Dylan Short talked about a large item that was expected to happen over the offseason but hasnt yet, signing Freddie Freeman to an extension.

When do we see a Freddie Freeman extension? This is one of those things that we were expecting to see get done this offseason, said Short. Like I have said before, Im sure they have had a talk and the organization said that they would go ahead and make all of the moves that they need to make first then we will do the extension with the money that they have left over. I think that is the most likely thing.

Freddie has said numerous times that he wants to retire in Atlanta and that he doesnt want to go anywhere, said Short. The Braves certainly want to keep him. They dont want to lose Freddie, who has been the Chipper Jones-type replacement and has been the franchise cornerstone for his whole career. And a guy that is playing better baseball now than he has ever played.

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When are the Braves giving Freddie Freeman an extension? - 11Alive.com WXIA

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Shelf Life Extension Ingredients Market Global Trends, Emerging Technologies And Growth Analysis , Forecast To 2028 Express Keeper – Express Keeper

Posted: at 3:32 am

Growing emphasis on the food safety and longer shelf life has played an important role in the development of ingredients that aid in food preservation. These ingredients vary from simple water content to salt or sugar to chemicals like antioxidants and are used to prevent growth of microorganisms, thereby delaying the spoilage process. In terms of origin, food safety and shelf life extension ingredients can be synthetic or natural in nature.

Food preserving ingredients have been an integral part of kitchen aisles in the form of lemon, ginger, vinegar, spices, salt and sugar. Their traditional utilization was replaced by synthetic ingredients with increasing commercialization of the food industry in past decades. However, with the dissemination of knowledge related to harmful effects of synthetic ingredients, currently, the industry is witnessing a prominent shift toward natural ingredients for food safety and shelf life extension.

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Shelf Life Extension Ingredients Market Notable Developments

Shelf Life Extension Ingredients Market Dynamics

Clean-Label Trend Fuels Synthetic to Natural Transition in Food Ingredient Landscape

Naturally sourced ingredients have gained significant traction as consumer preference for natural products continues to surge. In terms of effectiveness, natural preservatives are superior in delivering greater protection and longer shelf life. As they work with equivalent efficiency and are healthful in nature, adoption of naturally sourced ingredients is increasing consistently as compared to the synthetic options.

Natural ingredients such as antimicrobials or antioxidants have additional potential health benefits also. Well aware of the increasing consumer demand for natural food products that are without artificial ingredients, manufacturers in the food ingredient market are introducing bio-based or naturally sourced food safety ingredients.

Frozen Foods Drive Demand for Specialized Food Safety Ingredients

Ranging from salads to sauces or ready meals to rice, a plethora of food products are available in frozen forms. As the demand for fresh and frozen foods increase across the globe, food manufacturers are seeking innovative ways to introduce novel food safety ingredients to extend the shelf life of frozen foods.

Manufacturers in the food safety and shelf life extension ingredient market are introducing ingredients specific to refrigerated products. Along with providing safety, these ingredients are label friendly and help in reducing sodium content while enhancing consumers sensory experience.

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Shelf Life Extension Ingredients Market Regional Outlook

North America presents lucrative opportunities for the Shelf Life Extension Ingredients Market on the back of buoyancy in regions the food and beverage industry and presence of leading F&B companies.

The market is likely to witness increasing opportunities in the developing countries of Asia pacific. These countries are witnessing huge demand for frozen foods, RTD food and beverages and processed food, thereby presenting higher potential for the market in the future.

Shelf Life Extension Ingredients Market Segmentation

The Shelf Life Extension Ingredients Market is segmented into following,

Based on type, Shelf Life Extension Ingredients Market can be segmented in,

Based in function, Shelf Life Extension Ingredients Market can be segmented in,

Based on application, Shelf Life Extension Ingredients Market can be segmented in,

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Shelf Life Extension Ingredients Market Global Trends, Emerging Technologies And Growth Analysis , Forecast To 2028 Express Keeper - Express Keeper

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For Twin Cities power couple and their family, home is an extension of faithful service – Minneapolis Star Tribune

Posted: at 3:32 am

After a natural gas explosion tore through a Minnehaha Academy building in August 2017, claiming the lives of two cherished employees, pathbreaking couple Y. Marc and Alicia Belton joined other officials, parents and community members in a multipronged effort to repair the breach at their children's school.

Quiet and self-effacing, the philanthropists aimed to rebuild the physical structure and help heal the community's jagged spirit.

"Marc and Alicia have been generous with their time, talent and treasure even before the event," said Minnehaha Academy President Donna Harris, who herself was lauded for her heroic leadership during the episode. "They exude warmth and care, with a great heart for service. They've always been people connectors and have hosted many events in their homes."

Their current home, a historic Mediterranean-style house overlooking Minneapolis' Lake of the Isles, is one they moved to almost a decade ago. Even before they took up residence, Alicia, one of the earliest licensed Black female architects in Minnesota history and the incoming 2022 president of the Minnesota chapter of the American Institute of Architects, led a nine-month top-to-bottom update that brought an aesthetic cohesion to the restoration.

All that work was necessary because of the house's long, sometimes complicated history. First owned by the manager and editor of a publication called the Daily Market Record, one Plumleigh Rogers, the 1916 property reflected the aesthetic choices of subsequent occupants over the decades, including former news anchor Paul Magers and Par Ridder, the onetime Pioneer Press publisher who also served briefly in the same capacity at the Star Tribune.

"Every owner did something different, and it wasn't a merged vision," Alicia said. "There was a circular staircase that somebody wanted, but it was overdone. In some places, it was 2 feet wide. Paul Magers put the pool in, but the way it was, you couldn't see it from inside. We opened it up to see the kids."

In their previous place, a Spanish-style house near Lake Harriet, the Beltons regularly entertained family and friends with gatherings marked by joyful music, bonhomie and scrumptious food. They also hosted a summer open house that was the culmination of a golf tournament Marc holds annually as part of the family's extensive philanthropic efforts. That summer function drew an eclectic, diverse mix of people from all walks of life, including from the faith, corporate and arts communities.

When the Beltons thought about moving, they wanted their home to still be a place of welcome. But they also had other reasons, including having "a place where my mother-in-law could stay," Alicia said.

Mildred Belton, a retired administrative assistant now in her 90s, lives independently in suburban New York, where Marc grew up. Belton's late father, York, was a police officer.

The mother-in-law suite is still waiting, Marc said. "If she ever decides to [move in], it's ready."

That area of the house was part of the renovation. So was the kitchen, which was reoriented.

The Beltons put the laundry room upstairs "much more practical," Alicia said. In fact, the upstairs was reduced to the studs, and redone to open up space, reorient space and bring in more light.

And they took out the squished, tight-throated circular staircase in favor of one that now breathes.

The house also reflects a music-minded love story between a New Yorker and a Texan who met in Minnesota. As a teenager, Marc, a bass player, gigged with professional funk bands in nightclubs and had thoughts of a life onstage. But after his brilliant older sister, Monique, got into Harvard, his parents pressed him to focus on his studies.

He did, and matriculated at Dartmouth, then later earned an MBA at the University of Pennsylvania's Wharton School, where he studied marketing.

When he came to General Mills in 1983, Marc intended to stay a couple of years. But in his 32-year career at the global food giant, he made huge strides for the company, and himself. One of his many milestones includes becoming the youngest president of a company division. His success created space for others in the corporate community even as he mentored, and continues to mentor, new talent.

Alicia, who plays piano, moved to the Twin Cities after graduate school at the University of Illinois to take a job at 3M, where she was a project engineer. The daughter of an African American father and Thai mother, she grew up in Galveston, Texas, dreaming of becoming an architect. But she had no nearby role model, only TV dad Mike Brady of "The Brady Bunch."

Now she has her own company, Urban Design Perspectives, and is a more-immediate muse to others.

"Alicia is an even-keel, classy, inspiring role model for me," said Twin Cities architect Demaris Hollingsworth. "I'm not much younger she could be my big sister. But she's so mature, centered and balanced, I feel like a kid around her. And, of course, she's a pioneer in our field."

Marc and Alicia came together "by providence, not coincidence," said longtime family friend Kimberly Price, who served as a senior 3M executive but has become better known as a matchmaker. "They are both smart and beautiful and share so much in common. But the strongest thing about them is their faith. They both believe deeply that to whom much is given, much is required, and they live that quietly."

Price introduced them 25 years ago when Mildred Belton called from New York to ask for help with the search for a spouse for her only son. Two weeks later, Price saw Alicia Grant at the church they both attended, Pilgrim Baptist in St. Paul. Alicia was working with a clutch of kids in the nursery.

"I saw her with those children, and she had an ethereal presence about her," she said. "If she could love up on the little kids, she could love up on the big kid Marc."

She called Alicia on a lunch break to get to know her. That initial chat lasted 45 minutes.

"Sweet as could be," Price said. "I just knew: God made them to be together."

Faith informs nearly everything about the Beltons' life. If their home is beautiful, it's for a bigger purpose. It's in the family's mission statement, which hangs on a wall near the front.

Their home "will be a vehicle for blessing and ministry," it says, and their works will be evidence of their faith to "glorify the Lord."

Ask them about any of their achievements, and they become bashful. They give credit to others with whom they work. Most important, they point to the heavens.

"If anything great happens in our lives, it's because the Lord has done something with us," Marc said. "We serve an audience of one."

While that may be, it doesn't stop folks from admiring their intellect, generosity and spirit.

"Marc brings a different way of thinking to a conversation, one that asks questions I hadn't considered, or frames them in a way that I wouldn't expect, which in turns expands my own thinking," said Joseph Haj, artistic director of the Guthrie Theater, on whose board Marc has served for years. "He is so smart, so capable and so philanthropically and community-minded that he brings much to the table in whatever he does."

Architect Hollingsworth has been to the house and seen the renovation.

"Alicia redesigned it with such high quality," she said. "The way it flows, entertaining in their home is easy because the rooms open up to the patio. But there's this sense of calm and peace about it. And, of course, I remember the food. Very, very good."

The Beltons see a lot of work before them.

There are still only a handful of Black female architects in Minnesota and about 500 nationwide Alicia noted. She intends to do something about that.

The Belton Family Foundation, which someday will pass to children Alexander, 14, and Gabrielle, 11, supports a host of causes, including a village in Sierra Leone. Marc, through the Wisefellows Consulting business he launched after his retirement, formally and informally nurtures a new generation of leaders.

The family also is involved in their church, Sanctuary Covenant.

There are ample causes in the Twin Cities, including at Minnehaha Academy, where Marc is board chair and has led the capital campaign. Alicia also serves on the board of Habitat for Humanity.

Their house is a testament to their good works, Price said. It's a locus and launchpad for "the great things that they're doing."

If they have made their home a warm sanctuary, it is because they desire that others have the same, even those they will never know.

Rohan Preston 612-673-4390

@rohanpreston

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For Twin Cities power couple and their family, home is an extension of faithful service - Minneapolis Star Tribune

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Springfield National Weather Service radar scheduled outage coming, will last about a week – KOLR – OzarksFirst.com

Posted: at 3:32 am

SPRINGFIELD, Mo. Beginning Thursday, February 25, 2021, the radar operated by the NOAA National Weather Service will be down for approximately seven days.

The planned outage is to replace the generator, fuel tanks, and accompanying components.

This update is important to support the radars operation during periods of commercial power outages, specifically when hazardous weather is present.

This generator update is the third major project of the NEXRAD Service Life Extension Program, a series of upgrades and replacements that will keep our nations radars viable into the 2030s.

NOAA National Weather Service, the United States Air Force, and the Federal Aviation Administration are investing about $150 million in the seven-year program. The first project was the installation of the new signal processor and the second project was the transmitter refurbishment. The two remaining projects are the refurbishment of the pedestal and equipment shelters. The Service Life Extension Program will complete in 2023.

During the outage, check data from adjacent radars including: Pleasant Hill/Kansas City (KEAX), St Louis (KLSX), Paducah, KY (KPAH), Memphis, TN (KNQA), Little Rock, AR (KLZK), Fort Smith, AR (KSRX), Tulsa, OK (KINX), Wichita, KS (KICT) and Topeka, KS (KTWX).

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Springfield National Weather Service radar scheduled outage coming, will last about a week - KOLR - OzarksFirst.com

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Global Military Aircraft Modernization and Upgrade and Retrofit Markets to 2024: Incorporation of CNS Systems in aircraft and Emergence of SVAB -…

Posted: at 3:32 am

Dublin, Feb. 25, 2021 (GLOBE NEWSWIRE) -- The "Global Military Aircraft Modernization and Upgrade and Retrofit Market 2020-2024" report has been added to ResearchAndMarkets.com's offering.

The military aircraft modernization and upgrade and retrofit market is poised to grow by $ 2.61 bn during 2020-2024 progressing at a CAGR of 3% during the forecast period.

The market is driven by the incorporation of CNS systems in aircraft and emergence of SVAB.

The reports on military aircraft modernization and upgrade and retrofit market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.

The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The military aircraft modernization and upgrade and retrofit market analysis includes type segment and geographical landscapes.

This study identifies service life extension of military aircraft fleets as one of the prime reasons driving the military aircraft modernization and upgrade and retrofit market growth during the next few years.

The robust vendor analysis is designed to help clients improve their market position, and in line with this, this report provides a detailed analysis of several leading military aircraft modernization and upgrade and retrofit market vendors that include BAE Systems Plc, Elbit Systems Ltd., Honeywell International Inc., Israel Aerospace Industries Ltd., L3Harris Technologies Inc., Lockheed Martin Corp., Northrop Grumman Corp., Raytheon Technologies Corp., Thales Group, and The Boeing Co..

Also, the military aircraft modernization and upgrade and retrofit market analysis report includes information on upcoming trends and challenges that will influence market growth. This is to help companies strategize and leverage on all forthcoming growth opportunities.

Key Topics Covered:

Executive Summary

Market Landscape

Market Sizing

Five Forces Analysis

Market Segmentation by Type

Customer landscape

Geographic Landscape

Vendor Landscape

Vendor Analysis

Appendix

For more information about this report visit https://www.researchandmarkets.com/r/lyfiou

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Global Military Aircraft Modernization and Upgrade and Retrofit Markets to 2024: Incorporation of CNS Systems in aircraft and Emergence of SVAB -...

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CH-53K King Stallion Beats CH-47 Chinook To Become Israel’s Next Heavy Lift Helicopter – The Drive

Posted: at 3:32 am

At the same time, the King Stallion is also significantly more expensive than the Chinook. The Pentagon 2021 Fiscal Year budget request pegged the King Stallion's unit cost at around $125 million. Though the exact configuration of the Chinook variant that Boeing had offered to Israel is unclear, which was reportedly a hybrid of sorts between the MH-47G flown by the U.S. Army's elite 160th Special Operations Aviation Regiment and the Canadian military's CH-147F, the price of a standard new-build CH-47F version is around $42 million.

Lockheed Martin has been touting the fact that the CH-53K can leverage much of the existing infrastructure that the IAF uses to operate and maintain its existing CH-53s as a mitigating factor. The company also says the King Stallion has a similar physical footprint to the Yasurs making it easier to use hangars and other facilities already established for the older helicopters.

"This is a smart aircraft with sensors built-in. Following our commercial helicopter sustainment model, the aircraft can analyze itself," Dan Schultz, President and CEO of Sikorsky, said last year, referring to the artificial intelligence-driven predictive maintenance capabilities of the King Stallion, which are designed to further help reduce maintenance and logistics costs. "Israel has a stark choice: they can go with an aircraft that competed with the CH-53D already, or they can look into the future with the CH-53K."

Israel has been flying CH-53 helicopters since 1969, when it received its first two examples, after having selected the type over the CH-47. These were roughly equivalent to the twin-engine CH-53D Sea Stallions and were also known by Sikorsky's internal company designation S-65C-3. They had a much greater payload capacity than any other helicopter in Israeli service at that time and immediately proved their worth during the War of Attrition with the Palestinians and the country's Arab neighbors. Yasurs were famously critical to the success of an operation that resulted in the capture of Soviet-made P-12 radar from Egypt, a major intelligence coup.

The helicopters have continued to be an important part of Israeli operations since then and are used to perform various specialized missions, including combat search and rescue, special operations forces support, and electronic warfare. They have also received significant upgrades over the years. In the last 25 years or so the remaining fleet has gone through two major upgrade and life extension efforts, bring the helicopters first to a standard known as Yasur 2000 and then to the latest Yasur 2025 configuration.

"In total, the 2025 upgrade encompasses around 20 new systems, with these also including advanced electronic warfare equipment, satellite communications, an altitude hold and hovering stabilization system, and a laser obstacle ranging and display system," according to a story from Flight International in 2009. "Sikorsky has also supplied replacement main gearboxes, with the type's original equipment having been monitored closely for cracks over recent years."

Unfortunately, the helicopters are becoming more difficult to operate and maintain, something that has become increasingly apparent in recent years. In November 2019, a Yasur made an emergency landing after a fire broke out on board. Everyone on the helicopter escaped unscathed, but the CH-53 was destroyed. The incident led to the grounding of the entire fleet. In January 2020, two weeks after that grounding was lifted, another Yasur had to make an emergency landing due to a technical issue. Three months later, yet another one of the helicopters suffered a technical fault that forced it to land.

The acquisition now of new CH-53Ks will ensure that the Israelis continue to have access to this kind of valuable heavy-lift helicopter capability for decades to come.

Contact the author: joe@thedrive.com

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North Sea Veslefrikk field to cease operations – Offshore Oil and Gas Magazine

Posted: at 3:32 am

The Veslefrikk field in the North Sea.

(Photo: yvind Hagen / courtesy Equinor)

Offshore staff

STAVANGER, Norway Equinor and its partners will end production from the Veslefrikk field in the Norwegian Sea in spring 2022.

Operations started in 1989 through Norways first floating production platform, and the facilities have since produced over 400 MMboe.

Investments to date total around NOK20 billion ($2.36 billion), and the fields productive life has been extended several times: it was originally expected to cease production in 2009.

Veslefrikk B is a semisubmersible production platform is connected to the fixed Veslefrikk A wellhead platform (converted from the drilling rig West Vision).

In 2002 the field also began processing from the Huldra field (since decommissioned) with a shared control room and crew.

Equinor operates Veslefrikk from its center in Sandsli outside Bergen, which also oversees operations at the Oseberg area.

In the fall of 2020, the company submitted its decommissioning plan to the Norwegian authorities. Its new Field Life Extension (FLX) business area has responsibility for implementing decommissioning projects on the Norwegian continental shelf.

Before Veslefrikk B can be towed to shore for dismantling in the fall of 2022, its topside systems must be shut down and cleaned, and oil and gas export pipelines cleaned and disconnected.

Over the years 74 wells have been drilled on the field. Archer started plugging wells from Veslefrikk B last month, with Baker and Ardyne supplying most other drilling and well services: a total of 24 wells will be plugged.

Veslefrikk A should be removed in 2025/26.

Before mid-2021 Equinor expects to award contracts for removal and dismantling of Veslefrikk A; dismantling and recycling of Veslefrikk B; and work on the seafloor associated with export pipeline cleaning and disconnection.

Further contracts will follow for the planning, management, and implementation of the towing of Veslefrikk B to shore.

Other partners in the license are Petoro, Repsol Norge, and Wintershall Dea Norge.

02/22/2021

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Actinidia eriantha Polysaccharide and PD1-Antibody Combination Therapy | OTT – Dove Medical Press

Posted: at 3:32 am

Jinxia Li,1 Yiping Wang,2 Weiyang Jin,3 Li Shen4

1College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Peoples Republic of China; 2Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, Peoples Republic of China; 3School of Life and Environmental Science, Hangzhou Normal University, Hangzhou, 311121, Peoples Republic of China; 4Institute of Basic Theory of TCM, China Academy of Chinese Medical Sciences, Beijing, 100700, Peoples Republic of China

Correspondence: Li ShenInstitute of Basic Theory of TCM, China Academy of Chinese Medical Sciences, Beijing, 100700, Peoples Republic of ChinaTel +86-158-5825-6870Email shenli1116@126.com

Objective: To observe the efficacy of Actinidia eriantha polysaccharide (AEPS) combined with PD1 antibody therapy in colorectal cancerxenograft mice.Methods: CT26 cells were inoculated into 80 C57BL/6 mice to establish the colorectal cancer xenograftmouse model. Mice were divided evenly into a model group, AEPS group, anti-PD1 group, and combined group. AEPS 5mL/kgday was given orally and 10 mg/kg anti-PD1 injected intravenously for 28 days. Tumor growth and mouse survival were observed. Tumor-cell proliferation and metastasis markers Ki67, N-cadherin, KLF4, and Oct4 were detected with immunochemistry and Western blotting, T-cell infiltration in spleens and tumors was detected with MTT and flow cytometry. IFN and TNF were detected with ELISA.Results: Tumor growth was significantly retarded and survival prolonged in the AEPS, anti-PD1, and combined groups. Ki67 expression decreased in the anti-PD1 and combined groups, and N-cadherin, KLF4, and Oct4 expression decreased in the AEPS and combined groups. IFN and TNF levels, T-cell infiltration in spleen, and tumor all increased distinctively in the AEPS and combined groups. The combined group showed better antitumor effects and life-extension effect than the other two groups.Conclusion: AEPS and PD1 antibody-combination therapy can suppresses tumor growth and prolong survival of colorectal cancerxenograft mice by regulating immunofunction, and the combined therapy showed better therapeutic efficacy than the single treatment.

Keywords: colorectal cancer, PD1 antibody, Actinidia eriantha polysaccharide, combined therapy

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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