Category Archives: Life Extension

The BDN Opinion section operates independently and does not set newsroom policies or contribute to reporting or editing articles elsewhere in the newspaper or onbangordailynews.com.

Luke Muggy is an operations researcher, Catherine Cohen is a nurse and a health services policy researcher, and Kristie Gore is a senior behavioral scientist at the nonprofit, nonpartisan Rand Corp.

When President Joe Biden recently presented Congress, and Americans, with his vision for an Advanced Research Projects Agency for Health (ARPA-H), the acronym may have sounded familiar. It should have.

The new health agency would be modeled on the Defense Advanced Research Projects Agency, known as DARPA, a Department of Defense research and development agency. DARPA is responsible for such life-altering technological advancements as the computer mouse and packet-switching the foundation for todays internet (and conceived in partnership with the Rand Corp., where we work).

The purpose of ARPA-H would be to pursue groundbreaking research to develop cures for diseases such as Alzheimers, cancer and diabetes. The potential benefits are enormouslife extension, economic prosperity, national security but so are the potential challenges to its success.

The federal governments role in scientific advancement is not new or unusual. The National Science Foundation and National Institutes of Health have been funding research for decades. But the emphasis on transformative innovations is new.

Biden is now asking for $6.5 billion to launch his health agency, a relatively modest figure when compared with NIHs annual budget of about $41.7 billion.

If successfully funded, ARPA-H and ARPA-E, a new $300-million-per-year research agency focusing on energy, will be the first federal advanced research agencies created since 1958.

It is unclear how long it will take to establish ARPA-H, how it will be structured and to which government authority it will answer. DARPA was formed within a year of the Soviet Union launching Sputnik in 1957, and it was placed within the Defense Department. The parallel move would be to situate ARPA-H within the Department of Health and Human Services. While it might be tempting to place ARPA-H within the NIH, there is some concern that it would be hard to distinguish the purpose of ARPA-H from other high-risk, high-reward initiatives that encourage innovation.

With so many potential research avenues to pursue, ARPA-H could benefit from a clear strategic vision and method for identifying projects that hold the most promise for achieving that vision. Its portfolio of research activities could be developed through a process similar to that used by DARPA, which depends on approximately 100 program managers to develop proposals and to select highly innovative projects for funding.

That would be far more expeditious than the process at NIH, which relies on the broader scientific community to rigorously peer-review proposals over the course of several months. Moreover, NIH proposals require substantial background research, clearly specified hypotheses and preliminary data all things that could stifle innovation at ARPA-H.

Some of the policies that encourage innovation at DARPA may be difficult for ARPA-H to emulate. For instance, DARPA limits tenure for researchers to a maximum of four to five years, to impress a sense of urgency upon them. ARPA-H may need to follow a timeline akin to whats typical in biomedical research, where taking a decade to reach a major breakthrough is common. Any tenure limitations should take this into account.

DARPA also maintains an extremely high tolerance for failure. The modest budgets of the NIH, combined with an enormous pool of applicants, force these institutions to bet on low-risk research that guarantees incremental progress. ARPA-H could take a different approach than NIH by accepting a much higher tolerance for failure, so that researchers are not discouraged from dreaming big.

The scientific methods behind the products of ARPA-H might gain public trust if the agency made a point of being transparent and accessible. Consider how the rapid development of the COVID-19 vaccine was met with incredulity and suspicion, slowing progress toward herd immunity. An investment in ARPA-H could accelerate the time it takes to get innovative ideas from bench to bedside, but it could benefit from informing the public about incremental advancements in a way that is easy to understand.

The presidents vision for ARPA-H could help get more medical treatments to market sooner. Building on lessons from DARPA and NIH, the proposed health agency has the potential to pursue the kind of high-risk research that can lead to high-reward results.

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Joe Biden's proposed health agency would emphasize innovation - Bangor Daily News

If writing for CelebrityNetWorth has taught me anything, it's that there are endless ways to make a billion dollars. You could become a billionaire through a more traditional route like the worlds of finance, tech startups and real estate. You could earn billions as a circus clown. You could earn billions through cryptocurrency. There's probably even at least one person in the world who made a billion dollars from dogecoin.

Crazier still, you could earn your billionaire status thanks to a fateful hallucinogenic trip on magic mushrooms

Johannes Simon/Getty Images

Christian Angermayer isn't a familiar name on Wall Street. He is a 42-year-old German investor who spent most of his life totally abstaining from all drugs and alcohol. His lifelong abstinence streak ended in 2015 after a very fateful dinner party.

In 2015, Christian was a guest at a dinner party seated next to a neuroscientist. The two struck up a conversation about the relative harms and benefits produced by various drugs.

The neuroscientist followed up with a research paper that ranked 20 drugs in order of harmfulness to users.

FYI, alcohol ranked #1 as in it causes the MOST harm to individuals and society at large.

Angermayer was stunned to see that psilocybin aka magic mushrooms ranked at the bottom of the list as in the least harmful. The report claimed that magic mushrooms were a highly effective treatment for severe depression.

The report inspired Christian to break his lifelong abstinence and experiment with mushrooms while on a vacation in the Caribbean, where the substance is legal.

Christian has since described that first experience with magic mushrooms as "life-changing." In fact, he has said it was the most meaningful thing he'd ever done in his whole life.

The trip inspired a moment of profound insight. When he came out of the fog, he claimed to finally understand Bitcoin.

The experience and epiphany inspired him to radically reorganize his investment portfolio. He soon went on to make major investments in psychedelics, weed, space travel, cryptocurrency, life extension and the film industry. It's an odd portfolio for the odd times we live in.

In 2016, Angermayer tried mushrooms again and had another profound, life-changing experience. He got the idea to commercialize psychedelics. To find companies he called up billionaire former Goldman Sachs executive Mike Novogratz. Novogratz told him he knew of a couple, George Goldsmith and Ekaterina Malievskaia, who were trying to start a mushroom business and needed backers.

That startup is Compass Pathways Plc., a pharmaceutical company developing a magic mushroom-based treatment for depression. Angermeyer and Novogratz both made angel investments into Compass.

Today Angermayer's stake in Compass Pathways is worth $2 billion.

Angermayer's strategy is simple. He invests in the things he's passionate about.

To date he has invested in AbCellera Biologics, which had a part in developing an antibody-drug for Covid-19. He founded Atai Life Sciences, a psychedelics-biotech startup that has backing from Peter Thiel.

Angermayer has made a fortune on his investments over the past 14 months. His Apeiron Investment Group has been the main investor in seven companies that have made their IPO in the last year. Those IPOs raised more than $1 billion combined. Ten more companies he's invested in plan to go public in 2021.

As of this writing, Christian's investment fund Apeiron manages more than $2.5 billion in assets. Roughly 50% of the fund's assets are Angermayer's personal funds.

In other words, Christian's net worth is around $1.25 billion. A billion dollar fortune inspired by a magic mushroom hallucination. What a trip!

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How Taking Magic Mushrooms Led To A Billion Dollar Fortune - Celebrity Net Worth

A nation with a past deeply rooted in the religious worldview, Russians happened to get to space first in 1961 and Yuri Gagarin, famously, didnt see God. But, religion and astronautics have always been close.

The idea of space travel was first created by a Russian Orthodox philosopher that was born with the last name Gagarin.

Portrait of Nikolay Fyodorov by Leonid Pasternak

A school teacher and librarian, Nikolay Fyodorov (1829-1903) opposed the idea of property of books and ideas and never published anything during his lifetime. He refused to be photographed and to sit for portraits and two of his depictions had to be made secretly. Most of his teachings he conveyed orally to his disciples and friends. The founder of the Russian cosmism philosophy, Nikolay was a bastard son of Prince Pavel Gagarin (1789-1872). It is considered a coincidence that the first man in space also bore this surname. During his life, Nikolay was known under the surname of his godfather, Fyodorov.

READ MORE: Was Gagarin REALLY the first man in space?

For the latter part of his life, Fyodorov worked in Moscow as a librarian in the Rumyantsev Museum library, which is now the Russian State Library. There, he befriended a lot of intellectuals of his time, including Leo Tolstoy and Konstantin Tsiolkovsky, the pioneer of Russian astronautics and rocket science.

Tsiolkovsky's description and drawing of a spaceship greenhouse

Fyodorov was a strict observant of Russian Orthodox Christianity, but, at the same time, a natural philosopher. His main idea was radical life extension by means of science. He believed that spiritual and scientific development of humanity would lead to the fulfilment of the ultimate Christian idea: the banishment of death and revival of the dead, using the idea of cloning. Fyodorov also believed that space exploration was necessary, because the resources of the Earth are depletable. Later, his followers, who called themselves biocosmists, propagated the idea of immediate development of space communications. The teachings of Fyodorov were taken into account also by Sergey Korolev, the creator of the first Russian space flight.

Konstantin Tsiolkovsky. From the "Space exploration" series. Palekh Russian traditional miniature painting.

Konstantin Tsiolkovsky has the full right to be named the Russian Da Vinci, because, apart from his scientific studies, he was deeply involved in mysticism. Tsiolkovsky stated that he developed the theory of rocketry only as a supplement to philosophical research on the subject.

From the age of 35, he lived and worked in Kaluga, the town that became the center of the Russian theosophical movement. Deaf from an early age due to scarlet fever he suffered as a child, he was very introspective and, for most of his life, continued self-studying. He was at the same time an affectionate and lively soul and claimed to have experienced revealing visions twice in his life.

Konstantin Tsiolkovsky with models of his zeppelin

READ MORE: 5 of the most important discoveries by the 'Russian Leonardo da Vinci'

His own philosophy consisted of theism, pantheism and esoterics. He believed in the existence of God, but didnt associate him with Christ. Developing a theory of space exploration, parallel with Fyodorovs ideas, Tsiolkovsky famously said: The earth is the cradle of humanity, but you cant live in a cradle forever!

Sergey Korolev sends Yuri Gagrin to space. From the "Space exploration" series. Palekh Russian traditional miniature painting.

Sergey Korolev (1907-1966), the leading rocket engineer and creator of Yuri Gagarins space flight, studied the works of both Nikolay Fyodorov and Konstantin Tsiolkovsky. Their findings and ideas inspired Korolevs idea to create a rocket-powered aircraft. It is still debated whether Korolev was religious himself, but he was certainly superstitious. It is known that Korolev didnt put any launches on Mondays and didnt tolerate women on the launch pad but Russian cosmonauts have had a lot of other superstitions, as well.

The 12th century Ladder of Divine Ascent icon (Saint Catherine's Monastery, Sinai Peninsula, Egypt) showing monks, led by John Climacus, ascending the ladder to Jesus, at the top right.

What is really remarkable about the first space flight Korolev managed is the amount of coincidences in its numerology. First of all, April 12, the day that Gagarin went into space, in the Russian Orthodox church calendar falls on the feast of St. John Climacus (John of the Ladder), the author of The Ladder of Divine Ascent, a monastic text that describes how to raise ones body and soul to God through monastic obedience. The main metaphor used by St. John is Jacobs Ladder to Heaven (Genesis, chapter 28). This observation is debated to the present day, with certain Orthodox clerics defending it.

Another coincidence is the total flight time. No doubt it was thoroughly calculated for example, the next space flight, August 6-7 1961, performed by German Titov on Vostok-2, lasted for exactly 1 day, 1 hour, 11 minutes. Yuri Gagarin on April 12, 1961, famously orbited the Earth in 108 minutes, the number 108 being considered sacred in Hinduism and Buddhism. In these Eastern religions, 108 is a lucky number associated with divine harmony, completion and success.

Consecration of the 'Soyuz-FG' launch vehicle with the Soyuz TMA-20M transport manned spacecraft at the launch complex of the Baikonur cosmodrome.

It is widely known that in 1964, three years after the flight, Yuri Gagarin went to Trinity Lavra of St. Sergius only for sightseeing. But in the Soviet atheist times, even this led to certain problems and inquiries by Party officials. Later, in post-Soviet times, religious beliefs became a private matter again. And, it turns out, many contemporary Russian cosmonauts are religious.

However, the same can be said about American astronauts. For example, in 1963, Gordon Cooper spoke and recorded a Thanksgiving prayer during his flight. On Christmas Eve, December 24, 1968, the crew of Apollo 8 read from the Book of Genesis as they orbited the Moon and there are other examples.

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How are religion and Russian space science connected? - Russia Beyond the Headlines

Nigeria signed an accord with some of the worlds largest oil companies that could unlock billions of dollars of investment in an offshore oil field.

The Nigerian National Petroleum Corp. concluded agreements on Tuesday with Royal Dutch Shell Plc, Exxon Mobil Corp., Total SA and Eni SpA to create a new production sharing contract for Oil Mining Lease 118, the company said on Twitter. The permit includes Bonga, a deep-water oil field that pumped about 90,000 barrels a day in February.

The partners have so far deferred taking a final investment decision on the Bonga South West project, which could add 150,000 barrels per day to Nigerias output and bring OML 118s total daily capacity to around 350,000 barrels. One of Shells Nigerian subsidiaries operates the block.

Bonga South West could become Nigeria's biggest deepwater field, with others in decline

Source: Tanker tracking data monitored by Bloomberg

The agreement is a watershed for deep-water oil exploration in Nigeria and settles long-running disputes between the Nigerian state and the international oil companies, NNPC said. It could clear the way for more than $10 billion of investment, according to the company.

Through these agreements, stakeholders will have clear and stable set of terms incentivizing further development of the OML 118 block and opening further opportunities in the prolific Nigerian deep water oil and gas industry, a Shell spokesman said by email.

In a separate investor presentation on Tuesday, Shell said it has three projects related to Bonga that are in development but havent yet been given the green light -- Bonga South West, North Tranche 1 and Main Life Extension and Upgrade.

With assistance by Laura Hurst, and Julian Lee

Before it's here, it's on the Bloomberg Terminal.

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Nigeria in Accord With Oil Majors That May Unlock New Investment - Bloomberg

In the 1950s, students at Theodore Roosevelt Junior High on Guy Park Avenue in Amsterdam put out a weekly newspaper, The Broadcaster. Faculty advisers were English teacher Minnie Anderson and John Carnwright, who taught printing.

Maureen Hanna of Amsterdam provided two editions from 1957.The paper earned a first-place rating that year in the Columbia Scholastic Press Association contest for junior highs with enrollments between 700 and 1,200.

The 1957 co-editors were Christopher Turner and Peter Betz.Betz is retired as Fulton County historian.The lead story in March was the student production of The Silver Skates starring Phillip Bracchi as Hans Brinker.Kathy Dersham got a good review for her vivacious and lovable portrayal of Gretel Brinker.Imogene Fitzgibbons was faculty director.

Principal Fritz Heil had dropped in on an eighth-grade English class to see how students were doing with this question: What is grammar?One student told Heil, Grammar is the study of the language that a person speaks.Heil was chagrined that some students spelled the word gramer or grammer.

The Broadcaster reported, It may be that your principal will be dropping in on an algebra class, a science class or a social studies class to try a similar experiment on you.

There was a story headlined, Lollipops make school day a thing of joy forever.All the students and teacher Elizabeth Sherlock were licking lollipops in her social studies class.

Sherlock had told students that if they wanted to chew gum or eat candy, they would have to bring enough for the class.Students David Reid, Douglas Doesburg and Dave Wieszchowski took her up on the offer.

The Broadcaster reported, As for Mrs. Sherlock, this was the first time she had ever had to eat her own words.

On the sports page, 8DG won the basketball title over 8BR.Homerooms were named with two letters from the last names of their teachers.Harrison Wood led the winning team with 11 points.

A Broadcaster from March 1958 had a story reporting that Charles Maines, Robert Wszolek and Carmen Merando in Fred Martuscellos metal shop were making jewelry.

A review of teenage jargon defined muttnik as a hot dog and reported a coffee pot was the life of the party.

I was a seventh-grader that year and turned in an essay on citizenship, Being obedient to someone in authority is an important part of being a good citizen.

Seventh-grader Thomas Urbelis, who went on to be a high school basketball star and later an attorney, had received a letter from Gov. Averill Harriman.Harriman had heard about Urbeliss interest in New York state history and sent him information on how 1959 would be New Yorks Year of History.

One of my pleasant junior high memories is coming up with the slogan for my eighth-grade homeroom.We were 8CW in honor of our homeroom teacher, Marion Carnwright, who taught art.Her husband, John, taught the print shop.My winning slogan was that we were 8 Can Win.

The junior high was built in 1924 on Guy Park Avenue east of Wall Street and the old high school behind it was annexed to the building. The high school dated from 1904 and was replaced by the Wilbur H. Lynch High School off Bunn Street extension in the 1930s.Lynch today is the middle school.

Attorney Douglas Landon wrote, My class completed eighth grade at Roosevelt in June of 1977, at which time the school closed. I believe it was razed later that year.The site of the school is now the Theodore Roosevelt Apartments.

Categories: News

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Cudmore: Junior High paper gives glimpse of 1950s life - The Daily Gazette

Construction on the Agnes Street extensionwhich will provide east to west connectivity south of Texas 71could begin in summer 2022, Bastrop City Manager Paul Hofmann said Tuesday.

The city's proposed timeline was announced less than a week after the Texas General Land Office awarded Bastrop $4.2 million to fund thestreet extension.

The GLO approvedmore than $28 millionto improve flood mitigation infrastructure in Bastrop, Elgin and Smithville, the state agency announced on May 21. The GLO approved theAgnes Street extension funding in an effort to help first responders reach rapidly-developing areas in southwest Bastrop.

During Tuesdays Bastrop City Council meeting,Hofmann said the city is estimating it will take 10 months to design the project, before construction canbegin

The project will extend Agnes Street from Sterling Boulevard to Texas 304,and construction will take aboutone year to complete.

Part of what Im doing here, I guess, is managing expectations, Hofmann told the council. We got the grant, we dont have a design project yet and it will take several months for us to get that done.

According to the GLO'sMay 21 funding announcement, the project will include acquiring two partial tracts of vacant land and constructing a two-lane asphalt pavement section with a concrete curb and gutter from Home Depot Way to the existing Agnes Street.

Upon completion of the roadway, emergency response time will be dramatically improved, Mayor Connie Schroeder said in last weeks funding announcement. Multimodal mobility for the community and promotion of economic development are additional benefits.

Texas 71,which runs east to west through Bastrop, is designated as a major hurricane evacuation route and as an evacuation route for other flood-related events in Central Texas. Therefore, the Agnes Street extension will provide another east to west connector and help reduce emergency response times during disaster.

Traffic on Texas 71 during evacuation events limits the ability of first responders to provide service south of the highway and west of the Colorado River due to a lack of alternate east and west connector roads, according to the GLO.

Many of the areas hit hardest by natural disasters have never had access to funding for critical infrastructure projects to mitigate flooding and protect residents, Land Commissioner George P. Bush said in a statement May 21. The historic funding were announcing today will go directly to projects that will help fortify Texas homes, businesses and critical infrastructure against future disasters for generations.

Hofmann said that in July, the city expects to receive a contract between it and the GLO for review and approval. At the same time, the city will be working with Kimley-Horn a planning, engineering and design consulting firm to define the scope of work for the project.

Once the city receives this contract, Hofmann said it will undergo legal review and consultant review. Hofmann said the citys consultant for this group of grant applications is The Langford Group.

We will bring that contract to council just as soon as we can, Hofmann said.

Hofmann said Kimley-Horn, which has more than 80 offices across the country including two in Austin, was previously selected by the City Council to work on the Agnes Street project after a competitive process.

Hofmann estimated it would take 10 months to design the project before soliciting bids to construct the extensionand beginthe road work.

He said the design and land acquisition process will begin this summer.

Hofmann also saidAssistant City Manager Trey Job has secured written commitments from property owners to dedicate right of ways for theproject, but a more formal right-of-way conveyance will still need to be executed.

Schroeder, who told the council she was informed of the funding approval on May 19 ahead of the GLO's May 21 announcement, said the city didnt get a grant for the Agnes Street extension project the last time it tried to secure one.

"Imjust thrilled we got the grant for it, Schroeder said Tuesday. Its just awesome to see Bastrop County represented and to see federal dollars going to protect the life, health, safety, drainage protection. Just so thrilled that Bastrop County did so well.

The U.S. Department of Housing and Urban Development has made more than $2.3 billion in disaster relief funding availableforTexas communities affected by Hurricane Harvey and other severe flooding incidents in 2015 and 2016.

The first round of funding, from which Bastrop's street extension project was funded,saw $1 billion awarded for infrastructure projects designed to mitigate damage from future disasters.

Continued here:

Bastrop's Agnes Street extension project expected to break ground in summer 2022 - Austin American-Statesman

When broadband internet recently arrived at the University of Idahos Sandpoint Organic Agriculture Center, Kyle Nagy said the technology became an instant game-changer on expanding distance education opportunities.

Before, when it was windy or there would be thick cloud cover, wed lose the internet sporadically throughout the day, said Nagy, the centers superintendent and orchard operations manager said.

When the College of Agricultural and Life Sciences center near the base of Schweitzer Mountain hosted the Heritage Orchard Conference before the pandemic, perhaps 100 people attended the in-person event.

Now, thanks to broadband installed last winter, more than 1,200 researchers, gardeners and orchardists from nearly all 50 states and 18 countries were enrolled in the webinars last spring.

We reached out to a much larger crowd, Nagy said. No doubt, the broadband and having the bandwidth to reach that many people has been a game-changer.

An Idaho Department of Commerce Rural Broadband grant of $410,000 funded the service, which provides public-accessible wireless internet to the center as well as Extension centers in Boundary, Bonner and Kootenai counties.

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Technology Investments a 'Game-Changer' - University of Idaho

The Market Insights Reports has added a new statistical data to its repository titled as, Global Antioxidant Supplement Market. It provides the industry overview with market growth analysis with a historical & futuristic perspective for the following parameters; cost, revenue, demands, and supply data (as applicable). Furthermore, the report also sheds light on recent developments and technological platforms, in addition to distinctive tools, and methodologies that will help to propel the performance of industries. The report provides pre COVID-19 historic data, the impact of the COVID-19, and also forecasts its recovery post-COVID-19

The Global Antioxidant Supplement Market is expected to grow at a CAGR of about 4.61% during the forecast period of 2021-2026.

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In this report we analyse the major drivers and challenges for this market with an emphasis on macroeconomic trends in each region. We also provide our readers with insights into how these factors are affecting both regional markets and individual companies within the Commercial industry.

Top Companies in the Antioxidant Supplement Market- NOW, Vibrant Health, AST R-ALA, GNC, Jarrow Formulas, Life Extension, and other.

This report segments the Global Antioxidant Supplement Market on the basis of Types are:

Medical Grade

Food Grade

On the basis of Application, the Global Antioxidant Supplement Market is segmented into:

Medical

Food

Cosmetics

Investigator Observers Strong Growth in Specific Regions:

-North America (the United States, Canada, and Mexico)

-Europe (Germany, France, UK, Russia, and Italy)

-Asia-Pacific (China, Japan, Korea, India, and Southeast Asia)

-South America (Brazil, Argentina, etc.)

-Middle East & Africa (Saudi Arabia, Egypt, Nigeria, and South Africa)

Full Browse the report description and TOC:

https://www.marketinsightsreports.com/reports/04192817040/global-antioxidant-supplement-market-2021-by-manufacturers-regions-type-and-application-forecast-to-2026?mode=126

This Antioxidant Supplement Market report addresses:

The Market size from 2016-2021

Expected market growth until 2026

Forecast of how market drivers, restraints, and future opportunities will affect

Segment and regions that will drive or lead the market growth and why

Comprehensive mapping of the competitive landscape

In-depth analysis of key sustainability strategies adopted by market place

Major Points Covered in Table of Contents:

Overview of Antioxidant Supplement Market Global Market Status and Forecast by Regions Global Market Status and Forecast by Types Global Market Status and Forecast by Downstream Industry Market Driving Factor Analysis Market Competition Status by Major Manufacturers Major Manufacturers Introduction and Market Data Upstream and Downstream Market Analysis Cost and Gross Margin Analysis Marketing Status Analysis Market Report Conclusion Research Methodology and Reference

Finally, the Antioxidant Supplement Market report is the believable source for gaining the market research that will exponentially accelerate your business. The report gives the principle locale, economic situations with the item value, benefit, limit, generation, supply, request, and market development rate and figure, and so on. Antioxidant Supplement Industry report additionally Presents a new task SWOT examination, speculation attainability investigation, and venture return investigation

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MarketInsightsReports provides syndicated market research on industry verticals including Healthcare, Information, and Communication Technology (ICT), Technology and Media, Chemicals, Materials, Energy, Heavy Industry, etc. MarketInsightsReports provides global and regional market intelligence coverage, a 360-degree market view which includes statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations.

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Antioxidant Supplement Market Dynamic, Demand Analysis, Statistics, Trends and Opportunities to 2026|NOW, Vibrant Health, AST R-ALA, GNC, Jarrow...

MONROVIA, Calif.--(BUSINESS WIRE)--Xencor, Inc. (NASDAQ: XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted an emergency use authorization (EUA) for sotrovimab (previously VIR-7831), an XmAb-engineered antibody developed by Vir Biotechnology, Inc. (Vir) and GlaxoSmithKline plc (GSK). Sotrovimab has not been approved, but has been authorized for emergency use by the FDA under an EUA, to treat mild-to-moderate COVID-19 in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death. Xencor has provided Vir non-exclusive licenses to XmAb Fc technologies, including Xtend, designed to enhance the half-life of novel antibodies being investigated as potential treatments for patients with COVID-19.

"We are proud that Xtend technology was integrated into sotrovimab for the purpose of reducing the dose administered and potentially enhancing its lung tissue bioavailability and are grateful to Vir and GSK for advancing this important medicine. Xtend has demonstrated, in multiple antibodies and through numerous human clinical trials, the ability to extend antibody drug half-life and reduce dosing frequency in patients, an important feature in anti-viral therapy for pandemic use," said Bassil Dahiyat, Ph.D., president and chief executive officer at Xencor. "Our partnership with Vir exemplifies our commitment to enabling the broad use of XmAb Fc technologies and to rapidly developing potential treatments for COVID-19 and other serious infectious diseases. Though the vaccine rollout is underway, antibody treatments remain an important therapeutic measure to reduce the number of hospitalizations and deaths due to COVID-19."

Vir and GSK are evaluating sotrovimab in an extensive ongoing clinical development program. In March 2021, the partners submitted an EUA application to the FDA based on an interim analysis of efficacy and safety data from the Phase 3 COMET-ICE (COVID-19 Monoclonal antibody Efficacy Trial - Intent to Care Early) trial, which demonstrated an 85% reduction in hospitalization for more than 24 hours or death in high-risk adults receiving sotrovimab compared to placebo, the primary endpoint of the trial.

The emergency use of sotrovimab is only authorized for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of drugs and biological products during the COVID-19 pandemic under Section 564(b)(1) of the Federal Food, Drug, and Cosmetic Act, 21 U.S.C. 360bbb-3(b)(1), unless the declaration is terminated or authorization revoked sooner.

License Agreement with Vir Biotechnology, Inc.

Xencor previously entered into a technology license agreement with Vir Biotechnology, Inc., pursuant to which Vir has non-exclusive access to multiple Xencor Fc technologies, including Xtend Fc technology, designed to extend the half-life of novel antibodies that Vir is investigating as potential treatments for patients with COVID-19. Under the terms of the agreement, Vir is solely responsible for the activities and costs related to research, development, regulatory and commercial activities for their COVID-19 drug candidates, and Xencor is eligible to receive royalties on net sales in the mid-single digit percent range.

Vir is also developing and commercializing antibodies with Xencor's Fc technologies as potential treatments for patients with influenza and hepatitis B virus infection. Vir is solely responsible for the activities and costs related to research, development, regulatory and commercial activities for these additional candidates, and Xencor is eligible to receive development, regulatory and sales-based milestone payments, as well as royalties on net sales in the low- to mid-single digit percent range.

About Xtend XmAb Fc Technology

Xencors Xtend XmAb Fc domains have been shown to increase circulating half-life by increasing binding affinity to the receptor FcRn. FcRn is present inside lysosomes in endothelial cells lining the blood vessels and functions to rescue antibodies from the degradation that makes most proteins short-lived in circulation. Half-life extension can be exploited to potentially improve therapeutic antibody performance in several ways, such as increasing dosing interval or decreasing drug quantities at the same dosing interval compared to a parent antibody. Xtend technology is currently in multiple clinical-stage programs and one approved therapy, Alexions Ultomiris (ravulizumab-cwvz).

About Cytotoxic XmAb Fc Technology

Xencors Cytotoxic XmAb Fc domain is designed to improve the immune systems elimination of tumor and other pathologic cells by antibody-dependent cellular cytotoxicity (ADCC). The Cytotoxic Fc domain is engineered to increase binding affinity to activating Fc receptors to enhance activation of natural killer (NK) cells and other immune cells such as macrophages, which play a role in immunity by engulfing and digesting foreign material. Xencor's cytotoxic Fc technology is currently in multiple clinical-stage programs and one approved therapy, MorphoSys' Monjuvi (tafasitamab-cxix).

Ultomiris is a registered trademark of Alexion Pharmaceuticals, Inc. Monjuvi is a registered trademark of MorphoSys AG.

About Xencor, Inc.

Xencor is a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases. Currently, 22 candidates engineered with Xencor's XmAb technology are in clinical development internally and with partners. Xencor's XmAb antibody engineering technology enables small changes to the structure of proteins resulting in new mechanisms of therapeutic action. For more information, please visit http://www.xencor.com.

Forward-Looking Statements

Certain statements contained in this press release may constitute forward-looking statements within the meaning of applicable securities laws. Forward-looking statements include statements that are not purely statements of historical fact, and can generally be identified by our use of words such as potential, can, will, plan, may, could, would, expect, anticipate, seek, look forward, believe, committed, investigational, and similar terms, or by express or implied discussions relating to the efficacy of sotrovimab (VIR-7831), Xtends ability to enhance the immune function of novel antibodies, including by extending antibody drug half-life and reducing dosing frequency in patients, the ability of XmAb Fc technologies, generally, to enhance antibody effectiveness and facilitate the rapid development of potential treatments for COVID-19 and other serious infectious diseases, the importance of antibody treatments to reduce the number of hospitalizations and deaths due to COVID-19, Xencors eligibility to receive royalties and sales-based milestone payments under its agreements with Vir, as well as the likelihood, timing and magnitude of such payments, and other statements that are not purely statements of historical fact. Such statements are made on the basis of the current beliefs, expectations, and assumptions of the management of Xencor and are subject to significant known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements and the timing of events to be materially different from those implied by such statements, and therefore these statements should not be read as guarantees of future performance or results. Such risks include, without limitation, the risks associated with the process of discovering, developing, manufacturing and commercializing drugs that are safe and effective for use as human therapeutics and other risks described in Xencor's public securities filings. For a discussion of these and other factors, please refer to Xencor's annual report on Form 10-K for the year ended December 31, 2020 as well as Xencor's subsequent filings with the Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. This caution is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, as amended to date. All forward-looking statements are qualified in their entirety by this cautionary statement and Xencor undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof, except as required by law.

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Sotrovimab (VIR-7831), an Investigational Antibody Utilizing Xencor's Xtend Technology, Receives U.S. FDA Emergency Use Authorization for the...

Researchers studying the relationship between aging and the ability to cope with stress found that the limits of a human lifespan lie anywhere from 120 to 150.

Based on data collected from an iPhone app and medical records from volunteers in both the United States and United Kingdom, the studys authors measured subjects resilience to stressors. With age, the researchers found a decline in the subjects ability to recover.

As we age, more and more time is required to recover after a perturbation, and on average we spend less and less time close to the optimal physiological state, study author Timothy V. Pyrkov said in a press release.

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The study, which was published in the scientific journal Nature, additionally found that even the healthiest volunteers were subject to the same fundamental laws of aging. The group concluded that no strong life extension is possible by preventing or curing diseases without without intercepting fundamental laws of the aging process.

"Aging in humans exhibits universal features common to complex systems operating on the brink of disintegration, said Peter Fedichev, co-founder and CEO of Gero, a biotech company involved in the research.

This work is a demonstration of how concepts borrowed from physical sciences can be used in biology to probe different aspects of senescence and frailty to produce strong interventions against aging, he added in the press release.

America is changing faster than ever! Add Changing America to your Facebook or Twitter feed to stay on top of the news.

Andrei Gudkov, senior vice president and chair of the Department of Cell Stress Biology at Roswell Park Comprehensive Cancer Center, was involved in the study and called the research a conceptual breakthrough.

It explains why even most effective prevention and treatment of age-related diseases could only improve the average but not the maximal lifespan unless true anti-aging therapies have been developed, Gudkov concluded.

The oldest human on record lived to be 122.

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Scientists have determined the oldest age humans can live to | TheHill - The Hill