Category Archives: Life Extension

ADG20 Continues to be Well Tolerated in Healthy Volunteers with Prolonged Half-Life and Serum Virus Neutralization Activity Observed out to Six Months in Ongoing Phase 1 Study

Data from Quantitative Systems Pharmacology/Whole-Body Physiologically Based Pharmacokinetic Modeling Support Evaluation of 300 mg Intramuscular Dose of ADG20 Given as a Single Intramuscular Injection in Ongoing Phase 2/3 Studies

Data to be Presented During IDWeek 2021 and 19th Annual Discovery on Target Conference

WALTHAM, Mass., Sept. 29, 2021 (GLOBE NEWSWIRE) -- Adagio Therapeutics, Inc., ( ADGI) a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of antibody-based solutions for infectious diseases with pandemic potential, today announced new data from the companys COVID-19 antibody program. Updated, six-month data from its ongoing Phase 1 study of ADG20 in healthy participants and data validating the selection of the 300 mg intramuscular (IM) dose given as a single injection that is being evaluated in the companys ongoing global Phase 2/3 treatment (STAMP) and prevention (EVADE) clinical trials will be presented during four poster sessions at the Infectious Disease Society of Americas IDWeek 2021, being held from Sept. 29 Oct. 3, 2021. In addition, Adagios chief scientific officer, Laura Walker, Ph.D., will present a subset of the ADG20 Phase 1 data as well as background on the identification and optimization of this differentiated antibody clinical candidate in an oral presentation at the 19th Annual Discovery on Target Conference on Sept. 30, 2021.

The continued strength of the safety and pharmacokinetic data from our Phase 1 study is encouraging and further underscores the potential impact an antibody like ADG20 which was designed to be potent, broadly neutralizing and delivered as a single IM injection could have on people with or at risk of COVID-19, said Lynn Connolly, M.D., Ph.D., chief medical officer of Adagio. These Phase 1 data combined with our dose selection strategy, which relied on our innovative modeling approach, have allowed us to initiate and advance our pivotal trials of ADG20 in the treatment and prevention of COVID-19. We anticipate these data will support an Emergency Use Authorization (EUA) application in the first quarter of 2022, which could enable us to bring an important treatment option to patients.

Phase 1 Trial UpdateAdagio is evaluating ADG20 in a Phase 1 randomized, double-blind, placebo-controlled single ascending-dose study to assess safety and tolerability, pharmacokinetics (PK), immunogenicity, and serum virus neutralizing activity of ADG20 ex vivo against SARS-CoV-2. Data from a six-month evaluation timepoint confirmed the extended half-life of ADG20, which approached 100 days based on data from the 300 mg IM dose that was given as a single injection. In addition, 50% serum virus neutralization titers at six months after a 300 mg IM dose of ADG20 were similar to observed peak titers with the mRNA-1273 vaccine and exceeded those achieved with the AZD1222 vaccine series. Importantly, ADG20 was well tolerated with no study drug-related adverse events (AEs), serious AEs, or injection-site or hypersensitivity reactions reported through a minimum of three months follow-up across all cohorts. Participants will continue to be followed through 12 months to assess safety and tolerability, PK, immunogenicity and serum virus neutralizing activity.

Phase 1 Poster Information: (633) Preliminary Results from a Phase 1 Single Ascending-Dose Study Assessing Safety, Serum Viral Neutralizing Antibody Titers (sVNA), and Pharmacokinetic (PK) Profile of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)

Dose Selection StrategyTo support dose selection for Adagios global Phase 2/3 STAMP and EVADE clinical trials, the company modified an existing quantitative systems pharmacology whole-body physiologically-based pharmacokinetic (QSP/PBPK) model to better characterize the PK of extended half-life monoclonal antibodies in serum and key sites of viral replication in the respiratory tract. Adagios model adequately a priori predicted the observed ADG20 serum PK in non-human primates (NHPs) and humans. The model was further optimized based on data from Adagios Phase 1 clinical trial and then applied for dose selection for STAMP and EVADE.

For the STAMP treatment trial, data compiled to date suggest that the 300 mg IM regimen has a projected ability to rapidly achieve and maintain target concentrations at key tissue sites of viral replication, including the ability to attain near complete (> 90%) and durable (> 28-day) SARS-CoV-2 receptor occupancy across a range of baseline viral loads. Further, for the EVADE prevention trial, data compiled to date suggest the 300 mg IM regimen has a projected ability to rapidly exceed target serum concentrations in the majority of simulated patients and to maintain potentially effective concentrations for up to 12 months.

Dose Selection Poster Information

The STAMP and EVADE clinical trials are currently ongoing and enrolling patients globally. For more information, please visit clincialtrials.gov.

About ADG20ADG20, a monoclonal antibody targeting the spike protein of SARS-CoV-2 and related coronaviruses, is being developed for the prevention and treatment of COVID-19, the disease caused by SARS-CoV-2. ADG20 was designed and engineered to possess high potency and broad neutralization against SARS-CoV-2 and additional clade 1 sarbecoviruses, by targeting a highly conserved epitope in the receptor binding domain. ADG20 displays potent neutralizing activity against the original SARS-CoV-2 strain as well as all known variants of concern. ADG20 has the potential to impact viral replication and subsequent disease through multiple mechanisms of action, including direct blocking of viral entry into the host cell (neutralization) and elimination of infected host cells through Fc-mediated innate immune effector activity. ADG20 is administered by a single intramuscular injection, and was engineered to have a long half-life, with a goal of providing both rapid and durable protection. Adagio is advancing ADG20 through multiple clinical trials on a global basis.

About Adagio TherapeuticsAdagio ( ADGI) is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of antibody-based solutions for infectious diseases with pandemic potential. The companys portfolio of antibodies has been optimized using Adimabs industry-leading antibody engineering capabilities and is designed to provide patients and clinicians with a powerful combination of potency, breadth, durable protection (via half-life extension), manufacturability and affordability. Adagios portfolio of SARS-CoV-2 antibodies includes multiple, non-competing broadly neutralizing antibodies with distinct binding epitopes, led by ADG20. Adagio has secured manufacturing capacity for the production of ADG20 with third-party contract manufacturers to support the completion of clinical trials and initial commercial launch. For more information, please visit http://www.adagiotx.com.

Forward Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as anticipates, believes, expects, intends, projects, and future or similar expressions are intended to identify forward-looking statements. Forward-looking statements include statements concerning, among other things, the timing, progress and results of our preclinical studies and clinical trials of ADG20, including the timing of our planned EUA application, initiation and completion of studies or trials and related preparatory work, the period during which the results of the trials will become available and our research and development programs; our ability to obtain and maintain regulatory approvals for, our product candidates; our ability to identify patients with the diseases treated by our product candidates and to enroll these patients in our clinical trials; our manufacturing capabilities and strategy; and our ability to successfully commercialize our product candidates. We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements and you should not place undue reliance on our forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause our actual results to differ materially from the results described in or implied by the forward-looking statements, including, without limitation, those risks described under the heading Risk Factors in Adagios prospectus filed with the Securities and Exchange Commission (SEC) on August 6, 2021 and in Adagios future reports to be filed with the SEC, including Adagios Quarterly Report on Form 10-Q for the quarter ended June 30, 2021. Such risks may be amplified by the impacts of the COVID-19 pandemic. Forward-looking statements contained in this press release are made as of this date, and Adagio undertakes no duty to update such information except as required under applicable law.

Contacts:Media Contact:Dan Budwick, 1AB[emailprotected]

Investor Contact:Monique Allaire, THRUST Strategic Communications[emailprotected]

Original post:

Adagio Therapeutics Announces - GuruFocus.com

Congress is considering implementing measures that would make it more difficult for the U.S. Navy to retire many of its aging surface ships.

The Fiscal Year 2022 National Defense Authorization Act, published earlier this week, contains sweeping language that would require the service to seek a waiver from the secretary of the Navy in order to retire its ships early. The waiver must certify that: (A) maintaining the battle force ship in a reduced operating status is not feasible; (B) maintaining the ship with reduced capability is not feasible; (C) maintaining the ship as a Navy Reserve unit is not feasible; (D) transferring the ship to the Coast Guard is not feasible; (E) maintaining the ship is not required to support the most recent national defense strategy required by section 113(g) of this title; and (F) maintaining the ship is not required to support operational plans of any combatant commander.

The provision, first reported by Defense News, puts the onus on the secretary to explicitly consider every possible option short of retirement and to assert that the proposed retirement will in no way affect the overall defense strategy or the obligations of individual commanders.

The Navy seeks to retire seven Ticonderoga-class of guided-missile cruisers and four littoral combat ships (LCS) in the fiscal year 2022. The former includes Anzio, Port Royal, Hu City, San Jacinto, Vella Gulf,Lake Champlain, and Monterey; the latter, Freedom, Detroit, Little Rock, and Fort Worth. The Navy has expressed concerns that the aging Ticonderoga-class cruisers are becoming increasingly more difficult to repair, maintain, and refit. The service is engaged in a wide-ranging life extension program for its 22-strong Ticonderoga fleet, but those efforts are being stymied by rampant cost overruns and work availability delays. The cruisers right now in the modernization are running 175 percent to 200 percent estimated cost, hundreds of days delayed, Chief of Naval Operations Adm. Mike Gilday told lawmakers at an earlier hearing. The Ticonderoga class will eventually be replaced by the next-generation Large Surface Combatant DDG(X) destroyer, but that program is not expected to enter into an active acquisition stage until at least 2028.

The Navy has been pushing for months to decommission the first batch of LCS vessels, which it described as test ships. That characterization has been disputed by key lawmakers on the House Armed Services Committee (HASC). Im not buying it because we need to look at whats Battle Force 2025, we need to look at what we have today and how we can use it and how we can use it most efficiently, said HASC vice-chair Elaine Luria (D-Va). The idea of divesting of current platforms that still have a usable service life in order to invest in something that we might develop the technology for in the futurepaired with our poor track record on [developing new] platformsjust makes absolutely no sense to me. The lead Freedom-class ship, USS Freedom, is slated to be decommissioned later this month.

Facing tight budgets and other structural spending constraints, the Navy has sought to retire swathes of its aging inventory to free up resources for modern projects, including hypersonic strike weapons and the DDG(X) program. The services divest to invest '' growth strategy has been met with stiff resistance by some lawmakers, who have argued that the Navys downsizing efforts would deal a significant short-term blow to U.S. Navy capabilities at a time of growing Chinese military assertiveness in the Pacific.

Mark Episkopos is a national security reporter for the National Interest.

Go here to see the original:

Congress to Navy: You Can't Retire Those Ships Just Yet - The National Interest

If the application by Energiekontor to the councils Planning and Building Standards Committee on Monday is successful the Pines Burn Windfarm, south west of Lurgiescleuch, near Hawick, would extend its operational life from 25 to 30 years.

The original windfarm application failed to win over Borders councillors and they rejected the scheme in November 2017, saying it would have an adverse impact on the landscape and nearby historical sites.

But reporter Malcolm Mahony overturned the locally-elected members decision, stating that the projects benefits outweighed any impacts on landscape or tourism.

When members meet next week they will be recommended to agree the new application.

A report to the committee states: There is a valid consent for the development of a wind farm at Pines Burn that can lawfully operate for a period of 25 years.

"Extending the operational period of the wind farm for a further five years would allow for a 30-year operation period in total.

"This is commensurate with the duration of consent for other existing wind farms within the Scottish Borders.

"Since consent was originally granted for the development of Pines Burn wind farm, there has been no significant shift in policy or other material changes that would require that the original appeal decision to be re-examined.

"The extension of the operational life of Pines Burn wind farm by five years would be consistent with national energy and national planning policy.

"It would extend the wind farms contribution to renewable energy generation and the reduction of greenhouse gas emissions without resulting in any significantly adverse environmental effects or other material considerations which would conflict with the current local development plan.

Energiekontor had initially wanted to build seven 158.5m-high turbines but agreed to reduce that height after Scottish Natural Heritage raised concerns about the aviation safety lighting that would be required.

Continued here:

Bid is made to extend the life of a Borders windfarm - The Southern Reporter

Fullerton officials have agreed to allow restaurants to serve patrons outdoors for another six months, a move business owners said was much needed to maintain revenue and keep customers safe.

Editors Note: This dispatch is part of the Voice of OC Youth Media program, working with student journalists to cover public policy issues across Orange County. If you would like to submit your own student media project related to Orange County civics or if you have any response to this work, contact Digital Editor Sonya Quick atsquick@voiceofoc.org.

The City Council last Tuesday voted unanimously to extend outdoor dining on either private property or public right-of-way with some council members saying the uncertainty of the pandemic and state mandates may require businesses to continue outdoor dining.

Although the vote was unanimous, some council members said there should be changes and additional regulations are warranted. Restaurant owners who attended the council meeting expressed their desire to be able to continue serving patrons outdoors.

As a 35-year professional musician, I really want to recommend that not only do we have outdoor dining but we also have live music in those outdoor areas, Ron Kobayashi, a jazz pianist at Les Amis restaurant, told the council before the vote. Keep art alive, keep revenue pumping into the city and keep citizens happy and enjoying their time.

Before the COVID-19 pandemic, the Fullerton municipal code allowed for outdoor dining as an extension to a businesss operations. According to a city staff report, the city grandfathered and allowed businesses to use the existing outdoor dining areas without amending their permits, while newer businesses had to amend their permits.

When California restricted indoor dining during COVID-19, Fullerton issued more than 60 permits to allow for outdoor dining and retail operations. According to the agenda report, the outdoor dining program was set to end Sept. 30.

Simon Collier, the owner of The Olde Ship Fullerton, voiced his concern about closing down outdoor dining and live music. My customers are scared, and they want to sit outside, Collier told the council. I have immunocompromised people who want to sit outside, please allow it.

Greg Pfost, the citys temporary director of community and economic development, enumerated the pros and cons of extending the outdoor dining program.

The benefits of discontinuing the program include placing all businesses on an equal footing with other businesses that have struggled during the pandemic, he told the council during the meeting.

Other pros of discontinuing the strategy include reducing staff costs associated with code enforcement, restoring access to public spaces, improving public safety, addressing building occupation concerns, and reducing trash production, Pfost said.

However, the uncertainty of the pandemic and state mandates may require businesses to continue offering outdoor dining. The city may suffer a loss in revenue, and the loss of attraction of outdoor dining in the downtown area, according to the staff report.

Pfost added that the extension would allow enough time for businesses to dismantle their outdoor dining or decide if they want to apply for a continuation of the program under normal regulatory conditions and allow outdoor dining to continue through the holiday season.

Mayor Bruce Whittaker was in favor of extending the program.

Theyre (outdoor dining areas) wildly popular and theyre very successful and so I wouldnt like to see anything that would dampen what we have begun in Fullerton, said Whitaker.

Council member Ahmad Zahra pointed to economic benefits that would warrant a continuation but recommended a framework for permanent outdoor dining.

Staff recommended that businesses apply for outdoor dining permits by Oct. 30. If a business does not obtain a permit, staff recommended that the business discontinue and remove its existing outdoor dining area by Nov. 7.

While he did not oppose the extension, Council member Fred Jung cited public safety and overcrowding as reasons why the city should not continue to allow outdoor dining. He instead urged the council to create something more regulated.

Outdoor dining served as a much needed life line for some of them (these businesses) and I would not want to deny them that, Jung said. It certainly needs to be continued but the form its in right now I could not support it because its a free-for-all. There are bad actors that come into any space that isnt regulated and those bad actors are giving everyone thats doing the right thing a terrible name.

Public safety issues that have arisen due to outdoor dining include an overcrowding of patrons in areas, as well as fire hazards related to certain outdoor installations businesses might have.

As part of the extension of outdoor dining, city staff identified certain elements to address with businesses, including maintaining occupancy levels, limiting alcohol to only be sold alongside food in outdoor dining areas, trash disposal upkeep, and ability for the city to revoke a businesss outdoor dining area if dangerous situations arise.

Related

See the article here:

Fullerton City Council votes to extend outdoor dining for six months, With the Mayor Calling it Wildly Popular - Voice of OC

Australian company Amphibian Aerospace Industries (AAI), which owns the type certificate for the Grumman G-111 amphibious aircraft, has bought Australian aerospace design engineering firm Five Rings Aerospace and the two are working to re-engine the G-111 with Pratt & Whitney PT6 turboprops and put the aircraft type back into production.

Khoa Hoang, chairman of the Amphibian Aerospace Group of Companies, says they are reengining the aircraft with Pratt & Whitney PT6 turboprops using a supplemental type certificate (STC) they are developing under the Australia Civil Aviation Safety Agency (CASA) and US FAA regime. The latter is important so the new production aircraft, the G-111T, can be more readily sold internationally.

AAI has selected the PT6A-67F, a more powerful variant of the PT6. It has 1,700 shaft horse power and is the same variant used on the AirTractor AT-802, an aircraft that carries large payloads.

The aircrafts spec sheet lists maximum take-off weight as 15.2 metric tons (15,200kg). The aircraft will have endurance of 12hrs and a range of 1458nm (2,700km), with a standard load, and a maximum operating altitude of 21,500ft, it says.

The aircraft has a large cabin: 6.23ft high, 7.55ft wide and 26.25ft long.

AAI and Five Rings Aerospace are based in the Australian city of Melbourne. AAI acquired Five Rings Aerospace in 2016, which is now a wholly-owned subsidiary.

The Amphibian Aerospace Group of Companies is negotiating with an undisclosed state/territory government to confirm the place to carry out the STC and manufacture the new aircraft, says Hoang.

The company has a Grumman G-111, local registration VH-NMO and manufacturers serial number 148329, which will be converted to a PT6-powered aircraft and used for obtaining the STC.

VH-NMO is one of the very last G-111 manufactured, says Hoang, adding that a total of 466 Albatross seaplanes were built by Grumman Aircraft from 1947 to 1961. The Albatross includes the G-111 civil aircraft as well as the HU-16 (variants A to E) which is a military aircraft.

The G-111 and HU-16 are both powered Wright Aeronautical piston engines, but Hoang says reengining with the PT6A-67F gives the aircraft more range, power, payload capability and greater fuel efficiency.

He says they chose the PT6 because it is a proven engine platform in a maritime environment. There are many seaplanes, such as the Viking Air DHC-6 Twin Otter, that are powered by the PT6, says Hoang.

The other reason they chose the PT6 is because the engine type is ubiquitous in the market, says Hoang, adding that it is on so many aircraft platforms Beechcraft KingAir, Twin Otter, Cessna Caravan, Pilatus PC-12, Quest Kodiak, etc that it means there is strong spare parts and customer support for the engine around the world.

AAI is very happy with the support we have been receiving from Frank Nel and the team at Pratt & Whitney Canada, says Hoang.

He says the first STC will purely be for reengining the aircraft. The only other significant modification under that STC will be upgrading the cockpit to support the new powerplants. He says it will remain largely an analogue cockpit, but there will be some digital flight instrument displays incorporated.

Hoang says they aim to receive the STC in two years from now and have the first production aircraft come off the assembly line in three to four years from now.

He says the bought Five Rings Aerospace because it gave them immediate aerospace design capability.

Five Rings Aerospace, which is led by its founder and CEO Greg Hanlon, has done previous projects such as: an airframe life-extension program for the Dornier 228-201 that it certified with CASA for Australian operator GAM Air, a bariatric stretcher leading device for the Royal Flying Doctor Service and an ATR 42-320 passenger-to-freighter cargo conversion program for Hevilift Australia.

Amphibian Aerospace Group of Companies also includes Amphibian Aircraft Maintenance, which it created by buying a general aviation maintenance company in New South Wales called Copper Sky that was already maintaining G111 aircraft. It also has Amphibian Air which it created by acquiring air operator certificate holder De Bruin Air, a charter operator based in South Australia. While Hoang is founder and chairman the Amphibian Aerospace Group of Companies, the CEO of AAI is Dan Webster the former managing director of the Australian arm of Elbit Systems.

Hoang says the G-111 may have first been developed in the late 1940s, but an upgraded version of the aircraft has a valuable role to play in the current aviation landscape because it has unique capabilities.

It is the only FAA-certified transport category seaplane that can carry 28 passengers, says Hoang.

Many of the planes operating today are not really seaplanes, they are float planes, which means they can only cope with waves that are 30-40cm high, says Hoang, adding that the G-111T is certified for and has proven capability take off and land in 1.37m-high waves.

He also says most float planes have no toilet, which really limits in practical terms the flight time which you would have to keep within 45mins.

Hoang says he was inspired to develop a seaplane program after attending a conference in Singapore which discussed humanitarian assistance and the need for a platform to rescue refugees at sea in the Mediterranean.

He says he realised there was a need for an amphibious aircraft that could do search and rescue out at sea and also deliver aid shipments onshore.

He says the new G-111T will target five segments: search and rescue, medevac, VIP transport, regular passenger transport (RPT) and cargo.

Theres countries such as India and those in Southeast Asia, Africa, South America and parts of northeast Asia where the economy has developed. People are no longer poor in many of these places so they can afford to fly but the infrastructure has failed to keep up, so they need an amphibious aircraft, says Hoang.

Follow this link:

Australia's Amphibian Aerospace Industries, Type Certificate Holder Of The Grumman G-111 Amphibious Aircraft, To Re-Engine With Pratt & Whitney...

Dates to remember

September

26 Bangs 4-H Club Meeting 3:00pm at Bangs HS Cafeteria

27 4-H Food & Nutrition Information Meeting 5:00pm at the Extension Office

October

4 Brown County 4-H Proclamation at County Commissioners Court

5 Livestock Coalition Meeting 5:00pm at the Extension Office

6 Early 4-H Club Meeting 5:15pm at Double H Mercantile

11 Extension Office Closed for Columbus Day

12 Deadline to RSVP for LIFE 101

16 County and State Lamb/Goat Validation 8:00am at the Youth Fair Barns

19 LIFE 101 Information Meeting 5:00pm at the Extension Office

27 State Heifer Validation 2:00pm at Bob Clarks Pens

4-H enrollment is open in 4-H Connect

The enrollment process for the 2021-2022 4-H year begins August 15, 2021. All 4-H families, new and returning, are encouraged to log in and enroll to become an official 4-H member.

As you begin your enrollment for the year, here are some tips in using 4-H CONNECT:

If you already have a profile DO NOT create another one!

If you lost your email and password, call the county office so we can reset, it for you.

An active membership will not be granted until the $25.00 participation fee is paid on 4-H Connect!

You cannot register or participate in an event until your profile is ACTIVE.

When you are doing your re-enrollment for the 2021-2022 4-H Year please make sure you update your address, phone number, and e-mail address.

For any youth who is joining 4-H in 2021-2022 for the first time as a 3rd grader we ask for you NOT TO ENROLL until September 1st. September 1st is actual first day of the new 4-H year and what is used to calculate grade/age. If a 2nd grader moving into 3rd grade enrolls before September 1st it will tag them as a Clover Kid, not charge an enrollment fee and lock them in as a Clover Kid for the year.

If you experience issues trying to enroll in 4-H currently, we recommend that you wait until September 1st. The system has been updated and currently has issues.

Dont wait until the last minute to enroll because after October 31st the cost increases to $30!!

Benefit account for Bangs 4-H Club leader

Rachel Hall has been an integral Brown County 4-H club manager and volunteer for over 10 years. She is currently undergoing chemotherapy treatments for colon cancer.

A benefit account at Texas Bank, Bangs, has been set up for her. Please help someone who has given so much to our Brown County 4-H youth.

Texas Bank - 501 E Hall St. Bangs, TX 76823

Brown County 4-H food and nutrition information meeting

If you have a youth that would like to participate in Food Show and/or Food Challenge or if you are a volunteer interested in coaching Food Challenge, please attend the meeting on September 27th 5:00pm at the Extension Office.

The purpose of the meeting is to educate adult leaders & youth about the Food Show and Food Challenge contest.

During the meeting will discuss coaches, practices, county food show, and teams. For more information contact the Extension Office.

4-H proclamation

National 4-H Week will be October 3rd through the 9th. 4-Hers will have an opportunity to meet with the Brown County Commissioners, on Monday October 4th at 8am, to have them sign our proclamation and visit with them about what Brown County 4-Hers have accomplished. We would like to see as many 4-Hers there as possible to show our thanks for the support, Brown County has given us.

We will meet here at the Extension Office on Monday October 4th at 8am. So, if you are interested in participating contact the Extension Office by Monday September 27th. You must be enrolled in 4-H to participate. We will provide excused absent letters to your school if you would like to participate.

Livestock coalition meeting

The purpose of this coalition is to help strengthen the livestock program. The Livestock Coalition is in charge of developing workshops/clinics, Brown County 4-H Project Show and other learning opportunities that will assist youth with growth in their project area.

If you have aninterest in being part of this coalition please join us on October 5th, 5pm at Extension Office. Your ideas are welcomed for the improvement of the youth livestock program in Brown County.

Rodeo Austin barrow show update

New for 2022, Rodeo Austin is proud to partner with the Texas Pork Producers Association to host an exclusive Certified Texas Bred Barrow Show. All Barrows must be certified Texas Bred to compete.

4-H Livestock projects

If you are needing assistance with finding a 4-H livestock project such as, lamb, goat, or swine for upcoming county and/or state shows please contact Nick Gonzales or Scott Anderson at the Extension Office.

If you already have your livestock project and would like for the agents to come, check on your project please contact the Extension Office to schedule an appointment.

Lamb, goat and swine county and state validation

It is that time to start getting ready for the Brown County Youth Fair and Major Stock Shows. The most important step in doing this is validating your animals. Lamb/Goat validation will be October 16 at8 a.m. Swine validation November 13 at8 a.m. at the Brown County Youth Fair Barns.

There will not be a county validation make up day.If you are planning on participating in the Brown County Youth Fair, you need to make sure your animal is present the day of validation.If you ordered state tags and have not paid for them, come by the Extension Office ASAP. You must be enrolled in 4-H before the date of validation.

Heifer validation

If you are showing a heifer at a major stock show that has not previously been state validated or has changed owners, they will need to be validated. Heifers that are only participating in the Brown County Youth Fair do not need to be validated.

Please make sure you have registration papers in hand at validation. Every heifer needs to have an ID, either a brand or tattoo. Please ensure that tattoos/brands are done and legible before validation.

Dates to Remember:

October 27 Physical Validation 2:00pm 4:00pm at Bob Clarks pens

November 1 Deadline Original Registration Papers Must be in Exhibitors Name

For more information, contact the Extension Office at 325-646-0386.

Life 101

Life 101 is a youth program that focuses on filling the missing pieces and assisting with the strategies to successfully launch into adulthood. The goal is to eliminate the idea of Learning from their mistakes.

Topics of learning are: banking andmanaging Money; credit cards; financial aid, loans, and scholarships; budgeting; true cost of transportation; interviewing skills andhow to land a job; etiquette & dressing for success.

This program is open to Brown County 4-H members 9th 12th grade. If you are interested in Life 101 there will be an information meeting on October 19at 5 p.m. at the Extension Office. RSVP by October 12if you plan to attend.

Ag Texas Youth of the Month scholarship contest

AgTexas Farm Credit Services is proud to host a program that highlights some of the best and brightest young minds in Texas 4-H and FFA members in the South Plains, Panhandle and Central Texas areas.

The AgTexas AgYouth of the Month program will honor students who excel in the classroom and as leaders in their 4-H clubs and FFA chapters. The purposes of this award are:

To raise the profile of these two organizations by recognizing outstanding senior class leaders within 4-H and FFA.

To recognize these monthly winners in local newspapers and on radio (wherever appropriate), social media and the AgTexas FCS website.

To bring together these outstanding young men and women at the annual banquets.

To create scholarship opportunities that will help graduating seniors afford a college education

If you are a senior in high school and interested in applying for the AgYouth of the month complete your application online at https://www.agtexas.com/news-updates/ag-youth-of-the-month/ag-youth-entry-form/

Read more here:

Brown County 4-H news and updates - Brownwood Bulletin

A new Memorandum of Understanding (MoU) was signed between Turkey and Indonesia at Teknofest 2021 in the Turkish metropolis Istanbul, further strengthening bilateral cooperation.

Aerospace Indonesia, locally known as PT Dirgantara Indonesia (PTDI), and Turkish Aerospace Industries (TAI) signed the MoU to "cooperate in N219 aircraft production extension, modernization and life extension of the Turkish CN235 aircraft fleet," the Indonesian Embassy in Ankara said in a statement.

The two countries will cooperate in engineering support of TAI development projects and in the joint development and production of the N245.

"The MoU (will) improve and strengthen the cooperative relationship that has existed between PTDI and Turkish Aerospace, especially in terms of the N219 aircraft and the modernization of the Turkish CN235 aircraft," the statement added.

Noting the cooperation between PTDI and Turkish companies, the embassy said Indonesia has collaborated with Turkey's defense giant Aselsan in 2000 for the installation of signal intelligence and intelligent communication systems on the CN235 Turkish Air Forces Command aircraft.

"In Teknofest 2021, PTDI is again showcasing its flagship products and services to expand markets and increase sales, especially for the CN235-220 and N219 aircraft," the statement added.

The six-day Teknofest, the countrys biggest technology event that began Tuesday, will continue until Sunday at Atatrk Airport.

Founded in 1976, PTDI is one of Asia's indigenous aerospace companies with core competencies in aircraft design, development and testing, aircraft structure manufacturing, aircraft production and aircraft services for both civilian and military uses, the embassy said.

Read more:

Indonesia, Turkey strengthen aerospace cooperation with new deal | Daily Sabah - Daily Sabah

Rail News Home Railroading Supplier Spotlight

9/23/2021

Rail News: Railroading Supplier Spotlight

AmstedRail Transit, a leading U.S.-based manufacturer of complete bogie systems and end-of-car components, will partner with Alstom to supply 200 new multilevel rail cars for Metra in Chicago. Under the agreement, Amstedwill provide assembled bogie systems, couplers, draft gears and crash energy management systems, which will be integrated with Alstoms rail cars at the Alstom manufacturing facility in Hornell, New York. The base order is for 200 rail cars, with a possibility to expand the offering, Amsted officials said in a press release.

Gowanda Electronics yesterday announced that Chief Executive Officer Donald McElheny retired at the end of August after 24 years with the company. McElheny joined Gowanda Electronics in 1997 as new product development manager. He took on increasing responsibility in subsequent years, being named chief operating officer in 2006. McElheny became CEO in 2011. Gowanda merged withiNRCOREin late 2020.

Trapeze Group and Sentient Science have announced a new collaboration aimed at helping transit agencies budget and optimize rail-maintenance investments. Theinitiativeintegrates Sentient's prescriptive rail-maintenance software with Trapeze's enterprise asset management, capital planning and state-of-good-repair tools. The effort enables transit-rail agencies and railroads to measure the life extension and cost savings from rail grinding, milling and friction management, the companies said in a press release.

Read the original here:

Rail News - Rail supplier news from Amsted, Alstom, Gowanda, Trapeze and Sentient. For Railroad Career Professionals - Progressive Rail Roading

Being a globetrotting DJ and producer doesnt come without its hardships. Steve Aoki has revealed that his hyper-successful career has seen its fair share of obstacles, including holding back on raising a family, missed opportunities with Kanye, Drake and Eminem, suffering from tinnitus, and losing his best friend.

The 43-year-old has performed a whopping 250 shows per year for 15 years. Thats no easy feat, and its significantly impacted his personal life. Theres a point where, in those moments of loneliness and sadness, I made a decision, he explains on In Depth with Graham Bensinger.

Instead of being at home and potentially having a familyI chose this life, and Im on the road a lot, so whoever I end up dating or whoever becomes part of my lifeIts a specialised life. Its only meant for a certain kind of person to be able to live like thisI definitely want to have kidsTheres no doubt about it. Its going to happen.

Thankfully, Aoki has fallen in love with his career, saying that there is no greater high than being on stage. It is the absolute pinnacle. Drugs cannot reach the high that I am getting. I am completely sober. I dont drink before shows. I dont do any drugs. I let the moment and the real raw connection Im having bring me to that level.

The superstar DJ reflects on those moments and tears up at the thought of his friends that have passed. When [those moments] are gone, theyre gone forever. So you better fuckingyou better give 100 per centbecause after that moment has gone, its gone.

Aokis career has undoubtedly rewarded him with unforgettable moments and opportunities. One opportunity that passed him by in the earlier parts of his journey was a remix of Eminems Forever, featuring Drake, Kanye and Lil Wayne.

He recalls how Kanye called him up to share some lyrics he was working on. He then later bumped into Drake, whose team sent him stems of an upcoming track. Its Drake, its Eminem, its Lil Wayne, and its Kanye West, Aoki says. I could remix the biggest voices of my career.

It never actually ever came out because it just wasnt that good. Sad to say, but thats life. I had the opportunity it wasnt good at the time. If they gave me the opportunity now, itd be a different story.

Bensinger asks Aoki about another affliction of his high-octane career tinnitus. The tinnitus in my left ear; now I have a little bit in my right. Its just part of life, Aoki explains. Ive learned to live with it.

He may have had a turbulent career at times, but Aoki is keen to stick around for as long as possible. My passion is in whats in the future with brain technology The angle is finding a way to live foreverMy moms 78. I want to see her live to 120; I want to say, Mom, you have another 50 more years left, you know?.

Aoki is encouraging his entire family to cryogenically freeze their bodies via the Alcor Life Extension Foundation. He elaborates: Alcor is a facility that deep freezes your bodyIf Im so lucky to die in a hospital situation where they can move my whole body and quickly get my body my brain most importantly into this deep kelvin temperature, andif theres technology to actually bring you back, then I could come back.

But its like, the sad thing is, I dont want to come back and my whole familys gone. Thats why Imasking my whole family, lets at least all do it together, you know?

The full In Depth with Graham Bensinger interview airs this weekend in the US.

Read the rest here:

Steve Aokis Kanye, Drake and Eminem remix never released because it just wasnt that good - MusicTech

Venture Logo From https://makwacahill.ca/

An Indigenous-owned venture focused on industry fabrication has signed a supplier agreement with Bruce Power.

Bruce Power says Makwa Development Corp., which is owned by Nawash residents Scott Lee and Shane Chegano, has joined forces with one of Canadas largest construction companies, Cahill Constructors Ltd. to create Makwa-Cahill.

A release says, In the spirit of Maawanjiodiwag, which means coming together, Makwa-Cahill will collaborate to deliver services to nuclear and energy clients through its fabrication facility in Owen Sound.

Makwa Developments President Scott Lee says in a statement, The nuclear industry is vital to meeting the electricity needs of Ontario, adding, We are pleased to have Makwa-Cahill enter into this supplier agreement with Bruce Power, and ensuring that our Indigenous communities will have a key ongoing role in the nuclear industry.

Makwa-Cahill President Mike Benham says it is a fully qualified Indigenous fabrication company, adding, Once we are in the work-execution phase, we will hire and provide on-the-job training for skilled tradespeople to meet the needs of Bruce Power and other energy sector clients in Ontario.

Bruce Power President and CEO Mike Rencheck, says Bruce Powers Life-Extension Program sets a long-term framework for the relationship, noting, The Makwa-Cahill joint venture will advance job creation for skilled tradespeople from Georgian College and the Saugeen Ojibway Nation, helping provide Bruce Power and our nuclear supply chain with the skillsets required to advance our long-term investment program.

Ontario Minister of Indigenous Affairs and Minister of Northern Development, Mines, Natural Resources and Forestry, Greg Rickford, applauds the partnership, saying These are the types of partnerships that support economic development, create good jobs, and provide opportunities for First Nations communities to share in Ontarios prosperity.

Learn more about Makwa-Cahill at makwacahill.ca

Read more:

Bruce Power Inks Supplier Agreement With Indigenous-Owned Venture - Bayshore Broadcasting News Centre