Category Archives: Alternative Medicine

Government initiatives play a major role in propelling the demand for integrative health and complementary medicine practices by strengthening targeted expenditure, setting up government facilities, and releasing guidelines to ensure appropriate usage of complementary and alternative medicine (CAM). Regulatory bodies are also focusing on the promotion of medical tourism as it attracts people from other places and helps them seek world-class alternative medical treatment. For instance, Indian regulatory authorities have made significant investments in the development and standardization of alternative medical facilities in some of the states.

Conventional and Alternative Pain Treatment Marketresearch is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors.

Get Sample Copy Of This Report With Global Industry Analysis: http://www.a2zmarketresearch.com/sample?reportId=357644

Conventional and Alternative Pain Treatment Market is growing at a 22.03% CAGR during the forecast period 2021-2027. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

Business strategies of the Conventional and Alternative Pain Treatment key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis. It also provides market information in terms of development and its capacities.

Top Players Are: Abbott Laboratories, Baxter International, Eli Lilly & Co., GlaxoSmithKline, and Johnson & Johnson

Global Conventional and Alternative Pain Treatment Market research report offers:

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Conventional and Alternative Pain Treatment market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Conventional and Alternative Pain Treatment markets trajectory between forecast periods.

Enquire For Exclusive Customized Report: http://www.a2zmarketresearch.com/enquiry?reportId=357644

The cost analysis of the Global Conventional and Alternative Pain Treatment Market has been performed while keeping in view manufacturing expenses, labor cost, and raw materials and their market concentration rate, suppliers, and price trend. Other factors such as Supply chain, downstream buyers, and sourcing strategy have been assessed to provide a complete and in-depth view of the market. Buyers of the report will also be exposed to a study on market positioning with factors such as target client, brand strategy, and price strategy taken into consideration.

Table of Content (TOC)

Global Conventional and Alternative Pain Treatment Market Report 2021 Growth, Trend and Forecast to 2027

Chapter 1 Conventional and Alternative Pain Treatment Market Overview

Chapter 2 Global Economic Impact on Conventional and Alternative Pain Treatment Industry

Chapter 3 Global Conventional and Alternative Pain Treatment Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region (2014-2021)

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions (2014-2021)

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Conventional and Alternative Pain Treatment Market Forecast (2021-2027)

Chapter 13 Appendix

Key questions answered in the report include:

Buy This Report: http://www.a2zmarketresearch.com/discount?reportId=357644

If you have any special requirements, please let us know and we will offer you the report as you want.

About A2Z Market Research:

The A2Z Market Research library provides syndication reports from market researchers around the world. Ready-to-buy syndication Market research studies will help you find the most relevant business intelligence.

Our Research Analyst Provides business insights and market research reports for large and small businesses.

The company helps clients build business policies and grow in that market area. A2Z Market Research is not only interested in industry reports dealing with telecommunications, healthcare, pharmaceuticals, financial services, energy, technology, real estate, logistics, F & B, media, etc. but also your company data, country profiles, trends, information and analysis on the sector of your interest.

Contact Us:

Roger Smith

1887 WHITNEY MESA DR HENDERSON, NV 89014

[emailprotected]

+1 775 237 4147

Original post:

Conventional and Alternative Pain Treatment Market Research Report Forecast to 2027 Cumulative Impact of COVID-19| Abbott Laboratories, Baxter...

Photo courtesy of True Nature Healing ArtsHow to Live a Better Life Right Now

Day spas are great, but long-term health and happiness require so much more. Here are seven places that offer distinctive, purposeful approaches to soothing body, mind, and spirit.

Has there been a year in recent memory when its been harder to feel and be well? Social and physical restrictions, instituted to keep us healthy, couldnt help but also make us feel so, so bad. This makes it all the more important that in 2021, we define wellness broadlynot just a back massage and cucumber slices over the eyes, but a practice of living that treats the self, the community, and the climate with care and respect. Whether theyre a hundred-person operation or a one-woman show, whether they involve ancestral practice or innovative new inventions, the following wellness experiences aspire to that definition.

Note: 5280 encourages you to do your own research and consider consulting with your doctor before engaging in alternative medicine practices.

Why its special: From muscle work to moon reiki to psychedelic coaching and more, Nurture might fairly be called Denvers wellness mecca. Over 60 independent health practitioners and retailers operate out of Nurtures open-concept building, which also features a cafe, bar, sauna, organic hair salon, and Himalayan salt room. Plan a visit ahead of timeperhaps to see Georgia Grey, who offers holistic nutrition coaching for those who, like her, struggle with autoimmune conditionsor explore the offerings at your leisure. You can even drop off your kids at Nurturelings, a childcare service with mindful programming run by Rebecca Kanov of Arts & Minds. Ultimately, co-founder Peter Strauss wants the space to help you be a true, non-compartmentalized version of yourself.

Whats new in 2021: Nurture just launched a new booking platform, complete with gift certificates that can be spent across almost all the stores and services in the building. Theyre also in the process of launching a corporate wellness program for Colorado businesses.

If you go: 2949 Federal Blvd.; Prices vary between practitioners; Nurtures spaces are open to the public.

Why its special: Medical clinician Nancy Rae Kochis (Apache Nation of Colorado, Carlana Tribe, Mountain Buffalo Band) orchestrates a network of indigenous health workers in rural communities and reservation areas across seven states. The intention behind our medicine is justice, Kochis says. That survivors get help, and that perpetrators and their descendants also find peace. Anyone, including non-Natives, can sign up for telehealth appointments on their client portal to learn about and involve themselves in Herbal Gardens lifestyle health practices, which combine Western medicine with two millenia-worth of botanical and spiritual Apache teachings. Herbal Gardens, a nonprofit organization, then takes earnings from these classes, as well as grants from organizations like the Chinook Fund, and uses them to care for Native people most in hope (a term Kochis prefers to in need) across the West. This looks something like Kochis reviewing medical records for someone who needed retinal reattachments, speaking with a Lakota woman about treatment options, and coordinating a grocery drop-off for a diabetic woman soon to return from surgery.

Whats new in 2021: Most of Herbal Gardens work with non-Natives is virtual, but Kochis is beginning to host in-person workshops in Hartsel, Colorado and elsewhere this spring.

If you go: A holistic health assessment is $95; a wellness coaching session is $125; Herbal Gardens uses the money from these outward-facing programs to provide health services to indigenous communities free of charge.

Why its special: Tasha Madison opened the only full-day, Black-owned spa in Aurora on February 1 last year. Less than two months later, though, On The Go had to close because of the pandemic. Theyve since reopened with a wide array of mix-and-match spa packages. To help with migraines and fatigue, Madison recommends the oxygen therapy treatment combined with essential oils like eucalyptus and bergamot; the facials and hot stone massages are also quite popular. She prides herself on the cool, relaxing ambience of the lounge, which always has complimentary wine and fresh tea available to sip. And when you leave, grab a bottle of On The Gos essential skincare productsa cleanser, a toner, a moisturizer, and a sunscreento take the guesswork out of your skin health.

Whats new in 2021: The pandemic initially dashed Madisons hopes to host spa parties for bridal showers, but On The Go is now able and eager to accommodate them.

If you go: 2295 S Chambers Rd, Unit I, Aurora; The magnesium foot detox is $65; thirty minutes of oxygen therapy is $25; day spa packages start at $175.

Why its special: From time to time in the wellness world, you might run into practitioners who take themselves too seriouslybut not Curious Sunshines Sarah Iverson, who wants to create a community that allows you to be goofy. Iverson synthesizes influences as diverse as ecopsychology, visual art, and Afropunk to create what she calls quirkshops: collaborative sessions of mindfulness, curiosity, and play designed especially for people of color. (She often partners with groups like Black Womens Alliance and Soul 2 Soul Sisters.) The quirkshops are on pause during the pandemic, but when they resume, attendees can expect to blow bubbles, meditate outdoors, and write group poetry. In the meantime, you can complete puzzles and emotional self-check-ups in Black In Color: A Melanated Activity Guide to Liberation, Iversons wellness activity book.

Whats new in 2021: Iverson is planning an April release of a new online wellness course with a series of modules all about tapping into our inner sunshine.

If you go: Hourlong quirkshops vary in price; Black in Color costs $15.

Why its special: Even though American women experience mental health challenges like depression and anxiety at roughly twice the rate of men, according to a 2017 report by the American Psychiatric Association, amid the responsibilities of work and home life, they seek out mental health specialists less often than their counterparts. With this trend in mind, psychologist and professor Dr. Nikki Jones founded her telehealth womens wellness collective, Rise, in November 2019 to serve clients who could make time to get help during their lunch break or while their kids nap. Rise was conveniently well-situated to adapt to the new, remote normalJones and her Grand Junctionbased team now serve clients across the state and the country. Rises premier offering is its TheraCoaching program, which gives clients virtual, one-on-one sessions with both a licensed psychologist and a life or mindfulness coach. After all, the internal changes necessary for self-actualization are rarely separable from the external onesyou heal from trauma as you change careers, you try to rescript negative self-talk as you adapt to a new exercise routine.

Whats new in 2021: Group workshops for women, starting with but not limited to workplace dynamics, that Jones hopes will be held in-person.

If you go: TheraCoaching sessions start at $100.

Why its special: Natnicha Aey Lappichate couldnt find traditional Thai massages practiced by Thai people when she moved to Colorado in the mid-2000s. So she returned to her native Bangkok to study the art and craft of delicate and deliberate stretching, twisting, pulling, and pushing along a bodys ten energy lineswhat she calls lazy yoga. At Siam Sensation, Lappichate has been practicing, teaching, and refining these techniques for over a decade. Expect to be soothed not just by a masseuses hands and feet but also by time-honored accoutrements like wrapped Thai fabrics and steam-heated herbal balls. The Tok Sen massage, which involves tapping a two-pronged wooden mallet to break down fascia and help with nerve pain, is particularly beloved. Lappichate hopes her customers dont think of massage as an out-of-the-ordinary luxury but as a regular, integral element of their everyday selfcare.

Whats new in 2021: A bamboo roller massage intended to reach ones deep tissue.

If you go: Located at 5330 Manhattan Cir., Suite G, Boulder, and 16 Mountain View Ave., Suite 102, Longmont; $190 for a two-hour Tok Sen massage, $85 for a one-hour foot reflexology massage.

Why its special: What began in 2007 as a 500-square-foot space for meditation and yoga has ballooned into a multi-acre campus dedicated to practically all forms of personal growth. Theres a peace garden, an organic cafe that serves produce grown in the peace garden, a Kiva event center that seats 100, an apothecary, outdoor labyrinth, and a spa specializing in ayurvedic treatments. Locals can drop by just to have a cup of coffee ensconced in gorgeous architecture while out-of-towners can drive up for themed retreats. According to co-founder Eaden Shantay, the four petals of the lotus flower on True Nature Healing Arts logo represent the sites four core values: inspiration, connection, self-discovery, and service.

Whats new in 2021: To hybridize its business model, the center is scaling up its virtual class offerings and online boutique.

If you go: 100 N 3rd Street, Carbondale; Drop-in yoga classes are $18; spa treatments start at $125; retreats start at $220; the peace garden is free.

See more here:

Where to Find Unique Wellness Experiences in Colorado - 5280 | The Denver Magazine

When Jo Anne Schatz, 69, talks about the latest treatment she received for her endometrial cancer, she describes it as an eraser.

It was amazing, Schatz says. It just wiped my cancer out.

The drug, Keytruda (pembrolizumab), is a type of cancer treatment called immunotherapy, designed to harness a persons immune system to identify and destroy the cancer. It is just one of the targeted treatments approved by the Food and Drug Administration (FDA) for or being developed for the treatment of endometrial cancer.

Unlike traditional chemotherapy, which acts against cancer cells and healthy cells alike, targeted treatments are aimed at specific aspects of the cancer cells.

Keytruda hitting its target is what Schatz credits with saving her life.

Schatz, a former addiction specialist from Philadelphia, received a diagnosis of endometrial cancer in May 2015 after experiencing unexpected vaginal bleeding. She had never heard of the disease.

My primary care doctor told me to contact my gynecologist; within two weeks, I was seeing a specialist at Fox Chase Cancer Center and headed in for a complete hysterectomy, Schatz says.

Endometrial cancer is a disease in which cancer cells form inside the lining of the endometrium, or uterus. Vaginal bleeding and pelvic pain are common symptoms.

Endometrial cancer is the most common of all gynecological cancers in the United States, says Dr. Christina S. Chu, professor in the Department of Surgical Oncology at Fox Chase Cancer Center in Philadelphia. Fortunately, the vast majority of endometrial cancers can be treated surgically with the removal of the uterus, ovaries, fallopian tubes and cervix. Most are cured with this surgery plus or minus radiation.

Some patients 13% who receive a diagnosis of endometrial cancer, however, will have their disease recur. After surgery, Schatz underwent several rounds of radiation and chemotherapy to destroy any remaining cancer cells. After a brief remission, her cancer recurred, metastasizing to the peritoneal lining, and her physicians began to look for more targeted treatment options.

When we started to get down to the genomic levels of these tumors, we realized that just because some endometrial cancers may look (similar) under the microscope, they may still behave biologically different based on genomic signature, says Dr. Emily M. Ko, assistant professor of obstetrics and gynecology at Pennsylvania Hospital of Penn Medicine in Philadelphia. Based on that genomic signature, there may be biologic pathways that we can target.

That is what happened to Schatz, who was told that her type of endometrial cancer had a genetic component called MSI-high.

MSI stands for microsatellite instability. When disease is MSI-high, the cancer cells have a high number of mutations within microsatellites, which are short, repeated sequences of the DNA. These signify abnormalities in DNA repair, which can be targeted with certain drugs.

In 2017, the FDA approved Keytruda for use as a treatment for any solid tumor that was MSI-high, had progressed after prior treatment and had no satisfactory alternative treatment options.

This was important for patients with endometrial cancer because (approximately) 30% of patients with endometrial cancer will have tumors that are MSI-high, explains Dr. Shannon N. Westin, associate professor in the Department of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center in Houston.

One study evaluating the use of Keytruda in patients with MSI-high tumors showed that among a small group of women with endometrial cancers, more than half saw their tumor respond to the treatment, and the majority had at least some clinical benefit.

A larger proportion of patients with endometrial cancer will have microsatellite-stable disease, Westin says. For those patients, there is a newer FDA-approved targeted therapy combining Keytruda with Lenvima (lenvatinib).

Indeed, in late 2019, the FDA approved the immuno- therapy Keytruda with Lenvima for patients with endo- metrial cancer that is not MSI-high and whose disease has come back after prior chemotherapy. Lenvima is a multiple-receptor tyrosine kinase inhibitor. The drug works by blocking the action of abnormally activated proteins that signals cancer cells to multiply. A study of this combination showed that approximately one-third of endometrial tumors responded.

Finally, some patients with endometrial cancer may qualify for treatment with a drug targeting NTRK gene fusions, which are estimated to occur in only a small percentage of endometrial cancers. Rozlytrek (entrectinib) and Vitrakvi (larotrectinib) are approved for adults who have solid tumors with this specific genetic alteration.

Not every endometrial cancer that comes back or spreads will have one of the characteristics to qualify for the currently available targeted treatments. These women may want to ask their physicians about potential alternatives, Ko says.

Kim Bryant, 61, a former special education teacher from Texas, did just that when she was told in May 2019 that her endometrial cancer had spread. After receiving her diagnosis in March 2016, Bryant initially underwent surgery and radiation for the cancer. After its first recurrence a year later, she had additional surgery followed by radiation and chemotherapy.

At that point, my local oncologist said he had done all he could and referred me to MD Anderson, Bryant says. I was given a choice between two trials. I was enrolled in one for about a year and my cancer progressed. I have had more success with the second trial.

The second clinical trial is testing a three-drug combination of the hormone therapy Femara (letrozole); Afinitor (everolimus), a drug designed to target a protein called mTOR that promotes cell growth; and Kisqali (ribociclib), a CDK 4/6 inhibitor that is designed to interrupt the cell cycle that drives growth of cancer cells.

CDK 4/6 inhibitors have been studied in breast cancer and are thought to potentially be synergistic when used with other hormonal drugs, Ko says.

For her first clinical trial, Bryant had been making a four- hour drive once a week from Dallas to Houston to receive treatment. On the current trial, all three drugs are oral and can be taken at home.

All three oral treatments (are) so much easier because there are no infusions, Bryant says. I only have to go down once every three months for bloodwork and other testing.

Bryant remains on treatment and says that, so far, the cancer is responding well.

In addition to mTOR and CDK 4/6 inhibitors, clinical trials are also testing a class of drugs that inhibit poly (ADP-ribose) polymerase more commonly known as PARP inhibitors. This class of drugs is approved for certain breast and ovarian cancers that have an inherited mutation in the BRCA gene

or have a certain genomic instability called homologous recombination deficiency (HRD), a type of DNA repair defect.

There are a number of trials exploring these drugs alone or in combination with other targeted agents to see if there is activity in endometrial cancer, Westin says. Probably about 20% of endometrial cancers have mutations in BRCA or other abnormalities in HRD pathway members, but there may be other abnormalities in endometrial cancer that predict benefit, so none of the trials (is) being selective.

There are also trials exploring other immunotherapy drugs that target a protein called PD-1 or PD-L1, immunotherapy drugs in combination with chemotherapy or other targeted agents, and agents targeted against other disease pathways such as the PI3K or MEK pathways, Westin says.

Right now, these targeted therapies are considered second- line treatments given after a first disease recurrence because they are not as effective as primary chemotherapy for most patients, according to Chu.

Trials are ongoing to test targeted therapies in combination with chemotherapy in the first-line setting, though, Chu says.

There have not been any completed clinical trials yet comparing the standard chemotherapy with these new targeted treatments, but they are in progress, according to Ko.

What we are learning is that perhaps side effect profiles may be better in targeted treatment, meaning it may be worthwhile to consider an alternative targeted therapy up front in treatment rather than saving it for down the road, explains Ko.

For example, immunotherapy drugs such Keytruda do not have the traditional side effects seen with chemotherapy, such as hair loss, nausea or vomiting. Because the drug works by attempting to stimulate the immune system, many of the side effects seen with Keytruda are related to the immune system, Chu says. Similarly, side effects seen with Lenvima, which works by affecting blood vessels, can be related to a patients blood vessels, such as high blood pressure.

Schatz says that during her treatment with Keytruda, she experienced muscle aches, pains and fatigue. Other common side effects associated with Keytruda include headache, fever, skin rash, constipation, loss of appetite and diarrhea.

On chemotherapy, I was often sick for a full week, then a little better before preparing to go back for another treatment, Schatz says. On the trial, I was able to cook and care for myself and establish a routine.

Bryant says that side effects during her most recent clinical trial also have been tolerable.

I have had some decrease in appetite and some fatigue, but not enough that it keeps me from doing what I want to do, Bryant says. It has only slowed me down some.

Many of the side effects related to targeted therapies can be managed easily if caught early, Westin says.

This takes good communications between a patient and their health care team and preparation so that a patient knows what to look for, Westin says.

In addition to a patients tumor having the right target, the health care team will consider these possible side effects in their decision on whether a patient might qualify for treatment with a targeted therapy.

We look at the best data we have available, the tumor characteristics and the overall health of each patient to decide if a targeted therapy is best, Ko says.

Schatz credits much of her progress not only to targeted therapy but also to advocating for herself and her treatment. She had one doctor who encouraged her to continue treatment, whereas another told her to stop. Since stopping treatment with Keytruda, Schatz has follow-up scans every four months, as well as other regular monitoring. I am also healthier, she says. I am on a cancer-fighting plant-based diet. I take it one day at a time, but I am grateful to be alive and can feel my creativity coming back.

Bryant, too, has been able to maintain an upbeat, glass-half-full attitude throughout her cancer journey, she says.

I have surrounded myself with my faith, family and friends, she says.

Westin applauds patients such as Schatz and Bryant for raising their voices and sharing their stories about endometrial cancer.

Other tumor types get more attention, but endometrial cancer is one of the only cancer types where the incidence is growing, Westin says. A lot of women with endometrial cancer will be cured, but we have to be aware of their sisters in diagnosis who do not do as well and together raise our voices to shine more light on this problem. Hopefully that will allow us to get more funding and more companies interested in exploring new agents to treat endometrial cancer.

For more news on cancer updates, research and education, dont forget tosubscribe to CUREs newsletters here.

Link:

Targeted Therapies Take Aim at Endometrial Cancer - Curetoday.com - Curetoday.com

Orestis Tsonis,1 Fani Gkrozou,2 Zoi Barmpalia,1 Annamaria Makopoulou,3 Vassiliki Siafaka4

1Department of Obstetrics and Gynaecology, University Hospital of Ioannina, Ioannina, Greece; 2Department of Obstetrics and Gynaecology, University Hospitals of Birmingham, Birmingham, UK; 3School of Psychology, College of Human Sciences, Bangor University, Bangor, Wales, UK; 4Department of Speech and Language Therapy, School of Health Sciences, University of Ioannina, Ioannina, Greece

Correspondence: Orestis TsonisSenior Registrar in Obstetrics and Gynaecology, Department of Obstetrics and Gynaecology, University Hospital of Ioannina, Stavrou Niarchou Avenue, Ioannina, 45500, GreeceTel +306986620604Email orestis.tsonis@gmail.com

Objective: This narrative review aims to identify alternative ways to improve the symptoms of primary dysmenorrhea (PD).Background: PD refers to endometrial painful cramps during the premenstrual period. This condition affects a lot of women worldwide and is accompanied with absenteeism and high economic costs, thus, risk-free, and effective therapeutic approaches are needed. Pharmacological agents such as non-steroidal anti-inflammatory drugs (NSAIDs) and oral contraceptive pills (OCPs), which are widely prescribed for these women, demonstrate adequate efficacy in alleviating pain and discomfort. The long natural course of the disease dictates remedies that focus on lifestyle changes and on improvement of Quality-of-Life (QoL) for women suffering with PD.Materials and Methods: Five major search engines, namely MEDLINE, PubMed, EMBASE, and Cochrane Library were searched for articles published prior to October 2020 focused in PD. A total of 74 paper were included.Discussion: Physical activity, for instance yoga, aromatherapy massage, and other forms of relaxation, vitamins and dietary changes, acupressure and acupuncture,a and some psychological interventions are just few of the proposed health behavior targeted approaches in cases of PD. This review focuses on lifestyle changes and alternative methods that could potentially result in minimizing symptoms of PD and in improving overall QoL for these patients, by providing current scientific evidence on their efficacy.Conclusion: Complementary and alternative medicine practices (CAM) are widely accepted by women. International literature provides controversial scientific evidence, thus further studies need to be conducted in order to prove or disregard their efficacy in cases of PD.

Keywords: primary dysmenorrhea, quality-of-life, therapy, complementary and alternative medicine, pain relief

Primary dysmenorrhea (PD) is recurrent menstrual cramps during the menstrual period and painful menses that are not associated with any other obvious medical pathology, with an indigenous sensation of pain, a few days prior to menstruation, that normally persists approximately, 4872 hours after the onset of menstrual bleeding.1 PD is considered the commonest complaint for adolescents as well as, women of reproductive age, and this condition manifests through a wide variety of symptoms, either physical or affective,2 such as back pain, abdominal and pelvic pain, headaches, migraines, insomnia, nausea, dizziness, fatigue, sweating, cramps, irritability, depression, and emotional instability, with a negative impact on overall Quality-of-Life (QoL) compared to healthy women.1,3 International literature lacks consistent scientific evidence with regards to PDs prevalence, reporting various trends of between 4595% due to different methods of measurements and definitions used worldwide.1,4

This condition is postulated to arise from an abundant production of indigenous prostaglandins that result in an irregular pattern of endometrial contractions along with a decrease in the overall endometrial blood supply. Current medical agents against PD have been well established, such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and COPs (Combined Oral Contraceptives), and act in a way that minimizes the production of prostaglandins. Unfortunately, these drugs come with unpleasant side-effects, such as nausea, vomiting, GI bleeding, acne, and asthma, to name a few, especially when administered for long-term use.3

The long physical course of PD demands therapeutic approaches that regard complementary medications and a holistic management for these patients without jeopardizing patients overall QoL. Patients ought to adopt novel lifestyle targeted habits with regards to nutrition, physical activity, and complementary practices that minimize the effects of PD while improving QoL.3 That said, absenteeism at school and work, which is clearly linked with increased financial cost for society, make this lifestyle targeted change imperative for these patients in order to establish an approach that could relieve individuals suffering from PD by maintaining highest therapeutic efficacy along with improved QoL.

Over the last decades researchers have studied health behaviors change in a wide variety of conditions. Achieving a change in a persons health behaviors is a difficult and complex process. Consequently, the deviations vary and may have a significant impact on the individuals health and on the health system. Theories for understanding and enhancing health beliefs (eg, Health Belief Model, Health Promotion Model, and Theory of Reasoned Action) argue that it is relatively easier to achieve onset, than to maintain it in the long-term. The pattern of health behavior change seems to be common, with high recurrence rates varying early after the change. In addition, social factors influence behavior, with an ambiguous impact on both initiating and maintaining health behavior change.5

In the literature, a plethora of complementary and alternative medicine (CAM) practices and medications have been suggested, but the efficacy of these suggestions remain still controversial.6 Similarly as in the case of post-menopausal symptoms, neutraceutical alternates have been suggested. Women that refuse hormonal replacement treatment (HRT) can potentially use Isoflavones, herbal derivatives, vitamins, and other compounds such as polyphenols.7 Over the last 10 years, CAM therapies have been proposed, especially in regions of Africa and Asia where traditional medicine remains trusted by the majority of patients, therefore, approximately all studies conducted regarding CAM efficacy originated from these countries.2,8,9 Physical activity, for instance yoga, aromatherapy, psychotherapy, and other forms of relaxation, vitamins and dietary changes, acupressure and acupuncture are just few of the proposed lifestyle targeted therapies in cases of PD.3 This review focuses on lifestyle changes that could potentially result in minimizing symptoms of PD and in improving overall QoL for these patients, by providing current scientific evidence on their efficacy.

Five major search engines, namely MEDLINE, PubMed, EMBASE, and Cochrane Library, were searched for articles published prior to October 2020 that matched any combination of the following key words: [primary dysmenorrhea] OR [dysmenorrhea] OR [menstrual pain] AND [life-style] OR [alternative medicine] OR [complementary medicine] OR [diet] OR [physical activity] OR [herbs] OR [acupressure] OR [acupuncture] OR [aromatherapy] OR [heat therapy] AND [emotional support] AND [psychological support] AND [psychotherapy]. Only scientific papers in English were included. A total of 74 papers were included.

This paper presents the results of a narrative review. The review focuses on lifestyle modifications that alleviate painful symptoms in patients suffering from Primary Dysmenorrhea. All complementary and alternative therapeutic approaches focusing on lifestyle changes, that are supported by valid scientific evidence, are presented.

These are nutrition, physical activity, Body Mass Index (BMI), herbs, essential oils, and medical plants. In addition, less explored approaches, the relevant sociocultural issues, and psychological aspects are mentioned, in order to present all the available information in the literature. Acupressure, acupuncture, and reflexology are also mentioned, since these methods are alternative types of medicine which represent a different lifestyle and encourage people to differ their everyday life and habits. They are based on a different philosophy and approach than the general western lifestyle.

Papers addressing secondary dysmenorrhea or other evident pathologies that could cause menstrual pain, such as endometriosis, have been excluded.

Maintaining a healthy diet containing dairy products and fibre has been postulated to positively act against PD symptoms.1 Salt and animal fat restrictions have also been proposed as effective for this condition.10 Interestingly, skipping breakfast is linked with PD, while overall low calorie intake has been found to be a risk factor for this condition.1 A possible pathophysiologic explanation is that a normal BMI is associated with regular ovulation and menses, whereas extreme BMIs lead to a prostaglandin abundance that causes painful menstruation. Scientific evidence remains inconclusive, and further studies need to be conducted in order to check the validity of such hypotheses.

Warm beverages and food were found to be preferred by women suffering from PD in order to alleviate their symptoms. Moreover, women with PD with a family history of PD in their mothers were more likely to adopt a healthier nutrition plan, suggesting that PD awareness might increase lifestyle focused approaches into the management of Primary Dysmenorrhea.11 Reduction in beverages containing caffeine was also a nutritional modality that was adopted by patients with the disease, as well as meat restriction, in order to minimize the unpleasant impact of PD in their QoL.4

A 2016 Cochrane review study revealed the insufficiency of scientific evidence so far, and, while vitamin E supplements are not considered effective, fish oil and vitamin B1 evidence is very limited to safely draw a conclusion about their use in cases of PD.12

With regards to body fitness, maintaining a stable Body Mass Index (BMI), between 1924.9 kg/m2, is associated with lower rates of PD, whereas weight extremes exacerbate painful symptoms in patients with PD, as a recent Chinese cross-sectional study suggests.1

Yoga is considered an excellent tool in reducing pain duration and severity in cases of PD.13 More specifically, women with PD are instructed to follow a 20-minute session daily during their luteal phase, emphasizing in cobra, cat, and fish postures to alleviate their painful symptoms.14 Yoga intervention was associated with improved QoL and decreased physical pain and discomfort.15,16 More specifically, patients with PD who trained by yoga for at least 6 months were more likely to reporthigher levels of energy and concentration, as well as lower occurrence of sleep disturbances, insomnia, and confusion. These patients demonstrated stress relief, more social relationships, and higher work capacity by participating actively in their daily activities.15

Other forms of physical activity, such as isometric exercise and stretching, running, Kegel exercises, and relaxation postures have also been proposed to release pain and discomfort in dysmenorrhea, when performed regularly.1719 It seems that 50 minutes of exercise at least 3-times per week has a positive impact in women suffering from painful menses. Physical activity is an excellent tool in maintaining a healthy body, normal cardiovascular function, and improved emotional balance, while physical inactivity is considered the fourth most important risk factor of mortality worldwide as it is strongly linked with cancer, diabetes, and cardiovascular disease.18 Aerobic activity results in an indigenous release of opioids that improve overall QoL and reduce pain sensitivity in women with PD.18

A wide variety of herbs has been suggested to improve symptoms in patients suffering from PD. Chamomile, fennel, cinnamon, and aloe vera are only a few of the herbal regimens that are proposed to treat the severity of symptoms by their anti-inflammatory and anti-spasmodic properties.3

Chamomile is widely used in European traditional medicine for its analgesic and anti-inflammatory effects. A number of studies have suggested its action on the uterus by increasing blood flow and minimizing pain symptoms for patients with PD. Chamomile has been proven to treat cases of migraines and muscle pain, thus, its potential therapeutic effect on dysmenorrhea is quite possible. Matricaria chamomilla minimizes mood swings, anger, and depression, as well as pain perceived severity, fatigue, and lethargy compared to control group patients that received no medication.12,20

Fennel originated by Umbelliferae contains anethole, fenchone, and limonene, which act as dopamine-like agents.21 Anethole blocks dopamine receptors and inhibits endometrial contractions caused mainly by prostaglandins.3 Thus, fennel supplements decrease pain perception in these patients. Along with the analgesic properties of this plant, mainly used as a herb in Chinese culture, the lack of side-effects during its use make it ideal therapy in cases of PD, where long-term treatment is required. Foeniculum vulgar Mill, publicly known as fennel, lowers pain scores in patients with PD and improves overall QoL.12,22

Zataria multiflora is another commonly used herb in patients suffering from PD due to its inhibitory effect against prostaglandin production. More specifically, thymol, as the main ingredient of this plant, blocks calcium channels that are responsible for endometrial cramps.12 The effect of Zataria multiflora oil has been suggested to minimize the severity of pain in women with PD as well as to shorten the duration of pain.12,23,24

Other herbs, such as ginger (Zingiber officinale),25 Valeriana officinalis,21 Cinnamomum (cinnamon),26 and lavender oil,27 provide pain intensity reduction equal to pharmacological agents, such as mefenamic acid, although their exact therapeutic mechanism remains unclear.20,2836 A 2016 Cochrane 2016 emphasized the existence of limited evidence so far in herbal medicine and proposed further RCTs in order to assess the overall effect of herbal medicine in cases of PD.12 Research in the international literature shows dozens of herbal plants used in PD with promising results. Thus, well-designed RCTs should be employed in order to provide valid scientific evidence on their efficacy since, so far, the findings are inconsistent.

In cases of PD, neuromuscular manipulation and acupressure have been adopted by many patients who consistently report a meaningful improvement in pain intensity and duration.37 Although of low quality, the majority of studies report the effectiveness of this CAM modality in patients suffering from PD.38 Many sites have been proposed, while auricular acupressure gained much popularity due to the simplicity of self-therapy.38 Acupressure by trained personneldemonstrates higher rates of efficacy among studies,39,40 but self-administered acupressure remains a risk-free and efficient CAM modality in patients with dysmenorrhea.39,41 The effect of acupressure has also been proven in cases of obesity, smoking cessation, acne, and emotional stability, but the exact mechanism of action remains unclear.42 In cases of PD though, patients who received acupressure were found to have increased uterine blood flow that potentially minimized the pain and discomfort experienced during menses.38 Many patients adopt manipulative therapy as an adjunct therapeutic tool in the management of PD.43 A recent RCT that investigates the effect of acupressure in PD concluded that manipulating menstrual pain zones during 1015 sessions provided pain relief for patients with PD along with high rates of satisfaction.44 The exact therapeutic duration of each manipulation though needs to be further explored, as international literature fails to present long-term reduction of painful symptoms for these patients.45,46

Many studies so far have praised the effect of acupuncture in minimizing the pain of PD.39,47,48 The evidence shows that acupuncture reached higher overall improvement of pain in these patients compared to NSAIDs monotherapy.19,47,49 Unfortunately, despite the success noted by the vast majority of studies on the subject, the Cochrane Database of Systematic Review found very low quality of evidence, mainly attributed to risk of bias, poor reporting, inconsistency, and risk of publication bias.47 In terms of QoL in women with PD that receive acupuncture alternative therapy, the evidence shows improved physical function, mental health, bodily pain, vitality, social function, and emotional role, while no adverse outcomes by this intervention were reported.3,50 Nevertheless, authors suggest 20-minutes of acupuncture per day applied for half the days of a month during a trimester as effective in reducing dysmenorrhea.48,51 The ost common needle sites for effective acupuncture in these cases, that have been proposed by the international literature, are SP6, BL54, and ST28.52,53

Aromatherapy massage has also been suggested as beneficial in minimizing pain and discomfort in patients with PD. During aromatherapy massage, essential oils are applied directly to the skin, or during a bath, or they are inhaled. Abdominal massage follows as the essential oils, mainly lavender, rose damascene, cinnamon, and clove, penetrate deep within the tissues. A recent metanalysis54 found that aromatherapy massage with the use of these essential oils is superior to placebo oils in reducing pain perception and discomfort in women with PD.55 More specifically, lavender oil was found to be better in alleviating painful symptoms in these patients compared to other mixed essential oils.27,54 Another meta-analysis by Song et al56 confirmed the positive effect of aromatherapy in reducing dysmenorrhea, but the authors underlined the high diversity and heterogeneity among studies that could potentially increase the risk of bias.

Despite the traditional approaches in use, a wide range of futuristic, novel approaches on the management of PD have been documented. Some show evidence of a possible positive effect on painful menses, while others, although widely used, are largely abandoned for this condition, such as homeopathy, due to limited scientific data.57

Hydrotherapy and heat therapy have been proposed as beneficial in pain reduction in cases of PD.58 With regards to hydrotherapy, warm baths and hip/sitz baths have been speculated as therapeutic for painful menses, while Heat patches containing iron chips have also been suggested to provide relief of PD discomfort equal to ibuprofen.59 Nevertheless, a recent systematic review and metanalysis revealed only little-to-moderate pain reduction in heat therapy.19 In other words, the role of naturopathic medicine in general might be subjective and it remains solely down to the womans initiative whether she uses such modalities. Although these practices have existed in European traditional culture since the 18th century, their contemporary use is limited.

Kinesio taping along with body awareness have demonstrated favorable outcomes with regards to minimizing pain during menses in women with PD, but the evidence is not enough to support its use widely. Similar, in that cases more studies are necessary to support or not its efficacy.10 In patients with chronic pain such as PD, studies have shown a distorted body awareness and body sensitivity, thus physiotherapy of any form (kinesio taping, electrotherapy, spinal manipulation, heat therapy, etc.) increases body awareness. The effect size of these interventions, though, is yet to be estimated in future studies.10

Another peculiar approach, in treating symptoms of PD is low-light laser level skin-adhesive therapy (LLLT), reaching a reduction of 83% compared to a placebo, as a randomized, double-blind, placebo-controlled pilot trial suggests.60 Light properties in cases of PD have also been tested with near-infrared belts used by these patients. Authors have suggested that the warmth produced by these tools improves abdominal blood supply and their efficacy can be safely compared to the use of oral analgesics.61

A number of lifestyle modifications has been found to alleviate painful symptoms accompanying PD, which should be examined under a cultural context.11 In other words, Asians and Africans were more likely to trust traditional medicine and to opt into a lifestyle that includes herbs and medicinal plants. In a recent Chinese cross-sectional study, adolescents with PD were more like to reduce physical activity and to adopt heat therapy by using warmer clothes during painful menses. Furthermore, these patients were more likely to change their diet by increasing their warm beverage and food intake. Also, these patients reported low levels of self-meditation, but were more likely to express their negative emotions due to PD to their peers in order to seek emotional support.11 On the other hand, western cultures were more likely to seek medical advice and to use pharmacological agents in order to minimize their painful symptoms and discomfort.4 Interestingly, a recent Malaysian study demonstrated that the need to reduce pharmacological agents was independent to the use of CAM modalities, but CAM users found that the absence of side-effects in CAM therapies improved their QoL62 (Figure 1).

Figure 1 Benefits of lifestyle targeted approaches on the management of PD.

Abbreviations: PD, primary dysmenorrhea; CAM, complementary and alternative medicine; QoL, quality-of-life.

Alcohol consumption and smoking is reported as a risk factor for developing PD.1,4 Unfortunately, at this time the scientific evidence does not quantify alcohol consumption, smoking, or environmental tobacco smoke for patient with PD.4 In general, although no threshold can be estimated, potentially smoking cessation and overall alcohol withdrawal are wise strategies to improve their QoL regardless of the existence of underlying PD.

Socio-economic status seems to play a crucial role in young adolescents during first years of university, when various studies report that the symptoms of PD are accompanied by an extreme severity.1 Possibly, different cultural and religious beliefs seem to exacerbate painful feelings of dysmenorrhea that are exacerbated among peers of different racial backgrounds, as it is usually the case in universities. Women of families of lower monthly income present with severe menstrual pain, a fact that might be explained by the inability to seek medical attention for their condition.1

The correlation between psychological factors and primary dysmenorrhea has been thoroughly described in the literature.63,64 The experience of recurrent menstrual pain increases the risk of mental disorders and especially stress, anxiety, and depression, but also alcohol abuse and somatic symptoms disorders.64 In addition, the comorbidity of dysmenorrhea and depression may contribute to an increased focus on symptoms and by extent on the perceived intensity of pain.63,65

The tendency to maximize negative thoughts about pain is known as pain catastrophizing and seems to be associated with the frequency and intensity of pain and emotional distress, as well as with the consequent decreased functionality. Research suggests that women with dysmenorrhea report high levels of catastrophizing pain,66 as well as increased pain intensity, lower perceived effectiveness of over-the-counter drugs, and significant lack of functionality.67 Although it remains unclear whether pain catastrophizing is a personality trait or a coping strategy, it seems to be associated with the adoption of poor coping strategies both cognitively (eg, distraction and imagery) and behaviorally (eg, reduced activity).6769

It is widely accepted that the experience of pain should be considered through an interdisciplinary approach. Support programs, and in particular those including the Cognitive Behavioral Therapy (CBT), appear to be effective in increasing knowledge about primary dysmenorrhea and reconstructing dysfunctional cognition with more rational ones, as well as increasing self-regulation skills. These interventions result in a better understanding of the meaning of pain, decrease of symptoms, and reduction of analgesic use.70,71 Well-designed studies are needed for a deeper understanding of the relationship between common mental health conditions and primary dysmenorrhea that will ensure a better clinical approach.

Since it has been well-established that body image awareness and general health perception affect the intensity and duration of pain for these women, trained specialists should promote a more holistic approach by integrating lifestyle changes into the management of primary dysmenorrhea.62,72,73 Lifestyle alterations could benefit the overall health of these women and improve their Quality-of-Life.74 Figure 2 comprises the aforementioned lifestyle focused approaches into the management of PD.

Figure 2 Integrating lifestyle focused approaches into the management of PD.

Abbreviations: BMI, body mass index; CAM, complementary and alternative medicine.

CAM modalities seem to be widely accepted and adopted by women in adolescence or of reproductive age affected with perimenstrual pain and discomfort. International literature provides controversial scientific evidence with regards to their benefits, while the majority of them hide undocumented risks.

CAM approaches are non-pharmacological and promise to offer relief and to reduce side-effects. These CAM remedies are often self-prescribed with little or no professional caregivers oversight, thus further studies need to be conducted in order to prove or disregard their efficacy in cases of PD.

All authors declare no conflicts of interest nor funding of any kind.

1. Hu Z, Tang L, Chen L, Kaminga AC, Xu H. Prevalence and risk factors associated with primary dysmenorrhea among Chinese female university students: a cross-sectional study. J Pediatr Adolesc Gynecol. 2020;33(1):1522. doi:10.1016/j.jpag.2019.09.004

2. Fisher C, Sibbritt D, Hickman L, Adams J. A critical review of complementary and alternative medicine use by women with cyclic perimenstrual pain and discomfort: a focus upon prevalence, patterns and applications of use and users motivations, information seeking and self-perceived efficacy. Acta Obstet Gynecol Scand. 2016;95(8):861871. doi:10.1111/aogs.12921

3. Sharghi M, Mansurkhani SM, Ashtary-Larky D, et al. An update and systematic review on the treatment of primary dysmenorrhea. J Bras Reprod Assist. 2019;23(1):5157. doi:10.5935/1518-0557.20180083

4. Fernndez-Martnez E, Onieva-Zafra MD, Laura Parra-Fernndez M. Lifestyle and prevalence of dysmenorrhea among Spanish female university students. PLoS One. 2018;13(8):111. doi:10.1371/journal.pone.0201894

5. Lippke S, Ziegelmann JP. Theory-based health behavior change: developing, testing, and applying theories for evidence-based interventions. Appl Psychol. 2008;57(4):698716. doi:10.1111/j.1464-0597.2008.00339.x

6. Fisher C, Adams J, Hickman L, Sibbritt D. The use of complementary and alternative medicine by 7427 Australian women with cyclic perimenstrual pain and discomfort: a cross-sectional study. BMC Complement Altern Med. 2016;16(1):111. doi:10.1186/s12906-016-1119-8

7. De Franciscis P, Colacurci N, Riemma G, et al. A nutraceutical approach to menopausal complaints. Medicina. 2019;55(9):544. doi:10.3390/medicina55090544

8. Fisher C, Hickman L, Adams J, Sibbritt D. Cyclic perimenstrual pain and discomfort and Australian womens associated use of complementary and alternative medicine: a longitudinal study. J Womens Health. 2018;27(1):4050. doi:10.1089/jwh.2016.6253

9. Dias SFL, Pereira LCA. Scientific and technological prospection on transdermal formulations and complementary therapies for the treatment of primary dysmenorrhea. Expert Opin Ther Pat. 2019;29(2):115126. doi:10.1080/13543776.2019.1562547

10. Doan H, Erolu S, Akbayrak T. The effect of kinesio taping and lifestyle changes on pain, body awareness and quality of life in primary dysmenorrhea. Complement Ther Clin Pract. 2020;39:101120. doi:10.1016/j.ctcp.2020.101120

11. Chen L, Tang L, Guo S, Kaminga AC, Xu H. Primary dysmenorrhea and self-care strategies among Chinese college girls: a cross-sectional study. BMJ Open. 2019;9(9):e026813. doi:10.1136/bmjopen-2018-026813

12. Pattanittum P, Kunyanone N, Brown J, et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016;2016(3). doi:10.1002/14651858.CD002124.pub2

13. Kim SD. Yoga for menstrual pain in primary dysmenorrhea: a meta-analysis of randomized controlled trials. Complement Ther Clin Pract. 2019;36(February):9499. doi:10.1016/j.ctcp.2019.06.006

14. Rakhshaee Z. Effect of three yoga poses (cobra, cat and fish poses) in women with primary dysmenorrhea: a randomized clinical trial. J Pediatr Adolesc Gynecol. 2011;24(4):192196. doi:10.1016/j.jpag.2011.01.059

15. McGovern CE, Cheung C. Yoga and quality of life in women with primary dysmenorrhea: a systematic review. J Midwifery Womens Health. 2018;63(4):470482. doi:10.1111/jmwh.12729

16. Fernndez-Martnez E, Onieva-Zafra MD, Parra-Fernndez ML. The impact of dysmenorrhea on quality of life among Spanish female university students. Int J Environ Res Public Health. 2019;16(5):713. doi:10.3390/ijerph16050713

17. Azima S, Bakhshayesh HR, Kaviani M, Abbasnia K, Sayadi M. Comparison of the effect of massage therapy and isometric exercises on primary dysmenorrhea: a randomized controlled clinical trial. J Pediatr Adolesc Gynecol. 2015;28(6):486491. doi:10.1016/j.jpag.2015.02.003

18. Ortiz MI, Corts-Mrquez SK, Romero-Quezada LC, Murgua-Cnovas G, Jaramillo-Daz AP. Effect of a physiotherapy program in women with primary dysmenorrhea. Eur J Obstet Gynecol Reprod Biol. 2015;194:2429. doi:10.1016/j.ejogrb.2015.08.008

19. Armour M, Sinclair J, Chalmers KJ, Smith CA. Self-management strategies amongst Australian women with endometriosis: a national online survey. BMC Complement Altern Med. 2019;19(1). doi:10.1186/s12906-019-2431-x

20. Sultana A, Lamatunoor S, Begum M, Qhuddsia QN. Management of Usr-i-Tamth (menstrual pain) in unani (greco-islamic) medicine. J Evid Based Complement Alternat Med. 2017;22(2):284293. doi:10.1177/2156587215623637

21. Pellow J, Nienhuis C. Medicinal plants for primary dysmenorrhoea: a systematic review. Complement Ther Med. 2018;37(November2017):1326. doi:10.1016/j.ctim.2018.01.001

22. Abdollahi NG, Mirghafourvand M, Mollazadeh S. The effects of fennel on menstrual bleeding: a systematic review and meta-analysis. J Complement Integr Med. 2018;15(3):113. doi:10.1515/jcim-2017-0154

23. Hashemi SA, Azadeh S, Nouri BM, Navai RA. Review of pharmacological effects of Zataria multiflora Boiss. (thyme of Shiraz). Int J Med Sci Public Health. 2017;6(8):7884.

24. Iravani M. Clinical effects of Zataria multiflora essential oil on primary dysmenorrhea. J Med Plants. 2009;8(30). doi:10.1016/s1550-8579(06)80120-8

25. Shirvani MA, Motahari-Tabari N, Alipour A. The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial. Arch Gynecol Obstet. 2015;291(6):12771281. doi:10.1007/s00404-014-3548-2

26. Jahangirifar M, Taebi M, Dolatian M. The effect of Cinnamon on primary dysmenorrhea: a randomized, double-blind clinical trial. Complement Ther Clin Pract. 2018;33(June):5660. doi:10.1016/j.ctcp.2018.08.001

27. Raisi Dehkordi Z, Hosseini Baharanchi FS, Bekhradi R. Effect of lavender inhalation on the symptoms of primary dysmenorrhea and the amount of menstrual bleeding: a randomized clinical trial. Complement Ther Med. 2014;22(2):212219. doi:10.1016/j.ctim.2013.12.011

28. Pio IDSL, Lavor AL, Damasceno CMD, Menezes PMN, Silva FS, Maia GLA. Traditional knowledge and uses of medicinal plants by the inhabitants of the islands of the so francisco river, Brazil and preliminary analysis of rhaphiodon echinus (Lamiaceae). Braz J Biol. 2019;79(1):8799. doi:10.1590/1519-6984.177447

29. Ghasemzadeh Rahbardar M, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H. Anti-inflammatory effects of ethanolic extract of rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacother. 2017;86:441449. doi:10.1016/j.biopha.2016.12.049

30. He X, Wang X, Fang J, et al. The genus achyranthes: a review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2017;203:260278. doi:10.1016/j.jep.2017.03.035

31. Jan S, Khan MR. Antipyretic, analgesic and anti-inflammatory effects of kickxia ramosissima. J Ethnopharmacol. 2016;182:90100. doi:10.1016/j.jep.2016.02.020

32. Lee H, Choi TY, Myung CS, Lee JA, Lee MS. Herbal medicine (Shaofu Zhuyu decoction) for treating primary dysmenorrhea: a systematic review of randomized clinical trials. Maturitas. 2016;86:6473. doi:10.1016/j.maturitas.2016.01.012

33. Moteetee A, Seleteng Kose L. Medicinal plants used in lesotho for treatment of reproductive and post reproductive problems. J Ethnopharmacol. 2016;194:827849. doi:10.1016/j.jep.2016.10.062

34. Gao L, Jia C, Zhang H, Ma C. Wenjing decoction (herbal medicine) for the treatment of primary dysmenorrhea: a systematic review and meta-analysis. Arch Gynecol Obstet. 2017;296(4):679689. doi:10.1007/s00404-017-4485-7

35. Jesuno FW, Reis JP, Whitaker JCP. Effect of synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice. Inflammopharmacology. 2019;27(3):613620. doi:10.1007/s10787-018-0501-1

36. Seo J, Lee H, Lee D, Jo H-G. Dangguijagyag-san for primary dysmenorrhea. Medicine (Baltimore). 2020;99(42):e22761. doi:10.1097/md.0000000000022761

37. Barassi G, Bellomo RG, Porreca A, Di Felice PA, Prosperi L, Saggini R. Somato-visceral effects in the treatment of dysmenorrhea: neuromuscular manual therapy and standard pharmacological treatment. J Altern Complement Med. 2018;24(3):291299. doi:10.1089/acm.2017.0182

38. Cha NH, Sok SR. Effects of auricular acupressure therapy on primary dysmenorrhea for female high school students in South Korea. J Nurs Scholarsh. 2016;48(5):508516. doi:10.1111/jnu.12238

39. Abaraogu UO, Igwe SE, Tabansi-Ochiogu CS. Effectiveness of SP6 (Sanyinjiao) acupressure for relief of primary dysmenorrhea symptoms: a systematic review with meta- and sensitivity analyses. Complement Ther Clin Pract. 2016;25:92105. doi:10.1016/j.ctcp.2016.09.003

40. Zhao MY, Zhang P, Li J, et al. Influence of de qi on the immediate analgesic effect of SP6 acupuncture in patients with primary dysmenorrhoea and cold and dampness stagnation: a multicentre randomised controlled trial. Acupunct Med. 2017;35(5):332338. doi:10.1136/acupmed-2016-011228

41. Bldt S, Pach D, Eisenhart-Rothe SV. Effectiveness of app-based self-acupressure for women with menstrual pain compared to usual care: a randomized pragmatic trial. Am J Obstet Gynecol. 2018;218(2):227.e1227.e9. doi:10.1016/j.ajog.2017.11.570

42. Zhai SJ, Ruan Y, Liu Y, et al. Time-effective analgesic effect of acupressure ankle strip pressing wrist and ankle acupuncture point on primary dysmenorrhea: study protocol clinical trial (SPIRIT compliant). Med. 2020;99:12. doi:10.1097/MD.0000000000019496

43. Abaraogu UO, Igwe SE, Tabansi-Ochiogu CS, Duru DO. A systematic review and meta-analysis of the efficacy of manipulative therapy in women with primary dysmenorrhea. Explore. 2017;13(6):386392. doi:10.1016/j.explore.2017.08.001

44. zgl S, zelpasaci E, Orhan C, Baran E, Beksa MS, Akbayrak T. Short-term effects of connective tissue manipulation in women with primary dysmenorrhea: a randomized controlled trial. Complement Ther Clin Pract. 2018;33:16. doi:10.1016/j.ctcp.2018.07.007

45. Demirtrk F, Yilar Erkek Z, Alparslan , Demirtrk F, Demir O, Inanir A. Comparison of reflexology and connective tissue manipulation in participants with primary dysmenorrhea. J Altern Complement Med. 2016;22(1):3844. doi:10.1089/acm.2015.0050

46. Ruffini N, DAlessandro G, Cardinali L, Frondaroli F, Cerritelli F. Osteopathic manipulative treatment in gynecology and obstetrics: a systematic review. Complement Ther Med. 2016;26:7278. doi:10.1016/j.ctim.2016.03.005

47. Smith CA, Armour M, Zhu X, Li X, Lu ZY, Song J. Acupuncture for dysmenorrhoea. Cochrane Database Syst Rev. 2016;2016(4). doi:10.1002/14651858.CD007854.pub3

48. Shetty GB, Shetty B, Mooventhan A. Efficacy of acupuncture in the management of primary dysmenorrhea: a randomized controlled trial. J Acupunct Meridian Stud. 2018;11(4):153158. doi:10.1016/j.jams.2018.04.001

49. French L. Dysmenorrhea. Am Fam Physician. 2005;71(2):285292.

50. Gaubeca-Gilarranz A, Fernndez-De-Las-Peas C, Medina-Torres JR, et al. Effectiveness of dry needling of rectus abdominis trigger points for the treatment of primary dysmenorrhoea: a randomised parallel-group trial. Acupunct Med. 2018;36(5):302310. doi:10.1136/acupmed-2017-011566

51. Armour M, Dahlen HG, Zhu X, Farquhar C, Smith CA. The role of treatment timing and mode of stimulation in the treatment of primary dysmenorrhea with acupuncture: an exploratory randomised controlled trial. PLoS One. 2017;12(7):120. doi:10.1371/journal.pone.0180177

52. Armour M, Smith CA. Treating primary dysmenorrhoea with acupuncture: a narrative review of the relationship between acupuncture dose and menstrual pain outcomes. Acupunct Med. 2016;34(6):416424. doi:10.1136/acupmed-2016-011110

53. Wang H, Cao Y, Jin X, et al. Effect of an acupuncture technique of penetrating through zhibian (BL54) to shuidao (ST28) with long needle for pain relief in patients with primary dysmenorrhea: a randomized controlled trial. Pain Res Manag. 2019;2019:16. doi:10.1155/2019/7978180

54. Sut N, Kahyaoglu-Sut H. Effect of aromatherapy massage on pain in primary dysmenorrhea: a meta-analysis. Complement Ther Clin Pract. 2017;27:510. doi:10.1016/j.ctcp.2017.01.001

Go here to see the original:

[Full text] Integrating life-style focused approaches into the managemen | IJWH - Dove Medical Press

BURBANK, Calif., March 16, 2021 (GLOBE NEWSWIRE) -- via NewMediaWire -- Medolife Rx, Inc. ("Medolife"),a global integrated bioceutical company with R&D, manufacturing and consumer product distribution, which is a majority owned subsidiary of Quanta, Inc. (OTC PINK: QNTA),announced today results from an independent efficacy test conducted on the Companys polarization technology where the subject compound showed an increased efficacy of 497 percent when compared to its non-polarized counterpart, validating the polarization technology that is being used in most of Medolifes clinical programs and consumer products.

The aim of the study was to compare the efficacy of polarized and non-polarized Mitragyna speciosa, more commonly known as Kratom. Kratom is a natural ingredient that has been used in herbal medicine since at least the 19th century and more recently has seen an increase in interest as a potential alternative medical treatment to control withdrawal symptoms and cravings caused by addiction to opioids or to other addictive substances such as alcohol. The study measured the Adenosine triphosphate (ATP) production levels in primary human fibroblast cells and that data was used to validate the effectiveness of polarization in cellular functions. Fibroblasts were plated in 96 well plates at 10,000 cells per well and were treated for 24 hours, allowing research as to the percentage change between polarized and non-polarized versions of Kratom.

The results showed that polarization of Kratom demonstrates sufficient polarizability, which is the ability of compounds to absorb photon emission through electromagnetic resonance. The ATP production in the primary human fibroblast cells of the Polarized Kratom sample is 497 percent higher than the Non-Polarized Kratom sample.

The study is important to the Companys overall pharmaceutical and nutraceutical product research and development programs as most of the Companys products utilize the polarization technology, which was designed to increase the potency of single molecules and complex compounds. This study further validates the technology and positions the Company for further research to increase the effectiveness of various APIs, decreasing side effects of harsh compounds as well as the raw material input of medicines and nutraceutical products.

The proprietary polarization technology is the cornerstone of our medical and consumer product development programs, including our Escozine clinical program which is currently in review for product registration as a treatment for COVID-19 in the Dominican Republic, and this study further validates our technology, said Medolife CEO Dr. Arthur Mikaelian. While many pharmaceutical companies are working with new and novel compounds, our company is unique in that we could apply this technology to almost any API, currently in use or in the clinic, to increase the efficacy of those compounds for their intended purposes, a true differentiator in our space. While we may not work with Kratom in the near-term, we plan to further validate our technology with various compounds and eventually bring new clinical programs to our pipeline using the technology, that are in high-impact patient focus areas. We are pursuing clinical programs in the United States as well as in other countries around the world.

Medolifes lead clinical development programs include Escozine, a proprietary formulation consisting of small molecule peptides derived from Rhopalurus princeps scorpions, which is amplified by the Companys polarization technology and is being researched as a treatment of various indications, including COVID-19 and cancer. The Companyrecently announced results from a toxicity studyon the drug candidate that showed that at maximum dose levels the product is non-toxic and safe. The Company is seeking product registration for the treatment of COVID-19 in the Dominican Republic and has filed study data in pre-IND format with the US FDA.

About MedolifeRx

Medolife Rx, Inc. is a global biotechnology company with operations in clinical research, manufacturing, and consumer products. MedolifeRx was created through the merger of Medolife, a private company founded by Dr. Arthur Mikaelia who pioneered the unlaying polarization technology that makes the Companys portfolio of pharmaceutical and nutraceutical products so effective, and Quanta, Inc., a direct-to-consumer wellness product portfolio company. The Companys lead clinical development programs include Escozine, a proprietary formulation consisting of small molecule peptides derived from Rhopalurus princeps scorpions which is amplified by the Companys polarization technology and is being researched as a treatment of various indications, including COVID-19 and cancer. The Company has completed preclinical safety and efficacy research on Escozine and is pursuing product registration and drug approval in various countries, including the United States and throughout Latin America.

Through its subsidiary QuantRx, Medolife manufactures and distributes consumer wellness and nutraceutical products in high-impact consumer areas such as pain relief, beauty, and general wellness. QuantRx products are designed using Dr. Mikaelias polarization technology which applies advances in quantum biology to increase the potency of active ingredients. Currently, QuantRx supports product formulations in pain management, anti-inflammation, skincare, agriculture, nutritional supplements, and plant-based consumables. Ultimately, Quanta's mission is to deliver better, more effective ingredients to elevate product efficacy, reduce waste, and facilitate healthier, more sustainable consumption.

Beyond its own clinical and consumer applications, the polarization technology used by Medolife and its subsidiaries has many potential applications. From potentiating bio-ingredients, to producing more-effective carbon-trapping plants, to transformative anti-aging solutions, Medolife has the opportunity to upend how commercial and pharmaceutical products are made and increase their benefits, while decreasing their chemical concentration.

Forward-Looking Statements

Safe Harbor Statement under the U.S. Private Securities Litigation Reform Act of 1995: This release contains statements that are forward-looking in nature which express the beliefs and expectations of management including statements regarding the Company's expected results of operations or liquidity; statements concerning projections, predictions, expectations, estimates or forecasts as to our business, financial and operational results and future economic performance; and statements of management's goals and objectives and other similar expressions concerning matters that are not historical facts. In some cases, you can identify forward-looking statements by terminology such as "anticipate," "estimate," "plan," "project," "continuing," "ongoing," "expect," "we believe," "we intend," "may," "will," "should," "could," and similar expressions. Such statements are based on current plans, estimates and expectations and involve a number of known and unknown risks, uncertainties and other factors that could cause the Company's future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. These factors and additional information are discussed in the Company's filings with the Securities and Exchange Commission and statements in this release should be evaluated in light of these important factors. Although we believe that these statements are based upon reasonable assumptions, we cannot guarantee future results. Forward-looking statements speak only as of the date on which they are made, and the Company undertakes no obligation to update publicly or revise any forward-looking statement, whether as a result of new information, future developments or otherwise.

Contacts:Phil Sandshttps://ir.quantrx.com/818-659-8052

Kyle Portermedolife@cmwmedia.com858-264-6600

Follow this link:

MedolifeRx Announces Results From Efficacy Test on Polarization Technology Showing 497 Percent Increase in Efficacy of API When Polarized -...

Latest launched research document on Global Complementary and Alternative Medicine Market study of 114 Pages provides detailed analysis with presentable graphs, charts and tables. The Research Study presents a complete assessment of the Market and highlights future trend, growth factors & drivers, leaders opinions, facts, and primary validated market data. The research study provides estimates for Global Complementary and Alternative Medicine Forecast till 2026*.

How to reach that market place and its associated audience with current marketing efforts? Benchmark now the competitive efforts with high growth emerging players and leaders of Complementary and Alternative Medicine Market. Request Sample of Global Complementary and Alternative Medicine Report @:https://www.htfmarketreport.com/sample-report/2999272-global-complementary-and-alternative-medicine-market-report-2020-by-key-players-types-applications-countries-market-size-forecast-to-2026

The in-depth information by segments of the Global Complementary and Alternative Medicine market helps monitor future profitability & to make critical decisions for growth. The information on drivers, trends and market developments focuses technologies, CAPEX cycle and the changing structure industry players of the Global Complementary and Alternative Medicine Market.

Global Complementary and Alternative Medicine Product Types In-Depth: , Botanicals, Acupuncture, Mind, Body, and Yoga & Magnetic Intervention

Professional players: Herbal Hills, Iyengar Yoga Institute, Columbia Nutritional, Nordic Naturals, Helio USA, Yoga Tree, Pure Encapsulations, Inc, Quantum Touch, The Healing Company, John Schumacher?s Unity Woods Yoga Center, Herb Pharm & Deepure Plus

Global Complementary and Alternative Medicine Major Applications/End users: E-Sales & Direct Sales

**The market is valued based on weighted average selling price (WASP) and includes all applicable taxes on manufacturers. All currency conversions used in the creation of this report have been calculated using constant annual average 2020 currency rates.

The Global Complementary and Alternative Medicine is estimated at US$ XX million in 2020 and will reach US$ YY million by the end of 2026, growing at compound annual growth rate of ZZ% during 2021-2026.

Geographical Analysis: Regional and country level analysis integrating the demand and supply forces that are influencing the growth of the market, currently covering North America (Covered in Chapter 6 and 13), United States, Canada, Mexico, Europe (Covered in Chapter 7 and 13), Germany, UK, France, Italy, Spain, Russia, Others, Asia-Pacific (Covered in Chapter 8 and 13), China, Japan, South Korea, Australia, India, Southeast Asia, Others, Middle East and Africa (Covered in Chapter 9 and 13), Saudi Arabia, UAE, Egypt, Nigeria, South Africa, Others, South America (Covered in Chapter 10 and 13), Brazil, Argentina, Columbia, Chile & Others

** For global or regional version of report, list of countries by region are listed below can be provided as part of customization at minimum cost.

North America (United States, Canada & Mexico)Asia-Pacific (Japan, China, India, Southeast Asian Countries & Australia etc)Europe (Germany, UK, France, Italy, Spain, Russia, Netherlands & Belgium etc)Central & South America (Brazil, Argentina, LATAM etc)Middle East & Africa (United Arab Emirates, Qatar, Saudi Arabia, Israel & South Africa etc)

For detailed insights on Global Complementary and Alternative Medicine Market Size, competitive landscape is provided i.e. Revenue Share Analysis (Million USD) by Players (2018-2020), Revenue Market Share (%) by Players (2018-2020) and further a qualitative analysis is made towards market concentration rate, product differentiation, new entrants are also considered in heat map concentration.

Enquire for customization in Report @https://www.htfmarketreport.com/enquiry-before-buy/2999272-global-complementary-and-alternative-medicine-market-report-2020-by-key-players-types-applications-countries-market-size-forecast-to-2026

In this study, the years taken into consideration to estimate the market size of Global Complementary and Alternative Medicine are : History Year: 2015-2020; Base Year: 2020; Forecast Year 2021 to 2026

Key Target Stakeholders Covered in Study:==> Complementary and Alternative Medicine Manufacturers==> Global Complementary and Alternative Medicine Distributors/Traders/Wholesalers==> Complementary and Alternative Medicine Component / Raw Material Producers==> Downstream Vendors

Browse Full Report at @:https://www.htfmarketreport.com/reports/2999272-global-complementary-and-alternative-medicine-market-report-2020-by-key-players-types-applications-countries-market-size-forecast-to-2026

What this Research Study Offers:Global Complementary and Alternative Medicine Market share assessments for the regional or country & business segments (Type) and End UsersMarket share analysis of the industry players highlighting rank, gain in position, % share and segment revenueFeasibility study for the new market entrantsMarket forecasts for a minimum of 6 years of all the mentioned segments, sub-segments, and the regional markets / country level break-upCompany profiling with key strategies, P&L financials, and latest development activitiesMarket Trends (Growth Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and strategic recommendations)Strategic recommendations in major business segments based on the market buzz or voiceCompetitive landscaping & heat map analysis of emerging players with common trendsSupply / value chain trends mapping the latest technological advancements.. and some more..

Actual Numbers & In-Depth Analysis, opportunities of Complementary and Alternative Medicine Market Size Estimation Available in Full Report.

Buy Full Copy Global Complementary and Alternative Medicine Study @https://www.htfmarketreport.com/buy-now?format=1&report=2999272

Thanks for reading full article, contact us at [emailprotected] to better understand detailed research methodology and approach behind this study.

About Author:HTF Market Report is a wholly owned brand of HTF market Intelligence Consulting Private Limited. HTF Market Report global research and market intelligence consulting organization is uniquely positioned to not only identify growth opportunities but to also empower and inspire you to create visionary growth strategies for futures, enabled by our extraordinary depth and breadth of thought leadership, research, tools, events and experience that assist you for making goals into a reality. Our understanding of the interplay between industry convergence, Mega Trends, technologies and market trends provides our clients with new business models and expansion opportunities. We are focused on identifying the Accurate Forecast in every industry we cover so our clients can reap the benefits of being early market entrants and can accomplish their Goals & Objectives.

Contact US :Craig Francis (PR & Marketing Manager)HTF Market Intelligence Consulting Private LimitedUnit No. 429, Parsonage Road Edison, NJNew Jersey USA 08837Phone: +1 (206) 317 1218[emailprotected]

Connect with us atLinkedIn|Facebook|Twitter

Go here to see the original:

Complementary and Alternative Medicine Market to Witness Huge Growth from 2021 to 2027 Cabell Standard - Cabell Standard

HOUSTON, Texas, March 17, 2021 (GLOBE NEWSWIRE) -- via NewMediaWire -- China Infrastructure Construction Corp.(OTC: CHNC)https://www.chnc-hdh.com/:With all hands on deck, and an axiomatically relentless effort to endure and continue to withstand the test of time, CHNC intends to continue to improve its overall performance. And, in addition to its short and long-term promising projects, as well as the need and desire to provide our shareholders andpartnersa great return on their investment; suitably, the board of directors at CHNC by virtue of a cash transaction sealed a buyback of4billion shares, with no dilution effect to shareholders.All the same, shareholders can restassuredwith shrewd knowledge that the ownership of the company that each one hasintheirpossession has not been reducedor diluted. The four billion shares acquired have nowbecome part of the treasury of the company, says Elizabeth Hernandez, COO of CHNC. This move resembles the re-acquisition by a company of its own shares known as a Buyback. Some of you may remember that such transactions used to be deemed as market manipulation, and thats why it was illegal until 1982. After that, buybacks became a frequent practice, and are better used because of different reasons such as ownership consolidation, undervaluation, financial statements, even for compensation purposes (for instance an Employee Stock Option Plan). Among the companies that have performed a buyback we find Apple, Microsoft, Oracle, Berkshire Hathaway, and others. Without a doubt, buybacks have slowly overtaken dividends as a preferred way to increase shareholder value.

On a different note, we continue to nurture and water the collegiate development of our educational training programs aimed at a different public than just consumers/experts of cannabis, whereby, we are now educating doctors, businessmen, legislators, and politicians. Before the present, medical cannabis as a stable business was just a multicolor hallucination, or a political suicide for public office legislators, but with patience and education, cannabis as medication has slowly gained weight and relevance. As an example with accredited educational standards, Colombia, a country with a well-known bloodstained historicalwar on drugs, swiftly took a great step of legalizing cannabis for medical purposes in 2017, gradually changing to be one of the most profitable educational destinations of our franchises and academic venues. Therefore, we are pleased to inform of the novel and renewed alliances made with educational entities such as UTADEO (Universidad Jorge Tadeo Lozano) located in Bgota-Colombia, which for 3 years has collaborated with our firm and featured our educational 12 and 14 weeks Diplomado Curricula, making us pioneers of our Accredited University Diploma Courses, to certified cannabis pedagogical programs in Latin America. It should be noted that these curriculums have had an international reach, with students, health professionals, agronomists, chemists, and patients from countries such as Brazil, Spain, France, Uruguay, Mexico, Peru, USA, and Chile traveling from around the world to Colombia to attend our Diplomados.

Close to the wind, once more we proudly announce our freshest and right out of the oven alliance with the UTB (Universidad Tecnolgica de Bolvar), located in Cartagena Colombia, where we will continue to bet and plant seeds for awareness of cannabis as medicine, research and education.Whats more, we intend to expand our participation to include international exchange programs,as wellasone week summer symposiums with Cannabis leaders-executives from around the world.

If one has ever readOne Hundred Years of Solitude, you will remember that the magical realism of this book, awarded with a Nobel Literature Prize, was inspired by the history of the Caribbean. Hence, given the circumstances, CHNC intends to write a second live oracle edition of the celebrated manuscript, by helpingwrite a page in the history of cannabis in Colombia that will not be tainted or stained with blood, says Anne Graham, In-house Legal Counsel for CHNC. Instead, a scientific story that describes the palliative effects of the flower as medication for the medicinal use of those that have been left behind by traditional medication, in other words out with the opioids in with the cannabinoids, says Dr. Julian Gonzalez, Advisory Board Member of CHNC.Whereby, we can create a new paradigm shift and an introduction to medical therapies, employment and financial opportunities to the magical land ofMacondo.And so, our new academic alliance will commence its history in the cities that inspired the magicalstory; as well Students from all over the world who participate in our diplomas will have the opportunity to visit Cannabis cultivation facilities in Santa Marta, Colombia, (where some of the most recognized cannabis strains in the world originated,ColombianGold), they will also be able to participate in exchanges with already operating cannabis enterprises within the region.

For sure, a lot of progress has taken place in the Latin land, but cannabis goes beyond borders via its transmutation reconstruction and by slowly liberating itself. Be that as it may, the United States is not staying behind in this process, with a 35% increase over 2019, legal medical and adult-use cannabis proceeds that reached the amount of $12.9 billion, and according to statistical outlooks, the sales will hit $20.4 billion by 2022.What is more,with continuedlegalization taking place in parts of the USA, Mexico, and other countries;plus,if we consider the unfortunately still illegal marijuana sales during the last years, we apparently are in front ofindustry revenues inthe vastness of $48.5 billion by 2022, with a quantitative outlook with a pledge promise of a boundless place to be, for a research and educational firm.

Therefore, CHNC reiterates its commitment to the medical cannabis industry, to patients affected by a variety of conditions who seek a natural and efficient alternative to healthcare and to professionals who wish to learn or enhance their knowledge; similarly, to those whose interest was awakened and seek answers to their uneducated present condition.Precisely, this is why we are as pleased as a dog with two tails about the fact that our project "Phytotherapy with cannabinoids for the reduction of symptoms of COVID-19" is presently being sent to executives from different corporations and countries. Our firm is finally beginning to have a life of its own! says Henry Levinski, Treasurer of CHNC. The communiqu that is being sent to some of the most recognized companies, people or funds in the world, can be read at this link https://www.chnc-hdh.com/covid-19.Likewise, for all those interested in knowing who we are sending the Phytotherapy presentation to, can see the list at the following linkhttps://www.chnc-hdh.com/covid-19-contact.

More to the point, please know that our digital publications Cannamed and Cannalaw will soon be enjoying a new sister publication that has been baptized by the name Cannatrade, focusing solely on the up-to-the-minute business aspects of the industry. The cannabis trade is constantly changing; we are surrounded by new businesses, legal challenges and ground-breaking discoveries on a daily basis without any precedent. We understand how overwhelming it can be to keep up with a market that is evolving more and more by the minute and is now an international commerce. Therefore, Cannatrade is attentive to the exciting changes that are stirring the industry such as how is the cannabis stock market, what companies are growing and are attractive to invest, what international businesses are being conducted, what are the alliances that have materialized between countries. With Cannatrade we wish to give the user updated financial information, knowledge on what is out there and how they can by education become part of the speed of light global evolution. For a limited time only, if you would like to apply for an early subscription visit the following linkhttps://www.chnc-hdh.com/canna-trade.

With our new magazine we wish to continue to grow as our currentdigital publicationsthat havepresently reached distribution in an astonishing 70 countries (Andorra, Algeria, Arab Emirates, Argentina, Australia, Austria, Bahrain, Bolivia, Bonaire, Brazil, Cabo Verde, Canada, Chile, Colombia, Costa Rica, Curacao, Czech Republic, Denmark, Dominican Republic, Ecuador, Egypt, El Salvador, Estonia, France, Germany, Guinea, Equatorial Guinea, Greece, Guatemala, Honduras, Iraq, Ireland, Israel, Italy, Ivory Coast, Jamaica, Jordan, Kuwait, Lesotho, Lebanon, Libya, Mexico, Morocco, Malta, Mauritania, Nicaragua, Norway, New Zealand, Palestinian Territories, Panama, Paraguay, Peru, Portugal, Puerto Rico, Qatar, Saudi Arabia, Spain, Syria, Sudan, Sweden, Switzerland, Tunisia, United Kingdom (UK), United States, Uruguay, Venezuela, Yemen and Zambia)... and what is yet to come.

Conclusively, CHNC would like to thank all of our shareholders for their persistent support, inspiration and constant communication that at times for legal reasons we cannot always respond. But be certain that we are here with every intention to victoriously make it to the fourth quarter. Equally important, my gratitude to our front-line partners that tirelessly provide us with their indomitable exertion and support so that we can day by day taste the fruits of our healthy disregard for the impossible. And call to mind that "Every day is an opportunity to innovate and work for global health, from the field of alternative medicine," says Dr. Jose Torres, Director and International Medical Director of CHNC.

Safe Harbor Statement

The information posted in this release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. You can identify these statements by use of the words "may," "will," "should," "plans," "explores," "expects," "anticipates," "continue," "estimate," "projects," "intends," and similar phrases. Forward-looking statements involve risks and uncertainties that could cause actual results to differ from those projected or anticipated. These risks and uncertainties include, but are not limited to, general economic and business conditions, effects of geopolitical conditions, competition, changes in technology and methods of marketing, and various other factors beyond the company's control.

For more information contact us at:

info@pharmacologyuniversity.com

817/528-2475 for English

214/733-0868 for Spanish

View post:

CHNC: Intensity, Determination and a Magical Unwavering Direction Transports CHNC to Become the Macondo of Medical Cannabis Research - GlobeNewswire

When it comes to wellness, the gut is the cornerstone of the overall health and wellbeing of people. However, according to Dr. Saya Pareeth and Dr. Hafeel Ambalath, the founders of The Healers Clinic in Dubai, its a topic that is particularly important, yet is ignored.

With both having extensive experience in holistic care and Ayurvedic treatments, the clinics clear mantra is about healing from the core. In our 20 years together, we have devised innovative protocols in traditional and integrative medicine and have advised people in this arena, the co-founders explain.

In-keeping with the clinics holistic health methods, ensuring the root cause of health issues are dealt with rather than just the symptoms, gut health directly reflects this. Gut health has always been the starting point for age-old health traditions and our practice too, has always been deeply rooted in this concept, they explain.

Dr. Pareeth and Dr. Ambalath sat down withEmirates Womanto discuss their five-year journey with The Healers Clinic, what they focus on and the importance of shining a light on gut health.

One of the challenges was to first understand why we are born on this planet and then are given this huge opportunity to be able to serve people. As a medical professional, often we are overawed with the burden and responsibility placed on us. One of the primary reasons to start The Healers Clinic was to look beyond an okay life and spread the knowledge of traditional medicine, to lead a holistic life. On another level, the rather small number of facilities offering holistic and integrative care was one of the driving forces behind The Healers Clinic.

Our primary aim was to fill the gap between individuals or families and an integrative or holistic family-physician. We wanted to make integrative and holistic care, easily accessible to all who needed it. We also aimed to build awareness in individuals as well as families, on preventive care, rejuvenation, and maintenance of good health, by way of our unique methodologies and practices. And of course, we wanted to see Dubai as a hub of health tourism, where the world got to experience what traditional and alternative medicine can do.

Holistic refers to a complete form of healthcare that does not reject conventional medicine. Instead, it considers a comprehensive and individualized picture of health while using safe, effective and appropriate options for prevention or healing. It involves looking at an individual as a whole, to determine the underlying balances that may affect his or her health.

Speaking of ourselves while we function on the ancient philosophy of preventive health care systems, and practice traditional healing we adapt them and implement them through modern and scientific platforms. We do not restrict ourselves to any one form or method of medical treatment. Incorporating approaches from across the world, we choose a course of treatment best suited to an individuals needs and tailored to individual lifestyles. This briefly describes the holistic approach we have successfully taken, to health and wellness. This also is the beauty of The Healers Clinic as we focus on the overall wellbeing of individuals and on strengthening their core health pillars than indulge in superficial quick fixes.

The bodys gastrointestinal tract and its functions are the cornerstones of our well-being. Numerous studies have shown the connection between our gut health and our immune system, mental health, skin health, endocrine and early points in pathogenesis. Gut health has always been the starting point for age-old health traditions and our practice too has always been deeply rooted in this concept.

It is a large part of discussions doing rounds in health and wellness space because, in simple language, you are talking about a stronger immune system, clearer skin, weight control, hormones, improved state of mind, less bloating, better quality of sleep and improved digestion.

Our gastrointestinal tract is a universe and an ecosystem within us. It is a contained world of complex chemistry and microbes controlled by indefinable energy of intricate movements and messenger systems. The digestive membrane, which makes the walls of this passage and storage space, with little processing units of its own, determines the nature of chemical relations with the outside world of tissues and cells.

In other words, the digestive system decides just what and how much becomes a part of our energy and tissues! A healthy gut reflects not just on your skin but also on your immune system, mood, sleep, digestion, hormonal balance and weight it is the foundation of overall wellbeing.

We would suggest facilitating the body to do what it actually wants to do. We would also suggest reducing pressure on the gut by simplifying the way one treats oneself by eating well and in a healthy manner, getting sufficient sleep, exercising regularly and more. Always listen to the body. Watch what you eat. Watch your day, watch your bowels and your energy levels. Most of the learning happens here. As an integrative and holistic care facility, The Healers Clinic uses age-old, traditional and time-tested eastern ways of understanding the gut with tools and investigations made available by modern western science, such us non-linear health screening. A treatment plan is then designed for an individual.

Vegetables and seasonal fruits are the best. Go slow on grain though. Fish and occasionally, chicken or meat could be a part of your meal plan, but you do not have to consume meat every day. Eating a range of diverse foods that can give rise to new types of bacteria can be beneficial to gut health. Include whole fruits and vegetables that are fibrous and fermented foods like yoghurt, kimchi and sauerkraut.

No single form of treatment or medication can replace proper and healthy eating or lifestyle habits. The Healers Clinic, which is a centre of excellence in integrative and holistic care, encourages people to start on a journey of detox and rejuvenation, wherein we introduce or reinstate healthy gut habits. We take our learning from world cultures and the ancient Ayurveda to introduce cleansing and strengthening gut-health practices. The experience we have gained through our work in the local community, embracing different health cultures it gives us the confidence to say that prevention of disorders and sustenance of good health can be made possible by respecting traditional wisdom along with the modern and scientific understanding. This is what we have made our Vision and our vision is what made us start The Healers Clinic.

We believe that wellness refers to more than just the absence of an ailment. To be precise, it refers to a state of health which is a result of an actively pursued, daily goal. It involves change and therefore growth and is a state of mental, physical and social fitness and stability. We aspire to help people achieve this state! Watch what you eat, when you eat, and how you eat. Avoid overeating and having meals at improper timings. Watch your bowels. The body tells you a lot you need to know. Listen to it.

Images: Supplied

View original post here:

What you need to know about gut health and how it affects your body Emirates Woman - Emirates Woman

Dr. Catherine Claunch is pelted with rain as she walks out into the parking lot. She doesn't have a jacket, because she was in too much of a hurry to speak with her client. As she strides towardthe SUV, the dog inside barks for attention. A veterinarian at Holden Animal Clinic, Claunch has done her fair share of talking about cancer never an easy topic, even when she didnt have to do it in all kinds of weather. She could have called from inside, but she firmly believes there are some things that should be discussed face to face. With COVID restrictions and owners unable to come into the clinic, she goes out to them. She taps on the window before stepping back the requisite six feet.

Vets have never shut down during the pandemic and despite restrictions, they have tried to ensure the same quality of care that they provided before the pandemic. This places them in the category of essential workers who, according to the Centers for Disease Control, provide a range of services for which remote work is not practical. To limit exposure, owners call the front desk upon arrival in the parking lot, staff meet them briefly outside and the patient is handed off. Any other interactions between the clinic staff and owner are done remotely except perhaps in situations like Claunchs. After a year, this has become the new normal for both sides, but familiarity does little to make the system any less cumbersome.

Building trust needs to be done face to face and cannot be done over the phone, said Claunch. Zoom and other video conferencing tools are often not practical due to spotty internet, so the pick-up, drop-offand communication systems have had to be continuously refined balancing safety, efficiency, as well as patient and owner comfort. I try to work with them in whatever way makes them more comfortable, she said, like with speaker phone calls and spending time talking in the parking lot in all kinds of weather, rain and snow.

Thanks to an architectural quirk, Dr. Karen Fine of Central Animal Hospital in Leominster has been able to see her four-legged patients while at the same helping her two legged clients deal with their separation anxiety. Im lucky because my clinic has two exam rooms with windows that clients can look through and see their animal on the table I can open the window to have a conversation, while meeting social distancing guidelines.Even though winter has cut down on this practice, Fine said many still find it easier in some cases to deal with the chilly temperatures than talking on the phone before and after the exam.

While clinic visits may be easier for Fine, COVID restrictions have affected her practice in other ways. Fine practices a holistic approach which integrates both conventional veterinary medicine with alternative treatments such as acupuncture and herbal therapies. I used to leave the dogs with the needles with the owners for 20 minutes while I saw other patients, she explained. Now that clients can no longer come into the clinic, alternative treatments have become much more time consuming, as the pet needs to stay with an assistant. Its just one of all these little logistical things that are affected by the owner not being there, said Fine.

Even though not being physically present is rough for both clients and vets, Claunch is amazed how many pet owners, especially new ones who have never met her face to face, have been willing to work with her on the restrictions. On the whole, people have been very understanding, she said, but we still have pushback from some who say Im not going to bring my animal in if I cant be with them.' These individuals will often ask if she can make an exception, not realizing how many others before them have made this exact same request.

As a small practice of about 15 people, Holden Veterinary Clinic has little room for error. It really just comes down to safety, Claunch said. Were all on top of each other. So if one of us gets sick or exposed, theres a high likelihood it will spread amongst the staff so well have to shut down and then no one gets help. She appreciates that clients have extended their trust, especially since she is a pet parent herself, and knows firsthand about the very special bond between pet owners and veterinarians.

In addition to the trickier logistics of acupuncture, Fine has also had to suspend her 25 year practice of house calls. It was really, really hard to stop back at the beginning when everything was just being canceled, she recalled. It could have been worse, however as COVID struck at something of a transition point in her career. Currently, Fine divides her time between the Leominster clinic for two days a week, where a lot of her house call clients now visit, and writing a textbook on narrative medicine in the veterinary field. She will also be teaching a course on the topic at the Cummings School of Veterinary Medicine at Tufts in Grafton.

Though the window set-up that Fine implemented made clinic visits less stressful on both owners and pets, Fine still receives her share of problematic clients in terms of COVID protocols, especially since the clinic has been busier than ever. When youve been working nonstop with no lunch break or even a bathroom break, its hard when someone gives you attitude when youre just trying to be safe, she said.

There are two primary reasons for the increased caseload. The first is more new animalcompanions being added to families, who now need their check-ups and vaccines. The one bright spot of COVID is that people adopted more animals, said Sheryl Blancato, president and founder of Second Chance Animal Services, an adoption and community veterinary organization.

Another is that remote working people are spending more time with their animals and notice more potential issues. Claunch can readily attest to this for a while, we were so overwhelmed with people bringing current patients that we had to shut down new clients for a while. Everyone was home, paying attention to their animals and noticing things they wouldnt have before.

Everything from breathing funny to finding new lumps on their bodies patients were brought in with symptoms their worried owners had never seen before, if only because they had not been around to observe them until now. One case is a perfect example of both this phenomenon and the occasional absurdity and humor that comes with working in pandemic conditions. Claunch received a call saying a dogs stomach was making wheezing noises. She initially thought it was a respiratory issue but the dog was breathing fine and not making the same noises at the clinic, so the only thing to do was wait until he did. After about 20 minutes, she heard a gurgle. Since the owner wasnt there to identify if this was indeed the sound, Claunch had to call her up and do her best with her vocal chords to imitate the dogs stomach.

Thats how far weve come imitating noises over the phone. Im used to coughing and hairballs but stomach noises were a new one for me, she said laughing, but it turned out the dog had gas. [The owner] was worried since shed never heard this noise before, said Claunch, but when you think about it, the dog probably makes this noise during the 12 hours a day the owners out. A simple probiotic sorted the issue.

In some cases, problems can be caused by more time spent with animals. Claunch has seen more knee injuries in dogs because they are getting so much more playtime, sometimes more than their bodies are used to extended ball or frisbee sessions raising the probability of injury. Adding new clients to the mix opened up a floodgate I think I had five new pets in one day. Three puppies and two kittens and at least three of those were with new pet owners altogether, said Claunch.

As Americans found themselves at home, with their lives seemingly at a standstill, many chose to combat the isolation with a new companion animal. Others found they finally had the time to train and care for that dog or cat they always wanted. Some were first-time owners while others had not had a pet in years both meant new clients for veterinarians across the country.

The animals who share our homes play an important role in supporting our physical and mental wellbeing during the pandemic. Everyone has this different lifestyle [with COVID], so every pet is an emotional support animal right now, said Fine with achuckle.

However, while many days it may feel like life will never return to normal, with the vaccine rollout in full swing, there will come a time when people are no longer at home as much as their pets have grown to expect. So what will be the reaction of pets who have known nothing but the round the clock company of their owners?

I am extremely worried about separation anxiety when people go back to work, Claunch admitted. She strongly recommended that both new and experienced owners begin practicing now for that eventuality, though admitted its hard to not want to spend every possible minute with an eight-week-old puppy.

Fine agrees that return to work routines, home renovation, or kids going back to college can stress animals, dogs especially. She recounted an incident where a family dog had been vomiting, not acting like himself and going into his crate to rest. The owner was surprised when Fine said it was more emotional than anything else the sudden departure of a family member was a major disruption in the dogs routine, with the stress manifesting in physical symptoms.Not only was the dog missing the boy, Fine said, but he was also likely reacting to the mothers stress over her son returning to college. When we get stressed, they get stressed. Were more like dogs now, and change is a little harder for us.

Regarding easing into post-COVID life, Fine agrees with Claunch. Im a fan of crate training because it keeps them safe and keeps your house safe, she said. Sherecommends making the crate a really fun place such as using a reward they dont get anywhere else be it a special toy or particularly tasty treat (she personally uses baby carrots cooked in chicken broth).

All that being said, both vets agree that its still not a bad time to get a puppy as there is more time than ever to focus on essential behavior training. Work with their paws every day, practice brushing teeth, Claunch encouraged. All those things that you used to run out of time for during the day. Teaching the sit and stay commands are especially important and will pay dividends when homes start receiving visitors again, so a dogs enthusiastic greeting doesnt cause problems."

Throughout the pandemic, the primary concern of most veterinarians has been how to maintain smooth, uninterrupted communications with their clients. For instance, if Claunch finds a new lump, she can turn to the owner and ask "have you seen this, how long has it been there, can I evaluate this further?"and so on. Instead, I have to finish the exam and take notes to review, then call the owner about the lump, ask about more testing, run the tests; so its much more of a piecemeal feeling and doesnt have the smooth flow that we used to have.

Owners are also looking for an alternative to current clinic protocols and Dr. Cindy McGinn offers one. If pet owners cant come into the vet clinic, the vet will come to them. McGinn runs Homecare Veterinary Service in Worcester, and travels to the homes of clients in neighboring towns. Her practice has been excessively busy since the pandemic began with clients calling on her, when they could not accompany their animals into other clinics. Were a small business and cant afford to just stop so we never did, said McGinn.

Initially, McGinn had appointments outdoors but in the cold weather, she had to go inside homes. People didnt want to do curbside care, but being inside their homes, she has to constantly remind people to keep their masks on. She recounted how she struggled with emotional burnout when she received calls for euthanasia because owners did not want to hand their pet over at the door, wanting to be with them at the end.McGinn said, its a stressful job when your patients need you and you cant be there for them when you want to be.

Weve realized how much our animals mean to us, observed Claunch. I think we sort of knew but didnt quite know just how important until we had people taken away during the shutdowns. Theres nothing like going home on a hard day for me and having a little snuggle. Unfortunately, with the economic fallout of the pandemic, many people have had to give up the emotional lifeline provided by pets, being unable to keep them due to job loss or having to pay for their own healthcare.

All animals provide emotional support, saidBlancato. To that end, Second Chance Animal Services offers subsidized veterinary care at their three, soon to be four, different animal hospitals. Like other operations, Second Chance has seen a marked increase in clients since COVID. Blancato said numbers have been two to three times higher than usual, requiring them to hire more vets and techs. The initial months of the pandemic were the hardest, as supplies (personal protective equipment and medicine) became hard to come by.

After about six to eight weeks, things started to ease back, she said, and Second Chance began to find its feet, focusing on under-resourced areas and providing access to vet care so people could keep their pets during the time they needed them most. However, to do this safely required them to get creative.

Second Chance proved they could do that when they adapted their existing mobile vet service, which offered free vaccines for pets in low-income areas. It was extremely popular and could attract as many as 400 people at a time. However, under pandemic circumstances, social distancing was impossible. Rather than suspend it, Blancato said they implemented a pre-registration protocol where people chose time windows to maintain social distancing and when we go back out this year, were going to keep using that. It helped streamline the system, staff love it and people dont have to stand in line for hours.

While it is clear that we need veterinarians to be creative and keep doing what they do for us, it is a heavy lift and they put themselves and their staff at risk. In terms of vaccination priority, veterinarian status varies by state. In California, they were included in phase one, along with other healthcare workers. In Massachusetts, they are listed under phase three with the general public.

Honestly, its really upsetting, said Claunch, Out of all of the industries in this state and all the places that are essential services, we have never stopped. Holden Veterinary Clinic has not taken even one day off from COVID-related causes. While they have been able to limit exposure through rigorous safety and cleaning protocols, the constant stress added to their regular work takes a toll. I feel very strongly that we are providing an essential service, said Claunch.

While the state vet association has been working to raise their priority, Fine agrees that the current situation is frustrating. We are in close contact with both the public and with each other, she said. There is no question for her that the vaccine would help everything go smoother and safer.

So next time you take your companion to the vet, and want to grumble about the hand-off ritual and phone calls from the parking lot, bear in mind that you and your pet do this once. Were doing this 20 to 40 times a day, said Claunch.

Everyone Fine knows is exhausted as well. Were doing the best we can," she said,"but between the vaccine and spring coming up, theres light at the end of the tunnel.

Blancato agrees that things have come a long way and the outlook is brighter now. When this first started, I didnt know what we were going to do. Everybody was in panic mode at the beginning and worried for themselves and their families, but we were inventive and were able to continue when others couldnt. So proud of my staff now.

More:

Dogged determination: Central Mass. veterinarians on the front lines of COVID - Worcester Mag

SOUTH SAN FRANCISCO, Calif., March 18, 2021 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasdaq: CYTK) today announced that data from a secondary analysis of GALACTIC-HF (Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure) assessing the effect of omecamtiv mecarbil on clinical outcomes in relationship to patient baseline ejection fraction will be presented in a Late Breaking Clinical Trial session at the American College of Cardiology 70th Annual Scientific Session & Expo (ACC.21) by John Teerlink, M.D., Professor of Medicine, University of California San Francisco, Director of Heart Failure, San Francisco Veterans Affairs Medical Center and Executive Committee Chair, GALACTIC-HF.

Title: 410-16 Impact Of Ejection Fraction On The Therapeutic Effect Of Omecamtiv Mecarbil In Patients With Heart Failure And Reduced Ejection Fraction: A Secondary Analysis From GALACTIC-HF (Global Approach To Lowering Adverse Cardiac Outcomes Through Improving Contractility In Heart Failure)Presenter: John Teerlink, M.D., Professor of Medicine, University of California San Francisco, Director of Heart Failure, San Francisco Veterans Affairs Medical Center and Executive Committee Chair, GALACTIC-HFDate: May 17, 2021Session Title: Late-Breaking Clinical Trials IVSession Time: 8:00 9:15 AM ETPresentation Time: 9:00 9:10 AM ET

About Cytokinetics

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised and/or declining. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact muscle function and contractility. Cytokinetics is preparing for regulatory interactions for omecamtiv mecarbil, its novel cardiac muscle activator, following positive results from GALACTIC-HF, a large, international Phase 3 clinical trial in patients with heart failure. Cytokinetics is conducting METEORIC-HF, a second Phase 3 clinical trial of omecamtiv mecarbil. Cytokinetics is also developing CK-274, a next-generation cardiac myosin inhibitor, for the potential treatment of hypertrophic cardiomyopathies (HCM). Cytokinetics is conducting REDWOOD-HCM, a Phase 2 clinical trial of CK-274 in patients with obstructive HCM. Cytokinetics is also developing reldesemtiv, a fast skeletal muscle troponin activator for the potential treatment of ALS and other neuromuscular indications following conduct of FORTITUDE-ALS and other Phase 2 clinical trials. The company is preparing for the potential advancement of reldesemtiv to a Phase 3 clinical trial in ALS. Cytokinetics continues its over 20-year history of pioneering innovation in muscle biology and related pharmacology focused to diseases of muscle dysfunction and conditions of muscle weakness.

For additional information about Cytokinetics, visit http://www.cytokinetics.com and follow us on Twitter, LinkedIn, Facebook and YouTube.

Forward-Looking Statements

This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). Cytokinetics disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act's Safe Harbor for forward-looking statements. Examples of such statements include, but are not limited to, statements relating to the GALACTIC-HF clinical trial, statements indicating that the actual top-line results of the GALACTIC-HF clinical trial will be available or presented at the Late Breaking Clinical Trial session at the American Heart Association (AHA) Scientific Sessions 2020 or at any other specific time or event; statements relating to the METEORIC-HF clinical trial; the potential benefits of omecamtiv mecarbil, including its ability to represent a novel therapeutic strategy to increase cardiac muscle function and restore cardiac performance; the timing and likelihood of any regulatory submissions or approval of omecamtiv mecarbil, Cytokinetics' and its partners' research and development activities; the design, timing, results, significance and utility of preclinical and clinical results; and the properties and potential benefits of Cytokinetics' other drug candidates. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, potential difficulties or delays in the development, testing, regulatory approvals for trial commencement, progression or product sale or manufacturing, or production of Cytokinetics' drug candidates that could slow or prevent clinical development or product approval; Cytokinetics' drug candidates may have adverse side effects or inadequate therapeutic efficacy; the FDA or foreign regulatory agencies may delay or limit Cytokinetics' or its partners' ability to conduct clinical trials; Cytokinetics may be unable to obtain or maintain patent or trade secret protection for its intellectual property; the nature of Amgen's decisions with respect to the design, initiation, conduct, timing and continuation of development activities for omecamtiv mecarbil; standards of care may change, rendering Cytokinetics' drug candidates obsolete; competitive products or alternative therapies may be developed by others for the treatment of indications Cytokinetics' drug candidates and potential drug candidates may target; and risks and uncertainties relating to the timing and receipt of payments from its partners, including milestones and royalties on future potential product sales under Cytokinetics' collaboration agreements with such partners. For further information regarding these and other risks related to Cytokinetics' business, investors should consult Cytokinetics' filings with the Securities and Exchange Commission.

Contact:CytokineticsDiane WeiserSenior Vice President, Corporate Communications, Investor Relations(415) 290-7757

More:

Cytokinetics Announces Secondary Analysis From GALACTIC-HF to Be Presented in Late Breaking Clinical Trial Session at American College of Cardiology...