Sprott, R. L. Biomarkers of aging and disease: introduction and definitions. Exp. Gerontol. 45, 24 (2010).
CAS PubMed Google Scholar
Bell, C. G. et al. DNA methylation aging clocks: challenges and recommendations. Genome Biol. 20, 249 (2019).
PubMed PubMed Central Google Scholar
Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371384 (2018).
CAS PubMed Google Scholar
Schultz, M. B. et al. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nat. Commun. 11, 4618 (2020).
CAS PubMed PubMed Central Google Scholar
Bobrov, E. et al. PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging. Aging 10, 32493259 (2018).
PubMed PubMed Central Google Scholar
Lehallier, B. et al. Undulating changes in human plasma proteome profiles across the lifespan. Nat. Med. 25, 18431850 (2019).
CAS PubMed PubMed Central Google Scholar
Fleischer, J. G. et al. Predicting age from the transcriptome of human dermal fibroblasts. Genome Biol. 19, 221 (2018).
CAS PubMed PubMed Central Google Scholar
Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, R115 (2013).
PubMed PubMed Central Google Scholar
Hannum, G. et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol. Cell 49, 359367 (2013).
CAS PubMed Google Scholar
Levine, M. E. et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging 10, 573591 (2018).
PubMed PubMed Central Google Scholar
Petkovich, D. A. et al. Using DNA methylation profiling to evaluate biological age and longevity interventions. Cell Metab. 25, 954960 (2017).
CAS PubMed PubMed Central Google Scholar
Meer, M. V., Podolskiy, D. I., Tyshkovskiy, A. & Gladyshev, V. N. A whole lifespan mouse multi-tissue DNA methylation clock. eLife 7, e40675 (2018).
PubMed PubMed Central Google Scholar
Thompson, M. J. et al. A multi-tissue full lifespan epigenetic clock for mice. Aging 10, 28322854 (2018).
CAS PubMed PubMed Central Google Scholar
Levine, M. et al. A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin. eLife 9, e59201 (2020).
CAS PubMed PubMed Central Google Scholar
Robeck, T. R. et al. Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins. Commun. Biol. 4, 642 (2021).
CAS PubMed PubMed Central Google Scholar
Wilkinson, G. S. et al. DNA methylation predicts age and provides insight into exceptional longevity of bats. Nat. Commun. 12, 1615 (2021).
CAS PubMed PubMed Central Google Scholar
Wang, T. et al. Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment. Genome Biol. 18, 57 (2017).
PubMed PubMed Central Google Scholar
Horvath, S. et al. Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies. Aging 10, 17581775 (2018).
CAS PubMed PubMed Central Google Scholar
Lu, Y. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124129 (2020).
CAS PubMed PubMed Central Google Scholar
Kerepesi, C., Zhang, B., Lee, S.-G., Trapp, A. & Gladyshev, V. N. Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Sci. Adv. 7, eabg6082 (2021).
CAS PubMed PubMed Central Google Scholar
Lu, A. T. et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging 11, 303327 (2019).
CAS PubMed PubMed Central Google Scholar
Pidsley, R. et al. Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biol. 17, 208 (2016).
PubMed PubMed Central Google Scholar
Meissner, A. et al. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res. 33, 58685877 (2005).
CAS PubMed PubMed Central Google Scholar
Han, Y. et al. Epigenetic age-predictor for mice based on three CpG sites. eLife 7, e37462 (2018).
PubMed PubMed Central Google Scholar
Han, Y. et al. New targeted approaches for epigenetic age predictions. BMC Biol. 18, 71 (2020).
CAS PubMed PubMed Central Google Scholar
Han, Y. et al. Targeted methods for epigenetic age predictions in mice. Sci. Rep. 10, 22439 (2020).
CAS PubMed PubMed Central Google Scholar
Wang, T. et al. Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome. Cell Syst. 11, 176185 (2020).
PubMed PubMed Central Google Scholar
Wendt, J., Rosenbaum, H., Richmond, T. A., Jeddeloh, J. A. & Burgess, D. L. Targeted bisulfite sequencing using the SeqCap Epi enrichment system. Methods Mol. Biol. 1708, 383405 (2018).
CAS PubMed Google Scholar
Mulqueen, R. M. et al. Highly scalable generation of DNA methylation profiles in single cells. Nat. Biotechnol. 36, 428431 (2018).
CAS PubMed PubMed Central Google Scholar
Rohland, N. & Reich, D. Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture. Genome Res. 22, 939946 (2012).
CAS PubMed PubMed Central Google Scholar
Wang, M. & Lemos, B. Ribosomal DNA harbors an evolutionarily conserved clock of biological aging. Genome Res. 29, 325333 (2019).
CAS PubMed PubMed Central Google Scholar
Zullo, J. M. et al. Regulation of lifespan by neural excitation and REST. Nature 574, 359364 (2019).
CAS PubMed PubMed Central Google Scholar
Whitehead, J. C. et al. A clinical frailty index in aging mice: comparisons with frailty index data in humans. J Gerontol. A 69, 621632 (2014).
Google Scholar
Watada, E. et al. Age-dependent ribosomal DNA variations in mice. Mol. Cell. Biol. 40, e00368-20 (2020).
CAS PubMed PubMed Central Google Scholar
Rodriguez-Algarra, F. et al. Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states. Genome Biol. 23, 54 (2022).
CAS PubMed PubMed Central Google Scholar
Seligman, B. J., Berry, S. D., Lipsitz, L. A., Travison, T. G. & Kiel, D. P. Epigenetic age acceleration and change in frailty in MOBILIZE Boston. J. Gerontol. A 77, 17601765 (2022).
CAS Google Scholar
Zhou, W. et al. DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse. Cell Genom. 2, 100144 (2022).
CAS PubMed PubMed Central Google Scholar
Lee, M. B., Hill, C. M., Bitto, A. & Kaeberlein, M. Antiaging diets: separating fact from fiction. Science 374, eabe7365 (2021).
CAS PubMed PubMed Central Google Scholar
Baur, J. A. et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337342 (2006).
CAS PubMed PubMed Central Google Scholar
Ocampo, A. et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 167, 17191733 (2016).
CAS PubMed PubMed Central Google Scholar
Gill, D. et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. eLife 11, e71624 (2022).
CAS PubMed PubMed Central Google Scholar
Matsuyama, M., WuWong, D. J., Horvath, S. & Matsuyama, S. Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT. Aging 11, 30123022 (2019).
CAS PubMed PubMed Central Google Scholar
Matsuyama, M. et al. Analysis of epigenetic aging in vivo and in vitro: factors controlling the speed and direction. Exp. Biol. Med. 245, 15431551 (2020).
CAS Google Scholar
Liu, Z. et al. Underlying features of epigenetic aging clocks in vivo and in vitro. Aging Cell 19, e13229 (2020).
CAS PubMed PubMed Central Google Scholar
Gu, H. et al. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat. Protoc. 6, 468481 (2011).
CAS PubMed Google Scholar
Lehallier, B., Shokhirev, M. N., Wyss-Coray, T. & Johnson, A. A. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging. Aging Cell 19, e13256 (2020).
CAS PubMed PubMed Central Google Scholar
Bruinsma, S. et al. Bead-linked transposomes enable a normalization-free workflow for NGS library preparation. BMC Genomics 19, 722 (2018).
PubMed PubMed Central Google Scholar
Mulqueen, R. M. et al. High-content single-cell combinatorial indexing. Nat. Biotechnol. 39, 15741580 (2021).
CAS PubMed PubMed Central Google Scholar
Nguyen Ba, A. N. et al. Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast. eLife 11, e73983 (2022).
PubMed PubMed Central Google Scholar
Krueger, F. & Andrews, S. R. Bismark: a flexible aligner and methylation caller for bisulfite-seq applications. Bioinformatics 27, 15711572 (2011).
CAS PubMed PubMed Central Google Scholar
The rest is here:
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction - Nature.com
- DNA Tests and Stranded Bodies: Ukraine's Struggle to Name Its Dead - The New York Times - May 5th, 2024 [May 5th, 2024]
- Study highlights the role of dynamic DNA structures in memory consolidation - News-Medical.Net - May 5th, 2024 [May 5th, 2024]
- Two identical-looking athletes with same name get DNA test to see if they are long-lost siblings - UNILAD - May 5th, 2024 [May 5th, 2024]
- Patitz Awarded NSF Grant for Research on DNA-Based Nanostructure Research - University of Arkansas Newswire - May 5th, 2024 [May 5th, 2024]
- DNA on bandana leads to arrest of suspect in 2010 Indiana County robbery case - WTAE Pittsburgh - May 5th, 2024 [May 5th, 2024]
- DNA recovered from wine bottle leads to arrest of burglary suspect - WGN TV Chicago - May 5th, 2024 [May 5th, 2024]
- Junk DNA from Three Perspectives: Some Key Quotes - Discovery Institute - May 5th, 2024 [May 5th, 2024]
- Flipons: The discovery of Z-DNA and soft-wired genomes - Open Access Government - May 5th, 2024 [May 5th, 2024]
- New DNA evidence leads to arrest in 1984 cold case homicide of Everett woman - KING5.com - May 5th, 2024 [May 5th, 2024]
- Ancient DNA Reveals Kinship Structure of Eurasia's Avars - Archaeology Magazine - May 5th, 2024 [May 5th, 2024]
- Water bottle, DNA, fingerprints led to arrest of Chicago police officer Luis Huesca's accused killer, police say - CBS Chicago - May 5th, 2024 [May 5th, 2024]
- Jason Licht: Part of the DNA of this football team is trying to prove everybody wrong - NBC Sports - May 5th, 2024 [May 5th, 2024]
- New DNA evidence found in connection with 2014 Georgia murders of Shirley and Russell Dermond - GPB News - May 5th, 2024 [May 5th, 2024]
- Unraveling the roles of non-coding DNA explains childhood cancer's resistance to chemotherapy - Medical Xpress - May 5th, 2024 [May 5th, 2024]
- South Carolina's 'In Our DNA SC' aims for 100k participants in diverse health research - ABC NEWS 4 - May 5th, 2024 [May 5th, 2024]
- Joel Embiid finally discovers he has the DNA of a champion. Down 2-1, can he lead the Sixers past the Knicks? - The Philadelphia Inquirer - April 27th, 2024 [April 27th, 2024]
- Unraveling DNA's role in pop culturefrom superheroes to crime scenes - The Daily | Case Western Reserve University - April 27th, 2024 [April 27th, 2024]
- Elucidation of inhibitory effects of bioactive anthraquinones towards formation of DNA advanced glycation end products ... - ScienceDirect.com - April 27th, 2024 [April 27th, 2024]
- DNA Testing Proved My Innocence of My Son's Murder - Innocence Project - April 27th, 2024 [April 27th, 2024]
- Generative A.I. Arrives in the Gene Editing World of CRISPR - The New York Times - April 27th, 2024 [April 27th, 2024]
- Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure - Nature.com - April 27th, 2024 [April 27th, 2024]
- Enhanced CRISPR method enables stable insertion of large genes into the DNA of higher plants - Phys.org - April 27th, 2024 [April 27th, 2024]
- Scientists inspired the right guardrails for nuclear energy, the internet, and DNA research. Let them do the same for AI - Fortune - April 27th, 2024 [April 27th, 2024]
- Test your dog's DNA to learn about their heritage and health for only $120 - New York Post - April 27th, 2024 [April 27th, 2024]
- Earth Life Biodiversity: Vast DNA Tree Of life For Flowering Plants Revealed - Astrobiology - Astrobiology News - April 27th, 2024 [April 27th, 2024]
- Katie Holmes and Suri Cruise Share Some Very Stylish DNA - Vogue - April 27th, 2024 [April 27th, 2024]
- DNA evidence leads to arrest of 75-year-old Auburn man - Opelika Auburn News - April 27th, 2024 [April 27th, 2024]
- Putnam NY cold case: DNA test finds skeleton is not Robin Murphy's - The Journal News - April 27th, 2024 [April 27th, 2024]
- Ancient nomads you've probably never heard of disappeared from Europe 1,000 years ago. Now, DNA analysis ... - The Conversation - April 27th, 2024 [April 27th, 2024]
- Genetics Studies Have a Diversity Problem That Researchers Struggle To Fix - Kaiser Health News - April 27th, 2024 [April 27th, 2024]
- Keeping Telomeres in Their Places - The Scientist - April 27th, 2024 [April 27th, 2024]
- WWII veteran Ward Thomas identified through genealogy testing - 10TV - April 27th, 2024 [April 27th, 2024]
- Vast DNA tree of life for plants revealed by global science team using 1.8 billion letters of genetic code - Phys.org - April 27th, 2024 [April 27th, 2024]
- Here is a look at one of the labs that helped uncover new DNA evidence in Lake Oconee murder - WSB Atlanta - April 27th, 2024 [April 27th, 2024]
- This Guardians prospect has baseball in his DNA - 1330 WFIN - April 27th, 2024 [April 27th, 2024]
- DNA identifies last known remains of victims of notorious Green River Killer, cops say - Miami Herald - January 23rd, 2024 [January 23rd, 2024]
- UNE to study why rare lobsters have strange-colored shells - Spectrum News - January 23rd, 2024 [January 23rd, 2024]
- DNA evidence identifies last known victim of Green River Killer almost 40 years later - NBC Right Now - January 23rd, 2024 [January 23rd, 2024]
- New bill would give California parents more control over whether state can store their kid's DNA - CBS News - January 23rd, 2024 [January 23rd, 2024]
- Lucas County Sheriff's Office doing advanced testing on DNA found at site of 2011 Clarke and Straub murders - WTOL - January 23rd, 2024 [January 23rd, 2024]
- Last known remains connected to the Green River Killer identified through DNA | WTGS - Fox28 Savannah - January 23rd, 2024 [January 23rd, 2024]
- 5 Best Ancestry DNA Tests 2024 To Help You Learn More About Your Health - GLAMOUR UK - January 23rd, 2024 [January 23rd, 2024]
- 11 Investigates: Lucas County Sheriff's Office doing advanced testing on DNA found at site of 2011 Clarke and Straub murders - WTOL - January 23rd, 2024 [January 23rd, 2024]
- Researchers improve blood tests' ability to detect and monitor cancer - MIT News - January 23rd, 2024 [January 23rd, 2024]
- DNA test approved for Duxbury's Lindsay Clancy, who is accused of killing her 3 children - The Patriot Ledger - January 23rd, 2024 [January 23rd, 2024]
- 1,650th victim of 9/11 identified through advanced DNA testing - FOX 17 West Michigan News - January 23rd, 2024 [January 23rd, 2024]
- We Think Cavco Industries (NASDAQ:CVCO) Might Have The DNA Of A Multi-Bagger - Yahoo Finance - January 23rd, 2024 [January 23rd, 2024]
- DNA From the Ocean's 'Twilight Zone' Could Lead to New Lifesaving Drugs, Scientists Say - Smithsonian Magazine - January 23rd, 2024 [January 23rd, 2024]
- Last known remains connected to the Green River Killer identified through DNA - KOMO News - January 23rd, 2024 [January 23rd, 2024]
- 9/11 victim identified as John Ballantine Niven of Oyster Bay with help of DNA technology - WABC-TV - January 23rd, 2024 [January 23rd, 2024]
- Scott Peterson has every right to DNA test: Attorney from case - NewsNation Now - January 23rd, 2024 [January 23rd, 2024]
- DNA from stone age chewing gum sheds light on diet and disease in Scandinavia's ancient hunter-gatherers - The Conversation - January 23rd, 2024 [January 23rd, 2024]
- Barbara Lee responds to Nikki Haley: Racism is in the DNA of this country - The Hill - January 23rd, 2024 [January 23rd, 2024]
- DB Cooper 'will finally be identified' after 53 years due to huge DNA breakthrough - LADbible - January 23rd, 2024 [January 23rd, 2024]
- Dog Owners Who Abandon Poops To Be Found Using DNA Tests in Italy - Newsweek - January 23rd, 2024 [January 23rd, 2024]
- Scientists gather bobcat DNA from paw prints - KJZZ - January 16th, 2024 [January 16th, 2024]
- Discovering Fusions Requires More Than DNA Testing in GI Cancers - OncLive - January 16th, 2024 [January 16th, 2024]
- Largest-ever ocean DNA study uncovers mysteries of marine life - Earth.com - January 16th, 2024 [January 16th, 2024]
- 1st-ever ancient case of Turner syndrome, with just 1 X chromosome instead of 2, found in ancient DNA - Livescience.com - January 16th, 2024 [January 16th, 2024]
- Minnesota Mother Calls on NYS to Allow DNA Testing Finger Lakes Daily News - Finger Lakes Daily News - January 16th, 2024 [January 16th, 2024]
- DNA Didn't Match Marcellus Williams. Missouri May Fast-Track Execution Anyway. - The Intercept - January 16th, 2024 [January 16th, 2024]
- Ancient DNA From Eurasian Herders Sheds Light on the Origins of Multiple Sclerosis - Smithsonian Magazine - January 16th, 2024 [January 16th, 2024]
- DNA's hotel toh kuyabeh mirrors bird flight undulations in tulum - Designboom - January 16th, 2024 [January 16th, 2024]
- Research into ancient DNA sheds new light on cause of Multiple Sclerosis and other neurodegenerative diseases - University of Oxford - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe - University of Cambridge news - January 16th, 2024 [January 16th, 2024]
- Gilgo Serial Killer Suspect Rex Heuermann Tied to Slaying by DNA From Daughter's Can of Coffee: Prosecutors - The Messenger - January 16th, 2024 [January 16th, 2024]
- DNA evidence leads to arrest of Denton sexual assault suspect - The Cross Timbers Gazette - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high multiple sclerosis and Alzheimer's rates in Europe - EurekAlert - January 16th, 2024 [January 16th, 2024]
- New technique identifies earliest cases of genetic disorders from ancient DNA - University of Oxford - January 16th, 2024 [January 16th, 2024]
- Ancient DNA could be hiding all kinds of health secrets - Deccan Herald - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe - ScienceBlog.com - January 16th, 2024 [January 16th, 2024]
- Supreme Court seeks government's view on DNA profiling of unidentified bodies - IndiaTimes - January 16th, 2024 [January 16th, 2024]
- Prosecution Ordered to Release Portion of DNA Evidence to Kohberger's Defense Team - bigcountrynewsconnection.com - January 16th, 2024 [January 16th, 2024]
- Judge orders more DNA disclosure in University of Idaho murder case - KXLY Spokane - January 16th, 2024 [January 16th, 2024]
- Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining ... - Nature.com - December 14th, 2023 [December 14th, 2023]
- The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection - Nature.com - December 14th, 2023 [December 14th, 2023]
- How an immune response is driven by one letter difference in DNA - Medical Xpress - December 14th, 2023 [December 14th, 2023]
- Tracy Morgan Discovered He Was Related to Nas After DNA Test - PEOPLE - December 14th, 2023 [December 14th, 2023]
- Scientists testify about DNA in third week of Aguirre trial - The Spokesman Review - December 14th, 2023 [December 14th, 2023]
- DNA metabarcoding focusing on the plankton community: an effective approach to reconstruct the paleo-environment ... - Nature.com - December 14th, 2023 [December 14th, 2023]