Monthly Archives: August 2022

The U.S. Food and Drug Administration (FDA) approved Zoryve (roflumilast) cream 0.3 percent for the treatment of plaque psoriasis, including intertriginous areas (where skin rubs against other skin) in people 12 years of age and older, according to a press release issued by Arcutis, the manufacturer of the drug. Once-daily Zoryve is the first and only approved topical phosphodiesterase-4 (PDE4) inhibitor, the first and only FDA-approved steroid-free cream in its class.

PDE4 inhibitors suppress the immune system by reducing the action of an overactive enzyme (phosphodiesterase 4), thereby reducing inflammation.

It is always great to have another topical option to treat psoriasis, so this approval is exciting, says Marisa Garshick, MD, a board-certified dermatologist at MDCS Dermatology in New York City. Zoryve will be a good choice for those patients who prefer to avoid a topical steroid, she adds.

This approval offers yet another steroid-free option for people with plaque psoriasis; in May, the FDA approved Vtama (tapinarof) cream 1 percent for topical treatment of mild, moderate, or severe plaque psoriasis in adults.

FDA approval is based on data from two phase 3 randomized, double-blind, vehicle-controlled (Zoryve was compared to a placebo or dummy cream) trials that included a total of 881 people, called the DERMIS1 and DERMIS2 studies, presented at the 2021 Clinical Dermatology Conference in Las Vegas, Nevada.

The primary endpoint wasInvestigator Global Assessment (IGA)success, defined as clear or almost clear skin with at least a 2-grade improvement from baseline, and at least a 2-grade IGA score improvement from baseline at eight weeks. In the 2 trials, 42.4 percent and 37.5 percent of the patients treated with Zoryve achieved an IGA success rate, compared with 6.1 percent and 6.9 percent in the control groups, respectively.

Nearly 3 in 4 people (73.5 percent) completed 52 to 64 weeks of treatment, and fewer than 1 percent of participants discontinued because the medication didn't work.

In addition to clearing the skin, Zoryve improved the severity and impact of itch. Of participants with a Worst Itch-Numerical Rating Score (WI-NRS) of 4 or higher at baseline, 2 out of 3 people using Zoryve achieved at least a 4-point reduction at week 8. The WI-NRS is a questionnaire that asks patients to rate their itch from 0 (no itch) to 10 (worst imaginable itch) in the past 24 hours, according to an article published October 23, 2021, in BMC Health and Quality of Life Outcomes.

While topical steroids are a very effective option for psoriasis, their use over time should be limited, says Dr. Garshick. There are certain locations on the body, including the face and skin folds, where their use should be limited to prevent thinning of the skin, she adds.

Zoryve is the only topical that has data specifically focusing on the treatment of intertriginous plaques (those found in skin folds), said Frank Watanabe, the president and CEO of Arcutis, in the statement. For people who have psoriasis in those areas, which can include areas such as the underarms, under the breasts, or the groin area, Zoryve can be a safe and effective option, says Garshick.

Unlike steroids, there is no restriction on how long Zoryve can be used to treat plaque psoriasis, according to the approval statement. When used chronically (over a long period of time), topical steroids can cause stretch marks in areas like the thighs or the armpits, according to the American Academy of Dermatology (AAD).

In general, Zoryve is safe and easy to tolerate for those with psoriasis, says Garshick. The most commonly reported side effects in people using Zoryve were diarrhea (3.1 percent), headache (2.4 percent), insomnia (1.4 percent), nausea (1.2 percent), application site pain (1 percent), upper respiratory tract infection (1 percent), and urinary tract infection (1 percent).

The current wholesale acquisition cost (WAC) pricing is $825 for a 60 gram (g) tube of Zoryve, according toArcutis. The actual cost to the patient will depend on insurance coverage.

The company offers a savings program; people with commercial insurance that provides Zoryve coverage will pay $25 a tube, and those with commercial insurance that does not cover Zoryve will pay $75 a tube. Financially eligible patients who dont have insurance or who are underinsured may access the cream through the Arcutis Cares Patient Assistance Program.

Excerpt from:
FDA Approves New Treatment for People With Plaque Psoriasis - Everyday Health

Bri Morrell from Leicester was diagnosed with psoriasis, an irritating skin condition which causes red, scaly patches to appear on her skin

Image: mediadrumimages/@thatgirlpatches)

A woman who says 70 percent of her body is covered in red marks has opened up about having psoriasis.

Bri Morrell from Leicester was diagnosed with the irritating condition, which causes red, scaly patches to appear on her skin, earlier this year.

The customer service advisor believes the condition was triggered after suffering a period of depression.

Psoriasis causes the skin cells to grow at a rapid rate, with new skin cells growing every three days, instead of at a one-month rate.

As a result, there is an excess of skin cells that pile up on the surface, causing inflammation, swelling and redness.

These patches cover nearly 70 per cent of Bri's body, causing itching, soreness and in some cases bleeding when her skin splits open.

Psoriasis affects every inch of Bri's body. It doesn't just affect her bare skin, but also her scalp and even her fingernails and toenails.

To ease the psoriasis and irritation, Bri wears baggy and loose-fitting clothes, lessening her contact to tight-fitting materials.

Bri's psoriasis started in her early 20s, slowly appearing before taking over her body.

Image:

Image:

She believes it was triggered by a low period of her life when Bri suffered a period of depression.

Psoriasis can be brought on by stress, depression, or changes in hormones, as well as many other things.

Despite visiting the doctors, Bri says she didn't receive any treatment for her skin.

She was offered an immune-suppressing drug, however, she turned down the treatment due to the multitude of harsh side effects that accompany the drugs.

Instead, to manage the irritation, Bri uses a cream which reduces the soreness and dryness of the skin.

Bri wants to inspire others, using her Instagram as a platform to spread body positivity to others and reduce the stigma around the skin disease.

Image:

Image:

"I never got psoriasis until I was in my early twenties," said Bri.

"There isn't one part of my body it doesn't affect.

"I have it on my scalp, face, back, chest, stomach, legs, toes, hands, nails.

"Around seventy percent of my body is covered.

"It was triggered by a low period in my life.

"My condition can cause me low periods, but that's generally when other things are bothering me, and the psoriasis is like a straw that broke the camel's back.

Image:

Image:

"I find the itchiness and flakiness the most annoying part.

"It can be embarrassing when it's in my scalp or ears as I worry people may think it's down to me not washing my hair.

"When I'm not using my cream, I struggle to get about as my skin is so sore and literally splits open, but I used the regularly which helps control my psoriasis."

Bri says she has had to change her attitudes and has spoken about the amazing support she has had in place through her journey.

Image:

Image:

"I've had to overcome caring what people think and learn to love myself despite not fitting into European beauty standards," she said.

"I've always been very fortunate to date understanding people who not only accept my psoriasis, but actually find it attractive as they say it's different and unique.

"If I dated a guy who was embarrassed or irritated by my skin then he wouldn't last long.

"My family is extremely supportive of my skin and have helped me to embrace it, as well as my ex-partner.

"I've never received hate online, but I have had funny stares from people before.

"I think there is a lack of education on skin conditions, so a lot of the time people don't know what they're dealing with."

Bri hopes to educate people about psoriasis and help people accept their individual beauty, regardless of their skin.

"I was confident enough to embrace it," said Bri.

"I'm proud of the fact that I embrace my skin and have helped others to feel less embarrassed about having a skin condition.

"I'm proud of building my Instagram with content that I've been told by others has inspired them not to hide their own skin.

"I think it's important to learn to love yourself so much that something like a skin condition won't get you down.

"Stop comparing yourself to other people on social media. I am really bad for that, and it's never done me any good. Ever since I stopped, I've felt so much better within myself."

Read More

Read More

Continued here:
Woman says 70% of her body is covered in red marks due to rare condition - The Mirror

Country

United States of AmericaUS Virgin IslandsUnited States Minor Outlying IslandsCanadaMexico, United Mexican StatesBahamas, Commonwealth of theCuba, Republic ofDominican RepublicHaiti, Republic ofJamaicaAfghanistanAlbania, People's Socialist Republic ofAlgeria, People's Democratic Republic ofAmerican SamoaAndorra, Principality ofAngola, Republic ofAnguillaAntarctica (the territory South of 60 deg S)Antigua and BarbudaArgentina, Argentine RepublicArmeniaArubaAustralia, Commonwealth ofAustria, Republic ofAzerbaijan, Republic ofBahrain, Kingdom ofBangladesh, People's Republic ofBarbadosBelarusBelgium, Kingdom ofBelizeBenin, People's Republic ofBermudaBhutan, Kingdom ofBolivia, Republic ofBosnia and HerzegovinaBotswana, Republic ofBouvet Island (Bouvetoya)Brazil, Federative Republic ofBritish Indian Ocean Territory (Chagos Archipelago)British Virgin IslandsBrunei DarussalamBulgaria, People's Republic ofBurkina FasoBurundi, Republic ofCambodia, Kingdom ofCameroon, United Republic ofCape Verde, Republic ofCayman IslandsCentral African RepublicChad, Republic ofChile, Republic ofChina, People's Republic ofChristmas IslandCocos (Keeling) IslandsColombia, Republic ofComoros, Union of theCongo, Democratic Republic ofCongo, People's Republic ofCook IslandsCosta Rica, Republic ofCote D'Ivoire, Ivory Coast, Republic of theCyprus, Republic ofCzech RepublicDenmark, Kingdom ofDjibouti, Republic ofDominica, Commonwealth ofEcuador, Republic ofEgypt, Arab Republic ofEl Salvador, Republic ofEquatorial Guinea, Republic ofEritreaEstoniaEthiopiaFaeroe IslandsFalkland Islands (Malvinas)Fiji, Republic of the Fiji IslandsFinland, Republic ofFrance, French RepublicFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabon, Gabonese RepublicGambia, Republic of theGeorgiaGermanyGhana, Republic ofGibraltarGreece, Hellenic RepublicGreenlandGrenadaGuadaloupeGuamGuatemala, Republic ofGuinea, RevolutionaryPeople's Rep'c ofGuinea-Bissau, Republic ofGuyana, Republic ofHeard and McDonald IslandsHoly See (Vatican City State)Honduras, Republic ofHong Kong, Special Administrative Region of ChinaHrvatska (Croatia)Hungary, Hungarian People's RepublicIceland, Republic ofIndia, Republic ofIndonesia, Republic ofIran, Islamic Republic ofIraq, Republic ofIrelandIsrael, State ofItaly, Italian RepublicJapanJordan, Hashemite Kingdom ofKazakhstan, Republic ofKenya, Republic ofKiribati, Republic ofKorea, Democratic People's Republic ofKorea, Republic ofKuwait, State ofKyrgyz RepublicLao People's Democratic RepublicLatviaLebanon, Lebanese RepublicLesotho, Kingdom ofLiberia, Republic ofLibyan Arab JamahiriyaLiechtenstein, Principality ofLithuaniaLuxembourg, Grand Duchy ofMacao, Special Administrative Region of ChinaMacedonia, the former Yugoslav Republic ofMadagascar, Republic ofMalawi, Republic ofMalaysiaMaldives, Republic ofMali, Republic ofMalta, Republic ofMarshall IslandsMartiniqueMauritania, Islamic Republic ofMauritiusMayotteMicronesia, Federated States ofMoldova, Republic ofMonaco, Principality ofMongolia, Mongolian People's RepublicMontserratMorocco, Kingdom ofMozambique, People's Republic ofMyanmarNamibiaNauru, Republic ofNepal, Kingdom ofNetherlands AntillesNetherlands, Kingdom of theNew CaledoniaNew ZealandNicaragua, Republic ofNiger, Republic of theNigeria, Federal Republic ofNiue, Republic ofNorfolk IslandNorthern Mariana IslandsNorway, Kingdom ofOman, Sultanate ofPakistan, Islamic Republic ofPalauPalestinian Territory, OccupiedPanama, Republic ofPapua New GuineaParaguay, Republic ofPeru, Republic ofPhilippines, Republic of thePitcairn IslandPoland, Polish People's RepublicPortugal, Portuguese RepublicPuerto RicoQatar, State ofReunionRomania, Socialist Republic ofRussian FederationRwanda, Rwandese RepublicSamoa, Independent State ofSan Marino, Republic ofSao Tome and Principe, Democratic Republic ofSaudi Arabia, Kingdom ofSenegal, Republic ofSerbia and MontenegroSeychelles, Republic ofSierra Leone, Republic ofSingapore, Republic ofSlovakia (Slovak Republic)SloveniaSolomon IslandsSomalia, Somali RepublicSouth Africa, Republic ofSouth Georgia and the South Sandwich IslandsSpain, Spanish StateSri Lanka, Democratic Socialist Republic ofSt. HelenaSt. Kitts and NevisSt. LuciaSt. Pierre and MiquelonSt. Vincent and the GrenadinesSudan, Democratic Republic of theSuriname, Republic ofSvalbard & Jan Mayen IslandsSwaziland, Kingdom ofSweden, Kingdom ofSwitzerland, Swiss ConfederationSyrian Arab RepublicTaiwan, Province of ChinaTajikistanTanzania, United Republic ofThailand, Kingdom ofTimor-Leste, Democratic Republic ofTogo, Togolese RepublicTokelau (Tokelau Islands)Tonga, Kingdom ofTrinidad and Tobago, Republic ofTunisia, Republic ofTurkey, Republic ofTurkmenistanTurks and Caicos IslandsTuvaluUganda, Republic ofUkraineUnited Arab EmiratesUnited Kingdom of Great Britain & N. IrelandUruguay, Eastern Republic ofUzbekistanVanuatuVenezuela, Bolivarian Republic ofViet Nam, Socialist Republic ofWallis and Futuna IslandsWestern SaharaYemenZambia, Republic ofZimbabwe

Continue reading here:
Spending time in the sun can be good for eczema or psoriasis, but doctors say don't overdo it - Your News Now

KIM Kardashian has shown off her real skin texture in her daughter North's latest TikTok.

The reality star, 41, displayed her visible pores and psoriasis in a video the nine-year-old shared on Sunday.

5

5

5

Kim, 41, posted a new clip over the weekend to the TikTok account she shares with her eldest daughter.

In the video, the preteen gave her famous mom a very distinctive makeover.

At the start of the clip, Kim's pores could be seen on her cheeks as well as pink patches on her neck from psoriasis.

Psoriasis is a skin condition that causes flaky patches of skin which can look pink or red.

North gave her mom the full Minions treatment complete with yellow face paint, purple lips, and black lines around her eyes to resemble the characters famous goggles.

Kim added the text Mommy Minion, to describe the finished result.

The Keeping Up With the Kardashians-alum has previously revealed that North loves makeup and special FX, so its no surprise that she has to volunteer as a model sometimes.

North is one of four children that Kim shares with Kanye, along with Saint, six, Chicago, four, and Psalm, three.

Kanye has said in the past that he is not happy with his daughter being on TikTok, although the account is managed by an adult.

But the new video comes amid fan rumors that Kim and Kanye might have rekindled their relationship.

Many fans believe that a number of clues recently suggest that Kim and Kanye have reconciled.

On Friday, Kim took to her Instagram Stories to post a photo ofNorth modeling a pair of Yeezy sunglasses designed by her rapper dad.

Similarly,Kris Jennerwas spotted on Wednesdaywearing a pair of Yeezy sneakerswhile preparing for a Christmas photoshoot withKhloe Kardashian.

But thats not all.

Kim posted on social media earlier this week to reveal that she waswatching The Truman Show, which the Donda star has previously said is one of his favorite movies.

It came after she had alsoshared an image from American artist James Turrell, whom Kanye has previously collaborated with.

The dad-of-four was recently spotted looking so happy as he took North to her basketball game with Chicago.

Meanwhile, Kims new boyfriend Pete Davidson wasspotted looking downcastin Australia this week, where he is away filming a movie.

The actor will now be away from Kim for even longer than he had planned because his new movie, Wizards, has suffered a delay in production.

Kim hadtraveled to Australiaearlier this month to spend time with her beau, who has a busy work schedule just like her.

Things appear to have to been going well between the two in recent months, with Pete even hinting that hewould like to get married and have childrenwith the Hulu star.

5

5

We pay for your stories!

Do you have a story for The US Sun team?

Go here to read the rest:
Kim Kardashians daughter North, 9, shocks fans by showing off moms REAL skin including pores and pso... - The US Sun