Daily Archives: August 23, 2022

Trauma in Your DNA: Educator of the Year Lecture – Psychiatric Times

Posted: August 23, 2022 at 1:10 am

Can we inherit our parents trauma? Research points to yes.

CONFERENCE REPORTER

Real true, posttraumatic stress disorder [PTSD] is going to have an impact, certainly on the next generation and maybe generations after that, said Rachel Yehuda, PhD.

Yehuda, in the Educator of the Year Lecture at the 2022 Annual Psychiatric Times World CME Conference in San Diego, shared her research on the potential of PTSD being passed genetically through the generations. Studying the Holocaust and 9/11 survivors showed fascinating results.

At a clinic for Holocaust survivors and their families at Mount Sinai School of Medicine, families reported feeling damaged, guilty, anxious, full of morbid grief, and had dysfunctional interpersonal relationships due to fear of loss. Overall, the children of survivors believed that parental Holocaust exposure was involved in their current mental health problems.

Previous research by Yehuda et al showed adult offspring of Holocaust survivors had differential effects of maternal and paternal PTSD in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. With both maternal and paternal PTSD, offspring had lower GR-1F promoter methylation; with just paternal PTSD, offspring had GR-1F promoter hypermethylation.1 Furthermore, Holocaust exposure induced intergenerational effects on FKBP5 methylation; specifically, Holocaust survivors and their adult children showed a nongenotype dependent change in methylation compared to their respective controls.2 This was the first demonstration of an association of preconception parental trauma with epigenetic alterations that is evident in both exposed parent and offspring.

Similar findings resulted from Yehudas work on the effects on 9/11. For example, in a post-9/11 program surveilling women who were pregnant, Yehuda and researchers collected salivary cortisol from mothers and babies.3 What we found is that the mothers that felt PTSD, their cortisol levels were lower, but its also lower in babies, which was really wild, said Yehuda. But heres the kicker: Both cortisol levels are lowest in the babies of mothers with PTSD who were exposed in the third trimester.

This research suggests maternal PTSD may confer additional in utero effects, causing more anxiety for example.3 Trauma exposure during pregnancy directly affects the fetus and fetus germ cells, Yehuda shared.3

How does trauma pass down? Yehuda explained that epigenetic changes could survive cell division associated with the formation of sperm and eggs; if the parent is exposed to trauma, their exposure could result in epigenetic changes that may affect their sperm or eggmeaning a single trauma could simultaneously affect multiple generations without direct exposure.

This is inherited in our DNA, said Yehuda. Trauma is inherited.

The biological remnants of parental experiences in our DNA can affect us in multiple ways, according to Yehuda. They can influence our response to stressors/challenges, make us better able to detect and respond to threats, increase vulnerability to mental health disorders, and increase our attunement to injustice. They are enduring, but not irreversible, Yehuda stressed.

References

1. Yehuda R, Daskalakis NP, Lehrner A, et al. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. Am J Psychiatry. 2014;171(8):872-880.

2. Yehuda R, Daskalakis NP, Bierer LM, et al. Holocaust exposure induced intergenerational effects on FKBP5 methylation. Biol Psychiatry. 2016;80(5):372-380.

3. Yehuda R, Engel SM, Brand SR, et al. Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy. J Clin Endocrinol Metab. 2005;90(7):4115-4118.

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Trauma in Your DNA: Educator of the Year Lecture - Psychiatric Times

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30 Years in Microbial Manufacturing of Plasmid DNA, Vaccines, and Proteins – BioProcess Insider

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Richter-Helm BioLogics is a first-in-class biopharmaceutical CDMO with strong quality and customer focus. With 30 years of experience manufacturing microbially derived products including product classes such as therapeutic proteins and peptides, antibody formats (e.g., VHH nanobodies), bacterial vaccines, and plasmid DNA (pDNA) the company has gained first-hand knowledge that can be applied easily to individual customer projects. That positions it as a preferred and experienced partner, especially for plasmid DNA projects.

Over the past few decades, Richter-Helm has developed from a small biotechnology company into a leading contract development and manufacturing organization (CDMO) with a strong focus on customer needs, timelines, and quality requirements. It was one of the first CDMO players in pDNA production 30 years ago. Always on the cutting edge in a constantly developing market, the company implemented a number of production processes for protein- and pDNA-based projects and developed in-house Pichia-based production processes.

The demand for current good manufacturing practice (CGMP)-compliant pDNA has grown over the years and led to Richter-Helms development of its proprietary, high-performance RHB-pART pDNA platform. The technology efficiently delivers pDNA products from 10-L to 1,000-L scales. Typically, the 200-L scale process leads to yields of 520 g, and yields of >100 g can be obtained at the 1,000-L scale. The final result is always a high-quality pure plasmid confirmed using high-resolution analytics. Currently operating three different production processes, Richter-Helm accommodates several product classes for different applications.

Trends in Microbial BiotechnologyContinuous growth of the biopharmaceutical industry and its need for flexible manufacturing solutions are ongoing trends driven by expanding numbers of drug candidates and strong interest in bringing such products to the market quickly. The COVID-19 pandemic has made those needs even more evident. The industry must react to such rapidly evolving diseases immediately to preserve human health and save millions of lives. These trends are likely to continue.

Local and regional shutdowns affected delivery of equipment and consumables throughout the CDMO landscape. Masks, cleanroom equipment, and disinfectants were in short supply, for example. With a warehouse of needed materials and high company-wide motivation to keep manufacturing, Richter-Helm lost no batches to such delays.

All biopharmaceutical products need to be produced at defined quality and quantities within set timelines. Candidates compete for limited production capacity around the world. Biomanufacturing takes place in highly complex multiproduct facilities, with capacities limited by the realities of a growing market that were exacerbated during the pandemic. As a result, the CDMO industry is growing and expanding its capacities as quickly as possible to compensate for the lack of biomanufacturing capacity. Richter-Helm currently operates two GMP-compliant production plants with bioreactor capacities of 1,000-L working volume, enabling manufacture of phase 13 clinical materials and commercial supplies. By adding two more bioreactors with capacities of 200 L and 1,000 L working volumes for microbial production, the company is reacting to the needs of the market.

Growth in the microbial manufacturing field is considered to be particularly strong, and the range of products it can make is expanding. Plasmid DNA and other product classes can be obtained from microbial sources: therapeutic proteins, peptides, some antibody formats, and bacterial vaccines. Such products can be used either directly as therapeutic agents (drug substances) or further processed into even more complex drug products.

One of the most important developments has been catalyzed by the COVID-19 pandemic. The new field of messenger RNA (mRNA) vaccines was developing rapidly already and now has achieved its first product approvals. This has moved pDNA production more into the focus of global interest and increased demand for microbial manufacturing processes.

In general, pDNA can be seen as the key to establishing new and life-changing therapeutic approaches. Plasmids are produced as critical raw materials for further processing and to serve as starting material for mRNA, treatments based on RNA interference (RNAi), cell and gene therapies, virus production, and cell-free expression systems. The pandemic certainly has increased demand for pDNA supplies. DNA plasmids also can be drug substances and vaccines, themselves. Over the near term, pDNA should realize its greatest growth in demand from late clinical trials into commercial applications, with the most potential in cell and gene therapy applications.

Different processes are used at different scales for different purposes. Plasmid products especially require an established and highly sensitive analytical platform, including a generic and validated quality control (QC) testing approach, as is in place at Richter-Helm. The companys versatile analytical concept contains procedures to determine quickly and accurately not only pDNA content, but all other relevant quality parameters (e.g., isoforms and purity). For time-critical projects, this provides a reliable way to speed progress to clinical testing or to market.

Timely supply of pDNA of needed qualities and quantities is the main focus of Richter-Helm, which uses an established analytical platform for pDNA products that includes generic and validated quality testing. A high-quality purification with high concentrations and maintenance of supercoiled pDNA (>95%) is achieved. That provides a reliable way to enable fast time-to-clinic or -market for time-critical projects. The companys high quality standards have been verified regularly by numerous customer audits as well as detailed inspections by major regulatory bodies: e.g., the European Medicines Agency (EMA), US Food and Drug Administration (FDA), Japans Pharmaceuticals and Medical Devices Agency (PMDA), Brazils Agncia Nacional de Vigilncia Sanitria (ANVISA), South Koreas Ministry of Food and Drug Safety (MFDS), and more.

Organic Growth Through Technological AdvancementOver the past 2030 years, microbial biotechnologies have represented a side niche of the CDMO industry. But because of ongoing developments in new therapeutic approaches such as mRNA, gene therapies, and chimeric antigen receptor (CAR) T-cell therapies, the pDNA market has experienced significant growth. Richter-Helm is contributing to the progress of major achievements through its rich history and unique knowledge base, its flexibility, and the high-quality GMP production it can offer. Expansion of the business comes through operations rather than mergers and acquisitions. The company plans to continue expanding its capacity over the long term and further offer reliable and highly specialized CDMO services to support the global pharmaceutical and biotechnological industries.

Thilo Kamphausen, PhD, is director of business development at Richter-Helm BioLogics GmbH & Co. KG, Suhrenkamp 59, 22335 Hamburg, Germany; 49-4331-1230-451; t.kamphausen@richter-helm-biologics.eu; https://www.linkedin.com/company/richter-helm-biologics. Kai Pohlmeyer, PhD, is managing director; 49-40-55290-430; k.pohlmeyer@richter-helm-biologics.eu.

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Harm’s Way (band) – Wikipedia

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American hardcore punk band

Harm's Way[N 1] is an American straight edge hardcore punk band from Chicago, Illinois, formed in 2006. The band started as a side project, but ended up becoming a more serious and full-time band in their later years. Harm's Way has since released four studio albums: Reality Approaches (2009), Isolation (2011) and Rust (2015) and several EPs. On February 9, 2018, the band released their critically acclaimed Metal Blade Records debut, titled Posthuman. They have been recognized for their unique blend of metal, industrial, and hardcore music.

In 2006,[5] the members of a straight edge punk band called Few and the Proud started a "side project-slash-joke"[1] band to have fun playing short-and-fast powerviolence songs influenced by Crossed Out and Infest.[6] Harm's Way drummer Chris Mills commented on the band's early days and progression, stating: "We'd play super fast powerviolence songs, and our singer would put on a mask and sing silly lyrics about beating up frat boys or whatever. Then, later as the band became more serious, we retired a lot of those elements and went in a more death metal directiondarker and less ridiculous, even if some aspects of it still weren't 100 percent serious."[1] Harm's Way released several albums, EPs and singles through Organized Crime Records and Closed Casket Activities in their early days.

After the release of their 2011 second studio album Isolation, Harm's Way emailed Jacob Bannon (Converge) and his label Deathwish Inc. after hearing that he was a fan of the band's music to ask if the label would be interested in signing them.[5] The band's signing to Deathwish was announced in March 2013.[7] Harm's Way released the EP Blinded on July 23, 2013 featuring artwork by Florian Bertmer,[5] and promoted it with a music video for the track "Mind Control" followed by a world tour.[7][8] Mills commented on their positive relationship with the label, stating: "It's been awesomethey've been really helpful, we have a bigger budget, we were able to do a music video. They've been willing to do anything we've really wanted. They're really supportive."[5] The Blinded EP also saw the band incorporating more Godflesh-influenced industrial metal into their sound.[5][9]

Harm's Way released its third studio album Rust through Deathwish on March 10, 2015 and promoted it with a music video for the track "Amongst the Rust."[10][11] Commenting on the band's musical and imagery changes with Rust, Mills said: "We're still locked into these niches in people's mindsyou know, meathead tough guy hardcore band, Satan-worshipping death metal band, whatever. We see Rust as not just a new musical phasewe're changing up the old logo and taking a different direction with the imagery to try to steer people away from generalizations and assumptions based on stuff that really doesn't represent who we are as people or musicians."[1] The album was met with generally positive reviews. Writing for Rock Sound, Chris Hidden gave the album an eight-out-of-ten, and said: "This new record finds them in formidable form, with the likes of 'Amongst The Rust' and 'Cancerous Ways' blending the down-tuned riff attack of nu metal with groove-led thrash and the crushing intensity of hardcore to produce a sound that references everyone from Sepultura to Trapped Under Ice."[12] Harm's Way began touring in support of Rust with a March/April 2015 North American tour with Code Orange and others, a May/June European tour, the European leg of Deathwish Fest and US headlining tour in July, and touring North American with The Black Dahlia Murder in October.[11][13][14][15]

On 6 December 2017, the band announced their fourth studio album, and Metal Blade Records debut, titled Posthuman. The record was set for release on 9 February 2018, and was produced by Will Putney at Graphic Nature Audio.[16] After the album release and a FebruaryMarch US tour, Luca Cimarusti wrote for the Chicago Reader, "...theyve finally fully realized their fascination with [Godflesh]. ...Posthuman is one of the darkest, heaviest records youll hear this year."[17] A year later, Harm's Way released a four-song EP titled PSTHMN featuring industrial remixes of songs from Posthuman.[18]

The band's musical style has been described as hardcore punk,[3][19][20] metalcore[21] industrial metal,[citation needed] industrial,[3] and death metal.[3] The band's early work has been described as powerviolence.[22][19] They also incorporate elements of groove metal,[20] industrial,[20] death metal, black metal, and nu metal into their sound.[23] The band's music has been compared to bands like Code Orange,[24] Slipknot,[25] and Godflesh.[20]

Current members

Former members

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Timothy Alberino – Author, Explorer, Filmmaker

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The Coming Posthuman Apocalypse and the Usurpation of Adam's Dominion on Planet Earth

Known as the modern-day Indiana Jones, Timothy Alberino is a consummate explorer. His inquisitive mind and insatiable appetite for adventure have led him all over the planet in search of lost cities, lost civilizations, hidden treasures, and legendary creatures. He is also an avid researcher and published author whose scholarly pursuits are as daring as his expeditions. After years of rigorous study, Alberino has garnered an expansive knowledge base that enables him to dissertate with authority on a wide variety of esoteric topics, including theories on alternative history; ancient mythologies, megalithic architecture; giants, Bigfoot, and other cryptids; UFOs and alien abduction; transhumanism and emerging technologies; occult conspiracy; and Christian eschatology.

The earth and distant extraterrestrial worlds are reeling in the wake of war and ruin. A powerful insubordinate prince, personified as thedragon, thedevil, and thesatan, has mounted an unsuccessful insurrection against the kingdom of heaven in a battle of unimaginable destruction. The planets in our solar system, once teeming with life, have been laid waste and left to careen in their orbitstohu va-bohudesolate and empty. After untold eons of inundated oblivion, the time has finally come to restore the terrestrial realm and appoint a new regent to govern itAdam, the first man.

This is the preamble to the story of mankind. The offspring of Adam have forgotten who they are. Now faced with extinction at the hands of an alien adversary, it is time for them to remember.

In this revolutionary book, Timothy Alberino retraces the pages and reveals the secrets of the greatest story ever told, the one in which we are all inescapably embroiled. From the galactic rebellion in the pre-Adamic past to the creation of mankind on Planet Earth; the fall of the watchers in the pre-Flood world to the machinations of Luciferian forces in modern times; the unveiling of the alien presence to the final battle at Armageddon; Alberino unpacks the synchronicity of these events with scholarly precision and leaves you breathless on the brink of a posthuman apocalypse.

Lecture Series in English

Lecture Series in Spanish

Join Timothy Alberino and the GenSix Productions film crew as they head to the High Andean Plain (Altiplano) of Peru and Bolivia on the shores of legendary Lake Titicaca in search of evidence of the Watchers, their giant offspring, and the technology of the fallen.

Was there high technology in the forgotten world before the Flood of Noah? Who were the true builders of the megaliths? Why is there a deliberate conspiracy to conceal their origins? Discover the answers to these questions in True Legends: Technology of the Fallen!

Are the forbidden secrets of the prehistoric past linked to the forthcoming events of the prophetic future? Is there a hidden hand confiscating and concealing artifacts relating to the world before the Flood of Noah and the hybrid entities that inhabited it? Are living giants still walking the earth today? Is the Vatican preparing for the arrival of alien saviors? In this fast-paced episode, Steve Quayle, Timothy Alberino and Tom Horn unveil the surprising answers to these compelling questions.

An ancient conspiracy has been quietly burgeoning behind the bustle of the modern world. From the mounds of America, to the megalithic ruins on the island of Sardinia in the Mediterranean Sea, the desiccated bones of dead giants are being systematically disentombed and secreted away to clandestine vaults for apocalyptic purposes. While occultists are attempting to harness the arcane necromancy of the Canaanites, genetic engineers are working feverishly to reconstitute the genomes of the giants, and resurrect the dreaded race of Rephaim in the earth.

Subscribe to the e-mailing list to receive updates from Timothy Alberino regarding his current projects, public expeditions, conference appearances, radio interviews, and YouTube video publications. This is the best way to continue to track with Timothy if he is banned from social media.

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The Writing Seminars | Princeton Writing Program

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Each year, the Princeton Writing Program offers over 100 Writing Seminars of 12 students each on a wide variety of topics, from Your Life in Numbers and The Politics of Nostalgia to Contagion and The Posthuman. Student voices are at the center of each Writing Seminar community, where they practice not only how to write, but how to become generous and rigorous readers of each others work. In this way writing is understood as critical thinking that can be radically deepened and clarified through a process of feedback and revision.

First-year Writing Seminars are multidisciplinary and designed to emphasize transferable skills in critical inquiry, argument, and research methods. Every first-year student completes a Writing Seminar to fulfill the University writing requirement.

The practices, knowledge, and strategies to which students are introduced in their First-year Writing Seminars serve as a foundation for their ongoing development as sophomores, juniors, and seniors, guided by faculty across the university.

Additional seminars are sometimes offered in collaboration with departments for students beginning work in their concentrations to hone their research and writing skills in the discipline.

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The Writing Seminars | Princeton Writing Program

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Five Brilliant Books of Aussie Spec Fic – tor.com

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I grew up watching Doctor Who, Star Wars, and reading Spec Fic. Anything I could get my hands on, if it had a dragon on the cover or a spaceship, I was there. Which back in those days (the Eighties) meant books from the UK or the US. When I discovered that there were people writing Spec Fic in Australia, it blew my mind. It made me think that maybe I could have a crack at it as well.

Australian Spec Fic was extremely hard to find growing up in the Eighties, but these days its everywhere, and its weird and wild and wonderful. Here are five of my favourites, old and new.

This world first collection of all Aboriginal and Torres Strait Islander writers is incredible. Editor Mykaela Saunders is a Lebanese and Koori writer, of Dharug descent, and she has gathered together a truly impressive anthology of stories. This is a retrospective as well as a showcase of new writers including Alexis Wright, Evelyn Araleun, John Morrissey, Hannah Donnelly, and Samuel Wagan Watson. The depth and breadth of stories here is stunning. There are hauntings, pandemics, AIs, and hurt your-guts-with-laughter satire in these pages

This All Come Back Now sits at the heart of a wave of First Nations Spec Fic and is as important and vital as Dangerous Visions was for the New Wave in the late sixties.

Were just at the beginning of the beginning of addressing the great problems and inequities of this country stolen from the oldest storytelling cultures on earth. These stories are an incredible, wild, and angry ride, and I loved every one of them.

I dont think you can talk about contemporary Australian Spec Fic without talking about Claire G. Coleman. A Noongar woman who has charged onto the science fiction and literary scene. Her stories dont hold back their punches, and why should they?

Perhaps the biggest fantasy to come out of Australia is Australia itself. Terra Nullius tackles the lie at the heart of colonial Australia: that the island continent belonged to no-one and was an uncontested land. Of course, it wasnt (and remains so), but that we need to constantly be reminded of this shows how all-pervasive this mind-set is.

What begins as a classic tale of Settlers, and subjugated Natives, becomes something very different. The hot dry land that Clair Coleman depicts isnt at all what we think it is. Ive had people tell me this isnt SF, but thats only because they havent hit the moment when everything changes. The story twists and turns, and along the way it works the great magic of SF, bringing us the shock of the world were living in now. Like J.G Ballard once said: Earth is the alien planet.

If you want to understand contemporary Australia, or the notion of Australia as an insidious fiction, Claire Colemans work is a great place to start, and she has a new Spec Fic book out called Enclave. You cant go wrong with any of her writing.

Ghost Bird is a YA horror thriller, and a powerful depiction of growing up in a small, dusty country town. While not strictly Spec Fic, using depictions of slightly-altered traditional creatures to avoid misappropriation, it will appeal very much to Spec Fic readers. It has truly scary monsters, and some of the worst of them are people. The book is masterful in its evocation of place. The landscape lives and breathes. We feel its menace, and anger at trespass, as a visceral thing. The dream sequences in this book are heart in your throat great, and I dont think I have looked at a tawny frogmouth (the ghost bird of the title) quite the same ever since.

When Staceys twin sister Laney goes missing its up to Stacey to find her, navigating a world of terrifying dreams and mystery. Its one of the best books I have read in the last few years. A story of community and secrets. The book pulls you in from the start and it doesnt let up.

Lisa is a Wuilli woman from Eidsvold, Queensland, also descended from Wakka Wakka and Gooreng Gooreng nations. She also has a short story in This All Come Back Now.

I love her work, not least because it gets me looking under the couch just in case something is hiding in the shadows.

Margo Lanagan writes the most beautiful prose and uses it to describe the darkest of places.

Tender Morsels is a magical, powerful book about pain and healing, and motherhood and sisters, and boys turning into bears. Margo reworks fairy tales and makes them her own, her characters sing and grumble in utterly striking and unique voices that are, still, strangely familiar. This story riffs off the tale of Snow White and Rose Red, and its the kind of no-nonsense but wildly beautiful telling of a classic tale remade that is endlessly appealing.

It is arguably one of the great works of Australian Fantasy, and Margo one of our greatest writers. Her short story Singing My Sister Down still makes me cry when I think about it.

Theres been quite a bit of novel-length Urban Fantasy written about Brisbane (Ive even dabbled), but not so much science fiction. This is pure and tricksy science fiction. We follow the life of Liv through a series of five novellas, each exploring the impact of technology on sexuality, while the world heats and changes in the background. There is a VR suit that flips the story of two lovers, a consciousness uploaded into jellyfish, a synthetic child, and even a journey into love in a posthuman world.

Its dark in places, and confronting, but Krissy is too clever and their touch too light to make it grim. Krissys novels often skirt the line between realism and spec fic, but this remains my favourite.

It ends in a moment of warmth and transcendence that takes it to the upper level of books that explore not just what it is to be human, but what it is to live post-humanly (hmm, is that even a word?).

Its a genuine Science Fiction classic.

***

Of course, we have many other fine writers in Australia including Greg Egan, Sean Williams, Ellen van Neerven, Shelley Parker-Chan (the first Australian to be shortlisted for a Hugo for best novel), Angela Slatter, Ben Peek, Freya Marske, James Bradley, Alan Baxter, Marianne de Pierres, Tansy Rayner Roberts, Rowena Cory Daniells, Kathleen Jennings, Shaun Tan, Kaaron Warren, Cat Sparks, Grace Dugan, and I could go on.

Unlike those early days of my reading, if youve a hankering to check out some Australian Spec Fic youre spoiled for choice, I reckon.

Trent Jamieson is a multi-award winning Australian novelist and short story writer. He is the author of The Stone Road, the Death Works series, and the Nightbound Land duology. When hes not writing, Trent works as a bookseller at Avid Reader in Brisbane.

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Elon Musk Spells Out 2 ‘Giant Kahunas’ He Hopes To Accomplish In 2022: ‘Will Require Insane Work By Many – Benzinga

Posted: at 1:08 am

The task is cut out for Tesla, Inc. TSLACEO Elon Musksteam, with the billionaire himself outlining the focus areas for the remainder of the year.

What Happened: The orbital launch of SpaceXs Starship reusable spacecraft and the wider release of Teslas full-self-driving software are the main goals for this year, Musk said on Twitter early Monday.

Although many other things are in the pipeline, these are the two giant kahunas, he said.

Will require insane work by many super talented people, but, if anyone can do it, they can, he said in a pep talk directed apparently at his employees. He also commended his workforce and said it is an honor to work with such awesome human beings."

Musk said in a separate tweet that the Neuralink progress update show & tell is scheduled for Oct. 31.

Separately, the entrepreneur expressed a wishto have a simplified Hyperloop demo tunnel between Austin, where Tesla is now headquartered, to San Antonino.

It is the fastest way to get between one downtown and another with known physics (and the Standard Model is proving quite resilient)1, he said.

See also:Do You Want To Work With Elon Musk? Here's What Over 55% Of Benzinga's Twitter Followers Said

Why Its Important: Musk announced Sunday a 25% bump up in the price of FSD, which is currently in beta testing. The price hike to $15,000 would take effect on Sept. 5 and this would mark the second upward adjustment for the year.

The FSD is seen by analysts as a major revenue earner for Tesla in the mid-to-long term.

Musk had said in early August that the Starship, which is being developed and tested at SpaceXs Boca Chica, Texas facility, will likely have a successful orbital flight between one and 12 months. The Starship is meant to transport both crew and cargo to the Earths orbit, the Moon, and Mars. NASA has chosen Starship for its Moon mission and Musk also harbors an ambitious goal of using the spacecraft to transport humans to Mars in a bid to make life multi-planetary.

Price Action:In premarket trading, Tesla shares were plunging 2.05% to $890, according to Benzinga Pro data.

Photo by Daniel Oberhaus via Flickr

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Elon Musk actually lives in tiny 37k house as he jokes about buying Man United – The Mirror

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Elon Musk captures the persona of an eccentric billionaire rather well, with the Tesla CEO recently admitting to living in a tiny $45,000 (37,000) home next to his rocket factory

Image: Getty Images)

Elon Musk recently opened up about where he lays his head at night, and it isnt the multi-million-dollar mansion that most would expect the worlds richest man to live in.

Instead, he makes do with a small three-bedroom property located right near his SpaceX rocket factory.

The Tesla CEO has certainly had his hands full this year as the billionaire has found himself caught in the middle of a lawsuit following the collapse of his Twitter buyout.

Wasting no time, he has now jokingly suggested buying another unexpected venture: Manchester United.

It comes as the team is battling setback after setback.

Image:

If we won the lottery tomorrow, many people would immediately go out and buy their dream home: a mansion, beachside pad, or city-centre penthouse.

Even though he is the worlds richest man, Elon spends most of his time in a house that cheaper than most luxury treehouses.

During an interview on the Full Send podcast, the Boring Company CEO said he bought a $45,000 (37,160) house, mainly due to its location in Boca Chica, Texas, which is within walking distance of his SpaceX factory.

The house that I bought actually costs less than whats in a Boxabl, Elon told the podcast. It cost like $45k or something, but Ive done a lot with the place.

Boxabls are tiny homes and a building system that can be built to almost any style of house, costing between $5,000 (4,100) and $50,000 (41,200).

Image:

The podcast host asked if the home is small, and Elon replied: Its small. Its very small. Its a tiny its a small, small house.

He added: "Its right next to the rocket factory, so I can just literally walk to the rocket factory, its like half a mile away.

Explaining the layout of the home, he continued: Its technically a three-bedroom, but it used to be a two-bedroom.

I converted the garage into a third bedroom.

Yeah, its like, friends of mine come and stay there and they cant believe Im staying in this house.

Asked if he likes living like that, he said: Yeah, if Im there by myself its fine.

It's worth noting that this is just one of his homes, as the billionaire has a small property empire.

He owns four mansions in Bel-Air, a pad in Brentwood, California, and another nearly 100-year-old mansion in San Jose.

Image:

Elon has once again got himself in hot water thanks to an irreverent tweet that was posted earlier this week.

The Neuralink CEO shared a tweet explaining his political preferences, stating: To be clear, I support the left half of the Republican Party and the right half of the Democratic Party!

He replied, with a seemingly unrelated remark, he wrote: Also, Im buying Manchester United ur welcome.

The tweet received over 500,000 likes in less than 24 hours, with many social media users confused over the randomness of the post.

The account Tesla Owners Silicon Valley replied: Are you serious?

The billionaire replied: No, this is a long-running joke on Twitter. Im not buying any sports teams.

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Elon Musk actually lives in tiny 37k house as he jokes about buying Man United - The Mirror

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Drake Celebrates Breaking The Beatles Record With Roulette – UPROXX

Posted: at 1:07 am

Yesterday, Drake topped another significant record by The Beatles. When the track Staying Alive by DJ Khaled with Drake and Lil Baby checked into the Billboard Hot 100 at the number five spot, it marked Drakes 30th Top 5 single on the chart, thus breaking the tie at the top he previously held with The Beatles at 29. So what did Drake do to celebrate the accomplishment? He went on a high-stakes gambling roulette run, of course!

Drake is a noted gambler who won big money betting on the Golden State Warriors this past NBA playoffs, scored over $1 million in Super Bowl bets, and then won and lost over $25 million playing video roulette with French Montana. His roulette bets have all been on the online cryptocurrency betting platform Stake, whom he partnered with this past March. So immediately following the news of his record-breaking hit, Drake posted a headline and the a video on Instagram of himself winning $5,130,000 million on a roulette play. His betting was livestreamed on Twitch, which is something he often does when hes betting big money, presumably to raise the profile of the Stake platform. Ok I broke my records for the month now me and Stake need you to do your thing Bitcoin, he commented on an Instagram.

Since the $5,130,000 is paid out in Bitcoin, Drake would stand to make even more if the price of the cryptocurrency shoots up. Hence him asking for Bitcoin to do your thing. He better hope that French Montana isnt around though

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Drake Celebrates Breaking The Beatles Record With Roulette - UPROXX

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What Are The Most Popular Games Played on Casino Apps? – Qrius

Posted: at 1:07 am

Looking for some casino games to play on your phone? Youre in luck. There are tons of great casino games that you can enjoy on your mobile device, from slots and scratch cards to classic table games like blackjack, roulette, and baccarat. This article will examine some of the most popular casino games on mobile apps.

Among the most popular dice games and casino games in the world, craps is without a doubt one of the most popular. If you want to play something fast-paced and action-packed, Craps is an excellent choice. The object of the game is to roll two dice and place a bet on the outcome.So craps is a game that you can use to Play casino online for real money and win.

Bingo is yet another traditional game that has been updated for the mobile app industry. There are numerous bingo games to select from, and there is generally a room full of people eager to take on the challenge. Its a simple game: fill out your card with the numbers shouted out by the caller. Bingo is an excellent alternative for those looking for a basic game to learn.

The Wheel of Fortune is a well-known and straightforward casino game. All you have to do is spin the wheel and hope it lands on the desired prize. You could win a hefty prize if youre lucky.

Scratch cards are a popular choice for casino players looking for a quick and easy game. You only need to scratch off the panels to reveal the symbols underneath. If you match three symbols, you win! Its as simple as that.

Arcades are a great option for casino players who want to take a break from traditional games and try something new. There are many different arcade games, ranging from classic favorites like Pac-Man to more modern options like Candy Crush. Your favorite arcade game is sure to be available no matter what your taste is.

One of the most traditional and popular casino games is roulette. The objective of the game is to correctly anticipate where a ball will land on a spinning wheel. Its possible to walk away with a substantial sum of money if youre lucky.

Poker is another classic casino game adapted for the mobile app market. There are many different poker games to choose from, and you can usually find a room full of players ready to take on the challenge. The games object is simple: be the best poker player in the room. Poker is worth checking out if youre looking for a fast-paced game with plenty of action.

Baccarat is a very common card game in casinos all around the world. The goal of this game is to guess which hand will come closest to nine. If youre lucky, you go home with a large quantity of money.

Blackjack is a famous casino game that is also one of the simplest to learn. The goal of the game is to go as close to 21 as possible without going over. Then, if youre lucky, you might walk away with a large payout. Its a game with amazing Jackpots Secret Gamings Weapon, so why should you not try it?

Live dealer games are an ideal choice for casino players who want to experience the thrill of playing in a real casino environment. These games are aired live from a casino studio, and you can engage in real time with the dealer and other players. Live dealer games are worth trying if you want a full casino experience.

Keno is a lottery-style game that is popular in casinos around the world. The games object is to choose a set of numbers and hope they are drawn. If youre lucky, you could walk away with a big win. To play Keno, you must choose a set of numbers and place a bet. Then, sit back and hope that your numbers are drawn!

Sic Bo is a popular dice game found in casinos all over the world. The goal of the game is to gamble on the outcome of a three-dice roll. With a little luck, you might walk away with a lot of money.

Slot machines are one of the most popular and simple casino games. You are only expected to spin the reels and hope for a winning combination.If youre lucky, you could win a large prize.

Video poker is a popular choice for casino players who want to experience the thrill of playing poker without the pressure of competing against other players. The games object is to create the best hand possible, and hope you win. If its your lucky day, you could get a big win. With video poker, you can enjoy the game at your own pace and try to beat your own personal best.

There are tons of casino games available on mobile apps, and theres sure to be something that everyone will enjoy. There will undoubtedly be a game that you will appreciate, whether it is a traditional game like roulette or something more modern like arcades. So what are you waiting for? Start playing today.

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What Are The Most Popular Games Played on Casino Apps? - Qrius

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