Monthly Archives: July 2022

AI Startup Speeds Healthcare Innovations To Save Lives – Forbes

Posted: July 14, 2022 at 10:28 pm

Michelle Wu, cofounder and CEO and KK (Qiang Kou ) tech cofounder at Nyquist Data, an AI powered ... [+] cloud-based platform providing business, clinical, and regulatory intelligence and analytics for medical devices and pharmaceuticals companies

How long does it take to get FDA approval for a heart-failure drug?

It sounds like a simple question, but without the help of an artificial intelligence (AI) powered MedTech cloud-based platform, it could take months and millions of dollars to find out. The market size for AI in healthcare is projected to reach $187.95 billion by 2030, according to Precedence Research.

When Michelle Wu was first asked this question, global clinical and regulatory healthcare information was publicly available, but it was scattered around the world in different databases and languages. Worse yet, keywords were misspelled or there were handwritten notes included in the databases, making what should be searchable unsearchable.

Using AI, big data, and machine learning, Wu launched Nyquist to provide business, clinical, and regulatory intelligence and analytics on medical devices and pharmaceuticals across major markets, such as the U.S., Japan, the E.U., and Chinawithin seconds.

When Wu was the global strategy manager at Novartis, the CEO asked her about the length of time it takes the FDA to approve a new heart medication. "It's the #1 cause of death in the U.S.," she said. Heart disease costs the U.S. about $363 billion annually, according to the CDC.

Over the next three months, Wu read tons of FDA approvals that were 5,000 pages long in which maybe there were one or two relevant paragraphs. She also spoke with many experts. Then Wu compiled the data into Excel spreadsheets so that she could answer that simple question.

"This is insane," exclaimed Wu. Vital healthcare information that could be mined to provide insights into how to develop life-saving medical innovations faster and at a lower cost was available but in arcane, black-box computer systems. "There has to be a better way," Wu thought.

This project was a light-bulb moment for her. The financial industry had Bloomberg to analyze content and data to help investors uncover opportunities and minimize risk, and pharmaceutical, biotech, and medical device companies needed something similar.

Wu left Novartis to attend Stanford Graduate School of Business (GSB) to work on the idea. She also worked at a couple of startups before starting Nyquist.

In 2020, Wu and her cofounder KK (Qiang Kou), raised $523,000 in pre-seed funding from former Google, Amazon, big pharma, and MedTech executives and launched Nyquist. The startup aggregated medical data worldwide and then connected the dots, making the information valuable to analysts, R&D departments, and commercial teams in pharmaceutical and medical device companies.

By using Nyquist platform, pharma and medical device companies can speed up the process of medical innovations in the U.S., Japan, and the E.U. reaching China, India, Africa, and other emerging markets and vice versa. Companies in emerging markets are developing many cheaper and effective healthcare innovations. The world needs to know about these. The process of getting approval from one country to another can take 2 to 7 years.

Over the course of two years, Nyquist has developed the largest AI data platform for medical devices. "We have about 30 customers from seven countries," said Wu.

Working collaboratively with prospects and customers like Medtronic, Nyquist has discovered new uses for its platform. During a pitch call with Medtronic, an executive asked if the platform could be used to research supply-chain factories. Within a few moments, Medtronic had a list. There was silence and Wu thought the video had frozen. Then she heard mumbling and paper rustling from the Medtronic side of the call. Shortly after the call, Nyquist had a new customer.

When raising Nyquist's seed round, Wu experienced the typical naysayers. Old white men who told her no one would pay more than $50 for publicly available information.

Then she was introduced to Ilana Stern of Peterson Ventures, who quickly saw how arcane, manual, messy, costly, and lengthy the current process was. "They're helping medical device companies, and eventually pharma companies accelerate and increase the success of clinical trials and bringing products to market," said Stern. "What's most important is the lives impacted in getting innovation to market more quickly."

"It's the way they're harnessing natural-language processing, AI, and machine learning to ingest and organize data to surface insights is incredibly powerful," said Stern. "With the click of a button, you can look at the equivalent of FDA data in Japan, China [and many more countries]."

Stern was also impressed that Wu raised half a million dollars in pre-seed funding, considered a small amount of money. Yet, she built out a platform used by customers, including Medtronic, and Becton, Dickinson and Company, also known as BD.

The startup raised $6 million in March of 2022. Peterson Ventures led the round with participation from GSR Ventures, Lightspeed Ventures Partners, and Village Global. "We will soon launch our pharma platform," said Wu. Nyquist will also expand its global MedTech platform to include 108 clinical sites worldwide.

Another challenge is constantly aggregating all the global insight and data. One way they have overcome this challenge is that the team is geographically diverse, coming from Asia, Switzerland, Germany, and the U.S. But it is also diverse in gender and sexual orientation. "More than 50% of our employees are women and we have a lot of queer moms." Diversity improves performance and outcomes.

In addition, "We just graduated from Google Accelerator," said Wu. "It's like learning to paint from Leonardo da Vinci. They bring the creme de la creme of AI experts [for participants to learn from]."

Still, this young company is doing more. "There are a lot of clinical trials and medical device companies that have suffered during the Russian-Ukrainian war," said Wu. "We are helping a couple of medical device companies in Eastern Europe pro-bono move their clinical trials and manufacturers outside the war zone."

How can your business fill a market gap?

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ECOO seeking optometrists to take part in AI screening project – AOP website

Posted: at 10:28 pm

The European Council of Optometry and Optics (ECOO) is calling for optometrists to express an interest in an EU project investigating artificial intelligence (AI) and retinal imaging.

The I(eye)-Screen project seeks to partner AI experts with ophthalmologists and optometrists who use optical coherence tomography (OCT) to screen for age-related macular degeneration (AMD).

The project identified AMD as the most common cause of legal blindness in people over the age of 50, with 110 million individuals at risk. Signs of the disease can be identified by OCT before visual symptoms occur.

The initiative, which involves all EU countries as well as Great Britain, Norway and Switzerland, will see participating optometrists performing OCT imaging with adults above 55 years old with functional vision. Images will be analysed for early or intermediate age-related macular degeneration by an AI group.

If AMD is identified, the patient will be referred to a partnering ophthalmologist who will perform a clinical follow up four times a year over the course of three years, to identify progression.

If the project is approved, it is expected that a budget will be granted to cover the screening and referral of images.

The optometrist will screen approximately 200 to 250 individuals over one year, and refer around 25 individuals to the partnering ophthalmologist.

Following the study, researchers seek to make a reliable AI-based tool available for the optical community, along with a legal framework as a base for collaboration.

ECOO has outlined that all optometrists using a Topcon Maestro OCT are encouraged to apply. Applications can be made through an online form.

Julie-Anne Little, AOP chairman, said of the initiative: Involvement in studies such as these are important opportunities to ensure that optometry has a voice in how AI tools and machine learning may be employed in eye care in the future.

Little added: Primary care optometrists need to be central to how such tools can deliver effective integrated eye care for patients.

Optometrists who are already in contact with an ophthalmologist using a Spectralis OCT, and would like to work with them, can indicate this on the application form. Optometrists without a contact will be matched through the initiative.

The deadline for expressions of interest is 30 July, with earlier applications standing a higher chance of success.

Inviting optometrists to express an interest in the study, ECOO agreed that the project is a key opportunity for the profession to have a voice in the use of AI tools, to input in any guidance on the topic and to define how shared care is taken forward.

ECOO, which represents national associations from 21 countries across Europe, is part of a consortium of stakeholders collaborating on the EU funding application for the project.

An EU research grant for Personalised screening and risk assessment next door for life-long healthy vision based on automated AI-tools has already been successfully submitted, receiving the highest score and moving to the final round of the funding application.

The proposal has been based on the fact that 200 million individuals worldwide are affected by AMD, and 1.9 billion people are at risk, ECOO said.

The project will first gather retrospective data sets to train an advanced AI-based algorithm for early and intermediate AMD identification and detection of risk progression.

A prospective clinical study would then take place, collaborating with optometrists to validate the performance of the AI algorithm using OCT devices. This would be followed by a proof-of-concept of feasibility, where independent optometrist sites across Europe will screen individuals in a real-world setting to collect data for validation.

The final stage of the project would be an EU-conforming ethical and legal framework providing health care measures, preparing regulatory approval, and establishing AI-based prevention strategies.

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Retouch4Me Review: AI Retouching That Actually Works – PetaPixel

Posted: at 10:28 pm

Some may enjoy editing, but most photographers will agree that actually taking the photos is the best part of the job. So finding a way to speed up and reduce the amount of time spent at the computer is more than welcome, which is where Retouch4Me comes into play.

The Retouch4Me plugins are designed specifically to address the most common workflow issues portrait photographers face in their day-to-day work, with each plugin separately developed to address a specific retouching situation. The company has plugins that specifically target background cleanup, healing skin blemishes, cleaning up wrinkles and tears in fabrics, cleaning up and enhancing eyes, whitening teeth, making skin tones uniform, adding volume and contrast, as well as an overall dodge and burning of the visible skin in the image.

While each tool is a separate task, they actually speed up the retouching process by a noticeable amount, making it easy to breeze through dozens of images with only minor required manual corrections, effectively freeing up hours of post-production time.

For this review, I tested all of the available plugins, including the whitening teeth tool and the heavy-handed eye brilliance tool on an Intel based MacBook Pro and M1-equipped Mac mini.

As full-time photographers, we dont make money while were sitting behind the computer doing the edits. So we take classes, buy tutorials, and then buy plugins and actions to speed up that post-processing work so we can get out and book the next client.

Naturally then, I was both excited to see if the Retouch4Me plugins worked and skeptical given how tools to this point have not come close to the performance expectations of a professional retoucher. Luckily enough, I was actually very pleasantly surprised with just how powerful these plugins actually are.

Unlike most software suites where everything is baked into one application as a big all-encompassing platform, Retouch4Me is offered as individual plugins that, while not cheap, allow potential users to pick and choose exactly what steps in their workflow they would like to have sped up and automated.

Retouch4Me currently have nine individual plugins for a variety of tasks that can be used as a stand-alone app or launched through Adobe Photoshop, Lightroom Classic, or Capture One Pro. In their current state, each plugin has to be run individually on a particular image (meaning there isnt a bulk-edit option), however, you can make your own Action in Photoshop that can automate the process of running multiple plugins one after the other. This can lead to some hiccups and crashes (from my experience) depending on the images and what is in them, so while you can do this, Id personally recommend just running things manually.

Overall, the plugins are designed to take the stress and pressure out of portrait retouching, while saving you time behind the computer. While the plugins can get expensive (they range from $124 to $149 per plugin), once you start adding them together, their value in the time saved will be beyond measure.

For the purpose of my review, I tested the plugins through Adobe Photoshop as a filter/plugin applying masks and opacity changes as they were needed. The first thing worth noting is that the Retouch4Me plugins work on whatever the current layer you have selected in Photoshop, so if you start using multiple plugins or prefer to keep things organized in your layers, you will have to pay close attention to click the tools as they do not label themselves or create new layers.

I recommend creating a new layer for each plugin you plan to run, that way you can mask and apply as lightly or heavily as you like after the fact. In the gif below, I took a RAW file from a recent fashion shoot and did a fully automated retouch (with some minor manual tweaks in between) on new layers for each tool labeling each along the way.

I choose the following workflow order: Backdrop Clean up, Skin Tone, Portrait Volume, Dodge and Burn, Fabric, Eye Vessels, Eye Brilliance, and then Healing.

For this particular image, everything worked almost perfectly with no adjustments needed except for dialing back the Eye Brilliance (it was super heavy-handed and I ended up turning it down by about 70%). While Eye Brilliance does work, there is never a good reason to go that crazy on it unless youre making a superhero or monster movie poster.

The plugins work impressively well and the entire process took less than five minutes from loading into Photoshop and saving as a final jpeg. In most situations, especially in fashion work, there will be some things that need cleaning up like stray hairs and fixing bulges or folds in the clothing, but thats the easy part most of the time. The skin work and fabric and backdrop cleanup in this particular shot were executed pretty flawlessly.

While each application is run individually, the layout and tools available within them are rather similar to one another. For instance, below is how the plugin windows look while running the Fabric Clean up tool on the above image:

When you load the layer into the plugin, the program analyzes the image and then chooses what it feels the best course of action is to fix the image. You can choose between a full-length, three-quarter, close-up/headshot, or Auto modes to operate with. For the most part, the auto mode works brilliantly, at least in clean studio images, but for busier shots with lots happening in the background or foreground, you may want to play with these options to ensure you get the best results.

The plugins allow you to see the before and after of the edits and even provide you with some tools to paint in additional areas or even erase them where the app may have gone a bit heavy. While those tools do work, at least in my experience they didnt work very well and were quite laggy. It was actually a lot easier to just let the application do what it needs to, then mask/paint things away in photoshop directly afterward.

Here are the masks and edits applied from the rest of the toolset:

As you can see from the images above, sometimes the masking and AI tools can go a little heavy-handed, or even miss things like some threads on the floor. For example, the Eye Brilliance tool and the Dodge and Burn screenshots show some unnecessary masking and applications.

And like most plugins, Retouch4Me can go pretty heavy-handed on the tools, meaning in practical applications you may want to scale back the opacity on some of the effects. For the image above, I left everything (except the eye brilliance) at 100% just so it could be easy to see how it all works, but in actual use cases, most every tool was scaled back anywhere from 90% down to 30% opacity depending on the project.

One plugin, in particular, gave me quite a few headaches, and that was the healing tool. While it works really well, it often goes very overkill with its healing by removing jewelry, piercings, and even tattoos or tufts of hair, as the application interprets it as a blemish. Other than it going a bit hard on my subjects, it still did a great job fixing the skin, and 90% of the time Id let it go at 100% and then just mask the areas away where it shouldnt have fixed.

Additionally, it is worth noting that there were some crashes in the application that would cause not just the plugin, but Photoshop as a whole to crash. This would cause me to lose anything that wasnt saved before running the particular plugin , so you are going to want to save often.

When communicating with the support team, they said the crashes were caused by me having too many things running on my computer, (Capture One, Lightroom, Photoshop, Chrome, etc.) which could cause my computer to run out of memory during a process, causing the crash.

To me, that sounds like the plugins can gobble up a lot of memory and/or there is a memory leak issue. I did some heavy testing of this and did find that after running the plugins on dozens of images, everything did slow down and the plugins did indeed chew through memory. A simple reboot seemed to fix those issues when they would happen.

For the most part, the heal, dodge and burn, portrait volume, skin tone, eye brilliance, vessels, and teeth whitening tools all worked perfectly and as intended 100% of the time. The plugins that I found were more likely to cause a crash were the backdrop cleanup and fabric tools. With images that were incredibly busy and colorful or had extremely shallow depth of field shot outside of the studio, running the fabric and background tools could cause a total crash. The support team is working on this, but at the time of publication, I still havent gotten an answer.

What I believe is happening is the application is scanning the image and looking for imperfections in the background or clothing, but gets overwhelmed with everything it finds and just crashes. The behavior I would have expected is the app simply doesnt do anything in that case or maybe throws an error back saying it couldnt work, but instead it just crashes. It doesnt happen all of the time, but it is consistent enough to warrant a warning for potential users to be sure to save their files frequently and especially before running those particular plugins, just in case.

Despite the occasional application crash or heavy-handed application of a tool, the Retouch4Me plugins can transform your images incredibly fast with minimal effort. If nothing else, they can help you get into a great starting point to do some manual tweaks and retouching by hand, which still saves you hours of work behind the computer.

The fact that the set of plugins is broken into separate components can feel clunky, but I understand the decision since it allows users to pick and choose the elements that give them the most headaches and target that area to eliminate.

The best part about these tools is that unlike other AI-based applications, the Retouch4Me plugins do not require an active internet connection to work. All of the edits happen locally and your clients photos remain secure on your computer.

The bottom line here is yes, these plugins are actually good! Even with some of the quirkiness, the results speak for themselves and I definitely plan on incorporating these plugins into my commercial client work moving forward.

It should be noted that none of these are actual full-on replacement alternatives for what Retouch4Me has here, but AI has become heavily integrated into editing software in recent years, so there are a lot of applications out ther for photographers to choose from based on their personal preferences.

One of the most popular and commonly known is the $89 Luminar AI / Luminar NEO tools from Skylum that offers a broad suite of AI and manual editing tools under one roof. ImagenAI is another all-in-one solution that even offers batch processing from $0.06 per image, but this application is really meant for high-volume photographers who deal with thousands and thousands of images, and works specifically with Lightroom catelogues.

Additionally Topaz Labs has a series of AI based tools ranging from $59 to $99 per application, or available for $199 as a bundle. Finally, even Adobe Photoshop is getting into the AI game with its Neural Filter beta program which includes things like Sky Replacements, Skin Smoothing, and JPEG artifact removal. While these arent exactly time savers like some of the others, they can provide some good starting points and creative features for retouchers looking for a head start on their work.

Yes. Honestly, every one of the tools that Retouch4Me has built (except for the Eye Brilliance) is worth the investment. If you spend a large amount of time behind a computer retouching your portrait work, any one of these individual tools can potentially save you hundreds of hours of retouching time every year.

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Innovative Dental AI Solution from VideaHealth to Power Exceptional Patient Experience at 42 North Dental Supported Practices – Business Wire

Posted: at 10:28 pm

BOSTON--(BUSINESS WIRE)--VideaHealth, the leading dental diagnostic AI solution, and 42 North Dental today announced a partnership to scale patient-centered AI technology in the dental industry. By deploying VideaHealth AI in several of its supported practices, which include Gentle Dental and over 38 additional brands, 42 North Dental is equipping dentists with the power of AI for chair-side decision making. The VideaHealth AI solution, coupled with 42 North Dentals relentless focus on delivering the highest quality patient experience possible, will set the industry standard for how todays dentists engage with patients.

Michael Scialabba, DDS, Chief Clinical Officer at 42 North Dental, said, When I evaluate partners for 42 North Dental, Im looking for cutting edge leaders that provide a new benefit to patients. We knew partnering with VideaHealths dental AI solution would bring the power of AI to dentistry and give our dentists a powerful tool to provide more accurate diagnoses than ever possible before. In turn, this helps our dentists provide the highest-quality dental care to patients through a combination of traditional dentistry and advanced digital aids like VideaHealth dental AI.

The VideaHealth dental diagnostic AI solution eliminates patient concerns such as transparency of diagnosis or the potential overuse of X-rays by giving dentists the benefit of the industrys most accurate AI in an easy-to-deploy way. Launching the VideaHealth dental diagnostic AI solution with visionary leaders like 42 North Dental will help pave the way for massive AI adoption in the industry.

42 North Dental is a leader in delivering top-tier comprehensive care and an exceptional patient experience. Were honored to be working together to improve the lives of patients, said Florian Hillen, CEO and founder of VideaHealth. Our partnership will move the entire industry forward as we work with select 42 North Dental supported practices to provide fair, accurate and equitable treatment for everyone who needs it.

With technology and software solutions that assist dentists in analyzing patient X-rays, VideaHealths AI technology helps ensure every patient gets an accurate diagnosis and every provider captures efficiencies and faster reimbursement to scale and grow. Its solutions are designed to integrate seamlessly with existing practice software and tools without adding steps or complexity to the dentists workflow. VideaHealths FDA-cleared AI algorithms are based on the VideaFactory, which houses the industrys most diverse dataset with more than 100 million data points.

About 42 North Dental LLC

42 North Dental is a leading dental organization supporting 42 practice brands in 113 locations. Committed to eliminating barriers to quality patient care by providing administrative support to dental practices, 42 North Dental presents opportunities that help doctors and their teams professionally advance while growing the practice to its fullest potential. 42 North Dental's affiliation model offers dental providers clinical autonomy and equity ownership, as well as unmatched administrative support. 42 North Dental was created for dentists and is rooted in over 40 years of experience in dentistry.

About VideaHealth

Founded in 2018 and born out of Harvard and MIT artificial intelligence (AI) research, VideaHealth is on a mission to improve dental patient health through the power of AI. VideaHealths FDA 501(k) cleared platform drives the improved quality of care for patients by using AI to augment the diagnosis and treatment planning capabilities of providers. Partnering with leading DSOs across the country, VideaHealth is committed to helping usher in the age of preventative care in dentistry. Backed by leading venture capital firms Spark Capital, Zetta Venture Partners and Pillar VC, and angel investors, VideaHealth is headquartered in Boston. For more information, visit https://www.videa.ai.

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Governor Lamont Announces Opening of Evolution Gaming Studio in Connecticut – CT.gov

Posted: July 13, 2022 at 9:27 am

Press Releases

07/11/2022

(HARTFORD, CT) Governor Ned Lamont today announced that Evolution, a live casino operator for digital platforms, has begun operating in Connecticut. The company, which has already hired 140 employees to work at its newly built studio in Fairfield, is expected to hire up to 400 total workers in Connecticut, offering technical, production, administrative and information technology positions, as well as security.

With the addition of Evolution, we are continuing to provide a modern, technologically advanced gaming experience that provides an elevated user experience for eligible residents and is competitive with our neighboring states, Governor Lamont said. Connecticut has proven to be a leader when it comes to the gaming economy going back decades, and this expansion allows those who want to participate to continue doing so, responsibly.

We are proud of the hard work our Gaming Division has done to ensure Evolutions facilities and offerings meet the high standards set by our regulations to create a safe and successful opportunity for live dealer games in Connecticuts online gaming marketplace, Connecticut Department of Consumer Protection Commissioner Michelle H. Seagull said. We encourage anyone who chooses to participate in this new form of online gaming to do so responsibly by monitoring their activity and setting limits for themselves utilizing the tools that are required to be available on these platforms.

Evolution began operations with a seven-day soft launch, authorized by the Connecticut Department of Consumer Protection, at 11:00 a.m. on Monday, July 11, 2022. Evolution will provide live dealer games on both the FanDuel and DraftKings iCasino platforms offered in Connecticut. During the soft launch, only blackjack and roulette tables will be available to a limited number of participants. The soft launch will transition seamlessly into the full launch at 11:00 a.m. on Monday, July 18, 2022, pending the resolution of any issues discovered in the soft launch.

The Connecticut Department of Consumer Protection will monitor the soft launch to ensure Evolutions games meet the states regulations for online gaming. Connecticut law requires Evolution to operate an in-state facility in order to offer live dealer games on Connecticut gaming platforms.

Information about gaming in Connecticut, including the most up-to-date statistics, is available at ct.gov/gaming.

Information on services available in Connecticut for those who may have a problem with gambling is available at portal.ct.gov/problemgaming. Information about self-exclusion is available at ct.gov/selfexclusion.

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NetBet Italy partners with Evolution – GlobeNewswire

Posted: at 9:27 am

ROME, July 12, 2022 (GLOBE NEWSWIRE) -- NetBet - one of Italys most popular online casinos - has introduced the best titles from Evolution to its players.

NetBet Italy is progressively forging their identity as an exceptional online casino for the Italian market, continuously evolving their product offering to bring players the best games in the industry. Evolution are a well-respected developer whose products already have a strong following across NetBets international markets.

Evolution are experts in creating Live Dealer and RNG games that appeal to all kinds of players. This partnership with NetBet Italy will make highlights from their catalogue, including Live Roulette, Live Blackjack and Lightning Roulette, available to fans of Live Dealer games.

NetBet Italys PR manager, Claudia Georgevici, said: Evolution are a fantastic brand that were delighted to bring into the fold. Were certain that our players will enjoy their unique brand as part of their NetBet playing experience.

For more information contact pr@NetBet.it

About NetBet.itNetBet.it is a single-member BPG srl site, founded in 2008. It is one of the first Italian portals specialising in online gaming and is licensed by ADM. With access to thousands of industry-leading casino games and daily sports events, NetBet.it has evolved into one of Italy's favourite online gaming brands.

For more information please visit: https://www.netbet.it

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Researchers Study the Molecular Basis of Carnivorous Plants and Found the Evolution of Them Through the Past – Nature World News

Posted: at 9:27 am

For more than a century, insect-eating plants have captivated biologists, but how plants gained the capacity to catch and eat live prey has mostly remained a mystery.

Scientists from Salk and Washington University in St. Louis have now studied the molecular underpinnings of plant carnivory and discovered evidence that it developed from defense mechanisms used by plants.

(Photo : Andi Superkern/Unsplash)

The study described how calcium molecules move dynamically within cells in the leaves of carnivorous plants in reaction to touch from living prey.

It was published on July 11 in Proceedings of the National Academy of Sciences (PNAS).

Changing calcium levels cause leaves to move in order to grab prey, perhaps by producing more defense-related hormones, as per ScienceDaily

The information advances scientists' knowledge of how plants interact with their surroundings.

In order to live in nutrient-poor environments, plants like the spoon-leaved sundew (Drosera spatulata) probably evolved carnivory.

However, because sundews are difficult to produce and their DNA has only recently been decoded, researchers have had trouble understanding how carnivory functions at the cellular level.

Additionally, they were unaware of how carnivorous plants evolved prey-capture-related characteristics including leaf motion and the release of digesting enzymes.

Carl Procko, the co-first author of the research and a staff scientist in Salk's Plant Molecular and Cellular Biology Laboratory, asserted that carnivorous sundew plants are not model organisms.

The scientists had to learn new procedures to closely investigate the plants because only a small number of labs throughout the world had previously been able to genetically change them.

To conduct this work, the researchers used genetic methods to visualize the dynamic changes in calcium molecules in the leaves as insect prey touched down on them and were subsequently trapped by sticky secretions.

Calcium signaling is essential for non-carnivorous plants in several ways, including activating the jasmonate defense pathway to ward off pest insects.

Electrical activity, a crucial component of prey capture in some carnivorous plants, including sundews, is similarly reacted to by jasmonic acid.

The researchers wondered if the carnivorous habit of the sundew would also require this similar defense mechanism found in non-carnivorous plants.

The team discovered that as the leaf bent inward, encasing the insect in digestive secretions, changes in calcium within the plant cell were necessary for the activation of genes generally targeted by jasmonic acid.

Sundew leaves exhibited less bending when offered non-living prey and when their calcium channels were blocked, according to the researchers.

These results support the hypothesis that jasmonic acid is involved in insect digestion and show how calcium facilitates insect prey-capture reflexes.

Also Read: Carnivorous Plant Gives Unique Insight on 'Junk' DNA

The evolution of generally mild-mannered floral plants into homicidal meat-eaters is one of botany's greatest unanswered mysteries, and carnivorous plants are currently experiencing another major turning point, as per theSmithsonian Magazine

More recently, developments in molecular science have aided researchers in understanding crucial mechanisms underlying the carnivorous lifestyle, such as how a flytrap snaps so quickly and transforms into an "intestine" to absorb its prey's leftovers after crushing insects.

But the fundamental question remained: how did evolution give these meat-eating dietary outlaws the ability to do so?

Despite being strange, carnivory has undergone numerous evolutionary changes during the more than 140 million years that flowering plants have existed.

According to Tanya Renner, an evolutionary biologist at Penn State, the adaption appeared independently at least 12 times.

The necessity to discover a different supply of essential nutrients catalyzed evolution each time.

Carnivorous plants thrive in ecosystems deficient in the nitrogen and phosphorus necessary for growth, such as swamps and bogs, nutrient-poor bodies of water, and thin tropical soils.

Both, as well as other nutrients plants, require to thrive, are abundant in insects and other tiny invertebrates that are high in protein.

Many aspects of the carnivorous way of life are still guarding their genetic secrets.

However, research on two of its most gruesome components-digestion and absorption-is showing how evolution repurposed already-existing genes, giving some new jobs to do while giving others new functions and the occasional change to better fit their new responsibilities.

The same genes have frequently been reused in plants that separately developed carnivory.

Beyond digestion, evolution has a propensity to acquire and modify existing tools.

The trap must transfer the smaller molecules created as chitin, proteins, and DNA are broken down from the outside environment to the interior of the plant.

Related Article: Taste for Meat: Scientists Trace Genetic Route of Carnivorous Plants

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Inside the Evolution of Grime Music | Smart News – Smithsonian Magazine

Posted: at 9:27 am

Grime artist Jammers basement studio Courtesy of the Museum of London

Originally an underground sound, grime has gone mainstream in Britainand since its creation, it has become hugely influential for artists around the world.

Now, a new free exhibition celebrates the scenes origins and evolution. Grime Stories: From the Corner to the Mainstream at the Museum of London features photos, videos and memorabilia documenting two decades of grime.

The display is co-curated byRoony RiskyRoadz Keefe, who the museum calls one of grimes early documentarians. In particular, his DVD series Risky Roadz helped propel artists to fame in the years after the genres creation. Per theGuardians Joseph Patterson, much of what is on display comes from the archives of Keefe and others like him.

Grime is one of those genres that once its in you, it never leaves, Keefe tells the Guardian.

The museum originally asked Keefe, a London cab driver by day, to conduct interviews about the grime scene in the back of his taxi. Now, a series of films, which include Keefes interviews with influential grime artists like Skepta andDJ Slimzee, are at the center of the exhibition,BBC News reports.

Its a big thing, you know, says Keefe to the New York Times Desiree Ibekwe. You never think youre going to end up in a museum.

Grime emerged in the early 2000s among artists in east London who wanted a sound that was uniquely theirs. It was both an evolution from and reaction to U.K. garage music, as the Times writes. Other British forms of rap had become overly Americanized, some felt, with slang borrowed from across the Atlantic.

While the genres definition has evolved over the years, grime music generally has a tempo of 140 beats per minute; the Guardian describes it as post-punk angst on waxa heady mix of dancehall, jungle and U.K. garage, inspired by Jamaican ragga toasting and the storytelling of U.S. hip-hop.

Artists in the scene align themselves with grime crews that produce and perform music together. One of the most notable crews isRoll Deep, formed in the early 2000s, which has included performers likeWiley,Danny Weed,Breeze, Skepta andDizzee Rascal.

In recent years, grime has seen a resurgence with the arrival of new artists likeStormzy, who the Times calls grimes most successful breakout. In 2017, the Labour Partys Jeremy Corbyn enlisted grime artists toencourage the public to vote for him, per the Times. In 2019, IKEA featured grime M.C. D Double E in a Christmas commercial.

This is a monumental moment in the U.K., especially for Black British culture, Jammer, an early grime artist, tells the Guardian.

From the early days, Jammers familys basementknown as the Dungeonwas a critical place for grime artists, and the new exhibition features many references to the space.

When grime began, he adds, it was the only thing we knew how to do to make a better life for ourselves. Grime is like our therapy: you go into it with your pain, get your lyrics out and then you get better and you learn.

Grime Stories: From the Corner to the Mainstream is on view at the Museum of London through December.

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Case study of the convergent evolution in the color patterns in the freshwater bivalves | Scientific Reports – Nature.com

Posted: at 9:27 am

Remarks on the residual color patterns in the Kitadani Freshwater Bivalves

Residual color patterns in the form of visible pigmentation on fossil molluscan shells are generally uncommon2,3. In the Paleozoic to Mesozoic fossil records, the color patterns were limited to marine species3, which are preserved as black to dark-colored bands running on the shell surface as melanin pigments20,21. The black to dark-colored stripes on the shells of the Kitadani Freshwater Bivalves resemble the color patterns in some extant freshwater bivalves, suggesting that the dark bands are residual color patterns remaining as melanin pigments. Consequently, the Kitadani Freshwater Bivalves represents the oldest and second fossil record of residual color patterns among fossil freshwater bivalves.

The residual color patterns of the Kitadani Freshwater Bivalves resemble the color patterns of extant freshwater bivalves in terms of width, number, and distribution of the colored bands. Both the Kitadani Freshwater Bivalves and extant freshwater bivalves examined in this study consist of two types of color patterns: stripes along the growth lines and radial rays tapered toward the umbo. Notably, the former pattern is similar among all the species examined, as it forms in the peripheries of prominent growth lines occurring periodically. In the latter pattern, however, the morphology and distribution of the bands are slightly different between the Kitadani Freshwater Bivalves and the extant species. The Kitadani Freshwater Bivalves exhibits relatively distinct and wide radial rays running roughly parallel to the lengths of the sculpture elements (radial plications and/or wrinkles), while the extant species bear obscure and fine radial rays running diagonally to the lengths of the sculpture elements. Nonetheless, the taxa with V-shaped sculpture elements (wrinkles, ribs or arranged nodules) lack or bear ambiguous radial rays, whether extant (e.g., Triplodon spp., Indochinella spp. and Tritogonia spp.)13,15,22 or extinct (Trigonioides tetoriensis).

The resemblance of the color patterns between the Kitadani Freshwater Bivalves and the extant unionids possibly resulted from the phylogenetic constrains. Each of the three species of the Kitadani Freshwater Bivalves belongs to a separate family (Trigonioides tetoriensis: Trigonioididae, Plicatounio naktongensis: Plicatounionidae, and Matsuomtoina matsumotoi: Pseudohyriidae) in the order Trigoniida19. Trigoniida in turn, forms the subclass Palaeoheterodonta with Unionida23. This raises a possibility that the color patterns observed in the Kitadani Freshwater Bivalves and the extant unionids is inherited from their most recent common ancestor. In other words, these color patterns, stripes along the growth lines and radial rays tapered toward the umbo, may be the apomorphy for Palaeoheterodonta. In fact, some extant trigoniid species belonging to Neotrigonia exhibit color pattern similar to those in the Kitadani Freshwater Bivalves and extant unionids in this study (e.g. Neotrigonia margaritacea)1.

Interestingly, the coloration of color patterns is quite different between unioniids (green to blue colorings) and trigoniids (red to yellow colorings), and the oldest known color patterns of the Palaeoheterodonta (Myophorella nodulosa, a marine species of Trigoniida from the Oxfordian of the Early Jurassic) appears different (concentric rows of patches)10 from those of the Kitadani Freshwater Bivalves or the extant unioniids. These observations suggest that colorations evolved independently, in contrast to the color patterns, between Trigoniida and Unionida, and that Trigoniida more diverse color patterns than Unionida did in the Palaeoheterodont evolutionary history. Although further examination of the fossil record for the residual colors and color patterns in Palaeoheterodonta is essential, it is plausible that the habitat differences may have caused such discrepancy in the colorations and color patterns between Trigoniida (mainly marine) and Unionida (freshwater) in spite of the phylogenetic constrains.

The other possible interpretation of the color pattern similarity between the Kitadani Freshwater Bivalves and extant Unionida, is the convergent evolution. One potential factor that may have caused this convergent evolution of the color patterns is an adaptation to their habitats. In general, much of the convergent evolution in animals occurs through the morphological evolution in response to their habitats24. Similarly in mollusks, shell colors and their patterns are generally influenced by their habitats2,6,25. Considering marine mollusks, the shell colors and their patterns have great diversity due to varying habitat environments, especially in coral reeves that exhibit various colors and complex ecosystem2,6. Conversely, in the freshwater ecosystem, the environmental colors are relatively monotonous with rocks, sand, mud, and green algae8, and such habitat conditions are likely indifferent between the Mesozoic and Cenozoic. As a result, the freshwater bivalves retained simple and monotonous color patterns for adapting to such environments throughout their evolution.

Another conceivable factor to explain the convergent evolution in the color patterns of the studied freshwater bivalves is the selection pressure by visual predators. In general, the shell colors and their patterns in bivalves act as camouflages against the predators2,7,8,26,27,28. Previous studies have demonstrated that extant freshwater bivalves are preyed upon by crayfish, fish, birds, reptiles, and mammals29,30. Because shell colors in freshwater bivalves tend to be greenish, such colors may be an adaptation against visual predators for blending into the freshwater sediments on which abundant greenish phytoplanktons occur2,8. Therefore, the evolutionary conservatism in color patterns of freshwater bivalves may result from camouflages into freshwater microenvironments, which has been advantageous against visual predators since the late Early Cretaceous.

The above discussion assumes that the visual predators of freshwater bivalves remained similar for at least 120 million years. Which animals could have been potential threads to the Kitadani Freshwater Bivalves, and, in turn, the Early Cretaceous freshwater bivalves? Among the extant visual predators of the freshwater bivalves, those whose lineages were present in the Early Cretaceous include crustaceans (especially brachyuran decapoda31), fish, lizards, turtles, crocodiles, birds, and mammals. Among them, the fossil record of durophagous lizards and mammals can be traced back only to the Late Cretaceous32,33. Conversely, lines of fossil evidence suggest that some fish34,35, turtles36, and crocodiles35 fed on molluscan invertebrates during the Early Cretaceous, and the Kitadani Freshwater Bivalves indeed occurs with abundant lepisosteiform scales, testudinate shells and crocodile teeth. Additionally, at least one Early Cretaceous avian species with crustacean gut contents can be attributed to the durophagous diet37, and the Kitadani Formation has yielded avialan skeletal remains38, and footprints39,40. Therefore, fish, turtles, crocodiles, and birds are likely candidates for visual predators of the Early Cretaceous freshwater bivalves, and have remained so until present. Additionally, while crustaceans have not been identified in the Kitadani Formation, they flourished in the Early Cretaceous and their remains occur with the fossil freshwater bivalves of the time elsewhere31. Thus, crustaceans may have also played a role as visual predators of the freshwater bivalves since the Early Cretaceous.

In addition to the crustaceans, fishes, turtles, crocodiles and birds, the visual predators of the Early Cretaceous freshwater bivalves likely include extinct lineages. For example, some pliosauroid plesiosaurs are suggested as being durophagous34, although the freshwater members of the group are considered endemic41 and less likely to be a major thread to the Early Cretaceous freshwater bivalves. Another extinct candidate is non-avian dinosaurs. Ornithischians are suggested to have possessed a dietary flexibility including the durophagy. For instance, well-preserved hadrosaurid coprolites from the Late Cretaceous of Montana, U.S.A. include sizeable crustaceans and mollusks, possibly suggesting that the Cretaceous freshwater mollusks were consumed by these herbivorous dinosaurs42. In addition, some basal ceratopsian psittacosaurids are hypothesized for the durophagy based on the predicted large bite force in the caudal portion of the toothrow43. Among saurischians, some oviraptorosaurian theropods are indicated to consume mollusks with hard shells based on their mandibular features44. While hadrosaurids, psittacosaurids, and oviraptorosaurians have not been identified in the Kitadani Formation, psittacosaurids, and oviraptorosaurians are common elsewhere in the Early Cretaceous of East Asia45,46, and hadrosauroid Koshisaurus is present in the formation47. Because dinosaurs occupied a niche of large terrestrial predators throughout the Mesozoic, they may have acted as one of major mollusk consumers in absence of large lizards and mammals in the Early Cretaceous ecosystem. Thus, the predation pressure by visual predators to the freshwater bivalves in the Early Cretaceous is likely similar to that in the present. Consequently, one of evolutionary adaptations of the freshwater bivalves against such pressure has remained to camouflage in the phytoplankton-rich sediments, leading to the long-term evolutionary conservatism of their color patterns.

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A New Study Will Change the Way We View Human Evolution – MeatEater

Posted: at 9:27 am

A new study out of South Africa could rewrite certain aspects of humankinds evolutionary origin story.

The study hinges on an innovative fossil aging technique called cosmogenic nuclide dating. It shows that the fossil record of an early human-like hominid called Australopithecus africanus stretches back 3.8 million years, making the species one million years older than previously thought.

The findings, published in the journal PNAS, are significant because they show Australopithecus africanus is just as old as a different hominid species called Australopithecus afarensis.

Au. afarensis was a type of bipedal hominin common to east Africa. The first skeleton of this species was unearthed in 1974 and is now known as the famous Lucy skeleton.

Since paleoanthropologist Donald Johannson exhumed Lucys remains, many scientists have pointed to the remains as the primary intermediary between modern-day humans and our ancient primate cousins. But these new findings make it harder to say, with any degree of certainty, that human beings evolved directly from Lucys species.

We found that Australopithecus africanus is in the same age range as Australopithecus afarensis, which is Lucys species in east Africa, the studys lead author Dr. Darryl Granger told MeatEater. Lucys species started showing up at about the same time, about 3.8 million years ago, but Lucy herself is 3.2 million years old, so these fossils weve dated are older than Lucy herself but not older than her species.

According to Granger, the two species of ancient bipedal hominids are contemporaries, meaning they emerged and existed around the same time.

People used to think about the [human family] tree as being very linear, meaning one species leads to another, Granger said. One of the traditional views is that Lucys species, afarensis, evolved into africanus in South Africa, but that cant happen because theyre the same age. They both have an older common ancestor, and they both showed up around the same time.

Granger has been working in Sterkfontein, South Africaa complex cave site known for its high concentration of Au. africanus remainson and off since the early 2000s. Around 2003, he started to suspect that the fossils there were much older than most anthropologists believed.

Before Granger made his discovery, the Au. africanus fossils of Sterkfontein were dated at only 2.1 to 2.6 million years old. That would have put them on the earth at the same time as the genus homo, which emerged around 2.8 million years ago. As a result, Au. africanus was ruled out as an early precursor to modern humans.

That narrative is shifting now, thanks largely to Grangers work, which relied on the more up-to-date cosmogenic nuclide dating method.

The method measures the amount of cosmic ray exposure in the sedimentary matrix that surrounds the Au. africanus fossils of Sterkfontein.

Cosmic rays originate in outer space, and they leave a traceable imprint on the earth's surface when they interact with certain elements. Once the remains of Au. africanus and the surrounding sediment were buried deep within the Sterkfontein cave complex they were no longer being exposed to cosmic rays. Granger and his team have determined the point when that cosmic ray exposure ceased, thus assigning the new age to Sterkfonteins Au. africanus fossils.

You can think about the cosmogenic nuclides kind of like a sun tan, Granger said. The longer youre exposed, the darker you get. And then if you go inside and stay inside for months, your tan fades away. The same thing happens to these rocks if they get washed into a cave. Whatever they built up at the surface decays away by radioactivity, so you can see how much is left after theyve been buried and figure out how long theyve been in a cave.

While Grangers work updates our understanding of the age and origin of the Au. africanus speciesand increases the likelihood that africanus is in fact one of our earliest ancestorsit doesnt change what we know about the bipedal hominids day-to-day life.

According to Granger, the species wasnt known for using stone tools. While it may have relied on insects and small animals to supplement a fruit, root, and grass-heavy diet, africanus didnt eat meat on a regular basis or engage in organized hunting.

They would have been eating a lot of different things that were around in their environment but mostly plants, he said. The big transition to relying on meat and marrow was later, when you see the transition from australopithecus to homo. Thats when the brains expanded, and you started seeing stone tools probably used for processing animal carcasses, for getting at bone marrow inside the bones, which is really energy-rich.

The evolution from australopithecus to homo, and the corresponding leap in brain size, was driven by the adoption of meat-rich diets, Granger said. Compared to human brains, the brains of the australopiths were relatively smallmore akin to that of a modern chimpanzee.

As for his most recent finding, Granger said that much of the feedback hes received so far has been supportive. But because the study is still so new and its implications so significant, hes anticipating some criticism and resistance from the broader scientific community.

Ive been working in Sterkfontein before, and theres been some resistance to earlier aging from deeper in the cave. People can come up with scenarios where youve got young fossils in old sediment, but that doesnt work here, he said. This paper, in a way, is a response to that resistance, and its reinforcing the idea that these [South African] australopithecines are old. I welcome criticism and other people working at the site. Thats the way science happens. We all try to poke holes in each others work. Its part of the process. Well wait and see.

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