Monthly Archives: June 2022

Agingis a complex biological process regulated by multiple intrinsic and extrinsic factors such as genetics, epigenetics, environment, lifestyle, and immune response. Aging is often defined as an age-related deterioration of physiological and cognitive functions necessary for survival and reproduction.

During aging, the brain undergoes various morphological, cellular, molecular, and functional changes leading to the occurrence of age-related cognitive decline. Healthy elderly people showsignificant decreases in brain volumeand experience mild cognitive impairment (i.e. working memory & executive function) compared with younger adults. In patients with Alzheimers disease or other types of age-related dementia, thecognitive impairmentis significantly more severe affecting daily life activities and requiring medical/professional assistance.

The idea of aging is something that is commonly feared by many, but what if it didnt hurt to grow old? Imagine living independently longer. Less severe dementia. Later onset of cancer. Healthier heart and kidneys for longer. Klotho, a natural human protein has great potential to delay these diseases of aging. Loss of cognition, kidney failure, diabetes, and cancer are all things that are believed to be associated with the bodys production of this Klotho protein. Klotho Therapeutics (KTI) is using biotechnology to mimic the human protein.

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Klotho Protein for Longevity - Delay Dementia, Kidney Disease & Cancer

A new study looking at creatures such as tortoises and turtles has found that theyhave biological mechanisms that slow down or even completely switch offageing, which may indicate a way to extend human longevity.

As reported by The Independent,the research, published in thejournalScienceon Thursday, looked at signs of senescence the gradual process of deterioration of physical and functional characteristics among tortoises and turtles living in zoos and aquariums.

The international team of scientistsfound that the pattern of ageing in these cold-blooded creatures does not resemble that seen in humans or other animals.

Most of the studied creatures aged slower, and in some cases, their senescence is negligible, scientists said.

Creatures that were studied included77 cold-blooded species from 107 wild populations, including turtles, amphibians, snakes, crocodilians and tortoises.

Species of tortoise were found to have less senescence (Canva)

Of the 52 species analysed in the study, scientists said three-fourths of them showed extremely slow senescence, while 80%appeared to have slower ageing than modern humans.

Some of the species have the ability to reduce their rate of ageing in response to the improved living conditions in zoos and aquariums, compared to the wild, scientists say.

Theories around senescence suggest that it begins after sexual maturity, where it invests more energy in reproduction than in repairing cells and tissue.

Due to this tradeoff, researchers have held that after reaching sexual maturity, individuals inevitably stop growing and start experiencing senescence a prediction that has been confirmed for several species, particularly mammals and birds.

Turtles and tortoises, and other organisms that keep growing after sexual maturity, could have the ability to keep investing in repairing cellular damages - which then avoid the effects of senescence.

Although humans have witnessed unprecedented increases in longevity in the last century, scientists say improved living conditions does not modify the rate of ageing in humans and other primates.

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The slow ageing of tortoises could unlock secrets to human longevity, says study - HeraldScotland

Longevity Investors Conference (LIC) returns for its third annual edition from Sept. 2830 in Gstaad, Switzerland.

The conference attracts the worlds top longevity leaders, institutional and private investors, wealthy private investors and family offices and funds in an exclusive setting. For two days, opinion leaders and high-ranking representatives will exchange their knowledge about longevity, trends, attractive investments and business opportunities in the longevity space. The conference will ensure a private atmosphere and the opportunity to establish partnerships with other business leaders and investment opportunities in a unique setting at Le Grand Bellevue, a five-star hotel in Gstaad and one of the most exclusive Swiss mountain resorts.

The LIC has the honor of welcoming leading longevity experts and scientists, such as Harvard Medical School genetics professor George Church, SENS Research Foundation chief of science offices Aubrey de Grey, Buck Institute for Research on Ageing president and CEO Eric Verdin, Institute for Ageing Research at Albert Einstein College of Medicine director Nir Barzilai, Forever Healthy Foundation founder Michael Greve, Human Longevity Inc. associate professor, internal medicine specialist and longevity physician Evelyne Yehudit Bischof, Insilico Medicine founder and CEO Alex Zhavoronkov, First Longevity founder and Longevity.Technology editor-in-chief Phil Newman, and Wei-Wu He, Human Longevity Inc. executive chairman, Casi Pharmaceuticals Inc. CEO and chairman, and Genetron Health founder and chairman.

More speakers will be announced closer to the conference.

LIC was initiated by Tobias Reichmuth and Marc Bernegger, two successful serial entrepreneurs who, among others, launched CfC St. Moritz, one of the most exclusive conferences for digital assets.

Keynote speeches, fireside chats, panel discussions and breakout sessions on topics including biotech, aging technology, diagnostics, AI, health prevention, longevity therapy and investment strategy await the attendees of the 2022 conference.

The conference is in the Bellevue Hotel in Gstaad, recently rated Hotel of the Year by the Swiss media. The hotel will be privatized for LICs guests, ensuring an exclusive networking experience. Some of the conferences partners include PricewaterhouseCoopers, Credit Suisse, Maximn, Korify Capital, Apollo Health Ventures, Clinique La Prairie, Biolytica AG, Avea Solutions and many more.

The unique event format combines rich content and insight-sharing during the day, with numerous opportunities to recharge and network at the lunches, evening receptions, dinners and longevity experiences occurring during the course of the two-day conference.

There are more and more traditional investors joining the longevity space, which creates massive investment opportunities. The special setup of this years conference enables not only knowledge exchange but also effective community-building, which is very unique for the industry and has never happened before to this extent, said Marc Bernegger, one of the driving forces behind the conference.

Tobias Reichmuth, co-founder of LIC and Berneggers partner, said, The longevity industry will be one of the biggest investment opportunities during the next decade expected to be worth at least $600 billion by 2025. It is experiencing great momentum, and this is the ideal time to use it in favor of educating and spreading information to investors. In a sea of science-oriented conferences, a professional and global investor-focused longevity conference such as LIC will provide an opportunity for the industrys top investors and innovators to get acquainted with recent developments and breakthroughs.

Early bird tickets are available until the end of June on the site.

Link:
Longevity Investors Conference to be held in Gstaad, Switzerland Sept. 2830 - Cointelegraph

Berlin/Germany, June 23, 2022 TheRejuvenation Startup Summit(Berlin, Oct. 14-15, 2022) is a vibrant networking event that brings together startups and members of the longevity venture capital/investor ecosystem all aiming to create therapies to vastly extend the healthy human lifespan. Rejuvenation/Longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself.

In addition to an exciting range of presentations from CEOs of startups in the field of rejuvenation/longevity, the summit features an all-day startup forum for vibrant networking. Starting midday on Friday and finishing off on Saturday night with a big party, it offers ample opportunity to get in touch, learn and network with some of the most promising companies in the field like:

Investors may explore concrete investment opportunities, or if new to the field, get jumpstarted on the upcoming new megatrend Rejuvenation/Longevity a still young industry that will eventually become much bigger than todays largest technology markets.

Early Bird pricing for theRejuvenation Startup Summit (Oct 14-15) ticketsstays effective till Thursday, 21 of July, 12:00 pm CET (03:00 am Pacific).

The Rejuvenation Startup Summit (Berlin, Oct. 14-15, 2022) hosted by the Forever Healthy Foundation, is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry.

Rejuvenation/Longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself.Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification, tissue stiffening, loss of stem cell function, genetic alterations, and impaired energy production.

The Summit brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in founding or joining a startup all aiming to create therapies to vastly extend the healthy human lifespan.

Further information can be found atwww.forever-healthy.org/summit.

Frank Schueler, Chief Operating Officer

[emailprotected]

Excerpt from:
The Rejuvenation Startup Summit Speakers - Lifespan.io News

Express News Service

HYDERABAD: Ageing of the immune system is becoming a matter of concern, more so, amid the pandemic. But what does immune ageing even mean? Is that a concern for just the researchers or us too? For answers to these and more, experts explain it all to CE. Dr G Navodaya, consultant, general medicine, Care Hospitals, Banjara Hills, feels that immune ageing has a wider perspective and says, Immune ageing is a phenomenon that occurs in any patient who is ageing, so this is not specific to immunity.

The human body has many cells with unique responsibilities. Some keep the person alive, others build muscle structure, and some maintain the functions of the body, etc. Now, every cell has a basic function and age and after a certain function and time, the cells die. Immunity ageing is the same if a person is ageing, meaning, growing older, they are likely to see physical changes in and outside the body. Similarly, cell functions start to reduce inside the body, eventually. Cells that maintain our immunity to help fight infections too meet the same fate.

So what does this mean for us? He responds, Immunity is maintained so as to protect us from infections. But when these cells have less strength then the human body is prone to infections. He adds that immune ageing happens not just when one turns older but the process is fastened if habits like smoking and drug intake grow.

Dr Jagadeesh Kumar V, consultant physician at KIMS Hospital, Secunderabad, says that when one bears the brunt of too many infections, the immune cells in the body take a hit. The advent of Covid has worsened this fear. Immune ageing, which is otherwise called inflammaging, points that inflammation in our body is growing or ageing. Every time a body undergoes inflammation or infection, peoples immunity ages. The cells lose their functional capacity once a person is infected, says he.

Talking about the aftermath of this, he says, people become obese, theyre vulnerable to infection, their cognition declines (memory comes down), comprehensive capacity and capability come down, etc. On a concluding note he adds that stress too, is a catalyst for immune ageing. Lack of sleep, unhealthy lifestyle lead to stress, which is making many prone to immune ageing and thus, to many diseases, he cautions.

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Your immunity has a life span - The New Indian Express

Abdulla Shahid, President of the 76th session of the United Nations General Assembly (UNGA) has urged communities across the globe to protect the ocean and ensure its health and longevity.

He said this in his remarks at the opening ceremony of the 2022 UN Oceans Conference on Monday, where he spoke extensively on the concrete, demonstrable action required to underscore the commitment to save the ocean, to protect it against the threats - both human-driven and otherwise - that would take it away from us.

The PGA noted that the ocean being an essential part of life on this planet is an inescapable reality for him as a person and as a Maldivian, adding that for small islanders, coastal residents, workers dependent on tourism and coral reefs, fisherpersons and for all those who turn to the ocean for livelihood, for reprieve, and for enjoyment, this reality rings true.

I am a Maldivian. Whether I am here as President of the General Assembly or not, the ocean is in my blood; it runs through my lifes narrative, from childhood to parenthood; from my career in the Foreign Service to my Parliamentary experience, to what I represent today. I am from a large ocean State. I am a child of the ocean.

Abdulla Shahid, PGA.

Highlighting that beyond those who look to the blue horizon each day, the entirety of humanity relies upon the ocean for half of the oxygen that people intake, the PGA said that the ocean connects communities across the globe.

He added that the ocean connects humanity and the planet, adding that there is no context communities across the globe can live without it.

Stressing that the ocean conference came at a critical and timely opportunity, Shahid noted that on one hand the ocean faces countless threats from climate change to plastic pollution and from over-fishing to acidification and that on the other hand there is momentum.

In this regard, on Friday, we will adopt a declaration, that will give direction and set the tone for our future work. I was pleased to reappoint the Permanent Representative of Grenada, Ms. Keisha McGuire, and Permanent Representative of Denmark Mr. Martin Hermann, for this task. And I commend them and their experts Nerissa Williams and Mira Bergem, for delivering! And thank all Member States for their commitment.

Abdulla Shahid, PGA.

PGA Shahid stated that the 40th anniversary of the UN Convention on Law of the Sea has reiterated the shared responsibility for the ocean, adding that recent efforts such as the landmark agreement on ending plastic pollution and the new World Trade Organization deal on fisheries subsidies, gives cause for hope.

Further, Shahid said that there is optimism towards an international legally binding instrument on the conservation and sustainable use of marine biological diversity of areas beyond national jurisdiction.

He noted that solid partnerships across all stakeholders are being established and strengthened, as observed at the Our Ocean Conference in Palau earlier this year.

With this being said, he highlighted how there is a strong foundation to build upon and how the ocean conference can set the tone for what needs to be done.

PGA Shahid urged the global communities to not fall prey to shortsightedness or lack of ambition, to invest in, trust in, and act upon science.

Shahid, who also serves as the Minister of Foreign Affairs of Maldives, also urged the people to protect the ocean, leverage its power, relish its beauty, cherish its diversity and ensure its health and longevity in order to save it.

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PGA urges to protect the ocean, ensure its health and longevity - Raajjemv

The market for wearable technology has grown a lot in the last ten years, with fitness and health tracking features being the main USP of most such devices in the market.

Googles 2021 acquisition of Fitbit for over $2 billion was their entry into the wearables market. Since then, the Pixel Watch has also entered the ring, with revolutionary new features.

Aside from the basic features like counting steps taken or calories burned, there are also new technologies being introduced like a sensor that can detect irregularities in the wearers pulse.

This sensor has recently received FDA approval, The Economist reports. Googles Pixel phone cameras can detect heart blood oxygen levels using image processing and their smart home devices can monitor sleep patterns by listening to snoring.

Apple is another strong player in this arena, with their whole arsenal of fitness and health tracking features on the Apple Watch and iPhone.

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Big Tech Dives into Healthcare With Google Parent Alphabet at the Forefront - The Quint