Daily Archives: May 17, 2022

Emendo Biotherapeutics’ next generation CRISPR gene editing technologies achieve breakthrough results with allele-specific approach for ELANE-related…

Posted: May 17, 2022 at 7:15 pm

NEW YORK--(BUSINESS WIRE)--Emendo Biotherapeutics presented the results of its next generation CRISPR-based gene editing approaches for several indications in an oral presentation and three posters at the 25th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) held May 16-19, 2022, in Washington, D.C.

Emendo presented pre-clinical data for the treatment of ELANE-related Severe Congenital Neutropenia using an allele-specific editing approach, demonstrating the power of Emendos dual technology platforms that enable the development of a highly specific editing composition that demonstrates no off-targets and complete allele specificity. Significantly, the lack of off-target achieved by Emendos engineered and optimized OMNI nuclease also eliminated any translocations. Edited patient derived CD34+ cells differentiated normally into neutrophils both in-vitro and in-vivo, showing full engraftment and reconstitution of all blood lineages, as required for the desired therapeutic effect.

ELANE-based Severe Congenital Neutropenia, Emendos lead indication, is a devastating disease affecting pediatric patients that until now has been incurable, said David Baram, Ph.D., President & CEO of Emendo Biotherapeutics. We are excited by the potentially curative treatment developed by our team and were pleased to present our pre-clinical results for this program and other diverse applications of our dual gene editing technology platforms at this years ASGCT meeting. And of course, we look forward to the discussion generated by our discoveries around Type II CRISPR nuclease classifications that promise to be ground-breaking in the field.

Senior members of the Emendo Biotherapeutics R&D team including Chief Technology Officer Lior Izhar, Ph.D. and Executive Vice-President Research & Development Rafi Emmanuel, Ph.D. presented Emendos research on-site at the conference.

Session Presentation

Title: A Novel Engineered CRISPR-Associated Nuclease Accurately Removes ELANE Mutated Allele and Shifts HSC Differentiation Towards Neutrophils in Severe Congenital Neutropenia

Session Title: Gene Therapy for Immunologic DiseasesSession Date/Time: Tuesday May 17, 2022 3:45 PM - 5:30 PMPresentation Time: 3:45pm - 4:00pmRoom: Room 202Final abstract number: 482

Poster Presentations

Title: A Unique CRISPR-Based Nuclease with a Non-NGG PAM Efficiently Targets Multiple Exclusive Genomic Sites for Immuno-Oncology Based Therapy

Session Title: Cancer - Targeted Gene and Cell Therapy ISession Date/Time: Monday May 16, 2022 5:30 PM - 6:30 PMPoster Board Number: M-215Room: Hall DFinal abstract number: 334

Title: CRISPR-Based Gene Editing Enhances LDLR Expression and Boosts LDL-C Uptake in Familial Hypercholesterolemia

Session Title: Metabolic, Storage, Endocrine, Liver and Gastrointestinal Diseases IISession Date/Time: Wednesday May 18, 2022 5:30 PM - 6:30 PMPoster Board Number: W-125Room: Hall DFinal abstract number: 999

Title: Challenges and Inconsistencies in Type II CRISPR-Associated Nuclease Subtype Classification

Session Title: Gene Targeting and Gene Correction IISession Date/Time: Tuesday May 17, 2022 5:30 PM - 6:30 PMPoster Board Number: Tu-61Room: Hall DFinal abstract number: 556

About Emendo Biotherapeutics

Emendo Biotherapeutics, a subsidiary of AnGes, Inc., is a next generation CRISPR gene editing company leveraging dual proprietary technology platforms to enable high precision gene editing throughout the genome. Emendos novel nuclease discovery platform broadens the targetable range of the genome while its target-specific optimization platform enables highly precise editing, including allele specific editing, while maintaining high efficiencies. The capabilities of the OMNI technology platforms, along with deep expertise in genomic medicine, protein engineering and therapeutic development, provide Emendo with a unique advantage when addressing indications within hematology, oncology, ophthalmology and other disease areas. For more information please visit http://www.emendobio.com.

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Latest Human Cells Atlas reveals more of the unknown world inside our bodies – EL PAS in English

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In the latest version of the Human Cells Atlas, 2,000 researchers in 83 countries have defined, one by one, some 60 million cells.

Our mission is to create a map of all human cells, says Israeli biologist Aviv Regev, who began the project in 2016 and leads the international consortium together with the German biologist Sarah Teichmann, from the Wellcome Sanger Institute in Cambridge (UK).

Regev, who is on leave from the Massachusetts Institute of Technology (MIT) and has a management position at US biotech company Genentech, says she believes the cross-continental team is halfway to its goal.

While children study some examples of cells at school such as neurons, red blood cells, white blood cells, and platelets, nobody knows how many types there really are, explains the scientist.

We didnt know how many genes we had until the Human Genome Project. This is a similar case, she says.

The Human Cells Atlas aims to catalog all cell types and their multiple subtypes, but also to locate them precisely in the human body and have a picture of the exact composition of each organ: what we are made of and why diseases arise.

Spanish immunologist Cecilia Domnguez Conde is among the main authors of the latest version, which was reported last week in the journal Science. The researchers describe the detailed profile of more than a million cells; presenting cross-referenced data from 33 organs of the human body, such as the heart, skin and lungs.

Domnguez Condes team is based at the Wellcome Sanger Institute, and has focused on the cells of the immune system.

We have discovered how cells adapt to different environments, says the immunologist, who will begin leading her own laboratory at the Human Technopole, a new research center in Milan (Italy), in June.

The diversity of cell types within the immune system is absolutely incredible, says Domnguez Conde, adding that the work had previously focused on the blood circulating in the body, while now, we study the cells in different tissues and we see new mechanisms.

The immunologist notes that there is a new generation of cancer treatments, the so-called CAR-T, in which white T lymphocyte blood cells are extracted from the patient. Then, using genetic engineering, they are redesigned in the laboratory to increase their ability to destroy cancer cells.

Biology textbooks have traditionally spoken of about 300 cell types in the human body, but the authors of the atlas have found 500 types in the last million cells analyzed. Understanding this astonishing diversity will make it possible to improve vaccines, increase the efficacy of antitumor therapies, facilitate regenerative medicine and develop new treatments for rare and common diseases, according to Regev, who now has a management position at the US biotech company Genentech.

While biology textbooks usually teach that there are about 300 cell types in the human body, the authors of the Human Cell Atlas have now found some 500 types. This new understanding, says Aviv Regev, will contribute to improving vaccines and antitumor therapies as well as regenerative medicine and new treatments for both rare and common diseases.

A mutation in a gene can cause a disease, but although all cells share the same DNA, the problem will only appear in cells that have that particular gene activated.

We have found many unexpected cells that have active disease-associated genes, says Regev.

For example, we have observed non-muscle cells in muscle tissue expressing genes that cause rare muscle diseases.

This is important, because if we want to develop treatments we need to know the cells in order to target them, explains the biologist.

Regev also highlights possible applications of these findings to regenerative medicine, a specialization that tries to rebuild damaged organs using new cells.

To get it right, we need to generate cells with the right properties. The atlas is a reference to ensure that the cells generated in the laboratory have the desired characteristics, he says.

Neuroscientist Rafael Yuste, a professor at Columbia University in New York, applauds the latest version of the atlas.

This batch of results is historic. It is one of the first salvos of what will be a torrent of studies in the next decade that will classify all cell types in the body, says Yuste, who has not participated in the investigation. The Spanish neuroscientist was the founder of BRAIN, a billion-dollar project sponsored in 2013 by then-US president, Barack Obama, to obtain a map of the human brain.

Yuste is optimistic. The new technologies, called transcriptomics, allow cells to be placed in narrow channels and trapped one by one in oily droplets, analyzing their active genes in a manner that is fast, automated and cheap.

The first steps of this strategy have been spectacular. For example, in the United States, the Allen Institute of Brain Sciences has classified all the cells in a part of the cerebral cortex of the mouse, generating for the first time a list of all the types of neurons in an area of the brain, says Yuste, who has collaborated on that project.

Yuste recalls how the father of neuroscience, Santiago Ramn y Cajal, discovered in 1888, using a rudimentary microscope, that neurons were individual cells. Now, says Yuste, it is giant consortia like his BRAIN initiative and the Human Cell Atlas doing this work.

It is a huge effort, says the professor. It will have a fundamental impact on science and medicine, since, in the end, everything that the brain, or the body, does, is cooked up between cell types.

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Middle-East precision medicine market was estimated to be at $3,942.6 million in 2021, which is expected to grow with a CAGR of 7.37% and reach…

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ReportLinker

Middle East Precision Medicine Market to Reach $8,620. 0 Million by 2032. Middle East Precision Medicine Market Industry Overview. The Middle East precision medicine market was estimated to be at $3,942.

New York, May 17, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Middle East Precision Medicine Market - Country Analysis: Focus on Ecosystem, Technology, Application, End User, and Country Data - Analysis and Forecast, 2022-2032" - https://www.reportlinker.com/p06277485/?utm_source=GNW 6 million in 2021, which is expected to grow with a CAGR of 7.37% and reach $8,620.0 million by 2032. The Middle East precision medicine market is expected to witness high growth, attributed to the rising prevalence of chronic disease, advancement of sequencing technologies, reducing adverse drug reactions through pharmacogenomics tests, and potential to reduce the overall healthcare cost across the globe. The continued significant investments by healthcare companies to meet industry demand and the growing adoption of precision medicine among major end users are the major factors propelling the growth of the Middle East precision medicine market.

Market Lifecycle Stage

Precision medicine refers to the medicine developed as per an individuals genetic profile.It provides guidance regarding the prevention, diagnosis, and treatment of diseases.

The segmentation of the population is done depending on the genome structure of individuals and their compatibility with a specific drug molecule.In the precision medicine market, the application of molecular biology is to study the cause of a patients disease at the molecular level so that target-based therapies or individualized therapies can be applied to cure the patients health-related problems.

This industry is gaining traction owing to the growing awareness about healthcare among individuals, the integration of smart devices such as smartphones and tablets into healthcare, and the increasing collaborations and agreements of information technology (IT) firms with the diagnostics and biopharmaceutical companies for the development of precision diagnostic tools.The growth of the precision medicine market over the last few years has been monumental.

New technologies are rapidly being introduced, expanding the arsenal of tools accessible to support the development and adoption of precision medicine solutions over one-size-fits-all therapies. Advancements in gene therapies, cell therapies, molecular biomarker analysis, and companion diagnostics have the potential to transform medicine and increase the ability to treat and cure several intractable diseases. Advances in sequencing technologies and non-invasive diagnostics, such as liquid biopsy and non-invasive prenatal testing (NIPT), have facilitated the acquisition of real-time data and gained interest for their usage in acquiring the data by exhibiting the biology of tumors and metastatic tissues.

Impact

The presence of major service providers of precision medicine products in Middle East regions has a major impact on the market. For instance, Illumina, Inc. provides NovaSeq 6000 S2, Reagent Kit, NovaSeq 6000 S4 reagent kit, and NovaSeq Xp 4-lane kit in the Middle East. Companies such as F. Hoffmann-La Roche Ltd provide foundation one liquid. The services are a reliable and convenient way to expand in-house resources with expertise and perfectly tailored bioinformatics services that ensure quality results. The presence of these companies has a positive impact on market growth.

Impact of COVID-19

The current Middle East precision medicine market study comprises products and applications utilized to provide beneficial effects to specific health benefits and treatments.Since the market is primarily application and ecosystem-dominated, the COVID-19 pandemic had a low impact on the growth or the revenue generated from the market.

The current market assessment has considered information provided by key opinion leaders in the market, from the supply side as well as the demand side.A majority of the products, such as kits and assays in the market, are used for infectious disease applications.

In addition, infectious diseases are playing an important role in the growth of the market.

Market Segmentation:Segmentation 1: by Ecosystem Applied Sciences Precision Therapeutics Digital Health and Information Technology Precision Diagnostics

The Middle East precision medicine market is expected to be dominated by the precision therapeutics segment. This is due to an increasing number of drugs or therapeutics offered to their end users.

Segmentation 2: by Application Oncology Infectious Diseases Neurology Endocrinology Cardiology Gastroenterology Others

The Middle East precision medicine market is dominated by the oncology segment owing to an increasing number of patients suffering from cancer. According to the data published by World Health Organization, cancer is a leading cause of deaths, with nearly 10 million deaths reported in 2020.

Segmentation 3: by End User Biopharmaceutical Companies Diagnostic Companies Others

Segmentation 4: by Region Middle East - K.S.A., Israel, Egypt, United Arab Emirates (U.A.E.), Iran, Qatar, Other Countries

Kingdom of Saudi Arabia (K.S.A.) generated the highest revenue of $1,059.7 million in 2021, which is attributed to the R&D advancements in the field of single-cell analysis and the presence of dominating players operating in the precision medicine market.

Recent Developments in Middle East Precision Medicine Market

In October 2020, Bio-Rad Laboratories launched the CFX Opus 96 Dx System and CFX Opus 384 Dx System. The product can multiplex near about five samples to offer effective in-vitro diagnostics (IVD) assay development and testing. The product has been commercialized in the Middle East region. In March 2021, F. Hoffmann-La Roche Ltd released the AVENIO Tumor Tissue CGP Kit, which enables laboratories to extend their oncology research in-house. In June 2019, F. Hoffmann-La Roche Ltd partnered with the Health Authority and an international health insurer, AXA, in Dubai. This partnership would develop funding for diagnostic and treatment for breast, colorectal, and cervical cancers.

Demand Drivers and Limitations

Following are the demand drivers for Middle East precision medicine market: Advancement of Sequencing Technologies Rising Prevalence of Chronic Diseases Shifting the Significance in Medicine from Reaction to Prevention Reducing Adverse Drug Reactions through Pharmacogenomics Test Potential to Reduce the Overall Healthcare Cost Across the Globe

The market is expected to face some limitations too due to the following challenges: Unified Framework for Data Integration Limited Knowledge about Molecular Mechanism/Interaction Lack of Robust Reimbursement Landscape

How Can This Report Add Value to an Organization?

Ecosystem/Innovation Strategy: The ecosystem segment helps the reader understand the four types of products, i.e., applied sciences, precision therapeutics, digital health and information technology, and precision diagnostics. These ecosystems are the major focus of the study as these are the target of market players in terms of revenue generation. Moreover, the study provides the reader with a detailed understanding of the different applications such as oncology, immunology, NIPT, microbiology, and others.

Growth/Marketing Strategy: The Middle East precision medicine market has been dominated significantly by companies such as QIAGEN N.V., PerkinElmer, Inc., F. Thermo Fisher Scientific Inc, and Hoffmann-La Roche Ltd., due to their expansive portfolio and strong presence across the world. The following figure represents the growth-share matrix for some of the major players in the Middle East precision medicine market based on their activities till the end of 2020. Many companies such as Agilent Technologies, Inc., Thermo Fisher Scientific Inc., PerkinElmer, Inc., Beckman Coulter, Inc. (Danaher Corporation), Illumina, Inc., Norgen Biotek Corp., and Omega Bio-tek, Inc. lie in the low growth and low market share segment. Most of the key market players in the Middle East precision medicine market are categorized under the low growth and low market share segment. The low market share of these companies is primarily due to limited products with respect to the Middle East precision medicine market in comparison to other segments of these companies. Also, the lack of synergistic activities with respect to the market is responsible for the low growth of these companies.

Competitive Strategy: Key players in the Middle East precision medicine market analyzed and profiled in the study have involved the precision medicine application-based product manufacturers that provide precision therapeutics and diagnostics.Moreover, a detailed competitive benchmarking of the players operating in the Middle East precision medicine market has been done to help the reader understand how players stack against each other, presenting a clear market landscape.

Additionally, comprehensive competitive strategies such as partnerships, agreements, and collaborations will aid the reader in understanding the untapped revenue pockets in the market.

Key Market Players and Competition Synopsis

The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing company coverage, product portfolio, and market penetration.

Some of the prominent names established in this market are: Abbott Bio-Rad Laboratories, Inc. ASURAGEN, INC. bioMrieux SA Diginova Health Solutions Ltd. F. Hoffmann-La Roche Ltd Diginova Health Solutions Ltd. GlaxoSmithKline plc. Illumina, Inc. Intomics Merck KGaA Novartis AG Thermo Fisher Scientific Inc.

Companies that are not a part of the above-mentioned pool have been well represented across different sections of the report (wherever applicable).

Countries Covered K.S.A. Israel U.A.E. Egypt Iran QatarRead the full report: https://www.reportlinker.com/p06277485/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Solution to Schrdinger’s Cat Problem Proposed in New Paper – University of Arkansas Newswire

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Art Hobson

FAYETTEVILLE, Ark. A paper recently published in the journal Quantum Engineering proposed a solution to a long-standing problem in quantum physics, popularly known as the Schrdinger's Cat problem. The paper, "Entanglement and the Measurement Problem," was authored by emeritus professor of physics, Art Hobson.

Schrdinger's Cat is a long-standing thought experiment used to explain the seemingly paradoxical state of quantum superposition, in which, for example, an atom is said to be both decaying and not decaying at the same time. The thought experiment begins when one imagines surrounding this atom with a measurement device that can detect an emitted particle.The device could, for instance, be a Geiger counter that will click when the particle hits it.According to quantum physics, this changes things. The atom is no longer said to be in a superposition of decaying and not decaying, but "entangled" with the detector.This entanglement appears to describe a detector that is both clicked and not clicked.

That said, physicists know that a large object like a Geiger counter cannot be in a superposition of clicking and not clicking. Erwin Schrdinger, one of the inventors of quantum physics, dramatized this by imagining that the detector is connected with a cat in such a way that, when the detector clicks, the cat dies. The cat effectively becomes the detector.Quantum physics then seems to imply that the atom plus cat entanglement describes a cat that is both dead and alive an example of the long-standing "measurement problem."

Hobson's paper examines entanglement by studying experiments conducted in 1990 at the purely microscopic level.In these experiments, two photons are entangled with each other. This entangled situation is identical mathematically with the atom plus detector entanglement, but the entirely microscopic nature of the two-photon system allows experimenters to manipulate the system in ways that would be impossible if one of the objects were a detector.

The implication of this, Hobson argues, is that entanglement is not what was previously thought, which was that the Schrdinger's cat entanglement predicted an undecayed nucleus and a live cat that are superposed with a decayed nucleus and a dead cat.He argues the experiments show that the theory predicts an undecayed nucleus that is correlated with a live cat, and a decayed nucleus that is correlated with a dead cat. Thus, the entangled state says the following:the nucleus is undecayed whenever the cat is alive, and the nucleus is decayed whenever the cat is dead. Hobson concludes that this solves the measurement problem.

Hobson retired in 1999 after 35 years of teaching. He has spent most of his time since retirement studying the foundations of quantum physics. He is a fellow of the American Physics Society. In 2006, he received the Robert A. Millikan Award, given by the American Association of Physics Teachers to members who have made notable and creative contributions to the teaching of physics. Since retirement, he has authored several research papers and a book on the foundations of quantum physics.

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Physicists Found a Way to Trigger The Strange Glow of Warp Speed Acceleration – ScienceAlert

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Every time you take a step, space itself glows with a soft warmth.

Called the FullingDaviesUnruh effect (or sometimes just Unruh effect if you're pushed for time), this eerie glow of radiation emerging from the vacuum is akin to the mysterious Hawking radiation that's thought to surround black holes.

Only in this case, it's the product of acceleration rather than gravity.

Can't feel it? There's a good reason for that. You'd need to move at an impossible speed to sense even the weakest of Unruh rays.

For now, the effect remains a purely theoretical phenomenon, far beyond our ability to measure. But that could soon change, following a discovery by researchers from the University of Waterloo in Canada and the Massachusetts Institute of Technology (MIT).

By going back to basics, they've demonstrated there could be a way to stimulate the Unruh effect so it can be studied directly under less extreme conditions.

In an unexpected twist, they might also have uncovered the secret to turning matter invisible.

The real prize, however, would be breaking new grounds in experiments that aim to unite two powerful but incompatible theories in physics one that describes how particles behave, the other covering the curving of space and time.

"The theory of general relativity and the theory of quantum mechanics are currently still somewhat at odds, but there has to be a unifying theory that describes how things function in the Universe," says mathematician Achim Kempf from the University of Waterloo.

"We've been looking for a way to unite these two big theories, and this work is helping to move us closer by opening up opportunities for testing new theories against experiments."

The Unruh effect sits right on the boundary of quantum laws and general relativity.

According to quantum physics, an atom sitting all alone in a vacuum would need to wait for an incoming photon to ripple through the electromagnetic field and give its electrons a jiggle before it could consider itself illuminated.

If we consider relativity, there is a way to cheat. Simply by accelerating, an atom could experience the smallest of wobbles in the surrounding electromagnetic field as low-energy photons, transformed by a kind of Doppler effect.

This interaction between the relative experience of waves in a quantum field and the jiggle of an atom's electrons relies on a shared timing in their frequencies. Any quantum effects that don't rely on timing are usually ignored, given on paper they tend to balance out in the long run.

Together with colleagues Vivishek Sudhir and Barbara Soda, Kempf showed that when an atom is accelerated, these usually negligible conditions become far more significant, and can actually take over as dominant effects.

By tickling an atom in just the right way, such as by using a powerful laser, they showed it's possible to make use of these alternative interactions to make moving atoms experience the Unruh effect without the need for large accelerations.

As a bonus, the team also found that given the right trajectory, an accelerating atom might turn transparent to incoming light, effectively suppressing its ability to absorb or emit certain photons.

Sci-fi applications aside, by identifying ways to influence an accelerating atom's ability to engage with ripples in a vacuum, it's possible we might be able to come up with new ways to find where quantum physics and general relativity give way to a new theoretical framework.

"For over 40 years, experiments have been hindered by an inability to explore the interface of quantum mechanics and gravity," says Sudhir, a physicist from MIT.

"We have here a viable option to explore this interface in a laboratory setting. If we can figure out some of these big questions, it could change everything."

This research was published in Physical Review Letters.

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Chien-Shiung Wus work defied the laws of physics – Popular Science

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The annals of science journalism werent always as inclusive as they could have been. SoPopSciis working to correct the record withIn Hindsight, a series profiling some of the figures whose contributions we missed. Read their stories and explore the rest of our 150th anniversary coveragehere.

In quantum physics, theres a law known as the conservation of parity, which is based on the notion that nature adheres to the ideal of symmetry. In a mirror-image of our world, it posits, the laws of physics would function the same waydespite everything being flipped. Since the early 1900s, experimental evidence suggested that this was true: To the pull of gravity or the draw of the electromagnetic force, the difference between left and right hardly mattered. So, physicists quite reasonably assumed that parity was a fundamental principle in the universe.

But in the 1950s, an experimental physicist at Columbia University named Chien-Shiung Wu devised an experiment that challengedand defiedthat law. Physics, she proved, to the astonishment of the field, did not always adhere to parity. Throughout her life, in fact, this woman demonstrated that parity was not the default; she flouted gender and racial barriers and eventually came to be known as the first lady of physics.

Wu was born in 1912 in a small fishing town north of Shanghai to parents who supported education for women. She displayed an extraordinary talent for physics as a college student in China. At the urging of Jing-Wei Gu, a female professor, she set her sights on earning a Ph.D. in the United States. In 1936, she arrived by ship in San Francisco and enrolled at the University of California, Berkeley, where she studied the nuclear fission of uranium.

She was 24 years old, in a new country where she wasnt fluent in the language and where the Chinese Exclusion Act, which prohibited Chinese workers from immigrating, was in full effect. It was preceded by the Page Act, which effectively banned the immigration of Chinese women based on the assumption that they intended to be sex workers. Wu was only able to enter the US because she was a student, but she was still ineligible for citizenship. There must have been so much tension and conflict there, says Leslie Hayes, vice president for education at the New York Historical Society. Im going to this place where I wont be welcome, but if I dont go, I wont be able to fulfill my goals and dreams.

After earning her Ph.D. in 1940, she married another Chinese-American physicist, and the couple moved to the East Coast in a long-shot search for tenure-track work. Major research institutes at the time were generally unwilling to hire women, people of color, or Jewish people, and the uptick in anti-Asian sentiment during World War II certainly didnt help. She was discriminated against as an Asian, but more so as a woman, Tsai-Chien Chiang wrote in his biography of Wu.

Nevertheless, shortly after a teaching stint at a womens college, she became the first female faculty member in Princeton Universitys physics department. That job was short lived; in 1944, Columbia University recruited her to work on the Manhattan Project, where she would advise a stumped Enrico Fermi on how to sustain a nuclear chain reaction.

Wu returned to research at Columbia after the war. Her reputation for brilliance and meticulousness grew in 1949 when she became the first to design an experiment that proved Fermis theory of beta decay, a type of radioactive decay in which a neutron spontaneously breaks down into a proton and a high-speed electron (a.k.a., a beta particle). In 1956, two theoretical physicists, Tsung-Dao Lee of Columbia and Chen Ning Yang of Princeton, sought Wus expertise in answering a provocative question: Is parity really conserved across the universe?

The law had been called into question by a problem known as theta-tau puzzle, a recently discovered paradox in particle physics. Theta and tau were two subatomic particles that were exactly the same in every respectexcept that one decayed into two smaller particles, and the other into three. This asymmetry confounded the physics community. Yang and Lee dove deep into the literature to see if anyone had ever actually proven that the nucleus of a particle always behaved symmetrically. As they found out, nobody had. So Wu, who they consulted during the process of writing their theoretical paper, got to work designing an experiment that would prove that it didnt.

Over the next few months, the men were in near constant communication with Wu. The monumental experiment that she designed and carried out rang the death knell for the concept of parity conservation in weak interactions, wrote nuclear physicist Noemie Benczer-Koller in her biography of Wu. Wus findings sparked such a sensation that they led to a Nobel Prize in physicsbut only for Yang and Lee. Wus groundbreaking work in proving the theory they advanced was ignored.

Though her genius allowed her to work in the same spaces as theoretical scientists, says Hayes, once there, she was not treated as a peer. But despite how frequently she experienced discrimination throughout her careerduring which she won every award in the field except the NobelWu didnt stop researching until her retirement in 1981.

Throughout her life, she was an outspoken advocate for the advancement of female physicistscampaigning, for the rest of her life, for the establishment of parity where it actually counted. Why didnt we encourage more women to go into science? she asked the crowd at an MIT symposium in 1964. I wonder whether the tiny atoms and nuclei, or the mathematical symbols, or the DNA molecules, have any preference for either masculine or feminine treatment.

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The Standard Model of Particle Physics May Be Broken A Physicist at the Large Hadron Collider Explains – SciTechDaily

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A recent series of precise measurements of already known, standard particles and processes have threatened to shake up physics.

As a physicist working at the Large Hadron Collider (LHC) at CERN, one of the most frequent questions I am asked is When are you going to find something? Resisting the temptation to sarcastically reply Aside from the Higgs boson, which won the Nobel Prize, and a whole slew of new composite particles? I realize that the reason the question is posed so frequently is down to how we have depicted progress in particle physics to the wider world.

We often talk about progress in terms of discovering new particles, and this is frequently true. Studying a new, very heavy particle helps us see underlying physical processes often without annoying background noise. That makes it easy to explain the value of the discovery to the general public and politicians.

Recently, however, a series of precise measurements of ordinary already known, standard particles and processes have threatened to shake up physics. And with the LHC getting ready to run at higher energy and intensity than ever before, it is time to start discussing the implications widely.

The storage-ring magnet for the Muon G-2 experiment at Fermilab. Credit: Reidar Hahn, Fermilab

In truth, particle physics has always proceeded in two ways, of which new particles is one. The other is by making very precise measurements that test the predictions of theories and look for deviations from what is expected.

The early evidence for Einsteins theory of general relativity, for example, came from discovering small deviations in the apparent positions of stars and from the motion of Mercury in its orbit.

Particles obey a counter-intuitive but hugely successful theory called quantum mechanics. This theory shows that particles far too massive to be made directly in a lab collision can still influence what other particles do (through something called quantum fluctuations.) Measurements of such effects are very complex, however, and much harder to explain to the public.

But recent results hinting at unexplained new physics beyond the standard model are of this second type. Detailed studies from the LHCb experiment found that a particle known as a beauty quark (quarks make up the protons and neutrons in the atomic nucleus) decays (falls apart) into an electron much more often than into a muon the electrons heavier, but otherwise identical, sibling. According to the standard model, this shouldnt happen hinting that new particles or even forces of nature may influence the process.

The LHCb experiment at CERN. Credit: CERN

Intriguingly, though, measurements of similar processes involving top quarks from the ATLAS experiment at the LHC show this decay does happen at equal rates for electrons and muons.

Meanwhile, the Muon g-2 experiment at Fermilab in the US has recently made very precise studies of how muons wobble as their spin (a quantum property) interacts with surrounding magnetic fields. It found a small but significant deviation from some theoretical predictions again suggesting that unknown forces or particles may be at work.

The latest surprising result is a measurement of the mass of a fundamental particle called the W boson, which carries the weak nuclear force that governs radioactive decay. After many years of data taking and analysis, the experiment, also at Fermilab, suggests it is significantly heavier than theory predicts deviating by an amount that would not happen by chance in more than a million million experiments. Again, it may be that yet undiscovered particles are adding to its mass.

Interestingly, however, this also disagrees with some lower-precision measurements from the LHC (presented in this study and this one).

While we are not absolutely certain these effects require a novel explanation, the evidence seems to be growing that some new physics is needed.

Of course, there will be almost as many new mechanisms proposed to explain these observations as there are theorists. Many will look to various forms of supersymmetry. This is the idea that there are twice as many fundamental particles in the standard model than we thought, with each particle having a super partner. These may involve additional Higgs bosons (associated with the field that gives fundamental particles their mass).

Others will go beyond this, invoking less recently fashionable ideas such as technicolor, which would imply that there are additional forces of nature (in addition to gravity, electromagnetism and the weak and strong nuclear forces), and might mean that the Higgs boson is in fact a composite object made of other particles. Only experiments will reveal the truth of the matter which is good news for experimentalists.

The experimental teams behind the new findings are all well respected and have worked on the problems for a long time. That said, it is no disrespect to them to note that these measurements are extremely difficult to make. Whats more, predictions of the standard model usually require calculations where approximations have to be made. This means different theorists can predict slightly different masses and rates of decay depending on the assumptions and level of approximation made. So, it may be that when we do more accurate calculations, some of the new findings will fit with the standard model.

Equally, it may be the researchers are using subtly different interpretations and so finding inconsistent results. Comparing two experimental results requires careful checking that the same level of approximation has been used in both cases.

These are both examples of sources of systematic uncertainty, and while all concerned do their best to quantify them, there can be unforeseen complications that under- or over-estimate them.

None of this makes the current results any less interesting or important. What the results illustrate is that there are multiple pathways to a deeper understanding of the new physics, and they all need to be explored.

With the restart of the LHC, there are still prospects of new particles being made through rarer processes or found hidden under backgrounds that we have yet to unearth.

Written by Roger Jones, Professor of Physics, Head of Department, Lancaster University.

This article was first published in The Conversation.

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Our Reality May Only Be Half of a Pair of Interacting Worlds – SciTechDaily

Posted: at 7:14 pm

New research explores the imaginative possibility that our reality is only one half of a pair of interacting worlds.

Physicists sometimes come up with bizarre stories that sound like science fiction. Yet some turn out to be true, like how the curvature of space and time described by Einstein was eventually confirmed by astronomical measurements. Others linger on as mere possibilities or mathematical curiosities.

In a new paper in Physical Review Research, Joint Quantum Institute (JQI) Fellow Victor Galitski and JQI graduate student Alireza Parhizkar investigated the imaginative possibility that our reality is only one half of a pair of interacting worlds. Their mathematical model may offer a fresh perspective for looking at fundamental aspects of realityincluding why our universe expands the way it does and how that relates to the most minuscule lengths allowed in quantum mechanics. These topics are critical to understanding our universe and are part of one of the great mysteries of modern physics.

The pair of scientists stumbled upon this new perspective when they were looking into something quite different, research on sheets of graphenesingle atomic layers of carbon in a repeating hexagonal pattern. They realized that experiments on the electrical properties of stacked sheets of graphene produced results that resembled little universes and that the underlying phenomenon might generalize to other areas of physics. In stacks of graphene, new electrical behaviors arise from interactions between the individual sheets, so maybe unique physics could similarly emerge from interacting layers elsewhereperhaps in cosmological theories about the entire universe.

A curved and stretched sheet of graphene laying over another curved sheet creates a new pattern that impacts how electricity moves through the sheets. A new model suggests that similar physics might emerge if two adjacent universes are able to interact. Credit: Alireza Parhizkar, JQI

We think this is an exciting and ambitious idea, says Galitski, who is also a Chesapeake Chair Professor of Theoretical Physics in the Department of Physics. In a sense, its almost suspicious that it works so well by naturally predicting fundamental features of our universe such as inflation and the Higgs particle as we described in a follow up preprint.

Stacked graphenes exceptional electrical properties and possible connection to our reality having a twin comes from the special physics produced by patterns called moir patterns. Moir patterns form when two repeating patternsanything from the hexagons of atoms in graphene sheets to the grids of window screensoverlap and one of the layers is twisted, offset, or stretched.

The patterns that emerge can repeat over lengths that are vast compared to the underlying patterns. In graphene stacks, the new patterns change the physics that plays out in the sheets, notably the electrons behaviors. In the special case called magic angle graphene, the moir pattern repeats over a length that is about 52 times longer than the pattern length of the individual sheets, and the energy level that governs the behaviors of the electrons drops precipitously, allowing new behaviors, including superconductivity.

Galitski and Parhizkar realized that the physics in two sheets of graphene could be reinterpreted as the physics of two two-dimensional universes where electrons occasionally hop between universes. This inspired the pair to generalize the math to apply to universes made of any number of dimensions, including our own four-dimensional one, and to explore if similar phenomenon resulting from moir patterns might pop up in other areas of physics. This started a line of inquiry that brought them face to face with one of the major problems in cosmology.

We discussed if we can observe moir physics when two real universes coalesce into one, Parhizkar says. What do you want to look for when youre asking this question? First you have to know the length scale of each universe.

A length scaleor a scale of a physical value generallydescribes what level of accuracy is relevant to whatever you are looking at. If youre approximating the size of an atom, then a ten-billionth of a meter matters, but that scale is useless if youre measuring a football field because it is on a different scale. Physics theories put fundamental limits on some of the smallest and largest scales that make sense in our equations.

The scale of the universe that concerned Galitski and Parhizkar is called the Planck length, and it defines the smallest length that is consistent with quantum physics. The Planck length is directly related to a constantcalled the cosmological constantthat is included in Einsteins field equations of general relativity. In the equations, the constant influences whether the universeoutside of gravitational influencestends to expand or contract.

This constant is fundamental to our universe. So to determine its value, scientists, in theory, just need to look at the universe, measure several details, like how fast galaxies are moving away from each other, plug everything into the equations and calculate what the constant must be.

This straightforward plan hits a problem because our universe contains both relativistic and quantum effects. The effect of quantum fluctuations across the vast vacuum of space should influence behaviors even at cosmological scales. But when scientists try to combine the relativistic understanding of the universe given to us by Einstein with theories about the quantum vacuum, they run into problems.

One of those problems is that whenever researchers attempt to use observations to approximate the cosmological constant, the value they calculate is much smaller than they would expect based on other parts of the theory. More importantly, the value jumps around dramatically depending on how much detail they include in the approximation instead of homing in on a consistent value. This lingering challenge is known as the cosmological constant problem, or sometimes the vacuum catastrophe.

This is the largestby far the largestinconsistency between measurement and what we can predict by theory, Parhizkar says. It means that something is wrong.

Since moir patterns can produce dramatic differences in scales, moir effects seemed like a natural lens to view the problem through. Galitski and Parhizkar created a mathematical model (which they call moir gravity) by taking two copies of Einsteins theory of how the universe changes over time and introducing extra terms in the math that let the two copies interact. Instead of looking at the scales of energy and length in graphene, they were looking at the cosmological constants and lengths in universes.

Galitski says that this idea arose spontaneously when they were working on a seemingly unrelated project that is funded by the John Templeton Foundation and is focused on studying hydrodynamic flows in graphene and other materials to simulate astrophysical phenomena.

Playing with their model, they showed that two interacting worlds with large cosmological constants could override the expected behavior from the individual cosmological constants. The interactions produce behaviors governed by a shared effective cosmological constant that is much smaller than the individual constants. The calculation for the effective cosmological constant circumvents the problem researchers have with the value of their approximations jumping around because over time the influences from the two universes in the model cancel each other out.

We dont claimeverthat this solves cosmological constant problem, Parhizkar says. Thats a very arrogant claim, to be honest. This is just a nice insight that if you have two universes with huge cosmological constantslike 120 orders of magnitude larger than what we observeand if you combine them, there is still a chance that you can get a very small effective cosmological constant out of them.

In preliminary follow up work, Galitski and Parhizkar have started to build upon this new perspective by diving into a more detailed model of a pair of interacting worldsthat they dub bi-worlds. Each of these worlds is a complete world on its own by our normal standards, and each is filled with matching sets of all matter and fields. Since the math allowed it, they also included fields that simultaneously lived in both worlds, which they dubbed amphibian fields.

The new model produced additional results the researchers find intriguing. As they put together the math, they found that part of the model looked like important fields that are part of reality. The more detailed model still suggests that two worlds could explain a small cosmological constant and provides details about how such a bi-world might imprint a distinct signature on the cosmic background radiationthe light that lingers from the earliest times in the universe.

This signature could possibly be seenor definitively not be seenin real world measurements. So future experiments could determine if this unique perspective inspired by graphene deserves more attention or is merely an interesting novelty in the physicists toy bin.

We havent explored all the effectsthats a hard thing to do, but the theory is falsifiable experimentally, which is a good thing, Parhizkar says. If its not falsified, then its very interesting because it solves the cosmological constant problem while describing many other important parts of physics. I personally dont have my hopes up for that I think it is actually too big to be true.

Reference: Strained bilayer graphene, emergent energy scales, and moir gravity by Alireza Parhizkar and Victor Galitski, 2 May 2022, Physical Review Research.DOI: 10.1103/PhysRevResearch.4.L022027

The research was supported by the Templeton Foundation and the Simons Foundation.

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Whiz kid from Indonesia earns master’s at University of Waterloo in physics at 17 – Waterloo Region Record

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WATERLOO Cendikiawan Suryaatmadja of Indonesia is taking a break this summer before starting his PhD.

The 17-year-old is the third-youngest person in University of Waterloos history to graduate with a masters degree in physics, and he dreams about using the fundamental building blocks of the physical world to make it better.

I still have a long way to go, said Suryaatmadja during an interview at the Dana Porter Library on campus.

His research will focus on quantum information theory using quantum physics to manage the flow of information.

I think it is a very important field of physics, said Suryaatmadja. Its new, its emerging.

UW is a leading centre of research on quantum information theory, and the next generation of supercomputers that will use that research quantum computers.

You are essentially looking at things from the most fundamental and simplest level, and you just start to build a whole structure out of it, said Suryaatmadja.

After almost six years in Canada, Suryaatmadja is still not used to the changing weather and the need for so many clothes. He misses the warm, consistent weather of his home and the flavourful food of Indonesia.

Even a simple meal can have 12 to 14 spices, oh man, said Suryaatmadja. Im not saying the food in Canada is bad, but you guys use a lot of butter.

He also misses his family, and tries to speak with them every week. But he likes the diversity of Canada, especially around the UW campus.

You meet people with different ideas, different cultures, different perspectives, said Suryaatmadja. It really helps you think more critically, it really helps you get exposed to thoughts that are different from your own. I think Canada excels at that.

He grew up in Bogor, a city south of Jakarta on the Indonesian Island of Java. His first language is Indonesian, and Suryaatmadja taught himself English.

When Suryaatmadja started elementary school he was placed in Grade 3. After Grade 4 he studied on his own, and was recruited by UW when he was 12. Four years later he had completed a bachelors degree in mathematical physics with a minor in pure mathematics. It took more than a year to complete the masters and his PhD will also be done at UW.

Jeff Casello, UWs associate vice-president of graduate studies and post-doctoral affairs, calls Suryaatmadjas academic accomplishments remarkable.

Having the academic skills and personal drive to earn a masters degree at age 17 reflects a level of accomplishment that is incredibly rare, said Casello.

Suryaatmadja laughs at how it came about. He pressed the wrong button in the elevator at the institute in Bogor where he studied and prepared for math competitions. He walked off the elevator and into the arms of two UW recruiters Jean Lowry and Ken Seng Tan.

I just talked to them actually, said Suryaatmadja. This was before I graduated from high school.

At this point, he looks forward to a life of research that breaks new ground in physics and quantum information theory.

I just want to be a researcher. I dont know where. Lets see where things go. I still have a lot of time to make plans.

During the past six years hes joined many clubs on campus, and enjoys doing improv. He likes watching TV shows and movies that are comedies, or Sci-Fi blockbusters such as Dune and Blade Runner 2049. He enjoys Manga, DC Comics and books by Neil Gaiman, Terry Pratchett and graphic novels by Grant Morrison.

And I like walking a lot, especially in this weather, said Suryaatmadja.

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Jim Al-Khalili: How our ancient sense of wonder drives physics deeper into the unknown – Big Think

Posted: at 7:13 pm

To our earliest human ancestors, the world was a bewildering place. From devastating natural disasters to the countless stars in the night sky, their universe was filled with phenomena that defied explanation.

As humans whose minds worked in just the same way as ours, they must have spent endless hours pondering their place within this mystifying world. They would have asked many of the same questions we continue to struggle with today: Who am I? What is my place in the universe? What is the nature of my sense of self?

To answer these questions, our ancestors filled their world with magic, monsters, and supernatural beings. They told stories about mythical creations that sparked a sense of wonder and mystery about the nature of the universe. Yet not so long ago on the timescale of human history, that all began to change.

Starting with the philosophers of the ancient world, humans began to question whether the natural forces that once seemed so far beyond our comprehension could be explained after all. Over the centuries, this movement grew into countless fields of scientific research.

As we began to uncover the fundamental building blocks of our universe, the need for magical forces to explain what we couldnt comprehend began to subside. Today, for example, the fields of quantum mechanics and general relativity tell us much about the nature of the matter that surrounds us, from subatomic to cosmological scales.

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Yet at the same time, ideas about the magical forces which instilled such wonder in our ancient ancestors still run deep in human culture. This natural sense of awe seems to have led to some unfortunate misconceptions about the brilliant minds who have contributed so much to our understanding of the universe.

Theres a notion that scientists have this sterile, clinical view of the world, that leaves no room for mystery, awe, or magic, Jim Al-Khalili, a theoretical physicist and author of The World According to Physics, told Big Think.

From stereotypes in fiction that frame scientists as brashly dismissive of any idea that seems slightly illogical, to groups who view science as an attack on their faith, these ideas remain popular today. But to Al-Khalili, they couldnt be further from the truth.

On the contrary, everything I learn about how the world is tells me its full of wonder, he told Big Think. The idea that Newton discovered that the invisible force pulling the apple down to the ground is exactly the same force keeping the Moon in orbit around the Earth is utterly profound and awe-inspiring.

To illustrate the wonder that pervades scientific research, Al-Khalili imagines the sum of human knowledge as an island.

The interior of the island is the well-established science we know very well; its shoreline is the limits of our understanding; and beyond it is the ocean of the unknown.

The shorelines of our island are constantly expanding outward. But just like the earliest seafarers, there is no way for us to know just how far the ocean surrounding extends, or if it even ends. For physicists like Al-Khalili, the ocean of the unknown is particularly vast.

So far, our knowledge of quantum mechanics has culminated in the Standard Model, which aims to describe the nature of the fundamental particles and forces that comprise our universe. The Standard Model can reliably explain the results of almost all experiments that physicists have thrown at it. But we know that these explanations are far from complete.

Among the Standard Models most glaring gaps is that it cant explain the nature of dark matter: the mysterious substance which astronomers claim must account for roughly 85% of all mass in the universe, but whose true nature continues to elude us, despite decades of efforts to detect it.

The Standard Model also cant explain dark energy, which is the cosmic-scale force thats thought to be driving the universes continuing expansion. Even further, physicists have yet to develop a single unifying theory that can simultaneously encompass the founding principles of quantum mechanics and general relativity.

As physicists delve deeper into these questions, theyre steadily realizing the extent of the discoveries theyve yet to make; the ocean surrounding our island of knowledge only appears to grow ever more vast.

As we expand the shorelines of our island, Al-Khalili thinks that the knowledge we have gained so far could turn out to be completely wrong, leading to completely new conceptions about the most basic building blocks of our universe.

One-hundred years from now, I may look back at the Jim of the early 21st century and think I was just as nave as the medieval scholars who thought the Sun orbited the Earth.

Yet physicists arent the only ones who perceive this expanding ocean. Ultimately, the fundamental phenomena they aim to explain can only go so far toward answering the questions first pondered by our distant ancestors about who we really are, and where we fit within the universe.

Despite millennia of scrutiny by billions of minds, our ocean of the unknown is only growing: a picture that is being repeated time and again across many fields of scientific research. In solving these mysteries, researchers from across the broad scope of modern science are increasingly realizing just how intertwined their fields really are.

Just as Newton first discovered the astonishing link between a falling apple and the orbiting Moon, extending our island further may involve finding links between phenomena we have previously thought of as unconnected. All the same, there is no guarantee that we will ever know how far the ocean surrounding us extends.

For Al-Khalili, if we look back at how far our scientific knowledge has come, and just how far we have yet to go, its impossible to claim that science is purely a cold, rational exercise.

We dont know if we will ever one day know everything about the nature of reality, and in a way, thats nice. Its frustrating but beautiful that we may never have all the answers.

Far from eliminating the sense of awe and wonder first felt by our distant ancestors, expanding our knowledge of science can only help it to grow. As Douglas Adams once put it, Id take the awe of understanding over the awe of ignorance any day.

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