Daily Archives: April 6, 2022

2022 APR 05 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- New research on Biotechnology - Biologics is the subject of a report. According to news reporting originating from Creteil, France, by NewsRx correspondents, research stated, Treatment options for psoriasis (PsO) and psoriatic arthritis (PsA) have evolved significantly throughout the era of biologics. Clinical trials are inadequate to assess the relative long-term efficacy of biologics and are often insufficient regarding safety.

Our news editors obtained a quote from the research from University Paris Est Creteil, To assess the long-term persistence of different biologic classes to treat PsO and PsA. This nationwide cohort study involved the administrative health care database of the French health insurance scheme linked to the hospital discharge database. All adults with PsO and PsA who were new users of biologics (not in the year before the index date) from January 1, 2015, to May 31, 2019, were included and followed up through December 31, 2019. Patients hospitalized for PsA in the PsO cohort and for PsO in the PsA cohort in the year before the index date were excluded. Data were analyzed from June 1 to October 31, 2021. Persistence was defined as the time from biologic therapy initiation to discontinuation and was estimated using the Kaplan-Meier method. Comparison of persistence by biologic class involved using propensity score-weighted Cox proportional hazards regression models and adjustment on specific systemic nonbiologics (time-dependent variables). A total of 16 892 patients with PsO were included in the analysis (mean [SD] age, 48.5 [13.8] years; 9152 men [54.2%] men). Of these, 10 199 patients (60.4%) started therapy with a tumor necrosis factor (TNF) inhibitor; 3982 (23.6%), with an interleukin 12 and interleukin 23 (IL-12/23) inhibitor; and 2711 (16.0%), with an interleukin 17 (IL-17) inhibitor. An additional 6531 patients with PsA (mean [SD] age, 49.1 [12.8] years; 3565 [54.6%] women) were included; of these, 4974 (76.2%) started therapy with a TNF inhibitor; 803 (12.3%), with an IL-12/23 inhibitor; and 754 (11.5%), with an IL-17 inhibitor. Overall 3-year persistence rates were 40.9% and 36.2% for PsO and PsA, respectively. After inverse probability of treatment weighting and adjustment, the IL-17 inhibitor was associated with higher persistence compared with the TNF inhibitor for PsO (weighted hazard ratio [HR], 0.78 [95% CI, 0.73-0.83]) and PsA (weighted HR, 0.70 [95% CI, 0.58-0.85]) and compared with the IL-12/23 inhibitor for PsA (weighted HR, 0.69 [95% CI, 0.55-0.87]). No difference between the IL-17 inhibitor and IL-12/23 inhibitor for PsO was noted. The IL-12/23 inhibitor was associated with higher persistence than the TNF inhibitor for PsO (weighted HR, 0.76 [95% CI, 0.72-0.80]), with no difference observed for PsA. The findings of this cohort study suggest that IL-17 inhibitors are associated with higher treatment persistence than the TNF inhibitor for PsO and PsA. Interleukin 17 inhibitors were also associated with higher persistence than the IL-12/23 inhibitor for PsA, with no difference for PsO.

According to the news editors, the research concluded: However, the persistence rates of all biologics remained globally low at 3 years.

This research has been peer-reviewed.

For more information on this research see: Long-term Persistence of First-line Biologics for Patients With Psoriasis and Psoriatic Arthritis in the French Health Insurance Database. JAMA Dermatology, 2022. JAMA Dermatology can be contacted at: Amer Medical Assoc, 330 N Wabash Ave, Ste 39300, Chicago, IL 60611-5885, USA.

The news editors report that additional information may be obtained by contacting Laetitia Penso, EpiDermE, University Paris Est Creteil, Creteil, France. Additional authors for this research include Laura Pina Vegas, Pascal Claudepierre and Emilie Sbidian.

Publisher contact information for the journal JAMA Dermatology is: Amer Medical Assoc, 330 N Wabash Ave, Ste 39300, Chicago, IL 60611-5885, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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University Paris Est Creteil Reports Findings In Biologics (Long-term Persistence Of First-line Biologics For Patients With Psoriasis And Psoriatic...

Sustained adoption of conventional disease modifying anti-rheumatic drugs (DMARDs), especially in cost sensitive regions, is projected to push the demand forpsoriatic arthritis treatmentin coming years.

Nearly 70% of the psoriasis patient population is prone to psoriatic arthritis, and up to 20% of arthritis patients are susceptible to acquire psoriasis, according to the recent findings of the Arthritis Foundation.

The rate of increasing burden of psoriasis and psoriatic arthritis on healthcare industry has been boosting clinical research in the field of psoriatic arthritis, in recent years.

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Role of Strong Product Pipeline & Mounting Clinical Research Investments

Over 20 drugs for psoriasis and psoriatic arthritis are currently in the phase II of pipeline, whereas more than 28 are in phase III of clinical trial, as indicated by the National Psoriasis Foundation. However, around 24 drugs have already received FDA approval for inclusion in the treatment for psoriasis and psoriatic arthritis.

While such a strong product pipeline continues to drive the demand for psoriasis and psoriatic arthritis treatment, a new research points to the shifting focus of several drug manufacturers to competitive pricing strategies, in an effort to attain widespread acceptance in coming years. Recently, Future Market Insights released a new intelligence based on the analysis of global psoriatic arthritis treatment market. The study forecasts a robust over-7% yearly growth for the market in 2022.

Industry Behemoths Cover More than 55% Market Value Share

In a fairly consolidated global landscape of psoriatic arthritis treatment market, more than 55% share of the total revenue is accounted by industry giants such as Novartis AG and AbbVie Inc. that include biologics in their core portfolio. While market leaders are maintaining focus on FDA approvals and clinical trials, research also points to the increasing importance of diverse pricing strategies.

Moreover, prominent players in psoriatic arthritis treatment market are likely to augment investments in R&D of biosimilars, biologics, and TNF (tumor necrosis factor) inhibitors to target regional markets. A number of leading drug manufacturers are also maintaining sizable investments in DMARDs that are scheduled for market entry in next few years. This is perceived as a strong factor improving growth prospects of psoriatic arthritis treatment market, according to the report.

Besides all these, strategic acquisitions, partnerships, and collaborations will remain the preferred expansion strategies adopted by a majority of prominent operators in psoriatic arthritis treatment landscape, says a senior research analyst at the company.

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Demand for Biologics & DMARDs Gaining Momentum

Research-driven understanding of the pathophysiology of psoriatic arthritis is fueling the introduction of innovative therapies in psoriatic arthritis treatment market, triggering innovations among the market participants thereby supporting the growth of psoriatic arthritis treatment market. Targeted biological therapy has been demonstrating a decent success rate in terms of inducing temporary pain relief resultant of psoriatic arthritis, and thus continues to represent an attractive position in the psoriatic arthritis treatment market.

The report says that the demand for biologics accounts for more than 55% share of the global market revenue, whereas DMARDs demand makes up for more than 3/4thof the total market value. Although a majority of psoriatic arthritis patients opt for injectable as a preferred route of administration of psoriatic arthritis treatment, increasing introduction of innovative oral drugs is uplifting the popularity of orally administered psoriatic arthritis treatment.

Development of novel oral treatments for psoriatic arthritis is likely to favor the growth of North Americas market. Growing availability of combination therapies and relatively economical biosimilar antibody therapeutics are identified to be the primary boosters for the growth of Europes market. Collectively, North America and Europe account for over 60% share in the global value of psoriatic arthritis treatment market. The report indicates that the psoriatic arthritis market in Asia Pacific is likely to display high growth potential in the course of next few years.

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Psoriatic Arthritis (Psa) Treatment Market Growing at a Healthy 7.1% CAGR, and Projected a Valuation - PharmiWeb.com

Hair loss can be hard. For many people, losing something that is a such a big part of their identity can make them feel uncomfortable in their own skin. Some thinning hair is inevitable with aging, but luckily, it can also be caused by many other factors that are more under your control like hormonal imbalances, stress, or even what type of hair brush you use. With so many possible culprits, though, it may seem impossible to get to the root of the problem. But if you're struggling with hair loss in your sixth decade and beyond, it is likely that a common condition is to blame. Read on to discover what could be making you lose your hair if you're over 50, and how to turn things around.

RELATED: If You're Over 65, Not Doing This in the Shower Is Causing Hair Loss.

One of the most common culprits of hair loss after age 50 is inflammation, a natural response in the body that helps protect from infection and diseases. But if you are chronically inflamed, serious health issues can occur. According to Ben Behnam, MD, FASD, and medical director at hair loss treatment brand Happy Head, inflammation can damage the hair follicles, which can cause strands to fall out. Inflammation can also damage the hair shaft, making it difficult for new hair to grow.

Examples of inflammation on the scalp include dandruff, psoriasis, alopecia areata, and redness and flakiness. Each of these conditions varies, but some of the most common symptoms are itchiness, burning, and even hair loss. However, Behnam notes that not all patients will experience these symptoms.

One of the many causes of inflammation in the bodywhich can ultimately lead to hair lossis an autoimmune reaction. An autoimmune reaction is when the body's immune system mistakenly attacks healthy tissue. "This can happen in a number of autoimmune diseases like lupus erythematosus or alopecia areata, both of which can cause patchy hair loss," says Cheryl Rosen, MD, board-certified dermatologist and director of dermatology at BowTiedLife.

Note that these conditions are somewhat rare: Only about 1.5 million Americans have lupus, per the Lupus Foundation of America. And alopecia areata affects about 2.1 percent of Americans, according to the National Alopecia Areata Foundation. Rosen says autoimmune reactions can also be triggered by things like infections, stress, or certain medications.

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According to the American Academy of Dermatology Association, psoriasis is an inflammatory skin condition in which your immune system turns over skin cells too quickly, causing scaly patches. A common area for these patches to develop is the scalp. The National Psoriasis Foundation says that about 8 million Americans suffer from this condition.

Dandruff, on the other hand, is a condition that causes the skin on the scalp to flake. According to Mayo Clinic, it can be triggered by dry skin, a yeast-like fungus, or sensitivity to hair products. Per The International Journal of Trichology, the condition impacts around 50 percent of adults.

Hair loss can occur with both psoriasis and dandruff due to intense itching that manually pulls out the hair. The inflammation of the follicle that causes the conditions can also slow or stop hair growth.ae0fcc31ae342fd3a1346ebb1f342fcb

Fortunately, there are treatments available to improve the condition of the scalp and promote new hair growth. Rosen says they include anti-inflammatory medications, topical treatments, and light therapy.

For example, if you have psoriasis, you may be prescribed a topical steroid to reduce your symptoms, says Behnam. If you have dandruff, you may be offered an anti-dandruff shampoo, such as Nizoral, to soothe the inflammation. For cases of alopecia areata, there are injectable drugs available to reduce inflammation. Over time, hair growth can be restored. "If you are suffering from hair loss due to inflammation, talk to your doctor about the best treatment option for you," says Rosen. That way, you can restore your strands to their healthiest state.

RELATED: If Your Hair Is Thinning, This Food Could Be to Blame, Study Says.

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If You're Over 50, Inflammation Is Making You Lose Your Hair Best Life - Best Life

The immune system is the body's first line of defensewhen infection-causing pathogens invade, the immune system springs into action, launching substances designed to neutralize the invaders. But that process can go haywire, and the immune system can actually attack the body's own tissues and organs. That's what's known as autoimmune disease. There are several of them, and their symptoms can be wide-ranging, from uncomfortable to potentially debilitating. These are the most common signs your body is attacking itself, according to doctors. Read on to find out moreand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Could be: Rheumatoid arthritis

When the immune system attacks the linings of the joints, rheumatoid arthritis can develop, causing painful swelling. Smaller joints tend to be affected first, followed by larger ones; about 40 percent of people affected by rheumatoid arthritis experience symptoms that don't involve the joints, such as issues with the eyes or skin. "In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels," says the Mayo Clinic.

Could be: Lupus, Arthritis

"The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling," says the U.S. National Library of Medicine. Inflammation is a hallmark of a number of autoimmune conditions, the most common being lupus, a complex disease most often diagnosed in women between the ages of 15 and 44. It has a wide range of symptoms, including fatigue, fever, joint pain, stiffness and swelling, and a facial rash.

Could be: Multiple sclerosis

Multiple sclerosis is an autoimmune disorder that causes the body's immune system to mistakenly attack its own healthy cells, damaging the sheath that covers the nerves. This can lead to various neurological symptoms. Numbness and tingling is one of the most common first signs, doctors say, as are vision problems (which tend to affect only one eye). Other symptoms include balance problems, trouble walking, stiffness or weakness in the limbs, and fatigue.

RELATED: I Have Omicron and This is What it Feels Like

Could be: Crohn's disease

Crohn's disease is a type of inflammatory bowel disease (IBS) in which the immune system attacks the digestive tract, causing chronic inflammation. That can lead to abdominal pain, diarrhea, blood in the stool, fatigue, weight loss, and even malnutrition. Symptoms can range from mild to severe and might involve any part of the small or large intestine. It's treated with anti-inflammatory drugs, immunosuppressants and antibiotics.

RELATED: 6 Signs You Might Have Multiple Sclerosis

Could be: Psoriasis, Lupus6254a4d1642c605c54bf1cab17d50f1e

Skin-related symptoms are another common sign of autoimmune disorders. A red "butterfly rash" that develops over the nose and both cheeks is a common sign in lupus. In psoriasis, the body's skin cells go into overproduction mode and build up on the skin in rough, red patches or silvery scales. In psoriatic arthritis, joint pain, redness and swelling accompany the scaling. Both conditions are treatable with medication.

RELATED: COVID Symptoms Usually Appear Like This

Could be: Type 1 diabetes

Type 1 diabetes develops when the immune system destroys cells in the pancreas that are responsible for generating insulin, the hormone that helps the body process sugar and turn it into energy. Without that processor, blood sugar can rise to dangerous levels, damaging blood vessels and increasing the risk of heart disease, stroke, dementia, and blindness. Although it's most commonly diagnosed in childhood, type 1 diabetes can develop at any age. Other symptoms include frequent thirst, increased urination, fatigue, constant hunger, and intentional weight loss.

And to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch COVID.

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Signs Your Body Is Attacking Itself, Say Doctors Eat This Not That - Eat This, Not That

Awards season is in full swing, and now that weve all had some time to digest the Will SmithChris Rock slap at the Oscars last Sunday, its time to turn our collective attention to the Grammys. Below, find all the details you need on how to watch the 2022 Grammy Awards, on TV, livesteam, or online:

The 64th Grammy Awards will be held on Sunday, April 3, at 8 p.m. E.T.

For the first time, this years Grammys will be held in Las Vegas, so expect plenty of ads for casinos and strip jokes from presenters.

The Grammys will be televised live on CBS, and if you have cable, thats probably your easiest route toward taking in all the award-winning performances.

Cable subscribers can stream the Grammys live on cbs.com and the CBS app by logging in with their provider, but if youre a cord-cutter, dont worry, all is not lost: You can access the ceremony through Paramount+, the official streamer of the Grammys, or through subscriptions to Hulu Live TV, YouTubeTV, AT&T TV, and FuboTV. (Pro tip: Take advantage of the free trial that many of these platforms offer!)

Grammys 2022 Red Carpet: See All The Celebrity Dresses, Outfits, And Looks Here

Photo: Getty Images

Jared Leto in Gucci

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How to Watch the 2022 Grammy Awardson TV or Online - Verve Times