Daily Archives: April 6, 2022

UAH Space Hardware Club team will connect area students with International Space Station – UAH News

Posted: April 6, 2022 at 9:00 pm

The ARISS team, from left: Front Megan Jordan and Rebekah Clark. Back Ocean Bowling, David Tutinzhu, Aiden Price, Joseph Hayes, Tony Lope and Jaiden Stark.

Space Hardware Club

Eight area sixth and eighth graders will be placing a long-distance call to lower Earth orbit when they dial up the International Space Station (ISS) via ham radio on April 7.

The students from New Hope Elementary, Sparkman Middle and Mountain Gap Middle schools will get a rare live interview with the ISS astronauts from the SHC Communications Lab in the UAH Engineering Building, courtesy of a Space Hardware Club (SHC) team at The University of Alabama in Huntsville (UAH) and the Amateur Radio on the International Space Station (ARISS) program.

The SHC team took on the project after a proposal was submitted to ARISS by Amber Porteous, a junior in aerospace engineering at UAH, a part of the University of Alabama System. Advised by Dr. Richard Tantaris, a mechanical and aerospace engineering lecturer, and Dr. Gang Wang, an associate professor of mechanical and aerospace engineering, SHC has been involved with ARISS before, most recently in 2017.

We luckily got the contact, says Porteous, a Mobile native. In May of 2021, we heard from the ARISS organization that we were one of nine organizations that had been accepted for a contact in the spring of 2022.

ARISS worked to schedule the contact while SHC worked on organizing the ham radio station.

Porteous served as the SHCs outreach manager last year and says she developed a passion for Science, Technology, Engineering and Math (STEM) education.

Rebekah Clark, a junior aerospace engineering major from Tampa, Fla., who is the current SHC outreach manager, says her passion for outreach began when she was a Girl Scout for 13 years in grade school and hosted team and individual service projects to win awards for community service. They often involved educating younger Girl Scouts or students younger than herself.

After finishing my time in Girl Scouts, I came to UAH and began to miss being involved in service projects and I missed the opportunity to be in front of students, she says. Soon I heard of the vacancy for the SHC outreach program manager position, as well as Amber's successful application to the ARISS program, and I immediately wanted to jump in headfirst as this is a major program that Amber and I could not have completed without each other."

ARISS David Jordan is the teams technical advisor.

Hes been able to walk Amber and I through the logistical process and paperwork needed to be approved for ISS contact, Clark says. Kathy Lamont serves as our ARISS educational advisor and has been able to help us organize our educational day presentations for each middle and elementary school.

She says ARISS contact veterans, UAH alumni and former SHC members Beth Dutour and Mark Becnel helped the team, as well.

Through its outreach programs, the ARISS effort has affected many more than the eight students invited to participate in the ISS contact, Clark says.

During our educational visits to the schools, the UAH SHC ARISS team was able to teach approximately 800 students about STEM topics such as rocketry, high altitude ballooning, ham radio and the history of the ISS, she says. In addition to this, the ARISS contact event will be publicly streamed and we hope to reach even more students beyond Huntsville and Madison County.

The students who will speak to the astronauts were selected by the SHC ARISS team after a blind question submission process.

One of the biggest rules we gave the students when submitting questions was, If you can Google it, it's too easy a question, Clark says.

Once the team narrowed the submissions to around six or eight questions, a poll was created for SHC members to vote on which questions they liked the best, she says.

Only after this double vote would we return to find the names of the students and reach out to the school to let them know who was selected.

ARISS SHC members are:

We have had some really great support for our ARISS project, Clark says. We have had a lot of Space Hardware Club members volunteer for our educational days.

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Filmus visited the CLTC-CONAE-NEUQUEN deep space station, which is a bridge of cooperation with China and the world – Amico Hoops

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The province of Neuquen welcomed the visit of the Minister of Science, Technology and Innovation, Daniel Filmus, who toured the CLTC-CONAE-NEUQUEN deep space station accompanied by a delegation led by CONAE Executive and Technical Director, Ral Kolichevsky, along with officials of the Argentine Space Agency. The minister toured the interpretation room, where the content of Chinas space activities and missions of CONAEs national space plan, the stations operations room and the antenna, of great sensitivity necessary for interplanetary exploration, were revealed. It should be noted that Argentina provides support for the station, whose facilities provide time for the use of the antenna for the National Astronomical Society for Research in Outer Space.

During his visit to the CLTC-CONAE-NEUQUEN station, Vilmus noted: We are touring the facilities with the idea of deepening cooperation in space and satellite research with both China and the European Union. The deep space radio astronomy research projects obtained through this observatory are shared. With the international scientific community. This is not just a bilateral issue. These are some of the priorities we are highlighting in the 2030 Agenda. In addition to the CLTC-CONAE-NEUQUEN station signed with the Peoples Republic of China, there is an ESA Deep Space 3 (DSA3) in Malarge City, Mendoza Province, signed with the European Space Agency (ESA).

For his part, Kolyshevsky emphasized: We reviewed with the Minister the various research projects implemented by Argentina, taking advantage of the privilege of having two deep space stations in our country, such as ESA and CLTC-CONAE-NEUQUEN. At the same time, we are exploring possibilities to continue encouraging research projects in The astronomical scientific community of our country. Coordination Director Leandro Groetzner; Director of Technology Liaison, Marcelo Collazo and Head of the International Cooperation Area in Outer Space, Stanislav Makarczuk.

The CLTC-CONAE-NEUQUEN Deep Space Station is located near the town of Bajada del Agrio in the province of Neuqun and was created from the signing of inter-institutional agreements between Chinas Satellite Launch and Tracking Control (CLTC) and the National Space Committee. Activities (CONAE), Neuqun Province and the governments of Argentina and the Peoples Republic of China.

The station has a modern antenna with a diameter of 35 meters, intended for missions of deep space exploration, and is located at distances of more than 300,000 km from Earth. Operating since April 2018, it is one of the three antennas that make up Chinas network of deep space stations, along with two others in its territory.

Station useDeep space stations are used to transmit and receive telemetry signals and to receive scientific data obtained by space missions on the Moon and the Solar System. Due to its technical characteristics of large sensitivity and its diameter of 35 meters, the antenna can be used as a radio telescope, as it allows to capture the energy needed to observe objects with weaker signals, which is a prerequisite for exploration beyond our solar system.

CLTC-CONAE-NEUQUEN provided support for the missions of the Chinese lunar exploration program ChangE-3, on the near side of the moon, and ChangE-4, on the far side of the moon, to which the ChangE-5 mission, which brought Samples from the Moon to Earth. Likewise, the station provides support for the Tianwen-1 mission of the Chinese Solar System Exploration Program. This Chinese mission to Mars will also be useful to Argentine researchers specializing in planetary geology, magnetosphere and astrobiology, among other aspects.

Argentina benefitsIn return, the agreement signed with China includes benefits for Argentina, which owns 10% of the antennas operating time to conduct national scientific research and regional and international cooperation activities.

As part of these projects, CONAE, together with researchers from the Argentine Institute of Radio Astronomy (IAR) of CONICET-CICPBA-UNLP, is carrying out radio astronomical observations and a project to design and build an instrument for astronomical use, which will be installed in astronomical radio stations. Neuqun and DS3 from Malarge in Mendoza.

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Filmus visited the CLTC-CONAE-NEUQUEN deep space station, which is a bridge of cooperation with China and the world - Amico Hoops

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Mount Everest from the SPACE! NASA shares Never-Seen-Before picture – HT Tech

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NASA has shared a stunning image of Mount Everest. The huge mountain ranges appear like shallow ravines in the image taken by astronauts aboard the International Space Station (ISS). Check the amazing picture now.

NASA: On Tuesday, NASA shared a stunning image of Mount Everest on its official Instagram handle. The image was taken by the astronomers in the International Space Station (ISS) and showcases a dream-like view of the gigantic mountain range from space. The aerial image reduces the highest mountain on the planet to mere pebble sized. While we may all have seen Mount Everest as this giant structure which stands taller than any other mountain in the world at the heart of Nepal. But watching the same structure from this perspective is extremely intriguing.

Sharing it on Instagram, NASA said, Mt. Everest like you've never seen it before. The highest mountain on Earth takes on a different perspective from the vantage point of space. An astronaut aboard the International Space Station took this near-nadir (almost straight down) photograph of Mount Everest, which towers approximately 29,029 feet (8,848 meters) above sea-level.

Highlighting the gigantic size of the mountain, NASA added in the caption, This world-renowned summit just keeps growing approximately 1 centimetre per year due to the progressive uplift of the crust caused by the convergence of the Indian and Eurasian tectonic plates. At the time of writing this, the post had garnered more than 4.31 Lakh likes and over 1200 comments.

NASA has been using its social media presence to spread more awareness about the universe we live in. Every time NASA posts an image on Instagram, it adds an informative caption along with the image to help the followers learn a little more about not only space but also the world we live in. Taking unique images of the Earth is not something NASA or the ISS is doing for the first time. A few years ago, Thomas Pesquet shared an image of Egyptian Pyramids at Giza from the ISS.

Last week, NASA conducted a joint mission with SpaceX to send four astronauts to the ISS. This was the fourth crewed-rotation mission of NASA done in partnership with private companies to enable cost-effective human transportation to and from the ISS.

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NASA Liquid Lens Space Telescope Could be 100 Times the Size of Webb – PetaPixel

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NASAs huge new James Webb Space Telescope is the most powerful telescope ever launched into space, but the agency is already looking toward the future. It is currently exploring the possibility of creating liquid lenses to make a gigantic telescope perhaps 100 times the size of the Webb.

When it comes to telescopes, bigger is better, the agency writes. Larger telescopes collect more light and allow astronomers to peer farther into space and see distant objects in greater detail.

What if there was a way to make a telescope 10 times or even 100 times bigger than before? What started as a theoretical question is now a series of experiments to see if fluids can be used to create lenses in microgravity.

The experiments are currently being stored on the ISS U.S. National Labin the United States Orbital Segment (USOS) of the International Space Station (ISS) as they await the arrival of the astronauts aboard Axiom Mission 1, a private crew mission that is scheduled to send four people to the ISS for an eight-day stay.

Private Israeli astronaut Eytan Stibbe, Mission Specialist 2 on the crew, will be carrying out the experiments as part of his research portfolio.

While liquids may be less useful as optical lenses in Earths gravity, they are great at focusing light in microgravity.

All liquids have an elastic-like force that holds them together at their surface, NASA says. This force is called surface tension. Its what allows some insects to glide across water without sinking and gives water droplets their shape. On Earth, when droplets of water are small enough (2 mm or smaller), surface tension overcomes gravity and they remain perfectly spherical. If a droplet grows much larger, it gets squished under its own weight.

But in space, blobs of water and other liquids (after wobbling about) eventually assume a perfect spherical shape.

Stibbes experiments will explore whether it will be possible for high-precision lenses and mirrors to be made in space using liquids.

We thought, why not take advantage of the way liquids naturally behave in microgravity and apply it to the construction of large-scale telescopes or space-manufactured optical components that can have all kinds of uses, says Edward Balaban, principal investigator of the Fluidic Telescope Experiment (FLUTE) at NASAs Ames Research Center. In microgravity, liquids take on shapes that are useful for making lenses and mirrors, so if we make them in space, they could be used to build telescopes that are dramatically bigger than was previously thought possible.

Researchers previously tested the idea of liquid lenses on Earth by simulating a weightless environment with water.

By injecting a liquid that can be solidified, into circular frames submerged in water, we were able to create lenses literally in a janitors bucket, Dr. Valeri Frumkin of Technion Israel Institute of Technology tells NASA. Polymers, which are also used in nail salons to make acrylic nails or in adhesives like superglue, are a natural choice for lens material.

The trick is to make sure that the water has the exact same density as the polymer were injecting so that the forces of buoyancy precisely oppose gravitational forces to simulate the conditions of weightlessness.

The solid lenses created with liquid in this way were found to have outstanding surface quality that rivals or even beats what can be created with the best polishing methods that exist in optical lens manufacturing. Whats more, they only required a fraction of the time to create compared to traditional lenses.

This method allows us to completely skip any mechanical processes such as grinding or polishing, says Technion mechanical engineering professor Moran Bercovici. The natural physics of fluids simply does all the work for us.

After successful experiments on the ground, the researchers also tested their experiment in simulated microgravity on ZeroG parabolic airplane flights. They successfully but momentarily created liquid lenses of desired shapes before the airplane stopped diving and gravity ruined the lenses.

When the experiment is done in permanent microgravity aboard the International Space Station, Stibbe will be adding an additional step to cure the fluid into a lens that holds its shape. Once the lenses are created with liquid polymers and hardened with either UV light or temperature, they will be sent back to Earth for analysis by NASA researchers at Ames.

We expect this approach will create perfectly shaped and smooth surfaces: the best surfaces to turn into mirrors, says FLUTE scientist Vivek Dwivedi at NASAs Goddard Space Flight Center.

If our station experiment is successful, it will be the first time an optical component is made in space, says Balaban. It feels a bit like making history.

If all goes well, liquid transported on multiple missions to space could be combined to create colossal space telescopes that could otherwise be too large to launch from Earth.

The James Webb Space Telescope is set to capture the highest-quality images of space humans have ever seen, but it may one day be supplanted by liquid lens telescopes 100 times as large that capture space photos we can only dream of today.

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Science News Roundup: First private astronaut mission to space station readies for launch; Gigantic Jupiter-like alien planet observed still ‘in the…

Posted: at 9:00 pm

Following is a summary of current science news briefs.

Gilead's remdesivir fails to show benefit in European trial; no fetus risk seen with first trimester vaccination

The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review. Two promising drugs for COVID-19 fail to deliver

Gigantic Jupiter-like alien planet observed still 'in the womb'

Scientists have observed an enormous planet about nine times the mass of Jupiter at a remarkably early stage of formation - describing it as still in the womb - in a discovery that challenges the current understanding of planetary formation. The researchers used the Subaru Telescope located near the summit of an inactive Hawaiian volcano and the orbiting Hubble Space Telescope to detect and study the planet, a gas giant orbiting unusually far from its young host star. Gas giants are planets, like our solar system's largest ones Jupiter and Saturn, composed mostly of hydrogen and helium, with swirling gases surrounding a smaller solid core.

First private astronaut mission to space station readies for launch

The International Space Station (ISS) is set to become busier than usual this week when its crew welcomes aboard four new colleagues from Houston-based startup Axiom Space, the first all-private astronaut team ever flown to the orbiting outpost. The launch is being hailed by the company, NASA and other industry players as a turning point in the latest expansion of commercial space ventures collectively referred to by insiders as the low-Earth orbit economy, or "LEO economy" for short.

(With inputs from agencies.)

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Science News Roundup: First private astronaut mission to space station readies for launch; Gigantic Jupiter-like alien planet observed still 'in the...

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Science News Roundup: Rare vaccine-related blood clots tied to gene; First private astronaut mission to space station readies for launch and more -…

Posted: at 9:00 pm

Following is a summary of current science news briefs.

Rare vaccine-related blood clots tied to gene; concentrated antibodies may help the immunosuppressed

The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review. Vaccine-related blood clots tied to gene, antibody variants

Scientists discover ancient cemetery of flying reptiles in Chile's Atacama desert

Scientists in Chile say they have unearthed a rare cemetery with well-preserved bones of ancient flying reptiles that roamed the Andean country's Atacama desert more than 100 million years ago. The remains belong to pterosaurs, scientists determined, flying creatures that lived alongside dinosaurs that had a long wingspan and fed by filtering water through long thin teeth, similar to flamingos.

First private astronaut mission to space station readies for launch

The International Space Station (ISS) is set to become busier than usual this week when its crew welcomes aboard four new colleagues from Houston-based startup Axiom Space, the first all-private astronaut team ever flown to the orbiting outpost. The launch is being hailed by the company, NASA and other industry players as a turning point in the latest expansion of commercial space ventures collectively referred to by insiders as the low-Earth orbit economy, or "LEO economy" for short.

(With inputs from agencies.)

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Examining the Impact of Psoriasis Disease Burden on QOL, Mental Health – AJMC.com Managed Markets Network

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Two abstracts presented at the 2022 American Academy of Dermatology (AAD) Annual Meeting explored the health-related quality of life (QOL) and mental health impact of psoriasis disease burden by severity and affected body region.

The health-related quality of life (HRQOL) impact of psoriasis was shown to be associated with severity of disease and location of lesion manifestations, according to findings of 2 abstracts presented at the 2022 American Academy of Dermatology (AAD) Annual Meeting.

As the prevalence, incidence, and morbidity of psoriasis has risen over the last 3 decades, prior research investigated the growing discussion regarding mental health and QOL in patients.

Patients with psoriasis have been shown to be at a heightened risk of depression and adverse behavioral health symptoms, in which comorbidities such as psoriatic arthritis and disease severity have been shown to exacerbate risk. The incidence of psoriasis in special areas (face, scalp, palms/soles, nails, genitals) was noted by researchers to also potentially increase disease burden.

Leveraging the multinational UPLIFT survey, a web-based survey of adults with self-reported health care providerdiagnosed psoriasis that was conducted from March 2 to June 3, 2020, they evaluated the impact of special area involvement on QOL outcomes and depression screening.1

A total of 3614 patients with psoriasis who did and did not have special area involvement were compared via Dermatology Life Quality Index (DLQI) total score and Patient Health Questionnaire-2 (PHQ-2) depression screen measurements.

Of the study cohort, 76.8% (n = 2776) had psoriasis in att least 1 special area (face, 28.1%; scalp, 53.4%; palms/soles, 24.6%; nails, 16.7%; genitals, 12.2%).

Compared with patients without special area involvement, the mean (SD) DLQI scores were shown to be higher in patients who had psoriasis in 1 or more special areas overall (9.9 [8.5] vs 7.3 [7.3]). DLQI scores were shown to be highest for those with psoriasis in the face (12.4 [8.9]), palms/soles (11.7 [9.0]), and genitals (11.7 [9.0]), followed by nails (11.6 [9.1]) and scalp (9.5 [8.4]).

Patients with involvement in 1 or more special areas were also more likely than those without special area involvement to report that their psoriasis had at least a moderate effect on QOL (DLQI 6; 57.9% vs 47.5%) and to have a positive depression screen (PHQ-2 3; 53.2% vs 44.1%).

A greater proportion of patients with psoriasis in 1 or more special areas (43.3%) had a DLQI scores of 6 or above and PHQ-2 of 3 or higher vs patients without special area involvement (32.8%).

Results of the UPLIFT survey underscore the additional QOL and psychological burdens of psoriasis for patients with special area involvement vs those without involvement in special areas, concluded the researchers.

The HRQOL impact on patients with psoriasis was further investigated by another analysis that assessed how improvements in Psoriasis Area and Severity Index (PASI) were associated with the achievement of DLQI 0/1 (no impact of skin disease on patients life).2

Pooled data from the initial 16-week periods of the BE SURE, BE VIVID, BE READY, and BE RADIANT phase 3/3b trials evaluating the use of several biologics in plaque psoriasis was included in the analyses.

Analyses included 2223 randomized patients with psoriasis who presented with a mean baseline PASI of 20.4 and a mean baseline DLQI of 10.7 (bimekizumab, n = 1362; placebo, n = 169; ustekinumab, n = 163; adalimumab, n = 159; secukinumab, n = 370).

Findings indicated that incremental PASI improvements translated to higher rates of patients achieving DLQI 0/1:

These data highlight the importance of complete skin clearance for patients with plaque psoriasis and suggest that for patients who respond to treatment, but do not achieve complete skin clearance, residual disease may still negatively impact HRQOL, said the researchers.

References

1. Langley RG, Augustin M, McBride S, et al. Impact of psoriasis in special areas on patient quality-of-life outcomes and depression screening: Findings from the multinational UPLIFT survey. Presented at: 2022 American Academy of Dermatology Annual Meeting; March 25-29; Boston, MA. Abstract 33950.

2. Blauvelt A, Lebwohl M, Gottlieb A, et al. Complete skin clearance for patients with moderate to severe plaque psoriasis: The relationship between improvements in Psoriasis Area and Severity Index and health-related quality of life. Presented at: 2022 American Academy of Dermatology Annual Meeting; March 25-29; Boston, MA. Abstract 33884.

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Quiz: Is Psoriasis Affecting Your Mental and Emotional Health? – Everyday Health

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Psoriasis may be a skin condition, but its impact is more than skin deep. Research has shown psoriasis can increase the risk of mental and emotional issues such as depression, anxiety, low self-esteem, and loneliness.

The condition characterized by itchy, discolored patches of skin that most often develop on the knees, elbows, and scalp can cause you to feel self-conscious about exposing your skin in public, says Ahmad Amin, MD, an assistant professor of dermatology at Northwestern Medicine in Chicago. This, in turn, can prevent you from participating in activities such as going to the gym or socializing with friends, which can lead to depression or anxiety.

The physical symptoms of psoriasis can lower your quality of life as well. When someone has psoriasis, the patches on the skin can be uncomfortable painful, itchy, and troublesome, explains Dr. Amin. The skin is often very flaky, and patients can shed excess skin [leaving] flakes on their clothes, on their desk, or on the floor.

Problem is, if youve been living with psoriasis for a long time, you may not realize how much the condition is impacting your mental and emotional health. Take this short quiz to find out and learn how to deal with any challenges it reveals.

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The Winding Road to Psoriatic Arthritis Relief – Self

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The results from the scan didnt fit in with any sort of injury, or any sort of wear and tear damage, and with a few other nagging bits in my history, it meant that I was referred straight to the rheumatology team, Wilson says. Despite inconclusive blood tests, Wilson was diagnosed with rheumatoid arthritis. It wasnt until she was 28 that she had what she describes as her largest breakthroughshe moved to another part of the country and saw a new doctor. A fresh pair of eyes meant my diagnosis changed to psoriatic arthritis, and with that my treatment changed too, she says.

Unlike Parker, Wilson doesnt have skin psoriasis, which is possible (though less common) and another factor that may contribute to a delayed diagnosis. In some cases, PsA symptoms may present before the skin symptoms show up, especially in young patients, Dr. Fors Nieves adds. The skin psoriasis may also be present in less visible parts of the body, like the scalp, under the arms, or on the groin or genitals.

The first hurdle of treatment is typically finding the right specialist, which can be a struggle for some. While Parkers first rheumatologist wasnt the right fit, she eventually found a provider she felt comfortable with. I wanted someone who I could relate to and feel heard, she says. I wanted to see someone who understood a person of color may have different experiences with medical staff, and a professional who knew how to communicate with me in a way that was helpful and hopeful.

The next step is finding a treatment method that works for you. In the decade since she first saw a doctor for her joint pain and swelling, Wilson has tried several different treatments with varying levels of success. A few years ago, she underwent arthroscopic surgery to try to reduce some of the inflammation of her knee joint. Wilson says it helped for a while, but it certainly wasnt a cure. She currently manages her condition with a combination of anti-inflammatory medications, biologic injections, exercise, and sleep.

Early and mild PsA is often treated with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. For some patients, sporadic use of these medications is sufficient to control their symptoms, Dr. Fors Nieves says. But in more severe cases, and in patients who are experiencing joint damage from the inflammation, stronger medications are often required.

In the case of a patient who is having regular flares with attacks of swollen joints and severe stiffness, we may need to add immunomodulatory medication since PsA is an autoimmune condition, says Dr. Fors Nieves. These might include conventional disease-modifying antirheumatic drugs (DMARDs), biologics, or enzyme inhibitors.

Some patients may require multiple medicines to have their skin and joint disease under control, Ronald Yglesias, MD, a rheumatologist in Aventura, Florida, tells SELF.

Managing this condition isnt just about taking medicationslifestyle changes can actually be life-changing for people with PsA. The key is listening to your body to get an idea of what it needs (or what it really needs a break from.) For instance, Wilson started to cut back on alcohol when she realized it was a major trigger for pain and stiffness the next morning.

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Arcutis Completes Enrollment in ARRECTOR Pivotal Phase 3 Trial of Topical Roflumilast Foam in Scalp and Body Psoriasis – GlobeNewswire

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WESTLAKE VILLAGE, Calif., April 06, 2022 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc.(Nasdaq: ARQT), a late-stage biopharmaceutical company focused on developing meaningful innovations in immuno-dermatology, today announced the enrollment of the last subject in its ARRECTOR pivotal Phase 3 trial of topical roflumilast foam in adolescents and adults with scalp and body psoriasis. Roflumilast foam is a once-daily, topical formulation of a highly potent and selective phosphodiesterase-4 (PDE4) inhibitor (roflumilast). The foam formulation was designed to treat all areas of the body, including the face and particularly hair-bearing areas such as the scalp. If successful, the Company believes that this trial will provide sufficient basis to file a supplemental New Drug Application (sNDA) in the U.S. for roflumilast foam in scalp and body psoriasis.

Scalp psoriasis occurs in approximately 40% of individuals with plaque psoriasis and can cause physical and emotional distress, with 97% of individuals with scalp psoriasis reporting that the condition impacts their daily life.i

The scalp and hair-bearing areas of the body create unique treatment challenges, not easily solved through creams or ointments, and often requiring patients to use multiple therapies, complicated treatment regimens or resort to expensive systemic or biologic therapies. This can result in lack of compliance to treatment and worsening symptoms. Roflumilast foam has been formulated to overcome these challenges and provide a once-daily treatment option for use on all areas of the body, said Patrick Burnett, MD, PhD, FAAD. We are proud of the continued execution of our clinical development program as demonstrated by the completion of enrollment in a second pivotal phase 3 program for roflumilast foam this year. More importantly, we move one step closer to providing an important treatment option to millions of individuals impacted by scalp psoriasis.

About ARRECTORThe A Randomized tRial Employing topiCal roflumilasT foam to treat scalp psORiasis (ARRECTOR) study is a parallel group, double blind, vehicle-controlled pivotal Phase 3 study of the safety and efficacy of roflumilast foam 0.3% or a matching vehicle administered once-daily in subjects with scalp and body psoriasis ages 12 and older. A total of 432 subjects have enrolled in the study. The co-primary endpoints of the study are the proportion of subjects achieving Scalp-Investigators Global Assessment (IGA) success and the proportion of subjects achieving Body-IGA success, with IGA success defined as an IGA score of clear or almost clear plus a 2-point improvement from baseline after eight weeks.

About Scalp and Body PsoriasisScalp psoriasis is a manifestation of plaque psoriasis characterized by raised, red areas of skin (plaques) covered with a silver or white scale that occurs in the hair-bearing area of the scalp and sometimes extending to the forehead, back of the neck, or behind or inside the ears. Patients with scalp psoriasis commonly have plaques on other areas of the body as well. Approximately 40 percent of the estimated 8.6 million Americans with plaque psoriasis have involvement of the scalp. Scalp psoriasis plaques are identical to psoriatic plaques on other areas of the body; however, topical treatment of scalp plaques is complicated by the difficulty of delivering topical drugs under the hair and onto the skin. As with psoriatic plaques on other parts of the body, psoriasis on the scalp is often itchy and is sometimes painful. Scalp psoriasis can also be associated with hair loss, likely due to damage to the hair from excessive scratching, rubbing, or combing of the affected area. Often, patients require two or more medications to manage their disease when they have scalp involvement.

About Topical Roflumilast Foam Topical roflumilast foam is a once-daily, topical formulation of a highly potent and selective PDE4 inhibitor (roflumilast), which the Company is developing for both seborrheic dermatitis and scalp and body psoriasis. The unique foam formulation is designed to penetrate and treat inflammatory dermatoses in hair-bearing areas of the body, such as the scalp, although it is usable on all areas of the body. Arcutis has also submitted a New Drug Application (NDA) for a closely related cream formulation of topical roflumilast for the treatment of plaque psoriasis, with a Prescription Drug User Fee Actaction date of July 29, 2022. Roflumilast has been approved by the U.S. Food and Drug Administration (FDA) for oral treatment to reduce the risk of exacerbations of chronic obstructive pulmonary disease (COPD) since 2011. PDE4 is an intracellular enzyme that increases the production of pro-inflammatory mediators and decreases production of anti-inflammatory mediators; it has been implicated in a wide range of inflammatory diseases including psoriasis, atopic dermatitis, and COPD. PDE4 is an established target in dermatology, and other PDE4 inhibitors have been approved by the FDA for the topical treatment of atopic dermatitis and the systemic treatment of plaque psoriasis.

About ArcutisArcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a medical dermatology company that champions meaningful innovation to address the urgent needs of patients living with immune-mediated dermatological diseases and conditions. With a commitment to solving the most persistent patient challenges in dermatology, Arcutis harnesses our unique dermatology development platform coupled with our dermatology expertise to build differentiated therapies against biologically validated targets. Arcutis dermatology development platform includes a robust pipeline with multiple clinical programs for a range of inflammatory dermatological conditions, with one NDA under review with the FDA and three Phase 3 clinical data readouts anticipated by the end of 2022. The companys lead program, topical roflumilast, has the potential to advance the standard of care for plaque psoriasis of the body and scalp, atopic dermatitis, and seborrheic dermatitis. For more information, visitwww.arcutis.comor follow Arcutis on LinkedIn and Twitter.

Forward-Looking StatementsThis press release contains "forward-looking" statements, including, among others, statements regarding the potential for roflumilast to be approved for the treatment of adults and adolescents with scalp and body psoriasis, the potential to use roflumilast foam over a long period of time, or chronically, the potential to use roflumilast foam anywhere on the body, including the face and scalp, and the potential for roflumilast to advance the standard of care in scalp and body psoriasis and other inflammatory dermatological conditions. These statements involve substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements and you should not place undue reliance on our forward-looking statements. Risks and uncertainties that may cause our actual results to differ include risks inherent in the clinical development process and regulatory approval process, the timing of regulatory filings, and our ability to defend our intellectual property. For a further description of the risks and uncertainties applicable to our business, see the "Risk Factors" section of our Form 10-K filed with U.S. Securities and Exchange Commission (SEC) on February 22, 2022, as well as our subsequent filings with the SEC. We undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.

Contacts:MediaAmanda Sheldon, Head of Corporate Communicationsasheldon@arcutis.com

InvestorsEric McIntyre, Head of Investor Relationsemcintyre@arcutis.com

i Crowley J. Scalp psoriasis: an overview of the disease and available therapies. J Drugs Dermatol. 2010 Aug;9(8):912-8. PMID: 20684141.

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Arcutis Completes Enrollment in ARRECTOR Pivotal Phase 3 Trial of Topical Roflumilast Foam in Scalp and Body Psoriasis - GlobeNewswire

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