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Monthly Archives: July 2021
Camilla to take on unprecedented title with Charles ascension to throne – The News International
Posted: July 18, 2021 at 5:19 pm
Camilla to take on unprecedented title with Charles' ascension to throne
Duchess of Cornwall Camilla will be taking on an unprecedented title when Prince Charles becomes the King of England.
Although, the wife of a king usually gets the title of Queen Consort, Camilla will use one that has never been used before.
At the time of Camilla's marriage to Charles in 2005, an official statement said it is "intended that The Duchess will be known as HRH The Princess Consort."
Meghan Markle and Harry want to have their daughter christened at Windsor: report
Meanwhile, royal expert Robert Jobson said Camilla will be considered the Queen because he believes the word 'intended' was used in the original wording of the statement to give the public time to warm to her.
Prince Williams sneaky tactics show jealousy towards Prince Harry
"The critical word in this statement, of course, was 'intended'. What Clarence House was doing was buying time time for a hostile public to warm to Camilla," Jobson wrote in his book Charles at 70: Thoughts, Hopes And Dreams.
Royal commentator says nomination of Meghan Markle, Harry's interview for Emmy seems strange
"Prince Charles, however, has always intended her to become his queen consort. According to an inside source, he'd already decided that before their wedding," he added.
Duchess of Cornwall Camilla will be taking on an unprecedented title when Prince Charles becomes the King of England.
Although, the wife of a king usually gets the title of Queen Consort, Camilla will use one that has never been used before.
At the time of Camilla's marriage to Charles in 2005, an official statement said it is "intended that The Duchess will be known as HRH The Princess Consort."
Meghan Markle and Harry want to have their daughter christened at Windsor: report
Meanwhile, royal expert Robert Jobson said Camilla will be considered the Queen because he believes the word 'intended' was used in the original wording of the statement to give the public time to warm to her.
Prince Williams sneaky tactics show jealousy towards Prince Harry
"The critical word in this statement, of course, was 'intended'. What Clarence House was doing was buying time time for a hostile public to warm to Camilla," Jobson wrote in his book Charles at 70: Thoughts, Hopes And Dreams.
Royal commentator says nomination of Meghan Markle, Harry's interview for Emmy seems strange
"Prince Charles, however, has always intended her to become his queen consort. According to an inside source, he'd already decided that before their wedding," he added.
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Mystery Sisters: The Ultimate Guide to a Successful Ascension Journey – Roanoker
Posted: at 5:19 pm
We are having an experience on earth that feels sticky, scary, and segregated.
Life is not the same. We feel it even IF we avoid TV, social media, the radio, and newspapers!
It is time to change directions from what is known and comfortable to pursuing a life of deep satisfaction. NO regrets at the end of our lives! We hold ourselves back from our true passion and abundance because we don't believe in ourselves and afraid of what might happen if we take risks.
The Mystery Sisters can help you get through these changes!
What is the ascension? Why does it matter that you ascend? What happens if you don't?
Some people won't ascend. AND they will continue feeling foggy, achy, exhausted, confused, frustrated.... feel toxic and gain weight.
In this workshop you will learn how to discover your abundance potential and intuitive gifts!
You WILL go through a process of releasing old toxic patterns. What then? Crystal clear, motivated, and tapped in to what is possible. You will be given a workbook to keep.
I assure you that you cannot and do not want to go back to the way things were!
It will be a truly beautiful outcome for your future self!
It is $97. It's a steal at $97. We have spent 100's of hours studying and putting into practice what we will be teaching.
There are several ways of paying. Credit card, Square, Cash app, paypal or venmo (just ask)
checkout.square.site/merchant/0V810HJ7331KN/checkout/YMYN3TNFZJ26FVDM3BWNGAED
For more information - email rkeen1034@gmail.com or maurie897@gmail.com
Attendees (3)
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Mystery Sisters: The Ultimate Guide to a Successful Ascension Journey - Roanoker
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Oakland University Announces the Winners of the 33rd Annual Nightingale Awards for Nursing Excellence – 2021 – Nursing – News – OU Magazine – News at…
Posted: at 5:19 pm
Oakland Universitys School of Nursing and its Board of Visitors have announced the 2021 Nightingale Award winners and runners-up. This years top nurses in Michigan come from a variety of clinical roles and settings and are recognized as exceptional in their various nursing roles.
The invaluable role nurses play in healthcare has been made more apparent than ever this past year during the pandemic. These annual awards honor nurses at a time when its never been more important to celebrate the profession and acknowledge our gratitude for the crucial role nurses play in our society.
Thanks to generous support from Presenting Sponsor: Ascension Michigan, along with other sponsors, individual donations and support from the School of Nursing Board of Visitors; The Nightingale Awards provides future nurses with scholarships; like the Nightingale Legacy Scholarship. This endowed scholarship will be awarded annually to nursing students who display the pioneering spirit of Florence Nightingale.
We take our mission of educating and helping to create top nurses in Michigan very seriously, says OU School of Nursing Dean, Judy Didion, Our goal is to create more nurses who emulate the spirit and tenacity of Florence Nightingale -- innovative, passionate nurses who can change the world.
The Nightingale Awards event will be on Thursday, September 2 at the Meadow Brook Amphitheatre on OU's campus in Rochester Hills. Each of the 12 Nightingale Award winners will receive a check for $1,000, a solid bronze statue of Florence Nightingale and a Nightingale ceremonial pin. Runners-up will be honored on stage as well and receive a commemorative plaque. Nominees were nominated by their peers, supervisors, and patients in recognition for their superior nursing expertise.
For more information on the event, please contact Kate Lionas in OU School of Nursing at 248-364-8723 or by email at nightingale@oakland.edu or visit oakland.edu/nursing/nightingale.
2021 Nightingale Award Winners & Runners Up:
Excellence in Advanced Practice Nursing
Winner: Ann Marie Ramsey, University of Michigan Health System, Northville, MIRunner-Up: Shawn Gauvin, Ascension Providence Hospital, Brownstown, MI
OU School of Nursing Distinguished Alumni
Winner: Kathryn Armstrong, Beaumont Hospital-Royal Oak, Clarkston, MIRunner-Up: Gilda Wong, Beaumont Hospital-Royal Oak, Redford, MI
Excellence in Education
Winner: Nancy Tena, University of Michigan Health System, Ann Arbor, MIRunner-Up: Susan Karasinki, St Joseph Mercy Hospital, Garden City, MI
Excellence in Research
Winner: Cheryl Larry-Osman Bellamy, Henry Ford Hospital-Detroit, Oak Park, MIRunner-Up: Karen Dunn, Oakland University School of Nursing, Riverview, MI
Excellence in Nursing Leadership
Winner: Lori Lesner, DMC/Rehabilitation Institute of Michigan, Waterford, MIRunner-Up: Marleen Nowakowski, McLaren Macomb, St. Clair, MI
Executive Administration
Winner: Gwen Gnam, Henry Ford Hospital-Detroit, Wyandotte, MIRunner-Up: Jennifer Dunn, St Joseph Mercy Hospital - Ann Arbor, Milan, MI
Nursing in the Community
Winner: Calandra Green, Oakland County Health Division, Pontiac, MIRunner-Up: Lisa Marie Levy, Ascension Providence Novi & Southfield, Dearborn, MI
Post-Acute Care & Specialty Nursing
Winner: Sharron Alejandria, Henry Ford Hospital, Windsor, Ontario, CARunner-Up: Eileen Blodgett, Beaumont Hospital-Troy, Shelby Township, MI
Staff Nurse (2)
Winner: Noel Baldwin, University of Michigan Health System, Chelsea, MIWinner: Michelle Turmell, Henry Ford Hospital-Detroit, Canton, MIRunner-Up: Tami Kirn, Children's Hospital of Michigan, Livonia, MIRunner-Up: Sandra Pardington, Beaumont -Royal Oak, West Bloomfield, MI
COVID Hero-Staff Nurse Award
Winner: Kelly Schroeder, Henry Ford Hospital-Macomb, Chesterfield, MIRunner-Up: Sandy Sharp, McLaren Macomb Hospital, Clinton Township, MI
Peoples Choice Award
Winner: Irina Ghinescu, Henry Ford Hospital- Macomb, Leonard, MIRunner-Up: Patricia Danieleski-Grabowski, Henry Ford Hospital-Detroit, Harrison Township, MI
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What if the Milwaukee Bucks had been allowed to sign Jeff Teague in 2013? Would they have Khris Middleton today? – Milwaukee Journal Sentinel
Posted: at 5:19 pm
It seems entirely possible that Khris Middleton's ascension with the Milwaukee Bucks wouldn't have happened without Milwaukee missing out on the player itreallywanted Jeff Teague.
Now Middleton's teammate on the Bucks and a player who has seen minutes in the NBA Finals, Teague was a target in 2013 for Bucks general manager John Hammond. The Bucks signed the restricted free agent Teague to a four-year, $32 million offer sheet, signaling they were prepared to move on from their own restricted free agent, Brandon Jennings.
More: When the Bucks were awful on offense, Khris Middleton takes over to save the day
More: Bucks 109, Suns 103: Khris Middleton outduels Devin Booker to even NBA Finals at 2-2
More: These are Khris Middleton's greatest playoff performances for the Milwaukee Bucks
But the Hawks, in a bit of a surprise move, matched the offer, and the guard returned to Atlanta. Milwaukee was forced to look at other optionsand, two weeks later, they swung a trade with Detroit for another point guard, Brandon Knight. It was a trade that included a second-year shooting guard named Khris Middleton.
Teague, who had just turned 25 years old, wanted to reunite with his former Hawks coach, Larry Drew, who'd been hired for his first (and, as it turnedout, only) season in Milwaukee. The Hawks had moved on to a new coach ... a guy you may have heard of named Mike Budenholzer.
Teague's comments indicated that he hoped (and perhaps expected) Atlanta to decline the offer match, which would return him to his previous team as per the tenets of restricted free agency.
"I'm definitely excited at the opportunity to come back to work with Larry Drew," Teague said at the time. "The Bucks have a good team, a young nucleus and guys that are ready to take the next step."
Said Teague's Indianapolis-based agent, J.R. Hensley,"I think after one call he knew this is where he wanted to be. He's familiar with Larry already and that's the icing on the cake. They can continue to grow together.
"It's a new challenge. It's just refreshing to be part of an organization that sees him as a building block for the future."
Hensley said Teague was frustrated by the Hawks' lack of sincere interest and phoned team president and general manager Danny Ferry to inform him he did not want to return to Atlanta.
"I'm nervous," Teague said of the 72-hour window in which Atlanta had to makeits decision. "I really want to be here. I thank Milwaukee for giving me this opportunity and taking a chance on me."
Atlanta's backcourt options were limited, and Ferry pulled the trigger to bring Teague back. It proved to be a shrewd move when Teague made the all-star team in 2014-15. He averaged 16 points and 6.5 assists over his next three seasons with the Hawks.
More: Charles Barkley botches one on TNT before the Bucks-Hawks game
More: Get to know Milwaukee Bucks backup guard Jeff Teague, who played for the Atlanta Hawks
After bouncing around to Indiana, Minnesota, Atlanta again, Boston and briefly with Orlando (under Hammond, who released Teague after acquiring him), the point guard finally signed with the Bucks this year to play for his old coach in Atlanta just not Drew.
Oh, and he scored 11 points in a Game 6 win in Atlanta that gave the Bucks a 4-2 series win over his old team. More on "Bucks in 6" in a moment.
With the bad news coming on July 14 that the Hawks had retained Teague, Milwaukee was back to square one with an unhappy Jennings,who had averaged 17.5 points and 6.5 assists per game the previous season.
Monta Ellis had already signed with Dallas, and backup guards J.J. Redick and Mike Dunleavy had also moved on. Milwaukee was facing a rebuild, and Hammond had previously indicated he would likely match any offer for the 23-year-old Jennings and bring him back. But would he be happy?
On July 30, Milwaukee announced it had a deal in principle with the Detroit Pistons, a sign-and-trade in which Jennings would head to Detroit for point guard Brandon Knight, center Viacheslav Kravstov and Middleton. Milwaukee signed Jennings to a three-year, $24 million deal.
It's a deal that has worked out dramatically, but not in a way the Bucks expected.
Milwaukee was now headed into 2013 with just five holdovers: Larry Sanders, John Henson, Ersan Ilysova, Epke Udoh and Ish Smith. The team added new veterans like O.J. Mayo, Zaza Pachulia, Carlos Delfino and LukeRidnour.
Ridnour, Knight, second-round pick Nate Wolters and Smith were now the point-guard options.Knight had been the eighth overall draft pick in 2011 and had two more seasons on his rookie-scale deal. He'd averaged 13.3 points and 4.0 assists in 75 starts the year before, with a shooting mark of 40.7%.
Knight would go on to lead the Bucks in scoring the next two seasons. But he's not the reason the trade will be remembered.
Middleton, a second-round pick out of Texas A&M, averaged 6.1 points in 27 appearances with the Pistons as a rookie, but that was misleading. He'd torn his meniscus in his final year of college, an ailment that dropped him from a potential lottery pick to 39th overall in the 2012 second round. He did however, flash some potential with Detroit late in the season.
Middleton notably became the first NBA all-star to have played any time in the NBA G-League (D-League at the time), but that's also a little misleading; he played in only three games for the Fort Wayne Mad Ants in 2012 as a rookie.
Middleton emerged quickly as a top option for the Bucks, making 64 of 82 starts that 2013-14 season and appearing in every game. His ascension meant fewer opportunities for Racine native and veteran Caron Butler.
"Now I'm concentrating on my whole body and not just focusing on one part," Middleton said. "I'm not thinking about it anymore. I'm over the knee phase where I just go out there and play, not worry about it.
"It was tough not playing (as a rookie). It was a reality check that I still have to put the work in and keep improving. I think it definitely helped me out to finally get that (rotation) spot at the end of the year."
Drew even began drawing up late-game shots for Middleton. He had his foot on the 3-point line for an overtime would-be tying shot that could have forced another extra period butinstead left the Bucks with a 111-110 loss to Charlotte, but the potential was there. It seems likely the Pistons would have realized what they had soon enough.
Middleton averaged 12.1 points per game in 2013-14, third on the team behind Knight and Ramon Sessions.
Though the story is still being written, it only gotbetter from there. Jennings eventually came back to Milwaukee, too, in 2018 and re-affirmedhis famous brash "Bucks in 6" prediction that has become a rallying cry for Milwaukee Bucks fans.
If Milwaukee indeed wins this NBA Finals in six (or seven, for that matter), Middleton will be a chief reason why.
JR Radcliffe can be reached at (262) 361-9141 or jradcliffe@gannett.com. Follow him on Twitter at @JRRadcliffe.
Our subscribers make this reporting possible. Please consider supporting local journalism by subscribing to the Journal Sentinel at jsonline.com/deal.
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Baton Rouge man arrested in fatal hit-and-run on Joor Road – The Advocate
Posted: at 5:19 pm
A 47-year-old Baton Rouge man was arrested after he fled the scene when he struck and killed a pedestrian with his car last week, police said.
The crash took place July 8 just before 2 a.m. on Joor Road at the intersection of Mickens Road in East Baton Rouge Parish, according to Trooper Taylor Scrantz, State Police spokesperson. David Copening, 41, of Baton Rouge, died after he was struck by an unknown vehicle while walking along the road.
After an investigation, State Police arrested Shawn Andre on Monday, saying he was the driver of the vehicle, Scrantz said.
Andre faces charges for crimes allegedly committed in both Ascension and East Baton Rouge Parishes.
In Ascension, he faces charges of: obstruction of justice, two counts of battery of a dating partner, one count of filing false public records, one count of telephone communications; improper language; and harassment.
Troopers took Andre into custody and booked him into the Ascension Parish Jail on Monday.
In East Baton Rouge he faces one count of hit and run and one count of obstruction of justice.
When he is released from the Ascension Parish Jail, Andre will be booked into the East Baton Rouge Parish Prison on those counts.
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Here’s Who’s Running For CA Governor In The Upcoming Recall Election, So Far – LAist
Posted: at 5:18 pm
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Californias next governor could be a retired homicide detective, a marijuana reform advocate, or an Olympic champion.
Or, a former Mayor of San Francisco who went on to win the Governor's office a few years ago.
The state on Saturday released a list of 41 people who filed the required paperwork to run in the Sept. 14 recall election that could remove Gov. Gavin Newsom. The lineup includes 21 Republicans, eight Democrats, one Libertarian, nine independents, and two Green Party members.
Voters may be familiar with several names on the list, including Caitlyn Jenner, the former Olympian turned reality TV personality; and John Cox, the Orange County businessman. Other, perhaps lesser-known candidates include Democrat Kevin Paffrath, 29, a YouTube financial advisor; Libertarian Jeff Hewitt, 68, a Riverside County supervisor, and Republican Sam Gallucci, 60, a former executive at the financial management firm PeopleSoft and current pastor at an Oxnard church.
See all 41 candidates: Whos Running In Newsom Recall? Politicians, Activists, Californians Of All Stripes
The number of candidates is smaller than some analysts expected; predictions at one point ran up to 100. That could be a setback for recall supporters who had hoped for a large, prominent field to attract voters for the first question of whether or not Newsom should be recalled.
If that question fails, the recall is over and Newsom remains in office, mooting the candidates on the second ballot.
A certified list the one voters will see will be released Wednesday and changes are possible.
What questions do you have about Southern California?
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Here's Who's Running For CA Governor In The Upcoming Recall Election, So Far - LAist
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Opinion: The parties to political irrelevance – Juneau Empire
Posted: at 5:18 pm
By Rich Moniak
On Monday, oral arguments were heard on an election lawsuit ripe with irony. It seeks to invalidate Alaskas new voting law for statewide offices that narrowly passed last November. Proposition 2 created a nonpartisan primary that advances the top four vote-getters to a ranked-choice competition in the general election.
The plaintiffs are Kenneth Jacobus, a registered Republican and the attorney who filed the lawsuit; Scott Kohlhaas, a member of the Alaska Libertarian Party; The Alaskan Independence Party; and Bob Bird, AIPs chairman.
The complaint Jacobus submitted describes how the non-partisan primary stripped all three parties of their ability to control the selection of candidates in Alaskas elections. In doing so, he argues, Proposition 2 violates their rights to free political association and creates a system in which political parties are rendered irrelevant.
Now Im not a fan of our two-party duopoly, but the Alaskan Independence Party and Alaska Libertarian Party are already irrelevant. Combined, they account for only 4.3% of all registered voters in Alaska. In 2020, the two parties nominated a total of six candidates for 32 statewide offices. They all lost by huge margins. Their record for the prior decade is just as bad.
If their candidates cant do any better in a nonpartisan primary, then Proposition 2 does nothing more than reschedule their embarrassing showing from November to August.
Kohlhaas has personal experience in the art of political irrelevance. He lost two state House races by more than 40 points. And in his 2014 bid to be our U.S. senator, he finished third with just 14% of the vote in his partys primary. Its worth noting that the winner of that got under 4% in the general election.
Before that, Kohlhaas filed lawsuits against the state for refusing to certify two ballot initiatives he proposed. Both were about giving Alaskans the choice to secede from the union. Jacobus, who represented him both times, took his appeals to the state Supreme Court where they were unanimously rejected.
Their record as a team suggests this is just another a crank lawsuit. Which is probably why the GOP opted out. But because it serves the GOPs desire to limit who can appear on the general election ballot, its leadership is hoping Kohlhass and Jacobus prevail this time.
The irony here is thethe Alaskan Independence Party and Alaska Libertarian Party are to the political right of the GOP. So, if the court strikes down Proposition 2, general election candidates from both parties will continue syphon off a small percentage of conservative voters. Twice in the past 10 years, the loss of those votes resulted in a narrow defeat for Republican House candidates.
Because the top four vote-getters advance to the general election though, its unlikely theyll be spoilers in the primary. Indeed, as the plaintiffs argue, all four are likely to be Democrats or Republicans.
But with the GOP becoming little more than a cultish allegiance to former President Donald Trump, it doesnt want a principled Republican like Sen. Lisa Murkowski on the general election ballot.
Murkowski earned Trumps wrath a year ago for agreeing with the blistering criticism of him by his former Secretary of Defense. And again after she voted to convict him during his second impeachment trial.
Murkowski has got to go! Trump said last month when he endorsed Kelly Tshibaka for the Senate.
Tshibaka thinks its time to replace Lisa with an Alaskan who is not a Washington, D.C., insider politico. And claims to have a fire in my heart to rebuild Alaska.
Those are amusing statements coming from a Harvard Law graduate who spent 17 years climbing the bureaucratic ladder in Washington, D.C., before returning to Alaska in 2019.
But rather than recruit a candidate with a real Alaskan resum, the GOP bowed to Trumps preference and grievances by endorsing her last week.
Tshibaka would probably beat Murkowski in a traditional primary because the voices of nonpartisan and nonaffiliated Alaskans are irrelevant. But they outnumber the combined registration of all three conservative parties 2-to-1. If the courts uphold Proposition 2, theyll help Murkowski finish in the top four.
And if she wins election, the GOP leaders who bet on Trump and Tshibaka will be free to associate with their party while finding a place alongside Kohlhaas in ranks of the politically irrelevant.
Rich Moniak is a Juneau resident and retired civil engineer with more than 25 years of experience working in the public sector. Columns, My Turns and Letters to the Editor represent the view of the author, not the view of the Juneau Empire. Have something to say? Heres how to submit a My Turn or letter.
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The yoga and wellness worlds have a conspiracy problem – Vox.com
Posted: at 5:18 pm
There is a type of all-natural Instagram influencer who, at first glance, appears to be all about living her best, healthy life. She is an avid proponent of meditation, clean eating, yoga, and a vague form of Asian spirituality. Her approach to life and health is holistic. And her social media feeds are a whiplash of content, ranging from the benefits of gua sha and ayurvedic diets to her skepticism about the effectiveness of masks and vaccines.
Over the past year of the pandemic, the wellness space a blanket term used to describe practitioners and promoters of noninstitutionalized Western medicine, from crystal healers to yoga teachers has grown rife with politically motivated misinformation on QAnon, Covid-19, the prevalence of child trafficking, and election integrity.
Media coverage has largely centered on these New Age-type influencers as peddlers of a libertarian, anti-science ideology that refuses masks, social distancing, and vaccines. Californias yoga, wellness and spirituality community has a QAnon problem, read a recent Los Angeles Times headline. Wellness influencers are spreading QAnon conspiracies about the coronavirus, declared Mother Jones. In March, the Washington Post wrote about QAnons unexpected roots in New Age spirituality.
These articles explore a concerning facet of American life, a phenomenon researchers call conspirituality, or how conspiracy theories have found a home in spiritual circles that are skeptical of Western medicine and established institutions. The observations stop short of implying that certain practices, like yoga, are a direct pathway to radicalization. Blame is generally assigned to the wellness communities where these fringe, anti-science ideas comfortably fester. Still, while most coverage identifies the prevalence of these dangerous, unfounded beliefs accurately, there is often little context on the wellness spaces relationship with Orientalism (or the Wests tendency to romanticize, stereotype, and flatten Asian cultures) and libertarian individualism.
For decades, many health and medicinal practices have been exported from Asia to the West, including yoga, ayurveda, reiki, and aspects of traditional Chinese medicine such as cupping, gua sha, and acupuncture. Such traditions are often categorized under the alternative medicine or New Age umbrella vague terms that conflate different philosophical and medical systems into a uniquely Western mishmash of ideas. The nuance and history of these traditions, however, dont exactly get first billing when they go viral.
Cultural exports are a complex, inevitable result of globalization, and cultural appropriation doesnt always carry negative effects. As Asian-inspired practices and treatments edge toward the mainstream, the problem isnt necessarily appropriation. Its what appropriation can produce: an Orientalist perspective toward non-Western practices that can be misrepresented to further a political agenda.
The process by which this happens is likely familiar to anyone with a passing knowledge of Gwyneth Paltrows Goop, although this type of appropriation predates the brand by decades. It usually begins with an influential (usually white) Westerner who encounters a practice with origins in East or South Asia. The person integrates the tradition into their lifestyle, publicly touts its benefits, and helps disseminate a version of the practice to their own community. (Such was the case for acupuncture in 1971, after a New York Times reporter wrote about the benefits of his treatment in China.)
Its New Age capitalism at work: A robust system of knowledge is taken apart piecemeal, divorced from any philosophical or religious roots, and transfigured into a commodity, something that can be bought and sold to improve consumers lives. For example, gua sha is a traditional Chinese treatment that has recently gone viral online. It is intended to be a scraping treatment for a persons back and body, rather than the face. Yet, the beauty industry markets gua sha stones and jade rollers, another Chinese-inspired facial tool, as beautifying gimmicks a way to contour ones jawline and mimic the results of a facelift instead of contextualizing their traditional use.
Social media has, for better or worse, popularized these once-niche practices to a broader American audience. And the pandemic has facilitated this consumer interest. Stuck at home in the event of a novel disease, millions of people took to fretting over their health and well-being as the American health care system buckled. People turned to yoga, meditation, and essential oils, in addition to spiritual practices such as astrology, reiki-inspired crystal healing, and manifestation. Amid this social upheaval, some gravitated toward the alternative and sought out unorthodox theories to explain their uncertain reality.
The thing about the spiritual East or the Orient is that theres a history of Westerners cherry-picking customs, traditions, and practices to serve their needs, that they can tie to a particular political agenda, said Shreena Gandhi, an assistant professor of religion at Michigan State University who researches yoga and its history of appropriation. There are multiple aspects of Orientalism at play here. Theres the romantic approach to Eastern wellness and alternative therapies, and its hysterical counterpart, which is fearful or distrustful of traditional beliefs.
Nazi leaders, for one, were proponents of yoga and its spiritual philosophy; they were obsessed with purifying and elevating an individuals body as a microcosm of the nation-state. Modern-day wellness communities appear much more focused on the individual (without mentioning the state), but according to Matthew Remski, journalist and co-host of the Conspirituality podcast, there are lingering fascist undertones in New Age beliefs.
New-Agers are not secretly Nazis, Remski wrote in a four-part blog on yoga and conspirituality. Its more like: fascist ideas of the perfected body and earth [have] generated enduring cultural memes for holism, embodied spirituality, and health. Those memes, sanitized of their explicit politics, carry jagged edges of perfectionism and paranoia about impurity. And that double message your body is divine but it is also under attack has become standard in the commodification of yoga and wellness.
Its common for believers of conspirituality to reference South or East Asian religions and teachings. It lends to the appearance of gravitas, history, and authority, Remski told me. Its a positive Orientalism that has nothing to do with the actual practice or history involved.
In February, for example, a holistic facialist in Miami Beach made an Instagram post suggesting that wearing a mask blocks the flow of Lung Qi, borrowing language from traditional Chinese medicine on qi, or energy, that flows through the human body. This claim, while false, relies on a Western tendency to approach Eastern medicine erroneously, from a universal perspective. Its a type of medical Orientalism that exoticizes non-Western practices and caters to New Age notions of mystical, natural healing.
The onset of the coronavirus in Asia has polarized perceptions of Eastern medicine and alternative therapies, hardening a sense of scientific dualism in Asia and abroad that people, particularly its practitioners, are either pro- or anti-science. (Government officials in India, for example, have received backlash for encouraging the treatment of Covid-19 primarily with traditional medicine.) At the same time, souring US-China relations have fomented sinophobic distrust and paranoia toward Asian Americans, regardless of their citizenship status and ethnic heritage. Some believed these attitudes were fueled by Asias, specifically Chinas, initial association with the coronavirus outbreak.
It becomes political. Its easy to associate anyone who promotes or practices Chinese medicine as a mouthpiece for the Chinese Communist Party, said Michael Stanley-Baker, a historian of Chinese medicine at Nanyang Technological University in Singapore. My opinion is that biomedicine and scientific research is good and authoritative. That shouldnt discredit other knowledge systems. Chinese medicine is a systematic, robust form of knowledge that isnt static. Its not anything goes, and it certainly isnt random.
The professionalization of certain fields of alternative medicine, like acupuncture and ayurveda, has standardized such practices in the West to an extent. But these treatments have plenty of skeptics, and are often dismissed as useless at best and harmful at worst. At the same time, this standardization process in the US has marginalized and even led to arrests of Asian American practitioners, argued Tyler Phan, a lecturer at the University of Pittsburgh, in his doctoral thesis on American Chinese medicine.
Meanwhile, todays wellness industry attracts a demographic of predominantly white, middle-class adherents. According to a 2017 Pew Research Center survey, roughly six in 10 American adults, regardless of their religious affiliations, believe in at least one New Age belief, such as psychics, astrology, and spiritual energy in objects.
This tendency toward the spiritual, according to Remski, is perhaps a replacement for community. He attributes it to a cultural emptiness at the heart of alternative spirituality and modern-day yoga, which coincides with the breakdown of community and health care in the US. As a result, the modern yoga studio and by extension, the greater wellness world became devoid of politics. Its siloed outlook focused on an individuals religious potential and spiritual well-being at the expense of the collective. What appears to be countercultural then becomes quite similar to libertarianism, Remski said. That spiritually libertarian attitude has permeated yoga culture through its boom cycle.
And so long as conspiracy theories persist, the redpilling will continue on Instagram, in yoga studios, and in other wellness-related spaces. Yet, according to MSUs Gandhi, there is some hysteria surrounding the stereotype of a wealthy, yoga-practicing mother who refuses to vaccinate her kids. Its not only wellness and yoga practitioners who believe in this ideology, she said. Its more than just yoga classes. QAnon is an explicitly political conspiracy rooted in white supremacy.
This hysteria, Gandhi added, is reminiscent of the attitudes that fueled the yellow peril of decades past. This sentiment isnt entirely explicit, but the fixation toward flawed, New Age-y notions of wellness often lumps together alternative, Eastern therapies and practitioners into one broad group. As a result, these practices become collectively vilified and politicized for indoctrinating vulnerable Americans.
This conflation is not only unhelpful, but also dismissive of the work and history of non-Western knowledge systems that are valuable and complex in their own right. It also makes it harder for authoritative figures to debunk false information. There should be a nuanced middle ground, Stanley-Baker argued, where various types of medicinal practices can coexist and supplement one another.
There needs to be a conversation as to what constitutes robust knowledge in Eastern and Chinese medicine, he concluded. We need to differentiate the Orientalists and the Goop wellness influencers and enthusiasts from serious and respectful practitioners.
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Conspiracy theories fuel French opposition to Covid-19 health pass – FRANCE 24 English
Posted: at 5:18 pm
More than 100,000 people rallied across France on Saturday to protest President Emmanuel Macrons plans torequire a Covid-19 health pass to access public places such as cafs and cinemas starting next week. In addition to traditional concerns about curtailed civil liberties, conspiracy theories have fuelled the opposition to making proof of vaccination obligatory.
Starting July 21, a health pass (pass sanitaire) will be needed to access any of Frances leisure and cultural venues serving more than 50 people, including cinemas and museums. From the beginning of August, the pass will be required on any long-distance public transport, in shopping centres or at cafs and restaurants including on Frances famed outdoor terraces.
The pass must either include the QR code that proves someone has been fully vaccinated in France or results from a negative PCR or antigen test taken in the previous 48 hours.
Frances Covid-19 infection rate has reboundedalarmingly as the more contagious Delta variant has spread, with the average number of new cases confirmed per day soaring to nearly 11,000 from fewer than 2,000 in late June. The uptick prompted Macron to announce the health pass restrictions on July 12.
Too far
Butthe movehas provoked furious opposition among manyin France: some137 rallies took place across the country on Saturday, gathering nearly 114,000 demonstrators(including 18,000 in Paris), according to the interior ministry.
Many appeared to have taken to the streets out of alibertarianbelief that obliging people to be vaccinated if they want to accesspublic venues and activitiesis aninfringementon their basic rights.In no way does a president have the right to decide on my individual health, one Paris protester, who gave her name as Chrystelle, told Reuters.
Lucien, a young shop manager demonstrating in Paris, told AP he was by no means ananti-vaxxerbut that the state should not effectively coerce people to getinoculated.The government is going toofar, he said.
Some mainstream politicians have echoedthese arguments. Franois-Xavier Bellamy, a prominent young MEP for the conservativeLes Rpublicainsparty, and Loc Herv, vice-president of the SenatesCentristesbloc, penned a joint opinion piece in Le Figaro this week in which they laid out their reasons for opposing the measure.
Opposing the health pass does not make someone an anti-vaxxer, they wrote. The essential problem with the pass is that, for the first time in our history, people will have to present a document in order to do the most simple, ordinary things.
Extremes on both sides
But most of the political opposition to the health pass has come from extremes on both sides of the political spectrum. Macrons plans mark a backward step for personal freedoms,said leader of the far-rightNational Rally (Rassemblement Nationalor RN) party,Marine Le Pen,earlier this week. The health pass is an abuse of power,thunderedJean-Luc-Mlenchon, leader of the extreme-leftFrance Unbowed (La France Insoumiseor LFI).
LFI firebrand Franois Ruffin went further on Friday as he urged people to rally, characterisingthe health pass as a means of humiliation coming from an absolute monarchy in the form of Macrons government. Florian Philippot, Le Pens former right-hand man and leader of the right-wing populistLes Patriotesparty,declaredahead of Saturdays protests that they woulddemonstrate the power of the people in the face of a disgrace.
Various populistshave argued against the health pass on civil libertarian grounds, avoiding anti-vax statements. But many of Saturdays protesters thought differently.
Tellingly, when Philippot was addressing the Paris rally and introduced a man called Benjamin onto the stage, saying, Hegot vaccinated, but that was hischoice,there was an awkward moment of hesitation in the crowd,Le Figaro reported. It then erupted into cheers when Philippotsaid, But hes against the health pass! asBenjamin ripped up his vaccination certificate.
Embedded in the crowd, LeFigarosreporterrepeatedly overheardconspiracytheories such as that the pandemic wasorchestrated in advance and its all to make money for the laboratories. When Richard Boutry a former France Tlvisionsjournalist who now tours the country propagatingconspiracy and anti-vax ideas arrived on the scene, many demonstratorschantedhis nickname: Ricardo! Ricardo!
Were members of the Resistance; youve only just go to look at what happened under Vichy one minute different people have different rights, the next a demonstrator told Le Figaros reporter one of several comparisons he heard to the Nazi Occupation.
On Friday night, a vaccination centre in rural southeastern France was broken into and vandalised with the Cross of Lorraine (a symbol of the French Resistance) and graffiti saying Vaccination = genocide and 1940,presumably a reference to the year theVichy regime was founded.
I feel there were likely fewer avowed and strident civilian libertarians than there were conspiracists at these demonstrations, said Andrew Smith, a professor of French politics at the University of Chichester.
French anti-vaxxers likening themselves to the Resistanceconstitutes a worrying manipulation of history,he continued.
It also shows something very specifically French about the anti-vax movement in the country.That language aboutdefeat, collaboration and Nazism its a big difference from what you see in Anglo world, where Nazis are, of course, often the bad guys many people evoke but its much more abstract.
Rise of QAnon
Polling data shows thatFrench anti-vax sentimenthaswanedas thevaccinationrollout proceeded in the first half of the year. Nevertheless, anOpinionWaysurvey published in May found that 20 percent of French adults would turn down a jabwhile13 percent are undecided.
The French Academy of Medicine has said the country needs 90 percent of its adult population to be fully vaccinated toreceive herd immunity and defeatCovid-19.
The popularity ofFrenchpseudo-documentaryHold-Upshows that Covid disinformation has a big audience inthis country.Endorsing anarrayof debunked claims, the online film got more than 2.5 million views after its release in November, with several famous faces including iconic actress Sophie Marceau sharing the video.
It is in this context that the QAnon conspiracist phenomenon which weaves falsehoods about the coronavirus into a broader tapestryof fantasy, including warning of a worldwide cannibalistic cabal of paedophiles hasgrownin France over the past year, boosted byFrench-languagemisinformation websites such as DQodeurs and FranceSoir (a renowned broadsheet in the years after theWorld War II,which closed in 2012 before re-emerging two years ago as a conspiracist Internet publication).
READ MORE:'Stakes are high as QAnon conspiracy phenomenon emerges in France
A boon for Macron?
Nevertheless, conspiracy theories remain a marginal force in French society. Most people in France see that hard work and sensible policies are the route out of the pandemic, not conspiracies, Andrew Smith said.
It seems most Frenchcitizenssee Macrons plan as one such sensible policy: An Ipsos-Storia Sterna poll published on Friday showed that 60 percent of French people favour the health pass and the accompanying plan to oblige all health workersto be vaccinated.
And the pass may well prove to have beena politically expedient move for Macron ahead of the presidentialelectionnext April. When Macron made his announcement on Monday, plenty of people saw it as partly a public health measure but also a campaign message for the presidential elections, observed Paul Smith, a professor of French politics at Nottingham University.
Macrons health passcould beespecially effective at winning over moderate voters who see him charting France a path out of the Covid nightmare and see themselvesas part ofa silent majoritystanding against both the far left and the far right, said Andrew Smith:This policy changes the terrain of the battleground. The traditional right- and left-wing partiesLes Rpublicainsand theParti Socialistewill not and cannot challenge Macron on taking a measured, sensible approach to the pandemic.
You dont win the presidency through 117,000 people spread across the streets of France, Andrew Smith observed.You win through sensible, evidence-based policy to end the pandemic and restart the economy.
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Mechanism of alcoholic osteonecrosis of the femoral head | IJGM – Dove Medical Press
Posted: July 16, 2021 at 1:30 pm
Introduction
Osteonecrosis of the femoral head (ONFH) is a disease in which the local death of osteocytes and bone marrow components is caused by venous congestion or impaired arterial blood supply or the femoral head rupture.1,2 ONFH usually occurs between 30 and 50 years old.1 It is reported that the risk factors of ONFH included corticosteroid use, trauma, alcohol consumption, coagulation abnormalities, hyperlipidemia, and smoking.1 Numerous epidemiological and multicenter studies have shown that most ONFH patients have a history of alcohol abuse. It has been reported that alcohol can destroy bone homeostasis by directly inhibiting the proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs).3 In particularly, alcohol significantly inhibited the proliferation and DNA synthesis of osteoprogenitor cells.4 Therefore, alcohol is a factor that cannot be ignored to cause osteonecrosis of the femoral head.5 At present, there are two main types of osteonecrosis: traumatic and non-traumatic.2 Alcohol-induced ONFH belongs to non-traumatic osteonecrosis.6 Epidemiological studies have reported that 2045% of ONFH patients are associated with alcohol consumption.1 Excessive drinking may lead to dyslipidemia, abnormal differentiation of BMSCs differentiation, and abnormal bone metabolism. In addition, alcohol has a significant dose effect on bone homeostasis.7 However, each individual have different susceptibility, which may be related to genetic predispositions.8 Some studied showed that MMP-8 and MMP-3 gene polymorphisms were related to the risk of alcohol-induced ONFH.9
RAB40C, also known as RARL/RASL8C, is located in 16p13.3. It is a member of the RAS oncogene family and encodes the protein RAB40C. The RAB family of small GTPases was regards as the cellular regulators of vesicular transport,10 and RAB proteins were the key regulators of eukaryotic biofilm transport in all eukaryotes.11 Studies have found that RAB40C was directly regulated by let-7a and played an important regulatory role in the biological role of gastric tumorigenesis.12 Aberrant methylation in RAB40C may be related to the pathogenesis of prostate cancer.13 Our previous work has proved that RAB40C is a novel lipid droplet-related RAB protein,11 which is one of the RAB proteins regulating lipid droplets (LDs) homeostasis.14 Lipid metabolism disorder is considered as the main factor of the pathogenesis of alcohol-induced ONFH.15 Thus, the occurrence of alcohol-induced ONFH may be relevant to RAB40C gene.
In order to verify this hypothesis, this study aimed to search for the association between RAB40C single nucleotide polymorphisms (SNPs) and alcohol-induced ONFH susceptibility, so as to provide guidance for the potential treatment and prevention of the disease.
The ethical approval of this study is in line with the ethical principles of the Helsinki declaration on human medical research. Our study has been approved by the ethics committee of Hong Hui hospital in Xi an, China, and all participants have signed informed consent before participating in the study.
All subjects were the Chinese Han population and included 201 patients and 201 controls. Participants underwent routine physical examinations including internal medicine, surgery, and specialized facial examinations. The diagnostic criteria for alcohol-induced ONFH are based on the clinical manifestations of hip, lumbar, and knee pain and mobility limitations. We further diagnosed the disease by MRI analysis and X-ray examination, such as deformities of the femoral head, hip stenosis, protuberances, or collapsed cartilage fractures.16 The patients were diagnosed with ONFH after using plain radiographs in stage II, III, and IV of the Ficat Classification systems. Stage I is characterized by no radiological abnormalities. Only some joints are stiff and painful, usually with limited joint movement. The symptoms were relieved after rest, and no positive results were found on X-ray films. Occasionally, uniform or spotty osteoporotic areas could be seen. The second stage is characterized by bone reconstruction on X-ray film, with sparse bone and diffuse bone, but no change in the shape of femoral head or joint space. A plain or CT scan of the femoral head shows osteosclerosis, focal osteoporosis, or cystic changes. Stage III is characterized by continuous fracture of subchondral trabeculae with obvious cystic changes and sclerotic margin around it. The femoral head is flattened due to subchondral fracture, mainly in the load-bearing area. Stage IV is characterized by progressive enlargement of subchondral osteonecrosis, further compression and destruction of the femoral head and acetabulum, with narrowing of joint space and typical changes of osteoarthritis.16 The enrolled patients had a history of drinking pure alcohol > 400 mL (320g/week, any alcoholic beverage) per week for six months or more. The inclusion criteria of the control group were as follows: (1) healthy, excluding asymptomatic ONFH (stage I) subjects; (2) age and BMI-matched Han Population in the control group; (3) no recent infection; (4) no other medical history; (5) no history of alcohol abuse.
In 1000 genome project (http://www.internationalgenome.org/), we selected RAB40C candidate SNP sites with allele frequency (MAF) over 5%. Three SNPs (rs4984677, rs62030917 and rs2269556) in RAB40C were finally identified in the case - control study. We isolated the genomic DNA from the whole blood sample using the Goldmag-mini Purification Kit (GoldMag Co. Ltd, Xian, China), and DNA concentration was measured using the NanoDrop 2000 (Thermo Scientific, Waltham, MA). Multiplexed SNP Mass EXTEND assay was designed by Agena MassARRAY Assay Design 4.0 software, and SNP genotyping was performed by Agena MassARRAY RS1000 (Agena, San Diego, CA, USA) according to the standard scheme.17 We also used Agena Typer 4.0 software to analyze and manage our data.18
We used Microsoft Excel (Microsoft, Redmond, WA) and SPSS Statistics (version 17.0, SPSS, Chicago, IL) to analyze the collected data. All the pvalues in the study were two - tailed, and p < 0.05 was statistically significant. The chi-square test was used to evaluate the deviation of Hardy-Weinberg equilibrium (HWE). Pearson Chi - square test or Fishers accurate test were also used to compare the allele frequency and genotype frequency of alcohol-induced ONFH patients with that of the control group. The association between polymorphisms in the RAB40C gene and the risk of alcohol-induced ONFH was calculated on the basis of logistic regression analysis. Four models (co-dominant, dominant, recessive, and log-additive) were established using PLINK version 1.07 software to assess the association between each sites and the alcohol-induced ONFH risk. The pairwise linkage disequilibrium (LD), haplotype construction, and genetic association of polymorphism loci were assessed using the Haploview software package (version 4.2).
This study contained 201 alcohol-induced ONFH patients with an average age of 42.68 12.875 years old and 201 healthy controls with an average age of 42.87 13.270 years old. The independent sample t test showed that no significant difference was between the case group and the control group. In the case group, there were 54 cases in stage I and II, 147 cases in stage III and IV. Moreover, 44 cases with unilateral lesions and 157 cases with bilateral lesions. The information of BMI, alcohol and tobacco use in both cases and controls were shown in the Table 1. Supplementary Table S1 listed the plasma lipoprotein and lipid levels between patients and controls, and the results of the table indicated that there was a significant difference in PLT levels between the two groups.
Table 1 Comparison of Clinical Data in Case and Control Groups
Supplementary Table S2 showed the primers were used for this study. We have successfully genotyped three SNPs of RAB40C gene, and the genotype frequency distribution of all SNPs in the control groups did not deviate from the HWE (p > 0.05). Table 2 showed the basic information of chromosome position, role, MAF (Minor allele frequency) of cases and controls and HWE p-value of the three SNPs located in RAB40C gene. In these three SNPs, the minor allele G of rs62030917 was significantly associated with an increased alcohol-induced ONFH risk (OR = 1.47, 95% CI = 1.072.02, p = 0.017).
Table 2 Basic Information of the Three SNPs in This Study
Then, we used four genetic models (co-dominant, dominant, recessive, and log-additive models) to analyze the relationship between three SNPs and alcohol-induced ONFH risk (Table 3). The result indicated that carriers with G/A-G/G genotype in rs62030917 were more likely to have alcohol-induced ONFH risk compared with AA homozygous carriers (adjusted OR = 1.52, 95% CI=1.022.26, p = 0.039) in the dominant model. In the log-additive model, rs62030917 also increased the risk of alcohol-induced ONFH (adjusted OR = 1.42, 95% CI=1.051.93, p = 0.025).
Table 3 Association Analysis Between SNPs and Alcohol-Induced ONFH Risk
In addition, we also analyzed the association between these loci and the risk of alcoholic osteonecrosis by age stratification and hip lesions stratification (Table 4). Our results suggested that rs62030917 increased the risk of alcohol-induced ONFH among people 42 years old shown in the allele model (OR = 1.62, 95% CI = 1.042.54, p = 0.033), the co-dominant model (OR = 2.99, 95% CI = 1.088.30, p = 0.035), the recessive model (OR = 2.77, 95% CI = 1.037.47, p = 0.044) and the log-additive model (OR = 1.53, 95% CI = 1.002.33, p = 0.048). In patients with unilateral lesions vs controls, rs62030917 conveyed a increasing risk of alcohol-induced ONFH in the allele model (OR = 2.01, 95% CI = 1.233.29, p = 0.005), the co-dominant model (OR = 2.20, 95% CI = 1.084.45, p = 0.036; OR = 3.20, 95% CI = 1.089.48, p = 0.029), the dominant model (OR = 2.37, 95% CI = 1.224.61, p = 0.011) and the log-additive model (OR = 1.90, 95% CI = 1.183.08, p = 0.009). Likewise, rs2269556 also increased the risk of alcohol-induced ONFH (patients with unilateral lesions vs controls) in the allele model (OR = 1.70, 95% CI = 1.072.71, p = 0.023), the co-dominant model (OR = 2.83, 95% CI = 1.137.10, p = 0.027) and the log-additive model (OR = 1.68, 95% CI = 1.062.67, p = 0.028).
Table 4 Correlation Analysis of Rs62030917, Rs2269556 and Alcohol-Induced ONFH After Stratificated by Age and Hip Lesions in Different Genetic Models
Linkage disequilibrium (LD) blocks composed of rs62030917 and rs2269556 were found in unilateral lesions (Figure 1) and older than 42 years old groups (Figure 2), respectively. However, there are no statistically significant correlation between the risk of alcohol-induced ONFH and haplotype. Comparative analysis of plasma lipoprotein and lipid levels (TC, TG, HDL-C, LDL-C and PLT) in carrier with different genotypes of rs4984677, rs62030917 and rs2269556 was shown in Table 5. The results showed that carriers of AA, GA and GG genotypes in rs2269556 had LDL-C levels of 2.55 0.71 mmol/L, 2.78 0.83 mmol/L and 2.95 1.08 mmol/L, respectively, which were significantly different (p = 0.047). Among them, carriers of GG genotype had the highest LDL-C levels.
Table 5 Comparative Analysis of Plasma Lipoprotein and Lipid Levels in Carrier with Different Genotypes of Rs4984677, Rs62030917 and Rs2269556
Figure 1 In patients with unilateral lesions, LD plots containing three SNPs from RAB40C.
Figure 2 In patients older than 42 years old, LD plots containing three SNPs from RAB40C.
The pathogenesis of non-traumatic osteonecrosis is vascular injury, osteocyte death, or defective bone repair.19,20 Long term excessive drinking can lead to dyslipidemia and then induce ONFH.21,22 In recent years, people began to pay attention to the relationship between hereditary susceptibility and alcohol-induced ONFH.2325 Our study on the relationship RAB40C gene polymorphisms and alcohol-induced ONFH is the novel study.
The coding region of RAB40C contains 281 amino acids, which is longer than most small GTPases because it contains a unique SOCS box domain between the conserved GTPase domain and the pre-acylated C-terminal. Special SOCS box domain interacted with the elongated protein B/C and Cul5 modules, and binded with the ring finger proteins to form active ubiquitin ligases, which mediated a series of cellular processes.2628 Our previous work has proved that RAB40C is a novel LDs-related RAB protein.11 This is because there is a unique SOCS box domain of RAB40C, which is necessary for LDs cluster.14 As the proadipocytes differentiate into adipocytes, the expression of RAB40C increased. During the formation and maturation of LDs in adipocytes, RAB40C gradually accumulated to the surface of LDs. RAB40C knockout moderately reduced the size of LDs, suggesting that RAB40C is involved in the biological genetic process of LDs.29
Alcohol induces cell differentiation into adipocytes.30 With the increase of alcohol exposure time and concentration, the number of adipocytes was increased.31 In the alcohol treatment group, intracellular lipid deposition also occurred, which eventually leaded to the death of osteocytes.31,33 These effective findings suggested that alcohol can directly induce adipogenesis, reduce bone marrow mesenchymal osteogenesis, and produce intracellular lipid deposition leading to osteocyte death, which may be related to the occurrence of alcohol-induced ONFH.31 In view of the research, rs62030917 of RAB40C significantly increased the risk of alcohol-induced ONFH. In subjects with unilateral lesions, rs62030917 and rs2269556 increased the alcohol-induced ONFH risk. Rs62030917 increased the risk of alcohol-induced ONFH in people 42 years old.
To sum up, the expression of RAB40C gene increases the risk of alcohol-induced ONFH, which indicates that the gene polymorphisms of RAB40C may increase its risk of disease. There are limitations in the scope and quantity of sample selection in this study. In this study, patients and people from Northwest China were selected, which may be biased. In addition, the sample size of this study is small, and further verification of our results needs larger samples to support. Finally, some polymorphic loci with alcohol-induced ONFH have been screened out at the DNA level, and the relationship between polymorphisms and gene expression level has not yet been evaluated. Therefore, the relationship between polymorphisms and gene expression level needs to be evaluated at the RNA level and protein level. The study only provides a direction for alcohol-induced ONFH research.
Our study indicated that RAB40C gene polymorphism rs62030917 significantly increased the risk of alcohol-induced ONFH and it may be a risk locus. Our study provides a direction for the research on the mechanism of alcoholic osteonecrosis, but it still needs intensive study.
No funds were received in support of this work.
Chang Liu and Xuan Liu are co-first authors for this study. The authors declare that they have no conflicts of interest.
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2. Abu-Shakra M, Buskila D, Shoenfeld Y. Osteonecrosis in patients with SLE. Clin Rev Allergy Immunol. 2003;25(1):1324. doi:10.1385/CRIAI:25:1:13
3. Yu H, Liu P, Zhu D, et al. Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol-induced osteonecrosis of the femoral head. Cell Proliferation. 2020;53(8):e12871.
4. Klein RF, Fausti KA, Carlos AS, Ng EL, Tang BL. Ethanol inhibits human osteoblastic cell proliferation. Alcohol Clin Exp Res. 1996;20(3):572578. doi:10.1111/j.1530-0277.1996.tb01095.x
5. Guo YJ, Luo SH, Tang MJ, et al. Muscone exerts protective roles on alcohol-induced osteonecrosis of the femoral head. Biomed Pharmacother. 2018;97:825832. doi:10.1016/j.biopha.2017.11.025
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13. Geybels MS, Alumkal JJ, Luedeke M, et al. Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors. Clin Epigenetics. 2015;7:128. doi:10.1186/s13148-015-0161-6
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Mechanism of alcoholic osteonecrosis of the femoral head | IJGM - Dove Medical Press
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