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Monthly Archives: February 2021
Zombies Attack Bend! [With Video] – The Source Weekly
Posted: February 12, 2021 at 5:28 am
Within seconds of entering the game, a zombie takes me out. Not being someone who regularly indulges in video games and having only put on an Oculus virtual reality headset once, I guess I'm red meat for the zombies who now surround me in this virtual reality arena. Fortunately for me, the game master gets on the headset, reminding me that I have a "gun" in my hand and that I can use it to shoot the zombies, now swarming. I get in a good scream, run forward and manage to take out a zombie or two.
It's my first time at Zero Latency, the virtual reality arena that recently opened on Third Street in Bend. I'm terrible at first, but over the course of the first 15-minute game in the arena, I get better at knowing where the zombiesmy height and making creepy noises all the whileare coming from. I mostly manage to take them out before they overcome me, but the game is sometimes so real that my genuine fear has my brain going haywire, paralyzed. When the game ends and I and my teammatesSource Publisher Aaron Switzer and his son, Sean, our distribution managertake off our headsets, I'm informed that I am what's known as "a screamer." Apparently, the game was real enough that I was erupting in little screams the whole time.
The younger Switzer, far more of a gamer than I, tells me that this was far cooler than playing with a VR headsetthe more DIY and sedentary version of what we are now experiencing in its fullest form. Zero Latency, a company that started in Melbourne, Australia, in 2014 and is quickly opening franchises around the world, offers a fuller experience than that headset, with a "free roam virtual reality experience." Bend's location is one of 15 located in the U.S.
WATCH: The Source sent videographer Darris Hurst to go check out the action at Zero Latency.
"The best part about these games has got to be the people," said Zero Latency Bend's co-founder Terry Walkey. "They're excited. They come out of there with their minds blown, and that's just such a great feeling."
Zero Latency Bend, opened by Walkey, his wife and another partner, just opened this month, following Gov. Kate Brown's relaxation of rules for counties still in the Extreme Risk category, which allows for up to six patrons inside gyms and indoor recreation facilities. The arena's owners had hoped to open in October, but COVID-19 restrictions prohibited that until now.
Now, up to six players can play together in each session, taking on zombies in one of two games, including Undead Arena and Zombie Survival. When restrictions relax even more, more games, including Sol Raiders, Outbreak Origins, Engineerium and Singularity (not all zombie and shoot-em-up related)which allow for less social distancingwill also come online. Under normal circumstances, up to eight people can play together. Another popular game, Far Cry, is also coming soon.
Players register on the Zero Latency site, and right now, ZL is offering a one-time 25% off price through March 3. (Just enter the code FEB25 to get the discount.) On Sundays, a 30-minute session that includes suiting up and game master instruction costs $26, or get 60 minutes for $52. Regular 45-minute sessions cost $45. Outside the arena are areas for gathering, having a beverage or a private party.
Zero Latency Bend1900 NE 3rd. St., Suite 104, Bendzerolatencybend.com
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Virtual reality and naturalistic developmental behavioral interventions for children with autism spectrum disorder. – Physician’s Weekly
Posted: at 5:28 am
Naturalistic Developmental Behavioral Interventions (NDBI) have been evaluated as the most promising interventions for children with autism spectrum disorder. In recent years, a growing body of literature suggests that technological advancements such as Virtual Reality (VR) are promising intervention tools. However, to the best of our knowledge no studies have combined evidence-based practice with such tools.This article aims to review the current literature combining NDBI and VR, and provide suggestions on merging NDBI-approaches with VR.This article is divided into two parts, where we first conduct a review mapping the research applying NDBI-approaches in VR. In the second part we argue how to apply the common features of NDBI into VR-technology.Our findings show that no VR-studies explicitly rely on NDBI-approaches, but some utilize elements in their interventions that are considered to be common features to NDBI.As the results show, to date, no VR-based studies have utilized NDBI in their intervention. We therefore, in the second part of this article, suggests ways to merge VR and NDBI and introduce the term Virtual Naturalistic Developmental Behavioral Interventions (VNDBI). VNDBI is an innovative way of implementing NDBI which will contribute in making interventions more accessible in central as well as remote locations, while reducing unwanted variation between service sites. VNDBI will advance the possibilities of individually tailoring and widen the area of interventions. In addition, VNDBI can provide the field with new knowledge on effective components enhancing the accuracy in the intervention packages and thus move forward the research field and clinical practice.
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Augmented Reality & Virtual Reality Marketfor Retail Industry by Global Business Opportunity, Development, Growth Factors, Applications Analysis…
Posted: at 5:28 am
Data Bridge Market Research has recently published the Global research Report TitledAugmented Reality & Virtual Reality Marketfor Retail Industry.The study provides an overview of current statistics and future predictions of the Augmented Reality & Virtual Reality Marketfor Retail Industry. The study highlights a detailed assessment of the Market and displays market sizing trends by revenue & volume (if applicable), current growth factors, expert opinions, facts, and industry validated market development data.
A variety of financial terms such as shares, cost, revenue, and profit margin have been included in this Augmented Reality & Virtual Reality Marketfor Retail Industry document to get a better understanding of different economic aspects of the businesses. This industry analysis report presents an actionable vision to key participants working on it. The report observes numerous in-depth, influential and inducing factors that outline the market and industry. Augmented Reality & Virtual Reality Marketfor Retail Industry report states that the global market is anticipated to expand significantly and is projected to reach million USD$ by 2027, at a CAGR during the forecast period. The report has been prepared by using primary and secondary research methodologies.
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Global Augmented Reality & Virtual Reality Marketfor Retail Industry Analysis: Augmented reality & virtual reality market for retail industry is expected to reach USD 2,094.08 billion by 2027 witnessing market growth at a rate of 68.5% in the forecast period of 2020 to 2027. Data Bridge Market Research report on augmented reality & virtual reality market for retail industry provides analysis and insights regarding the various factors expected to be prevalent throughout the forecast period while providing their impacts on the markets growth.
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Chapter 1: Introduction, market driving force product Objective of Study and Research Scope Augmented Reality & Virtual Reality Marketfor Retail Industry
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Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges of Geotextile Tube
Chapter 4: Presenting Augmented Reality & Virtual Reality Marketfor Retail Industry Factor Analysis Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.
Chapter 5: Displaying the by Type, End User and Region
Chapter 6: Evaluating the leading manufacturers of Augmented Reality & Virtual Reality Marketfor Retail Industry which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile
Chapter 7: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions.
Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source
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Virtual Reality Can Assist People Suffering from Executive Function Impairments. Here’s How – News18
Posted: at 5:28 am
A team of US researchers has utilised Virtual Reality (VR) to effectively test a participant's executive functional load, or how much information a person can process to achieve a goal in a real-world setting.
By using VR technology to examine how folks complete daily tasks, like making a grocery list, researchers can better help clinical populations that struggle with executive functioning to manage their everyday lives.
The researchers hope to use their VR assessment to help people that suffer from executive function impairments.
"We used VR technology to create an executive function assessment that can be used in neuropsychology to understand how veterans and other clinical populations manage their everyday lives," said lead author Zhengsi Chang from Center for BrainHealth, part of The University of Texas at Dallas' school of Behavioral and Brain Sciences.
The researchers adapted the Virtual Reality Functional Capacity Assessment Tool's (VRFCAT) "kitchen test", where participants plan a trip to the grocery store by comparing ingredients in kitchen cabinets to a list of recipes.
"Function-led tasks using VR technology allow us to maintain a balance between ecological validity and experimental control," Chang said in a journal Computers in Human Behavior Reports.
In the virtual kitchen, 42 healthy adult participants memorised a slew of ingredients from a recipe list.
Once they finished checking their grocery list, participants picked up their wallet and left the virtual kitchen.
To test their executive functional load, the researchers increased the number of ingredients and recipes to be memorised.
Participants took longer to complete their grocery lists when they had to memorise more ingredients.
This aligned with the researchers' prediction that participants' task performance would decrease as functional load increases, which suggests that this VR assessment can effectively test executive functional load.
Upon further analysis, the researchers realised that participants were actually switching up their strategies as executive functional load increased.
"Some participants tried to memorise as many ingredients as possible before looking at the recipe while others frequently switched between rummaging through the kitchen cabinets and examining the recipe list," the findings showed.
"This study indicates that our strategies have a dramatic effect on our capacity. If you enter into a task prepared with a plan, you will get the most out of your brain and see much better performance," said Daniel Krawczyk, deputy director of the Center for BrainHealth.
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Virtual Reality Can Assist People Suffering from Executive Function Impairments. Here's How - News18
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US Attorney who prosecuted Antifa suspects will resign at request of Biden admin – Fox News
Posted: at 5:26 am
Oregon U.S. Attorney Billy Williams, a Trump-appointee who prosecuted more Antifa suspects than any other, is among many federal prosecutors who will resign from their positions at the behest of the Biden administration.
Williams, 64, was officially appointed to the job by former President Donald Trump in 2017 after holding it in an acting and interim capacity since 2015, when he replaced former U.S. Attorney Amanda Marshall, who resigned during a sexual harassment investigation.
Last week, he reported that Portlands summer of rioting had caused at least $2.3 million to a handful of federal buildings in the city alone.
Billy Williams the United States Attorney for the District of Oregon speaks during a press conference January 27, 2016 at the Harney County Chamber of Commercein Burns, Oregon. (ROB KERR/AFP via Getty Images) (Getty Images)
PORTLAND RIOTS CAUSED AT LEAST $2.3M IN DAMAGE TO FEDERAL BUILDINGS, US ATTORNEY SAYS
Williams office had filed the most domestic terrorism cases out of any U.S. attorneys office in the country in 2020, the Oregonian reported. Most of them were in connection with more than two months of protests outside the citys Mark O. Hatfield U.S. Courthouse.
The nightly standoffs with police involved graffiti, broken windows and firecrackers, as well as Molotov cocktails.
Although the riots stemmed out of protests against the Trump administration, police brutality and racial injustice, they continued even after President Biden took office on Jan. 20. Antifa marchers blasted the new president and new anti-Biden graffiti emerged.
Other recent cases led by his office included the prosecution of a man who sent threatening cards and white powder to former co-workers and a fraud case against a former Nike marketing manager.
Hes not the only Trump-appointed federal prosecutor that the Biden administration has asked to step down, although a bipartisan group of senators had initially supported Williams for the job.
The Justice Department on Tuesday asked most U.S. attorneys appointed by Trump to resign although the prosecutor overseeing a federal tax probe involving the presidents son, Hunter Biden, will remain on the job at the request of acting Attorney General Monty Wilkinson.
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U.S. Attorney John Durham, who former Attorney General Bill Barr appointed to investigate the Trump-Russia probe in October, will also stay on in that capacity while being asked to step down from his role as U.S. attorney in Connecticut.
Historically, its not unusual for federal prosecutors to leave their positions when a new president takes office.
The Associated Press contributed to this report.
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US Attorney who prosecuted Antifa suspects will resign at request of Biden admin - Fox News
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Antifa uses Twitter to threaten me and the media: Seattle radio host – Yahoo News
Posted: at 5:26 am
Axios
New conspiracy charges have been filed against five people associated with the Proud Boys, a far-right extremist group, over their alleged involvement in the deadly Jan. 6 Capitol siege, according to the Justice Department. Why it matters: The arrests are the latest move against the Proud Boys, who have a history of violence. Authorities have focused their attention on the group as they investigate the Jan. 6 storming of the U.S. Capitol by supporters of former President Trump.Get market news worthy of your time with Axios Markets. Subscribe for free.More than a dozen people affiliated with the group have already been charged in connection to the Capitol riots, per the Washington Post.Details: William Chrestman, Christopher Kuehne, Louis Enrique Colon, Felicia Konold and Cory Konold have been charged with conspiracy, civil disorder, obstruction of an official proceeding, among other charges, according to criminal complaints unsealed Thursday after the individuals were taken into custody. Kuehne, Colon and the Konolds have been charged in joint conspiracy filing, while Chrestman was charged in a separate filing. According an FBI affidavit, the five individuals were repeatedly observed with the Proud Boys group who were seen outside, and later inside the Capitol on Jan. 6. The SUBJECTS not only moved closely to each other in proximity, but also appeared to gesture and communicate to one another both before and while inside the Capitol in an apparent effort to coordinate their efforts, an FBI agent said in the affidavit. Most wore tactical-style gear, including helmets and gloves, and Chrestman carried a wooden club or axe handle disguised as a flag, according to the FBI agent. "Your affiant believes that there may be more persons involved in this particular conspiracy than the persons described throughout this affidavit, and the investigation is ongoing," a footnote in the affidavit noted. The big picture: During Trump's impeachment trial this week, House managers have pointed to the Proud Boys' involvement in the Capitol riot.The managers have also tied the Proud Boys to Trump, who refused to condemn the extremist group during the 2020 campaign.More from Axios: Sign up to get the latest market trends with Axios Markets. Subscribe for free
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Antifa uses Twitter to threaten me and the media: Seattle radio host - Yahoo News
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Ted Cruz blasts hypocrite Dems for cheering on BLM and Antifa while accusing Trump of inciting riot – The Sun
Posted: at 5:26 am
REPUBLICAN Ted Cruz has blasted the "hypocrite" Democrats for "cheering on" Black Lives Matter and Antifa while accusing former president Donald Trump of inciting a riot.
Cruz, the Texas Senator since 2013, revealed his thoughts just hours after theSenate voted 56-44to continue with the former president's second impeachment trial and Trump's defense attorney's were criticized.
* Read our Donald Trump impeachment live blog for the very latest news and updates on the former president...
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Speaking with Fox news host Sean Hannity on Tuesday night, Cruz admitted Trump's language could be "a little over heated" at times.
However, he explained: "If you look at the language he used, saying things like 'fight' - saying things like 'go retake our country' - if that is now incitement then we better prepare a long line to indict every candidate for office, anyone who's ever run."
Cruz slammed anyone who takes part in violence, regardless of them being Republican or Democrats, engaging in "unacceptable behavior."
He told Hannity: "The Democrats have been complete hypocrites on this, cheering on BLM and Antifa and apologizing for their violence.
"We have had Democrats for a year, cheering on. We have seen violence all of the country. We've seen riots all over the country.
"What do the Democrats do, they cheered it on - They celebrated."
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Cruz recalled the Democrats' "hatred" for Trump and shared a clip of his interview to Twitter.
He captioned the Twitter post: "Democrats want a week of political theater raging at Donald Trump instead of focusing on reopening schools or getting millions of Americans back to work."
Cruz said he believed Trump's Tuesday impeachment hearing "typified what we're going to see this week."
At another point during his talk with Hannity, Cruz pointed out that Vice President Kamala Harris "raised money to pay for the bail" of Minnesota demonstrators.
He slammed her for bailing out "violent criminals."
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The 50-year-old politician also published an Op-Ed in Fox News, headlined: "Should the Senate exercise jurisdiction over Trump's impeachment trial? Why the answer matters."
Cruz backed up his reasoning behind voting to "dismiss this impeachment on jurisdictional grounds."
"And nothing in the Constitution makes the Senates impeachment jurisdictionmandatory. 'Sole power' means 'sole power' - the Senate can decide whether to hear the case," Cruz said.
"The present impeachment is an exercise of partisan retribution, not a legitimate exercise of constitutional authority."
Meanwhile, Senators will move forward with the second day of Trump's impeachment hearings on Wednesday, February 10.
TEEN TRAGEDY'Kind and loving' schoolboy, 15, dies after being found unconscious at park
POWYS TO THE PEOPLEBrits could holiday in Wales at EASTER with pubs and restaurants open
POSTMAN PRATPostie left OAP, 72, in the snow after she fell because he was 'too knackered'
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ALLY ROSSLoud and a giant pain... no, not just Gemma Collins, Piers Morgan too
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MODEL 'MURDER'First pic of man, 24, charged with murder after model found dead in river
Last month, the Texas GOP senator suggested that former presidents Jimmy Carter, Bill Clinton and Barack Obama could be impeached next as he blasted the "unconstitutional" Trump trial.
Cruz slammed the partisan, divisive, angry impeachment trial of Trump and told Hannity the Democrats' perceived urgency in impeaching Trump was an "exercise in political rage."
"This is not driven by the needs of the country, this is not driven by trying to help out the people who are hurting back home," Cruz said. "This is driven by partisan rage and the partisan anger they feel. This was an exercise in political ragethey hate Donald Trump."
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Australian Proud Boys on the hunt for social media commenters and the elderly – Independent Australia
Posted: at 5:26 am
A division of the Proud Boys in Albury has resorted to harassing social media commenters and elderly residents who they don't agree with, writes Tom Tanuki.
THIS TALE ends with a group of MMA fighters hunting an elderly Albury man. Bear with me.
So, theres a small Albury chapter of the far-right group known as the Proud Boys. Its led by one Jarrad Searby. Jarrad runs a gym called Hard Knocks Combat. He became briefly famous in July for refusing to apply for a border permit, telling cops that COVID-19 is fake and getting arrested. After that, he tried to join the ranks of anti-lockdown grifters by asking for half a million dollars for whatever. (He got only $50.)
Eventually, he was groomed by the Proud Boys, who want to look tough as much as Jarrad wants to feel important. So now theres a Proud Boys chapter in Albury. The Corowa RSL lets them train in their space.
A left-wing Facebook page called Anti-Fascist Action Albury noticed Jarrad, posting about him and his local business activity. They noted their concern about the involvement of the Corowa RSL in Proud Boys activity. Im informed it was all public information, mostly posted by Jarrad to his Telegram social media channel.
One man commented: They never send their best.
Heres a picture of that comment:
But its not like a random comment from a random person matters, does it? Still, remember that for later.
I understand if local Proud Boys are worried about being in the spotlight like this. Theres been talk from Labor about designating the Australian Proud Boys as a terrorist organisation in the wake of recent developments in Canada.
Through the constant street fighting between U.S. far-right extremists and anti-fascists, the Proud Boys made their name by bashing people on camera at rallies. The threat of criminal designation has hung over the group since 2018 when the FBI was rumoured to be considering declaring them a gang. After all that, the prominent role Proud Boys played in the recent attempted U.S. Capitol insurrection was too much for the Canadian Government, who declared them a terrorist organisation.
Hard to imagine that anything similar would happen here, though. Our Liberal Government is more interested in taking the term far-right out of motions condemning extremism. Australian Proud Boys all mainline U.S. culture wars, suffering from same nationality dysphoria as most Australian far-right types (read: they all reckon theyre Yanks). But to date, theyve mostly just LARPed as Americans and fixated on a handful of online leftists to pass the time.
The group is smaller in Australia and has been less directly confrontational at rallies so far. Still, they realise theyre in the spotlight now and theyve made a few statements about that on their page, insisting theyre a peaceful group. They dont want to risk further trouble so they are being careful.
I mean, they were being careful. Then Jarrad had a great idea.
Remember Jack, the random bloke with the they never send their best comment? They found Jacks employer on his Facebook profile.
They sent Jacks bosses this message:
You may ask yourself: is a comment saying they never send their best an attempt to destroy the lives of his neighbours? Is that Facebook comment a liability to any HR department? Probably not.
But it didnt end there. The next day, they visited Jacks workplace.
The video, re-uploaded by Anti-Fascist Action Albury, features Jarrad and two other Proud Boys harassing staff at the business. They barge into the staff office and demand Jack is fired. Jarrad tells them Jack has been doxxing our businesses and is a member of the anti-fascist movement. Its surreal viewing. They tell staff that theyll begin protesting out front unless Jack is fired.
Heres Jarrad standing in their office holding a photo of Jacks extremist Facebook comment:
Jarrad later released a video saying hed visited Jacks workplace because he had been doxxed by Antifa. Then he explained that he makes all his business and info public so he cant be doxxed. Jarrad, if doxxing is the release of private or sensitive information and you made all this information public, doesnt that mean you werent doxxed, mate?
Never mind. Theyre not sending their best here.
I want to make this clear, as an anti-fascist who is part of a network of anti-fascists: Ive asked around. Ive asked everybody. Asked the Albury page. Nobody knows who Jack is.
Hes not a member of any anti-fascist movement. Hes a guy. Named Jack. From Albury. With a Facebook account. Who doesnt like Proud Boys.
Apparently, thats hardline anti-fascism now. Apparently, thats a sackable offence now. Apparently, thats grounds for Jarrad and his MMA mates to start stalking you, threatening your boss and demanding you be fired.
While I appreciated Jacks comment, on reflection I think he was wrong. I reckon they are sending their best. Jarrad is the kind of loser they all aspire to be in the Australian Proud Boys. And because stalking employers is never enough for these dregs once they get a taste of some likes (the workplace harassment video is popular on TikTok), Jarrads escalating.
How do I know hes escalating? Well, for one, during a time when Proud Boys should tread lightly, hes off harassing random Facebook users for not liking him. For another, only two days after he harassed Jacks employer, Jarrad uploaded a video to his YouTube channel called Antifa hunters vol.2 at the home on 10 February.
In it, he visits a house of someone he says is Antifa. He is calling out for an Alastair, walking down the side of the house, peering in, banging on the door. For reasons unknown, Jarrad has since removed the video from his channel.
Whos Alastair? I had no idea. But by now we know that Jarrad thinks Antifa is just Facebook commenters, so I checked the old post the same one where Jack commented.
I found Alastair.
Turns out Alastair is an elderly man.
(Dont worry, hes fine. Hes gone to the police.)
So now Antifa includes retirees. Amazing! What will Jarrad Searby do next? Go Antifa hunting in an aged care facility? A hospice? Be glad if you dont live in Albury to find out.
The important thing to know is that the final tier of Proud Boys initiation the fourth degree is to get into a fight with Antifa. They consider it a badge of honour. But now that Antifa is anyone Jarrad Searby says it is, including old men and random locals who dont love him online, whatll he do next? Can you picture Jarrad Searby fly-kicking pensioners for his fourth degree?
I assume Jarrad is recruiting young men to his local Proud Boys chapter at Hard Knocks Combat. The one in Corowa RSL.
The Albury community has a right to be worried. If they werent worried before, they will be when they find out that Jarrads stalking the elderly for the crime of commenting about him. Its not my place to say whether thats terrorist activity, but its rank intimidation and I would hate to see it in my town.
Tom Tanukiis an online satirist, social justice commentator, writer and comedian. He has worked in anti-racist political comedy, most notably through his satirical group the Million Flag Patriots and anti-racist groupYelling At Racist Dogs(Y.A.R.D.). You can follow Tom on Twitter@tom_tanuki.
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What Makes You Think Its Over? – The American Prospect
Posted: at 5:26 am
The Democratic House managers began the third and final day of laying out their case by establishing what prosecutors call the accuseds pattern and practice. By this, they meant that Donald Trump had repeatedly both commended and recommended violence by his supporters and refused to condemn it when it happened. They showed clips from his rallies where he urged the crowd to beat his critics, from his good people on both sides comments following Charlottesville, and from his mockery of the threat posed to Michigan Gov. Gretchen Whitmer by those plotting to kidnap her.
Whether or not they succeeded in convincing Republican senators that they should convict Trump, the managers certainly made a compelling case to the American electorate, should Trump be free to run again, of how the next Trump campaign, much less a second Trump presidency, would likely come complete with even more violence than hes provoked so far. They bolstered this claim by showing how violent extremists view Trump as their leader, a belief that Trumps instilled by his post-Charlottesville remarks and his stand back and stand by endorsement of the Proud Boys.
More from Harold Meyerson
On their third day before the Senate, the prosecutors turned to the futureto the consequences that allowing a president who violated his oath to defend the Constitution to escape without conviction would have for the future of American democracy and its peaceful transfers of power. If Trump is acquitted and violence and insurrection go unpunished, said lead manager Jamie Raskin, what makes you think its over?
Cumulatively, the managers was a masterful, overwhelming case. They spent the final hour in prebuttals of Trumps lawyers coming defense. Incitement of insurrection couldnt be defended as free speech, they argued. The constitutionality of trying a former president, they noted, had already been decided; with the law no longer in question, senators now had to vote on the facts in the case.
Whether Republicans actually do vote on the facts in the case remains highly uncertain at best, of course. Those whove actually paid attentionand we dont know how many havewill surely believe that conviction is the proper remedy, not just for Donald Trump, but to ensure the future of American democracy. Thats not to say, however, that even if theyve been convinced of Trumps guilt, theyll vote that way.
Thats largely because they cant help noting that their political future will be shaped by the rapid descent in the character of their party, which is becoming more delusional by the day. Even as The New York Times has reported that increasing numbers of Republicansdisproportionately, I dont doubt, those who still dwell in the reality-based communityhave left the party since January 6th, the senators also know that Republican state and county committees are casting maledictions on Republican elected officials whose loyalty to Trump is suspect. Perhaps even more disquieting, a poll conducted for the American Enterprise Institute shows that 50 percent of Republicans believe that antifa was mostly responsible for the violence that happened in the riots at the US Capitoldespite the fact that all the videos, all the arrests, all the coverage of the insurrectionists make clear that the rioters were right-wing nutsmuch like the people now insisting that they were really antifa.
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What all this means is that Republican senators are pondering their future in a party from which the sane are fleeing and the delusional remain. Those whose career ambitions overcome their deep sense that Trumps conviction is not only justified but also necessary for the future of the republic may have trouble with their decisions in what Scott Fitzgerald termed the real dark night of the soul. I dont think their souls will resist all that strongly, however. Theyll likely get through it by telling themselves something like what The Maltese Falcons Sam Spade tells the femme fatale hes fallen for when he turns her over to the cops for a murder she committed.
Ill have some rotten nights, he says, but thatll pass.
February 11, 2021
6:42 PM
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Precision Medicine Platform Aims to Advance Cancer Gene Therapies – HealthITAnalytics.com
Posted: at 5:25 am
February 11, 2021 -A team from Cleveland Clinic has developed a precision medicine platform designed to accelerate cancer gene therapies and genome-informed drug discovery.
In a study published in Nature Genetics, researchers describe the My Personal Mutanome (MPM) platform. The platform features an interactive database that offers insight into the role of somatic mutations in cancer acquired mutations that cant be passed to offspring and prioritizes mutations that may be responsive to drug therapy.
Although advances in sequencing technology have bestowed a wealth of cancer genomic data, the capabilities to bridge the translational gap between large-scale genomic studies and clinical decision making were lacking, said Feixiong Cheng, PhD, assistant staff in theGenomic Medicine Institute, and the studys lead author.
MPM is a powerful tool that will aid in the identification of novel functional mutations/genes, drug targets and biomarkers for cancer, thus accelerating the progress towards cancer precision medicine.
The team used clinical data to integrate nearly 500,000 mutations from over 10,800 tumor exomes the protein-coding part of the genome across 33 cancer types into the platform. The team then systematically mapped the mutations to over 94,500 protein-protein interactions (PPIs) and over 311,000 functional protein sites where proteins physically bind with one another. Researchers then incorporated patient survival and drug response data.
The platform analyzes the relationships between genetic mutations, proteins, PPIs, protein functional sites, and drugs to help users easily search for clinically actionable mutations. The MPM database includes three interactive visualization tools that offer two- and three-dimensional views of somatic mutations and their associated survival and drug responses.
According to the researchers, previous studies have linked disease pathogenesis and progression to mutations and variations that disturb the human interactome, the complex network of proteins and PPIs that impact cellular function. Mutations can disrupt the network by directly changing the normal function of a protein, known as nodetic effect, or by altering PPIs, known as edgetic effect.
Additionally, in a separate, previous study, a team of researchers found that somatic mutations were highly enriched where PPIs occurred. The group also demonstrated that PPI-perturbing mutations were significantly correlated with drug sensitivity or resistance as well as poor survival rate in cancer patients.
The results from another study published inNature Genetics, which was a collaboration between Cleveland Clinic and several other institutions, motivated us to develop the mutanome platform, said Cheng.
OurNature Geneticsfindings, along with previous research, provide proof-of-concept of both nodetic and edgetic effects of somatic mutations in cancer. What we learned from that study inspired us to develop a systems biology tool that, by mapping mutations to PPI interfaces and protein functional sites and integrating survival and drug response data, identifies cancer-driving and actionable mutations to guide personalized treatment and drug discovery.
Researchers expect that MPM will lead to a better understanding of mutations at the human interactome network level. This could lead to new insights in cancer genomics and treatments, ultimately achieving the goal of cancer precision medicine.
The team will continue to update MPM annually in order to provide researchers and physicians with the most comprehensive, complete data available. Researchers also plan to apply advanced analytics technologies to their insights to improve treatment development for other conditions.
OurNature Geneticsstudy also demonstrates the nodetic and edgetic effects of mutations/variations in other diseases, said Cheng.
As a next step, we are developing new artificial intelligence algorithms to translate these genomic medicine findings into human genome-informed drug target identification and precision medicine drug discovery (i.e., protein-protein inhibitors) for other complex diseases, including heart disease and Alzheimers disease.
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Precision Medicine Platform Aims to Advance Cancer Gene Therapies - HealthITAnalytics.com
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