Daily Archives: August 26, 2020

Democrats: Trump Is Blocking Post Office Funding – MyMotherLode.com

Posted: August 26, 2020 at 3:56 pm

Rail Road Flat Post Office Photo by Michael Lance Miller

During the Democratic Weekly Address, House Oversight Committee Chair Carolyn Maloney (D-NY) stated that President Trump is blocking $25 billion in Post Office funding to hinder mail-in voting.

Maloney was Tuesdays KVML Newsmaker of the Day. Here are her words:

Hello, Im Congresswoman Carolyn Maloney. I have the privilege of representing parts of Manhattan, Brooklyn and Queens in New York City. I also serve as the Chairwoman of the Committee on Oversight and Reform in the House of Representatives.

Today, I would like to talk to you about one of our most enduring and beloved institutions the United States Postal Service one of the few entities specifically mentioned by our Founders in the Constitution.

The Postal Service delivers more than 470 million pieces of mail each day to every home and business across the United States. It provides a critical lifeline by providing universal access to medications, supplies and mail for every single American, no matter where you live.

Today, I will not mince words. The Postal Service is under attack. In newspapers from every corner of the country, we have seen the stories and pictures. Mail is being delayed by days and sometimes even weeks. Sorting equipment is being ripped out of postal facilities and thrown into dumpsters; and mailboxes are being removed from street corners; and overtime is being denied for our postal carriers, who are some of our most essential workers during the coronavirus crisis.

This didnt happen by accident. It was intentional. This happened because President Trump has been blocking critical funding for the Postal Services now for months and now his hand-picked Postmaster General is using this fact to justify sweeping and damaging changes that are degrading postal operations before our very eyes.

Last week, President Trump admitted on national television that he has been blocking $25 billion in critical assistance, assistance that was requested by the Postal Service, because he wants to hobble mail-in voting.

Now, think about that for a minute. That is about the most undemocratic action I can think of.

Whats worse, instead of supporting funding to strengthen an institution that is vital to every American, the Trump Administration is going in the opposite direction and dismantling long-standing policies and procedures, with disastrous consequences. We cannot and will not stand by and let that happen.

This past Tuesday, as part of our Day of Action to Save the Post Office, more than 100 House Democrats hosted events in our districts to support the Postal Service, its mission and postal workers.

We have requested a host of documents from the Postmaster General, which are due this week, and we have called him to testify before our Committee on Monday morning.

In addition, on this Saturday, the House will reconvene for a special session to vote on my bill, the Delivering for America Act. This legislation will do two important things. First, it will provide the $25 billion the Postal Service requested, which was supported unanimously by the Postal Service Board of Governors, all of whom were appointed by President Trump. And it will return delivery standards to the way they were before the Postmaster Generals sweeping changes.

We want the Postmaster General to undo the damage he has already done, put back the sorting machines and mailboxes he has already removed and prioritize official election mail as First-Class mail, as it previously was.

Every Member of Congress should support this bill. This is not a partisan issue. Republicans across the country have expressed their own serious concerns about these delays and the Presidents statements. It makes absolutely no sense to impose these kinds of dangerous cuts in the middle of a pandemic and just months before the elections in November.

What is happening right now is impacting everyonein rural and urban communities, among seniors, veterans, small businesses and families across the country. I believe the American people want their mail left alone. They want to go back to the way things were before all these changes began. And they certainly do not want the Postal Service to be politicized. Our legislation achieves all of the goals. I hope the American people will continue letting their Representatives know how they feel.

Thank you for listening. Thank you.

The Newsmaker of the Day is heard every weekday morning at 6:45, 7:45 and 8:45 on AM 1450 and FM 102.7 KVML.

Written by Mark Truppner.

Report breaking news, traffic or weather to our News Hotline 532-6397. Send Mother Lode News Story photos tonews@clarkebroadcasting.com. Sign up for our FREE myMotherLode.com Daily Newsletters by clicking here.

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Spurred by calls for reform, Palo Alto backs restrictions on police use of force – Palo Alto Online

Posted: at 3:56 pm

With the shooting of Jacob Blake in Wisconsin spurring a fresh wave of protests against police brutality, the Palo Alto City Council agreed on Monday to revise the Police Department's policies on use of force and vowed to pursue broader initiatives to promote racial justice.

By a unanimous vote, the council endorsed a set of revisions to police policies that largely comported to recent recommendations from the city's Human Relations Commission. The goal was to better align the city's official policies with those in the 8 Can't Wait platform, a project of Campaign Zero, a nonprofit that focuses on reducing police violence.

The campaign calls for a ban on chokeholds and requirements that officers prioritize de-escalation, provide warnings before shooting, exhaust all alternatives before shooting, intervene when they see excessive force, avoid shooting at moving vehicles, follow a use-of-force continuum and report all incidents of force.

In debating the changes to police policies, the council at times struggled to reconcile the recommendations of the Human Relations Commission, which supported broader restrictions on use of force, and those of department leadership, who urged the council not to adopt any policies that would hinder officers' ability to protect themselves during dangerous situations.

The Rev. Kaloma Smith, who chairs the commission, observed that the conversation feels particularly urgent in the aftermath of the shooting of Blake, which sparked protests in Kenosha, Wisconsin on Sunday and Monday. A video of the incident showed a police officer shooting Blake seven times at close range as he was entering his vehicle.

Blake was in stable condition in an intensive care unit on Monday night, according to multiple news reports.

"This moment was sparked by the killing of George Floyd and last night we watched Jacob Blake get shot in the back seven times by officers," Smith said. "This makes this conversation more of a priority right now, because we don't want to end up in this position."

The Police Department has already adopted some new restrictions, moving in June to ban the carotid hold and agreeing to make the existing ban on chokeholds and strangleholds more explicit in its policy manual. Police Chief Robert Jonsen and Assistant Chief Andrew Binder also agreed with the Human Relations Commission that they should expand the department's de-escalation policy to list the types of techniques that officers should use to avoid violence, including effective communication, self-control and requesting additional resources such as crisis intervention team members to decrease the need to use force.

The council agreed that the policy on strangleholds should go even further and supported the Human Relations Commission's proposed change, which also bans "lateral vascular neck restraints, chest compressions" and other moves that restrict airflow.

"What everybody agrees on is that what happened to George Floyd or Eric Garner can't be allowed to happen in Palo Alto," said Councilman Eric Filseth in discussing the proposed change.

While Smith similarly argued that the city needs to send a clear message that the types of moves that resulted in the deaths of Floyd and Garner (who was killed by a New York City officer in 2014) should be banned, Jonsen and Binder countered that the proposed restrictions are too broad. Jonsen suggested that implementing policies that outright ban certain actions "could have a detrimental effect, not only to officers' safety but to the public at large." Binder agreed.

"If an officer is so concerned with avoiding being on someone's chest, back or neck during a fight because they don't want to be out of policy and afraid they will restrict the person's airflow, then they're not concentrating on the most important task at hand, which is taking this person into custody in the most safe manner, both to the subject and the officer," Binder said.

To address this concern, the council agreed to specify that "intentional tactics" that restrict blood flow to the head or neck are prohibited. Binder and Smith both supported the consensus, which carves out an exception for accidental impediments to air flow.

"If someone falls on someone's chest at a fight, that's an accident," Smith said. "But we've seen nationally, across the country, where now the mantra for many marchers is "Hands up! I can't breathe!" and the reality is we are asking that the intentional tactics are listed out and put there."

The council also requested that the Police Department expand and clarify its use-of-force policy and that it adopt a requirement that "all options would be exhausted before shooting." It also supported a policy that bans police from shooting at vehicles unless the driver poses a "deadly threat." Jonsen and Binder each argued against an outright ban on shooting at moving vehicles, and pointed to situations in which someone may be trying to drive into a crowded demonstration or an outdoor dining area.

"The one predictable thing about police work is that it is unpredictable," Binder said. "We can pass a policy measure tonight that says, 'No doing that,' and there could be a demonstration in Foothills Park where someone decides they're going to drive into the crowd and that officer doesn't have the ability, based on totality of circumstances, to stop that threat with their firearm because they've been restricted by policy."

The council and the commission agreed that the Monday changes are just a small, early step in the city's campaign to revise police policies. Numerous residents offered a similar message.

Aram James, a former public defender and longtime police watchdog, argued that the department needs a culture change and better accountability, including the firing of officers who had been engaged in racist behavior.

"You can tinker with all the policies that you want," James said. "You can change all the policies every six months. The problem is, absent accountability and the ability to swiftly discipline and prosecute officers, this department's officers will not be even disciplined internally."

Other residents urged the council to follow the Human Relations Commission recommendations and align the Palo Alto Police Department with 8 Can't Wait. Cari Templeton, chair of the Planning and Transportation Commission who is running for council, said the reforms are "literally the least we can do." Two other challengers for council seats, Rebecca Eisenberg and Steven Lee, similarly urged the council to go further.

Lee, an outgoing member of the Human Relations Commission, asked the council not to "water down" the prohibitions on use of force with caveats and half-measures.

"It would certainly send the wrong message that Palo Alto wavers in fully implementing basic reforms and that we fail to do the very bare minimum," Lee said.

Eisenberg said the council has "no excuse whatsoever" to tone down any of the measures recommended by 8 Can't Wait.

"We need significant structural change if we're going to address white supremacy, segregation and violence against our Black and brown communities," Eisenberg said.

The council's vote directs City Manager Ed Shikada and department brass to work with the police unions to implement the new policies. The council is also moving ahead with broader efforts to address racial injustice and police transparency.

One of the council's ad hoc committees is putting together a series of programs for the next year that focus on diversity and inclusion, including citywide training on implicit bias, a demographic analysis of the city's workforce and development of permanent artwork that pertains to race and equity.

Other committees are focusing on ways to improve the Police Department's transparency and accountability, hiring practices and policies and alternate service models.

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BioAge Discovers Key Pathway and Identifies Promising Phase 2 Ready Drug to Treat and Reverse Immune Aging, a Root Cause of COVID-19 Morbidity and…

Posted: at 3:54 pm

BioAge Plans Phase 2 Clinical trial in Hospitalized COVID-19 Patients

Clinical development plan supported by potent inhibition of PGD2 DP1 Receptor by BGE-175, activating immune-modulating mechanisms that result in 100% survival in aged preclinical models of coronavirus

BioAges proprietary human aging data links activation of PGD2 DP1 signaling to increased risk of mortality and susceptibility to infections

RICHMOND, Calif., Aug. 25, 2020 (GLOBE NEWSWIRE) -- BioAge Labs, Inc., a biotechnology company developing medicines to treat aging and age-related diseases, today announced that it has in-licensed a clinical-stage therapy with significant promise and potential in treating immune aging in older patients hospitalized with COVID-19. The compound, BGE-175, is a potent orally administered inhibitor of the prostaglandin D2 (PGD2) DP1 signaling pathway associated with increased risk of mortality, and susceptibility to infections. The company recently generated preclinical data showing significant immune-modulating and anti-viral activity of BGE-175 which resulted in 100 percent survival in a preclinical model of the SARS 1 virus. In addition to fully protecting infected mice from death and improving morbidity, treated mice showed a 10-fold decrease in virus in their lungs. BGE-175 has demonstrated clinical activity and safety in a large number of subjects across multiple clinical trials for another indication.

Aging is the largest risk factor for COVID-19 morbidity and mortality, said Kristen Fortney, Ph.D., BioAges Chief Executive Officer. BGE-175 has the potential to restore the function of several key immune mechanisms that become dysregulated with aging, and that are critical to mount an effective response to major immune challenges such as COVID-19, SARS, and pandemic influenza. We plan to advance BGE-175 into a Phase 2 clinical trial in COVID-19 patients to evaluate whether its unique mechanism can improve patient outcomes by directly targeting immune aging.

Dr. Fortney added, Our AI-driven analysis of our proprietary human aging data maps out how the immune system is dysregulated during aging. Beyond COVID-19, BGE-175 has the potential to address other diseases driven by immune aging. BGE-175 is the second in a growing pipeline of promising therapeutics that BioAge will bring forward to treat diseases of aging.

BioAges preclinical data, obtained in collaboration with coronavirus expert Stanley Perlman, M.D., an American Academy of Microbiology fellow, and professor at the University of Iowa, shows that DP1 receptor antagonism elicits a potent protective response in a mouse model of SARS-coronavirus viral challenge.

Dr. Perlman noted, We have found over the past several years thatan age-dependent increase inDP1 signaling contributes to worse outcomes in the context of mouse infection with several human pathogens.We havepreviously shownimproved outcomes when DP1 signaling is genetically blocked, but BGE-175 is the first drug that has the same effect.BGE-175 may help counteract deleterious immune changes that occur with aging.

These preclinical data are particularly impressive and highly differentiating to support the potential of BGE-175 in COVID-19, said Adolfo Garcia-Sastre, Ph.D., Professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at The Icahn School of Medicine at Mount Sinai in New York City. While others in the field have used cellular models, BioAges preclinical data in a coronavirus preclinical model may offer more predictive translation of potential in clinical trials.

The pathways impacted by BGE-175 are linked to lifespan and healthspan in BioAges proprietary human aging data. The prostaglandin pathway, as well as several key components of the immune response to viral challenge, are significantly associated with longevity and multiple functional measures. Inhibition of PGD2 DP1 receptor signaling impacts multiple immune mechanisms, including activation of dendritic cells and NK cells, and reducing neutrophil infiltration. Preclinical studies demonstrate that BGE-175 inhibits neutrophil migration and that DP1 inhibition boosts dendritic cell function, both of which counteract known aspects of immune aging, and are also therapeutically promising for COVID-19 and other respiratory infections.

BGE-175 has demonstrated clear target engagement with inhibition of PGD2 signaling and safety in a large number of subjects across multiple clinical trials in another indication. Based on its groundbreaking research on the potential of BGE-175 for COVID-19, BioAge was granted a binding Letter of Intent from an undisclosed pharmaceutical company to enter into an exclusive license agreement to develop and commercialize BGE-175 for treatment and prevention of COVID-19 infections in the United States, Europe and the United Kingdom. Furthermore, for a one-year period BioAge has the exclusive option to license additional rights for other disease indications. Under the terms of the LOI, BioAge will make an upfront payment and contingent development and regulatory milestone payments plus royalties based on annual net sales. BioAge will be responsible for all development, manufacturing and commercialization of BGE-175 for treatment or prevention of COVID-19 infection in the United States, Europe and UK. Further details of the agreement will be released after additional patents applications are filed.

About the BioAge Platform The BioAge platform identifies key drug targets that will impact aging. The Companys proprietary human aging cohorts have blood samples collected up to 45 years ago, with participant -omics data that is tied to extensive medical follow-up records including detailed future healthspan, lifespan and disease outcomes. BioAge has built a systems biology and AI platform that leverages these rich datasets to identify the molecular drivers of age-related pathology. BioAges pipeline of therapies targeting these key pathways will address the significant unmet medical needs of an aging population.

About BioAgeBioAge is a biotechnology company developing proprietary drugs to treat aging and aging-related diseases. Since its founding in 2015, the Company has raised $37 million in venture capital funding from Andreessen Horowitz, Khosla Ventures, Felicis Ventures and others to back its AI-driven approach to map the molecular pathways that impact human longevity. BioAges mission is to develop a pipeline of therapeutic assets that increase healthspan and lifespan.

Source: BioAge Labs, Inc.

Contact Information:BioAge | peng@bioagelabs.comMedia | swheeler@wheelhouselsa.com

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Longevity and Anti senescence Therapy Market Size The Daily Chronicle – The Daily Chronicle

Posted: at 3:54 pm

The Longevity and Anti senescence Therapy Market Research Report published by Prophecy Market Insights is an all-inclusive business research study on the current state of the industry which analyzes innovative strategies for business growth and describes significant factors such as top developers/manufacturers, production value, key regions, and growth rate. Impact of Covid-19 pandemic on the market will be completely analyzed in this report and it will also quantify the impact of this pandemic on the market.

The research study encompasses an evaluation of the market, including growth rate, current scenario, and volume inflation prospects, based on DROT and Porters Five Forces analyses. The market study pitches light on the various factors that are projected to impact the overall market dynamics of the Longevity and Anti senescence Therapy market over the forecast period (2019-2029).

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Functioning liver cells regenerate in pig lymph nodes, and a human trial is coming – FierceBiotech

Posted: at 3:54 pm

Hepatocytes in the liver can naturally regenerate, provided the organ is completely healthy. But when the liver is diseased, it has too much scar tissue to nurture the environment hepatocytes need to replenish themselves.

In a new study published in Liver Transplantation, researchers led by the University of Pittsburgh School of Medicine demonstrated that pigs can grow functioning livers in their abdominal lymph nodes after their own hepatocytes are isolated and injected into them. A startup founded by three of the researchers, LyGenesis, is working to bring the method into human clinical trials.

Senior author Eric Lagasse, Ph.D., associate professor of pathology at Pitt, first demonstrated a decade ago that healthy liver cells injected into the lymph nodes of mice with malfunctioning livers would regenerate and take over normal liver functions. To further prove out the concept, Lagasse wanted to replicate the work in a larger model.

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So Lagasse and his team took pieces of healthy liver tissue from six pigs while at the same time cutting off the main blood supply to the organ. They then injected the cells into abdominal lymph nodes. All six animals were able to regain normal liver functions, they reported.

When they examined the lymph nodes, the researchers discovered a plentiful supply of hepatocytes, along with bile ducts and vasculature that had formed in the transplanted cells.

"It's all about location, location, location," Lagasse said in a statement. "If hepatocytes get in the right spot and there is a need for liver functions, they will form an ectopic liver in the lymph node."

RELATED: Liver-focused Ambys launches with $140M, Takeda partnership

Regenerative approaches to treating liver disease have generated enthusiasm among private investors. In 2018, for example, Third Rock Ventures launched Ambys Medicines, which is developing both cell and gene therapy approaches to regenerating hepatocytes.

LyGenesis, which was founded in 2017, got a major boost in May of the following year when it pulled in $3 million in a series A round from Juvenescence, a U.K.-based fund that has raised $165 million to support longevity-focused companies. In October of last year, Juvenescence and Longevity Vision Fund handed LyGenesis another $4 million in private financing and convertible notes.

LyGenesis is gearing up to start a phase 2a clinical trial of its technique in people with end-stage liver disease later this year.

The new animal study follows previous work by Lagasse and colleagues demonstrating that liver tissue grown in the lymph nodes of pigs with a form of genetic liver disease could treat the condition effectively. The researchers believe the technique could ultimately help people with a wide range of liver-damaging diseases, including hepatitis and alcoholism.

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Cellular Reprogramming Tools Market 2020 (Covid-19 Impact) In-depth Industry Analysis By Types, Applications and Forecast 2026: Celgene, Cynata,…

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Major Company Profiles operating in the Cellular Reprogramming Tools Market:

CelgeneCynataAdvanced Cell TechnologyBIOTIMEOsiris TherapeuticsHuman LongevityFUJIFILM HoldingsSTEMCELL TechnologiesMesoblastAstellas PharmaEVOTECJapan Tissue Engineering

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Adult Stem CellsHuman Embryonic Stem CellsInduced Pluripotent Stem CellsOther

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Drug DevelopmentRegenerative MedicineToxicity TestAcademic ResearchOther

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What are you doing to increase your Brainspan? – Longevity LIVE

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These days its easy to feel frazzled and distracted. You may be multi-tasking and not getting enough sleep. Maybe youre anxious. And youre probably not doing enough to help your brain work efficiently. If you want to remain sharp and clear-headed as you age, taking care of your brain should be top of mind, says functional medicine expert Bryce Wylde, author of the newly released book Brainspanners.

Accumulation of toxins is associated with cognitive decline, which makes detoxifying essential.

While the brain is designed to detoxify itself, over time this process may become less efficient. Your brain may also be overwhelmed by the sheer amount of toxins its exposed to from the environment and your diet. Thankfully, there are ways you can support your brains detoxification process, says Wylde. And doing so may increase your Brainspan.

Your lifespan is the number of years youll spend on this planet. Healthspan is the number of years you will live in good health. Brainspan, explains Wylde, is the number of years you will live in good health with the healthiest brain possible.

You probably know how much you weigh, and possibly your cholesterol levels and blood pressure. But Wylde says, most people dont know what their brain is doing. We dont give our brain the attention it deserves. Yet it controls the heart, gut and every organ in the body. We arent taught a lot about how to make it healthier.

Wylde says that some of the more efficient ways to support your brains detox process include: M

While many people only think of folate as a necessary nutrient during pregnancy, it is very active in the brain and central nervous system. It also aids in cellular detoxification. Vitamin B9 is found in many fortified foods, as well as fresh fruits and vegetables including nuts and leafy green vegetables.

Glutathione is the most important detoxification molecule, essential for getting rid of harmful chemicals and metabolic byproducts that are dangerous to the human brain. The body makes glutathione but depending on our genetics, some of us are more efficient than others at making it.

Also, our ability to manufacture glutathione declines with age. Others cant get into the cells. Research has shown that a new compound called Glyteine, now available over the counter as Continual-G, raises the cellular levels of glutathione rapidly, within an hour or two.

Our brains do most of their detoxifying when were in deep, non-REM sleep. Thats when the spaces between the brains cells enlarge, and accumulated waste can be flushed away. This cant happen during waking hours. It would be like a railway crew trying to repair tracks while the trains are running.

Wylde explains that toxins lurk everywhere. These include bleach in the laundry room and chemicals in foods and cosmetics. Youve got to pee, poop, sweat, or breathe out these toxins. When your output is less than your input, your brains health may be compromised.

We spoke to Bryce Wylde about how doing something for your brain, every day, is the best thing you can do to ensure its longevity.

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What This Cardiologist Wants You To Know About Vitamin D & Longevity – mindbodygreen.com

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While there's a genetic component to telomere length and durability, there seem to be a few things we can do to help support our own telomeres. Steven Gundry, M.D., heart surgeon and bestselling author of The Longevity Paradox: How To Die Young at a Ripe Old Age, shared an easy one when he appeared on the mindbodygreen podcast: Make sure you're getting enough vitamin D.

"Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob, referring to research in the Archives of Medical Science and the Journal of Nutrition on the association between telomere length and vitamin D levels.

It seems that vitamin D, a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase, the building blocks of telomeres that protect cellular DNA from aging. Gundry goes so far as to say that he thinks it's "the greatest hormone that exists."

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Adrenomyeloneuropathy Treatment Market 2020 (Covid-19 Impact) In-depth Industry Analysis By Types, Applications and Forecast 2026: Ascend…

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The report on the Global Adrenomyeloneuropathy Treatment Market has been prepared after conducting a comprehensive research through a systematized methodology. These skills are useful for scrutinizing the market on the terms of outlined research guidelines. Mainly, global Adrenomyeloneuropathy Treatment market research report covers all the information about the target audience, manufactures, vendors, research papers, products and many more. Keeping a focus on the overall market aspects, and perceptions, this report vastly covers profiles of the companies who have made it big in this particular field along with their sales data and other data. It also suggests the business models, innovations, growth and every information about the big manufacturers that will be present the future market estimates. Every market consists of set of manufacturers, vendors and consumers that gives a definition to the market, its each and every move, achievements. All these are the important subjects required to study the analysis of the global Adrenomyeloneuropathy Treatment market.

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Major Company Profiles operating in the Adrenomyeloneuropathy Treatment Market:

Ascend BiopharmaceuticalsImmatics BiotechnologiesHuman LongevityNovadip BiosciencesBioRestorative TherapiesEureka TherapeuticsCytori TherapeuticsAllogene TherapeuticsRegeneusNewLink GeneticsTalaris Therapeutics

By the product type, the market is primarily split into:

Steroid Replacement TherapyStem Cell Transplant

By the application, this report covers the following segments:

HospitalsClinicsAmbulatory Surgical CentersOthers

The data offered in global Adrenomyeloneuropathy Treatment market report is gathered based on the latest industry news, trends, as well as opportunities. This study offers a separate analysis of the major trends in the existing market, mandates and regulations, micro macroeconomic indicators is also comprised in this report. By doing so, the study estimated the attractiveness of every major segment during the prediction period.

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Moreover, the report comprises the analysis of opportunities available in the Adrenomyeloneuropathy Treatment market on the global level. It also includes the major market conditions across the globe such as the product profit, price, production, capacity, demand, supply, as well as market growth structure. The annual progression for the global Adrenomyeloneuropathy Treatment market in different regions cannot always be listed down as it will keep changing, thus studying and reviewing markets occasionally becomes vital.

In addition, the Adrenomyeloneuropathy Treatment market report provides a detailed information about the key market players along with the strategies they implemented to gain market existence and develop themselves. The report includes precise market estimations depending on current market status and future market forecasts.

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Adrenomyeloneuropathy Treatment Market 2020 (Covid-19 Impact) In-depth Industry Analysis By Types, Applications and Forecast 2026: Ascend...

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The pandemic threatens how we naturally grow and benefit from relationships – CNN

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Our brains have established methods for recognizing people as close friends or acquaintances, and "the closest ties are built on a substantial investment of time and trust both of which may be challenged by the current pandemic," said Andrea Courtney, a postdoctoral research fellow in psychology at Stanford University in California, who wasn't involved in a newly released review on social bonds. How humans develop and maintain relationships with friends and family is similar to the behaviors of societies in our evolutionary history and those of other primates, according to the review published Tuesday in the journal Proceedings of the Royal Society A: Mathematical and Physical Sciences.

Although many of us live in cities along with millions of other people, our personal social worlds contain anywhere from 78 to 250 people, with an average of about 154 individuals. That means that most people interact with a small number of other people and those people remain relatively stable over time, according to review author Robin Dunbar, a professor emeritus of evolutionary psychology in the department of experimental psychology at the University of Oxford in England.

These people are organized into layers within social networks, and those layers are dependent on cognitive, emotional and time constraints on our capacities for interaction.

The organization of our cognitive social networks

These networks consist of layers in accordance with relationships of varying quality: People considered to be intimates (family) and close friends are close in proximity and small in number. Types of friends and acquaintances extend further away from someone and grow in numbers.

How both humans and animals bond

The bonding process in both primates and humans is complex and time-consuming, the review said.

When animals are faced with the issue of maintaining group stability amid stresses, the solution is bonded relationships, which help ensure that members will behave similarly to one another and stay together. Primates accomplish this bonding by social grooming an activity that is time-consuming, but can also create a sense of reciprocity, obligation and trust.

Endorphins are fleeting, so their need for constant activation to maintain bonding levels make bonding time-consuming.

Laughing, singing, dancing, storytelling, eating and drinking are activities that, when done with others, can trigger the endorphin system in a way that is time efficient and "grooming-at-a-distance," the review said.

Virtual activities "slow down the rate of decay on relationships, but they won't stop them (from) dying eventually," Dunbar said in an email.

"Face-to-face is necessary for that, it seems. There is something very special about being able to see the whites of their eyes across the table, to reach out and touch them, that no digital media can yet match."

Seven pillars of friendship

Our knowledge of other people, which is built up by being in close contact, helps us bond and increase trust that others will meet our needs.

Emotional and physical closeness

At the core of human and primate friendships are being close in terms of spatial proximity and feeling close by emotional proximity, influenced by the time spent together.

"These ensure that bonded individuals stay together so that they are on hand when support is needed," Dunbar said in the review.

To hold someone in your close friends layer, you need to see them at least once a week; the best friends layer at least once a month; the friends layer at least once a year, Dunbar said.

"Drop below those rates, and the person will slip into the layer below within a few months," he added. "This is because the time you invest in direct interaction with someone determines the sense of emotional closeness you have with them -- and the sense that this is mutual."

The social and health consequences of personal ties

Trust and time available are crucial to social networks. When those are threatened by internal stressors or external threats (like a pandemic), relationships are at risk for declines in emotional strength, major upheavals or ultimately breaking down.

Because of the greater likelihood of forgiveness and inherent bond, family members have appeared to bounce back from the lack of opportunities to interact, Dunbar said. Friendships require more investment for constant connection and are more likely to fade when under threat.

Social breakdowns could have ill effects for our health, well-being and longevity, the review said. The number and quality of close friendships a person has can affect his or her happiness and capacity to recover from illness. Smaller social networks are associated with greater feelings of isolation and loneliness, which can affect rates of disease and death.

In light of the social distancing, quarantining and lockdowns imposed by Covid-19, Dunbar anticipated a few likely effects: a weakening of friendships that could make for awkward reunions; an increased effort to contact old friends after lockdowns; and fear of contracting the virus to reduce how often some people (introverts and the psychologically more cautious) visit places where they would encounter people they don't know.

The inability to assess the behaviors and infection risk of low-rank friends and distant family members could result in smaller, more inverted social networks, Dunbar predicted. Network patterns may return to normal within a year, but some friendship ties might be weakened enough to become acquaintances, the review said.

"Focusing more time on close relationships may boost well-being in the short term," Courtney said in an email. "In fact, recent research has observed a decrease in loneliness following the pandemic this may reflect the fact that many people are now clinging to their closest ties. ... Although physical contact is now much more limited, many of these other (virtual) bonding opportunities are just as abundant as ever."

To keep up relationships, emotional closeness and trust during this time, stay in virtual touch as much as possible, Dunbar suggested.

And remind your loved ones, "I'm still here and thinking of you."

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The pandemic threatens how we naturally grow and benefit from relationships - CNN

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