Monthly Archives: October 2019

Global Cell Therapy Technologies, Companies & Markets During the Forecast Period, 2018-2028 – ResearchAndMarkets.com – Business Wire

Posted: October 10, 2019 at 12:45 am

DUBLIN--(BUSINESS WIRE)--The "Cell Therapy - Technologies, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. The role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. The current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

The cell-based markets was analyzed for 2018 and projected to 2028. The markets are analyzed according to therapeutic categories, technologies, and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer, and cardiovascular disorders. Skin and soft tissue repair, as well as diabetes mellitus, will be other major markets.

The report contains information on the following:

Key Topics Covered:

Part I: Technologies, Ethics & Regulations

Executive Summary

1. Introduction to Cell Therapy

2. Cell Therapy Technologies

3. Stem Cells

4. Clinical Applications of Cell Therapy

5. Cell Therapy for Cardiovascular Disorders

6. Cell Therapy for Cancer.

7. Cell Therapy for Neurological Disorders

8. Ethical, Legal and Political Aspects of Cell therapy

9. Safety and Regulatory Aspects of Cell Therapy

Part II: Markets, Companies & Academic Institutions

10. Markets and Future Prospects for Cell Therapy

11. Companies Involved in Cell Therapy

12. Academic Institutions

13. References

For more information about this report visit https://www.researchandmarkets.com/r/9q5tz1

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Global Cell Therapy Technologies, Companies & Markets During the Forecast Period, 2018-2028 - ResearchAndMarkets.com - Business Wire

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NSF funds research on nitrogen fixation | The Source – Washington University in St. Louis Newsroom

Posted: at 12:45 am

The word agriculture conjures up an array of images: endless fields of corn stalks, amber waves of grain, the deserts of Africa Africa? While thoughts of the African landscape may tend to invoke a dry and empty countryside, scientists at Washington University in St. Louis are working to develop self-sustaining plants that could eventually turn the Sahara into a sea of green.

Himadri B. Pakrasi, the Glassberg Greensfelder Distinguished University Professor in the department of biology in Arts & Sciences and director of the International Center for Energy, Environment and Sustainability (InCEES), and Costas D. Maranas, professor of chemical engineering at Penn State, were recently awarded a $1.2-million grant from the National Science Foundation for their collaborative study of systems biology. Specifically, the Pakrasi and Maranas labs hope to decode the inner workings of cyanobacteria for the ultimate purpose of producing nitrogen-fixing crop plants.

For more than a century, farmers around the world have relied heavily on chemical fertilizers to help grow their plants and crops. Fertilizers contain nitrogen, an essential building block for all life forms to grow, and an element that is abundant in the earths atmosphere. However, creating man-made fertilizers is an energy intensive process that contributes to greenhouse gases and leads to run-off issues that severely damage the environment. A solution to this problem is to engineer plants to absorb nitrogen from the atmosphere and convert it into fertilizer, a process known as nitrogen fixation, so that the plants would become self-sufficient.

If you have engineered seeds that you give to an African farmer, that farmer can then plant the seeds, which gives rise to a field of crops that would not need chemically synthesized fertilizer to grow, Pakrasi said. This has huge agricultural implications not just for the affluent, Western world,but to the areas hardest hit by climate change.

Easier said than done. Nitrogen fixation cannot take place in the cells of most photosynthetic organisms plants that convert sunlight into energy because when plants are undergoing photosynthesis, a byproduct is oxygen. And oxygen is like a poison when it mixes with nitrogenease, the enzyme that enables nitrogen fixation. However, there is an organism that can accommodate both photosynthesis and nitrogen fixation in the same cell: cyanobacteria.

Just like human beings, cyanobacteria have a robust circadian rhythm a 24-hour biological cycle during which they photosynthesize in the day and fix nitrogen at night. Scientists have long studied these bluish-green creatures, but do not have a detailed understanding of how circadian rhythms allow cyanobacteria to adjust its metabolism for both nitrogen fixation and photosynthesis to take place in the same cell. With advances in genetic modification tools, it is now possible to probe deeper into the details of this process.

There are still missing parts of the cyanobacterial puzzle, Pakrasi said. The only way to identify what those missing parts are is to actually go into the cyanobacterium and tease apart the machinery. And thats what this grant will allow us to do.

In other words, the Pakrasi lab will perform a series of genetic modifications to the cyanobacteria and generate new data. The Maranas lab will then take the data and develop a predictive model for the inner working of the cyanobacterium. This iterative process will take some time, but the research is imperative to combating the climate changes facing the planet, Pakrasi said.

Its kind of like building an electric pickup truck, Pakrasi said. How do you go from a gasoline fueled car to a Tesla pickup truck? The basic technology for making a gas fueled car is already known, but were moving to a new paradigm of production in the form of a Tesla truck. Once we figure it out, we can deploy the new technology to our partners all over the world.

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What We Are Reading Today: 1491 by Charles C. Mann – Arab News

Posted: at 12:45 am

PARIS: Few spots in todays world have remained mysterious to todays archaeologists and scientists, armed with the latest, hi-tech tools that enable them to visualise and recreate the world as it may have been thousands, or even millions, of years earlier.

Yet, AlUla, located on an important route with links to Damascus, Europe, Asia, Africa and the Arabian Peninsula, continues to remain hidden in a veil of mystery even as teams experts try to pry open the diverse region to understand its origins and history.

Lying on the route that connected Aden in the south to Damascus in the north, and from there onwards to Europe, AlUla is believed to have been on the crossroads of several civilizations and multiple cultures. It was an important resting place on the trade route, with its abundant water supply feeding several oases and lush green farms.

Since the emergence of Islam, it has also been an important site on the route connecting most of northern Middle East and Africa with Makkah and Madinah.

A dedicated team of French and Saudi archaeologists, historians and researchers, assisted by a host of experts from around the world, has been trying to rebuild the story of AlUla since prehistoric times right up to today. Dr Laila Nehm, a French historian and archeologist, has been involved in uncovering the mysteries of AlUla for nearly 30 years. She and her colleagues have been able to fill in many holes in the sites timeline and reconstruct, using a clutch of modern tools and computer software, a fairly comprehensive story of a site that appears to have been continuously inhabited by humans for more than 200,000 years.

This is the story being told in a breathtaking exhibition entitled AlUla Wonder of Arabia that has been organized by the Royal Commission of AlUla, in collaboration with the French culture ministry and the Institut du Monde Arabe (Institute of the Arab World) in Paris. The exhibition showcases all aspects of AlUla and its evolution in the past 200,000 years, including 7,000 years of human inhabitation.

Covering more than 30,000 square kilometers, an area equivalent to that of Belgium, AlUla has seen several transformations in its geological as well as zoological composition. An impressive 3D model of the region, illuminated by computer software, recreates the geological and natural evolution of the region, with a range of diverse incidents such as large-scale floods, immense volcanic eruptions and of course the seemingly endless desertification.

All of these incidents have had a huge impact on AlUlas history and this is what is recreated in the exhibits at the IMA.

The exhibition, was inaugurated on Monday by the Saudi Culture Minister Prince Badr bin Abdullah bin Farhan and Franck Rieter, the French culture minister, as well as Jack Lang, the President of the IMA and a former French minister.

Nehm says that AlUla is literally a living museum, with its extremely well-preserved tombs, historic dwellings, monuments as well as captivating sandstone outcrops that hide in their hearts a largely untold story of more than 200,000 years of history. And despite the 30-years put in by her and dozens of other researchers, AlUla seems to be preciously guarding its secrets. For instance, Nehm says that it is very difficult to predict with any degree of certainty the human dimensions of AlUla, especially the variations in its population over the several cycles of ups and downs that the region clearly has seen over the course of its long history.

I would say it is difficult to put a finger on the exact figure of what might have been the maximum or even the optimum population of AlUla at a given time, notably in the early years of Dadanite and other pre-Roman eras. I might venture to say between 5,000 to 20,000, but it is only a guess and not based on any scientific certitude, Nehm told Arab News during a preview offered to leading media from around the world just before the official inauguration.

Another big mystery about AlUla is the transition between various kingdoms and empires. In the span of less than 800 years, from the 6th century BC to 2nd century AD, AlUla changed hands between the neolithic empires of Dadanites and Lihyanites and then onto the Nabateans from the Jordan valley and finally the Romans in the 2nd or 3rd century AD.

Despite the frequent changes, Nehm says the team of archaeologists has not been able to pinpoint the exact nature of these political changes.

We have not found any significant elements that can allow us to conclude that there may have been wars between the kingdoms, nor do we have any particular catastrophic moment that may have led to the change of power in AlUla.

For instance, if we had found traces of large-scale burnings or destruction at a particular time in history, we may have looked at possibilities like outbreaks of wars or diseases or even natural catastrophes. But here, so far, we have not yet found any such elements, says Nehm.

For Amr Al-Madani, the Chief Executive Officer of the Royal Commission of AlUla, these unresolved mysteries can only add to the allure of the region for not just scientists and researchers from all across the world, but tourists and those interested in learning about human civilization and its evolution as well as people that like nature and environment. AlUla has everything for anyone looking for any of these elements. It is a jewel of Saudi Arabia and we want to share this with the entire world and that is why we are mounting a series of events and activities to allow visitors from all over the world to come and enjoy at AlUla and relive the story of the evolution of human civilisation, Al-Madani said.

Amongst the several wonderful sights that await visitors in AlUla are thousands of rock inscriptions dating back to the prehistoric period and some of which also go on to show the evolution of the Arabic script as the Nabatean script slowly evolved into Arabic in the early centuries of the first millennium AD. AlUla also has hundreds of tombs built by Nabateans in the same style as in their most famous city, Petra, in Jordan. The most famous Nabatean site in AlUla is of course Mada'in Salih, also known as Hegra, which was recognised by UNESCO as the first World Heritage Site in Saudi Arabia.

AlUla is a repository not just of the beauty of human creations. There are plenty of natures wonders, too, for the visitors to admire. There are hundreds of sandstone and basalt rock outcrops, carved beautifully by nature over thousands of years that offer a breathtaking view.

Al-Madani said the Royal Commission of AlUla has planned a series of activities, beginning later this year, to allow visitors and tourists to relish the region, even though the site will be thrown open fully to tourists only in October next year.

While opening the AlUla to the world, Al-Madani also stresses that the royal commission will keep the focus on community involvement and sustainable tourism to ensure that not only the heritage of AlUla is well-preserved, but that the local community remains a major stakeholder and beneficiary of tourism and the cultural activities that would take place there. We need to be sure that we hand over AlUla to the future generations in the same unspoilt and well-preserved state in which we have inherited it, Al-Madani said.

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After 5 Years Of Trials, Doctors Create Human Liver From Scratch – CBS Pittsburgh

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PITTSBURGH (KDKA) In a dish sits a human liver.

Not removed from a person, but created from scratch.

Its not like wahoo and the next morning you think, ah, Im gonna make a human liver,' says Dr. Alejandro Soto-Gutirrez of the Pittsburgh Liver Research Center.

It took five years of trial and error but using stem cells, genetic and tissue engineering, organ cultures and a team of experts in these areas, the researchers have come up with this.

Alexandra Collin de Lhortet, Ph.D. of the University of Pittsburgh School of Medicine explains the process.

A rat liver gets stripped of its cells so that only the connective tissue remains.

From a small piece of human skin, the scientists pluck out stem cells and coax them into becoming human liver cells and the cells are collected.

Then theyre injected into the chamber, called a bioreactor, where they take up residence in the empty rat liver.

The entire process from gathering the cells to make a liver, to get to this point, where you have an actual mini human liver in a bioreactor, takes several months.

It will stay alive, or viable, for only a few days.

But in that short time, the researchers can try different medicines to treat the diseased liver.

You could test any sort of therapeutic by simply injecting this chemical through the system, says Dr. Collin.

In the past, animal livers played a role in this kind of research but human livers didnt always respond in the same way.

With this system, the cells have had genetic modification to recreate diseases, for example, fatty liver, a growing problem in the United States.

This technology has the potential for personalized medicine. From your skin cells, they could grow your own mini liver to figure out which medicines would work for you.

I believe its a very good biological tool to screen treatments that are not otherwise being tested in humans themselves because its dangerous, says Dr. Soto.

As its designed, it would be a long stretch to create livers for transplantation.

If you mean how far we are to make actual livers for people, I think we are very far away. Were probably many years away. But this is a good step, Dr. Soto says.

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Armenia has young but very clever IT community – Jamie Metzl – Armenpress.am

Posted: at 12:45 am

17:55, 7 October, 2019

YEREVAN, OCTOBER 7, ARMENPRESS. Technology futuristandgeopolitical expert, novelist Jamie Metzl is familiar with the technology sphere of Armenia. He has noted that the IT community in Armenia is young, but very clever, Metzl spoke with ARMENPRESS in the sidelines of the IT congress in Armenia.

I have some knowledge about the IT sector of Armenia, I am familiar with the activities of the Foundation for Armenian Science and Technology (FAST). Last year I was the keynote speaker of their conference and I will be the keynote speaker next year. Armenias IT community is very young but very clever. I know one thing about the Armenian people usually they are brilliant, there are brilliant chess players, brilliant thinkers, he said.

He noted that the majority of Armenias IT companies are young. There is no Armenian Intel, Apple or Microsoft. But Jamie Metzlnoted that we live in a de-centralized world, where companies can be located anywhere. According to him, Armenia has firm basis for creating future. He said its very possible that after 10 years there will be very important Armenian IT companies.

Metzlnoted that he has talked with numerous people and want to translate his book Hacking Darwin. Genetic Enginneering and the future of Humanity into Armenian. The book is about genetic engineering and the future of humanity and was published in the USA in April. There are translations of the book into numerous languages, but not into Armenia so far. I would like one of the publishing houses of Armenia to publish my book, because its about the revolution of genetics, about the past, present and future. The revolution of genetics is related with the IT revolution. And these technologies together will change the entire world, Jamie Metzl said, hoping that one of the publishing house of Armenia will contact him. It will be a great honor for me if my book is translated into Armenian, which is one of the super scientific languages of the world, he said.

Edited and translated by Tigran Sirekanyan

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Lab-grown Meat Produced in Space for First Time Aboard International Space Station – Newsweek

Posted: October 8, 2019 at 4:46 pm

An Israeli start-up has successfully cultured lab-grown meat in spacethe first time this has been achieved.

In a proof-of-concept experiment, Aleph Farmin collaboration with partners 3D Bioprinting Solutions, Meal Source Technologies and Finless Foodsproduced the meat aboard the International Space Space Station, which orbits the Earth at an average altitude of about 250 miles.

The latest method, which requires less resources than traditional animal farming,could potentially be used in future to produce food on long space missions, according to the company. They also say that the technique could have important implications for cultivating lab grown meat on Earth.

"In space, we don't have 10,000 or 15,000 liters (3,962 gallons) of water available to produce one kilogram (2.2 pounds) of beef," Didier Toubia, Co-Founder and CEO of Aleph Farms, said in a statement.

"This joint experiment marks a significant first step toward achieving our vision to ensure food security for generations to come, while preserving our natural resources," he said.

To create the cultivated beef steaks, Aleph Farms devised a method which mimics the natural process of tissue regeneration inside a cow's body.

The company harvested cow cells on Earth before launching them to the ISS. In the Russian segment of the space station, astronauts then created small-scale muscle tissue from the cells using a 3D bioprinter in the microgravity conditions.

The company say the experiment demonstrates that this cell cultivation process can generate food using minimal resources.

"This cutting-edge research in some of the most extreme environments imaginable, serves as an essential growth indicator of sustainable food production methods that don't exacerbate land waste, water waste, and pollution," the company said in a statement. "These methods are aimed at feeding the rapidly growing population, predicted to reach 10 billion individuals by 2050."

Recent scientific research has highlighted how traditional animal farming is a significant driver of climate change, and that cutting down on meat and dairy products is one of the best ways for individuals to curb their carbon footprint.

Lab-grown meat has been touted as one potential way to help mitigate the environmental impact of the animal farming industry as demand for meat rises around the world. At the moment no true lab-cultivated meat products are commercially available, however, this situation could change in the next few years as technology improves.

"The mission of providing access to high-quality nutrition anytime, anywhere in a sustainable way is an increasing challenge for all humans," Jonathan Berger, CEO of The Kitchen, said in a statement. "On Earth or up above, we count on innovators like Aleph Farms to take the initiative to provide solutions to some of the world's most pressing problems, such as the climate crisis."

In December 2018, Aleph Farms announced that it had produced the world's first lab-grown steak with a muscle-like texture, although they admitted at the time that the taste needed work.

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Catch a quick glance of the International Space Station in the South Jersey sky – Press of Atlantic City

Posted: at 4:46 pm

As I write these words, an originally clear weather forecast for this week has changed to a possibly very cloudy one. It all depends on whether a developing coastal low gets stuck and bedevils us for several days.

Despite this newer weather forecast, Im going to remain optimistic and tell you about two fine passes of the International Space Station scheduled for us tonight and especially Wednesday night. Our other topics today include the Hunters Moon this coming Sunday and a touch of Halleys Comet meteors two Mondays from now.

Tuesday and Wedneday nights good space station passes. Lets hope we at least get breaks in the clouds during evening twilight tonight and Wednesday night. If so, well get views of the ISS the International Space Station from here in South Jersey.

Tonights pass is most interesting when the ISS is on the verge of passing into Earths shadow. At 8:02 p.m. tonight, look for a point of light brighter than any other, partway up the south sky. At 8:03:55 p.m. it is not greatly far to the right of the moon when suddenly in just a few seconds it will fade completely from view. What has happened is that the ISS, more than 200 miles above Earths surface, has finally entered into Earths shadow a few hundred miles southeast of Bermuda.

Wednesday nights ISS pass is brighter, higher in the sky, and goes closer to the moon in our sky. It does occur much earlier in twilight. But around 7:13 p.m. you should see the ISS weather permitting climbing from out of the northwest sky. The brilliant point of the ISS appears virtually overhead for people in South Jersey as it passes approximately over Delaware Bay and near the bright star Vega. The space station fades somewhat as it heads down the southeast sky but is still prominent at 7:16:20 p.m. as it passes not far left of the big moon. The ISS fades into the earths shadow over the Atlantic a few hundred miles from North Carolina at 7:17:51 p.m.

Suppose the sky is overcast either? You can get a highly detailed simulated view of what it would look like from the space station itself as it passes by us. Just go to heavens-above.com and click on the feature ISS Interactive 3-D visualization. And whether you see the ISS in the sky or on a devices screen, just remember: this is a space station with solar panels that stretch across a span similar to that of two football fields all traveling more than 17,000 mph with human beings on board.

Hunters Moon: The most famous moon is Harvest Moon the full moon closest to autumn equinox, the start of autumn. But the next full moon has some of the same qualities including sometimes looking like a big orange-gold pumpkin as it rises around sunset. This moon, which usually happens in October, is called Hunters Moon. This year, the exact moment of full moon occurs at 5:08 p.m. on Oct. 12 this coming Sunday. Thats actually before moonrise here in New Jersey but dont worry: the Hunters Moon will look as round and fully lit as could be when it rises for us around sunset that day. And it will look that way all night long in fact, look almost full even the night before and after.

Can you see a Halleys C omet meteor? If the night of Oct. 21 to 22 is clear, scan the sky from around 11:30 p.m. to 12:30 a.m. for shooting stars from the east meteors from the Orionid meteor shower. The 40% lit moon rises right after that hour and so may hinder us seeing some of the larger number of Orionids youd normally expect from the southeast around 2 a.m. and from the south around 4 a.m. If, however, you see even just one of these Orionid meteors, youre seeing a very special bit of space rock burning high in our atmosphere. Why special? Because the Orionids are pieces of dust and rock released at past returns of the famous Halleys Comet.

Fred Schaaf is a local author and astronomer. He can be reached at: fschaaf@aol.com.

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Exploring Regenerative Medicine in Microgravity Aboard the International Space Station – UPJ Athletics

Posted: at 4:46 pm

Learning how everyday things work in space, such as how to effectively brush teeth or how hair grows, is intriguing, but knowledge of how medical research translates from Earth's surface to above its atmosphere is limited.

A new alliance between the McGowan Institute for Regenerative Medicine at the University of Pittsburgh and the International Space Station (ISS) U.S. National Laboratory aims to drive the progress of regenerative medicine research in microgravity environments specifically, aboard the ISS.

The questionis What can we do in space that we can't do on Earth that makes a difference?" said William Wagner, director of the McGowan Institute. "That's a pretty exciting question, because it's currently unanswered; we don't know what the key value of microgravity is. I think when we find that, we can attract investment, we're going to begin to identify what the most promising technology is."

The ISS National Laboratory and the McGowan Institute will collaborate with partners from industry as well as other academic research centers and government agencies to drive the progress of regenerative medicine research aboard the ISS. As part of this alliance, Pitt will develop facilities on campus to advance research and meet with potential partners, while working in coordination with the ISS National Laboratory on flight opportunities to the orbiting laboratory. The program will focus on microgravity life sciences research and development, with a line of sight toward products and services for clinical application on Earth.

"What has to happen now is knowing how we can leverage research into a treatment or technology that someone will invest in because it will replace the current way we do things here on Earth," Wagner said. "We are very enthusiastic about this, because we believe the time is right to move from the observational to the more practical, moving things toward commercialization. One of the things we're going to try to do is give industry the best and brightest research in our country, not just at Pitt, but other universities as well, to pitch different concepts and partner with those concepts to help develop them."

An example of this research in action could include exploiting the unique behavior of stem cells in microgravity in order to improve cell-based therapies for a variety of diseases and impairments, such as traumatic brain injury and type I diabetes. Similarly, microgravity could allow 3D printers to create complex tissue structures that are difficult to achieve in the presence of full gravity.

This alliance a core element of the ISS National Laboratory Industrial Biomedicine Program was unveiled at the 8th annual ISS Research and Development Conference held in Atlanta earlier this year.

University leaders are optimistic this alliance will be the next big step in space research and commercialization.

The McGowan Institute has built on its deep history advancing the development of artificial organs to establish a position of internationally recognized leadership in regenerative medicine, said Rob A. Rutenbar, senior vice chancellor for research at Pitt. The ISS National Laboratory will benefit from that deep expertise, as well as our commitment to rapid clinical translation.

The products of the Industrial Biomedicine Program will help build the fundamental business case for the industrialization of crewed platforms in low Earth orbit. In future alliances, the ISS National Laboratory will work with companies and research partners who seek to find solutions to common problems on Earth through space-based experimentation on the ISS National Laboratory.

The ISS National Laboratory is proud to announce this alliance with Pitt and McGowan in order to develop biomedical products in space that could benefit human health on Earth, said ISS National Laboratory Chief Strategy Officer Richard Leach. Part of the role of the ISS National Laboratory is to create and implement innovative strategies to enhance the research capacity of the orbiting laboratory, and we believe alliances like this will pave the way for future collaborations to advance the discoveries of space-based science.

More details about the alliance are available on the ISS National Laboratorys website.

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NSF/CASIS Collaboration on Transport Phenomena Research on the International Space Station (ISS) to Benefit Life on Earth – IIT Today

Posted: at 4:46 pm

The National Science Foundation Division of Chemical, Bioengineering and Environmental Transport (CBET) in the Engineering Directorate of the National Science Foundation (NSF) is partnering with the Center for the Advancement of Science in Space (CASIS) to solicit research projects under NSF 20-501, in the general field of fluid dynamics, particulate and multiphase processes, combustion and fire systems, thermal transport processes, and nanoscale interactions that can utilize the International Space Station (ISS) National Lab to conduct research that will benefit life on Earth. Only U.S. entities including academic investigators, non-profit independent research laboratories and academic-commercial teams are eligible to apply.

Please note that while the proposal deadline window is open until March 2020, the final deadline for submitting the required feasibility review form to NSF is January 10, 2020*. Please see the full announcement for additional details.

*If you are interesting in applying for this funding opportunity, please start a routing sheet as soon as possible. As a reminder, proposals must be completed and submitted to OSRP no later than January 8, 2020 for submission to the sponsor. If you should have any questions, please contact OSRP.

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NSF/CASIS Collaboration on Transport Phenomena Research on the International Space Station (ISS) to Benefit Life on Earth - IIT Today

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Brimstone battery bags on board Space Station – FW Business

Posted: at 4:46 pm

A fire protection products company in the Fort Wayne area has collaborated with a Reston, Virginia-based science and technology company to supply the International Space Station with lithium-ion Battery Fire Containment Bags.

Spencerville-based Brimstone Fire Protection partnered with Leidos on the project for the National Aeronautics and Space Administration, according to a prepared statement.

Leidos had NASAs ISS Vehicle Office and Johnson Space Center Battery Group cargo mission contract to develop a safe new packing product for lithium-ion batteries stored on the space station and teamed up with Brimstone for that.

Their new product was brought aboard the space station the last weekend of September.

NASA safety standards previously relied on extensive pre-flight screening of lithium-ion batteries and storage constraints once they were on board the space station.

But, the ISS has seen an influx of new, smaller payload providers, each using their own type of battery packs to power the equipment they are transporting there for experiments, the statement said.

This created a need for a standardized battery packaging product for NASAs Commercial Orbital Transportation Services, it said.

NASA, Leidos and Brimstone started an extensive process early this year of designing, then testing, packaging made specifically for battery storage in space.

A detailed series of frequent, repeated tests on Brimstones Fire Containment Bags, which started early this year, showed when used with an insulating wrap they prevented thermal runaway into other bags touching them.

This meets all the criteria for the envisioned NASA implementation, including size, materials, accessibility, packing density, and cost, the statement said.

Daniel Barineau, a Leidos senior project manager who has supported ISS and Space Shuttle hardware development projects for 30 years, praised Brimstone and its leadership for rapid delivery and frequent consultation, which included offering historical expertise on the development of the battery stowage bags.

I have had the chance to work with many subcontractors and suppliers. In all those years, I have never come across a company that was as responsive, customer focused, and easy to work with as Brimstone, he said.

They have modified their off-the-shelf designs to meet our needs and have shown a willingness to go above and beyond to make our efforts a success under a compressed schedule.

Recreational vehicle manufacturers, suppliers and dealers celebrated the opening of the newly renovated, 18,000-square-foot RV Technical Institute facility in Elkhart last month.

A grand opening for the facility there at 3333 Middlebury St. took place Sept. 23. Visitors had a chance to see its new office space, student lounge, seven classrooms and 10,000-square-foot bay area with RVs for hand-on training as well as component parts lesson areas.

Our dedicated staff have created a visionary, forward-thinking program designed to solve our industry-wide need for trained technicians, Curt Hemmeler, executive director for the institute, said in a statement.

Today marks the first step on that journey as we officially open our doors and invite students into our new facility to become trained technicians, expand on their existing education and launch the program to regional partners across the country.

The RV Industry Associations board approved a comprehensive strategic plan and a multi-million-dollar investment in the institute a couple of years ago to boost RV owner satisfaction and strengthen repeat business.

I believe in our new model for technician training and the impact increased tech training will have on the entire industry, Matt Miller, the institutes chairman, said in the statement.

This initiative will help close the skills gap, draw new talent into the growing RV industry, retain existing RV techs and ultimately create a better experience for our customers, the RV consumer, said Miller, who also is president of the luxury motor coach manufacturer, Newmar Corp.

The institutes strategic plan called for it to address the industrys trained technician shortage and establish metrics to track the RV customer experience with a goal of reducing repair event cycle times. The statement said it has received broad industry support.

We now have a standard, a uniform process for training, testing and certification that will be incorporated at a national level through a vast network of regional partners, Craig Kirby, the associations interim president, said in the statement.

Curt came into the process with a vision that combines both his business acumen and his experience within the education and training world. Curt will also tell you that as someone who got his start in the Air Force as a technician, at heart, he is still a tech himself, Kirby said.

Thinking like a technician allows Curt to view the Institutes mission through this lens, developing a program that includes improving the career path so we can better recruit and retain technicians across the country.

The association established the institute with a $5 million investment, which was matched by Go RVing, a consumer outreach campaign it manages with the RV Dealers Association.

Comcast Corp. is increasing broadband speeds for a most of its Indiana customers, who are on some of its most popular Xfinity Internet packages.

The Philadelphia-based provider of broadband, Cable TV and internet phone services started the upgrades late last month. It said it was increasing its Performance tier to 100 megabits per second from 60 Mbps, Blast! to 200 from 150, Extreme to 300 from 250 and Extreme Pro to 600 from 400.

Close to 85% of the companys Indiana customers are on one of the plans scheduled for the faster speeds and the upgrades will take place whether customers are buying Xfinity Internet as part of a package or on a stand-alone basis, the company said in a statement.

Comcast increased speeds for its Blast! and Extreme Indiana subscribers last year, and during the past two years its Indiana customers have seen speeds increase more than 50% on average, it said.

The increases are designed to keep pace with growing demand for high-capacity, extremely fast connections capable of handling an explosion of smart home devices with features requiring Internet access.

Comcast has doubled its fiber miles and quadrupled its network capacity to bring gigabit speeds to more homes than any other internet service provider during the past four years, it said.

Were not only delivering the broadband speed and capacity that customers need to run more sophisticated home networks, were setting the bar for coverage and control, too, Tim Collins, regional senior vice president for Comcast Indiana, said in the statement.

Modern homes require fast Internet, wall-to-wall Wi-Fi, and a way to manage the connectivity needs of the entire household. With xFi, were giving our Internet customers the tools to manage the growing number of connected devices, apps and technologies in their homes.

Customers who lease a gateway from the company will receive the upgrade without needing to reset their modems for it, the statement said.

The company recommends subscribers with their own modems check online to see if they will need a new one to handle the faster speeds.

Jason West of Digital Watchdog was scheduled to speak at the next meeting of the Networking Information Technology Associations Fort Wayne chapter.

West was to speak on internet protocol-based security trends and best practices to help protect employees and assets during the meeting scheduled for 11:30 a.m. Oct. 4 at Catablu, 6372 W. Jefferson Blvd. in Fort Wayne.

With a video security career of more than 15 years, West has helped design and install those types of systems for a variety of industrial, commercial, education, retail and residential customers.

In addition to creating safe environments, he works to design systems that are easy to use and are capable of providing court admissible evidence quickly.

For the rest of this year and next year, the local chapter of NITA said it plans to meet on the first Friday instead of the first Thursday of each month.

The Fort Wayne Inventors Club has scheduled its next meeting for 7 p.m. Oct. 10 at TekVenture, 1550 Griffin St. in Fort Wayne.

The group, formed to advance invention in the region, requires no dues or fees and asks only that individuals come to its meetings with a curious mind, desire to learn and a willingness to help fellow inventors.

More information about it is available from http://www.fortwayneinventorsclub.org or by contacting Dave Gross, president and CEO of Collision Control Communications.

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