Monthly Archives: September 2019

Daly City Hospital Survives Bankruptcy Again, But For How Long? – SF Weekly

Posted: September 21, 2019 at 1:41 pm

With a pending sale due for approval any day, Daly Citys hospital that largely serves low-income patients and seniors is no longer in immediate danger. But the instability still has staff and patients anxious about its long-term future after all, it was in the same position just four years ago.

The owner of Seton Medical Center, Verity Health, declared bankruptcy in August 2018, setting off a panic about what would happen to the safety-net hospital that roughly 27,000 people in southern San Francisco and northern San Mateo County rely on for emergency services. About 80 percent of those are MediCal and Medicare patients, who would have to travel farther for care even in life-or-death emergencies. Its also the largest employer in Daly City.

By January, Strategic Global Management, a subsidiary of KPC Group of Companies, emerged as the sole bidder, offering $610 million for Veritys four hospitals: Seton in Daly City, another Seton in Moss Beach, and two in Southern California. The California Attorney Generals Office held a public meeting in August and is expected to lay out its final sale conditions this fall, according to San Mateo County Supervisor David Canepas office. A judge approved the bid earlier this year.

We were pleased to participate in four separate public meetings in the communities surrounding all four hospitals being acquired by SGM, said spokesperson Jeff Corless in a statement. The meetings had broad employee, physician, elected official and community stakeholder participation. The consistent theme was, save our community hospital. That remains our top priority.

When Verity bought the hospital system from Daughters of Charity in 2015, the Attorney General imposed conditions which were designed to keep the hospital operating for at least 10 years. Just three years later, however, the hospital declared bankruptcy. Phoebe Minkler, a Seton nurse of 9 years, says colleagues are wearier this time around and less willing to stick around which makes it harder to train staff for the long haul.

A lot of people are scared about the future, says Minkler, whos represented by the California Nurses Association. We just heard this a few years ago its more promises. Were left in a kind of lurch again.

Minkler and her coworkers would like SGM to commit to investments like reopening labor delivery and establishing the cancer unit that Verity promised. But theyre also just hoping the hospital doesnt lose services at this point, and for the new company to commit to the seismic retrofits needed through 2030 that would signal a long-term investment running the property as a hospital.

Though the City Council of Daly City approved a resolution in 2018 to keep the land zoned for hospital use, fears remain that developers are eyeing the 32-acre site for lucrative housing. Extending the sale conditions another five years and following through on the retrofit would better ease those fears, says the National Union of Healthcare Workers, which represents about half of Seton workers.

The top priority for Seton workers is keeping the hospitals open with no decrease in medical services for the surrounding communities, said NUHW Research Director Fred Seavey in a statement. Were ready to work with the prospective owner to make that a reality, but its hard not to have concerns when the company has not committed to keeping the hospitals open long-term or seismically retrofitting Seton Medical Center.

Minkler and another Seton staffer, Rosalie Zamora, say patients have asked if the hospital is closing. Keeping Seton running at full speed is a matter of life or death to many, including longtime Daly City resident Elaine Villasper. Her family has gone to Seton for services since the 1990s but it became a lifeline for Villasper when she went into septic shock days after developing an infection during childbirth. She spent a week in the ICU recovering from organ failure and a stroke and was told that if they went to a hospital farther away, she may not have survived.

The doctors, nurses, and other medical staff provided great care to me and my family and I owe my life to them, says Villasper, who supports NUHW demands. A hospital is a key part of any community, and it would be detrimental not only to the workers, but to our city if the hospital was not able to provide its services.

Even with Setons future more secure than it was a year ago, Canepa feels a long-term fix is needed to the inequities of hospital services in San Mateo County. Hes starting to look at surcharges on for-profit hospitals concentrated in the southern, wealthier parts of the county to prevent financial strain on safety-net hospitals like Seton or the public San Mateo Medical Center.

Whats really fascinating to me is the schism between the haves and the have-nots, Canepa says. Daly City is really the symbol for that. We have a lot of MediCal and Medicare [patients], where are they going to go?

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Daly City Hospital Survives Bankruptcy Again, But For How Long? - SF Weekly

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Insys gets bankruptcy court okay for Subsys sale – PMLiVE

Posted: at 1:41 pm

Insys Therapeutics has been given the green light to sell its Subsys opioid product the focus of racketeering charges that forced the company to file for bankruptcy to BTcP Pharma.

Back in June, Insys became the first company to file for bankruptcy in connection with the US opioid epidemic, shortly after agreeing a $225m payment to settle charges it bribed doctors to prescribe Subsys.

Since then, Purdue Pharma has also filed for Chapter 11 protection as it tries to secure agreement for a massive $10bn-$12bn settlement relating to its alleged role in the opioid crisis, while Mallinckrodt has also been reported to be at risk as it tries to pursue its own settlement deals.

Subsys is a sublingual spray formulation of fentanyl, a highly-potent opioid analgesic that is approved to treat end-stage cancer pain, and is being sold to try to raise cash to satisfy creditors and provide funds for settlement of thousands more outstanding lawsuits.

Earlier this year, five former Insys executives including founder and chairman John Kapoor were convicted of racketeering conspiracy after being found guilty of encouraging widespread, off-label use of the product by providing inducements to doctors.

Wyoming-based BTcP Pharma, which is part of the MMB Healthcare network of pharmaceutical companies, has agreed to take over the sale and distribution of the drug and pledged to only market the drug for use in its approved indication.

It will also take on limited debts related to the Subsys product, but wont assume liability for fines, judgments, settlements or other liabilities owed to the Department of Justice or other governmental entity in other words the $225m federal settlement.

Insys will receive a 45% royalty rate on profits from Subsys, which it estimates could reach around $20m only a fraction of the amount being sought by claimants that also include states, municipalities and Native American tribes, as well as to insurers and hospitals affected by the racketeering.

The company estimates that its potential liabilities could be as high as $4bn, far in excess of any amount raised during its liquidation.

Other assets held by the company include Syndros, a liquid dronabinol product approved for chemotherapy-induced nausea and vomiting in patients who dont respond to other drugs, as well as a naloxone nasal spray formulation and a sublingual spray formulation of buprenorphine in development. The buprenorphine spray product was however rejected by the FDA last year.

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Insys gets bankruptcy court okay for Subsys sale - PMLiVE

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1st CF Biosimilar of Dornase Alfa Inhalation Solution Approved in Russia – Cystic Fibrosis News Today

Posted: September 20, 2019 at 3:45 am

A biosimilar of dornase alfa inhalation solution, with the same therapeutic activity asPulmozyme, its reference therapy, was approved foruse in Russia,Selexis and Generium Pharmaceutical announced.

A biosimilar is like a generic formulation of an approved biological treatment in that it is clinically similar to its reference medicine.

Named Tigerase, this is the first dornase alfa biosimilar made available anywhere in the world to treat people with cystic fibrosis (CF). We believe patients will be able to maintain a higher quality of life on our dornase alfa inhalation solution, Dmitriy Kudlay, MD, CEO of Generium, said in a press release.

CF is caused by mutations of the CFTR gene that prevent cells from managing their salt and water balance. This imbalance triggers an accumulation of thick mucus in the organs that include the lungs, resulting in inflammation, repeated bacterial infections, increased scarring (fibrosis), and the possibility of respiratory failure.

Pulmozyme, marketed by Genentech, has been a standard therapy for CF patients since it was first approved in the 1990s. It is a synthetic version of the human deoxyribonuclease I enzyme (or rhDNase I), which selectively breaks down the long strands of DNA sequences that contribute to mucus thickening. Pulmozymes use makes the mucus thinner and easier to cough up.

Used in combination with antibiotics, bronchodilators, and steroids, Pulmozyme can significantly improve airway flow and help prevent bacterial infections.

The new dornase alfa biosimilar was developed using Selexiss SUREtechnology Platform, which uses the companys proprietary, high-performance mammalian cell line (SURE CHO-M Cell Line) to generate higher yields and more stable production of recombinant proteins that can be used as therapeutic agents.

There are currently 122 clinical programs in development utilizing our platform. The increasing number of Selexis-generated research cell banks used in clinical programs, and now a sixth marketed product, continue to validate the value of our scientific innovation, said Igor Fisch, PhD, CEO of Selexis. We are extremely proud of our ability to help our partners address complicated and intractable diseases by developing complex protein therapeutics faster, safer and more cost efficiently.

Generium, a Russian biopharmaceutical company focused on diagnostic tools and therapies that include those for rare diseases, describes itself as the first worldwide to develop and market a biosimilar of dornase alfa.

The orphan drugs market has been growing significantly over the last several years. Biotechnology, as a science, is developing rapidly, providing new products for the treatment of the most severe and rare diseases, Kudlay said.

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1st CF Biosimilar of Dornase Alfa Inhalation Solution Approved in Russia - Cystic Fibrosis News Today

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Medical research in Birmingham improving lives of people with cystic fibrosis – Bham Now

Posted: at 3:45 am

Tr, a 24-year-old with CF, wearing his vest for chest physical therapy. Photo via the Cystic Fibrosis Foundation

Birmingham is a leader in cystic fibrosis (CF) research. Thanks to the work of the Cystic Fibrosis Foundation, UAB and Southern Research Institute, those with CF are receiving better treatments and living longer than ever. Learn more about CF and how you can get involved, including the Shoot for a Cure event on October 11.

Cystic fibrosis is a genetic disease that affects the lungs, pancreas, GI system and other parts of the body. People with CF have a defective gene that causes a buildup of mucus in the body, which leads to lung infections and difficulty breathing. Over time, the lungs become damaged, and the damage is irreversible. In the pancreas, mucus buildup can interfere with digestion and result in malnutrition.

According to the Cystic Fibrosis Foundation, more than 30,000 people in the U.S. have CF. Most people are diagnosed by two years of age.

David Cobb, board member of the Alabama Chapter of the Cystic Fibrosis Foundation, was diagnosed with CF as an infant. He explained a typical well day living with the disease.

Each day starts with a two-hour process of medications, hydration, breathing treatments and chest physical therapy, followed by sterilization of all equipment.He takes an additional round of medication at lunchtime and repeats the process again after dinner.

No two days are alike, said Cobb. One day, my family is on standby to see if Ill be admitted to the hospital. Another day, I could help you dig a ditch in the front yard.

Because there are different mutations of CF, typical days and treatment types vary for each person.CF often results in hospitalization for infection.

Modulators, which target the defective gene that causes CF, are the newest treatment option, and hopefully will soon be available to almost 90 percent of those living with CF.

Treatment is geared toward the mutation a patient has, said Elaine Chambless, Senior Director of Development for the Cystic Fibrosis Foundations Alabama chapter. It helps correct the gene thats malfunctioning.

Much of the research goes on in Birmingham at UAB. UAB is home to the Gregory Fleming James Cystic Fibrosis Research Center, which has a clinic for CF patients in addition to research facilities. The center, led by Dr. Steven Rowe, sees about 400 CF patients each year.

Cobb, who lives in Heflin, Alabama, explained that having a CF clinic close to home makes a huge impact. It can be the difference between life and death, he said.

Consider getting involved with the Alabama Chapter of the Cystic Fibrosis Foundation in Birmingham. Their 14th annual sporting clays competition, Shoot for a Cure, is happening on October 11 at Selwood Farm beginning at 8:00 a.m. Buy tickets here.

Cystic Fibrosis Foundation board member and sporting clays event chair, Joel Barber of Vulcan Materials Company, said he decided to get involved with the foundation after a friends child was diagnosed with CF. Since then, Ive tried to do everything I can to add days, weeks and total lifespans to people living with CF, he said.

With connections in the construction and mining industry and dedication to the CF Foundation, Barber, fellow Vulcan employees and CF Foundation staff rally each year to secure sponsorships and participants who are interested in joining forces to help in the fight against CF.

The shoot provides a great networking opportunity for those in the industry and a great way for everyone to help raise funds for the important research going on in Alabama, he said. The sporting clays event has grown each yearlast years event raised just over $100,000.

If you cant make the sporting clays shoot, there is also a Birminghams Finest event for young professionals. Its a competition to see who can raise the most money for the CF Foundation, and fundraising rock stars will be recognized at an event on November 21 in downtown Birmingham.

As treatments continue to be refined, CF patients will be able to live longer lives. If we get kids on the modulators when theyre little, before theres any damage done, they will get to grow old, said Cobb. Theres a lot of hope.

Interested in learning more about CF or the work of the Cystic Fibrosis Foundation? Visit their website.

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KBRA Assigns Preliminary Ratings to CF 2019-CF2 – Yahoo Finance

Posted: at 3:45 am

NEW YORK--(BUSINESS WIRE)--

Kroll Bond Rating Agency (KBRA) is pleased to announce the assignment of preliminary ratings to 18 classes of CF 2019-CF2 (see ratings list below), a $802.9 million CMBS conduit transaction collateralized by 48 commercial mortgage loans secured by 136 properties.

The collateral properties are located in 26 states, with the top three states represented by Florida (11.9%), New York (11.5%), and California (10.9%). The pool has exposure to all the major property types, with the top three being retail (19.9%), multifamily (18.6%), and office (16.5%). The loans have principal balances ranging from $3.0 million to $68.0 million for the largest loan in the pool, GNL Office and Industrial Portfolio (8.5%), which is secured by 12 single-tenant industrial and office properties located in 10 states that together comprise 2.2 million sf. The five largest loans, which also include Uline Arena (5.2%), Ocean Edge Resort & Golf Club (5.0%), Inland Life Storage Portfolio (4.9%) and Bushwick Avenue Portfolio (4.5%), represent 28.1% of the initial pool balance, while the top 10 loans represent 46.8%.

KBRAs analysis of the transaction incorporated our multi-borrower rating process that begins with our analysts' evaluation of the underlying collateral properties' financial and operating performance, which determine KBRAs estimate of sustainable net cash flow (KNCF) and KBRA value using our U.S. CMBS Property Evaluation Methodology. On an aggregate basis, KNCF was 7.1% less than the issuer cash flow. KBRA capitalization rates were applied to each assets KNCF to derive values that were, on an aggregate basis, 42.5% less than third party appraisal values. The pool has an in-trust KLTV of 99.4% and an all-in KLTV of 106.4%. The model deploys rent and occupancy stresses, probability of default regressions, and loss given default calculations to determine losses for each collateral loan that are then used to assign our credit ratings.

For complete details on the analysis, please see our pre-sale report published at http://www.kbra.com. The preliminary ratings are based on information known to KBRA at the time of this publication. Information received subsequent to this release could result in the assignment of ratings that differ from the preliminary ratings.

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Preliminary Ratings Assigned: CF 2019-CF2

Class

Initial Class Balance

Expected KBRA Rating

A-1

$20,649,000

AAA (sf)

A-2

$40,987,000

AAA (sf)

A-SB

$28,718,000

AAA (sf)

A-3

$39,556,500

AAA (sf)

A-4

$100,000,000 - $214,000,000

AAA (sf)

A-5

$218,123,500 - $332,123,500

AAA (sf)

A-S

$67,243,000

AAA (sf)

B

$36,131,000

AA+ (sf)

C

$37,134,000

A (sf)

D

$24,087,000

BBB+(sf)

E

$18,066,000

BBB (sf)

F

$19,069,000

BB (sf)

G

$8,029,000

B+ (sf)

NR-RR

$31,113,052

NR

X-A

$562,034,000

AAA (sf)

X-B

$140,508,000

AAA (sf)

X-D

$42,153,000

BBB (sf)

X-F

$19,069,000

BB (sf)

X-G

$8,029,000

B+ (sf)

Loan-Specific Certificates3

SWA

$5,130,000

NR

SWB

$5,070,000

NR

SWC

$5,890,000

NR

SWD

$6,190,000

NR

SWE

$5,620,000 - $5,820,0004

NR

SWRR

$1,900,000 - $2,100,0004

NR

SWX1

$10,200,000

NR

SWX2

$12,080,000

NR

1 The exact initial certificate balances will not be determined until final pricing, however, they are expected to fall within the above ranges; the aggregate initial certificate balance of the Class A-4 and Class A-5 certificates is expected to be approximately $431.1 million. 2 Notional balance. 3 Loan-specific certificates are only entitled to amounts received with respect to The Stanwix Subordinate Companion Loan. 4 The exact initial certificate balances will not be determined until final pricing, however, they are expected to fall within the above ranges; the aggregate initial certificate balance of the SWE and SWRR certificates is expected to be approximately $7.2 million.

To access ratings, reports and disclosures, click here.

Related Publications: (available at http://www.kbra.com)

CONNECT WITH KBRA

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About KBRA and KBRA Europe

KBRA is a full-service credit rating agency registered with the U.S. Securities and Exchange Commission as an NRSRO. In addition, KBRA is designated as a designated rating organization by the Ontario Securities Commission for issuers of asset-backed securities to file a short form prospectus or shelf prospectus. KBRA is also recognized by the National Association of Insurance Commissioners as a Credit Rating Provider, and is a certified Credit Rating Agency (CRA) by the European Securities and Markets Authority (ESMA). Kroll Bond Rating Agency Europe Limited is registered with ESMA as a CRA.

View source version on businesswire.com: https://www.businesswire.com/news/home/20190919005561/en/

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KBRA Assigns Preliminary Ratings to CF 2019-CF2 - Yahoo Finance

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CF Industries (CF) Shares Rise 22% in 6 Months: Here’s Why – Yahoo Finance

Posted: at 3:45 am

Shares of CF Industries Holdings, Inc. CF have gained 21.8% in the past six months. The stock has outperformed the industrys decline of 5.6% over the same time frame.

CF Industries has a market cap of around $11.1 billion. Average volume of shares traded in the past three months was around 2,253.4K. The company has expected long-term earnings per share (EPS) growth rate of 6%.

Factors Driving the Rally

Better-than-expected second-quarter 2019 results as well as upbeat view for 2019 are contributing to the rally in the companys shares.

In the second quarter, the companys adjusted EPS rose more than two-fold year over year to $1.28. The figure also surpassed the Zacks Consensus Estimate of 81 cents.

Net sales rose 15.5% year over year to $1,502 million on the back of higher average selling prices across all major products. It also topped the Zacks Consensus Estimate of $1,373 million.

CF Industries is optimistic about the nitrogen fertilizer industry and expects fundamental factors to be positive in the near and the long term.

The company expects demand for nitrogen in North America to remain strong in the near term, driven by the impact of adverse planting and growing conditions in many parts of the United States in 2019. Historic flooding is expected to reduce corn production in 2019 due to considerably lower planted acres and yields. The company expects these factors to create a strong price incentive for farmers in the United States, which will boost planted corn acres considerably in the next two seasons.

Globally, demand for urea from Brazil and India are expected to stay strong over the next two years. Through the end of June 2019, urea imports to India were 3.5 million metric tons, up 11% year over year, as stated by the company. Moreover, urea imports to Brazil for 2019 are expected to rise.

CF Industries Holdings, Inc. Price and Consensus

CF Industries Holdings, Inc. Price and Consensus

CF Industries Holdings, Inc. price-consensus-chart | CF Industries Holdings, Inc. Quote

Zacks Rank & Key Picks

CF Industries currently carries a Zacks Rank #3 (Hold).

Some better-ranked stocks in the basic materials space are Kinross Gold Corporation KGC, Alamos Gold Inc AGI and Arconic Inc ARNC, all sporting a Zacks Rank #1 (Strong Buy). You can seethe complete list of todays Zacks #1 Rank stocks here.

Kinross has an expected earnings growth rate of 160% for 2019. The companys shares have surged 66.8% in the past year.

Alamos Gold has projected earnings growth rate of 320% for the current year. The companys shares have rallied 33.6% in a years time.

Arconic has an estimated earnings growth rate of 50% for the current year. Its shares have moved up 20.9% in the past year.

5 Stocks Set to Double

Each was hand-picked by a Zacks expert as the #1 favorite stock to gain +100% or more in 2020. Each comes from a different sector and has unique qualities and catalysts that could fuel exceptional growth.

Most of the stocks in this report are flying under Wall Street radar, which provides a great opportunity to get in on the ground floor.

Today, See These 5 Potential Home Runs >>

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free reportCF Industries Holdings, Inc. (CF) : Free Stock Analysis ReportAlamos Gold Inc. (AGI) : Free Stock Analysis ReportKinross Gold Corporation (KGC) : Free Stock Analysis ReportArconic Inc. (ARNC) : Free Stock Analysis ReportTo read this article on Zacks.com click here.Zacks Investment Research

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CF Industries (CF) Shares Rise 22% in 6 Months: Here's Why - Yahoo Finance

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Lauren Albright: She tackles work, and Cystic Fibrosis, with positivity – Lehigh Valley Business

Posted: at 3:45 am

An old adage says business and family dont mix well. Dont tell that to Lauren Albright. At just 27 years old, she is a key player in her familys successful business, Creative Tile Imports in Allentown.

Laurens father, Albert, and grandfather, Albert, Sr., started Creative Tile as a small family business in 1999. Today, Creative Tile has a busy 5,000-square-foot showroom and customers from around the country.

And Lauren, whose grandfather passed away in 2004, joined the company in 2013 and is now part owner of this family legacy, along with her mother Jane and father. Her sister, Olivia, is also part of the business.

Despite the challenges that come with working alongside her parents and sibling, Lauren wouldnt have it any other way.

Lauren Albright, part owner of her familys business, Creative Tile Imports in Allentown, with her dog, Roux submitted

I love it, she says, I really do.

Her job is demanding; there are design consults, international orders to be placed and staff to manage. But, what few Creative Tile customers know is that Lauren also faces the demands of a chronic, life-long illness called Cystic Fibrosis.

An inherited disorder that damages the lungs and digestive system, the disease affects the cells that produce mucus, sweat, and digestive fluids, leaving them prone to infection. She was diagnosed with CF as an infant. But Lauren has survived and thrived in the face of what can sometimes be a terminal diagnosis.

LVB wanted to find out more about this hard-working young woman, and how she successfully juggles the many needs of her health, her career and her tight family life.

Heres how she does it.

You werent always interested in becoming part of the family business. Tell us what you did before coming on board at Creative Tile?

I went to culinary school after high school. After graduating from the Culinary Institute of America, I started a food truck with my sister, Olivia. It was a pie truck, called Sweet and Savory Pies.

We both had to work other jobs in addition to the food truck to get by. I started working with my family. My sister was working at WFMZ-TV. The food truck hours were so crazy, and we both found that we were finding real fulfillment in our other jobs. So we decided to let go of the food truck and I made the family business my focus.

If you had told me as a teenager that I would be working here full time one day, I wouldnt have believed you. But I love it.

As a young woman in a somewhat male dominated tile industry, have you experienced any sexism?

I have experienced some doubt in my abilities by certain contractors. They may have been doing this for 60 years and can be reluctant to believe that the girls know what they are doing. They will call and ask for one of the men. I assure them that we girls know the answers, we really do.

What do you find most challenging and conversely, most rewarding, about managing the family business?

Just the day-to-day work is challenging. We are always trying to get bigger and expand, and Im always trying to keep our staff motivated to keep growing. We have a fantastic staff so they dont need a lot of motivation. We do things like have company get togethers to keep the staffs morale high.

Half of the staff is related to each other, and the others, well, we like to say they are family, too. We want to make sure that everyone is enjoying their job, that they are challenged and happy.

Most rewarding? For me, bringing in new business is an accomplishment and exciting. I love sales.

What is it like to work with your family; to be together all the time?

For me, its great. Family can always be a challenge but I think its challenging to work with any people regardless. But you know these people so well, youve already been working with them for so long, it works. It can be emotional, however. You can feel personally offended by things that you might not from someone you are not related to. We can butt heads from time to time but my mom tends to be a good conflict resolver.

When you arent working, do you try and spend time away from your family to get a little needed space?

No, we actually spend a lot of time together outside of the business, too. We have family dinner every Sunday. We work out together two or three times a week. Family is what we do.

In addition to work, Cystic Fibrosis is a part of your life, too. What do you need to do daily to manage your health?

I have to do two treatments every day, at least: two nebulizer breathing treatments, and then I have to wear this thing called the vest, which shakes you for 20 minutes (to loosen the mucus). Its definitely an added thing to my day. I probably spend an hour and a half on treatments every day.

I used to skip treatments sometimes in high school, but Ive become better at it and more responsible with it as Ive gotten older. I realize how important it is to my health. I work out, in part because it helps you cough. Anything that helps you cough is encouraged.

Have your methods of treatment changed over the years?

Definitely. I need to be better about treatments now. As you get older, your lungs get more scarred from infections from over the years. But now Im part of an experimental treatment for a drug that was just sent for FDA approval. Its been incredible. Its raising peoples lung function.

People are living a lot longer today. They are making a lot of strides. The CF foundation is really good at finding effective medications.

Is CF something that is passed down from your parents?

Lauren Albright, pictured on left, with her family-father Albert, mother Jane, and sister Olivia, outside their family business, Creative Tile Imports in Allentown submitted

Yes, it is genetic. One in 30 Caucasians is a carrier. My sister is a carrier. I have it. My parents are both carriers. Your parents both have to be carriers for you to get it.

My sisters husband is not a carrier, so her kids do not have it.

I will pass on the gene, and my husband is a carrier, but with a more-mild gene, that doesnt always develop CF.

Its a complicated and rare disease, so no one can give you an exact answer on if your child will develop it.

Are customers at work aware that you have CF?

No, I dont really mention it. However I have been on I.V.s before, and have had to do them here. You cant really hide that.

Outside of your hour and a half treatment, is having CF on your mind during the day?

Yes, I used to work even longer crazier hours here, and then one year I got double pneumonia and didnt even know. I thought I just had a cold. I realized I needed to work regular hours, fit in exercise, treatments and rest times.

I feel like I made a life adjustment when I got double pneumonia. I have to deal with this. Its always on your mind. Even every time I eat, its on my mind because I have to take pills to digest my food.

Do the majority of people with CF also work full time?

Lots of people with CF are working full time, but its individual. It depends on your genetics and which infections you have had. Some people are getting double lung transplants in their 20s.

Every year the life expectancy goes up. When I was born, the life expectancy was in your 20s, now its close to 40. There are people living into their 90s. It depends on your case.

I have moderate CF. It worsens as you get older, but because Im on this drug, Ive had significant improvement. Very noticeable improvement.

This drug is to be taken every day, twice a day, and is pretty revolutionary.

Do you think most people with chronic illnesses are afraid to mention it when they apply for jobs? Afraid it might effect if they get hired or not?

It is something CF people worry about a lot. You might not mention it if you were looking to get hired, but at the same time, you can get infections easier, so you would eventually have to tell your employer.

Insurance is a concern as well with CF. I believe in universal health care. If you dont have insurance coverage with CF, I dont know what you would do. Im sure my drugs cost $15,000 a month if not more.

Are you concerned about what might happen with your health 10 years down the road- with work, with family?

The plan is for me to take over the business, but there is always the question of How will my health be?

But 10 years ago I never would have thought I would be on this life changing new drug. What else will come out that is life changing? Its an unpredictable disease. Its hard.

How do you maintain the balance between being an ambitious professional and maintaining your health?

Its hard and Im still learning. I constantly push myself too much, and I notice it and get myself back on track. Health has to be your first focus. You have to be healthy in order to come to work.

Do you ever feel like: Why is this happening to me? How do you get through that?

Of course, especially when I get sick. You have to get over it. There is nowhere to go with it. It wont help you. And at the same time, CF has definitely shaped who I am. I have matured faster. I have had to take on responsibility at a young age.

My disease was mine to handle myself. Im not overwhelmed as much by other things. Ive learned to manage and take on challenging things more easily than others might. For example, I take the responsibility of being given the opportunity to work in this family business very seriously. I never want to be a noose around its neck.

And its exciting to feel passionate about your work. In general, its a great feeling to be so invested in something.

Do you have any advice for other young women starting out in business who may be facing their own hidden challenges?

The biggest key is to believe in yourself. If you are doubting yourself, it shows. You have as much value as any one. You are capable. Feel confident in what you are doing. Thats how you succeed.

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Lauren Albright: She tackles work, and Cystic Fibrosis, with positivity - Lehigh Valley Business

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Scottish Health Insurance System to Cover Orkambi, Symkevi for CF – Cystic Fibrosis News Today

Posted: at 3:45 am

A new agreement will give people in Scotland with cystic fibrosis access to the CF combination treatments Orkambi (lumacaftor/ivacaftor) and Symkevi (tezacaftor/ivacaftor) through the countrys health system, according to Vertex Pharmaceuticals, the company that sells both medicines.

The announcement follows a prior rejection by theScottish Medicines Consortium (SMC) in August, in which the agency cited concerns that the cost of the treatments was not proportional to their health benefits.

Despite that first negative outcome, Vertex continued its efforts to ensure patient access through the health insurance system to the two approved therapies. The company has now reached a five-year agreement with SMC.

In addition to giving Scottish people with CF access to Orkambi and Symkevi at little or no cost, the agreement stipulates that Vertex will collect real-world data on the use of these medicines. That data should be used to support any future submissions to the SMC, the agency said.

We would like to thank the Scottish authorities for their partnership and the collaborative and flexible way that we have worked together to find this access solution, Ludovic Fenaux, senior vice president of Vertex International, said in a press release. It means that approximately 400 eligible cystic fibrosis patients in Scotland now have access to Orkambi or Symkevi.

Both Orkambi and Symkevi work by addressing the cause of CF, which is the lack of a working CFTR protein. The cystic fibrosis transmembrane conductance regulator (CFTR) protein helps to maintain the balance of salt and water on many surfaces in the body, such as the surface of the lungs. These medicines employ a one-two punch of getting the CFTR properly processed and placed where it is supposed to go, then keeping it stable and functioning properly once it is there.

Orkambi is specifically designed to reverse the effects of the most common CF mutation, the F508delmutation. Symkevi, known asSymdeko outside the E.U., is not specific to a particular CF-causing mutation. However, the tezacaftor/ivacaftor combination is designed to restore the CTFR proteins function.

Both therapies contain ivacaftor sold alone under the brand name Kalydeco which helps stabilize the CFTR protein once it is at the surface of cells. The other components lumacaftor in Orkambi and tezacaftor in Symkevi are responsible for ensuring the correct folding of CFTR.

NHS Scotland estimates that about 900 people in Scotland have CF, and as many as 1 in 24 carry one mutation in the gene encoding CFTR.

Vertex CF medicines are currently reimbursed in 17 countries globally, including Austria, Australia, Denmark, Germany, the Republic of Ireland, Italy, the Netherlands and Sweden.

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Scottish Health Insurance System to Cover Orkambi, Symkevi for CF - Cystic Fibrosis News Today

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CF school building projects making progress | Local News – Leader-Telegram

Posted: at 3:45 am

Building projects at three locations in the Chippewa Falls school district are progressing nicely, Business Manager Chad Trowbridge told the school board Tuesday night.

The structure for the new Stillson Elementary school in Lafayette is set, concrete pours are beginning, and brick and exterior fences will begin to be put up within the next month.

At the middle school, workers are starting construction on the roof this week, a new bus loop is being used, site restoration is complete and the interior is being worked on consistently.

At Chippewa Falls High School, work is underway on construction on the second floor, roof installation will be completed over the next few weeks and interior walls are being put up.

Trowbridge said significant progress has been made in the past month at all three locations.

Its been an exciting month, to put it mildly, Trowbridge said. As far as Im concerned, we are making good progress and we are on a good pace. Knock on wood we may be even be a little ahead of schedule. We are pleased with the progress so far.

John Dienger, student representative on the Chippewa Falls school board and a senior at Chippewa Falls High School, said he hasnt heard many students or staff complain about the construction in the three weeks since classes started. He said original concerns such as lack of parking and late arrival at school have been alleviated by earlier arrival times and adaptation to the different landscape at the middle and high school.

In early 2018, a $65 million referendum was approved with 53 percent voter approval to build a new home for Stillson Elementary and make additions and improvements to the existing middle and high school structures.

The building project includes a new 36-acre site in the town of Lafayette, a drastic increase from the current six-acre site. The 30-acre increase will yield more space for a parking lot, playground, athletic fields and more.

The rest of the funds will be used at the middle and high schools. The middle school will use the allocated funds to remodel areas of the building, improve technology and make other upgrades and repairs. The high school will get a new science lab, improved technology and other improvements.

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CF school building projects making progress | Local News - Leader-Telegram

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CF woman charged with making false 911 call | Local News – Leader-Telegram

Posted: at 3:45 am

CHIPPEWA FALLS A Chippewa Falls woman has been charged with making a false 911 report, after she claimed someone was threatening another person with a gun.

Shahannah A. Barnes, 28, 820 Macomber St., was charged with second-degree recklessly endangering safety, making a false 911 report and disorderly conduct.

According to the criminal complaint, the incident happened on Aug. 8 at the apartment complexes in the 800 block of Macomber Street. A woman who turned out to be Barnes told a dispatcher that she could hear a woman yelling for help, and the woman was asking someone to put a weapon down.

Because of the serious nature of the call, officers approached with their guns drawn. However, the man and woman at the apartment claimed there had been no incident at all.

When police looked at who made the call, it was a phone belonging to the man in the apartment. However, the man said his girlfriend, Barnes, had his phone. He admitted he was cheating on Barnes with the woman in the apartment.

When police interviewed Barnes, she admitted she made the false 911 call.

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CF woman charged with making false 911 call | Local News - Leader-Telegram

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