Daily Archives: August 15, 2017

Lungs in space: research project could lead to new lung therapeutics – Phys.Org

Posted: August 15, 2017 at 12:32 pm

August 15, 2017

Space travel can cause a lot of stress on the human body as the change in gravity, radiation and other factors creates a hostile environment. While much is known about how different parts of the body react in space, how lungs are affected by spaceflight has received little attention until now, say researchers at The University of Texas Medical Branch at Galveston and Houston Methodist Research Institute.

That will change, though, once their research project, which aims to grow lungs in space, reaches the International Space Station. UTMB and HMRI researchers say what they learn from the study could have real implications for astronauts, as well as those still on Earth, and could lead to future therapeutics.

"We know a lot about what happens in space to bones, muscle, the heart and the immune system, but nobody knows much about what happens to the lungs," said Joan Nichols, a professor of Internal Medicine and Microbiology and Immunology, and associate director for research and operations for the Galveston National Laboratory at UTMB. "We know that there are some problems with lungs in space flight, but that hasn't been closely looked into. We hope to find out how lung cells react to the change in gravity and the extreme space environment, and then that can help us protect astronauts in space, as well as the lungs of regular people here on Earth."

This investigation represents the third of four collaborative projects currently active at the HMRI's Center for Space Nanomedicine. The center, directed by Alessandro Grattoni, chairman and associate professor of the Department of Nanomedicine at HMRI, focuses on the investigation of nanotechnology-based strategies for medicine on Earth and in space. The research is supported by the Center for the Advancement of Science in Space, NASA and HMRI.

Scientists from UTMB and HMRI prepared bioreactor pouches that include lung progenitor and stem cells and pieces of lung scaffolding. The scaffolding is the collagen and elastin frame on which lung cells grow. Space X successfully launched the payload containing these pouches Aug. 14 on its 12th Commercial Resupply Services mission (CRS-12) from NASA's Kennedy Space Center in Florida and is expected to arrive at the International Space Station Aug. 16. Once on the ISS, the cells are expected to grow on the scaffold in a retrofitted bioreactor.

Once the lung cells have returned to Earth, researchers will look for the development of fibrosis, the structure of the tissues and the response of immune cells, among other changes and damage that could occur to the lung cells. Lung injuries have been found to accelerate in space, and it is through close study of those cells that therapeutics hopefully could be developed.

Nichols and Dr. Joaquin Cortiella, a professor and director of the Lab of Tissue Engineering and Organ Regeneration at UTMB, have successfully grown lungs in their lab in Galveston, but now they will see if astronauts can do the same in zero gravity. Jason Sakamoto, affiliate professor and former co-chair of the Department of Nanomedicine at HMRI, has applied his novel organ decellularization process and nanotechnology-based delivery systems to support this overall lung regeneration effort.

"We have experience working with the Center for the Advancement of Science in Space to study our nanotechnologies in action on the International Space Station," Grattoni said. "However, we are extremely excited to be a part of this clinical study, since it may play a pivotal role in how we approach future space travel in terms of preserving astronaut health. What we learn during this fundamental experiment could lead to science-fiction-like medical advancements, where organ regeneration becomes a reality in both deep space and here on Earth."

Researchers at HMRI will take the results from UTMB and work on developing therapeutics that could help astronauts, as well as people on Earth.

"This exploration will provide fundamental insight for the collaborative development of cell-based therapies for autoimmune diseases, hormone deficiencies and other issues," Grattoni said.

Explore further: Image: Testing astronauts' lung health

The stellar views from the International Space Station are not the only things to take an astronaut's breath away: devices like this are measuring astronauts' breath to determine the health of their lungs. ESA astronaut ...

Astronauts in space are valuable sources of scientific data. Researchers collect blood and urine samples to understand what effects living in weightlessness has on their bodies. For one experiment, investigators are interested ...

A wide variety of research relies on growing cells in culture on Earth, but handling these cells is challenging. With better techniques, scientists hope to reduce loss of cells from culture media, create cultures in specific ...

In a US presidential election that's already been out of this world, the lone American astronaut in outer space has cast his vote, NASA said Monday.

Astronauts on Chinese space station Tiangong-2 greet ESA and Thomas Pesquet. This video was recorded inside the Chinese space station Tiangong-2 by astronauts Jing Haipeng and Chen Dong. The duo landed safely on Earth on ...

Abba Zubair, M.D., Ph.D, believes that cells grown in the International Space Station (ISS) could help patients recover from a stroke, and that it may even be possible to generate human tissues and organs in space. He just ...

Venus looks bland and featureless in visible light, but change the filter to ultraviolet, and Earth's twin suddenly looks like a different planet. Dark and light areas stripe the sphere, indicating that something is absorbing ...

The cosmic webthe distribution of matter on the largest scales in the universehas usually been defined through the distribution of galaxies. Now, a new study by a team of astronomers from France, Israel and Hawaii demonstrates ...

Ten spacecraft, from ESA's Venus Express to NASA's Voyager-2, felt the effect of a solar eruption as it washed through the solar system while three other satellites watched, providing a unique perspective on this space weather ...

Even tiny dust particles have stories to tell especially when they come from outer space. Meteorites contain tiny amounts of what is popularly known as stardust, matter originating from dying stars. Such stardust is part ...

Many exoplanets to be found by coming high-powered telescopes will probably be tidally lockedwith one side permanently facing their host staraccording to new research by astronomer Rory Barnes of the University of Washington.

A team of astronomers led by William Dixon of the Space Telescope Science Institute in Baltimore, Maryland, has presented new spectral analysis of the ultraviolet-bright star Y453. The study, presented Aug. 3 in a paper published ...

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

See the article here:

Lungs in space: research project could lead to new lung therapeutics - Phys.Org

Posted in Space Travel | Comments Off on Lungs in space: research project could lead to new lung therapeutics – Phys.Org

Big Free Update For PC RTS Ashes Of The Singularity: Escalation Detailed – GameSpot

Posted: at 12:31 pm

Subscribe for the latest gaming news

A big patch and free DLC are on the way to Ashes of the Singularity: Escalation, developer Stardock announced today. The 2.4 update arrives next week.

2.4 improves and addresses a huge number of areas. The menus and UI have been reworked, difficulty has been adjusted for all three campaigns and certain scenarios, and modders gain access to more areas of the game. Brand-new in this update is Vulkan support, which Stardock says should improve both "OS compatibility and performance."

There are also numerous balance changes to air, anti-air, drone, and dreadnought units, with the goal being to "improve strategic diversity." Additionally, the Substrate has seen unspecified changes meant to help distinguish it from the PHC.

Alongside the 2.4 update, Stardock will release a free DLC pack with nine new maps that are "designed for cooperative play." Teammates' spawn points will be located closer together, and each will have their own "clearly defined" set of resources, which should prevent them from having to compete with each other.

Both the free co-op DLC and update 2.4 are planned for release on August 24.

Read the rest here:

Big Free Update For PC RTS Ashes Of The Singularity: Escalation Detailed - GameSpot

Posted in Singularity | Comments Off on Big Free Update For PC RTS Ashes Of The Singularity: Escalation Detailed – GameSpot

Space exploration will send our economy into orbit – The National

Posted: at 12:28 pm

Alia Al Mansoori is a fine example of how space research can galvanise young minds. Scott A Miller / The National

At precisely 12.31pm on Monday, a Falcon9 rocket lifted off from Nasas Kennedy Space Centre in Florida. The rocket shot a 2,900 kg Dragon cargo capsule into space. When astronauts aboard the International Space Station retrieve the capsule today, they will find, among its contents, an experiment by Emirati teenager Alia Al Mansoori that will study DNA to identity how proteins in living organisms are synthesised, modified and regulated in space. The results of the experiment may yield clues that could aid in the prevention of unwanted cell death in astronauts on long-haul missions into deep space, including future flights to Mars. Ms Al Mansooris experiment won the Genes in Space competition, which is sponsored by The National, the UAE Space Agency and Boeing. She is the first winner from outside the United States.

The inclusion of Ms Al Mansooris experiment in the Nasa mission is a measure of the strides the UAE has made since Sheikh Zayedquizzed visiting American astronauts in the 1970s about space exploration. In 2014, the UAE launched its own Space Agency, the first in the Arab world. In 2020, the agency will launch space probe that will reach Mars the following year, coinciding with the 50th anniversary of the UAEs founding. In 2015, the UAE established the Mohammed bin Rashid Space Centre. Two years later, Sheikh Mohammed bin Rashid, Vice President and Ruler of Dubai, unveiled the Mars 2117 Project: a plan to buildthe first human settlement on Mars within a century. "Nothing is impossible ... we can compete with the greatest of nations in the race for knowledge," he said when he announced the project earlier this year.

The UAEs space programme drew sceptical responses from some quarters in the beginning. To others, space exploration has always seemed like a waste of resources. This is a profoundly misplaced view. Ms Al Mansoori is a fine example of how space research can galvanise young minds. It is a catalyst for technological innovations; in addition to making hugely important discoveries in space, it gives rise to unexpected inventions on earth that benefit us all. John FKennedy understood this; as, in our own day, does Sheikh Mohammed.

The computer microchip, the CAT scanner (which can detect cancer), the satellite television and the smoke detector these are all among the dozens of technologies we now take for granted but which would not be available to us were it not for space research. As Dr Ahmad Belhoul, the UAEs Minister of State for Higher Education and the Chairman of the UAE Space Agency, wrote in these pages last month, space exploration is a necessity not only because of its tangible benefits to our everyday lives, but because of its potential to inspire and uplift mankind in ways we can only imagine.It will, in short, drive the knowledge economy and ensure that our post-oil economy receives a necessary boost of rocket fuel.

Read the original here:

Space exploration will send our economy into orbit - The National

Posted in Space Exploration | Comments Off on Space exploration will send our economy into orbit – The National

Chris Hadfield: Space exploration is an example for the world to look up to – iNews

Posted: at 12:28 pm

At a time when the world is increasingly isolationist, astronaut Chris Hadfield believes space exploration can demonstrate the importance ofinternational co-operation.

Speaking to i, as the war of words between North Korea and the United States escalates, Commander Hadfield described the International Space Station (ISS) as an undeniable example of what we can do together.

Talking ahead of his BBC series Astronauts: Do you have what it takes?, the 57-year-old Canadian accepted that it was natural for world leaders to have disagreements.

I think that world leaders should be at each others throats because they have national agendas that they have been elected or anointed to defend and its understandable.

It is very much the responsibility of the people in charge to defend the interests of their subjects and there is nothing wrong with that thats normal.

However, for leaders actions to be meaningful, Hadfield believes that they must focus on the longer term.

For world leaders to do anything thats beyond a myopic job or for them to be a good leader they have to gather the knowledge and perspective that is beyond the short term exigencies and demands.

If all youre trying to do is get dinner on the table tonight, then you might make some terrible decisions about what everyone is going to eat tomorrow or next week.

Or if you say the only people in the world that matter are this little pocket of people right here, you might save the lives of that little pocket, but you may horribly affect the lives of so many more people that youre completely unaware of.

Hadfield, who took part in two space shuttle missions and was commander of the International Space Station, outlined the political lessons that can be learned from space exploration.

I think the lessons that come from exploration of our world and beyond is a much improved understanding of that perspective that the world is one shared place.

If you can go round the world in 92 minutes, its very difficult to go back to your tiny little patch of it without a different understanding, without a different perspective, and I think that ability to find a way to set an agenda that is beyond the myopic, beyond the extremely parochial, thats the example that the ISS sets.

Hadfield believes that the ISS can act as inspiration for children and world leaders alike.

Any kid on earth can walk out and if they just wait till the right time, dawn or dusk, and see this thing [the ISS] go over.It is the brightest star in the sky.

It is by no means the answer to everything, but it is a very clear, undeniable example of what we can do together when we do things right.

I think that type of example is a really worthwhile one to have right now, especially for the people who are most at each others throats.

Since its first residents moved in 17 years ago, nationals of 18 different countries have stepped on board the ISS.

The 420,000 kilogram structure is currently inhabited by three Americans, two Russians and an Italian.

More:What it takes to be an astronaut according to Chris Hadfield

Read more:

Chris Hadfield: Space exploration is an example for the world to look up to - iNews

Posted in Space Exploration | Comments Off on Chris Hadfield: Space exploration is an example for the world to look up to – iNews

One Year Later, No Man’s Skyand Its EvolutionIs Worth Exploring – WIRED

Posted: at 12:28 pm

No Man's Sky promised infinity, and that's a promise nothing can ever keep.

You may remember that Hello Games' epic space exploration opus landed one year ago. In the months preceding its release, the game became a sensation based solely on word of mouth. Studio lead Sean Murray appeared on Late Night With Stephen Colbert . The technology behind the game garnered breathless coverage in The New Yorker and every gaming publication. Fans buzzed with anticipation.

No Man's Sky promised a galaxy of infinite, procedurally generated planets to explorea rich microcosm of life to catalog and experience. It became, in the imaginations of many players, a sort of final game , the end product of digital entertainment that you could live in indefinitely.

Julie Muncy

This Game Isnt Just MetalIts a Horror Treasure

Julie Muncy

The Long Dark: a Game Tailored for the Age of Climate Anxiety

Julie Muncy

Tacoma Is a Compelling Game, But It Cant Top Gone Home

Naturally, that didn't happen. Turns out, Murray created just another videogameand a quiet one at that. You spent very little time interacting with anything other than a vast, open void. You flew to a planet and gathered the resources needed to fly to another one. You did this over and over and over until you reach the center of the galaxy or until you grew bored. An exile in deep space. The massive hype quickly gave way to an equally massive backlash. Players were horrified. The subreddit built around the game experienced a minor meltdown. Even now, No Man's Sky remains one of the few highly anticipated major releases on Steam with "mostly negative" reviews.

To mark the game's first anniversary, Hello Games just released a major update. In doing so, it underscores not just gaming's newfound plasticity, but the redemption that can be found within it.

"Atlas Rises" is the third update since the game's release, and it feels fundamentally different. It adds a few things players have griped about for ages, like the ability to fly close to the ground or summon your ship from anywhere, but it is ambitious enough be more than a sop to the few faithful fans. By adding 30 hours of story to the game, the update fleshes out a more complex narrative. By allowing players to communicate with others in their vicinity, it lays a foundation for cooperative play in the future. The patch notes drone on and onnew quest system, improved trade, more robust visual interfacesbut taken together they take on a new shape. Hello Games makes an overture to everyone who wrote off the game a week after launch. No Man's Sky is still here, the update says, and it is a growing thing. Hello Games would prefer you not abandon it so quickly.

In 2017, games like No Man's Sky can evolve over time, building and rebuilding audiences during their lifespans. They can flirt, woo, and make overtures to lost loves.

Thus is the state of play in 2017. Far from being mere glitch fixes, enhancements, or monetization plays , post-release patches turn games into organic texts. They make artistic work explicitly conversational, a dialogue between creator and audience in which players' responses can drastically shape, and reshape, a product. That doesn't always lead to a positive outcomeit can create a sense of entitlement among players, and perhaps even lead to harassmentbut it lets games like No Man's Sky evolve over time, building and rebuilding audiences during their lifespans. They can flirt, woo, and make overtures to lost loves.

Setting aside the merits of any features Hello Games added or removed since the game's release, it's worth remembering what made No Man's Sky so remarkable to begin with: It presented enormity as meditation. It is a game so big, so full of cosmic spectacle, and so dedicated to showcasing the powerful, eclipsing emptiness of space that playing it could verge on a spiritual practice. This was a game to be played slowly, thoughtfully, with curiosity and reverential care.

That game is still there for anyone willing to give it a chance. It might be bigger and a bit more conventional now, but no matter. Its galaxies are worth exploring.

Read more:

One Year Later, No Man's Skyand Its EvolutionIs Worth Exploring - WIRED

Posted in Space Exploration | Comments Off on One Year Later, No Man’s Skyand Its EvolutionIs Worth Exploring – WIRED

SpaceX to launch supercomputer to International Space Station – WGN-TV

Posted: at 12:28 pm

TITUSVILLE, Fla. A SpaceX rocket is ready to deliver one of the most high-tech payloads ever to the International Space Station.

The launch is scheduled for 12:31 p.m. ET. on Monday from NASAs Kennedy Space Center in Florida.

It marks the 12th unmanned resupply mission that SpaceX the private space exploration company headed by Tesla CEO Elon Musk has conducted for NASA since 2012.

Cargo missions are always packed with some interesting payloads typically several tons of experiment equipment, food and other provisions.

But Mondays mission willcarry something the space station has never seen before: A supercomputer built by Hewlett Packard Enterprise, dubbed the Spaceborne Computer.

If it works, it could be the most powerful commercial computer ever to operate in space.

Astronauts aboard the space station already have a bunch of devices youd find at your local electronics store including HP laptops.

Related: SpaceX now valued at $21 billion

But a supercomputer is something different. Its a much more powerful piece of hardware that can crunch massive amounts of data and send the results to other computers in just moments.

According to Mark Fernandez, the HPE engineer who is heading up this new experiment, the space-bound supercomputer will have the ability to make one trillion calculations in a single second about 30 to 100 times more powerful than your average desktop computer.

Julie Robinson, the chief scientist for NASAs space station program, said if this supercomputer can function in the harsh conditions of space itll be very exciting news for companies down here on earth.

Robinson points out that a huge point of interest for the private sector is taking high-quality satellite images of earth in order to track things like crop growth or oil exploration.

Whats happening is just as your TV now has so much more resolution the same thing is happening with [satellite imagery], she said.

But the high-definition images require 200 to 300 times more data, which can clog up the communication pipeline between earth and space. Thats where a supercomputer on board the space station would become hugely valuable, Robinson told CNNMoney.

If you can process the data on board [the space station], you then only need to send down a subset of the data thats actually needed, she said.

Related: SpaceX rocket finally lifts off after two aborted launch attempts

Will the supercomputer work?

Well find out soon enough. After launch on Monday, SpaceXs Dragon spacecraft will detach from the top portion of the rocket. Itll then fire up its own engines and spend about two days traveling through orbital space.

Then, itll dock with the space station, and the astronauts on board can collect the payload.

Fernandez said HPE has volunteered to have its payload removed last, so itll be a few days into September by the time the supercomputer makes its way onto the space station and is plugged in.

If it powers up, thats going to be my first relief. I will be very excited then, Fernandez told CNNMoney.

Read the rest here:

SpaceX to launch supercomputer to International Space Station - WGN-TV

Posted in Space Exploration | Comments Off on SpaceX to launch supercomputer to International Space Station – WGN-TV

Scientists Land at Caltech This Week to Trade Ideas About Space Exploration on a Budget – Pasadena Now

Posted: at 12:28 pm

A unique conference about the viability and the scientific benefits of low-cost robotic missions in space will be held at Caltechs Cahill Center for Astronomy and Astrophysics starting Tuesday until Thursday, August 15 through 17.

The 12th Low-Cost Planetary Missions Conference, or LCPM-12, sponsored by the International Academy of Astronautics (IAA), serves as an opportunity for scientists, technologists, engineers and project and agency managers to exchange ideas and information to enhance the viability and science return of low-cost robotic missions.

During this time, attendees will exchange ideas and information on the latest Agency Programs and Plans for Low-Cost Planetary Missions, the Latest Science Results from Ongoing Missions, Missions Currently Under Development for Launch in the Near Future, Science Instruments Enabling the Next Generation of Low-Cost Planetary Exploration, and Advanced Concepts for the Next Generation of Low-Cost Missions, including CubeSats, NanoSats and others.

The focus of LCPM-12 is on small and/or low-cost planetary missions, on the scale of the NASA Discovery/ESA Cosmic Vision Small (S) Class and smaller, including Smallsats and CubeSats, the announcement said. The conference will be conducted fully in sequential plenary sessions, augmented by one or more poster sessions.

NASA stated that the size of a small spacecraft, or SmallSats, could vary depending on the application. There are some you can hold in your hand, while others, like Hubble, are as big as a school bus.

SmallSats focus on spacecraft with a mass less than 180 kilograms and about the size of a large kitchen fridge. SmallSats are divided further into such categories as Mini-satellites (between 100 and 180 kilograms), Nanosatellites (one to 10 kilograms), Picosattelites (0.01 to 1 kilogram), and Femtosatellites (0.001 to 0.01 kilogram).

NASAs Ames Research Center first launched Pioneer 10 and 11 as SmallSats in 1972 and 1973, respectively. Today, Ames present SmallSat program is focused on the SmallSat Lunar Prospector launched in 1998, followed by LCROSS in 2009 and LADEE in 2013.

CubeSats are a class of nanosatellites that use a standard size and form factor. The standard CubeSat size uses a one unit or 1U measuring 10x10x10 cms and is extendable to larger sizes 1.5, 2, 3, 6, and even 12U.

Originally developed in 1999 by California Polytechnic State University at San Luis Obispo (Cal Poly) and Stanford University to provide a platform for education and space exploration, CubeSats now provide a cost-effective platform for science investigations, new technology demonstrations and advanced mission concepts using constellations (swarms disaggregated systems).

NASAs Ames Center launched its first CubeSat, GeneSat, in December 2006. Since then Ames has launched 16 CubeSat spacecraft varying in size from 1U to 3U, with an additional 12 CubeSats in development or awaiting launch.

The IAA was founded in Stockholm on August 16, 1960. Since that time, IAA has brought together the worlds foremost experts in the disciplines of astronautics on a regular basis to recognize the accomplishments of their peers, to explore and discuss cutting-edge issues in space research and technology, and to provide direction and guidance in the non-military uses of space and the ongoing exploration of the solar system.

As stated in the Academys statutes, the IAAs purposes are to foster the development of astronautics for peaceful purposes, to recognize individuals who have distinguished themselves in a branch of science or technology related to astronautics, and to provide a program through which the membership can contribute to international endeavors and cooperation in the advancement of aerospace science.

The IAA coordinates closely with national academies to foster a spirit of cooperation and progress that transcends national boundaries, cultures, and institutions.

To learn more about LCPM-12 and view the conference details, visit http://www.lcpm12.org.

Visit link:

Scientists Land at Caltech This Week to Trade Ideas About Space Exploration on a Budget - Pasadena Now

Posted in Space Exploration | Comments Off on Scientists Land at Caltech This Week to Trade Ideas About Space Exploration on a Budget – Pasadena Now

Observer Review A Mindbending Mixture of Cyberpunk and Horror … – Game Revolution

Posted: at 12:25 pm

Developer Bloober Team has an excellent track record when it comes to creating memorable experiences. The teams Layers of Fear was a terrifying addition to the very short list of games that actually scare me, and I knew theyd be one to watch from there. With the introduction of Observer, my love for the developer has grown significantly. The Polish outfit has come a long way since its first DSiWare title in 2011, and its clear theyve found their niche.

While Layers of Fear dealt with psychological horror and similar themes, Observer is a completely new beast for Bloober Team, serving up a decadent slice of cyberpunk horror, treading waters I always find myself asking why other developers simply cant or wont. It is, by far, one of the best games Ive played this year, and while it certainly wont be for everyone, its reminiscent of the classic sci-fi and cyberpunk FMV games and innovative RPGs of the 90s. Its grimy, morbid, and deeply disturbing at times, and thats part of what makes it so good.

Youll take up the role of one Daniel Lazarski, a Class B citizen in 2084s Poland, where castes determine how youll spend the rest of your life. Class A citizens may as well be above the law, Class B citizens may as well be the middle class, and Class C citizens are doomed to a life of poverty. They also make up the majority of Observers vision of Poland.

Lazarski happens to be a police detective but also an observer, or part of a special police force whose members are equipped with special cybernetic enhancements that allow them to jack into others minds in order to obtain information. Its not pretty work, but its extremely necessary in some cases, offering additional insight into citizens may have been murdered or wronged, since the dead obviously cant talk. Its a rugged role, and one that Blade Runners Roy Batty himself, Rutger Hauer, plays with such skill and excellence it seems as though he was destined to play it.

Lazarski finds thrown into the middle of an investigation when he receives a call from his estranged son Adam at the beginning of the game. Shocked that hes hearing from Adam, Lazarski ends up losing the call but tracing it to a dingy old Class C apartment block. He arrives to find all the citizens on lockdown for some reason, which is where youre expected to begin investigating. Whats happened to Adam, and why are all the citizens trapped in their apartments?

Observer is all about looking around and finding different pieces of useful information, items, and persons of interest to jack into so that you can proceed. You can use your own cybernetics to scan the area for clues, then piece them together to figure out where you need to go next. Interestingly enough, there are no enemies youve got to watch out for save for some particularly trippy segments few and far between, but that doesnt make it any less tense. These stealth areas can be frustrating and slow down the pace, making it more difficult to unravel the mystery ahead of you, but theyre not insurmountable.

Though most of your time is spent investigating the apartment building and the surrounding areas picking up clues and questioning people, Observer is hardly dull. The thrill comes from doing those very things. Its easy to say youre just interviewing the tenants in the apartment, but speaking to them is much more than that. Theres a particularly colorful set of people in these rooms, many of them with their own special affliction.

Some are addicted to the virtual world, others are part of a cult-like group with no cybernetic enhancements that view themselves as pure, some are drug dealers and others are just off their rockers. Its easy to understand why they might be when you discover the reason for the lockdown as well as some of their tortured existences, which I wont ruin here, but speaking to these people reveals some truly disturbing and mind-numbingly terrifying stories.

Thats just the tip of the iceberg, however, because youve also got some particularly harrowing moments where youre forced to enter the minds of some of the individuals you meet along the way. These areas are home to some of the most chilling work Ive ever seen in a video game, and as a horror connoisseur Ive seen it all. The atmosphere and visual effects during these segments are masterful, from the mind of a young child where an adult woman has made her own home to the deceased mind of a young woman stealing company secrets and selling them to keep her unborn child and her husband afloat financially.

Glitch-like hallucinations, disgusting creatures, and uncomfortably vivid scenes that mirror the horror of real-life predicaments are here in full force. Theres a child sex ring being ran by some of the tenants in the apartments according to hidden emails you read on terminals, and even an illegal organ market to be uncovered. The devils in the details, and if you search through every nook and cranny in Observer youll find the nastiest of things you probably hoped to never see.

Observer may only take nine or ten hours to complete, or a little longer if you search through the rubble even more so for collectible cards, and it feels like watching an excellent art house cyberpunk film every second. Its grimy characters, seedy underbelly of futuristic Poland, and uncomfortably bizarre storylines combine to make some of the greatest experiences Ive ever had in gaming. It may be a little unorthodox, but its executed fantastically. If youre looking to be simultaneously terrified and intrigued, you need to spend a few days with Daniel Lazarski as an Observer.

Brittany Vincent is anEditor atGameRevolution. You can follow her on Twitter@MolotovCupcake.

A PCcopy ofObserverwas provided by its publisher.Observerisalso available on PS4 and Xbox One.

Go here to read the rest:

Observer Review A Mindbending Mixture of Cyberpunk and Horror ... - Game Revolution

Posted in Cyberpunk | Comments Off on Observer Review A Mindbending Mixture of Cyberpunk and Horror … – Game Revolution

CF Patients in Europe Wanted for Phase 2 Trial of Investigational Therapy RPL554 – Cystic Fibrosis News Today

Posted: at 12:22 pm

Verona Pharmarecentlyannounced the companys accomplishments in the last six months, including an update to the companys clinical trial in cystic fibrosis (CF) and positive interim results for its investigational therapy RPL554.

RPL554 is an inhaled dual inhibitor of two enzymes, phosphodiesterase 3 and 4, and was previously shown to significantly improve lung function when compared to placebo treatment. RPL554 acts as an effective bronchodilator and haspotent anti-inflammatory properties.

Verona is conducting aPhase 2a trial (NCT02919995) evaluating RPL554 in up to 10 patients with CF in the U.K. The study will evaluate the effects of escalating doses of the drugversus placebo in adult CF patients to determine the therapys tolerability, pharmacokinetics (its movement within the body from absorption to distribution, metabolism, and excretion), and pharmacodynamics (its effects and mechanism of action). The effects ofRPL554 on lung function also will be assessed.

The study includes three groups: a high-dose group in whichpatients will receive a single inhaled dose of 6 mg of RPL554; a low-dose group with a single inhaled dose of 1.5 mgof RPL554; and a placebo control group. All three will be administered via a nebulizer.

The study is currently recruiting participants. Results fromthis trial are expected to be available in thefirst half of 2018.

In addition to CF,Verona Pharma also is developing RPL554 for the treatment of chronic obstructive pulmonary disease (COPD) and possibly asthma.

It has been a transformative six months forVerona Pharma, Jan-Anders Karlsson, CEO ofVerona Pharma, said in apress release.We now have the team and funding to deliver a comprehensive package of Phase 2b data for nebulized RPL554 as maintenance therapy for both COPD and CF, as well as for the treatment of acute exacerbations of COPD.

Karlsson said the company looks forward to updating the market on multiple clinical data points in this and coming years.

Read more here:

CF Patients in Europe Wanted for Phase 2 Trial of Investigational Therapy RPL554 - Cystic Fibrosis News Today

Posted in Cf | Comments Off on CF Patients in Europe Wanted for Phase 2 Trial of Investigational Therapy RPL554 – Cystic Fibrosis News Today

Kate Farms Launches Core Essentials Peptide Tube Feeding Formula for CF, Other Conditions – Cystic Fibrosis News Today

Posted: at 12:22 pm

Kate Farms, which specializes in plant-based, ready-to-use oral and tube feeding formulas, has rolled out itsCore Essentials Peptide 1.5 product. The high-caloric, peptide-based formula contains no dairy, soy, gluten, or other common allergens.

With its approval by the Healthcare Common Procedure Coding System (HCPCS), it is now possible for patients across the U.S. to have the Core Essentials Peptide 1.5 formula covered by Medicare, Medicaid, and private health insurance programs.

According to Kate Farms, about 437,000 people in the U.S. are getting their nutrition primarily through a tube on a long-term basis. Conditions that may lead to weight loss and the inability to assimilate nutrition orally include cystic fibrosis (CF), cerebral palsy, ALS, multiple sclerosis, and many types of cancer.

The Feeding Tube Awareness Foundation, a nonprofitcharity dedicated to supporting parents of children who are being tube-fed and promoting tube feeding as a lifesaving medical intervention, has identified more than 300 conditions that can require children to need nutritional support through tube feeding.

Before Kate Farms launched its Core Essentials Peptide 1.5 nationally, it supplied physicians and registered dietitians with samples of the new product for their patients to try. As a result, many patients have transitioned to the Peptide formula as a better nutritional alternative to what they had been using, according to Kate Farms. The company will also provide free samples to individuals with a prescribed need for liquid nutrition at the request of a licensed health care professional. Sample program terms and conditions can be found here.

I have had the opportunity to provide Kate Farms Core Essentials Peptide to my patients, and they are showing great improvement in their health, their weight gain, and how much they enjoy it, Dr. Annette Whitney, a pediatric gastroenterologist with Digestive Health Associates of Texas, said in a Kate Farms press release.I am thrilled that the product is now covered by insurance, making it accessible to so many more patients, said Whitney, whose practice isaffiliated with Medical City Childrens Hospital and Childrens Health.

Kate Farms Core Essentials Peptide 1.5 is designed to promote healing of the gastrointestinal tract. It contains a variety of natural and easily digestible ingredients to supply caloric density.

Each 325 mL carton serving of Core Essentials Peptide 1.5 provides: 500 calories, or 1.5 cal / mL; 24 grams of organic hydrolyzed pea protein and essential amino acids; MCT oil from coconut, and omega 3 and omega 6 from organic flax seed oil.

Like other Kate Farms Core Essentials formulas, the Peptide formula is: Free of the top allergens (no milk, wheat, soybeans, eggs, peanuts, tree nuts, fish, shellfish) and corn; Made with organic ingredients; Non-GMO Project Verified; Includes a blend of 29 superfoods that provide antioxidants; Certified gluten-free by The National Celiac Association; Certified OU Kosher; Covered by insurance.

The formula also contains the probiotic agave inulin, has no high-fructose corn syrup, and flows smoothly through the tube.

Full nutritional and ingredients details can be downloaded here.

For enteral patients, it makes a world of difference when Im able to offer formulas that provide healthy sources of nutrition that are easily digestible but that can often be hard to find, said Zachari Breeding, clinical nutrition manager at Kate Farms. As a dietitian, Im excited to now be able to order nutritional formulas that are covered by insurance.

The story behind Kate Farms is about Richard and Michelle Lavers daughter Kate, who was born with cerebral palsy and weighed only 16 pounds when she was 4 years old. Doctors said she was failing to thrive.

Kate has had four Kate Farms shakes a day for years and she is now thriving and able to go to school to live her best life, Brett Matthews, chairman and CEO of Kate Farms, said in the release. We are inspired by Kate and also the stories we hear each day from tube-feeders, caregivers, medical professionals and all who are using Kate Farms as a cornerstone to their overall health and well-being.

We believe in the power of nutrition to heal and are excited to offer Kate Farms Core Essentials as a choice for tube feeders across the nation, Matthews said.

For more information, visithttps://katefarms.com.

See the original post here:

Kate Farms Launches Core Essentials Peptide Tube Feeding Formula for CF, Other Conditions - Cystic Fibrosis News Today

Posted in Cf | Comments Off on Kate Farms Launches Core Essentials Peptide Tube Feeding Formula for CF, Other Conditions – Cystic Fibrosis News Today