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Monthly Archives: July 2017
LedgerX Just Gave Us Another Way to Bet Against Bitcoin – Fortune
Posted: July 25, 2017 at 11:50 am
Investors will soon have yet another way to bet on or against Bitcoin.
Namely, cryptocurrency traders will now be able to place option bets on digital money via LedgerX. That came after the Commodity Futures Trading Commission granted LedgerX approval to clear derivatives , making it the first federally regulated platform of its kind.
The approval will also give buyers of Ethereum and Bitcoin several regulated ways to lower the risk on their existing cryptocurrency bets which may be welcome or may increase their risk in the hopes of potentially outsized returns. That's possible because derivatives are a varied group that includes options and future contracts.
"Our recently-granted licenses give LedgerX an enormous regulatory advantage for serving our institutional customers," wrote the company's CEO Paul Chou in a blog post after the decision. "LedgerX offers our customers a one-stop shop for tools to buy and sell spot bitcoin, derivatives, and all manner of specialized cryptocurrency swaps."
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LedgerX, which plans to roll out bitcoin options first starting in the fall, may also make it easier for investors to short cryptocurrencies. While it isn't the first to offer bitcoin options, LedgerX is the first to offer options regulated by the CFTC. In 2015, a San Francisco-based bitcoin options trading platform Derivabit, also known as Coinflip, was asked to cease operations by the CFTC in 2015 for failing to register with the agency.
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There’s a strange new twist in bitcoin’s civil warand a way to bet on the outcome – Quartz
Posted: at 11:50 am
Just as the bitcoin world thought it was safe, a new threat to the cryptocurrencys stability has emerged.
Last week, the price of bitcoin rallied near all-time highs as a proposal to increase its transaction capacity was backed by over 97% of the cryptocurrencys miners, reducing the odds of a so-called hard fork. But now, a weird new proposal has emerged that guarantees a split in the currency on Aug. 1. This time, however, the bitcoin world isnt freaking out about it.
Last weeks relief rally came in response to what was called Bitcoin Improvement Proposal (BIP) 91. Nearly all minerswho process transactions and introduce new bitcoins to the money supplybacked it. But BIP 91 stops short of delivering what a vocal faction of the bitcoin world wants: A greatly increased limit on the number of transactions the network can handle, also called the block size limit.
Some quick background on this increasingly messy situation: Bitcoins creator set an arbitrary cap on the block size of 1 megabyte. The so-called civil war in bitcoin over the past few years has centered on whether that limit should be changed, how, and by how much. BIP 91 will double the maximum number of transactions on the bitcoin network but, crucially, without touching the hard-coded 1-megabyte limit. It achieves this with a workaround called Segregated Witness, or SegWit, that cleverly cleaves off chunks of transaction data, freeing up space for more transactions.
Since SegWit doesnt change the block-size limit, some bitcoiners feel that its simply kicking the can down the road. They also fear it could diminish the bitcoin networks importance, as SegWit paves the way for layer two solutions that will allow speedy and voluminous transactions to take place outside the bitcoin network. This creates a scenario in which most transactions take place off the bitcoin network, with the occasional settlement transaction on the network.
Which brings us to the new proposal, which is confusingly named bitcoin cash. It calls for an eight-fold increase in the block-size limit on Aug. 1. Its name alludes to the faction that wants bitcoin to be a payment networkas readily available and easy to use as cashas opposed to the group that sees bitcoin as akin to digital gold.
One exchange has started a futures market for bitcoin cash, since it doesnt actually exist yet. On its first day of trading, on July 23, one unit of bitcoin cash traded for around half a bitcoin. It has slipped to around 0.2 bitcoin per bitcoin cash at the time of writing.
Although bitcoin cash is certain to enact a hard fork in the cryptocurrency, that will matter only if it attracts enough miners to keep it going. Then, bitcoin and bitcoin cash could end up like ethereum and ethereum classic; two separate but viable coins that originated from the same blockchain. If miners ignore bitcoin cash, it will simply fade away as its transactions are rejected by miners.
With a week to go until Aug. 1, the value of bitcoin cash versus bitcoin will gauge the markets confidence in this new rival prevailing in bitcoins raging internal conflict.
Read next: Bitcoins civil war threatens to blow up the cryptocurrency itself
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7 Cryptocurrency Predictions From the Experts – Fortune
Posted: at 11:50 am
Fortune convened some top cryptocurrency entrepreneurs, venture capitalists, bankers, and others to chat about the future of digital money at Fortunes Brainstorm Tech conference in Aspen, Colo. last week. A select group met at the Aspen Institute for a breakfast roundtable discussion on Wednesday morning.
Headliners on the panel included Balaji Srinivasan , CEO and cofounder of 21.co, a cryptocurrency startup that has raised more in traditional VC funding than almost other one. Another was Peter Smith, CEO and cofounder of Blockchain, a U.K.-based cryptocurrency wallet company that recently raised $40 million from GV , the venture capital arm of Alphabet , parent company of Google ( goog ) . And Kathleen Breitman, CEO and cofounder of Tezos, a blockchain startup that this year raised more than $200 million in an initial coin offering, or ICO, and which counts celeb investors Tim Draper and Mark Cuban among its backers.
The crew of experts weighed in on everything from the longevity of Bitcoin, the original cryptocurrency and blockchain, or cryptographically secured public ledger, to the latest trend of hosting so-called token sales to fund projects, especially on Ethereum , a rival blockchain to Bitcoins, to the future of a decentralized web. Here are some of the predictions we heard.
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Most people who are enthusiastic about cryptocurrency appear to agree that Bitcoin and its newer rival Ethereum have staying power, though they may be more bullish on one versus the other. "In terms of 5 to 10 years, Bitcoin and Ether will be around I bet," Balaji Srinivasan told the room of more than 70 people.
Peter Smith said his company, Blockchain, which was early to Bitcoin, has only just started to warm up to newcomer Ethereum. In contrast, Mike Cagney, CEO and cofounder of SoFi, a personal finance company, said during a separate session on the main stage that he was hotter on the latter technology .
Bitcoin "has some purpose but its application for commercial transaction is limited right now," Cagney said. "The blockchain and Ethereum, on the other hand, have absolutely fascinating infrastructure applications, he continued, mentioning the possibility to overhaul title insurance, which involves policies related to real estate, as one example.
Bitcoin and Ethereum may have stolen the show at this point, but the innovation wont end there. Expect more winners on the horizon.
Kathleen Breitman is hopeful that Tezos, her own blockchain bet, will fill a niche that solves problems with extant blockchains. In particular, she and her projects developers are designing Tezos to automatically push software updates out to the network, thus, in theory, avoiding the divisive feuding over upgrades that has wracked systems like Bitcoin over the past few years.
No one can say how many tokens and coins and blockchain protocols will eventually win out, but the experts seem to think theres room for a multitude. "Its likely that another one or two dominant ones we havent seen yet in the market," Smith projected. "Another really dominant coin could come out this year or next year.
For the time being, token sales might seem like a fantastic way to raise a lot of money quickly and with few questions asked. Will this lead to riches for some? Undoubtedlyindeed, it already has. And rip-offs for others? Almost certainly.
Smith said he presumes that market manipulation and insider dealing is rampant among purveyors of initial coin offerings. Were cautious about it in the short term, Smith said of his company. But you have to temper that with the idea that every new technology is going to be like that in the beginning.
Brad Garlinghouse, CEO of Ripple and a former executive at Yahoo , voiced his less forgiving concerns about the sector on a separate panel. Heavily regulated markets are typically heavily regulated for a reason, he said. Frauds are happening, people are going to jail.
The days of making a pilgrimage to the homes of the holders of purse strings are coming to an end. In a world where anyone can participate as an investor online, physical location matters much less.
It used to be you had to come to Silicon Valley, walk up Sand Hill Road, network with individuals, Srinivasan said about entrepreneurs seeking funding, often strolling up a strip to the west of Palo Alto that long has been associated with venture capital firms. ICOs change all that.
Projects are already getting funded this Kickstarter-like new way. Breitman said she that when she set up Tezos token sale, she aimed to get as many people who wanted to participate in the ecosystem to contribute. The company raised more than $200 million to date and, according to her, more than 30,000 Tezos wallets have been opened.
Elena Kvochko, chief information officer of the security division at Barclays, said that her bank has had many talks with regulators about Bitcoin and its ilk. The rule-sticklers actually dont mind working with Bitcoin, she said. What they do care about is financial institutions obeying know your customer laws, which prevent terrorists and other sanctioned groups from getting financed.
Meanwhile, as governments settle on sets of rules of the road, countries like Switzerland, Singapore, and Estonia are jostling to develop frameworks that easily accommodate the new technology, Srinivasan said. Theyre seeking to displace geographic incumbents and become hubs for a new wave of business financing. If youre a U.S. person or business, you have a good deal to be concerned about, Smith said.
Breitman added that until the rules are agreed upon, its best to be transparent about what one is doing.
As cryptocurrency prices fluctuate wildly, speculators have been having a field day. However, theres reason to believe the markets will become more stable, as Bitcoin gradually has over the past couple of years (despite its still big price swings), Smith said.
In order for these computer coins to catch on big-time, they need a use-case that beats traditional money. Ideally, this ought to be better than merely buying drugs, as Jeff John Roberts, Fortune reporter and the sessions moderator, noted.
Srinivasan proposed one possible scenario. Imagine that all your waking hours are spent in the Matrix, he said, referring to a virtual reality in which everyone is enmeshed in the future. As people from all over the world meet and interact, they will need a medium of exchange. To transact, you cant just hand over a dollar bill, Srinivasan said. You need an international currency for that.
It might take a while but theres going to be more of a need to transact across borders than there is today, he said.
Whenever a consumer swipes or dips a credit card, payment processors charge a fee.
Nicko van Someren, chief technology officer of the Linux Foundation, pointed out that the fee companies like Visa or Mastercard charge exceeds the cost to clear or settle transactions. These businesses can potentially process transactions quicker and cheaper, he contended.
One potential outcome of the adoption of alternate systems, like Bitcoin, is to provide companies with the impetus to improve their services. Bitcoin is good because it will make banks move toward the real cost of handling these transactions, van Someren said. (By extension, in Ethereum's case, one could imagine upstart companies built on it forcing giants like Amazon , Facebook , or Dropbox to reconsider or improve their respective offerings.)
Smith, meanwhile, was less optimistic about incumbents ability to adapt to such change. I dont think be lot of room for banks to simply adjust their price models, he said.
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Explore the International Space Station with Google Street View – Space.com
Posted: at 11:49 am
Aspiring astronauts can now pretend to float on the International Space Station (ISS), thanks to Google. The company worked with astronauts on the orbiting complex to provide a Google Street View of the space station, from its science labs to its beautiful Earth-facing Cupola window.
Thomas Pesquet, a European Space Agency astronaut who helped collect the images earlier this year, said in a blog post that the experience of capturing the tour "describes the feeling of being in space" better than words or a picture can. But there were limitations to collecting the data. For one, astronauts float in space, so the imagery of the ISS couldn't be captured the same way as other Google Street View locations.
NASA's Johnson Space Center in Houston and Marshall Space Flight Center in Alabama worked with Google to create a "gravity-free method of collecting the imagery," Pesquet said in the blog post. These methods included using DSLR cameras and other equipment already available at the space station. An extended video provides an additional look at how the view came together. (Pesquet didn't specify the other equipment in the blog post.) [The International Space Station: Inside and Out (Infographic)]
"I collected still photos in space, that were sent down to Earth where they were stitched together to create panoramic 360 degree imagery of the ISS," Pesquet wrote.
"We did a lot of troubleshooting before collecting the final imagery that you see today in Street View," he added.
"The ISS has technical equipment on all surfaces, with lots of cables and a complicated layout with modules shooting off in all directions left, right, up, down," Pesquet wrote. "And it's a busy place, with six crew members [at the time] carrying out research and maintenance activities 12 hours a day. There are a lot of obstacles up there, and we had limited time to capture the imagery, so we had to be confident that our approach would work."
The International Space Station's U.S. laboratory module as seen through Google Street View.
The tour is the first Google Street View captured in space, and it features annotations that pop up to explain additional information about each module, such as how astronauts stay physically fit or the kinds of food they eat.
You can read the entire blog post here: https://www.blog.google/products/maps/welcome-outer-space-view/ and take a virtual tour of the International Space Station here in Google Street View: https://www.google.com/streetview/#international-space-station/
The International Space Station's Cupola observation module as seen through Google Street View.
The ISS has been occupied continuously since November 2000. It generally houses three to six crewmembers, who split their days between science and maintenance activities. Crewmembers currently "commute" to space on the Russian Soyuz spacecraft, but within the next few years, commercial spacecraft from SpaceX and Boeing will ferry astronauts from U.S. soil for the first time since the space shuttle's retirement in 2011.
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Explore the International Space Station Using Google Street View – Smithsonian
Posted: at 11:49 am
SmartNews Keeping you current Looking out at Earth from the Cupola Observation Module of the International Space Station on Google Street View (Google / YouTube)
smithsonian.com July 24, 2017
Google Street View has taken armchair explorers to some of Earth's most exotic locations, fromthe ancient ruins ofAngkorandMachuPicchuto the natural wonders of theGalapagos Islandsand theGrand Canyon.But its newest location is (literally) out of this world: the International Space Station. AsThuyOngreports forThe Verge,you can now explore the ISS from your own computer screen without suffering the challengesof spaceflight.
"In the six months that I spent on the International Space Station, it was difficult to find the words or take a picture that accurately describes the feeling of being in space," French astronaut Thomas Pesquet writes in a blog postannouncing the new Street View location. "Working with Google on my latest mission, I captured Street View imagery to show what the ISS looks like from the inside, and share what its like to look down on Earth from outer space."
According to Pesquet, the team couldn't usethe bulky backpacks or car-mounted devices usually used to record Google Street View locations. Not only is it difficultto send new equipment to the station,it's a pretty cramped environment. And then there's the issue of microgravity.
"All of our Street View procedures are predicated on the existence of gravity," Stafford Marquardt jokes in a video about the new Street View. Tripods would have to be secured wherever they were positioned. And photos taken by hand run into the issue that the photographer is constantly floating. So the team had to get creative.
The basic idea is that the astronaut would take images of the space station using a DSLR camera already on theISS. Then the images would be stitched back together on Earth. The problem is thateach image must be taken at a similar angle before being stitched, otherwise there would be seams or distortion in the final picture where the images didn't quite line up.
After testing out various methods on Earth, they decided thatPesquetwould stretch two bungee cords in a cross section of the station. Then he would take images, rotating the camera around the center point where the bungee cords cross.
This isn't the first time non-traditional equipment has been used to add to the considerable library of Google Street View. An islander on Denmark'sFaroeIslands used 360-degree camerasstrapped to sheepto map the rocky archipelago, while divers in Australia recorded the Great Barrier Reefwith an underwater camera submarine.
Pesquethopes that being able to explore this collaborative project orbiting thousands of miles above our planet and all of its borders will help people get perspective on the Earth.
"None of this would have been possible without the work of the team on the ground, my colleagues (turned roommates) on theISS, and the countries that came together to send us up to space,"Pesquetwrote in his blog post. "Looking at Earth from above made me think about my own world a little differently, and I hope that theISSon Street View changes your view of the world too."
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Watertown Daily Times | Google Street View’s latest destination: the … – WatertownDailyTimes.com
Posted: at 11:49 am
Youve used Google Street View to check out a new apartment, map traffic before you hit the road and search for haunting slices of the everyday world.
Now, the comprehensive terrestrial mapping system has gone extra-terrestrial, allowing users to peer inside the International Space Station from their computer 248 miles below with 360-degree, panoramic views.
The Street View imagery was captured by Thomas Pesquet, an astronaut with the European Space Agency, who spent six months aboard the ISS before returning to Earth in June.
Google Street View, which is featured in Google Maps and Google World, was launched in 2007 and quickly expanded locations around the globe, including places as remote as Mt. Everest base camp and as offbeat as Loch Ness. The vast majority of Street Views photography is shot by a vehicle, whose movement is available to fans online.
Googles foray into space is the first time Street View imagery was captured beyond planet Earth.
In a blog post about his experience, Pesquet wrote that it was difficult to find the words or take a picture that accurately describes the feeling of being in space.
Working with Google on my latest mission, I captured Street View imagery to show what the ISS looks like from the inside, and share what its like to look down on Earth from space, he added.
The virtual tour allows users to peek into areas where astronauts eat, exercise, work and even bathe.
Pesquets imagery reveal an environment that may look a bit cramped and chaotic if not altogether dizzying to humans anchored on Earth, but some of the scenes from inside the ISS are downright mesmerizing.
The images were captured using DSLR cameras and then stitched together back on Earth to create panoramic views.
Pesquet noted that the ISS is a busy place with six crew members working and researching 12 hours a day.
There are a lot of obstacles up there, and we had limited time to capture the imagery, so we had to be confident that our approach would work. Oh, and theres that whole zero gravity thing, he wrote.
Floating through the ISS online youll notice clickable dots with detailed descriptions of the space and its objects to help viewers understand what exactly theyre looking at. Pesquet noted that this is the first time annotations helpful little notes that pop up as you explore the ISS have been added to Street View imagery.
The ISS is a large spacecraft that orbits around Earth at more than 17,500 mph and is home for astronauts from countries around the world, according to NASA. The ISS is made up of many pieces that were constructed by astronauts beginning in 1998. By 2000, as more pieces of the station were added, the station was ready for people, according to NASA. Portions of the station are connected via modules known as nodes, according to NASA.
The first crew arrived on November 2, 2000, NASA reports. People have lived on the space station ever since. Over time more pieces have been added. NASA and its partners around the world finished the space station in 2011.
NASA compares the inside of the station to the inside of a house, noting that the structure which weighs almost one million pounds and covers an area the side of a football field has five bedrooms, two bathrooms, a gymnasium and a big bay window.
The station houses labs from the United States, Russia, Japan and Europe.
We can collect data on the Earths oceans, atmosphere and land surface, Pesquet wrote. We can conduct experiments and studies that we wouldnt be able to do from Earth, like monitoring how the human body reacts to microgravity, solving mysteries of the immune system, studying cyclones in order to alert populations and governments when a storm is approaching, or monitoring marine litter the rapidly increasing amount waste found in our oceans.
Several times a week, Mission Control at NASAs Johnson Space Center in Houston, Texas, determines where earthlings can spot the station from the ground below from thousands of locations all over the globe. To find out the best time to see the station from your town, go tohttps://spotthestation.nasa.gov.
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Elon Musk’s Mars rocket may be about to lose half of its engines – Ars Technica
Posted: at 11:49 am
Enlarge / SpaceX may be dumping the outer ring of 21 engines for its new Mars vehicle.
SpaceX
Last year, SpaceX founder Elon Musk shared plans for his transportation system to send humans to Mars in the 2020s. But the fantastically huge rocket, with 42 Raptor engines and enormous technical challenges, seemed more like science fiction than reality. Then there was the small matter of who would pay the tens of billions of dollars to develop a rocket that had fewif anycommercial prospects beyond sending 100 people to Mars at a time.
Musk seems to have realized that his ambitions were a tad too ambitious in recent months, and has said he will release a "revised" plan for Mars colonization that addresses some of these technical and fiscal questions. Now, we know this discussion will come duringthe 2017 International Astronautical Conference in Adelaide, Australia, on September 29. And this weekend, Musk dropped a big hint about the change.
In response to a question on Twitter, Musk wrote, "A 9m diameter vehicle fits in our existing factories ..." And this is actually quite a substantial hint, because the original "Interplanetary Transport System" had a massive 12-meter diameter. By scaling back to 9 meters, this suggests that Musk plans to remove the outer ring of 21 Raptor engines, leaving a vehicle with 21 engines instead of the original 42. While still complicated to manage during launch and flight, 21 engines seems more reasonable. Such a vehicle would also have about 50 percent less mass.
At 9 meters the revised Mars rocket would still be considerably larger than SpaceX's current booster, the 3.7-meter Falcon 9 rocket. But it would be smaller than the most powerful rocket ever flown, the 10-meter Saturn V booster that launched the Apollo crews to the Moon.
Downscaling the Mars booster suggests that Musk may be bending toward reality. A 9-meter rocket means that it could be produced in SpaceX's existing facilities, saving the company the expense of building a much larger factory. (Pragmatically, it could also be produced in NASA's rocket factory in Michoud, La., without major renovations). A smaller, but still powerful rocket also opens the door to commercial opportunities and military contracts.
Most notably, the US Air Force is in the midst of soliciting bids for the second phase of a $2 billion competition to develop new launch vehicles that can meet the government's space mission needs. This is part of the Air Force's efforts to end US reliance on the Russian-made RD-180 engine, and this competition is for development contracts to build launch systems capable of flying missions by the early- to mid-2020s. It is possible, then, that SpaceX may bid for some of these funds to help develop the Mars rocket, perhaps for the Raptor engine, or the entire vehicle.
A successful Air Force bid would answer one important question Musk faceshow to pay for the Mars rocket. An answer to another key question could come later this year, whether SpaceX can really manage to control dozens of rocket engines during flight. Although the Falcon Heavy rocket has a different configuration from the Mars rocket, it requires the coordination of 27 Merlin engines during launch. If SpaceX can do that during the Falcon Heavy's maiden launchpossibly later this yearthen controlling 21 engines on the Mars rocket doesn't seem to be that great of a stretch.
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Buzz Aldrin Says Humans Need To Get Off Earth – The Fresh Toast
Posted: at 11:49 am
There are two types of people in this world: those who walk on Mars if given the chance, and those who would not. Buzz Aldrin recently helped create a virtual reality experience that will help humans experience what it might be like to walk on Mars, if youre so inclined.
Buzz Aldrin famously is the second man to walk on the moon. An acclaimed astronaut and engineer, Aldrin has long been a spokesman in explaining humans journey into the cosmos. He has dedicated his life to furthering our scientific understanding and inspiring more into a path among the stars.
Aldrin doesnt want walking on Mars to be limited to a VR program, however. As he stated in an interview with Futurism, he believes that humans should be interested beyond simple exploration.
One of the things that makes space exploration so exciting is that the possibilities are endless, he told Futurism. Mars is the next actionable step for uswe have never been closer to knowing and exploring another planet. Plus, I believe that Mars has realistic potential for colonization.
That colonization may come sooner than you think. As Aldrin later added, Now is the time to start thinking seriously about what life on Mars might look like in the future. I believe we can have the first Human Martians at Mars by 2040.
With worries rising from the scientific community over climate change, a Mars colonization could prove advantageous. Though Aldrin acknowledges not everyone will be able to step on Mars anytime soon, he does hope these VR and AR programs will stimulate national interest in supporting our nautical journeys.
It is in our nature to explore, Aldrin said. We, as a species, are curious and want to see whats over the next hill, see how fast we can go. It was only 66 years from the point that the Wright brothers flew to us flying rockets to the Moon.
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New research suggests the interior of the Moon may contain an abundance of water – TechSpot
Posted: at 11:48 am
The interior of the Moon may be hiding a surprising secret, new research suggests (sorry, conspiracy theorists its not an underground lunar base).
Scientists for years thought our nearby satellite was a dry and barren place. Opinions changed in the 1960s although it wasnt until 2008 that scientists confirmed their newfound suspicion with the discovery of small amounts of water trapped within beads of glass found in lunar samples collected during the Apollo 15 and Apollo 17 missions in the early 70s.
Researchers at Brown University recently analyzed satellite data from the Moon Mineralogy Mapper instrument aboard India's Chandrayaan-1 probe. As Space.com highlights, the instrument measures reflected sunlight at visible and near-infrared wavelengths.
Geologist Ralph Milliken, lead author of the new study, notes that different minerals and compounds absorb and reflect light in different ways. By isolating the reflected sunlight from the thermal energy emitted by the Moons surface, they were able to spot regions where H2O and OH absorb light.
The water they observed was in pyroclastic deposits on the surface of the Moon. Since these types of deposits are the result of volcanic eruptions, it means they likely originated deep within the interior of the Moon. Milliken notes that their findings suggest most of the mantle of the Moon may be wet.
How the water got there to begin with, however, remains a mystery. Earlier theories suggested most of the water on the Moon came from asteroids and comets carrying liquid.
If accurate, the findings could bode well for future colonization efforts as bringing water from Earth would be both heavy and expensive.
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15 facts about fecal transplants The straight poop – Genetic Literacy Project
Posted: at 11:48 am
I was a little surprised to see Ethical Issues in Fecal Microbiota Transplantation festooning the cover of the May issue of The American Journal of Bioethics not their typical topics of gene editing and testing, stem cells, and medical matters of life or death. But as fecal transplants become more medically accepted, questions of access and quality control are indeed arising. So here are a few scintillating facts about borrowing bowel microbiomes to combat dysbiosis.
1. The only sort-of approved use of FMT is for recurrent infection with Clostridium difficile, which causes severe diarrhea. The infection is usually acquired in a health care facility. A 2013 FDA enforcement discretionruling allows doctors to provide FMT without filing an Investigational New Drug Application but only to treat C. diff infection (CDI). Its 90% effective! The procedure is in clinical trials for other indications, albeit against a backdrop of widespread DIYvariations on the theme.
2. The procedure may become frontline treatment for CDI, not just a last resort when antibiotics have failed to control the terrifying torrents of watery stool. And its needed. Results of a study reported in the Annals of Internal Medicine found that cases of multiply recurrent CDI more than two bouts in a short time period are increasing at more than four times the rate of the infection in general. The numbers are daunting: up to half of the 500,000 people in the US who get CDI annually get it again at least once, for a total cost exceeding $5 billion a year. Drug resistant strains are arising and new drugs are coming on the market, but a fecal transplant may be the way to go from the get-go. CDI, say many whove had it, is far worse than overcoming the ick factor of receiving a bit of foreign poop.
3. Some medical organizations and insurers (including Medicare) cover fecal transplants for CDI.
4. Whats in a bowel movement? From 25 percent to54 percentof the solid portion after removing the 75 percent thats water consists of bacteria. The rest is undigested nutrients, electrolytes, and mucus, with color from bile pigments and odor from bacterial compounds (phenols, indole, skatole, ammonia, and hydrogen sulfide). But stool composition varies daily in individuals, which will complicate standardizing transplants. It also presents an obstacle to using a microbiome profile as a form of identification. One bioethicist mentioned checking stool at airports to see whether travelers have come from countries banned from immigration. Would a passport from a Swede be accepted if her feces harbor bacteria native to Somalia?
5. Fecal transplants may conjure mental images of turkey basters, but the material is delivered via enema, colonoscope, nasogastric tube (a nose hose), or capsule.
6. The technology is at least 1,700 years old. The first recorded use was in4th century China by a physician, Ge Hong, to treat food poisoning and diarrhea. In various times and places, poop has been delivered as yellow soup to humans and other animals (especially cattle) and German soldiers reportedly infused camel feces to treat bacterial diarrhea during World War I.
7. Reductionists attempting to drill down to the good stuff in a turd and then recreate it note that just part of a microbiome need be transferred, akin to a keystone organism in an ecosystem. Seres Therapeutics SER-109a capsule that delivers an ecology of bacterial spores enriched and purified from healthy, screened human donors is in phase 3 clinical trials to treat CDI. More mysterious is SER-262 the first synthetically-derived and designed microbiome therapeutic. It fared well against placebo in a 24-week phase 1 randomized controlled clinical trial.
8. Researchers are hard at work describing the optimal feces donor. Most references cite the Amsterdam protocolin this regard. And the American Gastroenterological Association maintains a National FMT Registrytomonitor adverse events and the details of donors. Will we one day have poop centers much like frozen yogurt shops where a hopeful recipient can order up a particular fecal microbiome? Or even mix flavors?
9. Altering the intestinal microbiome might treat autism, Parkinsons disease, depression, and anxiety, perhaps by affecting serotonin levels, thanks to the gut-brain axis.In an intriguing experiment, stool from people with major depressive disorder had a different effect on depression-like behaviors when transplanted into germ-free mice compared to the rodents more spirited response to stool from happy humans.
10. Should people pay for poop, like they do for sperm? Should we patent exceptionally healing donations? Anyone remember The Repository for Germinal Choice, an ill-fated California sperm bank for Nobel-prizewinners?
11. Delivery. Once feces donations are standardized, how will they be prepared and shipped? Dried out like sea monkeys? Fedex? UPS? Amazon Prime?
12. Should informed consent for a recipient include knowing the donors diet? Would a transplant from a person who ate pork be like implanting pig heart valves into an orthodox Jewish person? Might a recipient request a vegan donor?
13. OpenBiomeis a nonprofit stool bank that sends frozen matter to hospitals. Founded by a relative of someone who fought CDI futilely with seven rounds of vancomycin before a transplant helped, the company pays $40 for donating several times a week for two months. Stool must pass two rounds of screening, and the original owner must be aged 18-50, have a BMI under 30, and live nearCambridge, MA, where donations are deposited. The homepage opens to an image of clean, white bottles countering the ick factor is a big challenge for this emerging industry.
14. Fecal transplantation may have unexpected effects, especially since standardizing it as a medical substance is so challenging. The first noted was obesity, which is sort of obvious, but one man who had alopecia since age 6 had a transplant to treat CDI and grew so much hair that he had to shave!
15. AdvancingBiotreats private payers. Prep costs $115 and delivery depends on the route: esophagogastroduodenoscopy (down the hatch) is $307 and colonoscopy $341 to $591. The become a donor page shows 10 smiling people, most of them millennials. Those willing to sell their excrement must be between the ages of 18 and 65, have a BMI under 35, provide a medical history, and have a blood test for infections, including cholera, E. coli, plague, foodborne Salmonella and Shigella, as well as various eggs and larvae. Presumably the donation must score a healthy type 3 or 4 on the Bristol Stool Chart.
Stay tuned. Scatological jokes aside, fecal transplantation is a valid medical procedure that will likely continue to find new niches.
Ricki Lewis has a PhD in genetics and is a genetics counselor, science writer and author of Human Genetics: The Basics. Follow her at her website or Twitter @rickilewis.
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15 facts about fecal transplants The straight poop - Genetic Literacy Project
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