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Monthly Archives: May 2017
Space Station Soundtrack: Astronaut Thomas Pesquet Shares His #Songs4Space – Space.com
Posted: May 28, 2017 at 7:17 am
Space station astronaut Thomas Pesquet received a saxophone surprise for his birthday. It arrived on the SpaceX Dragon on Feb. 23 and was hidden by Pesquet's crewmates until his birthday on Feb. 27.
There aren't many sounds to hear in space, but there has certainly been no shortage of music at the International Space Station (ISS) ever since French astronaut Thomas Pesquet arrived.
A first-time space traveler, Pesquet is getting ready to wrap up his six-month stay aboard the space station. Whenever he wasn't working on science experiments or spacewalks, Pesquet spent much of his spare time listening to music, playing his saxophone, and even recording a music video.
Pesquet also created a soundtrack for his life in orbit by regularly tweeting songs with the hashtag #songs4space. Whether he's getting ready for a spacewalk, looking at the moon or eating home-grown lettuce, Pesquet has a song for everything. [Gallery: French Astronaut Thomas Pesquet's Amazing Photos from Space]
"The terminator is not only a movie: its the line between night and day. We cross it up to 16 times in 24 hours. So it keeps coming back," astronaut Thomas Pesquet wrote on social media when he shared this photo from the International Space Station.
One of the first songs Pesquet shared in space was inspired by a photo he took of Earth through the window of the ISS. Behind one of the station's solar panels is the line between day and night, which is known as the terminator.
As we enter into the night (every 45 minutes) I often think of this song by @iamKAVINSKY Nightcall #songs4space https://t.co/RouGMmLY0G
The terminator passes over people on Earth twice a day during the sunrise and sunset. But the ISS crosses the terminator 16 times a day, orbiting at a speed of about 17,500 mph (28,000 kph). In a tweet, Pesquet said that the constant nightfall often reminds him of a song called "Nightcall" by Kavinsky, a French electronic house music artist.
As the youngest on board I am probably the most playful and competitive! @Santigold - Disparate Youth #songs4space https://t.co/71QhJxw2Is
Pesquet, who turned 39 years old on Feb. 27, is the youngest person of the Expedition 50/51 crew as well as the European Space Agency's astronaut corps. In his second month of life at the ISS, Pesquet claimed that this made him more playful and competitive than his crewmates. Accordingly, he attached the song "Disparate Youth" by Santigold.
There's nothing like home-grown veggies, especially at the International Space Station. "TGIF! Like every Friday evening, we all gather in the Russian segment and share our best food items," astronaut Thomas Pesquet wrote on his Flickr page. "This time, we were very fortunate to eat fresh onboard-grown lettuce, with lobster in wasabi mayonnaise (courtesy of our three-star chef NASA astronaut Peggy Whitson)."
When you're orbiting the Earth about 248 miles (400 kilometers)above the ground, growing your own food isn't easy. So when it's time harvest lettuce from the space station's veggie farm, the astronauts get a bit more excited about mealtime or at least Pesquet does.
When in space, fresh lettuce feels like a Banquet! #Songs4space by @BlocParty https://t.co/IFUL7v4efa
After harvesting some red romaine lettuce in December, Pesquet and his crewmates had a space food feast, topping their fresh leaves with lobster and wasabi mayonnaise. Then he tweeted, "When in space, fresh lettuce feels like a Banquet" with the song "Banquet" by Bloc Party, the English indie-rock band.
A waxing, gibbous moon peeks out from behind Canadarm2, one of the robotic arms outside the International Space Station, in this photo taken by astronaut Thomas Pesquet. "The moon was playing hide and seek with us today but I spotted it!" Pesquet tweeted when he shared the photo.
Shows up, gets photographed, disappears. The moon is such a poser 😉 Funkadelic - Hit It and Quit It #songs4space https://t.co/hkjKlgZifq
While watching a spacewalk in-person for the first time, Pesquet was so impressed with the work of NASA astronauts Peggy Whitson and Shane Kimbrough that he basically called them ninjas. As the two spacewalkers performed a power upgrade outside the ISS, Pesquet tweeted the song "Enter the Ninja" by Die Antwoord.
Great to witness today's spacewalk! Clearly experienced at moving in space @DieAntwoord-Enter The Ninja #songs4space https://t.co/A44MaOuzX4
Before Pesquet did his own spacewalk on March 24, he scheduled a #songs4space tweet reminding himself to not get distracted by all the scenery in space; attaching the song "Pay No Mind" by Madeon and Passion Pit. (Of course, spacewalking astronauts don't have access to Twitter while they're outside in their EVA suits. But it's the thought that counts, right?)
Scheduled #songs4space: A good #spacewalk tune @MadeonPay No Mind (to the scenery as we work)https://t.co/h5A1IvfgJe
Pesquet's first space adventure is coming to an end, but hopefully he won't stop tweeting his #songs4space anytime soon.
Already being asked whats next.. the Moon, Mars? I like to think bigger than that 😉 @TouristJupiter #songs4space https://t.co/55Z5EIda11
You can check out the rest of Pesquet's #songs4space on Twitter.
Email Hanneke Weitering at hweitering@space.com or follow her @hannekescience. Follow us @Spacedotcom, Facebook and Google+. Original article on Space.com.
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Space Station Soundtrack: Astronaut Thomas Pesquet Shares His #Songs4Space - Space.com
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Who Will Build the World’s First Commercial Space Station … – Scientific American
Posted: at 7:17 am
Michael Suffredini has big business plans for low Earth orbit. After a decade as NASAs program manager for the International Space Station (ISS) he retired from the agency in September 2015 to pursue opportunities in the private sector, convinced that a golden age of commercial spaceflight was dawning. Partnering with Kam Ghaffarian, CEO of SGT, the company that operates the ISS for NASA and also trains Americas astronauts, Suffredini co-founded Axiom Space in early 2016.
As Axioms president, Suffredinis goal is simple: to build and fly the worlds first private space station, using the ISS as a springboard. The company is in talks with NASA to install a new commercial module on the ISSs sole available unused docking port as early as 2020 or 2021, and is presently planning the modules construction and flight with aerospace manufacturers and launch providers. Axioms module would be the foundation for a full-blown private space station that would debut after the ISSs retirement, which is tentatively slated for 2024. Detached before the ISS is deorbited to burn up in Earths atmosphere, Axioms module would remain in orbit to serve as the private stations first section.
Axiom, however, is not alone in its bid for private piggybacking on the ISS. Another company, Bigelow Aerospace, is already occupying an ISS port with its bedroom-size Bigelow Expandable Activity Module, or BEAM, a test facility for its own line of proprietary inflatable commercial space stations. Bigelows next major projecta much larger inflatable module in partnership with United Launch Alliancecould fly as soon as 2020. It may directly compete with Axiom for the ISSs last free docking port, and mastery of what could be a multibillion-dollar emerging market in low Earth orbit hundreds of kilometers overhead.
Suffredini spoke with Scientific American about Axioms plans, the ISSs legacy and the race to loft a commercial space station.
[An edited transcript of the interview follows.]
People have talked about making private space stations for decades, even before on-orbit construction began on the ISS. Why is now the right time to finally make this a reality? It is clear to me there is a growing need for a private space station. Our vision is to make living and working in Earth orbit commonplace as a means to sustain deep-space exploration. But in order to build a sustainable exploration capability we have to have a low Earth orbit platform. Its not reasonable to expect that we can do a sustained exploratory program without the capability of testing systems and studying human adaptation to space in low Earth orbit. So thats a given, in my mind.
In order to do that though, in order for governments to explore, they cant really all afford their own infrastructure in low Earth orbit. To me the only reasonable solution is to have a viable commercial platform that governments can use when they need tonot have to own and operateand to be able to use at the level they need when they need [it]. Not as an anchor tenant where you come in and youre always paying this bill. But rather where, okay, you have some work or testing that needs done, you go get it done, and you move on to the next thing. We want to make sure everybody who wants to work in space today has a place they can go to, to do whatever it is theyre doing without having to needlessly start over. That saves costs.
Bill Gerstenmaier [NASAs chief of human spaceflight] has said NASA is going to cede low Earth orbit to commercial industry at some point. The writing is on the wall. So I do think the time is right. We think there are six sectors that make up a plausible revenue stream, and if you look at the business case across all of them you realize, yeah, theres a market there that can support something like Axiom today, and that market will grow over time. You go off and do your math and see how much itll cost to build and operate your stationand if your projections say youll make a buck and be a healthy company, thats what you do. And thats what our analysis told us.
What are the six sectors? Lets start with the ones you probably will recognize first: Scientific research. Manufacturing on orbit. And something I refer to as exploration system testing. Thats all the testing they do on ISS today to get ready for deep-space missions. Today its technology demonstration, tomorrow itll be testing smaller scale versions of systems for deep-space exploration. Then theyll build final systems designs and test those for long periods. And then theres also all the research about human responses to spaceflightI consider that exploration system testing, too. But really its to support whatever the exploration crowd needs to make sure their systems will do what they want far from home. Then theres tourism, which is very easy to understand. Theres also advertising and branding, something not done much on ISS today but that could be done more on a commercial station. Its not a huge market, but its noticeable.
Im counting only five I saved the best for last. The last sector is something I believe Axiom is uniquely able to provide, which is helping more governments get into the business of human spaceflight. There are lots of countries that want to have a meaningful astronaut program, flying their citizens as astronauts rather than as tourists. The associated technology development can help stimulate economy and industry, drive STEM education, boost national pride and a countrys global image. So many countries are interested in getting into that.
Axioms mix of very talented folks and our pool of capabilities put us in a unique position to help countries identify what is needed to become spacefaring, and to train their astronauts for two years or even a bit more, then fly them to orbit for extended periods of timemaybe 60 days just starting out when our module is attached to ISS all the way up to 180 days when we separate and form our own station. Well give them high-performance jet training, just like NASAs astronauts. Well give them extravehicular activity experiencespacewalks. Theyll go through all these normal processes to be certified as astronauts. And over time well help the countries develop in situ capabilities for all of that so they can do their own training and operations, and maybe even bring their own modules to our space station at some point. Because most of these countries want to participate in the partnership that I believe will happen to explore beyond low Earth orbit. When we go beyond low Earth orbit, we should do it as a planet, not as a single country. So thats the sixth: this opportunity to train up and fly new astronauts and help more countries build human spaceflight programs.
It sounds like you could get enough business to justify a private space station right now. So why bring modules to the ISS first? Were bringing our first modules to the ISS in order to transition the legacy that exists, and to continue it. On ISS, whatever year its going to end, about two years before that people will stop making hardware to fly because it just wouldnt be on orbit long enough to justify investment. Youd end up with a dip [in activity], and nobody wants that. That means the most important part of this idea is to make sure we build and launch our modules and get this transition done before the ISS retires, which could happen as soon as 2024, according to NASAs plan. So were staying pretty busy.
What odds would you place on the 2024 retirement? What do you think is the most likely future of the ISS right now? Well, I hate to gamble in public on 2024.
The sooner ISS gets out of orbit, the sooner NASA saves three and a half or even four billion dollars per year, depending on when exactly they deorbit. Thats NASAs yearly operating cost. And then you look at all the other government partners, and between all of them theyre in it probably close to a billion dollars more in terms of yearly costs. Thats money that could instead be spent on exploration work, which makes 2024 seem desirable.
We dont actually have to decide whether to retire the ISS for another several years. NASA probably doesnt have to decide until 2020, although the partners would rather decide in 2019 because thats when their next ministerial council meeting isthose meetings are on a three-year schedule, and 2022 would be pretty late. But there is one unused, available docking port right now on the ISS. So now Im saying we need a commitment from NASA for that port for somebody, some entity that wants to try to [build private space stations]. The ISS can really only support one more significantly large module, mostly due to power constraints. The sooner NASA makes that decision on giving the port to somebody, then the more informed theyll be when they have to decide whether to extend the ISS or not. Because then theyll be able to see how close whomever they select is, in terms of manufacturing and testing and delivering to the launchpad.
So rather than assume an end date, I think the better thing is for us to make those early decisions to make sure a commercial entity can prove itself and help the agencies make an informed decision as soon as possible on actually extending ISS.
Theres got to be competition for that port, then. Are you worried about competitors like Bigelow Aerospace, which is already using the ISS to test technology for their planned private space station? Were really focused on us right nowour product, and making it the best it can be to customers and to NASA when we put our proposal in. Youre right, Bigelow has been very overt about their desire to fly, but I dont know enough about what theyre doing to say how viable they are. What I do know is they are planning on using inflatable technology. Inflatable modules are pretty cool but they have their challenges. How the material itself works is being tested on orbit today, but theres a very big trick in figuring out how youre going to outfit inflatableswhere all the plumbing and other systems will go, and how youre going to ensure stale pockets of air dont form inside, since thats something that could asphyxiate a crew. There are all kinds of things that need to be doneand Im sure they will bebut in the near term I think thats much further away than the time frame we need to fly. At Axiom our concern is about getting to orbit as soon as possible. We really want to fly in early 2020 or 2021.
You mentioned that keeping the ISS up and running costs NASA alone about $3.5 billion each year. Thats a lot of moneyprobably too much for a commercial enterprise to presently sustainand it doesnt account for the developmental costs or the costs shouldered by international partners. So why would a private space station be cheaper? Well, thats a good question. I have almost a dissertation on how well operate to reduce costs. Inherently we will procure differently than governments do, and we will also use new technologies and apply lessons weve learned from the ISS.
The space industry started about 50 years ago, and at the time they didnt have all the advanced manufacturing techniques we have now, and they didnt have as many competing companies or clients. Well compete the contract for building our module to get a good price, and the modules internals will be systems you can largely use on the ground. It will be built using manufacturing techniques common to commercial industry today. ASE standards, which originated in automotive repair, will be a benchmarkSpaceX already uses ASE standards for a lot of things. Using space grade parts under those criteria is not necessary when other, cheaper parts can do the same job. Everything will be checked and checked again to make sure we can safely use those relieved standardsbut that will largely be possible. So were taking maximum advantage of the way the industry has evolved so as to reduce the amount of very specialized requirements and verifications for much of what well have installed in these modules. And if something we have installed there gives you a hard time, you just take it out, plug in a new one, and go on; well be working in a plug and play landscape. And all that means were driving the cost of each module way down.
Speaking of lessons learned from the ISS, that space station, of course, has been controversial. Some advocates of space exploration see it as a detour or a dead weight that has kept us from returning to the moon or going on to Mars. Many scientists believe its relatively meager research returns have not justified its immense multibillion-dollar cost. Couldnt similar criticisms be raised against commercial space stations like Axioms, too? You know, this is always a hard conversation to have. When we went to the moon, it wasnt really because we were interested in the rocks that were there. We were trying to prove to the world that we were technologically very capable. It really was about our concerns in the nuclear age and whether we were technically superior to those we considered to be our potential adversaries. And it drove a huge investment in space, which we benefited from. The ISS is no different, although it was built with a vision by some that we would have this station as the first step toward collaborative deep-space exploration. After the collapse of the Soviet Union we wanted to cooperate with the Russians in a big way, and that was a huge forcing function on the entire project. There were all kinds of impacts from that. We had to fly it in a different [orbital] inclination around the Earth to make it easier to reach using Russian rockets, which complicated things, but it was ultimately approved because of the political influence it gained from that international collaboration.
The ISS was a fantastic vehicle for what we wanted it to dowe were trying to get a bunch of nations with a capability on orbit that we shared, but that at the same time could call our own. The biggest influence it has had is what its done for us as countries working and playing together in space. Despite all the political turmoil of the past few years, in particular with the relationship between Russia and some Western countries, the ISS has always remained completely unscathed. It is a place where we work togethernot as citizens of nations but as human beingsadvancing our cause together.
So you end up with this vehicle with all these modules from all these different countries and they have to all integrate and work together, and that made it much bigger and more expensive than what wed need for a specific research purpose that was out there. If you look at the ISS from the standpoint of the world stage and the advancement of Americas ability to lead in spaceflight, I think it has been huge. If you believe exploration is important to this planet and to our species, it has played an even bigger role. But if you look at it from any single pure and very specific viewpointlike the desire for a robust research bonanzawell, its a different conversation. The ISS has supported a lot of really good research, but if you measured it by the number of Nobel Prize winners that won because of something done onboard, you would be very disappointed. But when you consider it more broadly than just research capability, I think it has been an amazing platform. And extending thatbuilding another platform we expect to be used by the international communityis very important to what we are doing at Axiom.
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Who Will Build the World's First Commercial Space Station ... - Scientific American
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Astronauts Made Urgent Repairs at the International Space Station – TIME
Posted: at 7:17 am
(CAPE CANAVERAL, Fla.) Spacewalking astronauts made urgent repairs at the International Space Station on Tuesday, three days after a critical relay box abruptly failed.
The 250-mile-high (400-kilometer-high) replacement job fell to commander Peggy Whitson, the world's most experienced female astronaut. She now ties the record for most spacewalks by an American 10.
Even though a second relay box managed the data load just fine after Saturday's breakdown, NASA scrambled to put together a spacewalk in order to restore backup capability. The system is vital for operating the station's solar panels, radiators and robotic equipment.
The failed data-relay unit recently refurbished with upgraded software was just installed in March. Hauling out a spare, Whitson photographed the faulty device to help engineers figure out what went wrong. Then she quickly removed it and bolted down the spare, an identical 50-pound (22-kilogram) box measuring 14 by 8 by 13 inches (35-20-33 centimeters) officially known as an MDM or multiplexer-demultiplexer. But when Whitson discovered some metal flecks on some of the bolt holes, she had to pull the spare box back out.
Whitson and Fischer were just out spacewalking on May 12. That excursion was cut short by leaking station equipment, leaving two antenna installations undone. So Fischer completed the chore Tuesday.
Altogether, Tuesday's spacewalk was expected to last no more than a few hours exceedingly short by NASA standards.
"Here we go again," French astronaut Thomas Pesquet said via Twitter as his U.S. colleagues suited up for the spacewalk. As they ventured outside, Pesquet cautioned, "You guys be safe."
It was only the second spacewalk for Fischer, a rookie astronaut who arrived at the orbiting lab last month.
"What's more awesome than being on @Space_Station? Getting a call from mission control 4 another spacewalk! Dancing w/ the cosmos," he said in a tweet.
After he had installed the antennas, Fischer radioed, "Oh my gosh, it's so beautiful," as the station sailed out over the tip of South America and over the South Atlantic.
Whitson is more than halfway through a 9 -month mission. Currently on her third spaceflight, she's spent more time off the planet than any other American and, at age 57, is the oldest woman to ever fly in space. Tuesday's excursion put her in third place on the all-time spacewalking list, behind a Russian and fellow American with more hours out in the vacuum.
The space station also is home to two Russians.
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Ex-Alta 1 satellite is calling home to Alberta – The Globe and Mail
Posted: at 7:17 am
Ex-Alta 1, Albertas first orbiting satellite, is alive and well and phoning home.
The 30-centimetre-long probe, built by students at the University of Alberta, was sprung from the International Space Station at 4:55 EST on Friday morning.
Video footage showed the deployment was successful. The rectangular satellite, roughly the size of a milk carton, can be seen shooting out of a dispenser on the side of the space station and then receding into the deep blue backdrop of Earth scrolling by in the distance.
Also: Student-built satellite puts Alberta into orbit
But Ex-Alta 1s mission team had to wait until the satellite turned on its radio transmitter to be sure everything worked as planned. Confirmation came about 8:40 a.m. EST as the miniature spacecraft passed over East Asia and its radio beacon was picked up by ground stations in Japan and South Korea.
Until now, we couldnt allow ourselves to imagine very far beyond this point, said an elated Charles Nokes, the missions project manager, who joined the U of A effort to develop and launch a homegrown satellite nearly four years ago.
When we last turned it on, it did what it was supposed to do, he added. But theres always a bit of trepidation. Could something go wrong?
Now that the satellite appears to be working, the teams worst-case fears that it would fail to activate after being dormant for 10 months while waiting for launch and then deployment from the space station have finally been banished.
Mr. Nokes said that over the weekend, the team will work on establishing direct contact with Ex-Alta 1 and stabilizing its orientation as it orbits so that it can begin to gather scientific data.
The first measurement should come from a sensitive and lightweight magnetometer that was designed at the University of Alberta and will now get its debut in orbit.
Ex-Alta 1 is the only Canadian representative in a larger international project called QB50 that has helped to shepherd dozens of student satellite teams to the launch pad.
As part of the project, 28 small cubesats from 16 countries are to be released from the space station this month, with eight more scheduled to piggyback off the launch of an Indian satellite in June.
For students hoping to gain project management skills or boost their chances of breaking into the aerospace industry, the experience that comes with getting something into orbit, no matter how small, is hard to top.
Being part of @AlbertaSat with Ex-Alta 1 cubesat was invaluable to me! wrote Kirsten Cote, a graduate student in earth and space science at York University in Toronto and a former team member who was posting updates about the deployment on Twitter early Friday morning.
Its really building the next generation of highly qualified people that could enter the space market or even the high-tech market in the future, said Jean-Claude Piedboeuf, director-general of space science and technology at the Canadian Space Agency.
Dr. Piedboeuf said the agency is now consulting with interested universities as it develops a new initiative to fund 13 student cubesats, one built in each province and territory in Canada. The satellites would be launched in two batches in 2020 and 2021 and would operate for up to 12 months.
Theres a real opportunity here to attract young people into the space sector that would normally see this as something that is too difficult to reach, he said.
Cubesat building has become a popular activity among aerospace programs worldwide. It is a project that university students can realistically accomplish with a price typically in the range of $200,000 per satellite, not including launch.
But while the goal creating a cubesat is increasingly accessible, the technical challenges of spaceflight remain daunting and the potential for failure high.
Mr. Nokes said there were some hard lessons and a lot of backtracking along the way to getting Ex-Alta 1 off the ground. But he added that for students interested in launching their own cubesats, the takeaway message from his teams experience is a positive one.
Its totally doable, he said.
Follow Ivan Semeniuk on Twitter: @ivansemeniuk
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Will Humans Land On Mars In The Next 50 Years? – Forbes – Forbes
Posted: at 7:17 am
Forbes | Will Humans Land On Mars In The Next 50 Years? - Forbes Forbes Will we have landed on Mars in the coming 50 years? This question was originally answered on Quora by Nicolas Nelson. |
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How A Gene Editing Tool Went From Labs To A Middle-School Classroom – NPR
Posted: at 7:16 am
Will Shindel prepares for a gene-editing class using the CRISPR tool at a Brooklyn community lab called Genspace. Alan Yu/WHYY hide caption
Will Shindel prepares for a gene-editing class using the CRISPR tool at a Brooklyn community lab called Genspace.
On a Saturday afternoon, 10 students gather at Genspace, a community lab in Brooklyn, to learn how to edit genes.
There's a recent graduate with a master's in plant biology, a high school student who started a synthetic biology club, a medical student, an eighth grader, and someone who works in pharmaceutical advertising.
"This is so cool to learn about; I hadn't studied biology since like ninth grade," says Ruthie Nachmany, one of the class participants. She had studied anthropology, visual arts, and environmental studies in college, but is now a software engineer.
In the 1970s, personal computers emerged from labs and universities and became something each person could have. That made it possible for people like Nachmany to become a professional programmer despite not having studied it in school.
Some compare that democratization of personal computing in the '70s to the current changes in access to genetic engineering tools.
In 2015, the journal Science declared the gene editing tool CRISPR Cas9 the breakthrough of the year. It let scientists make changes in DNA of living cells easier and cheaper than before. Today, the CRISPR tool is no longer something that only researchers do in labs. You can take classes in gene editing at a community lab. You can buy a $150 kit to do it at home. Some middle schoolers are doing it in their science classes.
Genspace lab manager Will Shindel, who teaches the genome-editing class, says his students are usually professionals who want to learn a new career skill or curious everyday people. "They just know that it's this word that everybody's throwing around," Shindel says. "It's either going to lead to the singularity or the apocalypse."
Shindel, a biologist by training, is one of many people now dreaming about and starting synthetic biology projects using the CRISPR tool. With some friends, he is working on genetically engineering a spicy tomato. Some people are trying to make bacteria produce insulin. At Acera, an elementary and middle school in Massachusetts, 13-year-old Abby Pierce recently completed a CRISPR experiment, genetically modifying bacteria so that it could grow in an antibiotic that would have killed it otherwise.
Pierce's science teacher, Michael Hirsch, made the argument to get genetic engineering kits for his science students to experiment with in class. "It's going to take molecular bio out of the 'Oh man, cool, they do it in labs' to 'Wait, we can do this in our homes,' " Hirsch says. "We could do things like create pigments, and create flavor extracts, and all of these really nifty things safely and carefully in our kitchens."
New skill set
In fact, the University of Pennsylvania's Orkan Telhan argues, genetic engineering will become an increasingly important skill, like coding has been. Telhan is an associate professor of fine arts and emerging design practices and he worked with a biologist and an engineer on a desktop machine that allows anyone to do genetic engineering experiments, without needing a background in biology.
"Biology is the newest technology that people need to learn," Telhan says. "It's a new skill set everyone should learn because it changes the way you manufacture things, it changes the way we learn, store information, think about the world." As an example of a recent application, Telhan points to an Adidas shoe made from bioengineered fiber, inspired by spider silk.
The comparison between genetic engineering and computing is not new. Two years ago at a conference, MIT Media Lab Director Joi Ito gave a talk called "Why bio is the new digital":
Genspace Lab Manager Will Shindel mixes all the chemicals before class, so the students don't have to make calculations to dilute them during the class. Alan Yu/WHYY hide caption
Genspace Lab Manager Will Shindel mixes all the chemicals before class, so the students don't have to make calculations to dilute them during the class.
"You can now take all of the gene bricks, these little parts of genetic code, categorize them as if they were pieces of code, write software using a computer, stick them in a bacteria, reboot the bacteria and the bacteria just as with computers, usually does what you think it does."
'We need to dig deeper'
Gene editing tools have already started a debate about ethics and safety. Some scientists have warned about not just intentionally harmful uses, but also potential unintended consequences or dangerous mistakes in experimentation.
The German government in March sent out a warning about one kind of CRISPR kit, saying officials found potentially harmful bacteria on two kits they tested, though it's not clear how those bacteria got there. The European Centre for Disease Prevention and Control responded with a statement earlier this month that the risk to people using these kits was low and asked EU member states to review their procedures around these kits.
Earlier, the German Federal Office of Consumer Protection and Food Safety also issued a reminder that depending on the kit, genetic-engineering laws still applied, and doing this work outside of a licensed facility with an expert supervisor could lead to a fine of up to 50,000 euros ($56,000).
In the U.S., then-Director of National Intelligence James Clapper in early 2016 added genome editing to a list related to "weapons of mass destruction and proliferation." But bioengineering experts say overall, the U.S. government agencies have long been monitoring the gene-editing and the DIY bio movement "very proactive in understanding" the field, as Johns Hopkins University biosecurity fellow Justin Pahara puts it.
"There is a lot of effort going into understanding the scope of DIY biology, who can do it, what can be done, what are some of the concerns, how do we mitigate risk," says Pahara, who is also a co-founder of bioengineering-kit company Amino Labs. He says DIY bio, or biohacking, poses little security concern for now, being at a very early stage.
"I would suggest that just all of these discussions, including looking into the past at computing and other technologies, [have] really helped us understand that we need to dig deeper," he says.
More variables
As much as the gene-engineering revolution is being compared to the PC revolution before it, bacteria are not as predictable as computers, says Kristala Prather, associate professor of chemical engineering at MIT. Her team studies how to engineer bacteria so they produce chemicals that can be used for fuel, medications and other things.
"I have a first-year graduate student ... who was lamenting the fact that even though she has cloned genes many times before, it's taking her a little while to get things to work well at my lab," Prather says. "And my response to her is that the same is true for about 80 percent of students who come into my group."
Prather explains that engineering bacteria isn't quite like coding because many more variables are at play.
"One of the common mistakes that people make it to assume all water is just water. The water that comes out of the tap in Cambridge is different than the water that comes out of the tap in New York," she says. "So there are very small things like that that can turn out to make a significant difference."
But Prather who remembers writing programs on a Commodore 64 computer as a 13-year-old is nonetheless excited about the prospect of more people learning about genetic engineering through kits and classes: She says even if all this access does right now is get more people excited about becoming scientists, it's still really valuable.
Alan Yu reports for WHYY's health and science show, The Pulse. This story originally appeared on an episode of its podcast called Do It Yourself.
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Genetic Mutation Studies Help Validate New Strategy for Reducing … – Lab Manager Magazine
Posted: at 7:16 am
PHILADELPHIAA new strategyan injectable antibodyfor lowering blood lipids and thereby potentially preventing coronary artery disease and other conditions caused by the build-up of fats, cholesterol, and other substances on the artery walls, is supported by findings from two new studies from researchers in the Perelman School of Medicine at the University of Pennsylvania.
The new approach targets a protein called ANGPTL3, a regulator of enzymes that clear triglycerides and other fat molecules from the blood. Research in recent years has hinted that inherited mutations in the ANGPTL3 gene that disable its function can decrease triglyceride, LDL cholesterol, and HDL cholesterol levels.
As reported in a paper published May 24 online in the New England Journal of Medicine, researchers from Penn Medicine, Regeneron Pharmaceuticals, and a group of international collaborators studied ANGPTL3 in both humans and mice. They found that blocking ANGPTL3 activity with an investigative injectable antibody, known as evinacumab, reduced triglycerides by up to 76 percent and lowered LDL cholesterol 23 percent in human study participants, and largely reversed signs of atherosclerosis in a mouse models.
Researchers also included a human genetics study of approximately 188,000 people, which found that carriers of mutations that disable ANGPTL3 had nearly 40 percent fewer incidents of coronary artery disease as compared to those with fully functioning ANGPTL3.
In the clinic, I treat many patients with very high triglycerides, but our current medications arent lowering triglycerides enough in many cases. Im delighted at the prospect of a new treatment thats a lot more potent, all the more because it lowers LDL at the same time, said study co-author Richard L. Dunbar, MD, assistant professor of cardiovascular medicine and member of Penns Division of Translational Medicine and Human Genetics. Its very reassuring to see that people with this genetic defect actually seem to be protected from heart disease. I think that really bodes well for a therapeutic thats targeting the ANGPTL3 pathway.
In a separate study, published in the March issue of the Journal of the American College of Cardiology (JACC) researchers from Penn Medicine, Harvard Medical School, Washington University in St. Louis, and nine other institutions, who also studied humans and mice, reported on a similar set of findings. Among these was the discovery from another large population sample that carriers of ANGPTL3-inactivating mutations had a 34 percent lower rate of coronary artery disease compared to non-carriers.
We used different lines of evidence to show that ANGPTL3 deficiency is associated with a reduced risk of coronary artery disease, said study co-author Kiran Musunuru, MD, PhD, MPH, an associate professor of Cardiovascular Medicine at Penn. But ultimately we were able to identify that fact that carriers of this genetic mutation did in fact experience a benefitwith little other health risk.
The trial of research on ANGPTL3 as a potential target for atherosclerosis prevention began over a decade ago when scientists reported on two cases of familial hypolipidemia, a rare inherited condition involving abnormally low blood levels of cholesterol and triglycerides. Most cases of familial hypolipidemia are linked to other gene mutations that cause liver and digestive problems, but in members of this American family with the condition, Musunuru found mutations in the gene for ANGPTL3, and no associated health problems.
In the NEJM study from Dunbar and colleagues, the antibody had similar effects in an initial clinical trial in 83 people, lowering the blood levels of triglycerides measured after fasting by about 75 percent at the highest dose, and lowering LDL cholesterol by about 30 percent.
Statins and other drugs are already widely used to lower LDL cholesterol, but there are fewer options for lowering triglycerides. For treating high triglyceride levels theres really nothing out there thats quite this potent, so thats where I expect this new approach to have its greatest therapeutic benefit, Dunbar said.
Hypertriglyceridemia, a condition in which fasting triglyceride levels are greater than 150 mg/dL, is estimated to affect at least tens of millions of American adults. It is associated with coronary artery disease and other forms of atherosclerosis, and can lead to potentially fatal inflammation of the pancreas.
In principle, the strategy of targeting ANGPTL3 could have an even broader use in treating atherosclerosis in the general population. The researchers found that in a mouse model of atherosclerosis, treatment with evinacumab reduced the area of atherosclerotic lesions by 39 percent.
The population study findings, including those from the JACC study, suggest that even the partial inactivation of ANGPTL3carriers typically have one mutant copy of the gene and one working copymay be powerfully protective against coronary artery disease, which has long been one of the leading causes of death in developed countries. In the JACC study, for example, carriers of inactivating ANGPTL3 mutations had only a 17 percent reduction in triglycerides on average. But that modest reduction was associated with a 34 percent reduction in coronary artery disease risk. Moreover, Musunuru and his colleagues found that the people in their sample with the lowest blood levels of ANGPTL3 had a 35 percent lower rate of heart attacks compared to those with the highest ANGPTL3 levels.
Dunbar noted that the population study findings probably have lain to rest a lingering concern about targeting ANGPTL3, namely its effect in lowering not just LDL and triglycerides but also the so-called good cholesterol, known as HDL cholesterol. If lowering HDL were a major concern, then I dont think we would have seen the evidence of overall benefit that we did in this study, he said.
The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the geneas in the family studied by Musunuru and colleaguesare much rarer.
According to Dunbar, the next logical step would be to take evinacumab into larger clinical trials to study its safety, effectiveness, and optimal dosing. The effect of even a single dose lasts for several months, and its plausible that with multiple doses we would see an even deeper and more sustained effect, he said.
Additional Penn authors on the NEJM study include Scott Damrauer, MD, Aeron Small, and Daniel J. Rader MD, and the Journal of the American College of Cardiology study include Xiao Wang, PhD, Daniel J. Rader, MD, and Danish Saleheen, MBBS, PhD.
Funding sources for the studies detailed in this press release included grants from the National Heart, Lung, and Blood Institute (NHLBI) (R01HL131961), (K08HL114642), (R01HL118744), (R01HL127564), and (R21HL120781) and Regeneron Pharmaceuticals.
Editors Note: Dunbar has received grant support from and consulted for Regeneron Pharmaceuticals, Inc.
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Microsoft plans on storing its data on DNA in the next 3 years … – ScienceAlert
Posted: at 7:15 am
If we used DNA like we use magnetic tape to store data today, it's theoretically possible to store all of the information humans have ever recorded in a space roughlythe size of a double garage.
Sharing their goals with MIT Technology Reviewthis week, Microsoft Research computer architects say they want to start storing their data on strands of DNA within the next few years, and expect to have an operational storage system using DNA within a data centre by the end of the decade.
As antiquated as it seems, one of the best ways to store a lot of information in a small space right now is good, old-fashioned magnetic tape- not only is it cheap, it's rugged enough to hold information for up to 30 years, and can hold as much as a terabyte of data per roll.
But when we consider more data has been generated in just the past two years than in all of human history, it seems even magnetic tape might not cut it in the next few decades.
A biological material such as DNA might appear to be an odd choice for backing up large amounts of digital information, yet its ability to pack enormous amounts of data in a tiny space has been clear for more than 70 years.
Back in the 1940s, physicist Erwin "cat in a box" Schrdinger proposed a hereditary "code-script" could be packed into a non-repeating structure he described as an aperiodic crystal.
His suggestion famously inspired James Watson and Francis Crick to determine DNA's helical structure based on the research of Rosalind Franklin, sparking a revolution in understanding the mechanics of life.
While strings of nucleic acid have been used to cram information into living cells for billions of years, its role in IT data storage was demonstrated for the first time just five years ago, when a Harvard University geneticist encoded his book including jpg data for illustrations in just under 55,000 thousand strands of DNA.
Since then, the technology has progressed to the point where scientists have been able to record a whopping 215 petabytes (215 million gigabytes) of information on a single gram of DNA.
It might be compact, but recording data in the form of a nucleic acid sequence isn't fast. Or cheap.
Last year, Microsoft demonstrated its DNA data storage technology by encoding roughly 200 megabytes of data in the form of 100 literary classics in DNA's four bases in a single process.
According to MIT Review, this process would have cost around US$800,000 using materials on the open market, meaning it would need to be thousands of times cheaper to make it a competitive option.
It was also incredibly slow, with data stored at a rate of about 400 bytes per second. Microsoft says it needs to get to around 100 megabytes per second to be feasible.
It's not clear what efficiencies Microsoft may have found to lower the costs of the process and speed it up, but new technologies have been seeing the cost of gene sequencing drop in recent years, so its end of the decade target may be realistic.
Even then, it's likely it would only be used in select circumstances for customers willing to pay for a specialised storage solution like critical archives of medical or legal data rather than as a replacement for current large-scale storage methods.
But while we're speculating, a somewhat more sci-fi use for DNA-based data storage could one day involve living computers.
While Microsoft's DNA storage solution will be based on chips, there's every possibility that future versions of storage could involve enzymes or bacteria engineered to carry out computations.
Even outside of cells, DNA potentially offers novel ways to compute data, opening ways to rapidly crunch numbers for certain problems much as quantum computers do for other areas of mathematics.
For now, it's looking as if DNA has a solid role to play in solving a very real problem that will only get worse.
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Microsoft plans on storing its data on DNA in the next 3 years ... - ScienceAlert
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Idaho university gets grant to test DNA in convictions – Washington … – Washington Times
Posted: at 7:15 am
BOISE, Idaho (AP) - Convicts who believe they were wrongfully convicted of murder or forcible rape may benefit from a $630,000 federal grant to test DNA.
But none of the money can be used in Idaho cases.
Why? Idaho Attorney General Lawrence Wasden will not sign a federally required form certifying that the states DNA testing and collection practices comply with federal requirements. He told Boise State University that those requirements and Idaho law do not mesh, and that he has no jurisdiction over Idaho law enforcement agencies.
The grant was originally intended for the nonprofit Idaho Innocence Project, which sought it. The project, which focuses on Idaho convictions, is led by criminal justice and biology professor Greg Hampikian.
Since Wasden will not sign the letter, the U.S. Department of Justice agreed to award the grant to Hampikian and Boise State, not to the project. That allows grant money to be used in other states.
Hampikian said he plans to use the grant to work on cases with similar innocence projects in Montana, Georgia, Illinois and other states whose officials agree to sign the form.
NO STATE LAW, NO JURISDICTION
The Idaho Innocence Project was one of just seven organizations in 2016 to receive federal grants under the Justice for All Act enacted in 2004. The grant program, the Kirk Bloodsworth Post-Conviction DNA Testing Program, is named for the first death-row inmate in the U.S. exonerated by DNA evidence.
For the money to be used for DNA testing in any state, the states chief legal officer must sign a one-page form certifying that the state provides post-conviction DNA testing in murder and forcible rape cases and that it preserves biological evidence in those cases.
Wasden said limitations in Idaho law prevent it from meeting the requirements. For example, Idaho law requires preservation of DNA evidence only in sexual assault cases.
There is no similar Idaho statute that applies to testing and preservation of biological cases in the cases of murder, Wasden wrote in an Oct. 13, 2016, letter to Boise State explaining why he would not sign the form.
Furthermore, the form Wasden is asked to sign states, I am aware that a false statement in this certification may be the subject of criminal prosecution. But Wasden said he lacks jurisdiction over any police agencies in Idaho, including the Idaho State Police, and over the state crime lab. He said he cannot certify that all jurisdictions in Idaho take reasonable measures to collect and preserve biological evidence in murder and forcible rape cases.
Some states do have post-conviction DNA collection and preservation laws, and their attorneys general have jurisdiction over state crime labs. For example, in Montana, the attorney general heads the Department of Justice, which includes the state patrol and state crime lab.
Also, Montana has a post-conviction DNA preservation statute, said Toby Cook, an attorney with Montana Innocence Project.
Montana has already sent two DNA cases to Hampikian, one involving sex abuse and one involving the slaying of a bartender.
There was no physical evidence connecting our clients to any of the crimes in either case, Cook said. Instead, their convictions were based on shaky eyewitness testimony and circumstantial evidence.
40 IN THE U.S. EXONERATED
Kirk Bloodsworth was convicted and sentenced to death in 1985 in the rape and killing of a 9-year-old girl in Maryland.
In 1992, Bloodworth learned about new DNA testing. Prosecutors agreed to DNA testing of the victims clothing and other evidence. The DNA did not match Bloodsworths. He was exonerated and released from prison in 1993. After his release, he became an advocate for DNA testing and for abolishing the death penalty.
Idaho filmmaker Gregory Bayne released a documentary in 2015 about the case, Bloodsworth: An Innocent Man.
Forty men and women have been exonerated since the Bloodsworth program started in 2004.
IDAHO PROJECT STILL OPEN
The Idaho Innocence Project is funded by grants and donations. Even though the new grant cannot be used on Idaho cases, Hampikians team will keep working on them.
We are still open for business, Hampikian said. We are not turning away cases.
The project typically handles about a half-dozen Idaho cases at a time.
An earlier grant that can be used on Idaho cases runs out in September. Hampikian thinks additional help may be on the way.
The university is considering earmarking some discretionary funds for support of the Idaho Innocence Project for the next two years, he said.
___
Information from: Idaho Statesman, http://www.idahostatesman.com
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44 ‘hits’ found in DNA testing of old, backlogged Virginia rape … – The Daily Progress
Posted: at 7:15 am
DNA testing in 431 cases of collected but previously untested biological evidence recovered in Virginia rape cases has resulted in 44 DNA database hits.
Hits are when a DNA profile matches a known profile held in the states DNA databaseprimarily the profiles of convicted felonsor matches the DNA profile of an unknown person recovered from another crime.
Officials did not identify the 44 cases Wednesday in a presentation to the Virginia Forensic Science Board. The results are being turned over to law enforcement for possible investigation, said Brad Jenkins, biology manager for the Virginia Department of Forensic Science. It is not known if any crimes have been solved as a result, he said.
Jenkins said Wednesday that the testing has led to roughly 100 profile matches so far, which then resulted in the 44 hits. The majority of those have been to in-state offenders, he said. Officials said nine were for out-of-state offenders. We have not had any case-to-case hits, he said.
The testing is being done under grants sought by DFS and Virginia Attorney General Mark R. Herring, who said last year that the effort would build a stronger DNA database, possibly link crimes together, put away dangerous offenders and help victims.
After the meeting Wednesday, Jenkins said he did not believe all the hits have necessarily reached police. Some are still in the report-writing phase so law enforcement may not know about all of them yet, he said.
Jenkins and Linda Jackson, the departments director, briefed the board Wednesday on developments in the continuing project.In 2015 a statewide inventory of law enforcement agencies by the DFS found that for crimes occurring from 1985 to June 30, 2014, there were nearly 3,000 untested PERKsphysical evidence recovery kitsin their possession that might hold biological evidence that could reveal a suspects DNA profile.
A $1.4 million grant is funding the testing of those kitscollected prior to July 1, 2014from which the 44 hits resulted.
An additional roughly 1,200 untested kits from July 1, 2014 until June 30, 2016when state law required all kits to be submitted for testingwill be tested under another grant, officials said. After June 30, 2016, there should be no further untested kits in light of a recent state law requiring law enforcement to submit the kits to DFS for testing with limited exceptions.
The most common reason cited by law enforcement agencies for not performing DNA testing on evidence was that it was not relevant to the investigation or needed for prosecutionfor example where consent was the suspects defense.
Another often-cited reason was that the victim decided not to assist in the investigation or pursue prosecution.
Jackson said the testing started with the backlogged rape kits from the Fairfax County and Virginia Beach police, the jurisdictions with the most kits to be tested.
Frank Green writes for the Richmond Times-Dispatch.
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