Monthly Archives: May 2017

Extended Space Travel Causes an Inescapable Decrease in Physical Fitness – Gizmodo

Posted: May 9, 2017 at 3:47 pm

Mark Watney, portrayed by Matt Damon, was probably more out of shape than we realized. (Image: The Martian)

Another day, another study showing how awful microgravity is to the human body. In the latest research, scientists have found that long term exposure to space inhibits the movement of oxygen through the body, reducing an astronauts ability to perform strenuous tasks.

New research from Kansas State University shows that prolonged exposure to space reduces an astronauts exercise capacity by 30 to 50 percent. Thats...a lot. As noted in the study, which you can check out at the Journal of Applied Physiology, this seems to be happening because our heart and small blood vessels suck at transporting oxygen to working muscles under microgravity conditions. Discouragingly, the effect still matters when astronauts try to maintain a high degree of fitness in space, by riding stationary bikes and running on treadmills.

For the study, a research team led by kinesiologist Carl Ade looked at NASA data collected for nine male and female astronauts who spent around six months aboard the International Space Station. Prior to embarking on their missions, each astronaut had various health measures taken to assess their physical fitness, including oxygen uptake, cardiac output, and hemoglobin concentration and saturation. (Hemoglobin is the iron-rich protein responsible for transporting oxygen in your blood.) These measures show how effective a persons heart and blood vessels are at getting oxygen to muscle mitochondriathe so-called powerhouses of our cells.

While in space, each astronaut followed an aerobic and resistance training regimen designed by NASA. Moderate and high-intensity aerobic exercise on a bicycle or treadmill was prescribed for four to six days each week, while upper and lower-body resistance training was prescribed six days per week.

Two days after the astronauts returned to Earth, each of them were put through the same battery of physical tests they received prior to launch.

Armed with this before-and-after data, Ade was able to show a 30 to 50 percent decrease in maximal oxygen, which is the maximum rate of oxygen thats consumed during exercise, and a standard measure of cardiorespiratory health. After about 90 days, the astronauts level of fitness returned above 97 percent of what it was before. Their inability to get back to full fitness capacity is likely due to altered function of the lungs following prolonged exposure to microgravity.

It is a dramatic decrease, said Ade in a release. When your cardiovascular function decreases, your aerobic exercise capacity goes down. You cant perform physically challenging activities anymore. While earlier studies suggest that this happens because of changes in heart function, our data suggests that there are some things happening at the level of the heart, but also at the level of the microcirculation within capillaries.

The researchers suspect that microgravity is changing the way blood vessel capillaries interact with red blood cells, but more research is required to suss this out.

For would-be space travellers and Martian colonists, this news undoubtedly sucks. It means that astronauts, after several months of exposure to microgravity, can expect a fairly significant decrease in their ability to perform strenuous tasks. Once on Mars (or other celestial body of choice), an astronaut might be less capable of, say, performing manual labor on the surface. On the plus side, however, this finding alerts scientists to the problem, and they can now go about trying to figure out a solution.

This decrease is related to not only health, but performance, Ade said. If we can understand why maximal oxygen uptake is going down, that allows us to come up with targeted interventions, whether that be exercise or pharmacological interventions. This important new information can help these astronauts and prevent any adverse performance changes in their job.

We can now add reduced oxygen uptake to our ongoing list of crappy things that happen to our bodies when exposed to spaceproblems ranging from loss of bone density and muscle mass through to heart, vision, and back problems. Adapting humans to life beyond Earth, as were learning, is going to be tough.

[Journal of Applied Physiology]

George is a contributing editor at Gizmodo and io9.

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Prolonged Space Travel Affects Astronauts Eyes | Diagnostic Imaging – Diagnostic Imaging

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News | May 08, 2017 | MRI Magnetic resonance imaging shows evidence of changes in the orbital and ventricular fluid volumes among astronauts who participated in prolonged missions on the International Space Station (ISS), according to a study published in the journal Radiology.

Researchers from the University of Miami in Florida performed a retrospective study to determine the respective roles of vascular and cerebrospinal fluids in spaceflight-induced vision impairment in astronauts, known as the visual impairment and intracranial pressure (VIIP) syndrome.

Sixteen astronauts participated in the study, nine who flew on the space shuttle for a mean of 14.1 days and seven who flew on the ISS for a mean of 188 days. Their mean age during their mission was 46.1 years.

All participants underwent MR imaging before flight and again after their return to quantify pre- to post-flight changes in globe flattening and optic nerve protrusion. Automated quantitation was also used to measure pre- to post-flight changes in orbital and ventricular cerebrospinal fluid volumes and in brain tissue volumes. Relationships between individual measures and differences between cohorts were assessed by using correlation and unpaired t test, respectively.

The results showed the pre- to post-flight increases in globe flattening and nerve protrusion were significant only in the long-duration cohort (0.031 0.019 versus 0.001 0.006 and 0.025 0.013 vs 0.001 0.006, respectively). The increases in globe flattening and nerve protrusion were associated with significant increases in orbital and ventricular cerebrospinal fluid volumes. In contrast, brain tissue volumes do not change or correlate with globe flattening and optic nerve protrusion.

The researchers concluded these findings were evidence for a primary role for cerebrospinal fluid and a lesser role for brain volume changes in the formation of VIIP.

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California considers taxing space travel – AOL Finance – AOL Small Business

Posted: at 3:47 pm

Paying taxes on Earth is already a pain, but in California, you could one day be paying that extra fee in space. The state's franchise tax board wants the public to weigh in on the idea.

Its proposal would compute taxes on commercial space transportation companies. Basically, any company operating in California that makes half of their money from space transportation. They say it is any travel 62 miles above the surface of the Earth.

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How much Americans pay in taxes in every state

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Alabama residents pay less in property taxes than residents in any other state due to low median home values and the second-lowest property tax rate. Alabama residents have 23.66 percent of income going toward taxes, with a median household income of $44,509.

Beware health insurance in the state, though. A GOBankingRates study ranked Alabama among the worst states for health insurance costs.

Although the average income tax paid by Alaska residents is higher than the national average, it's largely due to the state's high median income of $75,112. Residents also only pay federal income taxes there is no state income tax. Residents of this oil-producing state pay the least in gas taxes in the nation, at 31 cents per gallon. That helps make Alaska one of the least expensive states to own a car.

Arizona falls in the bottom half of states for total taxes paid by its residents, who see 24.58 percent of their income, on average, go toward taxes. Property taxes and gas taxes paid in this state are lower than the national average.

However, the 8.25 percent sales tax is noticeably higher than the national average of 6.47 percent. Meanwhile, the state was ranked among the worst states to start a business by a GOBankingRates study.

Arkansas has one of the highest sales tax rates in the nation, at 9.3 percent. However, residents pay less in income taxes and gas taxes than the national average. Plus, the average property tax bill in Arkansas is among the lowest in the nation due to low median home values and a low tax rate.

California residents pay more in taxes than residents of most other states. In fact, 31 percent of their income, on average, goes toward taxes. Considering that the cost of living in California also is high, it's no wonder it's one of the states where residents are most likely to live paycheck to paycheck, according to one GOBankingRates study.

Colorado residents pay more in taxes than the national average of $14,998.83 and pay a higher percentage of their income toward taxes, on average. The reason: high income and sales taxes. Gas and property taxes paid in Colorado, on th other hand, are lower than the national average.

Connecticut residents pay more in income taxes than any other state, in part due to a high median income of $72,889. Average property taxes paid in the state also are about double the national average of $2,118.08. In addition to high taxes, residents also are faced with a high cost of living in Connecticut.

Delaware is one of the most tax-friendly states, with residents paying just 21.99 percent of their income toward taxes. One of the key reasons the total tax bill is low here is because there is no sales tax. Plus, the average property tax paid is nearly half the national average.

Washington, D.C., residents pay more in property taxes, on average, than residents in most states due to a high median home value of $540,400. Residents also pay more in income taxes, on average, than any other state, with the exception of Connecticut.

On the plus side, the sales tax rate of 5.75 percent is below the national average. Residents also pay less than the national average to fill up their gas tanks.

Florida is one of seven states with no income tax, so the average income taxes paid here reflect only federal taxes paid. Lower-than-average property taxes also help keep the total taxes paid as a percentage of income to just 21.9 percent in Florida.

The total taxes paid in Georgia are lower than the national average of $14,998.83. However, taxes actually consume a higher percentage of residents' income than the national average because of a low median income of $50,768 in the state.

Hawaii residents have to pay a hefty tax bill to live in paradise. Total taxes paid are among the top 10 highest in the nation due, in large part, to high income taxes. Residents earning a median household income of $64,514 pay around $14,798.36 in income taxes.

On the plus side, property and sales taxes in Hawaii are lower than the national average.

Total taxes paid in Idaho $14,012.17 are slightly below the national average. However, residents pay a higher percentage of their income toward taxes than the national average due to the state's low median income.

Hefty property and sales taxes contribute to a high total tax bill in Illinois. In fact, the average property tax bill is more than 50 percent higher than the national average even though the median home value is below the national average. Overall, Illinois residents pay nearly 30 percent of their income, on average, toward taxes.

Indiana is a relatively tax-friendly state. The average total tax bill is lower than the national average because income and property taxes are lower in Indiana than in most other states.

Total taxes paid in Iowa are higher than the national average because residents pay more in income and sales taxes. Total tax paid as a proportion of income also is higher in Iowa 27.55 percent versus 26.08 percent. However, a 2015 GOBankingRates study found that Iowa is one of the cheapest states for raising a family.

Average property taxes paid in Kansas are relatively low due to a less-than-stellar median home value. Average income taxes paid also are below the national average because of the state's low median wage. However, Kansas residents are hit by a high sales tax, which is 8.62 percent versus the national average 6.47 percent.

Kentucky has the fourth-lowest average tax burden in this study. All taxes paid income, sales, property and gas are well below the national average. Income and property taxes paid are particularly low, on average, due to the state's low median income and property value.

Average property taxes paid in Louisiana are among the lowest in the nation, as are income taxes due to the state's low median income of $45,922. Further, Louisiana has a higher-than-average sales tax of 9.98 percent.

Total taxes paid in Maine are lower than the national average. But that doesn't mean residents don't face high taxes. Total taxes paid consume nearly 27 percent of residents' pay, on average, due to the state's low median income.

Maryland residents pay more in taxes than residents in all but three states. This is largely due to the high income taxes paid in this state, which has the third-highest median income in the nation.

Not only is Massachusetts one of the most expensive states to raise a family, more than 30 percent of what residents earn goes toward income, property, sales and gas taxes. That's a higher rate than all but four states: California, Connecticut, New Jersey and New York.

Michigan's property tax rate is higher than the national average. However, a low median home value helps keep down the average property taxes paid in the state. Income and sales taxes paid also are lower than the national average.

On average, nearly 30 percent of what Minnesota residents earn goes toward income, property, sales and gas taxes. Average income taxes paid are particularly high, compared with other states.

Mississippi residents pay the lowest total tax bill in the nation. Income taxes paid here are the second lowest in the country due to the state's low median income of $40,037. Plus, property taxes paid are among the lowest in the nation as a result of a low tax rate and median home value.

The total tax bill in Missouri is only slightly higher than the national average of $14,998.83, due to income and sales taxes that are higher than the average paid nationwide. However, property and gas taxes in Missouri are well below the national average paid.

Montana is just one of four states with no sales tax. Property and income taxes also are lower than the national average. As a result, Montana residents see just 22.28 percent of their income, on average, go toward taxes.

The total tax bill in Nebraska is higher than the national average. In large part, it's because residents pay more in income taxes as a result of a higher-than-average median income. Nonetheless, residents pay, on average, an amount equal to about 28 percent of their income.

Nevada has no state income tax, which explains why the state's total tax bill is among the lowest in the nation. However, residents are hit with a 7.98 percent sales tax, which is among the highest in the nation. If you're looking to buy a home in Nevada, best sure to check out Reno. It is the best city to buy a house in Nevada.

New Hampshire has no sales tax. It also doesn't have a state income tax, but the average amount of federal income taxes paid by residents is high because the state has the highest median income in the nation. Residents also pay more in property taxes than the national average paid. In fact, New Hampshire has the second-highest property tax rate in the U.S., after New Jersey.

New Jersey residents pay the highest total tax bill in the nation. They also pay the highest percentage of income toward taxes 33.17 percent, on average. The biggest reason the tax burden is so high in New Jersey is the state's 2.13 percent property tax rate, which is more than twice as high as the national average rate.

Total taxes paid in New Mexico are among the lowest in the nation. Property and income taxes paid are well below the national average. This is due, in large part, to a low median income and a low median home value in the state.

Like their New Jersey neighbors, New York residents pay more than 30 percent of their income toward taxes. Residents pay a lot on the state's high sales tax of 8.49 percent and property tax of 1.38 percent.

The total tax bill in North Carolina is lower than the national average thanks to lower-than-average property and income taxes. However, residents pay more in gas taxes.

North Dakota residents have a lower total tax bill than the national average, paying around $13,381.61 every year. Gas and property taxes are lower than the national average, too.

Although the property tax rate in Ohio is higher than the national average, property taxes paid fall below the national average due to the state's low median home value of $125,300. Ohio residents also pay slightly less in income taxes overall, forking over just under $9,000 annually.

Oklahoma has one of the lowest total tax bills in the nation. Income and property taxes are well below the national average because median income and the median home value are among the lowest in the U.S. However, residents are hit by a high 8.86 percent state sales tax.

Oregon is just one of four states without a sales tax. Still, residents pay just over 28 percent of their income toward taxes. They face a high income tax bill.

At 77 cents per gallon, the gas tax in Pennsylvania is the highest in the nation. Property and income taxes in this state also are higher than the national average. If that wasn't bad enough, the state is also home to one of the worst cities in the U.S. for investment properties Pittsburgh.

Rhode Island residents pay over 29 percent of their income toward taxes. The big tax bite is due primarily to the state's high property tax rate of 1.51 percent. Income and sales taxes, on the other hand, are on par with the national average.

South Carolina's total tax bill is among the lowest in the nation. Residents pay below-average income, gas and property taxes. Its sales tax, however, is above average at 7.22 percent.

South Dakota has no income tax, which helps keep residents' total tax bill below the national average. Property and sales taxes paid also are slightly below the national average.

Tennessee has no state taxes on income, but it makes up for it with a high sales tax rate of 9.46 percent the second highest in this study. The average property taxes paid, on the other hand, are half the national average.

The total tax bill Texas residents pay is lower than the national average because residents don't pay state income tax. And they pay lower gas taxes than residents in most states. It's no surprise then that cities like Plano, Lubbock and Austin rank among the best cities to live in when you're saving money.

The overall tax bill in Utah is higher than the national average due to high income taxes paid by residents. However, the state does offer a high median household income of about $66,000. Meanwhile, the state's property tax rate is just 0.64 percent, compared to the national average of 1.02 percent.

Vermont residents pay more in property taxes than residents in most other states. As a result, total taxes paid in this state nearly top $18,000, far higher than the national average.

Virginia residents have a higher income tax bill than the national average, paying just over $12,600. But it's due, in part, to the state's median income, which is higher than the national average. Sales, gas and property taxes are all lower than national averages.

Washington has no income tax. However, residents are liable to pay a lot in income taxes thanks to the state's high median household income of $67,243. The state sales tax is also high, at 8.92 percent.

The total tax bill in West Virginia is the second lowest in the nation, after Mississippi. The typical property tax bill is also the second lowest in the nation, due to the state's low property tax rate of 0.53 percent and a low home value of $102,400.

Wisconsin residents pay a higher overall tax bill than the national average because of the state's high income and property taxes. In fact, Wisconsin is among the top 10 states that take the most out of your paycheck.

Residents of this tax-friendly state pay only about 20 percent of their income toward taxes the lowest percentage in the nation. Wyoming has no state income tax, and property and sales taxes in the state are well below national averages.

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Now, the reason the board created the rules is to let entrepreneurs know the state's tax code will be ready once business takes off. And, figuring out the amount of tax is actually pretty simple. The farther away from Earth you go means the less tax you pay. While the closer you are means more tax.

A public hearing on the rules is set for June 16th.

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Singularity University Launches Smart City Accelerator in Columbus, Ohio in Partnership with American Electric Power … – PR Newswire (press release)

Posted: at 3:46 pm

"The SU Smart City Accelerator will attract innovators from around the world and amplify the successes Columbus already has achieved in becoming recognized as a global center of technology and innovation," said Mayor Andrew J. Ginther. "I view the SU Smart Cities Accelerator as a mutually supportive partner and participant of Smart Columbus, and I look forward to working with Singularity University on this transformative initiative."

"When Columbus won the U.S. Department of Transportation Smart City Challenge, Singularity University wanted to be part of and contribute to the innovation ecosystem here," said Singularity University Vice President of Corporate Innovation, Nick Davis. "One of the primary goals of Smart Columbus is to support the local entrepreneurial environment, expose local corporations and entrepreneurs to cutting-edge ideas from other cities, and provide the foundation for a sustainable link between Columbus and other innovation hubs across the world."

Startups, ranging from early-stage companies with a working prototype of their products to those beginning to grow their revenue, can learn more and apply online at su.org/sca. Singularity University Accelerators are differentiated in the market by their focus on exponential thinking and technologies, as well as by the commitment SU makes to supporting innovation over the long term.

"We are committed to giving the innovators and entrepreneurs who participate in this world-class accelerator program full access to our community as a living laboratory so that we can learn together what business models and technologies are going to make our cities better in the future for all people," said Alex Fischer, President and CEO of the Columbus Partnership, representative of the region's business leadership and the entity co-leading Smart Columbus alongside the City of Columbus. "There is unprecedented investment and commitment by local and national industry leaders to demonstrate in Columbus what the future can be for mid-size cities, the most prevalent city size in the world. We are proud to have SU joining the team as we embark on this journey."

The SU Smart Cities Accelerator will choose 10 businesses focused on one or more of the following:

SU will provide help accessing Singularity University faculty and programs, identify mentors from large companies and startups across the globe to provide expertise on industry and technology, and assign mentors to the team for which their expertise will be most valuable. Other sponsors will facilitate web services, legal support, financial services, and tax planning for the ten businesses.

With Singularity University's support, Columbus will have the opportunity to integrate West Coast innovation concepts into its existing networks. Over the past decade, business accelerator programs tailored to the unique strengths of a given community have emerged as key engines for generating innovation, new businesses and new jobs.

"Bringing the Singularity University (SU) Smart City Accelerator to Columbus is a catalyst for innovation and technology in Columbus, and AEP is proud to be a part of it," said AEP CEO Nick Akins. "In fact we so believe in the benefits of SU's Smart City Accelerator that we are sending an AEP team through it. The vision of Smart Columbus is for this community to be a center of innovation and entrepreneurship, and the SU Smart City Accelerator represents a significant step toward the realization of that vision."

"This accelerator will empower entrepreneurs to leverage breakthroughs in technology, from autonomous vehicles to efficiencies made possible by object awareness, to enhance lives and improve standards of living," said Rich Langdale, Managing Partner, NCT Ventures. "The Smart Cities initiative is more than a challenge. Civilization is at a turning point and Columbus has the opportunity to promote innovation and pioneer what it means to live in a smart city of the future."

Organizations to Benefit from Supporting Smart Columbus Accelerator

Partners and sponsors of the SU Smart City Accelerator can also benefit from getting involved beyond raising awareness and linking their brands to thought leadership and innovation. Sponsoring companies can choose to develop new products outside their traditional - often slower - R&D processes and gain the help of outside experts and resources. They will also get a first look at the most cutting-edge startups as well as possible market disruptions these startups represent, helping them to formulate better strategies for their own futures. Sponsors and partners will gain full access to all accelerator classes and presentations from subject matter experts in all areas around smart city technologies and innovation. Companies outside Columbus will gain invaluable access to the city's existing corporate, industry and academic expertise, while local startups will benefit by forging critical relationships with entrepreneurs and thought leaders from across the country.

To learn more about how local businesses, organizations and individuals can get involved in the SU Smart Cities Accelerator as a sponsor, partner, mentor, or by investing resources, expertise or other in-kind support go to su.org/sca.

About Smart Columbus

As the sole winner of the U.S. Department of Transportation's (USDOT) Smart Cities Challenge, Columbus was awarded funding and designated America's Smart City; but more importantly it also won the coveted job as global teacher for cities around the world on how to "become Smart" by embracing the reinvention of transportation to accelerate human progress. Columbus received a total of $50 million in the form of two grants: $40 million from USDOT and $10 million from Vulcan, Inc., a Paul Allen company. These dollars provide the seed funding for Smart Columbus, a region-wide Smart City initiative co-led by the City of Columbus and Columbus Partnership. The City of Columbus, under the leadership of Mayor Andrew J. Ginther, is the lead recipient of the $50 million and will administer the deployment of these funds for the duration of the grant period, which concludes at the end of 2020. The Columbus Partnership, representing the Columbus Region's private sector, is the lead implementation partner for the grant program and is responsible for the initiative's Acceleration Fund, which is credited as a significant factor in Columbus' winning of the challenge. The Acceleration Fund, which started out as $90 million now totals more than $360 million and is composed of coordinated and aligned investments by the private sector to complement, scale, and sustain Smart Columbus projects and programs. This number will continue to increase as new partnerships are formed with companies like Singularity University to reach the goal of $1 billion by 2020.

About AEP

Headquartered in Columbus, American Electric Power is one of the largest electric utilities in the United States, delivering electricity and custom energy solutions to nearly 5.4 million customers in 11 states. AEP owns the nation's largest electricity transmission system, a more than 40,000-mile network that includes more 765-kilovolt extra-high voltage transmission lines than all other U.S. transmission systems combined. AEP also operates 224,000 miles of distribution lines. AEP ranks among the nation's largest generators of electricity, owning approximately 26,000 megawatts of generating capacity in the U.S. AEP supplies 3,200 megawatts of renewable energy to customers.

About NCT Ventures

NCT Ventures is a Columbus-based venture capital firm dedicated to providing a platform for entrepreneurs to succeed in turning their ideas into profitable business models through hands-on operational support. Over the last 20 years, NCT has helped build many successful companies across a variety of industries. NCT empowers entrepreneurs to develop disruptive technologies that improve market efficiencies. For more information, visit http://www.nctventures.com/.

About Singularity University

Singularity University is a global learning and innovation community using exponential technologies to tackle the world's biggest challenges and build an abundant future for all. SU's collaborative platform empowers individuals and organizations across the globe to learn, connect, and innovate breakthrough solutions using accelerating technologies like artificial intelligence, robotics, and digital biology. SU was founded in 2008 by renowned innovators Ray Kurzweil and Peter H. Diamandis and is partnered with leading organizations including Google, Deloitte, Genentech, and UNICEF. To learn more, visit SU.org, join us on Facebook, and follow us on Twitter @SingularityU.

Media Contacts:Dan Williamson 614-593-9510 dwilliamson@paulwerth.com

Anna Roubos 774-232-2460 anna.roubos@ogilvy.com

Melissa McHenry 614-716-1120 mmchenry@aep.com

Calvin Cooper (614) 794-2732 calvin.cooper@nctventures.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/singularity-university-launches-smart-city-accelerator-in-columbus-ohio-in-partnership-with-american-electric-power-and-nct-ventures-to-support-entrepreneurship-300453027.html

SOURCE Singularity University

https://su.org

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Singularity University Launches Smart City Accelerator in Columbus, Ohio in Partnership with American Electric Power ... - PR Newswire (press release)

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Silicon Valley Think Tank Assists Smart City Initiative in Columbus, Ohio – Government Technology

Posted: at 3:46 pm

(TNS) -- Singularity University, a Silicon Valley think tank and business incubator, announced Monday it is sponsoring a Smart City Accelerator in Columbus.

The accelerator would be the first program of its kind and is in response to Columbus winning the U.S. Department of Transportation's Smart City Challenge.

The accelerator will help the businesses involved in the program by providing access to Singularity University faculty, and by identifying mentors from large companies and startups who will provide expertise on industry and technology.

Other sponsors will facilitate web services, legal support, financial services and tax planning for the chosen businesses.

After Columbus won the Smart City Challenge, Singularity University wanted to be part of the local entrepreneurial environment, said Nick Davis, Singularity University vice president of corporate innovation, in a statement. The Smart City Accelerator "will drive the next wave of innovation," with the ultimate goal of creating better functioning cities that transform how residents and communities work and live.

Last June, Columbus bested six other finalists in the U.S. Department of Transportation's Smart City competition to receive $50 million in grants from the federal government and Vulcan Inc. to develop the city into the nation's proving ground for intelligent transportation systems. The city also lined up about $90 million in local matching commitments, including $19 million in public money, giving Columbus a total of $140 million to upgrade its transportation network.

Singularity's Smart Cities Accelerator will choose 10 businesses focused on such things as mobility; connectivity; data and analytics; infrastructure and energy; and manufacturing and production.

Each selected business will be eligible to receive up to $100,000 in funding from Columbus-based venture capital firm NCT Ventures.

"The (Singularity) Smart City Accelerator will attract innovators from around the world and amplify the successes Columbus already has achieved in becoming recognized as a global center of technology and innovation," said Mayor Andrew J. Ginther in a statement. "I view the ... Smart Cities Accelerator as a mutually supportive partner and participant of Smart Columbus, and I look forward to working with Singularity University on this transformative initiative."

The program will be a "world-class accelerator," said Alex Fischer, president and CEO of the Columbus Partnership, which represents the region's business leadership and is leading the Smart Columbus effort alongside the city of Columbus. By giving the entrepreneurs who participate in the program "full access to our community as a living laboratory ... we can learn together what business models and technologies are going to make our cities better in the future for all people," Fischer said.

Singularity University was co-founded in 2008 by inventor and futurist Ray Kurzweil and Peter H. Diamandis, the entrepreneur best known for being the founder and chairman of the X Prize Foundation, the non-profit that encourage technological development to benefit mankind.

The benefits of the Smart City Accelerator program are expected to be so strong that American Electric Power is already planning to send a team through it, said AEP CEO Nick Akins.

"Bringing the Singularity University Smart City Accelerator to Columbus is a catalyst for innovation and technology in Columbus," Akins said in a statement. "The vision of Smart Columbus is for this community to be a center of innovation and entrepreneurship, and the Smart City Accelerator represents a significant step toward the realization of that vision."

2017 The Columbus Dispatch (Columbus, Ohio) Distributed by Tribune Content Agency, LLC.

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Smart City Accelerator to give Columbus ‘a huge leap forward on the international stage’ – Columbus Business First

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May 8, 2017, 3:02pm EDT

The Columbus Smart City more

Columbus Chief Innovation Officer Michael Stevens discussing the city's Smart Columbus more

Rick Titus

Columbus is inviting tech startups nationwide and globally to compete for slots in the Smart City Accelerator, and leaders say whether the resulting companies stay in Central Ohio or not, they'll benefit economic development and further establish the region as an innovation hub.

Columbus Chief Innovation Officer Michael Stevens discussing the city's Smart Columbus more

Rick Titus

Columbus is inviting tech startups nationwide and globally to compete for slots in the Smart City Accelerator and leaders say whether any resulting companies stay in Central Ohio or not, they'll benefit economic development and further establish the region as an innovation hub.

Silicon Valley-based Singularity University will operate the business accelerator program this fall for teams making industry-changing technology in energy, transportation, manufacturing and other aspects of urban life. Columbus venture capital firm NCT Ventures is investing up to $100,000 each in the 10 participants. They'll also have at their disposal a city-curated trove of data called the Smart City Sandbox.

Columbus Chief Innovation Officer Michael Stevens discussing the city's Smart Columbus more

Rick Titus

"By attracting the best startups from around the world to the region, we are taking a huge leap forward on the international stage," Nick Davis, Singularity vice president of corporate innovation, said via email.

Startups completing the business curriculum and refining their products in the accelerator could produce technology that benefits Central Ohio even if they leave the area after the program, said Michael Stevens, Columbus' chief innovation officer.

The long-term benefit is you will see more companies coming here and continuing to invest here and provide jobs and opportunity, Stevens said.

Davis, who splits his time between Silicon Valley and Columbus, is a founding partner in a separate organization that operates startup accelerators. Hes had a few years to watch and participate in the maturing of Central Ohios entrepreneurial sector. Its at a point where it needs even more incubation and an acceleration program, he said, as well as sources of capital.

Over the last several years the local accelerators have gained in momentum and sophistication just like the overall startup ecosystem in Columbus, he said. As more quality startups are formed there is a relational increase in funding to support them.

What is great now is to see the variety of accelerators and multiple players in town delivering these valuable programs to startups and for the community, he said.

No funding from the city or the Smart City federal grant goes to the accelerator, although the 10 startups will be aligned with goals of the program, Stevens said. Columbus-based American Electric Power Company Inc. (NYSE:AEP) is the lead operations sponsor. Other entities are helping with mentors and business services.

Technologies sought for the program are ways to bring old-school industries like manufacturing and transportation into the future.

Those industries are still important, and weve got to make sure were adapting to the change thats coming fast, and make sure were not left behind, Stevens said.

The Columbus Smart City more

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Smart City Accelerator to give Columbus 'a huge leap forward on the international stage' - Columbus Business First

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TMG 2010 rewriting original host headers when … – Extropy

Posted: at 3:45 pm

I found a strange behavior with TMG 2010 when publishing a website. It appears to rewrite URLs sent outbound to clients when the "send original host header is sent" under certain conditions. Here are those conditions:

Here is precisely what I encountered:

So by process of elimination I found that this appears to be TMG not affecting any host header inbound, nor affecting the alternate URLs outbound.This appears to affect only the main URL outbound, as TMG appears to be rewriting the protocol part of the header when the submitted form returns a redirect from http to https (changing https back to http).

Fixes: Uncheck the "send original host header..." flag and all functionality works correctly. I don't think this is as "clean", because it means that TMG touches every request and changes the host header to the internal host header, however on the IIS bright-side this means the web server will see the same host header no matter what clients request (normalization). The only caveat is that if you wanted to use an internal URL (instead of IP address) for the site that was the same as the external URL it would either not work, or would require a DNS trick on TMG to force it. Or, you could just change the internal URL to something else (not used).

TMG proxy background:

This isn't so much of a bug in TMG as a "feature". TMG is designed to allow external access to internal resources. I've found that it makes a powerful and flexible reverse proxy server, you just have to contend with a few "features". TMG's basic design-premise is based on rewriting URLs that are normally only internally visible, to URLs that are externally visible. This means that TMG errs towards the side of rewriting in exception cases, which this appears to be. This methodology appears to assume that the web servers are dumb, and don't know about external URLs. This premise is fine, except when it is necessary for the web server to perform some type of functionality that requires a complex redirect based on a user action (such as switching to https when a user logs in). TMG assumes that the redirect is internal in nature and blocks the redirect in favor of maintaining the original URL and same-protocol bridging (or more accurately not bridging). This appears to only be an issue when TMG is confused by using the external URL as the internal URL (same as listener and client requests). This shouldn't be an issue when you specify that TMG uses an IP address for the internal site, however it appears that MS has designed TMG to be "smarter" and "more helpful" by performing host header translation outbound, even when you request it no to do so...

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TMG 2010 rewriting original host headers when ... - Extropy

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Ascension to flush out water system with chlorine burn – WBRZ

Posted: at 3:44 pm

ASCENSION Thousands of Ascension Parish residents could see some changes to their water as the parish is flushing out its system with chemicals.

Starting on Monday, the west side of Ascension Parish could see discoloration, a possible odor or maybe even a different taste in their water. It's all part of a chlorine burn.

"We are flushing the system with a disinfectant that we call free chlorine, and that's called the burn. The system is being flushed out, it's just a routine maintenance that we regularly do to provide the people with a level of service that they have grown accustomed to," Martin McConnell, Ascension Parish public information officer, said.

The burn is recommended every two years. The time span for the burn is expected to last for thirty days. Parish officials say the visual side effects of the burn can be easily eliminated.

"What we are recommending to them to do is if they do notice any of those things, just let the tap run for a little bit, and soon enough fresh water will be coming out," McConnell said.

The possible smell that residents may experience is strictly based on proximity, officials say.

"That smell is probably going to be stronger the closer you are to the production plant. As you get further out along the water system, the smell should dissipate, and virtually disappear," McConnell said.

All remnants of the burn should be gone by early June. Ascension Parish officials stressed the water is safe to drink, however if residents experience medical complications, they should consult a doctor.

The parish added that discoloring in laundry is also possible.

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"Casual"set-piece defense limiting Chicago Fire’s ascension in the East – MLSsoccer.com

Posted: at 3:44 pm

CARSON, Calif.The Chicago Fire, undefeated at home in 2017, have struggled away from the friendly confines of Toyota Park this season, one of six MLS clubs without an away victory. And in what could be an ascendent season, the Fire's success let alone on the road depends on improving set-piece defense.

At StubHub Center on Saturday against the LA Galaxy, Chicago scored two early first-half goals, and looked to be in total control of the match. But LA came roaring back in the second half, their increased intensity putting a relaxed Chicago back on its heels. LA equalized off two corner kicks, securing a point in the 2-2 draw.

In the second half, I think we came a little too casual in one of our strengths, which is our defensive set pieces, said Fire head coach Velkjo Paunovic.

Out of the 14 goals Chicago has given up so far this season, four have been off set pieces all on the road.

The Fire admittedly eased off the pedal, leaving room for miscues and blown assignments.

Maybe we thought the game was done, said Bastian Schweinsteiger. We spoke about it on half-time. That was not the case. We didnt find the free man, we rushed, we lost the ball too easy, then you lose a little bit of the control of the game.

Chicago will get a reprieve from the road, with only two matches away from Toyota Park in the next month. But they face both the Seattle Sounders and Orlando City in the next few weeks, and each of those teams has scored a significant percentage of their goals off set pieces.

Midfielder Juninho knows that Chicago has to take the lessons from Saturday night. And it starts with the obvious:

Unfortunately, we let in two goals from set pieces. Now, we just have to work hard and take it game-by-game.

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"Casual"set-piece defense limiting Chicago Fire's ascension in the East - MLSsoccer.com

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Nanotech ‘slingshot’ shoots drugs right where they’re needed – CBC.ca

Posted: at 3:43 pm

A group of Canadian and Italian scientists hasdeveloped a nano-scale "slingshot" that can shoot drugs directly to the part of the body that needs them, thereby speeding up recovery and reducing side-effects.

This idea addresses one of the most taxing problems in medicine: how to kill diseased cells while preserving healthy ones.

Scientists have for many years been working on improving therapies like chemo and radiation on that score, but most efforts have focused on modifying the chemistry rather than alteringthe delivery of the drug.

"It's all about tuning the concentration of the drug optimally in the body: high concentration where you want it to be active, and low concentration where you don't want to affect other healthy parts," says Prof. Alexis Valle-Blisleof the University of Montreal, co-author of the report published this week in Nature Communications.

"If you can increase the concentration of that drug at the specific location, that drug will be more efficient," he told CBC News in an interview.

Restricting the movement of the drug also reduces potentially harmful secondary effects on other parts of the body for instance, the hair loss that can result from toxic cancer treatments, or the loss of so-called good bacteria due to antibiotic use.

The idea of the slingshot is to home in on the target cells at a molecular level.

Valle-Blisle and his colleagues from U of M and the University of Rome Tor Vergata say they can build a synthetic strand of DNA just a few nanometres long (a nanometre is one-billionth of a metre) that will activate only when it binds to a specific disease marker it has been programmed to identify, like an antibody.

Alexis Valle-Blisle is a professor at the University of Montreal and heads up the school's Laboratory of Biosensors & Nanomachines. (University of Montreal)

The two ends of the strand anchor themselves to the antibody, stretching the strand taut and catapulting the drug to its target.

"Imagine our slingshot like a weapon, and this weapon is being used by our own antibody," said Valle-Blisle, who heads the Laboratory of Biosensors & Nanomachinesat U of M. "We design a specific weapon targeting, for example, HIV. We provide the weapon in the body with the bullet the drug. If the right solider is there, the soldier can use the weapon and shoot the problem."

Equally important: if the wrong soldier is present, the weapon won't be deployed.

So rather than delay treatment for an unidentified infection that could be either viral or bacterial, a patient could receive the medicationfor both and their body would only use the one it needed.

The approach could work with a wide range of drugs aimed at a variety of diseases antibodies are produced in response to many different conditions, including viral and bacterial infections, allergy, cancer and autoimmune diseases like Type 1 diabetes and lupus.

And it can be adapted for other types of disease markers.

But Valle-Blisle and his team are chemists, not clinicians, and their development is so far only a "proof of principle." They intendto work with doctors and other researchers to figure out which diseases to target and which drugs might work best using this delivery system.

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Nanotech 'slingshot' shoots drugs right where they're needed - CBC.ca

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