Daily Archives: April 19, 2017

Reduction of Post -Traumatic Stress Symptoms Associated with Non-Invasive Neurotechnology – Newswise (press release)

Posted: April 19, 2017 at 10:13 am

Newswise WINSTON-SALEM, N.C. April 19, 2017 A closed-loop acoustic stimulation brainwave technology significantly reduced symptoms in people suffering from post-traumatic stress in a small pilot study conducted at Wake Forest Baptist Medical Center. The study is published in the April 19 online edition of the journal BMC Psychiatry.

The effects of chronic stress are killing people and the medical profession has not yet found an answer for how best to treat them, said Charles H. Tegeler, M.D., professor of neurology at Wake Forest School of Medicine, a part of Wake Forest Baptist. We believe there is a need for effective, non-invasive, non-drug therapies for symptoms of post-traumatic stress, which is why we conducted this trial.

Nineteen volunteers who reported high scores on the Post-traumatic Stress Disorder Checklist, civilian version (PCL-C), a commonly used symptom inventory, were included in this single-site study. Of those, 18 completed an average of 16 sessions over a total of 16.5 days, with eight days of actual visits to the office, Tegeler said.

The intervention, high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), focused on the brain, which is the organ of central command for managing responses to threat and trauma. Participants received a series of HIRREM sessions in which brain electrical activity was monitored noninvasively at high spectral resolution with software algorithms translating selected brain frequencies into audible tones in real time. Those tones were reflected back to participants via ear buds in as little as four milliseconds, providing the brain an opportunity for self-optimization of its electrical pattern.

As a closed-loop neurotechnology, the process did not require any conscious, cognitive activity by the participant, who merely relaxed and listened to the tones.

Its as if the brain can look at itself in an acoustic mirror, recalibrate its patterns towards improved balance and reduced hyperarousal, and can relax, Tegeler said. HIRREM was developed by Brain State Technologies based in Scottsdale, Arizona, and has been licensed to Wake Forest Baptist for collaborative research since 2011.

Participants completed the PCL-C, and 12 also had continuous recording of blood pressure and heart rate, before and after the intervention sessions. Changes in temporal lobe high frequency asymmetry were analyzed from baseline assessment through the first four sessions, and again for the last four sessions. Autonomic cardiovascular regulation was evaluated with analysis of heart rate variability and blood pressure modulation before and after the intervention.

After the sessions, 89 percent (16 of 18) of the participants reported clinically meaningful decreases in symptoms of post-traumatic stress as indicated by a change of at least 10 points from their baseline PCL-C score, Tegeler said. In the entire study group, the average reduction in the PCL-C score was 24 points. There were no adverse events reported.

There is ample scientific evidence that there is some brain asymmetry associated with chronic stress. This study is important because it also showed that there was improved balance in brain pattern activity and significant improvement in the autonomic nervous system function, as measured by heart rate variability and blood pressure modulation. All are relevant to a state of chronic stress, which now seems to affect so many people, Tegeler said.

Study limitations included the case series design and the absence of a control group. Additionally, participants were selected based on self-reported symptoms and on the PCL-C score rather than a formal clinical assessment.

The study was supported by a grant from The Susanne Marcus Collins Foundation, Inc., to the Department of Neurology at Wake Forest Baptist.

Co-authors include: Jared F. Cook, M.A., Catherine L. Tegeler, B.S., Joshua R. Hirsch, B.S.E., Hossam A. Shaltout, Ph.D., Sean L. Simpson, Ph.D., Brian C. Fidali, B.A., of Wake Forest Baptist; and Lee Gerdes and Sung W. Lee, M.D., of Brain State Technologies.

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Academia, industry collaborate on solutions to neural disease, injury – Medical Xpress

Posted: at 10:13 am

April 17, 2017

Neurological disorders like Parkinson's, the aftermath of stroke, limb loss and paralysis significantly diminish the length and quality of lifeaffecting about one in six people worldwide. But a growing number of biomedical innovations, driven in large part by an aging population dealing with debilitating health issues, are improving both cognitive and motor function.

A new National Science Foundation (NSF) Industry/University Cooperative Research Center (I/UCRC) will focus on developing and testing new neuraltechnologies with the potential to dramatically enhance patient function across a wide range of diseases and injuries while both lowering costs and increasing accessibility.

The BRAIN Center (Building Reliable Advances and Innovation in Neurotechnology) will be led by researchers from Arizona State University and the University of Houston and, working with industry partners, will speed technologies to market.

BRAIN will focus on developing and testing neurotechnologies designed to address a wide range of sensory, motor and cognitive functions. Such neuraltechnologies could save an estimated $400 billion in future costs, according to the U.S. Centers for Disease Control and Prevention.

"The BRAIN Center is a way to bring together top faculty at both institutions to address critical challenges in the biomedical field," said Jose Luis Contreras-Vidal, professor of electrical and computer engineering at UH. "The best way to do that is working with industry."

Contreras-Vidal and Marco Santello, director of ASU's School of Biological Health Sciences, will lead the project, which involves more than 50 researchers from both institutions, along with 14 members from industry, including several hospital systems. The researchers come from a wide range of disciplines, from engineering to law, data science and physiology. More information is available on the center websites, https://brain.engineering.asu.edu/research/ and http://brain.egr.uh.edu/

"Medical advances have dramatically increased life expectancy in the 21st century," said Santello. "The BRAIN Center will enable us to develop safe, reliable neurotechnologies to address the rise in chronic, degenerative diseases associated with an aging population."

The BRAIN Center was launched with a $1.5 million grant from the National Science Foundation, shared equally by the universities; industry collaborators pay $50,000 a year to partner with faculty, using university laboratories to co-develop and validate new technologies.

With dedicated space on both campuses, the center will host two meetings a year, starting with a summer meeting in Phoenix and a second meeting in Houston this fall. Industry/faculty teams will present proposals for developing collaborative research projects. Research areas range from Big Data to neurorehabilitation and neuromodulation device development, to robotic-assisted therapy and regulatory science.

The NSF grant also includes a workforce training component, with a focus on recruiting and training students from underrepresented communities in undergraduate programs.

"We are training the next workforce," said Contreras-Vidal. "The technology is so new, we don't have enough people to design, repair, validate and prescribe these technologies."

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Failed CF Drug Firm Nivalis to Merge with Immunotherapeutics Specialist Alpine – Genetic Engineering & Biotechnology News

Posted: at 10:12 am

Seattle-based immunotherapeutics firm Alpine Immune Sciences has agreed to a merger with Nivalis Therapeutics, which has been evaluating potential strategic alternatives since January this year, after its lead cystic fibrosis (CF) drug cavosonstat failed Phase II evaluation.

The stock-based transaction to combine the firms will see Alpine merged with a wholly owned Nivalis subsidiary. The joint entity will retain the Alpine Immune Sciences name and will be owned 74% by Alpine shareholders, with Nivalis stockholders owning the remaining 26%, based on a Nivalis valuation of $50 million, which includes the latters projected cash pot of $44 million.

The merged Alpine Immune Sciences business is expected to start out with approximately $90 million in cash and cash equivalents and will focus on exploiting Alpines vIgD (variant immunoglobulin domain) platform to develop engineered immune system proteins against inflammatory and autoimmune disorders and cancer.

Alpines current executive chairman and CEO Mitchell H. Gold, M.D., will head the merged company as chairman and CEO, and an expanded board of directors will seat two Nivalis representatives.

Dr. Gold described the merger as a unique opportunity to accelerate the development of its immunotherapy platform. We look forward to building on our early success by taking multiple novel programs into the clinic to help patients with significant medical needs, he said in a statement.

Alpine was founded in 2015 to develop a pipeline of vIgD-engineered immunotherapeutics that target the immune synapse. The firm is also leveraging the vIgD technology through its TIP (transmembrane immunomodulatory protein) program, which aims to enhance engineered cellular therapies (ECTs), including chimeric antigen receptor (CAR) T-cell, T-cell receptor (TCR), and tumor infiltrating lymphocyte (TIL) therapeutics. In October 2015, the firm inked a potentially $535 million deal with Kite Pharma to develop two Transmembrane Immunomodulatory Protein (TIPTM) programs into CAR and TCR product candidates.

Nivalis confirmed in November 2016 that the S-nitrosoglutathione reductase (GSNOR) inhibitor cavosonstat had failed in its first Phase II study, and at the start of January the Colorado-based firm announced that it was reviewing potential strategic alternatives. The firms then president and CEO Jon Congleton and CMO David Rodman, M.D., stepped down later in January as part of a cost-cutting restructuring exercise through which the firm said it would lose 25 of its 30-strong workforce, including the two executives. Six weeks after the restructuring announcement, Nivalis reported that cavosonstat had failed in a second Phase II CF study.

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FC Bayern Munich fume over Champions League ‘robbery’ by Real Madrid CF – Hindustan Times

Posted: at 10:12 am

Real Madrid, powered by a hat-trick byCristiano Ronaldo, won 4-2 after extra time to progress to the UEFAChampions League semifinals on Tuesday.

FC Bayern Munich left the Santiago Bernabeu furious with referee Viktor Kassai and his team of assistants after being knocked out of the UEFAChampions League by Real Madrid C.F. on Tuesday.

Real Madrid won 4-2 after extra-time to advance with a 6-3 aggregate success but Cristiano Ronaldo was offside for two of his three goals and a harsh dismissal for Arturo Vidal left a fuming Bayern with 10 men.

Chile midfielder Vidal was shown a second yellow card by Kassai in the 84th minute for what appeared a clean challenge on Marco Asensio, tilting the game in Madrids favour as they entered extra-time trailing 2-1.

Read more | Cristiano Ronaldo urges Real Madrid fans: Stop whistling me!

Ronaldo scored the next goal in the 105th minute from a clear offside position, and then sent Madrid 3-2 up on the night when fractionally offside.

When they rob a game from you like that, its very tough. This error cant happen in the Champions League, said Vidal.

When it was 2-1 they got scared and the referee started putting on his show. We played with one less man at home and here, too. The referee put us out of the Champions League.

Read more | Perhaps they wont boo him anymore: Real Madrid coach Zidane backs Cristiano Ronaldo

There were other contentious decisions on the night, including Casemiro avoiding a red card for a late foul on Bayerns Arjen Robben when already booked and an offside against Robert Lewandowski in the second half when the Polish striker was well placed.

Its very harsh, two offside goals, the red card for Casemiro before mine, said Vidal.

The dressing room is very sad because we really wanted to go through but we have to keep improving and hope these things will not happen again.

Were very angry, a game with that much intensity cant be decided by the referee.

Read more | Atletico Madrid prove fairytale killers, end Leicester City F.C. run inChampions League

Bayern coach Carlo Ancelotti agreed with Vidal and said in his media conference that the referees needed video help.

Arturos card was not a card and then two goals for Cristiano were offside, said the Italian.

We are not happy about this. In a quarter-final you have to have a referee with more quality, I think. Its time to introduce videos for the referees.

His Real Madrid counterpart Zinedine Zidane did not want to discuss the refereeing but he claimed Bayerns second goal could have also been ruled offside.

Lewandowski appeared to be fractionally offside in the buildup to Sergio Ramoss own goal, causing panic in the area before the defender prodded the ball past Keylor Navas.

Read more | AFC Cup: Mohun Bagan may start with all-Indian 11 against Maldives Maziya

They have told me their second goal was also offside. It goes both ways, that is football, said Zidane.

More than the second yellow (for Vidal) or the offside goals, the six goals we scored over the two games mean we deserved to go through in the tie.

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The Technicals For CF Industries Holdings, Inc. (CF) Tell An Interesting Tale – NY Stock News

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The Technicals For CF Industries Holdings, Inc. (CF) Tell An Interesting Tale
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The technicals for CF Industries Holdings, Inc. (CF) have taken shape, and with them a comprehensive picture has emerged. This is the current state of play as presented by the current technical setup. The technical data for a stock offers a rich ...

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Political correctness continues to run amok – Washington Times

Posted: at 10:11 am

ANALYSIS/OPINION:

In todays academy, truth is an invention. Expecting people to show up on time is racist. Censorship is good. Silencing opposing viewpoints imperative. Violence to enforce safety is natural.

For the last 25 years, under the guise of political correctness, weve been watching the inexplicable flow into our culture. The idiotic demands of political correctness in the 1980s, ironically relying on the decency of the American people for their acquiescence, was just the prep course, an amuse bouche before the main course of creating social chaos and destruction.

It sounds dramatic, and it is, and its also the only way the left maintains power brainwashing people into believing that social norms must be destroyed in order to create a more perfect society. From the ashes would emerge the great collective phoenix.

Just ask the Soviet Union, Cambodia, Cuba and Venezuela how well that works out.

Last year, we watched political correctness on campus jump with abandon into its perfected state of fascism. Within a year, we moved from weeping students demanding safe spaces to direct, organized violence to stop speakers who do not pay allegiance to the lefts status quo.

Perhaps with the ascent of Donald Trump, it was the shock of realizing the American people werent Venezuelan and were not inclined to commit mass suicide.

Consider some recent revelations, the natural trajectory from the crowd a generation ago that was demanding manhole covers be called personhole covers, and making mailman, fireman, and policeman all verboten. We assented, and a thousand steps later:

Reporting about Pomona College: Black students condemn truth as an invention of white people, want conservatives expelled. News about Clemson University: Public universitys diversity training: Expecting people to show up on time is racist. A headline about the work of an ungraduated researcher at University of Wisconsin-Madison: Teachers should allow Ebonics because English grammar is too hard for minorities to learn.

This activism at the academy is not only classically fascist, it destroys the future for the young people awash in its conditioning. Imagine, after all: What business, what culture, could survive a generation that thinks expecting people to be on time is racist?

Attempting to enact Orwellian rules at college is just one pastime of students. Free Beacon comments on the direct and often violent efforts to stop nonliberal speakers from being heard:

With Notre Dame students feeling unsafe at the prospect of Vice President Mike Pence speaking at their commencement, the riots at Berkeley caused by the presence of professional troll Milo Yiannopoulos on campus, and the explosive protest in March against author Charles Murray at Middlebury College that resulted in the assault of a professor, the war on campuses against freedom of expression and hearing opposing views is pervasive and troubling.

To say the least.

Last week, the University of California at Davis Student Senate voted to remove the American flag from Student Senate meetings. If you want it to be visible, you have to file a petition in an effort to convince others.

Todd Starnes reported one UC Davis students support of the action on her Facebook post: Why do you feel that advocating for the U.S. flag that represents a history of genocide, slavery, and imperialism is more important than stuff that actually matters like I dont know, the violence against our LGBTQ Brown and Black students, rising tuition, resources for our students without homes, she fumed. What a waste of time.

The odds are quite high that the students at this public university are relying on a variety of federal, state and alumni loans to finance their rage against the machine. Perhaps some of the assistance should be reconsidered when a classic education is taking a backseat to social justice warrioring. On Monday, I appeared on Tucker Carlsons Fox News program discussing this after the student leaders canceled a planned appearance on the program. Apparently, their college bubble was threatened.

Yet, college was supposed to be the bubble destroyer. Leaving home and all familiar, thrown into a new, challenging world. You are to be prepared for a world bigger than you, and certainly different from you.

Instead, we are infantilizing students, appeasing and placating them, condemning them to a life uncertain. Who needs time management? The ability to work and live with people unlike yourself? Why not resort to violence because youre upset or angry or irritated?

It has been a perfect storm creating this disaster, one of which is the lowering of expectations of students in general because of the rot of political correctness. Our public schools have failed so miserably, universities now cant hold applicants to any sort of standard.

Consider the frighteningly absurd decision by Stanford, as The Wall Street Journal reported: Every year, Stanford asks its applicants an excellent question: What matters to you, and why? Ziad Ahmed of Princeton, N.J., summed up his answer in three words. His essay consisted of the hashtag #BlackLivesMatter repeated 100 times. He got in.

We can answer Stanfords question quite simply: What matters to us are college degrees that still mean something; graduates who are ready to contribute to society and are ready to pursue dreams in business, life and society. What matters to us is the future. What matters is us winning this existential fight for students and a nation being abandoned by the liberals running our universities.

Tammy Bruce, author and Fox News contributor, is a radio talk show host.

Presidents change and lawmakers come and go, but The Washington Times is always here, and FREE online. Please support our efforts.

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UCLA Conservative Professor May Be Fired From Job For Refusing to Cave In to Political Correctness – Heat Street

Posted: at 10:11 am

TheUniversity of California Los Angeles (UCLA) administration is allegedly trying to sack an outspoken conservative professor for his resistance to political correctness.

Keith Fink, a UCLA professor who teaches classes on entertainment law and free speech, fears the university could an upcoming professional review to helppush him out of the institution.

Fink has previouslycaused waves on campus by refusing to embrace trigger warnings and safe spaces, prompting the universityto block some students from taking his classes.

University policy dictates that every lecturer must undergo a periodic Excellence Review to judge their performance.

If a panel of senior faculty members decide the professor doesnt meet the excellence standards, they are forced to leave the position.

Fink told The Daily Wirethat such reviews are normally just a formality, but the university administration is throwing obstacles in his path.

According to the emails acquiredby the Wire,the officials have reprimanded Fink for incorrect admin in soliciting statements from students to support his teaching a charge Fink denies.

He also claims the department ignoring his nominees for students to contact and using a different list, purposefully skipping one which praised him particularly strongly. Only when he noticed that the document was missing, the department fixed the allegedly accidental mistake.

The student who wrote the letter toldthe site:No reasonable person would believe that my letter was accidentally omitted from the dossier, because presumably it flatly contradicts the departments narrative, the student said.

They asked me what my honest opinion was, and I spent hours articulating how Professor Fink is an excellent instructor and explaining the impact he has had on my life.It infuriates me to hear they attempted to (by accident or by malice) discard my opinion simply because it contradicts their mission.

TheUCLA administration also solicited a number of negative letters from students, which the professor believes are exaggerated.

One allegedly accuses him of using racial slurs without the context that he was teaching a class on the First Amendment and whether they were protected.

Fink told the Wire:The way the system is, this is the easiest way for them to get rid of me. This is the perfect storm.

Heat Street has contacted UCLA for a comment, but has yet to receive a response.

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‘Political correctness’ focus of talk Wednesday at Ripon College – Fond du Lac Reporter

Posted: at 10:11 am

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Jake Jacobs, a speaker, writer and historian, will present Political Correctness: Stifling Freedoms in Schools and Society.

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Ripon College 1:07 p.m. CT April 18, 2017

Jake Jacobs(Photo: Courtesy of Ripon College)

RIPON - Jake Jacobs, a speaker, writer and historian, will present Political Correctness: Stifling Freedoms in Schools and Society at Ripon College from 4:30 to 5:15 p.m. on Wednesday in Kresge Little Theatre, East Hall, on the campus. Free pizza and beverages will be provided.

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Jacobs teaches history at Lourdes Academy in Oshkosh. He is the president and founder of Liberty Proclamation Education and has degrees in American history and biblical and Judeo-Christian studies from Arizona State University, Ashland Theological Seminary and North-West University. He has spent more than 28 years in public and private high schools as well as at the college level, teaching his passion for our Constitutional Republic under God, all the while stressing historical correctness, in the face of politically correct intimidation by the academic establishment.

As a public high school teacher, he publicly defended Wisconsin Gov. Scott Walker on Fox & Friends. He is a popular speaker for Young Americans for Freedom, conservative radio, and Tea Party, civic and church events.

For more information about Ripon College, visit ripon.edu.

Read or Share this story: http://fondul.ac/2oSghLz

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'Political correctness' focus of talk Wednesday at Ripon College - Fond du Lac Reporter

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Gore: Freedom triumphs over stupid notions of eugenics – Danville Commercial News

Posted: at 10:10 am

Recent articles in the Commercial-News provided me with some education.

One article reminded me of history I had forgotten: that about 1849, following the Mexican/American War, large portions of the Southwest became U.S. property. Later, I wonder if this information had a connection to eugenics, defined in an editorial by George Will, Eugenics was a progressive cause.

Mr. Will defined eugenics as controlled breeding to improve the heritable traits of human beings; a really disgusting idea, but one that was discussed frequently from 1875 to 1925 and again in the 1994 book, The Bell Curve by Charles Murray. Will reported that Murray was not permitted to speak at Middlebury College because liberal students there failed to recognize that eugenics was originally an idea of progressives, not conservatives. Who knew?

Some of Wills quotes from those supporting eugenics are so outlandish, I will not mention them, but one involved former liberal President, Woodrow Wilson. Wilson, according to Will, had contrasted the sturdy stocks of the north of Europe (Germany, Norway, etc) with those of southern Europe (Spain, Italy) who had, neither skill nor energy nor any initiative of quick intelligence.

President Wilson must have known little about the damage that governments can inflict upon their citizens and/or had little belief in the benefits that individual freedom and a free market can deliver. He must have also forgotten that both Spain and Italy, at one time in their histories, were great and conquering world powers.

Spaniards, Italians, Mexicans, Germans and Americans, black, white and Hispanic, are not stupid people who need, somehow, to be improved; all of us are simply people, human beings, each born with the potential of genius. It is the impact of how people are educated, treated and given freedom to pursue happiness that impacts the skill, energy and initiative of quick intelligence, referred to by Wilson, not their so called inherent traits. Many examples prove this.

Most dramatically was the split that occurred in Germany after WWII. In the blink of an eye, West Germany became a smart, sturdy stock, and had a booming economy, while East Germany eventually collapsed under its own weight, economic development hindered by loss of freedom under Russian rule. Had East Germans suddenly lost their skill, energy and intelligence?

Before 1990, Spanish laws had been imposed to reduce unemployment, limiting workers to 11 total months of work annually. As a result, Spanish businesses needed many extra employees to provide coverage for unexpected overtime and vacations. These rules produced no noticeable benefit. Unemployment in Spain was about 18 percent in 1990 and is still 18 percent, highest in Europe. Why? Unneeded employees means higher prices for goods, less international trade and less capital and incentive for improvements; a result of governmental limitations, not lack of energy among the workers.

I wonder If the American Southwest had not been obtained from Mexico, Would Houston, Phoenix, and Los Angeles be the great metropolises of today or would they be average Mexican cities with many citizens desiring to live in the United States? What is it about that imaginary line that divides Americas wealth from Mexico if not Mexican law? In rural Mexico I observed an economy that seemed to progress into the 1950s, then stopped (1950s dcor, autos, farming, and construction). Yet, a meat casing plant in rural Mexico, similar to Teepak/Viscofan, is operated just as competently by Mexican workers as American workers operate Teepak/Viscofan in Danville.

Yes, America is blessed by many natural resources, but no more than Russia, a country with only one-seventh as large of an economy. Yet another example showing that freedom triumphs over stupid notions of eugenics.

Ron Gore is a Covington resident and former Commercial-News newsboy and scholarship recipient. He can be reached at rgore1942@spamarrest.com. (emails will require a conformation sending if returned to sender).

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Adolf Hitler learned eugenics from American sterilisation camps, says historian – talkRADIO (press release)

Posted: at 10:10 am

Adolf Hitler learned about eugenics from sterilisation clinics in America,according to a renowned academic.

Yale University historian Daniel Kevles, who has recently retired, made the astonishing claim in reference to a string of genetics laboratories which sprang up in America around the turn of the 20th century,according to the BBC.

Although Kevles believes Englishman Francis Galton, a cousin of Charles Darwin, was the founding father of eugenics in the mid-19th century, the idea was adopted inAmerica as a solution to the social problems caused by mass immigration and urban overpopulation after the country's civil war.

The historian said that "because America seemed to find itself 'degenerating'" due to problems such as povery, alcoholism and prostitution, support for eugenics crystallised in a series of research centres, and the movement "went through the roof"after a landmark legal case in 1927 ruled that sterilisation was valid under the US constitution.

During the 1930sa wide range of perceived ailments and disabilities - blindness, epilepsy and mental illness among them - were treated with sterilisation, and some states continued the practicefor years after the Nazis' crimes had emerged. In fact the state of Virginia continued to sterilise people until 1979.

Intotal it is estimated that up to 70,000 people were sterilised across the United States, in centres such as the Cold Spring Harbour laboratory, an hour away from New York, which is still active today and admits its role in propagating eugenics on its website.

"If you mention the word 'eugenics' many people associate it with the Nazis and the Holocaust," Kevles said. "But this is erroneous.

"In fact, Hitler learned from what the Americans had done."

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Adolf Hitler learned eugenics from American sterilisation camps, says historian - talkRADIO (press release)

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