Daily Archives: April 7, 2017

A growing number of women are swapping the therapists sofa for hallucinogenic medicine. But does science back up the benefits? And whats it really like to get high for therapeutic purposes? Health journalist Charlotte Haigh experiences the highly controversial world of psychedelic psychiatry first-hand to find out

Im sitting in the humid blackness of a wooden hall in the depths of the Peruvian Amazon. The only sound is the clicking of a shamans beads as he pours out shot glasses of a murky brown liquid. The substance is ayahuasca, a traditional hallucinogenic medicine made of up of two plants: chacruna, which contains a substance called DMT generating visions, and the ayahuasca vine itself, which allows DMT to work in the brain. Its a Monday night and it suddenly strikes me how far away I am away from my regular Monday evening routine scanning the latest news on my phone in my flat in the London suburbs after a long day meeting deadlines as a freelance health journalist.

I look around at the 20 other people in the room, mostly European professional men and women in their late twenties to mid-forties. Were all here on an organised retreat, to participate in four ayahuasca ceremonies in an attempt to sort out deep-rooted emotional or psychological problems, or simply work out our next steps in life. Were hoping this strange brew, used by Peruvian shamans for centuries, might just give us the answers were struggling to find at home. In fact, studies are now suggesting psychedelics may help a range of mental health conditions, which is why Im here.

The strongest evidence is currently for addiction, then depression and anxiety, followed by moderate evidence for obsessive compulsive disorder (OCD), says Professor David Nutt, a psychiatrist and neuropsychopharmacologist I speak to for advice, and who has pioneered the research. In a study we published in The Lancet, one dose of psilocybin, found in magic mushrooms, produced lasting changes in people with chronic depression who hadnt responded to medicines or to therapy. Half of the participants were still well after six months. Its not a magic bullet, but its very promising.

Psychedelics are considered relatively safe in comparison to alcohol, but experts strongly advise against trying them in a recreational or non-clinical setting, as you may have a disturbing experience. As psychedelics loosen your brains usual patterns, defences start to dissolve, says Dr Rucker, a psychiatrist who researches the effects of psychedelics. That can be hard, because its the things you dont want to deal with that you keep locked away. Thats why you need a safe, supportive environment and someone you trust like a therapist to help you work through difficult things. Anyone with a family history of mental-health conditions such as schizophrenia, and anyone taking drugs, including SSRI antidepressants, should avoid them completely.

As I gulp down the thick, sickly drink and lie down on my assigned mattress, I wonder what will come next. As a health journalist, Ive done my research and spoken to many people whove taken it. I know its considered safe, but Im nervous about what my subconscious mind might show me under the influence. Im not a natural risk-taker so its certainly a step outside my comfort zone, but it may help me work through some relationship issues Ive been struggling to process this past year. Thankfully, this is not like taking drugs in a nightclub. It feels like a safe environment and there are experienced assistants and shamans on hand to offer support. We are sitting in a large, circular wooden building and mattresses are arranged around the outside of the room. For a few days before, I follow the special cleansing diet no alcohol, sugar, caffeine, pork or fatty foods and as requested by the organisers, I have set an intention in my mind of what I want to gain from the journey.

After half an hour of drinking the liquid, a wave of nausea surges through me. The medicine is infamous for causing vomiting. I grab the plastic bowl next to the mattress but the feeling passes and then Im plunged into a vision, like a hyper-vivid dream. Im on a rain-whipped beach, trailed by three shivering, sad-eyed children. I recognise at once that theyre the babies I lost in successive miscarriages while trying for a longed-for child with my then-husband, who Im now in the process of divorcing. I cuddle them but theyre still cold, so I put them all into a sack and search for a sanctuary. When I open the sack again, theres just a pile of ashes. Im distraught. And then a huge sun bursts the clouds open and I see a woman in the sky, smiling and cradling the children. Im crying, but then Im overwhelmed with a sudden sense of peace.

Later, when I come to process my journey, as ayahuasca trips are termed, I know Ive finally reached a point Ive been struggling to get to for months: Ive accepted my losses. In my trip, I came to a forest, where I saw a vibrant woman with a group of people, laughing and watering plants. It was me. It seemed to suggest that I still have a role in society even if Im never a mother which is something Id been grappling with.

Following my four-hour trip, I feel newly calm and positive about my future; a sense that something deep has shifted. Six months on, that feeling hasnt left me. Your brain is like a snow globe capable of being shaken up. Psychedelics may help get you out of an entrenched perspective, Dr Rucker tells me later. Biologically, all psychedelics, including ayahuasca, psilocybin (magic mushrooms) and LSD, stimulate the 2a serotonin receptors, found most commonly in the pre-frontal cortex of the brain, the area that processes and coordinates complex information to help you think and get perspectives on different situations. This area also helps you define your sense of self and the world, so that can become distorted when something goes wrong here.

Brain scans show that in depression, the prefrontal cortex is overactive, as people become trapped by repetitive negative thinking. By triggering the type 2A serotonin receptor, the psychedelic encourages the brain to broaden its scope and come up with other ways of seeing things. Under the influence of a psychedelic, the overactive bit of the prefrontal cortex quietens down, and parts of the brain that werent talking to each other start communicating, adds Dr Rucker.

This cross wiring may be one of the reasons why synaesthesia where your senses get mixed up is a common experience with psychedelics (on my first ayahuasca journey, I associated yellow colours with an intense raspberry flavour).

But while the brains biological response to the drug is key, the trip itself also plays an important role. The more spiritual or personal the experience, the more likely people are to have long-term benefits, says Dr Rucker. Theres no guarantee youll get a big breakthrough and not everyone has powerful visions, but for some it can be profound. Sarah, a 32-year-old solicitor, spent two weeks in Peru at an ayahuasca retreat, drinking the medicine every other night to help her overcome grief following her sisters death. Id become scared of losing people I cared about and was avoiding relationships, she says. On my journey, I saw a coffin and the lid started to open. I was terrified, but when I looked inside I saw galaxies of moons and stars. Ive never been religious, however I had a new understanding that nothing is truly final, and that life can be beautiful again. Somehow, it moved me on.

Ayahuasca can be challenging, though. It made me look at things Id been avoiding in real life, says Susannah, 26, a social-media manager from London. I went to a retreat in the Netherlands because I was having relationship problems and wanted to work through them. Id never taken drugs in my life. A friend had found ayahuasca helpful with body image issues and I thought it might be what I needed. In one journey, I saw myself on a battlefield trying to help someone who was badly injured, but they bled to death. Afterwards, I realised the person who died represented my relationship Id been trying to fix it but the medicine showed me I couldnt. Although it was upsetting at the time, it gave me the confidence to leave. Dr Rucker believes millennials may be more willing to look to psychedelics for answers because theyre more educated about the risks and benefits. This generation has always been exposed to the internet and many different sources of information theyre more curious about the psychedelic experience and dont believe the demonisation of drugs. Magic mushrooms and ayahuasca are both natural substances and ayahuasca has been used in a sacred way for thousands of years, which might be part of its appeal.

In the UK, psychedelics are illegal, so its not possible to take them in a clinical setting. This may be a reason why retreats in Peru like the one I attended are soaring in popularity. Ayahuasca is taken in a group ceremony led by highly experienced shamans and assistants to keep an eye on everyone, so you feel safe, says Skie Hummingbird, a UK-based shaman who takes groups out to Peru (sungate.org.uk). But you need to choose the right place, as some centres are run by unscrupulous people who arent properly trained. Personal recommendation is the best way. And shes seen radical transformations. Some people undergo dramatic changes on a ten-day retreat, overcoming lifelong problems, she says. But its not for everyone: some people do report having highly distressing journeys.

Some of the latest research suggests ayahuasca could generate the birth of new brain cells, potentially treating neurodegenerative disorders like Alzheimers, as well as psychiatric illnesses, while LSD and psilocybin show promise in treating post-traumatic stress disorder (PTSD). However, Professor Nutt advises caution. We need more studies, and such studies are limited by the law. Psychedelics are currently schedule 1 substances, which means theyre considered dangerous, making further research almost impossible. Nevertheless, the growing wave of interest in psychedelic psychiatry (a recent public talk at University College London sold out in 20 minutes) may address that. As Professor Nutt observes, Its groundbreaking science. These substances could potentially change peoples lives, providing we can do more thorough testing.

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Tripping out: the highs and lows of psychedelic therapy - Marie Claire UK

At the end of a dark earthen trail in the Peruvian Amazon stands a round structure with a thatched roof that appears to glow from within.

In the Temple of the Way of Light, as it is known, indigenous healers called Onanya teach visitors about the therapeutic uses of ayahuasca, a hallucinogenic brew that's been used by locals for thousands of years.

Across the Atlantic, researchers in an ornate blue-tiled hospital in Barcelona, Spain are studying ayahuasca's physical effects on the brain.

The teams in those two disparate locations approach the study of the psychedelic drug very differently, but researchers at each one are coming to similar conclusions about the way ayahuasca affects the mind.

Among volunteers who take ayahuasca for studies, scientists have documented a rise in certain key traits that mirror those of experienced meditators. These changes include increases in openness, optimism, and a particularly powerful ability known as decentering.

Amanda Feilding, the founder and director of the UK-based nonprofit Beckley Foundation, collaborates with scientists around the world to understand how psychedelic drugs affect the brain.

Feilding describes decentering as "the ability to objectively observe one's thoughts and feelings without associating them with identity".

Decentering might sound esoteric, but it's one of the key aims of mindful meditation and is also a goal of successful depression treatments in some cases.

In volunteers who've taken ayahuasca as part of Beckley's research, decentering has been linked with higher scores on questionnaires designed to measure well-being and happiness and lower scores on measurements of depressive or anxious thoughts and symptoms of grief.

"It's interesting because even though our research out of Peru is based on surveys, while in Barcelona it's based on more traditional scientific research, our results out of both places are showing an increase in these traits," Feilding says.

"It seems patients are finally able to liberate themselves from the emotional pain they have long been suffering from. To calmly observe one's thoughts and feelings in an objective way in order to become less judgemental and more self-accepting."

Since the findings out of Peru are based on surveys, they can't prove that ayahuasca caused the reduction in symptoms of depression and grief - only that there's a connection between the two.

But in Spain, as part of a collaboration between Beckley and Sant Pau hospital, neurologist Jordi Riba is looking at the brain activity in depressed volunteers who are given ayahuasca.

His findings indicate that in addition to people simply reporting that they feel more decentered and less depressed after taking ayahuasca, there is a corresponding neurological change in their brain activity.

One small study of 17 depressed volunteers who took ayahuasca saw a decrease in activity in areas of the brain that tend to be overactive in conditions like depression and anxiety.

And a new study of regular ayahuasca users suggests a physical shrinking in these parts of the brain, though that work has not yet been published in a peer-reviewed journal.

These findings are bolstered by other research on the potential therapeutic effects of psychedelics. Studies out of New York University and Johns Hopkins suggest that the psychedelic drug psilocybin - the ingredient in magic mushrooms -elicits similar effects among depressed people.

"With the psilocybin, you get an appreciation - it's out of time - of well-being, of simply being alive and a witness to life and to everything and to the mystery itself," Clark Martin, a patient who participated in one of the Johns Hopkins trials, previously told Business Insider of his experience.

David Nutt, director of the neuropsychopharmacology unit at Imperial College London, has been working with Feilding, and says the brains of people with depression or addiction get locked into patterns of thinking driven by the brain's control centre.

"Psychedelics disrupt that process so people can escape," he says.

This article was originally published by Business Insider.

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Meditation and the psychedelic drug ayahuasca seem to change the brain in surprisingly similar ways - ScienceAlert