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Monthly Archives: March 2017
Nanotech Security Corp (NTS) Price Target Cut to C$1.75 – The Cerbat Gem
Posted: March 6, 2017 at 3:28 pm
Nanotech Security Corp (NTS) Price Target Cut to C$1.75 The Cerbat Gem Nanotech Security Corp logo Nanotech Security Corp (CVE:NTS) had its target price decreased by equities research analysts at Canaccord Genuity from C$2.00 to C$1.75 in a research note issued to investors on Thursday. The firm currently has a ... |
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Nanotech Security Corp (NTS) Price Target Cut to C$1.75 - The Cerbat Gem
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Ti-Nanotech Acquired by Defense Industry Veteran Kevin Ruelas … – Benzinga
Posted: at 3:28 pm
Defense industry veteran Kevin Ruelas and his team announce the acquisition of Ti-Nanotech, formerly known as Crista Chemical Company.
SAN DIEGO (PRWEB) March 02, 2017
Defense industry veteran Kevin Ruelas and his team announce the acquisition of Ti-Nanotech, formerly known as Crista Chemical Company. Ti-Nanotech will join Syndetix, Inc., under the umbrella of the newly formed Defense and Government Solutions (DGS).
"We're thrilled to bring Ti-Nanotech's advanced and patented technology to our customers in the defense and law enforcement sectors," stated DGS and Ti-Nanotech CEO Ruelas. "By bringing Ti-Nanotech together with Syndetix under DGS, we see opportunities for growth in sectors where material strength and reliability are paramount, including aerospace and commercial products such as batteries, medical devices and military hardware."
Ti-Nanotech began as Cristal Chemical Company in 1999, focused on finding a non-toxic replacement for cadmium plating. They sought to do this without compromising strength, adding weight or creating corrosion issues. The solution was titanium plating for end products, which has applications in a variety of sectors including defense, commercial, aerospace and automotive.
Since then, the company has earned a reputation as a thought-leader in titanium coating. Titanium can be stronger than steel while being much lighter with the highest strength to weight ratio of any metal. It is also non-toxic and one of the only metals able to be put inside humans. Ti-Nanotech's patented technology makes titanium coating possible for a wide variety of industries including armored shields, reinforced consumer products such as medical devices and the growing field of next-generation batteries.
Ti-Nanotech will join Syndetix Inc., a service-disabled, veteran-owned small business and technology developer for the defense and law enforcement industries, under the umbrella of the newly formed DGS. With established contacts and customers in the defense and law enforcement sectors, DGS will introduce Ti-Nanotech's technologies to new audiences. With the formation of DGS both companies will be able to expand by reaching new customers leveraging their technology and service offerings including the aerospace industry and medical device manufacturers.
About DGS Formed in 2016, Defense and Government Solutions (DGS) and its holdings serve clients in the defense, law enforcement and commercial sectors. Its main holdings include Ti-Nanotech, focused on titanium electromagnetic plating for end products, and Syndetix, a technology company focused on designing, engineering and building technologies for international and domestic security forces. DGS is a service-disabled, veteran-owned small business based in Las Cruces, N.M.
About Ti-Nanotech Since 1999, Ti-Nanotech has been in industry leader in titanium plating for end products. From the defense sector, to the aerospace industry and even the medical device field, Ti-Nanotech's titanium electromagnetic plating process can be applied to a variety of end products. Ti-Nanotech is a defense and government solutions company based in San Diego.
About Syndetix Since 1985, Syndetix, Inc. has been designing, engineering and building technologies that protect those who protect us. Founded as a technology spinoff from New Mexico State University's Physical Science Laboratory, Syndetix, Inc. provides high-caliber design and engineering services for the Department of Defense, Department of Justice and civilian markets to enable mission critical success.
For the original version on PRWeb visit: http://www.prweb.com/releases/2017/03/prweb14107155.htm
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Ti-Nanotech Acquired by Defense Industry Veteran Kevin Ruelas ... - Benzinga
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A New Cold War Has Begun and WW3 Is a Clear Possibility Now – Lombardi Letter
Posted: at 3:28 pm
Could Trumps Military Spending Surge Be the First Salvo of WW3?
Russian President Vladimir Putin welcomed Donald Trumps election. Yet World War 3 seems closer now. The Russians feared Hillary Clinton, who spoke aggressively about Russia. Yet, not two months into the Trump presidency, and conflict with Russia, or WW3, seems closer. It was under Hillary Clintons tenure as Secretary of State that the Maidan revolt took place in Ukraine.
That was the catalyst for a civil war between pro-West and pro-Russia Ukrainians. Putin toasted Trumps win last November. But, as Trump announced a massive increase in military spending, the Kremlin issued a statement that, while short on words, was deafeningly loud on content.
The Russian president said that relations between Moscow and Washington are at their lowest point since the Cold War. What has changed? Russia WW3 2017, China WW3, or WW3predictions in general are not just for catastrophists any longer. Trumps firstand most successful so faraddress to Congress made it clear he wants a much bigger military.
During the campaign, Trump did not hide his military ambitions. Yet, even as he advocated more spending on military equipment, his major military and geopolitical target was Islamic State or ISIS, rather than Russia. Trumps focus was going to be the Syrian war. The bigger military, moreover, was going to serve as a friendly reminder to China about its own military buildup.
But China is not the only power on Trumps agenda. There have been allegations that members of his cabinet have had meetings or contacts with Russian officials. Theres nothing especially incriminatory about that. But while the media harps on about what that Russian ambassador said to this Trump insider, it has ignored a crucial thing.
Trump and Putin have not met yet. Trump has done absolutely nothing that Putin might interpret as a win for Russia. If anything, the Trump administration has stayed on message where Ukraine is concerned. Trump has also threatened Iran, a close Russian ally in the fight against ISIS and the Syrian rebellion in general.
The one member of the Trump cabinet who may have had the closest ties to Putin was General Michael Flynn. He resigned a few weeks ago from the post of National Security Advisor. Flynn allegedly told Moscows ambassador to Washington that the Trump administration would cancel the additional sanctions leveled against Russia by the outgoing President Obama.
Flynn, according to critics, became vulnerable to possible blackmail from the Russians. Flynn thickened clouds of suspicions about Trumps relationship with Moscow. Regardless of the level of contact, what is clear is that the many deliberations about the budding Trump-Putin ties have died in the bud.
Putin is pursuing a Russia First policy; it was never going to mesh with America First properly. Indeed, the kind of spending that Trump has promised to lavish on the military deserves to be described as historic. The Cold War ended to help stop the military buildup that ended up crippling the Soviet Unions finances.
It also helped reduce fears of another war, a nuclear war. And what is WW3 if not a nuclear war? The U.S. military budget under Trump will inflate by $54.0 billion. And thats just the first taste of what Trump has in mind. That amount will pay for new attack aircraft and for the production of other weapons to bolster the quality of the U.S. defense systems.
Its almost as if World War 3 is inevitable. In effect, the Pentagon will get almost 10% more than it did in 2016. In turn, other federal agencies will see a reduction in funding. These other pure Cold War policiesare those which many Americans thought they would never see again. Trump complained that the U.S. has not won a war in ages.
Both the boost in military spending and the logic that has prompted it are unusual. The U.S. is not involved in any major military conflict now. Its true that Special Forces are on the ground in Iraq and the U.S. Air Force has bombed ISIS targets in Iraq and Syria. But neither one of these goals or theaters of war requires special stealth aircraft or new weapon systems.
Trumps vision is wider and he wants to cast a shadow over Chinaexpectedand Russiaunexpected. Trump mentioned ships as one of the reasons to increase military spending. He also wants more planes. The addition of a single ship or watercraft would add nothing in the fight against ISIS or terrorism in general.
It would, however, help drive a China WW3or Putin WW3 scenario. The ships and planes make nothing but sense against the lens of the Strait of Hormuz, which separates the Arabian Peninsula the coast of Iran. The Pentagon clearly wants a bigger presence to control key international waterways such as the Strait of Hormuz and the South China Sea.
More ships and planes would also help keep a closer watch over the Arctic and northern seas, where Russia has been intensifying its own patrols. Apart from Iran, this military buildup, then, provokes Russia as well as China. America already has the most powerful fighting force in the world, by several orders of magnitude.
America already spends more on defense than any other country:
(Source: Trends in World Military Expenditure, 2015, Stockholm International Peace Research Institute, April 2016.)
Not all in the military share Trumps bellicose ambitions. A group of over 100 retired U.S. generals and admirals have urged Congress to fully fund American diplomacy, rather than weapons. They see more strength in a combination of diplomacy and defense as the best way to keep America safe. Trump thinks adding 74 ships and 100 jets is the best way.
But, diplomacy must take a backseat now. Not only does Trump want to increase spending on military hardware, he wants to increase the army to 540,000 active-duty soldiers. Thats a 15% increase, given there are currently 480,000 active-duty soldiers. And thats just the Army. Trump also wants more Marines; 50% more, from 23 to 36 battalions.
The President made no specific reference about the nature of the threat that requires this massive increase in military spending. But just a day later, like a thunderbolt from Thor, the Swedes delivered a hint. Sweden wants to bring back conscription. Sweden happens to share the Baltic waterways with Russia.
The Baltic States, including Latvia, Estonia, andPoland, are among the most concerned about Russia. They happen to be in NATO. They are asking the U.S. for more defensive artillery and Patriot missiles to deploy along the borders with Russia. The Baltic is one of the regions of the world where World War 3 could start.
The other scenario comes from trade. Trump would like to find how the World Trade Organization (WTO) can impose sanctions and reprisals against countries accused of damaging Americas trade interests. Thus Trumps trade policy matches his military ambitions. Just to clear any doubts, Trump supports NATO. Now, he wants the WTO to support it as well.
Trump has ordered the Pentagon to develop a plan to demolish and destroy ISIS. The New Security Advisor, General Herbert McMaster has advised Trump to use the term radical Islamic terrorism sparingly. McMaster is more diplomatic than his predecessor Flynn, but the Middle East, as ever, remains a major trigger point for the next global conflict.
Its not so much ISIS but Iran thats the problem. Trump has not spoken much about the nuclear deal that Obama secured in 2015. But, if the new president were to repeal it, it would necessarily require a military strike against Irans well-protected facilities. The problem is that the deal ensured that Irans nuclear program remains civilianonly.
Without the deal, there are no internationally binding agreements holding Irans enrichment plansor threatsback. But, attacking the facilities would not be easy. Even stealth F-35 or F-22 fighter jets would suffer losses. Iran has Russias S-300 defense system, which renders the nuclear facilities virtually impenetrable.
Russia has a stake in this as well. Russia and Iran have been the main powers against ISIS and other Islamiststhe very kind Trump wants to eliminate. Attacking Iran would put Moscow and Washington in direct opposition. Not since the Cuban missile crisis would relations take such a turn for the worst.
Trump and Putin would never authorize the use of nuclear warheads in a conflict. But, the first strike option exists and could be unleashed, given the imminent threat of any kind of catastrophic attack. Neither Kennedy nor Khrushchev, both milder than Trump and Putin, were going to push the nuclear button. But the Cuban missile crisis did almost get there.
Nobody wants to test those odds again. Deterrence is not an exact science. There is also an art, which thankfully, nobody has had the misfortune of practicing yet. One party will always strike first. Its up to the retaliating party to decide what direction the conflict, in this case WW3, might take.
Albert Einstein famously observed that he didnt know how World War 3 would be fought, except that World War 4 would be fought with sticks and stones. But, there is a nuclear threshold. Both Trump and Putin can choose a scalable nuclear conflict rather than a full-out one. Miscalculation could trigger unimaginable consequences.
The general view is that both the U.S. and Russia would use nuclear warheads only after defeat would be assured in the conventional scenario. Thus, the idea that WW3 might be won using conventional weapons alone still exists. Its up to the losing party to decide if they want to bring down the world with them.
That said, this, theoretically, justifies Trumps military buildup. The logic being that an overwhelming conventional attack would defeat the enemy before they would have a chance to bring nuclear weapons into the calculus. Putin did not appreciate Trumps military spending plans because it forces Russia to respond in kind.
But Russias economy is in a slow recovery mode at best. It cant afford an arms race. Trump, perhaps, wants to take advantage of that weakness with a massive spending surge now to overwhelm any potential enemy from even considering challenging the United States. Its a gamble.
Its also a guarantee that for the next few years, defense contractors in Washington will do brisk business. Russia will have to increase its arsenal buildup as will China, perpetuating the cycle.
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A New Cold War Has Begun and WW3 Is a Clear Possibility Now - Lombardi Letter
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WATCH: A Public Policy Expert Explains How to Safely Deregulate LSD and Other Psychedelics – AlterNet
Posted: at 3:28 pm
AlterNet | WATCH: A Public Policy Expert Explains How to Safely Deregulate LSD and Other Psychedelics AlterNet Timothy Leary he's not, but he is open to loosening up on psychedelics. Although he doesn't mention it in the short segment below, Kleiman is undoubtedly aware that psychedelics are not addictive and have a virtually non-existent fatal overdose ... |
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Hacking the Human Body with the CEO of Nootrobox – Paste Magazine
Posted: at 3:27 pm
Computers have been the innovation platform of the last decade. The human body will be the innovation platform of the next decade.
Those were the words Geoff Woo, CEO & co-founder of Nootrobox, who recently spoke at The Economist EventsInnovation Summit 2017. Nootrobox is a San Francisco-based nootropics company funded by Andreessen Horowitz, Yahoo CEO Marissa Mayer and Zynga CEO Mark Pincus, among others. The company is best known for GO CUBES, its chewable coffee nootropic (a compound you take to enhance cognition).
Woos area of expertise is the rapidly growing trend of biohackingtreating the body as hardware which can be improved through constant tweaking. Think everything from fasting to smart drugs, to implanting glucose monitors under your skin, to microdosing LSD and youll see why the human body is the next platform for innovation.
Basically, what started as a trend among techies in Silicon Valley is becoming more mainstream, with people drinking bulletproof coffee and taking nootropics to try to get ahead at work, at school, in athletics, in gaming, etc And Woo is part of a new generation of entrepreneurs who want to hack the brain and the bodyimproving everyday performance through nutritional supplements called nootropics.
Better Brains, Better Society
Nootropics are a broad classification of cognition-enhancing compounds which have shown to produce minimal side effects and seem suitable for long-term use. They are designed to heighten productivity, memory, mental function and overall physical energy. These compounds include those occurring in nature or ones already produced by the human body (such as neurotransmitters), and their synthetic analogs. We already regularly consume some of these chemicals: B vitamins, caffeine, and L-theanine, in our daily diets.
To better understand how this under 30 CEO is changing the face of cognition-enhancing compounds, Paste interviewed Woo about Nootrobox, his business philosophy and why he thinks millennials have an edge when it comes to start-ups.
Paste: Why did you start Nootrobox?
Geoff Woo: As a competitive person by nature, Ive always had the drive to tap deeper into my full cognitive and physical potential. So a few years ago, I dove into the world of biohacking and nootropics, and I really absorbed the science and theories behind nootropics and also the practical necessities like safety and quality control processes to enhance oneself safely. I had access to some of the top researchers and academics in the space (some who are now my colleagues and friends), and I thought that what I had learned might be valuable to other people. Thats when I decided to launch Nootrobox as a service for high-quality, science-validated nootropics.
Paste: How did you get the funds to start the company?
Woo: At the very beginning, I started running the company off my credit card and savings. We were very scrappy and didnt pay ourselves anything besides rent money. That scrappiness allowed us to be cash-flow positive from Day 1.
As the business started scaling, we realized that Nootrobox could really be special. We then invited some great friends and mentors to chip in to give us a working capital base. It snowballed from there. Now we have a great group of investors from VCs like Andreessen Horowitz to legendary founders and operators like Marissa Mayer.
Paste: What is the best part about running your company?
Woo: Our time is the most valuable asset we have, and I get to spend it in the trenches with some of the smartest, most driven people I know in the world. Its a real luxury to choose the team I get to work with!
Paste: Do you think millennial CEOs have an edge?
Woo: I think any CEO with the energy and fearlessness to work on what might sound like a crazy idea has an edge. Often times, these CEOs are millennials because theyre younger, fresher, and have less to lose.
Paste: Why do you think millennials are more likely to take risks and follow their passions?
Woo: They have less to lose. Its very scary to float your life savings on a crazy idea when you have a family and mortgage. The bar to pull the trigger to go is now that much higher, and often times the best ideas are what seem like the riskiest at Day 0.
Paste: How do you achieve work/life balance as the CEO of a high-growth startup?
Woo: I dont see a tradeoff between work and life. If theres a tradeoff, then youre doing it wrong as a CEO. Theres just one life. If I didnt thrive off what Im working on, Im doing my job as CEO wrong. I have the luxury to focus on a space that excites me intellectually. My style is to go all-in when Im in San Francisco, and then when I have a week or two to take a breather, Ill travel and try to totally unplug.
Paste: Why do you love what youre doing? Whats next?
Woo: Unlocking human potential is such an awesome opportunity. Theres so much blue sky to work in. I feel like were at the very start of the biohacking revolution just like how in the 70s and 80s was the start of the computer revolution. We get to make the future!
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Hacking the Human Body with the CEO of Nootrobox - Paste Magazine
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TMS to host fashion showcase – Troy Daily News
Posted: at 3:23 pm
TROY Troy Main Street will treat its Style Showcase Fashion Show guests to an evening of 2017 spring fashions from downtown Troy boutiques and dcor shops.
The event, being held on Friday, March 31, at the Troy-Hayner Cultural Center, features home dcor displays from 6-8 p.m. and a runway fashion show from 7-9 p.m. Downtown restaurants and venues are offering discounts for dinner the night of the show (with ticket), and ReU Juicery and Olive Oasis will be sampling healthy, fresh spring flavors at the event.
This is the second year for this event in downtown Troy. We are bringing most of our boutiques and home dcor merchants together, along with our hair salons, for a complete evening of styles and inspiration, said Shelly Calvert, marketing and events coordinator for Troy Main Street. We will be talking about how to create fresh spring looks that are uniquely you, including advice from event sponsor Christy Shell of Zeal Coaching.
Our guests can expect a variety of boutique clothing fashions and home dcor styles that will fit any age and style preference, Calvert added. Thats the fun of it everyone will be in one location, so people will get a sneak peek of whats for sale in our downtown stores. The hair salons will style the models hair, including up-dos, for spring looks, prom and wedding preview.
Tickets, which are $10 each, are required for the runway fashion show and restaurant discounts. Ticket holders will receive a swag bag full of coupons. No ticket is necessary to view the home dcor tables at the Troy-Hayner.
Tickets are limited to the first 130 guests, and go on sale March 10 at participating downtown Troy stores. A portion of the proceeds from each ticket will benefit Reading For Change.
Troy Main Street is a non-profit downtown organization whose mission is to Strengthen the heart of our community.
For more information about the Troy Main Street Style Showcase Fashion Show, go to troymainstreet.org, or call the office at (937) 339-5455.
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How ‘brain wearables’ can address 21st century needs – IoT Tech News
Posted: at 3:22 pm
The human brain is the mostcomplex system in the known universe. It is imbued with enormous potential that we have yet to fully understand or to harness. But were making progress, for many good reasons.
By studying how the human brain functions and how it responds to stimuli, we can potentially train our minds for optimal performance and, perhaps, overcome physical disabilities or detect neurological abnormalities for treatment. We stand now on the cusp of what has been called The Fourth Industrial Revolution, a revolution that is growing out of the integration of the physical, digital and biological realms. The ability to directly connect electronic devices to the human organism in order to affect physical objects around us has the potential to drive change forward at an exponentially increasing pace. Our understanding of our limitations will be shattered, and new vistas will open up, as we explore the possibilities that arise when we bring minds, machines, and the material world together.
Put simply, we stand to reap enormous benefits if we can enlighten ourselves as to why and how we think and feel - to improve how we interact with and experience the world around us.
Today, innumerable such efforts proceed in specialised laboratories around the world, with a rather limited number of research subjects. But everyones brain is unique and changing in unique ways. The term neuroplasticity means that our brains change shape and function based on personal biological factors as well as our individual experiences in life. So were likely to gain commensurately greater insights from a broader participation in such studies.
And thats where brain wearables come into the picture.
A market for brain wearables has promised to put neurotechnology into the hands of ordinary people. This is important because of the uniqueness of every brain; the greater the sample, the more robust the insights it yields.
Today these devices fall into two main categories. One uses electroencephalograms (EEGs) essentially, surface brain wave activity in a non-invasive, read-only mode, which can provide data on the wearers mental and emotional state. The other basic approach relies on transcranial direct current stimulation (TDCS), which sends electrical signals to the brain for neuro-priming, which is intended to promote hyper-learning.
I work in the EEG-related field of brain wearables, which offer a means to further our understanding of the human brain in a useful form factor and at a reasonable price point.
We are using brain wearables to conduct longitudinal studies over time in more than 120 countries to discern how different stimuli and situations affect different brains, helping us understand, for instance, how different people react to handling stress or how we can assist them in achieving optimal performance.
In practical terms, understanding and encouraging high performance is one focus of our work, which would have obvious benefits for athletes, soldiers, professionals, artists nearly everyone, really. And the broadest possible application would be to gain a better understanding of how various stimuli and our own, often very individual responses affect our thoughts and feelings. The end result could be to inform an improved self-awareness and a better understanding of ourselves to mitigate irrational or unproductive behaviour.
Ultimately, those of us in the brain wearables field would like to make progress on the early detection of neurological issues and overall brain health.
One in three people, of the more than seven billion on Earth, are affected by brain-related illnesses, including depression, anxiety, dementia, autism, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), stroke or trauma. Apart from widespread human suffering, these disorders are estimated to cost the global economy some $2 trillion per year. In the U.S., specifically, an aging population has the potential for extended lives, for which quality-of-life will require healthy brains.
Brain health is also considered a key factor in many other bioinformatics advances. I think of it as a quintessential 21st century issue.
Though Im positively buoyant about the known and potential benefits of brain wearables, it is also our duty to be vigilant about the potential risks.
Data privacy and security are perennial concerns for everyone. These concerns are heightened when personal health-related matters are at stake. The Health Insurance Portability and Accountability Act of 1996 (HIPAA) provides legal protections and it is up to technologists to ensure that data privacy and security protections are state of the art.
Currently we are careful to apply significant effort and care to user consent issues for participation in studies we conduct. The critical issue, in my view, is preserving individual choice and the personal integrity of every individual.
I have few real concerns at this stage, because wearables are just that; you can put them on or take them off and anonymising data in studies is standard practice. But if brain wearables or related technologies were to become embedded in the human body, theres an obvious risk of abuse. Today, arguably, our thoughts and feelings are our own, but we know that chemical reactions govern these and thus they could be manipulated, leading to a loss of individuality.
Our approach is the opposite of a dystopian use of brain monitoring technology. Our philosophy is to democratize technology and make tools such as brain wearables more affordable, easier to use. Our technology platform is based on open access software (e.g., extensible APIs), aimed at both broad uptake (if the market finds them useful), and the broadest possible base of innovation to benefit all. We want to avoid creating another aspect of a digital divide, with brain wearables available only to a few who can afford them. We believe this approach is in step with societys shared values.
We work with partners across many domains and more than 120 countries, an open acknowledgement that we dont have all the answers. The direction that brain wearables take is not up to us as pioneers in the field. Its an open conversation. We simply want to position the technology and raise awareness for the greatest breadth and depth of potential contributions to the field. The more participants in brain wearable trials the more we learn about the behavior of the human brain and ways in which its health and optimal use can be encouraged.
Widespread adoption is the crux of our success. A broad and diverse dialogue on the issues of brain health and technology will enable the enhancement of healthy brains and detect signs of cognitive decline and disorders.
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How 'brain wearables' can address 21st century needs - IoT Tech News
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Vertex, Concert orchestrate $250M phase 2 CF drug deal – FierceBiotech
Posted: at 3:20 pm
Vertex could pay out as much as $250 million to gain full access to Concert Pharmaceuticals midstage cystic fibrosis (CF) candidate CTP-656, a tweaked version of its own Kalydeco, as it eyes combo uses that target the underlying causes of the fataldisease while taking over a potential competitor product.
The deal sees Vertex, which is looking to build up its marketed CF franchise, pay $160 million in cash with $90 million in biobucks also lined up for the future.
Thepharma gets CTP-656 for its moneyan investigational cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that the company hopes it can use as part of a once-daily combo of CFTR modulators that treat the underlying cause of CF.
This will dovetail with its CF meds: Kalydeco (ivacaftor) and more recently its combo therapy Orkambi (lumacaftor/ivacaftor).
Kalydeco is suitable for CF patients with the Gly551Asp mutation in the CFTR generepresenting just 4% to 5% of the total patient populationbut adding lumacaftor means that it can be prescribed for about 45% of patients. The second ingredient targets those carrying two copies of the much more common F508del mutation.
CTP-656 was in fact developed by Concert through the use of its deuterium chemistry to modify ivacaftor as it looked to make a better version of the drug. The big idea at Concert is taking approved or previously studied drugs and reformulating them with deuterium to boost their safety, tolerability and efficacy, creating new, and patentable, products in the process.
Back in 2015, the biotech posted data showing its treatment lasted longer than Vertex med in a small, early-stage trial. Clearly, Vertex wants to get its hands fully on this boosted version of its drug.
With Vertexs clinical and commercial expertise in CF, this agreement provides the optimal pathway to rapidly advance the development of CTP-656 for the benefit of cystic fibrosis patients, said Roger Tung, president and CEO of Concert Pharmaceuticals.
The financial strength provided to Concert by this agreement will allow us to advance [autoimmune med] CTP-543 into pivotal testing and broaden our proprietary development pipeline.
Concert is currently conducting a phase 2 study of CTP-656 in people with CF who have gating mutations. As part of the agreement, Vertex gains all rights to Concerts other CF research and preclinical programs.
Analysts at Leerink said they saw the deal as a positive for Vertex, saying in a note: "First, most obviously it removes a potential competitor, and, more importantly, a potential combination partner for other entrants who may possess a CFTR corrector. It signals Vertex's willingness to enhance and improve its existing franchise and portfolio in CF, rather than fret over "not-invented-here" considerations.
"Second, it offers a potentially improved profile for futuremulti-drug CF combinations. Third, it can extend the duration of Vertex's CF combinations even longer, given likely composition-of-matter exclusivity for Kalydeco of 2027 in the U.S. and 2025 in Europe, compared to 2032-plusin the U.S. and Europe for CTP-656.
"CTP-656 was one of numerous CF competitors in early clinical trials that have been advanced in parallel with Vertexs race to concoct a triple-therapy regimen for the majority of CF patients, and todays news signals, in our view, the willingness of Vertex to defend its dominant and valuable position in the market category."
Concert rocketedup more than 77%on the news while Vertex edged down 0.5%.
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Vertex, Concert orchestrate $250M phase 2 CF drug deal - FierceBiotech
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Revenue Approximations Analysis: New York Community Bancorp, Inc. (NYCB), CF Industries Holdings, Inc. (CF) – StockNewsJournal
Posted: at 3:20 pm
Revenue Approximations Analysis: New York Community Bancorp, Inc. (NYCB), CF Industries Holdings, Inc. (CF) StockNewsJournal CF Industries Holdings, Inc. (NYSE:CF), maintained return on investment for the last twelve months at -1.41, higher than what Reuters data shows regarding industry's average. The average of this ratio is 2.86 for the industry and sector's best figure ... |
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Mr. Brewster Raises $33500 for CF Research – HamletHub
Posted: at 3:20 pm
The Mr. Brewster Pageant was held last Friday and it was a tremendous success. The event is host by the S.A.L.T.Y Hands Club whose mission is toraise money and awareness for Cystic Fibrosis research. S.A.L.T.Y stands for Save A Life of Todays Youth. Individuals with CF also often exhibit a salty condition on their skin. For more information about Cystic Fibrosis or help support the efforts to find a cure please visit the Cystic Fibrosis Foundation webpage:https://www.cff.org.
For the Mr. Brewster title, contestant collect donations for the Cystic Fibrosis Foundation. They earn points for the money they collect. The contestants also receive points from the pageant event. The pageant includes several different activities to test the talents and the ability of contestants to think on their feet. Faculty judges included:, Peter Goumas, Michael Castaldo, Terry Schumacher, and Nicole Vitale Sweeney. The MC for the event was Matt Cunningham. Donna Lieval is the adviser of S.A.L.T.Y Hands Club and Mrs. Ann Marie Chalmers spearheads the activities for the Mr. Brewster event.
Brendan Feehan was crowned Mr. Brewster this year, but everyone involved did a wonderful job with the efforts. The other candidates that participated in the pageant event wereJack Guida, Sean Nevin, Connor Dignan, Sean Kelly, Nathan Beal, Tim Catalano, Ryan Wynne, Austin Kaelin, Ryan Hecht, Chris Zavras, Anthony Aiello and Spence Bera. Other individuals also collected money towards the effort but did not compete in the pageant. $33,500 represents an amazing effort from our group of students and will provide significant assistance toward CF Research.
BHS student Amber Krisch wrote a piece for the Hamlet Hub highlighting the the event. The article can be foundhere.
A complete video of the Mr. Brewster Pageant can be found here.
Hereis a video highlighting Brian McPartland and his activities at Duke University. Brian has CF and graduated from BHS and 2011.
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