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Monthly Archives: March 2017
Research gaps persist in psoriasis, psoriatic arthritis | Dermatology … – ModernMedicine
Posted: March 7, 2017 at 9:51 pm
Orlando The advent of increasingly effective and still costly biologic drugs for psoriasis and psoriatic arthritis (PsA) has highlighted the fact that dermatologists do not know which patients would benefit most from preventative measures.
A key unanswered question in psoriasis is whether physicians can predict and therefore prevent progression to PsA, said Mark Lebwohl, M.D. He is Sol and Clara Kest Professor and Chairman, Department of Dermatology, Icahn School of Medicine at Mount Sinai.
Before biologics, "The drugs that we had helped the pain of arthritis but were not dramatically effective at preventing joint destruction. Methotrexate is a classic example patients still benefit from it today, but the joints continue to deteriorate as evidenced by x-rays."
Tumor necrosis factor (TNF) alpha inhibitors were the first drug class allowed to claim that they prevent radiographic progression of PsA. "Etanercept was the first, followed by infliximab and adalimumab. Then came golimumab and certolizumab. These 5 drugs are dramatically effective for psoriatic arthritis they don't just get rid of the pain, but they also prevent x-ray progression."
More recently, the interleukin (IL) 17 blockers secukinumab and ixekizumab have shown similar abilities. "We have quite a few tools now to prevent joint damage. If we knew in advance which patients with psoriasis were going to develop psoriatic arthritis, it would help us help our patients. We could put them on those drugs early to prevent joint damage."
Among patients with psoriasis and PsA, he said, 72% present with psoriasis first. MRIs can show bone marrow edema (a sign of impending joint damage), "But we need better tests to predict which patients will get psoriatic arthritis." To that end, said Dr. Lebwohl, several companies are investigating genetic markers, while physicians continue to explore use of imaging modalities. "A genetic or serologic marker would be most helpful."
Similarly, researchers are attempting to predict which patients will develop other comorbidities such as cardiovascular disease. "When the biologics came out, patients were put into registries. And we've been finding, particularly with the TNF blockers, that there's a dramatic reduction in heart attacks in people who take these drugs."
A third knowledge gap, Dr. Lebwohl said, is which patients will respond to which treatments. "The new treatments that are coming out are dramatically effective in almost everybody. The problem is, they all cost a fortune." Knowing which patients would likely respond best and which ones would do just as well with cheaper treatments will help dermatologists and their patients immensely, he said.
Disclosures: Dr. Lebwohl has been a clinical investigator for most manufacturers of drugs for psoriasis and psoriatic arthritis. All payments from these companies go not to him but to Mount Sinai.
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DalCor’s Phase 3 Cardiovascular Trial, dal-GenE, Exceeds Targeted Enrollment Schedule – Yahoo Finance
Posted: at 9:49 pm
-- Dalcetrapib Studied in Genetically Distinct Patients with Acute Coronary Syndrome --
LONDON and MONTREAL, March 7, 2017 /PRNewswire/ --DalCor Pharmaceuticals today announced it is ahead of the enrollment schedule with the randomization of over 1,000 patients of the expected 5,000 patients planned for the Phase 3 "dal-GenE" clinical trial, a cardiovascular outcomes study of dalcetrapib in patients with acute coronary syndrome (ACS) and the AA genotype in the ADCY9 gene. Patients have been recruited at 642 hospitals in 30 countries, including the U.S., and on six continents.
The worldwide clinical trial is led by the Montreal Health Innovations Coordinating Center (MHICC), the Lead Academic Research Organization (ARO) and Medpace a leading Clinical Research Organization (CRO).
Approximately 1 in 5 of the general population harbor the AA genotype.
Quotes
Jean-Claude Tardif, C.M., M.D., director of the Research Center at the Montreal Heart Institute and professor of medicine at the Universit de Montral, and Principal Investigator for dal-GenE said, "We are pleased and gratified that recruitment goals are ahead of schedule. This is a testament to the need for precision medicine in this critically important sector of medicine; the DalCor approach is the first for cardiovascular medicine. Furthermore, it clearly shows the interest in the study and the necessity for a new therapeutic alternative for patients."
Marc Pfeffer, Dzau Professor of Medicine, Harvard Medical School, Senior Physician, Brigham and Women's Hospital, Consultant to the dal-GenE executive committeeand chair of the prior dal-Outcomes Safety Committee, said, "This impressive recruitment despite requiring a specific genotypereflects well on bothDalCor's experiencedinternational leadership team as well as the motivation of sites and their patients to be part of this major trial addressing a genetically targeted "precision medicine" approach. When completed, dal-GenE will be the first major test of pharmacogenetically profiling patients to improve prognosis following a recent myocardial infarction."
Donald Black, M.D., chief medical officer of DalCor, said, "This significant milestone is the result of the efforts of multiple parties collaborating around the world. Our clinical team, in partnership with a strong network of investigators and other groups, such as ANMCO in Italy, GLCC in New Zealand and ECLA in Argentina and Chile, have been able to work together and significantly improve the study's recruitment rate. It is the hard work of the dedicated team that has enabled the surprisingly quick physician response that has enabled DalCor to reach this important milestone in the short time since initiation.
We believe this compound has a unique profile and possesses a unique combination of safety and efficacy attributes for targeted patients which has the potential to greatly improve outcomes for patients worldwide.
There is much ahead, but DalCor is committed to completing this high-quality trial to obtain a reliable answer to this important question. For now, we look forward to continuing our clinical work in the dal-GenE trial, where we expect to demonstrate a significant reduction in heart attacks, strokes and cardiovascular deaths with the addition of dalcetrapib to the standard of care including statins in patients with ACS and the appropriate genetic profile."
About DalcetrapibDalcetrapib is the first precision medicine in the cardiovascular space to have reached full-scale development with this Phase III clinical study. Over 17,000 patients have participated in dalcetrapib clinical trials to date.
In 2012, investigators at the Montreal Heart Institute led by Professors Jean-Claude Tardif and Marie-Pierre Dub found a significant association between the effects of dalcetrapib in altering CV events and the polymorphism at the rs1967309 location in the adenylate cyclase type 9 (ADCY9) gene. Patients with the AA genotype had a 39% reduction in CV events when treated with dalcetrapib compared to placebo, while GG patients had a 27% increase and AG patients had a neutral effect. This analysis was conducted in 5749 patients. A prospective analysis of the dal-Plaque 2 study data has also demonstrated reduced atherosclerosis in the AA population when treated with dalcetrapib, but an increase in atherosclerosis in the GG population.
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About the dal-GenE StudyThe double-blind, randomized, placebo-controlled, multicenter Phase 3 clinical trial will enroll 5,000 patients recently hospitalized with ACS and who express the AA genotype at variant rs1967309 in the ADCY9 gene, determined by an investigational companion diagnostic test developed by Roche Molecular Systems (RMS).
The primary endpoint of the study is the time to first occurrence of any component of the composite of cardiovascular death, myocardial infarction (heart attack) and stroke. The trial will be conducted at 880 sites in 33 countries.
About DalCor PharmaceuticalsDalCor is developing precision treatments by genetically targeting patients that will derive clinical benefits. By integrating clinical and genetic insights, DalCor intends to deliver superior clinical cardiovascular outcomes. The company's first development program, dalcetrapib, is intended to reduce cardiovascular events in a specific genetic subset of patients.
DalCor secured a worldwide exclusive license for dalcetrapib together with rights to the genetic marker for use with dalcetrapib and is sponsoring the dal-GenE study, which is planned to include 5,000 patients to prospectively confirm the results of the pharmacogenomic analysis in the dal-Outcomes study in a patient population with the AA genotype at the rs1967309 location in the ADCY9 gene.
DalCor Pharmaceuticals has offices in Montreal, San Mateo, Calif., Zug, Switzerland and Stockport, U.K. For more information, visit http://www.dalcorpharma.com.
About the Montreal Heart InstituteFounded in 1954 by Dr. Paul David, the Montreal Heart Institute constantly aims for the highest standards of excellence in the cardiovascular field through its leadership in clinical and basic research, ultra-specialized care, professional training and prevention. It is part of the broad network of health excellence made up of Universit de Montral and its affiliated institutions. The Montreal Heart Institute ranks as the No. 1 research hospital in Canada for research intensity and research funds per researcher, according to Research Infosource. For more information, please visit http://www.icm-mhi.org.
DalCor Contacts:
CorporateDalCor PharmaceuticalsDonald M. Black, MD (609) 613-6637 dblack@dalcorpharma.com
MediaRusso PartnersAlexander Fudukidis (646) 942-5632 alex.fudukidis@russopartnersllc.com
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/dalcors-phase-3-cardiovascular-trial-dal-gene-exceeds-targeted-enrollment-schedule-300418898.html
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DalCor's Phase 3 Cardiovascular Trial, dal-GenE, Exceeds Targeted Enrollment Schedule - Yahoo Finance
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New genetic research provides hope for families with rare diseases – the Irish News
Posted: at 9:49 pm
the Irish News | New genetic research provides hope for families with rare diseases the Irish News The centre, spearheaded by consultant in genetic medicine Dr Shane McKee, have been involved in the design and operation of the UK-wide Deciphering Developmental Disorders (DDD) Study since 2011. The DDD Study involves scientists sequencing the ... |
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New genetic research provides hope for families with rare diseases - the Irish News
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Genetic driver behind rare skeletal dysplasia condition found – Baylor College of Medicine News (press release)
Posted: at 9:49 pm
Researchers in the Department of Molecular and Human Genetics at Baylor College of Medicine have identified a previously unimplicated gene behind a particular form of chondrodysplasia, a skeletal dysplasia that affects cartilage formation and causes disproportionate short stature and premature osteoarthritis. The study appears in the Journal of Clinical Investigation.
Stemming from research being performed at Baylor and its genetics department as part of a systematic search for genetic causes of skeletal dysplasias, the project set out to identify the genetic driver behind Shohat type spondyloepimetaphyseal dysplasia (SEMD). It was led by Dr. Brendan Lee, professor and chair of molecular and human genetics at Baylor, and a team of researchers including project leader Adetutu Egunsola, a genetics graduate student.
SEMD is a rare type of skeletal dysplasia that impacts the development of cartilage and results in a form of dwarfism, characterized by a particular pattern of joint abnormalities, scoliosis and defects of the long bones.
Through combined whole exome sequencing and studies in zebrafish and mice, Lee and his team were able to identify a completely new gene associated with this skeletal dysplasia, DDRGK1, and discovered how it functions in cartilage. In zebrafish, for example, a DDRGK1 deficiency disrupts craniofacial cartilage development and causes a decrease in levels of the protein SOX9.
Not only did we discover the requirement of DDRGK1 in maintaining cartilage, but we also found that it to be a regulator of SOX9, which is the master transcription factor that controls cartilage formation the human skeleton, said Lee, who also holds the Robert and Janice McNair Endowed Chair in molecular and human genetics. If you do not have the SOX9 protein, you do not have cartilage it drives the production of cartilage in growth plates and joint cartilage all over the body.
The relationship between DDRGK1 and SOX9 reveals a novel mechanism that regulates chondrogenesis, or cartilage maintenance and formation, by controlling SOX9 ubiquitination, a process that controls the degradation of proteins like SOX9. Loss of the function of DDRGK1 causes this cartilage dysplasia in part via accelerated destruction of SOX9.
Studying this skeletal dysplasia resulted in the biological insight about this gene that had never been implicated in any disease condition related to the skeleton, Lee said. The future is to find out whether DDRGK1s function more globally controls ubiquitination in general and to determine how this process could be targeted for treating patients with dwarfism.
Other contributors to this work include Richard Gibbs, Adetutu T. Egunsola, Yangjin Bae, Ming-Ming Jiang, David S. Liu, Yuqing Chen-Evenson, Terry Bertin, Shan Chen and James T. Lu with Baylor, Nurit Magal with Rabin Medical Center, Annick Raas-Rothschild with Sheba-Tel Hashomer Medical Center, Eric C. Swindell with the University of Texas Graduate School of Biomedical Sciences, Lisette Nevarez and Daniel H. Cohn with the University of California, Philippe M. Campeau with the University of Montreal and Mordechai Shohat with the Sackler School of Medicine at Tel Aviv University.
This research was supported by the BCM Intellectual and Developmental Disabilities Research Center and a Program Project grant from the Eunice and Kennedy Shiver National Institute of Child Health and Human Development, the BCM Advanced Technology Cores with funding from the NIH, the Rolanette and Berdon Lawrence Bone Disease Program of Texas, the BCM Center for Skeletal Medicine and Biology and Tel Aviv University.
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Gene activity in the nose may signal lung cancer – KFGO
Posted: at 9:49 pm
Tuesday, March 07, 2017 5:23 p.m. CST
By Will Boggs MD
(Reuters Health) - Genetic changes in the cells lining the inside of the nose might someday help doctors diagnose lung cancer, a recent study suggests.
The idea that you don't have to sample the disease tissue but can diagnose presence of disease using relatively accessible cells that are far from the tumor . . . is a paradigm that can impact many cancers, Dr. Avrum Spira from Boston University School of Medicine, a member of the study team, told Reuters Health by email.
The layer of cells that covers the surfaces of the body and lines the cavities is known as the epithelium. Researchers found that distinctive changes in gene activity in the nasal epithelium of lung cancer patients closely parallel the changes seen in lung epithelium and can distinguish between benign lung disease and cancer.
"I think the most interesting finding was the genomic changes in the nasal epithelium of lung cancer patients mirror so closely those found in the lower airway, Spira said.
The researchers thought the nose would be a reasonable surrogate for the field of injury in the bronchial airway, he added, but the surprisingly strong concordance between the nose and lower airway gave them the encouragement to develop a nasal biomarker for lung cancer detection.
Pulmonary nodules represent a growing diagnostic dilemma in the U.S. as we have started to screen for lung cancer, Spira said. A nasal swab that is highly sensitive for lung cancer in this setting would enable physicians to avoid unnecessary invasive biopsies in nodule patients who are unlikely to have lung cancer.
Past research has found that gene expression profiles from normal bronchial epithelial cells can distinguish smokers and former smokers with lung cancer from individuals with benign lung disease, and that nasal and bronchial epithelium respond similarly to tobacco smoke.
Spiras team sought to determine whether cancer-associated gene expression in the nasal epithelium might be useful for detecting lung cancer in current and former smokers.
They identified 535 genes that had different activity patterns in the nasal epithelium of patients with lung cancer versus those with benign disease.
Cancer-associated gene changes correlated significantly between nasal epithelium and bronchial epithelium samples, and the genes that were more active in nasal epithelium of patients with lung cancer were among the genes whose activity was most increased in bronchial epithelium of patients with cancer.
When researchers compared models doctors might use to determine the likelihood of lung cancer, nasal gene activity was more accurate than clinical risk factors alone for diagnosing lung cancer, according to the Journal of the National Cancer Institute report.
The combination of clinical factors and gene activity score accurately predicted cancer 91 percent of the time, compared to 79 percent for the model based on risk factors. The combined model also had 85 percent accuracy differentiating lung cancer from benign disease, compared to 73 percent.
One of the big-picture messages for physicians is that molecular tests like this one are emerging as part of precision medicine approaches for early cancer detection, Spira said.
SOURCE: http://bit.ly/2mdEWcl Journal of the National Cancer Institute, online February 27, 2017.
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Politically Incorrect | Criminal Case Wiki | Fandom powered …
Posted: at 9:49 pm
Politically Incorrect is a case featured in Criminal Case as the one hundred sixty-eighth case of the game. It is the fifty-third case of the game's World Edition (Season 3) and also the fifth case to take place in North America.
The Bureau went to Camp Rushmore to inform President James Hewett of SOMBRA's existence while President Hewett consulted foreign dignitaries regarding the conflict between the USNay and USStay movements. Upon reaching the campgrounds, Sidney Hirsch of the Department of Homeland Security informed the team of Special Agent Jonathan Stafford's murder. On Lake Rushmore, Jack and the player found Stafford's body with a bullet wound in his chest.
Mid-investigation, the team stopped everyone from leaving the campgrounds. Later,Agent Riordan of the FBI attempted to take over the investigation, leaving the team with 12 hours to investigate. Moreover, the President denied SOMBRA's existence and went as far as refusing to talk about the organization. The team was able to collect enough evidence to arrest Sidney for the murder.
Initially denying involvement, Sidney admitted that he had shot the man he loved. He said that he was jealous because of Jonathan's affair with First Lady Olivia Hewett and that he had confessed his feelings to him while having lunch. When Jonathan had pushed him away and called him old, Sidney shot him in the chest with his rifle and tried to resuscitate Jonathan after realizing what he had done. Consequently,Judge Adaku sentenced him to 18 years in jail.
Following Sidney's trial, the team tried to convince the President to take SOMBRA's threat seriously. Hewett still refused to talk about SOMBRA, but directed the team to the conference room for a file that the president of Russia had previously given him. Inside a COSMORUSsafebox, they found a pen drive which (per Elliot) contained information about BB, SOMBRA's captured satellite. Elliot thought of retrieving the code that SOMBRA intended to use to hijack all the satellites in the world so the team could show it to the world leaders. In order to retrieve it, the team requested Sidney's help to control BB, having it to land on Earth and pulling the hard drive out of it. During BB's descent, however, someone hijacked the satellite and rerouted it to the Northern Canadian wilderness.
After Carmen helped Sanjay meet his (and Elliot's) idol, Vanna Alabama, the Bureau headed to northern Canada to investigate BB's hijacking.
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Gene Frenette: Forget sad goodbyes for Rogers, be grateful for epic coaching career – Florida Times-Union
Posted: at 9:49 pm
There was no game plan for Corky Rogers farewell press conference Tuesday, so the legendary football coach essentially winged it. He answered a few questions and then regaled his audience at a Bolles School auditorium with multiple stories, including the politically incorrect variety, about a magnificient football life.
It was Rogers at his unfiltered best for 39 minutes, as if he were entertaining friends at one of his Friday night postgame parties. At one point, to emphasize wanting to stay active in some capacity with Bolles football, he said: If they want me to be a ballboy, Ill be a ballboy.
The 73-year-old Rogers, being forced to step down as head coach at The Bolles School due to lingering health problems, purposely avoided turning this awkward goodbye into a solemn occasion. Though his body has betrayed him the last nine months, Rogers wants no sympathy for being dealt a tough hand of not leaving the profession on his terms.
A look back: Corky Rogers through the years
Thats the way me and everybody else on the [coaching] staff feels, Rogers said. Its not a bad time, its just THE time [to step away]. Would I have liked to go on coaching? Sure, but who wouldnt? Its just one of those things. Thats life.
Im glad for what I had. It went a lot longer than I thought itd go on. Theres nothing but good things to remember.
Nobody could have predicted when a newly-married Rogers, two years removed from his Georgia Tech playing days, left the insurance business in 1968 that it would lead to one of the epic coaching careers in high school football history.
Through sheer force of his competitive drive, Rogers imposed a will of voracious preparation on nearly 2,000 players in 17 years at Lee High School and the last 28 seasons at Bolles. It led to a payoff of 465 victories, 10 state titles, and teenagers receiving much-needed direction on their path to manhood.
While his career end was abrupt, and quite sad for many of his colleagues, Rogers wasnt about to stop coaching. So he kept the message upbeat by thanking players, coaches past and present, and his immediate family (wife Linda, daughters Tracy and Jennifer). He repeatedly emphasized his success was a team effort, not a solo act.
But the more Rogers deflected credit, the more a small audience of former Bolles administrators and ex-players paid him homage. A Bolles psychology teacher for 24 years, Melissa Tyler, lauded him for having football players in her class that were well-behaved and respectful.
Shawn Puri, a former Lee lineman and almost-retired Jacksonville police officer that has served as Rogers security guard at hundreds of games, kept his message short and on point, saying: On behalf of the thousand of guys that couldnt be here thank you.
About a half-dozen current Bolles players slipped into the auditorium in-between classes to hear their coach. Unsolicited, Rogers brought 6-foot-9 junior offensive tackle Nick Lewis on stage, introducing him like a proud father for being offered a scholarship to Missouri.
Harvard-bound senior defensive end Justin Mitchell sat quietly, then might well have spoken for every player who endured Rogers hard-driving regimen of practices to his offseason conditioning program. He smiled when Rogers talked about his long-standing tradition of wearing white socks pulled up, knowing players who strayed from that fashion edict were immediately kicked out of practice.
I loved playing for him because he taught you so much, said Mitchell. Coach Rogers has been through a lot [health-wise] and I listen to every story he tells because I feel it teaches you something about life. This football program has taught me how to be a man. I just thank him for that.
It was another reminder of how much Rogers transcends time. Whether it was baby boomers, Generation X, Y or Millenials, his message to players from all walks of life got through in a way that maximized their talent.
Its a shame someone of Corky Rogers skill level will no longer roam a football sideline as a head coach, but his friends, coaching colleagues and players have little reason to be sad. The overriding sentiment should be an appreciation for five decades of what he was able to give them.
Gene.frenette@jacksonville.com: (904) 359-4540
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Censorship in India – Wikipedia
Posted: at 9:48 pm
In general, censorship in India, which involves the suppression of speech or other public communication, raises issues of freedom of speech, which is protected by the Indian constitution.
The Constitution of India guarantees freedom of expression but places certain restrictions on content, with a view towards maintaining communal and religious harmony, given the history of communal tension in the nation.[1] According to the Information Technology Rules 2011, objectionable content includes anything that threatens the unity, integrity, defence, security or sovereignty of India, friendly relations with foreign states or public order".[2]
In 2017, the Freedom in the World report by Freedom House gave India a freedom rating of 2.5, a civil liberties rating of 3, and a political rights rating of 2, earning it the designation of free. The rating scale runs from 1 (most free) to 7 (least free).[3] Analysts from Reporters Without Borders rank India 133rd in the world in their 2016 Press Freedom Index,[4] In 2016, the report Freedom of the Press by Freedom House gave India a press freedom rating of "Partly Free", with a Press Freedom Score of 41 (0-100 scale, lower is better).[5]
Watching or possessing pornographic materials is apparently legal, however distribution of such materials is strictly banned.[6] The Central Board of Film Certification allows release of certain films with sexual content (labelled A-rated), which are to be shown only in restricted spaces and to be viewed only by people of age 18 and above.[7] India's public television broadcaster, Doordarshan, has aired these films at late-night timeslots.[8]Films, television shows and music videos are prone to scene cuts or even bans, however if any literature is banned, it is not usually for pornographic reasons. Pornographic magazines are technically illegal, but many softcore Indian publications are available through many news vendors, who often stock them at the bottom of a stack of non-pornographic magazines, and make them available on request. Most non-Indian publications (including Playboy) are usually harder to find, whether softcore or hardcore. Mailing pornographic magazines to India from a country where they are legal is also illegal in India. In practice, the magazines are almost always confiscated by Customs and entered as evidence of law-breaking, which then undergoes detailed scrutiny.
The Official Secrets Act 1923 is used for the protection of official information, mainly related to national security.[9]
The Indian Press currently enjoys extensive freedom. The Freedom Of Speech, mandated by the constitution guarantees and safeguards the freedom of press. However, the freedom of press was not always as robust as today.[citation needed] In 1975, the Indira Gandhi government imposed censorship of press during The Emergency. It was removed at the end of emergency rule in March 1977.[10] On 26 June 1975, the day after the emergency was imposed, the Bombay edition of The Times of India in its obituary column carried an entry that read, "D.E.M O'Cracy beloved husband of T.Ruth, father of L.I.Bertie, brother of Faith, Hope and Justica expired on 26 June".[11] In 1988 defamation bill introduced by Rajiv Gandhi but it was later withdrawn due to strong opposition to it .[12]
On 2 October 2016 (see: 2016 Kashmir unrest) the Srinagar-based Kashmiri newspaper, Kashmir Reader was asked to stop production by the Jammu and Kashmir government. The ban order, issued by the Deputy Commissioner of Srinagar Farooq Ahmad Lone cited that the reason for this was that the newspaper contains material and content which tends to incite acts of violence and disturb public peace and tranquility[13] The ban came after weeks of unrest in the Kashmir valley, following the killing of the militant Burhan Wani. Journalists have decried this as a clampdown on freedom of expression and democracy in Kashmir, as a part of the massive media censorship of the unrest undertaken by the central government. Working journalists protested the ban by marching to the Directorate of Information and Public Relations while the Kashmir Editors Guild (KEG) held an emergency meeting in Srinagar, thereafter asking the government to revoke the ban immediately, and asking for the intervention of the Press Council of India.[13] The move has been criticised by a variety of individuals, academic and civil groups in Kashmir and international rights groups, such as Jammu and Kashmir Coalition of Civil Society (JKCCS), Kashmir Economic Alliance (KEA), the Kashmir Center for Social and Developmental Studies (KCSDS) and Amnesty International, among others. Most of the major Kashmiri dailies have also rallied behind the KR, while claiming that the move represented a political vendetta against the newspaper for reporting events in the unrest as they happened on the ground. Hurriyat leaders, known to champion the cause of Kashmiri independence, also recorded their protests against the banning of the newspaper. Amnesty International released a statement saying that "the government has a duty to respect the freedom of the press, and the right of people to receive information,"[14] while criticising the government for shutting down a newspaper for opposing it. The journalists associated with the paper allege that, contrary to the claims of the J&K government, they had not been issued a notice or warning, and had been asked to stop production suddenly, which was only one manifestation of the wider media gag on Kashmir. Previously, the state government had banned newspapers for a few days in July, calling the move a temporary measure to address an extra-ordinary situation,[13] only to deflect the blame onto the police upon facing tremendous backlash, and thereafter asking the presses to resume publication. As of October 5, 2016, the ban has not been revoked and local journalists continue to protest against what they see as a breach of the freedom of the press and freedom of speech in Kashmir, with no official meeting forthcoming with government functionaries.
The Supreme Court while delivering judgement in Sportsworld case in 2014 held that "A picture of a nude/semi-nude woman... cannot per se be called obscene".[12]
The Central Board of Film Certification, the regulatory film body of India, regularly orders directors to remove anything it deems offensive, including sex, nudity, violence or subjects considered politically subversive.[15]
According to the Supreme Court of India:[16]
In 2002, the film War and Peace, depicting scenes of nuclear testing and the September 11, 2001 attacks, created by Anand Patwardhan, was asked to make 21 cuts before it was allowed to have the certificate for release.[17][18] Patwardhan objected, saying "The cuts that they asked for are so ridiculous that they won't hold up in court" and "But if these cuts do make it, it will be the end of freedom of expression in the Indian media." The court decreed the cuts unconstitutional and the film was shown uncut.
In 2002, the Indian filmmaker and former chief of the country's film censor board, Vijay Anand, kicked up a controversy with a proposal to legalise the exhibition of X-rated films in selected cinemas across the country, saying "Porn is shown everywhere in India clandestinely ... and the best way to fight this onslaught of blue movies is to show them openly in theatres with legally authorised licences".[15] He resigned within a year after taking charge of the censor board after facing widespread criticism of his moves.[19]
In 2003, the Indian Censor Board banned the film Gulabi Aaina (The Pink Mirror), a film on Indian transsexuals produced and directed by Sridhar Rangayan. The censor board cited that the film was "vulgar and offensive". The filmmaker appealed twice again unsuccessfully. The film still remains banned in India, but has screened at numerous festivals all over the world and won awards. The critics have applauded it for its "sensitive and touching portrayal of marginalised community".[20][21][22]
In 2004, the documentary Final Solution, which looks at religious rioting between Hindus and Muslims, was banned.[23][24] The film follows 2002 clashes in the western state of Gujarat, which left more than 1,000 people dead. The censor board justified the ban, saying it was "highly provocative and may trigger off unrest and communal violence". The ban was lifted in October 2004 after a sustained campaign.[25]
In 2006, seven states (Nagaland, Punjab, Goa, Tamil Nadu, Andhra Pradesh) have banned the release or exhibition of the Hollywood movie The Da Vinci Code (and also the book),[26] although India's Central Board of Film Certification cleared the film for adult viewing throughout India.[27] However, the respective high courts lifted the ban and the movie was shown in the two states.
In 2013, Kamal Haasan's "Vishwaroopam" was banned from the screening for a period of two weeks in Tamil Nadu.[12]
The Central Board of Film Certification demanded five cuts from the 2011 American film The Girl with the Dragon Tattoo because of some scenes containing rape and nudity. The producers and the director David Fincher finally decided not to release the film in India.[28]
In 2015, the Central Board of Film Certification demanded four cuts (three visual and one audio) from the art-house Malayalam feature film Chaayam Poosiya Veedu (The Painted House) directed by brothers Santosh Babusenan and Satish Babusenan because the film contained scenes where the female lead was shown in the nude. The directors refused to make any changes whatsoever to the film and hence the film was denied a certificate.[29][30][31][32][33]
In 2016, the film Udta Punjab, produced by Anurag Kashyap and Ekta Kapoor among others, ran into trouble with the Central Board of Film Certification, resulting in a very public re-examination of the ethics of film censorship in India. The film, which depicted a structural drug problem in the state of Punjab, used a lot of expletives and showed scenes of drug use. The CBFC, on 9 June 2016, released a list of 94 cuts and 13 pointers, including the deletion of names of cities in Punjab. On 13 June 2016, Udta Punjab was cleared by the Bombay High Court with one cut and disclaimers. The court ruled that, contrary to the claims of the CBFC, the film was not out to "malign" the state of Punjab, and that it wants to save people[34] Thereafter, the film was faced with further controversy when a print of it was leaked online on a torrent site. The quality of the copy, along with the fact that there was supposedly a watermark that said "censor" on top of the screen, raised suspicions that the board itself had leaked the copy to spite the filmmakers. It also contained the only scene that had been cut according to the High Court order. While the censor board claimed innocence,[35] the lingering suspicions resulted in a tense release, with the filmmakers and countless freedom of expression advocates taking to social media to appeal to the public to watch the film in theatres, as a conscious challenge against excessive censorship on art in India. Kashyap himself asked viewers to wait till the film released before they downloaded it for free, stating that he didn't have a problem with illegal downloads,[36] an unusual thing for a film producer to say. The film eventually released and grossed over $13 million[37] finishing as a commercial success.
Heavy metal band Slayer's 2006 album Christ Illusion was banned in India after Catholic churches in the country took offence to the artwork of the album and a few song titles and launched a protest against it. The album was taken off shelves and the remaining catalog was burnt by EMI Music India.[38]
In 1999, Maharashtra government banned the Marathi play Me Nathuram Godse Boltoy or I, Nathuram Godse, Am Speaking[39] The Notification was challenged before the Bombay High Court, and the High Court Bench consisting of B. P. Singh (Chief Justice), S. Radhakrishnan, and Dr. D. Y. Chandrachud allowed the writ petition and declared the notification to be ultra vires and illegal, thus rescinding the ban.
In 2004, Eve Ensler's The Vagina Monologues was banned in Chennai. The play however, has played successfully in many other parts of the country since 2003. A Hindi version of the play has been performing since 2007.
In 1961, it was criminalised in India to question the territorial integrity of frontiers of India in a manner which is, or is likely to be, prejudicial to the interests of the safety or security of India.[40]
Freedom House's Freedom on the Net 2015 report gives India a Freedom on the Net Status of "Partly Free" with a rating of 40 (scale from 0 to 100, lower is better). Its Obstacles to Access was rated 12 (0-25 scale), Limits on Content was rated 10 (0-35 scale) and Violations of User Rights was rated 18 (0-40 scale).[56] India was ranked 29th out of the 65 countries included in the 2015 report.[57]
The India country report that is included in the Freedom on the Net 2012 report, says:[58]
India is classified as engaged in "selective" Internet filtering in the conflict/security and Internet tools areas and as showing "no evidence" of filtering in the political and social areas by the OpenNet Initiative in May 2007.[59] ONI states that:
As a stable democracy with strong protections for press freedom, Indias experiments with Internet filtering have been brought into the fold of public discourse. The selective censorship of Web sites and blogs since 2003, made even more disjointed by the non-uniform responses of Internet service providers (ISPs), has inspired a clamour of opposition. Clearly government regulation and implementation of filtering are still evolving. Amidst widespread speculation in the media and blogosphere about the state of filtering in India, the sites actually blocked indicate that while the filtering system in place yields inconsistent results, it nevertheless continues to be aligned with and driven by government efforts. Government attempts at filtering have not been entirely effective, as blocked content has quickly migrated to other Web sites and users have found ways to circumvent filtering. The government has also been criticised for a poor understanding of the technical feasibility of censorship and for haphazardly choosing which Web sites to block. The amended IT Act, absolving intermediaries from being responsible for third-party created content, could signal stronger government monitoring in the future.[59]
A "Transparency Report" from Google indicates that the Government of India initiated 67 content removal requests between July and December 2010.[60]
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Violence on Facebook Live presents censorship dilemma – CNET – CNET
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Video live-streamed on Facebook in June showed the action that precedes a shooting, as well as the aftermath.
Facebook Live gives people an easy way to broadcast live video, but it has also reportedly given Facebook a real live headache: how to decide when to censor video depicting violent acts.
In the year since its launch, the feature has been used to broadcast at least 50 acts of violence, according to the Wall Street Journal, including murder, suicides and a beating of a special-needs teenager in Chicago earlier this year. One of the problems is that Facebook "didn't grasp the gravity of the medium" during the planning process for the feature, an unidentified source told the newspaper.
Facebook Live, which lets anyone with a phone and internet connection live-stream video directly to Facebook's 1.8 billion users, has become a centerpiece feature for the social network. In the past few months, everyone from Hamilton cast members to the Donald Trump campaign has turned to Facebook to broadcast in real time.
"Soon, we believe a camera will be the main way to share," instead of the traditional text box, Facebook CEO Mark Zuckerberg said during an earnings conference call last November. "We think its pretty clear video is only going to become more important."
But the focus on video has prompted some tough philosophical questions, like what Facebook should and shouldn't show.
In July, a Minnesota woman named Diamond Reynolds used the service to live-stream her fiance Philando Castile after he was shot by police. The next day, Facebook Live captured the scene as five Dallas police officers were gunned down during a peaceful demonstration.
Both the Castile and Dallas videos were initially streamed unedited and uncensored. The Castile video temporarily disappeared from the social network because of a "technical glitch," according to Facebook. It was restored later with a warning about its graphic nature.
Zuckerberg addressed this issue last month in an open letter to the Facebook community, conceding that errors in judgment were made.
"In the last year, the complexity of the issues we've seen has outstripped our existing processes for governing the community," he wrote, referencing how some newsworthy videos were handled.
Facebook did not immediately respond to a request for comment.
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Students journalists gain protection against censorship – Arizona Daily Sun
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PHOENIX A House panel voted 10-1 Monday to protect student journalists despite objections by one lawmaker who feared giving too much power to children.
SB 1384 would limit the ability of administrators to censor university, community college and public school papers. About the only time they could block publication would be in cases of libel, unwarranted invasions of privacy, violations of law of where there is imminent danger of inciting students or disruption of operations.
And that prior restraint would be allowed only for public school papers.
Members of the House Education Committee heard from a parade of high school journalists who cited their own experiences having stories edited or quashed by administrators. That included Henry Gorton at Sunnyslope High School who said he was barred from reporting the views of Trump supporters about issues of illegal immigration amid concerns that undocumented students would feel threatened.
Rep. Don Shooter, R-Yuma, told Gorton that story might actually gain him support at the Republican-controlled legislature.
But Rep. David Stringer, R-Prescott, called the legislation well intentioned but also flawed.
Stringer indicated he had no real problem with providing protections for college journalists. But this bill, he said, goes too far.
I think it's a big mistake to include high schools and student newspapers in high schools with colleges and universities, he said. There's a very, very fundamental difference between high schools which are full of children, which are full of minors, and colleges and universities where we're dealing with adults.
And Stringer specifically objected to a provision to protect faculty advisers from administrative retaliation solely for either protecting student journalists from exercising their rights in the legislation or refusing to infringe on conduct that is constitutionally protected.
I can see the need to protect students, to allow students to have freedom of speech, he told Sen. Kimberly Yee, R-Phoenix, the sponsor of the legislation.
But I think it's pretty common knowledge that in many of our schools there's a strong liberal bias, Stringer continued. And I can foresee the unintended consequence of protecting faculty members who are influencing the students, or perhaps expressing their own views and biases, using public resources to propagandize their own liberal views through what purport to be student publications.
Stringer was not dissuaded by Lori Hart, a faculty adviser at Cactus Shadows High School in Cave Creek, who argued such protections are necessary.
Advisers do get fired from teaching at the school if they go ahead and publish something that is not approved by the school, she said.
Hart said it's possible that if students get additional legal protections it might not be necessary to extend some sort of employment immunity to their advisers. But she told Stringer that's not the case now.
I just know that right now teachers need that protection, Hart said.
This is actually the second time Yee has advanced such legislation. The first time was in 1992 as a high school student journalist who came to the Capitol to seek protections after she said her own work at Greenway High School was being censored.
She got the bill through the Senate only to have it die in the House. Yee told colleagues she did not realize that until last year.
Yee, like Hart, defended the protection for faculty members.
They, too, receive intimidation from their school district administrators who tell them, 'Don't print the story, she said.
And they fight against that because they're protecting the student, Yee said. They're saying, 'The story is a valid story, it's got both sides of the issue, it's black and white, it's appropriate to go to print.
Stringer warned Gorton there's a potential downside in getting the freedom he and other students seek: Administration simply shutters the paper.
You do see the risk that if we statutorily guarantee you, to high school students, adolescents, this blanket kind of immunity and free speech protection that it could be totally self-defeating and have very unintended consequences that you basically lose your forum for expressing any opinions or journalistic ideas, Stringer said.
Gorton, however, was undeterred. He said if administration controls the content, the paper is no longer a forum for students.
Under censorship, it's not a forum but an echo chamber that's more propaganda and more a newsletter rather than a newspaper, something that only advances the interests of our administrators, he said.
Rep. Michelle Udall, R-Mesa, said she was concerned that the legislation did not specifically allow administrators to keep profanity and nudity out of papers. But David Cullier, dean of the journalism school at the University of Arizona, said there are court cases which already give public school administrators the right to prevent publication of such items.
The measure, which already has gained unanimous Senate approval, now needs a vote of the full House.
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