Monthly Archives: March 2017

Scientists store digital files in an unlikely place: DNA – Mashable

Posted: March 7, 2017 at 9:53 pm

Scientists store digital files in an unlikely place: DNA
Mashable
A new coding technique could make it possible to condense your entire digital library onto a microscopic hard drive. Except the hard drive won't consist of metals and plastic. It will be made of DNA. Scientists in New York have developed a way to ...
A film, a computer operating system, a virus AND an Amazon gift card are all stored on a single piece of DNADaily Mail
Scientists develop DNA storage that could 'store world's data in a single room'the Irish News

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Scientists store digital files in an unlikely place: DNA - Mashable

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DNA Motors in Living Cells Start with MicroRNA Keys – Genetic Engineering & Biotechnology News (blog)

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Its hard enough to get a synthetic DNA motor to run in a living celland not just in a test tubebut its even harder to get the DNA motor to start only when it might be needed. Yet DNA motors built by scientists at the University of Alberta have been running smoothly inside cancer cells. Also, each of these molecular engines didnt turn over until its specially designed ignition mechanism received the right key, in this case a cancer-associated microRNA (miRNA).

This resulta demonstration that a synthetic molecular engine may be started by a specific intracellular targetcould encourage scientists to develop diverse diagnostic and drug-delivery applications.

The nanomachine was built from compartments made up of DNA enzyme molecules and substrates. According to its builders, the nanomachine has the required fuels, DNA tracks, and a molecular switch. Additional details of the nanomachines construction appeared March 6 in the journal Nature Communications, in an article entitled, A MicroRNA-Initiated DNAzyme Motor Operating in Living Cells.

The whole motor system is constructed on a 20nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand, wrote the articles authors. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP.

In the current study, the nanomachine was tuned to detect a specific miRNA sequence found in breast cancer cells. When it came into contact with the targeted molecules, the DNA motor was turned on and produced fluorescence as part of a reaction. The researchers were able to monitor the fluorescence, detecting which cells were cancerous.

"We want to be able to detect cancer or disease markers in very minute amounts before the disease gets out of hand, said Chris Le, Ph.D., Canada Research Chair and a distinguished university professor of laboratory medicine and pathology. That way physicians can attack it very early. The trace amount of the target molecules that may be missed by other techniques can now be detected with this one."

In addition to citing the potential for improved disease diagnosis, the researchers asserted that DNA motors could also be used for precision drug delivery in patients. Conventional targeted drug therapy delivers medicine to a selectively targeted site of action, yet it still affects a large number of molecules that are not diseased. With the DNA motor, the team says a drug payload can be delivered and then released only when triggered by disease-specific molecules.

"You still have some drug molecules going to the normal cellsyou can't avoid that," noted Dr. Le. "Using the DNA motor, we hope to deliver the drug into the cells in an inactive form. Only when the DNA motor encounters the targeted molecules can the drug then be released to be active."

While the team used a breast cancer marker for the study, the aim now is to expand the work to examine a wider range of other disease markers. Further testing on the nanomachines is needed to better understand the full range of capabilities for drug delivery.

The response of the DNAzyme motor is not limited to the miR-10b miRNA [used in this study], the authors of the Nature Communications article indicated. Similar motor systems can be readily constructed to respond to other miRNA and messenger RNA targets. A modification to the design can be made by simply altering the target binding domain of the locking strand. Diverse DNAzyme motors can also be designed to respond to small molecules and proteins in cells.

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DNA Motors in Living Cells Start with MicroRNA Keys - Genetic Engineering & Biotechnology News (blog)

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DNA Scan Uncovers 18 Genes Newly Associated With Autism – NBCNews.com

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Computer-generated image of DNA strands. Altayb / iStockphoto/Getty Images

Some of the mutations might be affected by medications, the researchers reported in the journal Nature Neuroscience.

The study adds to the considerable evidence that autism is a condition caused by genetics, and also adds to a growing body of evidence that each person with autism has his or her own pattern of DNA changes.

"It's noteworthy that we're still finding new autism genes, let alone 18 of them, after a decade of intense focus," said Mathew Pletcher, vice president for genomic discovery at Autism Speaks.

"With each new gene discovery, we're able to explain more cases of autism, each with its own set of behavioral effects and many with associated medical concerns."

Dr. Stephen Scherer of Toronto's Hospital for Sick Children and colleagues studied the DNA of more than 5,000 people in 2,066 families with children diagnosed with autism spectrum disorders, including 2,600 affected children.

They did what's known as a genome-wide association study a deep dive looking at all the DNA in a person's cells, and how it's different from another person's.

The 18 genes they identified have not been not previously linked with autism, but they are all involved in brain cell communications. There are many different mutations affecting the genes, the researchers said.

There are also genetic changes that don't affect genes, but that are found in stretches of DNA once called junk DNA that affect the activation of genes.

"In fact, the genetic predisposition toward autism spectrum disorder may be different for almost every individual," the team wrote.

The same team found in 2015 that even siblings with autism

Autism spectrum disorder can range from the mild social awkwardness, including Asperger's syndrome, to profound mental retardation, debilitating repetitive behaviors and an inability to communicate. There's no cure, but experiments with

Autism is becoming

Another survey found it had been diagnosed in

Studies also show it's clear that genetic mutations are responsible for many, if not most cases of autism. Infections during pregnancy also play a role, and it is possible that certain genetic mutations make children more susceptible to brain changes caused by infections in the womb.

One study found 33 new genes associated with autism, and researchers think they may eventually find 1,000 mutations.

It's already known that kids with autism have larger-than-normal brains. One hypothesis is that the growing brain of a child with autism doesn't "prune" unneeded connections properly, and the resulting overgrowth of nerve connections sends the brain into overdrive.

Another study published Monday found

In the gene study, the researchers found that all of the DNA changes affected brain cells or communication, and many of them might be affected by drugs.

"Sixteen genes contained subdomains that could be targeted by pharmaceutical intervention and seven contained subdomains for which specific drug-gene interactions are known," they wrote. For example, people with certain mutations could try drugs known as allosteric modulators of GABA receptors a class that includes diazepam, also known as Valium; the sleeping pill Ambien and barbiturates.

Autism Speaks is making the data from the project, called MSSNG (it's the missing 'I's' that matter), available freely.

"Through its research platform on the Google Cloud, Autism Speaks is making all of MSSNG's fully sequenced genomes directly available to researchers free of charge, along with analytic tools. In the coming weeks, the MSSNG team will be uploading an additional 2,000 fully sequenced autism genomes, bringing the total to (more than) 7,000."

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DNA Scan Uncovers 18 Genes Newly Associated With Autism - NBCNews.com

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Plymouth DA releases DNA-generated sketch of man wanted for rape – Turn to 10

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BROCKTON, Mass. (WJAR)

Authorities in Plymouth County asked for the public's help Tuesday in finding a man sought in connection to three rapes, as well as two murders.

A computerized composite of the suspect was created using a sample of his DNA in a process that predicts his physical appearance.

That one piece -- that DNA piece tying these cases and situations together -- is really important, District Attorney Timothy Cruz said Tuesday.

Some of the DNA was found in 2014 when police discovered two bodies stacked atop each other in a wooded area.

The same DNA was also located on three rape victims who were picked up in Brockton, beaten, and then dropped off far outside the city. Authorities noted that all the victims were prostitutes who had been picked up in the same area of downtown.

They were tossed aside like garbage, Cruz said.

However, authorities also said there's no immediate danger to the public because they don't have any evidence that the suspect has committed any crimes since 2014. They're unsure if he's gone dormant or remains active.

Either way, they want him behind bars.

No matter how much technology we have and how many resources the district attorney and the state police and Brockton police may bring to this, at the end of the day we need some help from the public, Brockton Mayor William Carpenter said.

Meanwhile, Cruz said he had the DNA image made after a standard sketch triggered few leads.

Hes hoping that changes going forward, as the DNA profile shows that the suspect had strong ties to West Africa and Western Europe, meaning that hes potentially a member of the city's large Cape Verdean community.

Anyone with information should contact the Plymouth County District Attorney's Office.

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Plymouth DA releases DNA-generated sketch of man wanted for rape - Turn to 10

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Principles of 3-D genome folding and gene expression studied across species – Phys.Org

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March 7, 2017 The evolution of globin gene domain 3-D organization exhibits a tendency to the formation of globular structures. Embryonic and adult globin genes are designated with light grey and dark grey circles, respectively. The major regulatory element (MRE) of the Danio rerio major globin gene locus and -globin gene domains of warm-blooded vertebrates is designated with red hexagon. The locus control region (LCR) of the -globin gene domains of warm-blooded vertebrates is designated with a set of red rectangles. Experimentally validated insulators and putative ones are designated with dark blue ellipses and light blue ellipses, respectively. The spatial configuration of the mouse -globin gene domain and the interaction frequency between the insulators in the chicken -globin gene domain in embryonic erythroid cells before globin expression switching are currently unknown. Credit: Razin lab

It seems like a feat of magic. Human DNA, if stretched out into one, long spaghetti-like strand, would measure 2 meters (six feet) long. And yet, all of our DNA is compacted more than 10,000 times to fit inside a single cell. How is this accomplished while preserving the overall, vital genomic organization?

With new techniques, scientists are beginning to understand the principles of 3-D genome folding. And in one of the studies of its kind, Anastasia Kovina, Sergey Razin a et al. have examined the well-studied globin gene cluster to understand the evolution of genome folding behind a vital process, delivering oxygen throughout the body.

Their study sheds light on the genomic evolutionary process that resulted in segregation of the alpha and beta-globin genes into two differently regulated domains in warm-blooded vertebrates. "We suggest that globin gene domains of some modern, cold-blooded animals retain certain features of an ancient, ancestral domain," said corresponding author Sergey Razin.

By investigating globin genes in the zebrafish model organism, their evidence points toward their suggestion that modern clusters of - and -globin genes of warm-blooded animals evolved from an ancestral locus, contained within a globular genomic cluster that was located close to other evolutionary conserved genes.

They found that evidence of a dynamic genomic organization of globin gene cluster that differs depending on the developmental age of the zebrafish. Using different assays, they have shown that the adult globin sub-compartment of the zebrafish gene locus is insulated from the embryonic larval component.

"We have found that the major globin gene locus of zebrafish (Danio rerio) is structurally and functionally segregated into two spatially distinct subloci harboring either adult or embryo-larval globin genes," said Razin. "These subloci demonstrate different organization at the level of chromatin domains and different modes of spatial organization, which appears to be due to selective interaction of the upstream gene enhancer with the sublocus harboring globin genes of the adult type."

This organization drastically differs from that of the mammalian - and -globin gene domains, where both embryo-fetal and adult globin genes are recruited to the same regulatory elements in a developmental and stage-specific process.

The finding of a functional separation of adult and embryo globin genes reflected in the 3-D genomic organization chromatin will provide an important contribution to the field and interesting evolutionary perspective to how gene clusters are organized and expressed.

Explore further: Researchers find potential treatments for hemoglobinopathies

More information: Evolution of the genome 3D organization: comparison of fused and segregated globin gene clusters, Molecular Biology and Evolution (2017).

An article published in Experimental Biology and Medicine (Volume 242, Issue 3, February, 2017) identifies microRNAs (miRNAs) as key factors in some hemoglobinopathies, genetic disorders characterized by alterations in the ...

Promising results from the first clinical trials of globin gene transfer to treat beta-thalassemias-inherited forms of anemia-have eliminated the need for blood transfusions in some individuals. Enhancing current gene therapy ...

Scientists at Karolinska Institutet in collaboration with Estonian Competence Centre on Health Technologies have developed a new gene expression analysis method to widen the usage of blood in biomarker discovery and analysis. ...

In biology, free radicals are often regarded as the source of all evil and the major cause of molecular damage and aging. However, free radicals are indispensable as signaling molecules governing important functions in the ...

Genetic mutations that affect our blood cells' haemoglobin are the most common of all mutations. It has been estimated that around 5% of the world's population carry a defective globin gene.

UCLA stem cell researchers have shown that a novel stem cell gene therapy method could lead to a one-time, lasting treatment for sickle cell diseasethe nation's most common inherited blood disorder.

Scientists are beginning to realize that many cellular behaviors, such as metastasizing cancer cells moving through the body or wound healing, aren't random events, but the result of coordinated actions by cells.

Scientists at Baylor College of Medicine, the Lawrence Berkeley National Laboratory, Massachusetts Institute of Technology and Purdue University have completed a model of unprecedented near-atomic resolution of the chemical ...

Black swan events are rare and surprising occurrences that happen without notice and often wreak havoc on society. The metaphor has been used to describe banking collapses, devastating earthquakes and other major surprises ...

The speed at which a tiny ant evolves to cope to its warming city environment suggests that some species may evolve quickly enough to survive, or even thrive, in the warmer temperatures found within cities, according to a ...

While there are already a number of species named after famous British broadcaster and naturalist Sir David Attenborough, including mammals, reptiles, invertebrates and plants, both extinct and extant, not until now has the ...

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Stream of surprises from the Atlantic cod genome – Science Daily

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Science Daily

Stream of surprises from the Atlantic cod genome
Science Daily
The Atlantic cod genome consists of approximately 700 million pairs of DNA bases (remember that the DNA molecule is a double helix with matching base pairs on each strand). With the recent study, the researchers have now surveyed a total of 93 per cent ...

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Stream of surprises from the Atlantic cod genome - Science Daily

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World’s largest autism genome database shines new light on many ‘autisms’ – Medical Xpress

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March 7, 2017 Quinn, an autistic boy, and the line of toys he made before falling asleep. Repeatedly stacking or lining up objects is a behavior commonly associated with autism. Credit: Wikipedia.

The newest study from the Autism Speaks MSSNG project - the world's largest autism genome sequencing program - identified an additional 18 gene variations that appear to increase the risk of autism.

The new report appears this week in the journal Nature Neuroscience. It involved the analysis of 5,205 whole genomes from families affected by autism - making it the largest whole genome study of autism to date.

The omitted letters in MSSNG (pronounced 'missing') represent the missing information about autism that the research program seeks to deliver.

"It's noteworthy that we're still finding new autism genes, let alone 18 of them, after a decade of intense focus," says study co-author Mathew Pletcher, Ph.D., Autism Speaks' vice president for genomic discovery. "With each new gene discovery, we're able to explain more cases of autism, each with its own set of behavioral effects and many with associated medical concerns."

To date, research using the MSSNG genomic database has identified 61 genetic variations that affect autism risk. The research has associated several of these with additional medical conditions that often accompany autism. The goal, Dr. Pletcher says, "is to advance personalized treatments for autism by deepening our understanding of the condition's many subtypes."

The findings also illustrate how whole genome sequencing can guide medical care today. For example, at least two of the autism-associated gene changes described in the paper were associated with increased risk for seizures. Another has been linked to increased risk for cardiac defects, and yet another with adult diabetes. The findings illustrate how whole genome sequencing for autism can provide additional medical guidance to individuals, families and their physicians, the investigators say.

The researchers also determined that many of the 18 newly identified autism genes affect the operation of a small subset of biological pathways in the brain. All of these pathways affect how brain cells develop and communicate with each other. "In all, 80 percent of the 61 gene variations discovered through MSSNG affect biochemical pathways that have clear potential as targets for future medicines," Dr. Pletcher says.

Increasingly, autism researchers are predicting that personalized, more effective treatments will come from understanding these common brain pathways - and how different gene variations alter them.

"The unprecedented MSSNG database is enabling research into the many 'autisms' that make up the autism spectrum," says the study's senior investigator, Stephen Scherer, Ph.D.

For instance, some of the genetic alterations found in the study occurred in families with one person severely affected by autism and others on the milder end of the spectrum, Dr. Scherer notes. "This reinforces the significant neurodiversity involved in this complex condition," he explains. "In addition, the depth of the MSSNG database allowed us to identify resilient individuals who carry autism-associated gene variations without developing autism. We believe that this, too, is an important part of the neurodiversity story."

Dr. Scherer is the research director for the MSSNG project and directs The Centre for Applied Genomics at the Hospital for Sick Children (SickKids), in Toronto. MSSNG is a collaboration between the hospital, Autism Speaks and Verily (formerly Google Life Sciences), which hosts the MSSNG database on its cloud platform.

Traditional genetic analysis looks for mutations, or "spelling changes," in the 1 percent of our DNA that spells out our genes. By contrast, the MSSNG database allows researchers to analyze the entire 3 billion DNA base pairs that make up each person's genome.

In their new study, the investigators went even further - looking beyond DNA "spelling" variations to find other types of genetic changes associated with autism. These included copy number variations (repeated or deleted stretches of DNA) and chromosomal abnormalities. Chromosomes are the threadlike cell structures that package and organize our genes.

The researchers found copy number variations and chromosomal abnormalities to be particularly common in the genomes of people affected by autism.

In addition, many of the copy number variations turned up in areas of the genome once considered "junk DNA." Though this genetic "dark matter" exists outside of our genes, scientists now appreciate that it helps control when and where our genes switch on and off. The precise coordination of genetic activity appears to be particularly crucial to brain development and function.

Through its research platform on the Google Cloud, Autism Speaks is making all of MSSNG's fully sequenced genomes directly available to researchers free of charge, along with analytic tools. In the coming weeks, the MSSNG team will be uploading an additional 2,000 fully sequenced autism genomes, bringing the total over 7,000.

Currently, more than 90 investigators at 40 academic and medical institutions are using the MSSNG database to advance autism research around the world.

Explore further: Largest-ever autism genome study finds most siblings have different autism-risk genes

More information: Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder, Nature Neuroscience (2017). DOI: 10.1038/nn.4524

Journal reference: Nature Neuroscience

Provided by: Autism Speaks

The largest-ever autism genome study, funded by Autism Speaks, reveals that the disorder's genetic underpinnings are even more complex than previously thought: Most siblings who have autism spectrum disorder (ASD) have different ...

A new study from Autism Speaks' MSSNG program expands understanding of autism's complex causes and may hold clues for the future development of targeted treatments. The report, appearing in npj Genomic Medicine is the largest-ever ...

Autism Speaks, the world's leading autism science and advocacy organization, today launched the web-based portal for its MSSNG database, making the resource available to researchers worldwide. The MSSNG portal enables qualified ...

A new study from investigators with the Autism Genome Project, the world's largest research project on identifying genes associated with risk for autism, has found that the comprehensive use of copy number variant (CNV) genetic ...

Autism Speaks, the world's largest autism science and advocacy organization, and BGI, the largest genomic organization in the world and a global leader in whole genome sequencing, jointly announce their partnership to create ...

Princeton University and Simons Foundation researchers have developed a machine-learning approach that for the first time analyzes the entire human genome to predict which genes may cause autism spectrum disorder, raising ...

Since the first case was documented in the United States in 1938, the causes of autism have remained elusive. Hundreds of genes, as well as environmental exposures, have been implicated in these brain disorders. Sex also ...

The newest study from the Autism Speaks MSSNG project - the world's largest autism genome sequencing program - identified an additional 18 gene variations that appear to increase the risk of autism.

Concrete links between the symptoms of autism and synaesthesia have been discovered and clarified for the first time, according to new research by psychologists at the University of Sussex.

A national research network led by UNC School of Medicine's Joseph Piven, MD, found that many toddlers diagnosed with autism at two years of age had a substantially greater amount of extra-axial cerebrospinal fluid (CSF) ...

Results of a small study of adults with autism at Johns Hopkins has added to evidence that their brains can learn to compensate for some language comprehension challenges that are a hallmark of the disorder in children.

In the February 2017 issue of Pediatrics, investigators representing the South Carolina Act Early Team report a five-fold increase in the number of children with autism spectrum disorder (ASD) eligible for early intensive ...

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World's largest autism genome database shines new light on many 'autisms' - Medical Xpress

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Genome editing: Pressing the ‘delete’ button on DNA – Science Daily

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Genome editing: Pressing the 'delete' button on DNA
Science Daily
CRISPR-Cas9 is a revolutionary technique for editing genomes and until recently, most studies employing it were aimed at silencing protein-coding genes, the best-studied part of our genome. However our genome consists of 99% of DNA that does not ...

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Longevity claims – Wikipedia

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Longevity claims are unsubstantiated cases of asserted human longevity. Those asserting lifespans of 110 years or more are referred to as supercentenarians. Many have either no official verification or are backed only by partial evidence. Cases where longevity has been fully verified, according to modern standards of longevity research, are reflected in an established list of supercentenarians based on the work of organizations such as the Gerontology Research Group (GRG) or the Guinness World Records. This list includes claims between 115 years and 130 years.

Prior to the 19th century, there was insufficient evidence either to demonstrate or to refute centenarian longevity.[1] Even today, no fixed theoretical limit to human longevity is apparent.[2] Studies[1] in the biodemography of human longevity indicate a late-life mortality deceleration law: that death rates level off at advanced ages to a late-life mortality plateau. This implies that there is no fixed upper limit to human longevity, or fixed maximum human lifespan.[3] Researchers in Denmark have found a way to determine when a person was born using radiocarbon dating done on the lens of the eye.[4]

In 1955, Guinness World Records began maintaining a list of the verified oldest people.[5] It developed into a list of all supercentenarians whose lifespan had been verified by at least three documents, in a standardized process, according to the norms of modern longevity research. Many unverified cases ("claims" or "traditions") have been controverted by reliable sources. Taking reliable demographic data into account, these unverified cases vary widely in their plausibility.

Despite demographic evidence of the known extremes of modern longevity, stories in otherwise reliable sources still surface regularly, stating that these extremes have been exceeded. Responsible, modern, scientific validation of human longevity requires investigation of records following an individual from birth to the present (or to death); purported longevity far outside the demonstrated records regularly fail such scrutiny.

Actuary Walter G. Bowerman stated that ill-founded longevity assertions originate mainly in remote, underdeveloped regions, among non-literate peoples, with only family testimony available as evidence.[7] This means that people living in areas of the world with historically more comprehensive resources for record-keeping have tended to hold more claims to longevity, regardless of whether or not individuals in other parts of the world have lived longer.

In the transitional period of record-keeping, records tend to exist for the wealthy and upper-middle classes, but are often spotty and nonexistent for the middle classes and the poor. In the United States, birth registration did not begin in Mississippi until 1912 and was not universal until 1933. Hence, in many longevity cases, no actual birth record exists. This type of case is classified by gerontologists as "partially validated".[citation needed]

Since some cases were recorded in a census or in other reliable sources, obtainable evidence may complete full verification.

In another type of case, the only records that exist are late-life documents. Because age inflation often occurs in adulthood (to avoid military service or to apply for a pension early), or because the government may have begun record-keeping during an individual's lifetime, cases unverified by proximate records exist. These unverified cases are less likely to be true (because the records are written later), but are still possible. Longevity narratives were not subjected to rigorous scrutiny until the work of William Thoms in 1873. Thoms proposed the 100th-birthday test: is there evidence to support an individual's claimed age at what would be their centenary birthday?[9][10] This test does not prove a person's age, but does winnow out typical pension-claim longevity exaggerations and spontaneous claims that a certain relative is over 150.

These are standardized lists of people whose lifespans remain unverified by proximate records, including both modern (Guinness-era) and historical cases. Claims missing either (or both) a date of birth/date of death are listed separately. All cases in which an individual's supercentenarian lifespan is not (yet) backed by records sufficient to the standards of modern longevity research are listed as unverified. They may be factually true, even though records do not exist (or have not yet been found), so such lists include these grey-area cases.

These living supercentenarian cases, in descending order of claimed age, with full birth and review dates, have been updated within the past two years, but have not had their claimed age validated by an independent body such as the Gerontology Research Group or Guinness World Records. Only claims over 115 years but under 130 years are included in the list.

This table contains supercentenarian claims with either a known death date or no confirmation for more than 2 years that they were still alive. Only claims of ages 115129 are included. They are listed in order of age as of the date of death or date last reported alive.

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Longevity claims - Wikipedia

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Future Human lifespan 140 years, 500 years, 1000 years or indefinite with aging damage repair and aging reversal – Next Big Future

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Speaking at the Aspen Abu Dhabi Ideas Forum, Dr Brad Perkins, chief medical officer, Human Longevity, said: Right now the most daunting and expensive human health problem that the world is facing is age related chronic disease. Our hypothesis at Human Longevity is that genomics and the technologies that support its application in medicine and drug discovery are going to be the next accelerant in extending a high performance human lifespan

Human Longevity Inc has been funded with over $220 million and was founded by Craig Venter, Peter Diamandis and Robert Hariri.

Dr. Brad Perkins and other anti-aging researchers at commercial companies made the more conservative for anti-aging researchers that within about 40 years human longevity (maximum lifespan) will reach 140 years. Current life expectancy is about 80 years but with some countries and states at about 90 years for women. The confirmed longest lived person reached 122 years of age.

Aubrey de Grey, a biomedical gerontologist based in Mountain View, California, US, and chief science officer of SENS Research Foundation, a California-based biomedical research charity that performs and funds laboratory research dedicated to combating the aging process, argued that the first person to live to 1,000 years is already probably alive today.

He further commented that fixing ageing is difficult, but not impossible and the only way in which people are going to stay alive a long time is by staying healthy a long time. His focus is on constantly repairing the known sources of aging damage before it becomes complicated disease.

Human Longevity, Inc. (HLI) is the genomics-based, technology-driven company creating the worlds largest and most comprehensive database of whole genome, phenotype and clinical data. HLI is developing and applying large scale computing and machine learning to make novel discoveries to revolutionize the practice of medicine. HLIs business also includes the HLI Health Nucleus, a genomic powered clinical research program which uses whole genome sequence analysis, advanced clinical imaging and innovative machine learning, along with curated personal health information, to deliver the most complete picture of individual health.

Peter Diamandis (Human Longevity co-founder) has argued at other conferences that technology should be able to enable humans to live as at least long as the longest lived large vertebrate. The Greenland shark has been to live 392 120 years old, resulting in a minimum age of 272 and a maximum of 512. That makes the Greenland shark the longest-lived vertebrate.

SOURCES - Trade Arabia, Human Longevity Inc, Peter Diamandis, George Church

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Future Human lifespan 140 years, 500 years, 1000 years or indefinite with aging damage repair and aging reversal - Next Big Future

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Monthly Archives: March 2017

Scientists store digital files in an unlikely place: DNA – Mashable

DNA Motors in Living Cells Start with MicroRNA Keys – Genetic Engineering & Biotechnology News (blog)

DNA Scan Uncovers 18 Genes Newly Associated With Autism – NBCNews.com

Plymouth DA releases DNA-generated sketch of man wanted for rape – Turn to 10

Principles of 3-D genome folding and gene expression studied across species – Phys.Org

Stream of surprises from the Atlantic cod genome – Science Daily

World’s largest autism genome database shines new light on many ‘autisms’ – Medical Xpress

Genome editing: Pressing the ‘delete’ button on DNA – Science Daily

Longevity claims – Wikipedia

Future Human lifespan 140 years, 500 years, 1000 years or indefinite with aging damage repair and aging reversal – Next Big Future

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