Daily Archives: March 27, 2017

Making eugenics acceptable again – BioEdge

Posted: March 27, 2017 at 4:57 am

Gene editing technology will inevitably lead to eugenics and thats a good thing, says Adam Cohen, the author of Imbeciles: The Supreme Court, American Eugenics, and the Sterilization of Carrie Buck.

Cohens book relates the tragic story of a young woman from Virginia who was forcibly sterilised. Her case went all the way to the US Supreme Court, which concluded, in the notorious words of Justice Oliver Wendell Holmes, Three generations ofimbecilesare enough. That case marked the highwater mark of the American eugenics movement. But Nazi atrocities almost completely discredited the idea.

However, writing in an op-ed for the Los Angeles Times, Cohen, like an increasing number of bioethicists, distinguishes between bad eugenics and good eugenics. The former is totalitarian and involuntary; the latter is individual and discretionary. He strongly supports the idea of embryo editing: This time around, eugenics could be a force for good.

... we should also recognize that there is a crucial difference between the old eugenics and the new. Rather than demonizing unfit people and working to sterilize them, the new eugenics regards their inherited disabilities as treatable medical conditions and seeks to help them have healthy children.

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Some paws for celebration: World’s first cloned cat turns 15 – Bryan-College Station Eagle

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Courtesy of Texas A&M

CC, the world's first cloned cat, recently turned 15 years old.

Posted: Thursday, March 23, 2017 3:49 pm

Some paws for celebration: Worlds first cloned cat turns 15 Eagle Staff Report The Eagle |

CC, who made history as the first cloned cat, recently turned 15 and according to her owner is still going strong.

CC -- short for Copy Cat -- lives with Duane Kraemer, a senior professor in the Reproduction Sciences Lab at Texas A&M's College of Veterinary Medicine and Biomedical Sciences. Kraemer cloned CC after 87 attempts, according to Texas A&M.

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Posted in Texas A&M, Local News, Zoology on Thursday, March 23, 2017 3:49 pm. | Tags: Duane Kraemer, Zoology, Cloning, Deer, Animal, Effort, Cat, Offspring

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Evolution Is Slower Than It Looks and Faster Than You Think – WIRED

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Slide: 1 / of 4. Caption: Skip Sterling/Quanta Magazine

Slide: 2 / of 4. Caption: Caption: Simon Ho, an evolutionary biologist at the University of Sydney, found that evolution takes place at varying rates.Courtesy of University of Sydney

Slide: 3 / of 4. Caption: Lucy Reading-Ikkanda/Quanta Magazine

Slide: 4 / of 4. Caption: Caption: Aris Katzourakis, a paleovirologist at the University of Oxford, dated a class of viruses to the era before the sea-to-land transition.Gillman & Soame

In the 1950s, the Finnish biologist Bjrn Kurtn noticed something unusual in the fossilized horses he was studying. When he compared the shapes of the bones of species separated by only a few generations, he could detect lots of small but significant changes. Horse species separated by millions of years, however, showed far fewer differences in their morphology. Subsequent studies over the next half century found similar effectsorganisms appeared to evolve more quickly when biologists tracked them over shorter timescales.

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Original storyreprinted with permission from Quanta Magazine, an editorially independent division of theSimons Foundation whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences

Then, in the mid-2000s, Simon Ho, an evolutionary biologist at the University of Sydney, encountered a similar phenomenon in the genomes he was analyzing. When he calculated how quickly DNA mutations accumulated in birds and primates over just a few thousand years, Ho found the genomes chock-full of small mutations. This indicated a briskly ticking evolutionary clock. But when he zoomed out and compared DNA sequences separated by millions of years, he found something very different. The evolutionary clock had slowed to a crawl.

Baffled by his results, Ho set to work trying to figure out what was going on. He stumbled upon Kurtns 1959 work and realized that the differences in rates of physical change Kurtn saw also appeared in genetic sequences.

His instincts as an evolutionary biologist told him that the mutation rates he was seeing in the short term were the correct ones. The genomes varied at only a few locations, and each change was as obvious as a splash of paint on a white wall.

But if more splashes of paint appear on a wall, they will gradually conceal some of the original color beneath new layers. Similarly, evolution and natural selection write over the initial mutations that appear over short timescales. Over millions of years, an A in the DNA may become a T, but in the intervening time it may be a C or a G for a while. Ho believes that this mutational saturation is a major cause of what he calls the time-dependent rate phenomenon.

Think of it like the stock market, he said. Look at the hourly or daily fluctuations of Standard & Poors 500 index, and it will appear wildly unstable, swinging this way and that. Zoom out, however, and the market appears much more stable as the daily shifts start to average out. In the same way, the forces of natural selection weed out the less advantageous and more deleterious mutations over time.

Hos discovery of the time-dependent rate phenomenon in the genome had major implications for biologists. It meant that many of the dates they used as bookmarks when reading lifes sagaeverything from the first split between eukaryotes and prokaryotes billions of years ago to the re-emergence of the Ebola virus in 2014could be wrong. When this work came out, everyone went Oh. Oh, dear, said Rob Lanfear, an evolutionary biologist at the Australian National University in Canberra.

The time-dependent rate phenomenon wasnt fully appreciated at first. For one thing, it is such a large and consequential concept that biologists needed time to wrap their heads around it. But theres a bigger stumbling block: The concept has been all but impossible to use. Biologists have not been able to quantify exactly how much they should change their estimates of when things happened over the course of evolutionary history. Without a concrete way to calculate the shifts in evolutionary rates over time, scientists couldnt compare dates.

Recently, Aris Katzourakis, a paleovirologist at the University of Oxford, has taken the time-dependent rate phenomenon and applied it to the evolution of viruses. In doing so, he has not only pushed back the origin of certain classes of retroviruses to around half a billion years agolong before the first animals moved from the seas to terra firmahe has also developed a mathematical model that can be used to account for the time-dependent rate phenomenon, providing biologists with much more accurate dates for evolutionary events.

Other scientists are excited by the prospect. Its like Einsteins theory of relativity, but for viruses, said Sebastin Duchne, a computational evolutionary biologist at the University of Melbourne. The time-dependent rate phenomenon says that the speed of an organisms evolution will depend on the time frame over which the observer is looking at it. And as with relativity, researchers can now calculate by how much.

Katzourakis has spent his career trying to pin down the origin of HIV and other so-called retroviruses, which are made out of single strings of RNA.

When he looked at the mutation rates of HIV, he found that it is among the fastest-evolving viruses ever studied. The speedy mutation rate makes sense: Double-stranded molecules like DNA have molecular proofreaders that can often correct errors made during replication, but HIV and other single-strand RNA viruses dont. Spelling errors occur on top of spelling errors.

Because of this, virologists can directly study only the recent history of viruses like this. Older samples have reached mutation saturation, with so many accumulated spelling errors that scientists cant account for them all. Taking the history of retroviruses back thousands or millions of years would require a different way to measure mutation rates.

Katzourakis turned to another technique. He searched for something akin to viral fossils inside the DNA of their hosts. Retroviruses often insert copies of their genetic material into their hosts cells. Most of the time, the information dies with the host. On rare occasions, however, a retrovirus hits the evolutionary jackpot and slips inside the genome of a sperm or egg cell. Nestled securely in its hosts DNA, the virus gets passed down through the generations.

Katzourakis used these viral relics to study the ancient origin of retroviruses. But when he did so, he got a big surprise. The rate of evolution of these retroviruses over long periods appeared to slow dramatically, nearly matching that of humans and other complex lifeorganisms that have proofreader machinery and thus should change at a much slower pace.

If the viruses were evolving much more slowly than scientists thought, it could imply that the viruses were much older than expected as well. After all, a slowly evolving virus will need more time to change by the same amount as a quickly evolving virus.

So he set out to find an accurate date for the origin of retroviruses. To do this, he turned to a group of the most ancient retroviruses, the so-called foamy viruses, which infect everything from monkeys to cows. This promiscuity enabled Katzourakis to calibrate his evolutionary clock to determine precisely when foamy viruses emerged. If two species shared a foamy-virus sequence, the virus must have infected their common ancestor, before the two species diverged.

It gives us a way to date events in deep evolutionary history thats independent of the sequences themselves, Katzourakis said.

Researchers in labs around the world had slowly pushed back the date of origin of foamy viruses to 100 million years ago. But Katzourakis found hints that the virus had infected reptiles, amphibians and even fish far earlier than 100 million years ago. To conclusively show that retroviruses were older than the accepted date of 100 million years, however, Katzourakis would need to date the virus itself.

He dived into Hos papers on the time-dependent rate phenomenon, hoping to figure out how to apply it to viruses. He also wanted to create a general model that would allow researchers to input the timescale they were observing and get back details about the organisms evolutionary rate.

Katzourakis and his student Pakorn Aiewsakun tried out four different ways to quantify how quickly the evolutionary rate appeared to change based on timescale. They found that a power law rate-decay model fit their data best and showed that evolutionary rates decrease exponentially as the timescale increases. A subsequent study of 396 different viruses revealed that the evolutionary rate slows at the same rate across almost all genome types and replication strategies. Existing evolutionary clocks, which fail to account for the time-dependent rate phenomenon, inaccurately date ancient viruses as being much younger than they really are.

Katzourakis and Aiewsakun then used the newly developed mathematical framework to recalculate the emergence of foamy viruses. Using their newly developed model, the scientists showed in a paper published in January that foamy viruses emerged somewhere between 460 and 550 million years ago. Independent work by the University of Arizona virologist Michael Worobey, published in Virus Evolution nearly simultaneously, also suggested that these viruses originated earlier than expected. These studies established the oldest date for any known group of viruses, although Katzourakis believes other viral groups may be even more ancient.

The findings have implications far beyond the earning of a trophy for the oldest virus. A convergence on the same date of origin for foamy viruses provides evidence that the time-dependent rate phenomenon isnt just a relic of statistics or the methods researchers use to date species. Katzourakiss model also gives researchers a tool to quantify the effects of the time-dependent rate phenomenon, which will prove key to understanding the factors that drive this phenomenon.

More broadly, the work by Katzourakis and Ho challenges the idea of a steadily ticking evolutionary clock. This changes the way we conceive of molecular evolution, Duchne said. It shows that there is no universal rate of evolution. Even the same organisms have rates that vary over time.

It also means that scientists may need to revise the dates of evolutionary events in the deep past, as they likely underestimated how long ago they truly happened, Katzourakis said. He is trying to understand whether the pruning of mutations by natural selection and mutational saturation is the sole contributor to the time-dependent rate phenomenon, or whether other factors play a role in how and why the phenomenon emerges.

Is it a limitation of our tools, or is there something that weve overlooked? If we can understand this process, it will give us some big evolutionary insights, Katzourakis said.

Original story reprinted with permission from Quanta Magazine, an editorially independent publication of the Simons Foundation whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences.

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A brewing debate on evolution theory picks up in India – The Hindu – The Hindu

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The Hindu
A brewing debate on evolution theory picks up in India - The Hindu
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Is 'niche construction' a revolutionary concept in evolutionary biology?

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The art of evolution: Matalie Deane’s works on display at Woodberry Forest School – The Daily Progress

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WOODBERRYMatalie R. Deanes picturesque paintings are as scenic as the beautiful, historic campus of Woodberry Forest Schoolthe location of her latest exhibit.

In one of her many paintings, Deane creates vibrant green leaves on towering trees that overlook the Woodberry Forest Schools chapel.

The Charlottesville native displayed about 45 pieces of her artwork during Fridays reception held inside the Baker Gallery, Walker Fine Arts Center.

Her vast selection of landscapes, seascapes, animals, historic buildings and plein air paintings will remain on display at the all-boy boarding high school until April 29. Deanes Progression exhibit also features images of her compilation of postcard paintings.

Deanes specialty is using watercolors on canvas.

I love painting water. I havent mastered it yet, but Im still working on it, said Deane, during her brief speech. I also enjoy plein air painting. I havent mastered that either, but I enjoy painting it. Its sort of like fishing, sharing things with individuals.

For Deane, the joy of painting started when she was a child.

When I got a box of crayons, I wouldnt let anybody have any of mine because I just loved my box of crayons so much, said Deane. As a kid, I just loved drawing and painting. If you gave me pen and paper, I was happy as a lark.

Woodberry art teacher Kelly Lonergan, who organizes the art exhibits, thanked the crowd for coming out to see the beautiful show.

He added that Deanes paintings are also for sale.

During the show, Deanes brother Dan Griffin played melodic tunes on his collection of accordions.

Deane said she started drawing something every day in 2014, working on design and colors. The following two years, Deane worked specifically on paintings and drawings, which became part of her evolution of her work in her Progression exhibit.

Deane received her bachelors degree in applied art from James Madison University in 1973. While, Deane works as a respiratory therapist, her passion for art still flourishes.

Deane has exhibited her works in a group and/or solo show since 2000, being judged in Maryland and Virginia, winning several awards.

For more information about purchasing a painting, contact Kelly Lonergan at 540/672-3900.

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The art of evolution: Matalie Deane's works on display at Woodberry Forest School - The Daily Progress

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The Evolution of Hamas – Foreign Affairs (subscription)

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Ayman Abu Odeh, who lives in Gaza, once had high hopes for Hamas. Like many Palestinians, the 50-year-old voted for the militant group and political party in the historic January 2006 election, out of protest more than ideology: Fatah, the secular faction that had dominated politics in the Palestinian territories for four decades, had become deeply corrupt, and a decade of negotiations with Israel had failed to produce a Palestinian state.

Life was comfortable enough before Hamas took control of Gaza in 2007 after a violent, six-day power struggle with Fatah. Abu Odeh used to own a cement mixer and made a good living in Gazas construction industrygood enough to build a three-story house in the northeastern city of Beit Hanoun. By the end of 2006, the cement mixer was gone, destroyed during an Israeli army incursion that followed Hamas capture of the soldier Gilad Shalit, who was released in 2011 in a prisoner exchange. Abu Odeh scraped out a living for a while as a laborer, but that work eventually dried up, and he now relies on charity. His two adult sons are both unemployed.

Abu Odehs house survived until the most recent war, in the summer of 2014. Then an Israeli shell demolished that, too. His family spent the following winter in an uninsulated trailer donated by the Moroccan governmentlike living in a freezer, he called it. His sisters family lives next door, in the two rooms of their home that survived the blast. They sleep on mattresses in the kitchen and worry that the gnarled structure above them will collapse. Electricity is out for most of the day; water comes by truck every third day. If you miss it, youre thirsty, he said.

Almost everyone in Gaza has a similar story. There was the woman at the Rafah border whose kidneys failed as she waited 15 months to cross into Egypt for medical treatment. Or the businessman who fired 80 percent of the staff at his factory because a

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Photos: The Evolution of Formula One Race Cars | WIRED – WIRED

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Slide: 1 / of 13. Caption: Caption: The Formula 1 World Drivers' Championships formally kicked off in 1950, but the front engined cars of the day would be unrecognizable to a modern viewer. Alfa Romeo dominated the inaugural season. This is the British Grand Prix, at Silverstone. Alamy

Slide: 2 / of 13. Caption: Caption: By the mid 1950s, regulations had started to limit engine size, though teams could use turbo or superchargers. In 1958 year, new rules meant every car had to burn standardgasoline fuel, rather than the alcohol-based fuels they'd used before. This is Stirling Moss in Rob Walker's Cooper at Goodwood. Getty Images

Slide: 3 / of 13. Caption: Caption: 1968 saw aerodynamic effects used in a big way as teams slapped hugewings on struts several feet high (seen here on a Rob Walker Racing TeamLotus inthe German Grand Prix). "They stole the idea from American Can-Am races," says motorsport historian Don Capps. It was also a particularly deadly year, claiming five drivers' lives---the bosses banned the high wings and introduced other safety rules. Grand Prix Photo/Getty Images

Slide: 4 / of 13. Caption: Caption: The 1970s marked the start of Formula 1 as fans know it today, and the technological innovations came thick and fast. Mario Andretti won the 1978 Formula 1 World Drivers Championship in this Lotus 79 which used 'ground effect' aerodynamics, effectively turning the underside of the car into the equivalent of the huge wing for gobs of downforce.Don Heiny/Getty Images

Slide: 5 / of 13. Caption: Caption: Renault's RS01 was the first modern racer to use a turbocharger, although regulations had allowed themfor over a decade. Initial reliability problems earned it the name the "yellow teapot" for the frequent clouds of white smoke. It proved itself in 1979, and other teams quickly adopted the turbo. Here it's competingin 1978 in Long Beach, California.Getty Images

Slide: 6 / of 13. Caption: Caption: John Watson's 1981 McLaren MP4/1 may not look revolutionary, but it was the first to be made as a single carbon-fiber composite monocoque, rather than a metal chassis. That made the car unbelievably light, stiff and strong. Early on, other teams worried about its crash safety, but it quickly become the standard way to build a racecar.Getty Images

Slide: 7 / of 13. Caption: Caption: In 1983 extreme ground effects had been completely banned, so Nelson Piquet's Brabham BMW BT52, here at the Italian Grand Prix, used heavily trimmed side pods, and a flat underside. By now the cars were all running very thirsty turbo engines, so pit stops were re-introducedfor refueling. They didn't last long, and were banned again in 1984.Getty Images

Slide: 8 / of 13. Caption: Caption: It was all change again in 1989. After several seasons of limiting boost pressure to try to rein in the insane power of F1 engines and make races safer and more entertaining, turbos were banned altogether. Naturally aspirated engines were back in, up to 3.5 liters, and 8 to 12 cylinders. This is legendary driver Ayrton Senna in his McLaren MP4/5 at the 1989 British Grand Prix.Getty Images

Slide: 9 / of 13. Caption: Caption: Formula 1 had gone a decade without a fatality when F1 great Ayrton Senna, shown here in the Williams FW16, died in a crash at the 1994 San Marino GP---after warning the banning of electronic driver's aids would prove dangerous. His death sparked another round of power restrictions and track adjustments.Mike Hewitt/Getty Images

Slide: 10 / of 13. Caption: Caption: By the late 2000s, the races were becoming boring to watch, thanks to evenly matched, reliable cars. So the bosses updated the regs yet again, reducing engine rev limits and allowing adjustable wings to change aerodynamics mid-race This Ferrari F150, shown testing at Spain's Ricardo Tormo Circuit, was one result.Paul Gilham/Getty Images

Slide: 11 / of 13. Caption: Caption: 2014 marked a shift towards smaller engines (turbocharged 1.6-liters with six cylinders), but heavier use of the Kinetic Energy Recovery System. During braking, KERS stores energy by spinning up a flywheel, then releases it during acceleration to boost performance. Infiniti Red Bull Racing shows its new RB10 during day one of winter testing in Jerez de la Frontera, Spain. Andrew Hone/Getty Images

Slide: 12 / of 13. Caption: Caption: For the 2017 season, the focus is back on overtaking, with an unwinding of many of the aerodynamic restrictions. F1's head honchos want cars to be faster through the corners, though viewers aren't convinced that'll make the races more exciting. The cars, like this one from reigning champions, Mercedes AMG Petronas Motorsport, are lower and sleeker, with much wider tires. Daimler

Slide: 13 / of 13. Caption: Caption: What comes next? More evolution. In late 2015, McLaren showcased one view of the future, with the MP4-X. It's electric, charged by the sun, and drivers steer it by thought. It's an extreme concept, but as the last six decades have demonstrated, Formula 1 tech doesn't stand still for long. McLaren

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UConn Bus Evolution: From Horses to Horsepower to Powering Up – Patch.com

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UConn Bus Evolution: From Horses to Horsepower to Powering Up
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STORRS, CT University of Connecticut officials last week showcased a new transit bus that is a virtual study hall on wheels. And it is a far cry from the old ag school horse and buggy. UConn transit buses have essentially evolved from those horses to ...

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Geneticist Wolf-Ekkehard Lnnig on Darwinism and Gregor Mendel’s Sleeping Beauty – Discovery Institute

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Gregor Mendel is, of course, the father of the science of genetics. In a new peer-reviewed paper, Mendels Paper on the Laws of Heredity (1866): Solving the Enigma of the Most Famous Sleeping Beauty in Science, geneticist Wolf-Ekkehard Lnnig asks why Mendels theory of heredity, developed in the 19th century, was initially rejected or ignored by many other scientists. Writing in the journal eLS, Dr. Lnnig concludes that its because at that time, the scientific community was completely enamored with Darwinian evolution and unwilling to consider ideas that did not fit with Darwins models of evolution and inheritance.

Darwinism cast a shadow over the study of heredity. As Lnnig puts it:

His [Mendels] analysis, discernment and exposition of the laws of heredity as well as his views on evolution diametrically defied and contradicted the ideas and convictions of Darwin and his followers. [T]he basic reason for the neglect of the laws of heredity was essentially this: To imply something like a static definition of the species by constant hereditary elements right into a momentous process vigorously favouring the Darwinian revolution (continuous evolution by natural selection without any teleology intimately combined with the inheritance of acquired characteristics, to underscore the latter, often forgotten point once more) was met although usually silently with skepticism, deliberate ignorance and strong opposition.

In other words, if you implied as Mendel did that species were static, you were doing that at a time when science vigorously favored Darwinism. That is why Mendels ideas met with skepticism and opposition. More:

And there is no doubt concerning Darwins overwhelming victory in the battle for the scientific minds in the nineteenth century, so much so that Mendels performance before the Natural History Society of Brnn was even met with scornful laughter.

Lnnig quotes Italian biologist Giuseppe Sermonti who concurs with this explanation: What really happened was that Mendel ruled out almost all the forces that Darwin had invoked to explain evolution.

Mendels theory of inheritance produces all-or-nothing traits. Lnnig explains that this conflicted with Darwins ideas about gradual evolution:

[P]erhaps even more important, Mendels discoveries cast doubt on another definitely decisive and essential part of Darwins theory: continuous evolution, for which Darwin had postulated infinitesimally small inherited variations, steps not greater than those separating fine varieties and insensibly fine steps, for natural selection can act only by taking advantage of slight successive variations; she can never take a leap, but must advance by the shortest and slowest steps.

According to Lnnig, [I]n Mendels view, endless evolution was neither probable for cultivated plants nor for species in the wild.

What does the phrase sleeping beauty refer to in Lnnigs title? In a science context, it means an idea or publication that lies dormant for decades, asleep, until being rediscovered and winning deserved acclaim and acceptance. From an article on this fascinating subject:

The most famous case of a sleeping beauty was that of Gregor Mendels seminal study on plant genetics that received widespread recognition 31 years after its publication. Sleeping beauties led to Nobel prizes (Herman Staudinger, Nobel in Chemistry 1953; Peyton Rous, Nobel in Chemistry 1966). They usually reflect premature discoveries that the scientific community was not ready to recognize when published. Some suppose that this has to do with most scientists tendency to adhere to their established paradigms.

The paradigm in this case was Darwins theory. In impeding the emergence of genetics, Darwinian evolution was a science stopper, and not for the first time.

Image: Sleeping Beauty, by Viktor Vasnetsov [Public domain], via Wikimedia Commons.

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The Rise of Retail Darwinism – PYMNTS.com

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Twenty-seven years ago marked the end of a shopping era in Baltimore. That was the year 1990 that retailer Hutzlers shut its doors forever after 132 years in the retail business.

The Grand Dame of retail in that town, my hometown, wasnt just a store: Hutzlers was a shopping experience. When its customers walked through its doors, they were treated to unbelievably personalized service and a vast but curated selection of exclusive merchandise. When they walked out, they held tightly to the brand cache that came from carrying a shopping bag emblazoned with the Hutzlers name.

As a longtime customer exclaimed when the store closed its doors, Hutzlers was like your mother; they took care of you. In 1990, everyone living in Baltimore, having grown up shopping at Hutzlers for just about every significant event in their lives, grieved like theyd just lost someone special.

I reflected on this story as I was preparing to speak to a group of retail executives last week since, like most middle-class kids growing up in Baltimore, shopping at Hutzlers was just what you did. It was where moms took their little girls to buy their Easter and Christmas finery and took their little boys to buy their Oxford shirts and navy blue blazers. Its shoe department selection and service rivaled any department store of its era.

I thought the Hutzlers story was an appropriate metaphor to spark a conversation about the state of retail today and what we might learn from those retail Grand Dames who exist no longer. Its a fitting case study to uncover important insights and reflect on the crisis that traditional retail is facing.

And debate an ending that may also be both similar and inevitable and perhaps even the right outcome for the many traditional retail brands who now struggle to reinvent themselves and survive.

Retails Golden Age

Hutzlers opened its doors for the first time in 1858 on the corner of Howard and Clay Streets in downtown Baltimore. One of the Big Four that occupied the same block in downtown Baltimore Stewarts, Hochschild Kohns, The Hecht Company and Hutzlers the department store then was a modern marvel of merchandise selection and presentation all under one roof. Women went shopping in dresses and hats, men in suits and ties. Shopping was an enjoyable, somewhat leisurely and very social, experience.

Hutzlers prided itself on being a retail innovator from the start.

Its stores had passenger elevators with elevator operators, gigantic display windows and a refund policy that gave customers back their cash if they returned items they no longer wanted even if those items werent bought from their store. They had a restaurant, the Tea Room, that served homemade Maryland classics, like Crab Imperial and Lady Baltimore Cake, that not only attracted shoppers but nearby businessmen for lunch.

Hutzlers was the first store to create a one-price policy that eliminated the common practice of haggling with sales associates and with it, the inequities over what its customers would pay for the same item.

They also curated merchandise that tapped into what consumers wanted to buy at that time. Hutzlers boasted, for example, that its fabric, button and lace department rivaled anything that existed outside of New York. What may seem quaint and anachronistic by todays standards, their approachresponded to a pretty important consumer trend in the late 19th and early part of the 20th centuries: the rise in popularity of the sewing machine and the desire of middle-class women to wear different clothes every day. By 1900, nearly all middle-class women had sewing rooms in their homes, using them to make clothes for themselves and their children. Hutzlers wanted those women as their customers.

During the Great Depression, Hutzlers also responded to the economic hard times upon which many of its customers had fallen. Hutzlers Downstairs, described as athrift store with Hutzlers standards, opened on the lower level of its downtown retail store in 1929. It carried a line of discounted merchandise, but not just any discounted merchandise merchandise that came with the Hutzlers imprimatur for style and quality.

That customer intimacy was the foundation upon which Hutzlers built its business and its financial strength for its first 90 years. It invested time, money and effort into building and securing those relationships. Someone, for example, was assigned to read the newspaper daily for notices of customer (or family member) deaths, births and engagements and then send personal handwritten notes, sometimes even accompanied by a small gift to those customers.

Hutzlers launched a free, same-day delivery service for its charge customers who wanted the convenience of charging and sending their bundles home. And for women who drove to its downtown retail location from the suburbs and parked in their parking garage, sales associates voluntarily carried their bundles so that women didnt have to juggle both their shopping bags and their kids on the way to the car.

Hutzlers focus on the customer could also be seen in its retail merchandising strategy.

Buyers worked with brands to source and then sell exclusive labels and clothing lines. It also launched new, popular and first-to-market products in their stores, always in limited supplies to engender immediacy and scarcity and always with the idea to use those products to bring people into the stores to buy those items and other things while there. In the 1970s, Hutzlers began staging a series of festivals in their downtown store, featuring items from a variety of European ports of call to keep women coming into the store to explore and buy those one-of-a-kind products.

Hutzlers sales were legendary and widely coveted because they were held only twice a year. Its annual Centennial Sale featured markdowns of existing merchandise. But it was the annual Occasion Extraordinaire sale that created the desire for people to stand in line for hours before the store opened to get their pick of that sale litter.

OE, as it was known, required a rigorous curation of merchandise on the part of Hutzlers buyers, well in advance of the sale. Items made available for the sale had to be approved by management first and offered at a minimum of 20 percent off. Often these products were sourced from other parts of the world and specified only for this sale. One of the privileges of being a Hutzlers charge customer was access to this sale two days before it was open to the public.

Life was very good for the Hutzlers family and its eponymic department store.

Until, suddenly, it wasnt. At all.

Hutzlers saw the same data that everyone else did in the 1950s and 60s and responded to the economic reality of its shoppers moving to the suburbs. It expanded its footprint accordingly, opening its first suburban location 80 years later in the affluent suburb of Towson, Maryland, in 1952. Between 1952 and 1981, Hutzlers opened nine other suburban locations.

It also kept investing in its downtown flagship store, given its significant contribution to the bottom line at the time. It was also an asset that the Hutzlers family valued immensely.

And it was also a decision that would ultimately set the stage for the death spiral that would deliver Hutzlers demise.

The late 1960s and 1970s was a time of great social and economic upheaval in Baltimore. Civil unrest drove those who once lived and shopped downtown to the suburbs. Over a40-year period, from 1950 to 1990, Baltimore Citys population decreased by nearly 214,000 people with 119,000 residents leaving the city in the decade between 1970 and 1980. Another 51,000 left between 1980 and 1990. Those who used to shop downtown also stopped going.

At the same time, the Vietnam War created a wave of activism against The Establishment. Young people turned their backs on, among other things, the retail stores where their establishment parents shopped.

The two-year recession that started in 1973 saw the post-WWII economic boom come to a screeching halt. The rise of the two-income family during that period introduced time pressures that didnt exist before. Women entering the workforce had no time for leisurely shopping trips to Hutzlers downtown store or even any of its suburban retail locations.

At the same time, discount department stores came marching full-force into Baltimores suburbs. Caldor, Two Guys, Korvettes, Epsteins, Luskins to name but a few appealed to this cash-strapped, time-starved shopper under the rubric of more value for less money. Those stores were a short, easy drive away with free parking in vast parking lots.

Hutzlers, not unlike its other Big Four compadres, began to see its sales suffer because of these shifts and saw it happen most dramatically at its downtown flagship store, which once drove the bulk of its revenue. In 1968, the downtown store delivered $22 million in annual sales. Nine years later, in 1977, those sales had been gutted by 50 percent.

But despite the lack of customers and the lack of sales there, Hutzlers doubled down on investing in its downtown location. While three of its Big Four competitorscut back and ultimately closed their downtown operations in the late 1970s and early 1980s, Hutzlers invested millions in the renovation of its flagship store one they affectionally called the mothership. That renovation was completed in 1985 in the hopes of bringing its suburban customers back downtown as part of the citys bigger plans for urban renewal and redevelopment.

Five years earlier, in 1980, Hutzlers opened a new store near the citys brand new, tony Inner Harbor in an effort to appeal to a female business customer shopping on her lunch break. A smaller format store, it featured luggage and work-appropriate clothing lines for men and women.

Neither delivered the impact that the Hutzlers team had expected.

The limited selection of merchandise combined with competition from the newer boutique shops in the Inner Harbor area meant the store failed to grab the attention of that female shopper on her lunchbreak. And the Palace Store was stocked with merchandise at price points that might have appealed to a suburban shopper thirty years before, but was well out of the reach of the urban dweller with far less money to spend.

Keeping the downtown store afloat in the midst of the macro social and economic issues that retailers were facing in the late 1960s through the 1980s drained the profits made in Hutzlers other suburban stores. That meant less cash all around with which to buy the more exclusive merchandise that the loyal Hutzlers shopperwas accustomed to buying.

Hutzlers had no choice but to change its merchandise mix to reflect both its cash-strapped reality and, it thought, the shoppers demand for more reasonably priced goods. But that only confused its loyal customer base, who no longer knew what Hutzlers stood for, while failing to attract new customers who had already established other store preferences.

Hutzlers was forced to close stores and sell off real estate assets, notably the land upon which the parking garage adjacent to its Towson store was located. The Towson store was the last Hutzlers store to close in January of 1990.

Ironically, perhaps, that location is home to a mega Barnes &Noble that will close in May of this year. None of the other stores referenced in this piece exist anymore none of the discounters that challenged Hutzlers and none of the department store rivals who tried to,either.

The one exception is the Hecht Company, one of the Big Four that was acquired by The May Company in 1959. The May Company, with its scale, was in a better position than the other family-owned and operated businesses to put substantial capital into the Hecht Company franchise in Baltimore, even propping up its downtown location as a lower-priced competitor to Hutzlers over the years. The May Company merged with Federated Department Stores in 2005, and, in 2006, the last remaining Hecht Company stores in Baltimore were converted to Macys.

And we all know Macys ongoing retail struggles.

There is a lot we can learn about retail today from the Hutzlers story and why traditional retail stands where it does right now.

The shift from urban shopping to the suburbs is not unlike the shift from physical to digital.

Hutzlers made a critical mistake when trying to navigate that shift: It assumed that people would always prefer shopping downtown. Even until the end, the retailer was convinced that they could always lure shoppers back to the place that they loved, but found too late that different customers with different preferences didnt value the same things. Undaunted, Hutzlers continued to invest in that physical asset even at the expense of its other locations until it was forced to sell off all of its assets to pay the bills.

The shift in consumer preferences brought about by the changing economic and social mores is no different than the shift being driven today by the changing preferences of all consumers who value a different retail shopping experience and define loyalty very differently.

Millennials dont want to shop at the stores that their parents shop any more than we wanted to at their age, unless its Amazon where they even buy their clothes. Their litmus test isnt what name brand is on the masthead, but whether a store can offer them value for the money and the products they and not their parents want to buy. Hutzlers banked on the fact that their brand alone was enough to keep customers coming and once they came, theyd find what they wanted. In the end, it wasnt even nearly enough.

The allure of the discounter at the expense of Hutzlers sales is no different than the allure of the discount today.

Retailers have trained the customer that there will always be a sale. So, like good students, consumers wait until they get a promo code thats better than the last promo code they were offered two days before. The days of anticipating a sale and the execution of strategies that advocate the exclusivity and scarcity of merchandise at full price as a lure for shoppers is long gone.

The allure of the experience of shopping at Hutzlers is no different than the experience that everyone seeks today when they shop.

Serendipity was the experience that Hutzlers created for shoppers when times were good the anticipation of not knowing what that shopper might find until she walked through the door and started to navigatethe store. More than its other Big Four department store companions, Hutzlers built its reputation on outstanding merchandising and curation and the joy of finding something special. It was what made shopping fun and the experience consistently enjoyable. When its financial condition kept it from delivering that experience, consumers no longer had a reason to visit. Todays traditional retailers dont offer their shoppers that serendipity either. Supply chains and business models force financial constraints that, in turn, dont offer consumers the merchandise variety and frequency and uniqueness, which should give them incentive to shop their stores.

The problems are real, and the solutions are tough.

As a result, some retailers live in denial, clinging to the 92 percent of sales still happening in physical retail fantasy, while at the same time watching shopping foot traffic plummet dramatically over the last seven years.

Some want to blame Amazon for commoditizing retail rather than face the reality that when consumers arent offered a choice in physical locations, its just easy to buy from Amazon or another online retailer. And that brands, knowing this, adapt their own retailing strategies accordingly, reserving their best and most complete selection for the channels where they get traffic via their own physical or virtual stores or marketplaces where there is a steady and reliable stream of eyeballs.

Some just fiddle while Rome burns, implementing new technologies in an effort to make paying for stuff easier in their stores, when their real problem is getting consumers interested enough to buy from them in the first place.

But none of them, at least not publicly, will admit that maybe the best thing to do is to milk the asset for what its worth while the getting is good, and acknowledge that, like Hutzlers, nothing lasts forever. Sell off valuable assets, like Sears has done with Craftsman, or real estate, like Macys is doing.

And recognize that they cant reinvent themselves so perhaps they should stop trying.

After all, businesses, like people, die. Only 13 companies on the Fortune 500 list are more than 150 years old: banks, insurance companies, consumer products companies and one retailer Macys. And nine out of every 10 companies on the Fortune 500 list in 1955 when it was first launched have disappeared.

Thats not all bad. It illustrates the vitality of business and the power of innovation. It shows what happens when we make room for strong, bold ideas that scale and usher in new paradigms. It demonstrates the ability ofthose strong companies to respond to the shifts in the markets that they grew up with instead of the struggle that comes when growing into those markets from a totally different starting point.

Especially when that reinvention happens too late in the process to change the outcome.

In his book about the history of Hutzlers,Michael Lisicky recounts astory of family heir, David Hutzler, who received a package delivered to his office by a mailman shortly before the Towson store closed. The mailman was said to have remarked to Hutzler, after he had expressed his profound sadness to him over the course that the family business had taken, but you did pretty good for 135 years.

Maybe thats not such a bad perspective to have.

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The Rise of Retail Darwinism - PYMNTS.com

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