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Daily Archives: March 5, 2017
The Best Cryptocurrencies of 2017 | Top Ten Reviews
Posted: March 5, 2017 at 3:53 pm
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Cryptocurrencies are a form of money specifically designed to take advantage of the architecture of the internet. Instead of relying on a standard financial institution to guarantee and verify transactions, cryptocurrency transactions are checked, or "confirmed," by the computers of the users on the currency's network. The computers that verify the transactions usually receive a small amount of currency as a reward. The process of receiving rewards in exchange for verifying transactions is called "mining," and it is the main way that new currency is produced. Mining works differently for different currencies.
Because cryptocurrencies are completely digital, they can be used in ways that ordinary currencies can't; primarily, they are used like the digital equivalent of cash. Unlike credit or debit cards that are issued by banks, you don't need an account or good credit to use cryptocurrencies, yet you can use them to buy goods and services from an increasingly diverse selection of retailers and individuals. For instance, Overstock.com and Newegg.com accept Bitcoin as payment. There is typically a very small fee for almost every transaction, but it's typically much lower than credit card processing fees and interest, and the fees support the network.
Another common practice is to use small amounts of cryptocurrencies to "tip" people on IRC chat, social media and blogs. For instance, independent developers have designed "tipbots" for Reddit, Twitter and other social platforms that allow you to send money to a friend or anybody you feel has made a tip-worthy comment. The amounts you can send can be very small, like fractions of a penny, or quite substantial.
Cryptocurrencies can be converted at lightning speed or used to represent things that aren't normally currencies, such as domain names or consumer goods. Depending on the currency being used, it is also possible to anonymize transactions, turning cryptocurrencies into a form of discreet online cash. Most importantly, cryptocurrencies can be sent anywhere in the world, almost instantaneously, enabling users to deal directly with each other over the internet, rather than through a third-party financial institution, paying currency conversion fees or waiting for a bank to release funds.
While they are not entirely immune from fraud or theft, they are generally safe to use and difficult for malicious hackers to steal. As with cash, you'll need to take some precautions to protect your coins. For one, you'll want to encrypt your wallet with a very strong password and take regular backups, and it's a good idea to keep the backup and a written copy of your password in a remote location. Never give your password or wallet to somebody you don't trust, and keep the wallet software up to date at all times. Just like cash, if it's lost, damaged or stolen, you can't recover the funds. It's also a good idea to keep the bulk of your money offline, either in a "paper" wallet or on a storage device that may be disconnected from the internet when it's not in use. Three of the top cryptocurrencies are Bitcoin, Darkcoin and Nxt.
Cryptocurrencies use a number of different algorithms and are traded in different ways. Here are the main characteristics that you should consider.
Market Capitalization and Daily Trading Volume A cryptocurrency's market capitalization is the total worth of all coins currently in circulation. A high market capitalization can indicate a high value per coin or simply a lot of available coins. Perhaps more important than market capitalization is daily trading volume: the value of the coins that exchange hands every day. A high daily trading volume relative to the market capitalization indicates a healthy economy with many transactions.
Verification Method One of the major differences between cryptocurrencies is their verification method. The oldest and most common method is called proof of work. To gain the right to verify a transaction, a computer has to expend time and energy solving a difficult math problem. The trouble with this method is that it requires a massive amount of energy to operate. Proof-of-stake systems attempt to solve this problem by letting the users with the largest share of the currency verify the transactions. These systems require less processing power to operate and claim faster transaction speeds, but concern over security means that few coins use an entirely proof-of-stake-based system.
Retailer Acceptance A cryptocurrency isn't much use if you can't buy anything with it. That's why it's important to know who accepts a currency before you invest in it. A few cryptocurrencies are widely accepted, even boasting partnerships with major retailers. Most, however, have more limited acceptance, and some can only be exchanged for other cryptocurrencies. Some coins simply aren't designed to be exchanged for goods and are built for other purposes.
Cryptocurrencies are an exciting new development in the world of finance. No one is quite sure yet where the technology will lead, but the fact remains that these new currencies offer possibilities that traditional cash can't.
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Cryptocurrency Will Cripple Governments – lfb.org
Posted: at 3:53 pm
Reality is perceived in models. Or maps, if you will. But the map, observed Alfred Korzybski, is never the territory. Meaning, the best we can do is create effective models that work well with reality yet, with full knowledge that it will never represent the full scope of reality. And will, therefore, need uncompromisable adaptability.
Some maps, then, are more effective than others. And it usually goes that the more mainstream the model, the less effective it works in helping you navigate through the tangled webs of reality.
Looking at politics in terms of partisanship, for example, is a very poor representation of reality. It fails to give you the big picture. It fails to represent politics as politics really works which is, in reality, transcendent of partisanship.
Looking at politics, rather, in terms of centralization vs. decentralization is not perfect, but it is, we think, a much better representation than the latter.
Politicians are generally centralists (there are exceptions but very few). They see a perpetual need for more privileged (AKA powerful, but little-to-no skin in the game) fixers (see:pseudo-experts) to give the plebs what they need. Whether the plebs want it, need it, or ask for it is, of course, entirely irrelevant.
On the other hand, those who see this aforementioned mentality as an enormous and fundamental problem are, generally, decentralists.
One decentralist, Paul Rosenberg of the Freemans Perspective blog, outlines why stacking on more centralization to our over-centralized Jenga Economy is counterproductive in his latest piece:
#1: Centralization disrupts price discovery: Disrupting price discovery that sounds very economic.
What it means is this: Whenever headquarters decides to meddle in business transactions, large sections of the marketplace are thrown out of order. The biggest offenders in this area were the 20th centurys socialist states. Im not sure precisely how many people died (mainly of starvation) from their economic experiments, but the number is in the range of 100 million.
#2: Centralization robs the people: Centralization creates a group of people who eat (and generally grow rich) at the expense of everyone else. Every dollar that goes to politicians for their very fine offices and cars and travel budgets and everything else is money that is stolen from you and your neighbors.
#3: Central bosses enforce arbitrarily in order to gain artificial legitimacy: Did you ever notice that politicians are forever creating new fears? And why? Well, because solving those fears (even if theyre mostly imaginary, as most are) makes them seem necessary.
From this we get any number of disasters, especially wars. Have you noticed that presidents become far more popular when they wage a war? Fear sells, and war is a tremendous spectacle. And it makes the centralizers look necessary. (Too bad about all those dead guys.)
#4: Centralization is limiting.Centralized power solving our fears requires an ever-increasing number of laws, and each law is a restriction of some kind. Pretty soon, you cant do half the things you could a couple of decades before. Theres a law for every problem and a department to solve it. Address it yourself and youre likely to get hurt.
So, to keep us safe from our professionally cultivated fears, your kid cant run a lemonade stand without a license, your older aunt cant watch the neighbor kids, and God help you if you try to give a lost child a ride home.
#5: Centralization kills cooperation: There are rules for everything. So, you can no longer cooperate with your neighbor because you enjoy it. No you cooperate because its commanded by law and youll be punished if you dont.
Have you noticed people yearning for the old days and talking about small, rustic communities where the people still look out for each other? Well, theyre right to yearn for that, because its a very healthy way to live. And its centralization that stole it from us.
#6: Centralization robs you of self-worth: Following on from #5 above: What happens inside you when you help people because you, by yourself, give a damn? I think we all know the answer: You become a better, happier, and more beneficial person. You know you did a good thing. And then you feel good about yourself.
Every time you do the right thing because its mandated by law, you are being robbed of self-worth and self-improvement. And your friends and neighbors are robbed of your improved state.
Decentralization wont happen if the decentralists wait for full permission from the centralizers.
Thats just the truth.
Fortunately, we live in an era where decentralization has a fighting chance because it, ultimately, doesnt need permission. Permissionless innovation truly does have the ability to creatively destroy (and, at the same time, create anew), the forces which hanker for unlimited control and resources to themselves and their cabal.
(Take, for example, this piece in Reuters on how Venezuelans are bypassing backwards currency controls with bitcoin.)
This is precisely why weve spent much time the past year digging deep into the cryptocurrency space. Cryptocurrencies have incredible potential to compete economically with the worlds governments.
Maybe not subvert them completely, as some claim (such as, for example, the author of todays featured article below) but they can certainly, at the very least, whip them into shape.
Today, to explain the broad view, we invite Rick Falkvinge to the show to share his perspective: Cryptocurrency, according to him, will cripple todays centralizing forces. And, unfortunately for them, they wont see it coming.
Read on.
Cryptocurrency will cripple governmental ability to collect taxes, and they wont see it coming. When its already happened, expect major changes to take place in how society is organized on a large scale but also expect governments to act in desperation to retain control.
As bitcoin launched in 2009, most early adopters saw its disruptive potential. While bitcoin has stalled for some time approaching a valid use of the term stagnation, cryptocurrency in a larger context is still just as disruptive. In 2011, I stated that bitcoin (cryptocurrency) will do to banks what email did to the postal services. This is not just true, but it will be even more brutal to governments, and by extension, governmental services.
Now, governments love anything that smells like innovation, because it means jobs, this magic word that smells of magic unicorns to anybody in government. Therefore, people who like innovation are nurturing this bitcoin thing, this cryptocurrency thing, this ethereum thing (as if governments made a difference, but still).
Lots of startups in tip-of-the-spear financial technology means that their government may get a head start over other governments. They have no idea that cryptocurrency will radically scale back the power of government, not just their own one, but also all those other governments over which it seeks a competitive edge.
Individual people in government can also love bitcoin because it gives them something to do. More specifically, it gives them something to regulate. Fortunately, other people in government see that this gives them something to do, which is to hold those government regulators with an overdeveloped sense of order somewhat in check.
Youll hear no shortage of wannabe regulators saying that bitcoin is bad because its being used in crime and contraband trade!, to which I usually respond, well, bitcoin is a currency, so I mean you put it in relation to the US Dollar, which then is not used in crime and contraband trade, is this the argument youre using to support your position?, at which point the discussion generally changes topic.
This completely disregards the observation that bitcoin and cryptocurrency were designed to not submit to regulation in the first place. Well, at least not governmental regulation. It is heavily regulated but by its source code, and by its source code alone.
The reason this will cripple todays governments todays idea of what a government is and does is because todays economy is built on one layer doing actual work and three layers of abstraction on top.
At the first and bottom layer of our economy are the individual people doing all the actual work.
The second layer on top of the first is the abstraction we call corporations, which is a way to organize our economy and optimize transaction costs.
The third layer on top of the second would be banks, which handle money for corporations and individual people in a middleman gatekeeper position.
Finally, the fourth layer is the government, which takes advantage of the banks gatekeeper position to siphon off taxes from money flows in order to fund itself and governmental services. In other words, layer four completely depends on layer three for its operations or at least for the relative simplicity of funding its operations.
Now, what bitcoin and cryptocurrency do is make away with the banks cutting them out of the loop entirely, making them redundant, obsolete, dinosaurified. This resulting absence of anything where banks used to be creates an air gap between the functional part of the economy people and corporations and governments who want funding.
The way governments want to tap all money flows in order to fund itself is not entirely unlike how the surveillance agencies want to tap all information flows in order to have an information advantage.
In this way, the deployment of cryptocurrency is to tax collection what deployment of end-to-end encryption is to mass surveillance. The government can no longer reach into money flows and grab what it wants, but will be dependent on people actively sending it money. The government cant point a gun at a computer and have it give up its money; you can only make a computer operator feel very sorry for not voluntarily producing the keys to that money. So the government is no longer able to collect taxes without the consent even if coerced and forced consent of the people being thus collected.
The deployment of cryptocurrency is to tax collection what deployment of end-to-end encryption is to mass surveillance.
Governments, and individual people in government, have no idea about this bigger picture. Theyre far to wrapped up in things-as-usual to notice. They wont see it coming until its already happened.
When this happens, there will be no shortage of people in government who suddenly want to regulate cryptocurrency only to find out it will be as effective as regulating gravity. When this happens, government as we know it will be redefined from a coercive Colossus able to take what it wants and do what it wants into a construct that actually depends on people wanting to fund it. This will be a very interesting time to live in. While todays governments will see themselves as getting crippled, I suspect most citizens will regard it as unquestionably healthy that governments will actually begin to depend on the approval of the people at large.
Were just beginning to see the changes to society that the Internet brings. This is one of them.
(Note: I write cryptocurrency and not bitcoin on purpose here, just as Id prefer proclaiming the success of social media over the success of Myspace.)
[Ed. note: This article originally appeared on Ricks blog at this link.]
Regards,
Richard Falkvinge Head of Privacy, Private Internet Access
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Cryptocurrency: Major Coins Are Booming – Eastern Daily News
Posted: at 3:53 pm
Back in 2009 when the first Cryptocurrency, Bitcoin, was announced, no one thought this industry would reach these heights. The truth is, the Cryptocurrency community has grown a lot over the past eight years. After Bitcoin was released many developers have come out with new digital currencies. Right now there are hundreds, if not thousands of them, out there. Cryptocurrency users have also increased almost exponentially. At the moment, many industries are accepting digital currencies as forms of payment. Merchants and retailers have also not been left behind, they have realized that Cryptocurrencies can be viable alternatives to fiat currencies.
According to Coin Market Cap, Cryptocurrency Market Capitalization has reached an all-time high of more than US $24 billion. The main drivers to this all-time high milestone are the major coins right now namely Bitcoin and Ethereum. Dashhas also been causing waves lately, as it has gained more than $70 million this week alone, therefore rising to number three among all Cryptocurrencies. Cryptocurrency users, since the beginning of the year, have been on a spending spree and these three coins have benefited a lot from this because they have attracted adoption based on different use cases.
Bitcoin by far dominates the Cryptocurrency Market Capitalization, its market cap is $20,682,061,514 and thats 84.7% of the entire Cryptocurrency market cap. Bitcoin is now viewed by many as an addition to investment portfolios, its uniqueness makes it desirable to many investors since it reduces total risks while at the same time it has a potential to increase gains. At some time this week, Bitcoin surpassedgold parity and this proves how much it has been growing steadily, especially in 2017. This week, major investors have been talking about their optimismon the approval of the first US Bitcoin exchange-traded fund (ETF) by the Securities and Exchange Commission (SEC). This is definitely very good news to Bitcoin users, especially those based in the US. Investors are really waiting on the SEC to give its final decision on this matter because, if approved, Bitcoins price is expected to increase.
Moving on to Ethereum, this coin was released in 2015, so its barely two years old, but it has risen to number two among all other Cryptocurrencies. It has grown so fast both in terms of price and value. Its pricehas almost doubled in the past two weeks i.e. up from around $10 to $19. Its market cap has also risen to more than $1.7 billion which is an all-time high. Ethereum is the second coin to reach the $1 billion mark after Bitcoin. The Ethereum community has always spoken of a flipping the point where its market cap surpasses Bitcoins. These are some bold words to say especially when you compare the numbers, but they argue that what Bitcoin can do, Ethereum can do better. I dont see how the two can be compared because they use different ideologies. Ethereum is concerned with a wider range not just money.
For details on Dash, and the reasons behind its rise read this article. Investingin Cryptocurrency, especially the major coins is something worth a try. Its clear 2017 promises big returns.
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Cryptocurrency: Major Coins Are Booming - Eastern Daily News
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Bitcoin Scam Site Warning Coinomia – The Merkle
Posted: at 3:52 pm
It has been a while since we last looked at bitcoin scam sites, even though they are even more common than ever before. Coinomia is another cloud mining Ponzi Scheme that aims to defraud users. The company makes some very bold claims which are not backed by any solid or credible evidence by any means. Avoid this company at all times and invest wisely.
A lot of companies who claim to be active in the world of bitcoin and cryptocurrency require a lot of budget to set up mining operations. That being said, it would appear there are so many companies active in the world of cloud mining bitcoin, even though there are very few legitimate offerings available. Coinomia is definitely not a legitimate mining company, as they provide no evidence whatsoever.
When one opens the Coinomia website, it becomes evident the company is trying to trick as many users into investing as possible. The company also claims to be mining since 2014, yet there is no proof of this claim being true by any means. It is possible this may have taken place under a different name, although it is unclear which company that would have been. Rest assured this is the first sign of Coinomia being a scam.
Users who sign up with Coinomia will get 3TH/s for signing up. Users who prefer to mine Ethereum will receive 0.58 MH/s of hashing power. It is rather unusual to see companies give away such large amounts of hashing power in exchange for US$100, as it requires a fair amount of hardware to provide these speeds. Then again, Coinomia has no mining hardware in the first place, and all of this free mining power only represents an update in the database.
To top it all off, the mining plan comes with 8% referral commission. The goal of Coinomia is to get users to invite as many people as possible to make sure the people running this cloud mining scheme can fill their pockets. More expensive plans are also available, ranging from US$1,000 to US$10,000. It is rather odd to see these prices not listed in BTC or ETH value, but then again, this is a scam site after all. More expensive plans result in higher referral commissions, which is absolutely bogus.
What is even more troublesome is how Coinomia positions itself as being a mining application, rather than a cloud mining company. They also claim any device or gadget can be used to mine cryptocurrency and earn these returns. That is a very strange business model, considering the company claims to have ASIC chips and mining equipment located in data centers around the world. If that is the case, why do users need to download this software? Very strange indeed.
Not much information can be found about the company itself either. Although Coinomia Technologies LTD has an office address listed on the website, it is doubtful that location houses any office related to this business. Moreover, there is no company registration number, although the team would probably be able to present a company number when requested. All it takes is a bit of cash and the paper is issued automatically. All things considered, it is best to steer away from Coinomia and not lose your money.
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Average Bitcoin Transaction Fee Has Exceeded $1 The Merkle – The Merkle
Posted: at 3:52 pm
The Bitcoin network has been congested for quite some time now, blocks have been full and the debate has been at a stalemate. As Bitcoins adoptions is rising, along with increased coverage in the media about the price breaking all time highs, the amount of transactions has been on the rise. This has contributed to an increase in the average fee paid as users need to pay more and more in order to get their transactions to confirm in a reasonable amount of time.
Developers and users have been long aware of the problem that faced Bitcoin when the amount of transactions exceeded the available space in the blocks. The mining fees will increase because more transactions are competing for the miners hash power.
While this is beneficial to miners, users have to pay higher transactions fees. That fee has been slowly rising until now, it finally has reached the levelof an old school financial institution. Checkout this chart that shows the rise of Bitcoin transaction fees over the past 2 months:
The good news is that SegWit activation is progressing alongas the current amount of nodes signaling it is hovering right around 30%. Furthermore, as the development of the Lightning network and other similar solutions progresses we may be able to fit much more transactions in the same amount of space.
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Average Bitcoin Transaction Fee Has Exceeded $1 The Merkle - The Merkle
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Top 5 Safe Bitcoin Wallets – The Merkle
Posted: at 3:52 pm
The only way to properly store your bitcoin wealth is by using a safe wallet solution. It is hard to quantify what makes one wallet safer than the next, as users have their individual preferences and needs in this regard. However, there are some wallet solutions out there that take keeping funds safe to a whole new level.
On the software side of things, there are quite a few different bitcoin wallets to choose from. However, one of the primary wallets people use in this regard is Multibit, due to it being lightweight and easy to integrate with hardware solutions. Although Multibits interface looks rather traditional, the wallet receives regular updates to improve security. A convenient and secure software solution to store funds, that much is certain.
Any bitcoin wallet provider providing cold storage and multi-signature support deserves to be on the list of top secure bitcoin wallets. Armory checks the right boxes in this regard, as the software stores private keys in an offline computer. This makes it impossible to steal bitcoins, unless someone has access to the physical location of the computer. No one knows where this location may be, though. Moreover, giving users the chance to set up cold storage solutions themselves is a big bonus.
On the mobile front, there is a lot of competition for the crown of being the most secure wallet solutions available today. Mycelium has gotten a lot of support in this regard, as they are considered to be a must-have secure bitcoin storage application. Their HD wallet support, as well as an option to delete the private key from the device and integrate watch only accounts make Mycelium one of the top secure mobile bitcoin wallets.
Hardware bitcoin wallets have become quite popular over the past few years. That is only normal, as storing bitcoin in a secure manner becomes more important than ever. Hardware wallets are designed to facilitate secure funds storage, with quite a few companies launching their products in recent years. KeepKey is one of the top solutions in this regard, as the device requires users to manually approve every transaction. Moreover the device has PIN protection, adding an extra layer of security.
The Ledger line of hardware bitcoin wallets can not be ignored. The company prides itself on making affordable yet secure bitcoin wallet solutions. There is no reason to pay hundreds of dollars for a device when the same goal can be achieved with a device costing a fraction of the price. Dont let the cheap price fool you, though, as every one of Ledgers devices is more than capable of keeping your wealth safe.
All of Ledgers wallets come in the form of a USB-size, although there are minor differences between each type. The Ledger Nano S is by far the most popular hardware wallet, as it is capable of storing both Bitcoin and Ethereum. Moreover, users can complete wallet actions through the display on the device or by using the browser plugins. An affordable, robust, and secure line of products, that much is certain.
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This Decatur company is taking humans to space – The Decatur Daily
Posted: at 3:51 pm
United Launch Alliance this year will begin assembling the Atlas V rocket that will boost two astronauts to the International Space Station, a spokeswoman said last week.
The project, to be handled at ULA's Decatur manufacturing plant, is part of NASAs commercial crew program, a plan to end American reliance on Russia to ferry astronauts to and from the space station 249 miles above the Earth. Since the retirement of the space shuttle in 2011, all astronauts have been delivered via Russian Soyuz spacecraft.
We are bridging history as we prepare to launch American astronauts again, ULA spokeswoman Lyn Chassagne said. John Glenn became the first U.S. astronaut to orbit the Earth after being launched on a heritage Atlas LV-3B rocket.
From raw material to launch, construction of an Atlas V typically takes about 18 months, according to Chassagne.
When the rocket finally flies, it will be the first to carry Boeings new CST 100 Starliner Capsule, which is still in development.
The capsule is slightly larger than an Apollo command module and will be able to carry crews of up to seven to the ISS as well as to private space stations once in service.
After a test flight in June 2018, the capsule is slated to take two astronauts to the ISS in December 2018, launched into space by the Atlas V assembled in Decatur.
ULA marked the successful launch of a National Reconnaissance Office satellite on Wednesday via an Atlas V from Vandenberg Air Force Base in California. It was ULAs second launch of the year. Two more ULA launches are planned this month, both from Cape Canaveral, Florida.
Work on the commercial crew program is not ULAs only current endeavor into manned space flight. ULA is slated to deliver to Cape Canaveral this month the Interim Cryogenic Propulsion Stage, or ICPS, for NASAs new Space Launch System.
Constructed in Decatur, the ICPS will serve as the second stage for the maiden flight of the Space Launch System, or SLS, slated for November 2018. That flight was intended to be an unmanned test mission around the moon using the Orion spacecraft that eventually will carry astronauts to Mars.
But NASA announced last month it is studying options for adding crew to that mission, which will require certifying the ICPS for human flight. The ICPS is a converted upper stage from a ULA Delta IV, which was not designed for manned space flight.
James Muncy, founder of the space policy consultancy PoliSpace, said last week that adding crew would likely delay that launch until after the Starliner launch, noting the life-support system for the Orion capsule wasnt slated for completion until 2021.
He anticipated few problems rating the ICPS of the Atlas V for human flight, which mainly involves analysis and very few changes to its hardware or software.
Neither Atlas V nor Delta IV are intrinsically human rated, but the Atlas V is easy to human rate, and ULA has been working on modifications to it since 2010 as part of the commercial crew program. But both vehicles are very reliable, he said.
A scaled-up version of the SLS with 143 tons of lift capacity is expected to be the launch system that eventually takes astronauts to Mars.
A ULA competitor could still be the first domestic rocket to take Americans to space since the retirement of the shuttle.
California-based SpaceX is slated to fly its new Dragon 2 capsule in May 2018 after an unmanned test flight in November of this year. That capsule is also part of NASAs commercial crew program to serve the ISS.
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This Decatur company is taking humans to space - The Decatur Daily
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A mysterious medical condition gets a name – and a genetic link to deafness – Reading Eagle
Posted: at 3:50 pm
Special To The Washington Post.
He loves dancing to songs, such as Michael Jackson's "Beat It" and the "Macarena," but he can't listen to music in the usual way. He laughs whenever someone takes his picture with a camera flash, which is the only intensity of light he can perceive. He loves trying to balance himself, but his legs don't allow him to walk without support.
He is one in a million, literally.
Born deaf-blind and with a condition, osteopetrosis, that makes bones both dense and fragile, 6-year-old Orion Theodore Withrow is among an unknown number of children with a newly identified genetic disorder that researchers are just beginning to decipher. It goes by an acronym, COMMAD, that gives little away until each letter is explained, revealing an array of problems that also affect eye formation and pigmentation in eyes, skin and hair. The rare disorder severely impairs the person's ability to communicate.
Children such as Orion, who are born to genetically deaf parents, are at a higher risk, according to a recent study published in the American Journal of Human Genetics. The finding has important implications for the deaf community, said its senior author, Brian Brooks, clinical director and chief of the Pediatric, Developmental and Genetic Ophthalmology Section at the National Eye Institute.
"It is relatively common for folks in deaf community to marry each other," he said, and what's key is whether each of the couple has a specific genetic "misspelling" that causes a syndrome called Waardenburg 2A. If yes, there's the likelihood of a child inheriting the mutation from both parents. The result, researchers found, is COMMAD.
Because the disorder was only recently identified, there is much to learn about its impact over a lifetime. Brooks, who estimates that fewer than one person in a million is affected, has seen only a couple cases. Orion is one of them.
The study's finding made things clearer for Heather Withrow, Orion's mother. "It was more like an 'Oh, cool, that explains it!' kind of discovery," she said from Austin, Texas, where the family lives.
When Withrow was pregnant with Orion, she and her husband, Thomas Withrow Jr., suspected that he might be born deaf. While their daughter, 11-year-old Anastasia, has normal hearing, their other son, 12-year-old Skyler, is deaf. Then the results of initial imaging showed their third child would likely be born blind.
A subsequent MRI raised even more worries, suggesting that they were confronting trisomy 13, a chromosomal condition involving devastating physical abnormalities. Her doctor recommended the pregnancy be terminated.
"We just closed that discussion quick," Withrow recalled through an interpreter. "It is sad when people think, 'Oh well, he is going to be disabled so go ahead and end his life.' It's in God's hands. It was not my decision to make, and it wasn't my husband's decision to make."
The couple started to educate themselves about deaf-blindness - a combination that magnifies the effects of each condition. They contacted resources such as Connections Beyond Sight and Sound, a Maryland-based project that helps parents of deaf-blind children. A meeting with one of its specialists was empowering preparation. "It helped us. It let us know that we could celebrate and be happy when he was born, and not be surprised," Withrow said.
Which is what happened. "We fell in love with him at first sight," she said. As she has described on a blog she writes, Orion was long and lean, "with snowy white hair and lashes, ice-melting smile, rich laughter."
Even though he could not see, Orion's right eye would occasionally react to bright light. At just several months of age, he had special prostheses similar to "jumbo" contact lenses - called shells - inserted over his eyeballs to allow the sockets to grow proportionally with his face. And he started physical therapy to improve his motor functions. By the time he was 18 months old, he was able to keep his head straight, his mother said.
COMMAD explains those problems and others, Withrow now knows. It stands for coloboma (a condition in which normal tissue in or around the eye is missing), osteopetrosis (abnormally dense bones prone to fracture), microphthalmia (small or abnormally formed eyes), macrocephaly (abnormal enlargement of the head), albinism (lack of pigment or more specifically melanin in the skin, hair, and eyes) and deafness.
COMMAD can affect Orion in unusual ways. His body clock keeps its own schedule, his mother said, making it difficult for him to distinguish day and night: "He would think it's morning outside at 2 a.m., and he would want to play at a time when we want to go to sleep."
Such differences sometimes wear down his parents. "Despite all that, everything we do with him and everything he learns is so worth it," Withrow said.
She frequently blogs about Orion's experiences - she calls her site "A Mom's Musings" - to help educate people about COMMAD and help other parents interact with deaf-blind children. At home, she and the rest of the family use a touch-based version of American Sign Language - teaching with objects such as a baby bottle, diaper and spoon - to communicate with Orion.
The caveat of the National Eye Institute's recent study is that knowledge about how to care for and interact with children who have COMMAD is still in its infancy, Brooks said. "We are trying to understand the best ways to listen to the children," he said.
For Withow, sharing knowledge is comforting.
"Orion's life is just as important as everyone else's," she said, "and we hope he has the same opportunities as others."
health-commad
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Keywords: deaf-blindness, rare genetic disorder, genetic mutation causing deafness, COMMAD, National Eye Institute
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A mysterious medical condition gets a name - and a genetic link to deafness - Reading Eagle
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CRISPR gene editing tech brings countless opportunities and challenges – Arizona Daily Wildcat
Posted: at 3:50 pm
Ian Green | The Daily Wildcat
Dr. Thomas Doetschman, Ph.D., examines the embryonic cells used to study and implant mutated and disease genes; if the mutated gene successfully imbeds itself into a sperm or egg cell, the resulting rat that is born will be studied to research the effects of that same disease genes in humans. CRISPR CAS9 is technology that allows the splicing of genes to both remove and replace particular DNA strands. CRISPR can affect either just the patient or his descendants as well, depending on the technique used.
Published Mar 5, 2017 6:00am
A new genome editing technology known as CRISPR has the potential to revolutionize the way scientists study diseases and genetics.
I think its a really useful tool for science, in fact its sort of revolutionizing the speed at which we can accomplish certain things in the laboratory and it has tremendous potential for therapeutic applications, said Kimberly McDermott, a research associate professor of medicine and an associate professor of cellular and molecular medicine, cancer biology and genetics.
Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR-Cas9, is based off a bacterial immune system, said Thomas Doetschman, professor of cancer biology, genetics and cellular and molecular medicine.
When bacteria become infected by a virus, they take pieces of the viruss DNA and incorporate it into their own genome. This allows the bacteria to recognize and attack the virus if it ever appears again. This system allows them to destroy the virus, but it also allows them to destroy DNA, Doetschman said.
In developing CRISPR, scientists took a hint from the bacteria.
What it [CRISPR] actually does is causes a mutation at that site, in the DNA, and then repairs it, Doetschman said. And you can repair it in different ways, such that you can actually modify the sequence of the DNA.
This has enormous implications for the study of genetics and combating human diseases. And while it may sound exciting, human gene editing isnt all fun and games.
There are two ways the CRISPR technology can be used in humans, Doetschman said. The first way is to alter somatic cells, which dont get passed down to the next generation. This would only affect the patient who is receiving the treatment.
The second way, known as the germline, can have serious long-lasting effects. Altering genes in the germline can produce permanent changes in the patient that will then be passed on to their children.
Theres two completely different ways of doing this, and the real concern, the big concern, is that it be used by some unscrupulous people to try to change the germline of people, so that you can create progeny that will all have this kind of modification, Doetschman said.
And CRISPR isnt just for humans; it can be used to edit plant cells as well.
It could alter genes in a plant so that the plant either becomes resistant to or susceptible to agents that might otherwise kill the plant, Doetschman said. This could mean disease-resistant plants or increased nutritional content.
One of CRISPRs greatest contributions is in the realm of research, specifically for understanding normal development and disease processes, McDermott said.
For example, in the future scientists may be able to grow human organs from the patients own cells, using CRISPR.
RELATED:Beefy bugs: antibiotic-resistant bacteria pose threat to health
Recent studies on mice and rats have introduced the possibility of using a model organism, such as a pig, to grow human organs, McDermott said.
Another exciting possibility available through CRISPR involves induced pluripotent stem cells, Doetschman said. This process essentially works as a time machine for your cells.
Doetschman describes it as the ability to put your own cells, such as skin cells, in culture and de-differentiate those cells back down to the pluripotent "master key" stem cell, using CRISPR. Once your adult cells are transformed into stem cells, you can make the genetic modifications you'd like, such as correcting a mutation and then re-differentiate the stem cells back into the cell type of the tissue you want to correct.
These cells could potentially be engrafted back into the patients disease tissue, Doetschman said.
Dr. Thomas Doetschman, Ph.D., describes a few of the many functions performed in the workspace pictured, which can effectively seal itself to create a sterile and airtight environment in which researchers can operate. CRISPR technology may redefine the future of genetics.
When it comes to working with human therapeutics, safety and regulations are extremely important, McDermott said. As scientists, their primary concern is to minimize and prevent harm in every way possible.
One of these regulations is a patent that was recently issued to the MIT and Harvard-affiliated Broad Institute, one of the centers responsible for creating CRISPR technology.
RELATED:UA researchers win NIH grant for autoimmune disease work
Despite heavy public controversy surrounding the patent, Doetschman said the patent is a good thing, because it will allow scientists to ensure that CRISPR research is carried out in a safe way, especially in regards to human use.
I think from a scientists perspective, the thing that were really focusing on is trying to listen to our colleagues but also the public in general about what are the fears of this technology, McDermott said. Of course when you start to edit genes and mutate genes theres a lot of concerns about what might happen.
As for the future of human genetics research, both Doetschman and McDermott remain optimistic.
While scientists may have had the ability to make mutations in cells in the past, the results were usually inefficient and could produce off-target effects, McDermott said. CRISPR improves both the efficiency and the accuracy of genome research.
CRISPR might not be the cure to every disease, but it is the key to unlock many avenues of research, Doetschman said.
In terms of the research end of science and medical research, its expanding tremendously the scientists ability to ask questions about genetic disease, Doetschman said.
Doetschman currently uses the CRISPR technology to study mice in his lab on campus. You can readabout his research here.
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CRISPR gene editing tech brings countless opportunities and challenges - Arizona Daily Wildcat
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Research and DNA tests uncovers the unanswered questions of two Kokomo residents – Kokomo Tribune
Posted: at 3:49 pm
KOKOMO -- Barbara Trice hit a wall.
It was the wall of 1860, as she calls it, because she was unable to uncover historical information on her family prior to that year.
I started asking questions and I wrote some things down and I remembered some things as a teenager, Trice said of her research that has spanned years.
As a teenager living with her grandparents, she developed an interest in her ancestry. But it wasnt until five years ago that she decided to really take steps toward uncovering her past.
And it wasnt until June of 2016 the Kokomo-Howard County Public Library was able to assist Trice with her research.
Barbara had a lot of information and I used what she had to start because she knew her family and I didnt, said Amy Russell, head of the librarys Genealogy & Local History Department. And by taking the names that she had, we just took off and ran with it and did the research.
Russell was able to go back six generations in Trices familial history with research and uncovering census data. All of that information was presented Friday evening at the KHCPLs Exploring Your Story, DNA and genealogy research event.
The two-day event presented the genealogical research of two Kokomo residents, Trice and WWKI radio personality Tammy Lively.
For the last nine months, researchers at the library have been uncovering stories from the two womens past. The big reveal Friday showed the women a deeper look into their history, primarily focusing on their paternal sides.
DNA tests that they had taken months prior were also reveled to show their ethnic makeup and origins.
Each woman took two different DNA tests, while Trice took an additional test that was more advanced because of her African heritage.
Because slaves were property, and because they were property they werent recorded, Russell said about Trices need to take a more advanced DNA test.
For African Americans with slave ancestry, it is more difficult to locate documentation that traces a person back to their roots, which is why Trice hit a figurative wall in her own research.
Their names werent recorded, Russell said. With a white family the names keep going on and on, with an African American family at some point, it stops.
But Russell was able to uncover that Trices great-great-great grandfather on her mothers side, Ceasar Wilkerson, was a slave born in 1825 in Virginia. Research also showed that Wilkerson probably served in the U.S. colored troupes in the Civil War.
Like Trice, Lively had also been gathering information on her ancestry for years.
Her mother and grandmother would visit Indianapolis to do research, Lively recalls, resulting in a box full of information she was able to present to researchers.
I had a lot of information for them to start with, but I had barely any information about my fathers side of the family, Lively said.
She imagined that she could be related to royalty, and developed a fascination with the idea.
Ive always been fascinated by all things royal, Lively said. My husband teases me, and the big joke in country radio is [that] Im the queen of my double wide trailer.
But after revealing that her ancestry does in fact include the lineage of England Aristocrats, her jokes can now be backed by facts.
Ive always been fascinated with it, but I never ever dreamed that there was any connection, Lively said in awe following Fridays big reveal.
Research shows that on Livelys fathers side there are connections linking the family to King Henry VIII, who had many wives. From that lineage, a connection to Elizabeth I of England, daughter of Anne Boleyn, the second wife of King Henry VII, is made.
Discovering that she is a distant cousin to Elizabeth I of England left Lively awestruck. Not to mention, uncovering that somewhere down the line Vice President Dick Cheney is also related to Elizabeth I of England, making Lively and Cheney distantly related as well, proved to be the most surprising outcome of the night, Lively admitted.
I feel really compelled to just learn more and more about all the rest of my family, not just the fascinating things I found out about my fathers side today, but my mothers side, Lively said. Its just like an adventure now.
Both Lively and Trice also had their DNA results revealed by genealogy expert Michael Lacopo.
Lively learned she was 27 percent Irish, and also a bit Scandinavian. It was revealed that Trice was 37 percent Ghanaian, also with a sprinkle of Scandinavia.
But that breakdown should not be taken at face value, Lacopo explains, since there are still improvements to be made with ethnic DNA tests.
I always tell people, Ethnic breakdowns are dinner conversation, he said. Theyre interesting, they hold some truth, but they re not hard science.
Because ethnic DNA testing from Ancestry.com, 23andme and a rising number of genomics and biotechnology companies only test from a small database of DNA, its hard to accurately link people to a specific ethnic makeup that would be completely accurate.
The database for Ancestry.com only tests against 3000 people, Lacopo said, and thats not including the DNA of people who lived over 200 years ago.
So theres always going to be fault in those ethnic calculators, Lacopo said.
Going forward, he expects better developments in science. As more people continue to test their biological makeup, databases will increase allowing for more accurate matches, he added.
But the first step in uncovering your history isnt collecting a DNA sample or even searching online. Its talking to the eldest members of your family and collecting all of the historical data you can.
People are not renewable resources, Lacopo said. When they go, theyre gone. So ask lots of questions. Dig through their attics, find all the good stuff.
He added, Its like mining all of the information out of their heads. Heads first, computers second.
And now that Trice and Lively have both experienced how DNA and some research can uncover years of untold stories, they both hope to continue their research because the history never quite ends.
I am so elated, Trice said. I went through an up and a down through the period of time that they were looking because I know how hard it is to break the wall of 1860. But I had decided no matter how little they found or how much they found, that I would be happy with that.
For Lively, this is just the start of her adventure. She hopes others attempt to embark on the same journey.
We should know who we are, she said. It doesnt change my life in any tangible way, but its those wonderful stories that I can pass on to my own granddaughter now. I want her to know her family history.
Correction: An earlier edit identified King Henry VII as having many wives. It has been corrected to King Henry VIII.
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Research and DNA tests uncovers the unanswered questions of two Kokomo residents - Kokomo Tribune
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