Daily Archives: August 8, 2015

DRD4 genotype predicts longevity in mouse and human.

Posted: August 8, 2015 at 1:41 pm

Longevity is influenced by genetic and environmental factors. The brain's dopamine system may be particularly relevant, since it modulates traits (e.g., sensitivity to reward, incentive motivation, sustained effort) that impact behavioral responses to the environment. In particular, the dopamine D4 receptor (DRD4) has been shown to moderate the impact of environments on behavior and health. We tested the hypothesis that the DRD4 gene influences longevity and that its impact is mediated through environmental effects. Surviving participants of a 30-year-old population-based health survey (N = 310; age range, 90-109 years; the 90+ Study) were genotyped/resequenced at the DRD4 gene and compared with a European ancestry-matched younger population (N = 2902; age range, 7-45 years). We found that the oldest-old population had a 66% increase in individuals carrying the DRD4 7R allele relative to the younger sample (p = 3.5 10(-9)), and that this genotype was strongly correlated with increased levels of physical activity. Consistent with these results, DRD4 knock-out mice, when compared with wild-type and heterozygous mice, displayed a 7-9.7% decrease in lifespan, reduced spontaneous locomotor activity, and no lifespan increase when reared in an enriched environment. These results support the hypothesis that DRD4 gene variants contribute to longevity in humans and in mice, and suggest that this effect is mediated by shaping behavioral responses to the environment.

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Rash 101: The Most Common Types of Skin Rashes

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Rash facts Rash is not a specific diagnosis. Instead it means skin inflammation and discoloration that changes the way the skin looks. Common rashes include eczema, poison ivy, hives, and heat rash. Infections that cause rashes may be fungal, bacterial, parasitic, or viral. Over-the-counter products may be helpful treatments for many skin rashes. Rashes lasting more than a few days that are unexplained should be evaluated by a doctor. What are the causes, symptoms, and signs of common noninfectious rashes?

Some common, noninfectious rashes are listed below. If you have a new rash and you have a fever or some other generalized illness associated with it, it would be best to see your doctor.

Seborrheic dermatitis: Seborrheic dermatitis is the single most common rash affecting adults. It produces a red scaling eruption that characteristically affects the scalp, forehead, brows, cheeks, and external ears.

Atopic dermatitis: Atopic dermatitis, often called eczema, is a common disorder of childhood which produces red itchy, weeping rashes on the inner aspects of the elbows and in back of the knees as well as the cheeks, neck, wrists, and ankles. It is commonly found in patients who also have asthma and hay fever.

Contact dermatitis: Contact dermatitis is a rash that is brought on either by contact with a specific chemical to which the patient is uniquely allergic or with a substance that directly irritates the skin. Some chemicals are both irritants and allergens. This rash is also occasionally weepy and oozy and affects the parts of the skin which have come in direct contact with the offending substance. Common examples of contact dermatitis caused by allergy are poison ivy or poison oak (same chemical, different plant) and reactions to costume jewelry containing nickel.

Diaper rash: This is a common type of contact dermatitis that occurs in most infants who wear diapers when feces and urine are in contact with skin for too long.

Stasis dermatitis: This is a weepy, oozy dermatitis that occurs on the lower legs of individuals who have chronic swelling because of poor circulation in veins.

Psoriasis: This bumpy scaling eruption never weeps or oozes and tends to occur on the scalp, elbows, and knees. It leads to silvery flakes of skin that scale and fall off.

Nummular eczema: This is a weepy, oozy dermatitis that tends to occur as coin-shaped plaques in the wintertime and is associated with very dry skin.

Drug eruptions: Certain drugs can produce skin rash as an unwanted side effect. The common appearance is similar to rashes produced by certain common viral infections. On the other hand, drugs may produce a wide variety of other types of rashes.

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Rash 101: The Most Common Types of Skin Rashes

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The Connection Has Been Reset – The Atlantic

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Illustration by John Ritter

Many foreigners who come to China for the Olympics will use the Internet to tell people back home what they have seen and to check what else has happened in the world.

The first thing theyll probably notice is that Chinas Internet seems slow. Partly this is because of congestion in Chinas internal networks, which affects domestic and international transmissions alike. Partly it is because even electrons take a detectable period of time to travel beneath the Pacific Ocean to servers in America and back again; the trip to and from Europe is even longer, because that goes through America, too. And partly it is because of the delaying cycles imposed by Chinas system that monitors what people are looking for on the Internet, especially when theyre looking overseas. Thats what foreigners have heard about.

Theyll likely be surprised, then, to notice that Chinas Internet seems surprisingly free and uncontrolled. Can they search for information about Tibet independence or Tiananmen shooting or other terms they have heard are taboo? Probablyand theyll be able to click right through to the controversial sites. Even if they enter the Chinese-language term for democracy in China, theyll probably get results. What about Wikipedia, famously off-limits to users in China? They will probably be able to reach it. Naturally the visitors will wonder: Whats all this Ive heard about the Great Firewall and Chinas tight limits on the Internet?

In reality, what the Olympic-era visitors will be discovering is not the absence of Chinas electronic control but its new refinementand a special Potemkin-style unfettered access that will be set up just for them, and just for the length of their stay. According to engineers I have spoken with at two tech organizations in China, the government bodies in charge of censoring the Internet have told them to get ready to unblock access from a list of specific Internet Protocol (IP) addressescertain Internet cafs, access jacks in hotel rooms and conference centers where foreigners are expected to work or stay during the Olympic Games. (I am not giving names or identifying details of any Chinese citizens with whom I have discussed this topic, because they risk financial or criminal punishment for criticizing the system or even disclosing how it works. Also, I have not gone to Chinese government agencies for their side of the story, because the very existence of Internet controls is almost never discussed in public here, apart from vague statements about the importance of keeping online information wholesome.)

Depending on how you look at it, the Chinese governments attempt to rein in the Internet is crude and slapdash or ingenious and well crafted. When American technologists write about the control system, they tend to emphasize its limits. When Chinese citizens discuss itat least with methey tend to emphasize its strength. All of them are right, which makes the governments approach to the Internet a nice proxy for its larger attempt to control peoples daily lives.

Disappointingly, Great Firewall is not really the right term for the Chinese governments overall control strategy. China has indeed erected a firewalla barrier to keep its Internet users from dealing easily with the outside worldbut that is only one part of a larger, complex structure of monitoring and censorship. The official name for the entire approach, which is ostensibly a way to keep hackers and other rogue elements from harming Chinese Internet users, is the Golden Shield Project. Since that term is too creepy to bear repeating, Ill use the control system for the overall strategy, which includes the Great Firewall of China, or GFW, as the means of screening contact with other countries.

In America, the Internet was originally designed to be free of choke points, so that each packet of information could be routed quickly around any temporary obstruction. In China, the Internet came with choke points built in. Even now, virtually all Internet contact between China and the rest of the world is routed through a very small number of fiber-optic cables that enter the country at one of three points: the Beijing-Qingdao-Tianjin area in the north, where cables come in from Japan; Shanghai on the central coast, where they also come from Japan; and Guangzhou in the south, where they come from Hong Kong. (A few places in China have Internet service via satellite, but that is both expensive and slow. Other lines run across Central Asia to Russia but carry little traffic.) In late 2006, Internet users in China were reminded just how important these choke points are when a seabed earthquake near Taiwan cut some major cables serving the country. It took months before international transmissions to and from most of China regained even their pre-quake speed, such as it was.

Thus Chinese authorities can easily do something that would be harder in most developed countries: physically monitor all traffic into or out of the country. They do so by installing at each of these few international gateways a device called a tapper or network sniffer, which can mirror every packet of data going in or out. This involves mirroring in both a figurative and a literal sense. Mirroring is the term for normal copying or backup operations, and in this case real though extremely small mirrors are employed. Information travels along fiber-optic cables as little pulses of light, and as these travel through the Chinese gateway routers, numerous tiny mirrors bounce reflections of them to a separate set of Golden Shield computers.Here the terms creepiness is appropriate. As the other routers and servers (short for file servers, which are essentially very large-capacity computers) that make up the Internet do their best to get the packet where its supposed to go, Chinas own surveillance computers are looking over the same information to see whether it should be stopped.

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Portal:Libertarianism – Wikipedia, the free encyclopedia

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The Cato Institute is a libertarian think tank headquartered in Washington, D.C. It was founded in 1977 by Edward H. Crane, who remained president and CEO for 35 years until 2012 when he was replaced by John A. Allison, and Charles Koch, chairman of the board and chief executive officer of the conglomerate Koch Industries, Inc., the second largest privately held company (after Cargill) by revenue in the United States.

The Institute's stated mission is "to broaden the parameters of public policy debate to allow consideration of the traditional American principles of limited government, individual liberty, free markets, and peace" by striving "to achieve greater involvement of the intelligent, lay public in questions of policy and the proper role of government." Cato scholars conduct policy research on a broad range of public policy issues, and produce books, studies, op-eds, and blog posts. They are also frequent guests in the media.

Cato scholars were critical of George W. Bush's Republican administration (20012009) on several issues, including the Iraq War, civil liberties, education, agriculture, energy policy, and excessive government spending. On other issues, most notably health care, Social Security, global warming, tax policy, and immigration, Cato scholars praised Bush administration initiatives. During the 2008 U.S. presidential election, Cato scholars criticized both major-party candidates, John McCain and Barack Obama.

The Cato Institute was named the fifth-ranked think tank in the world for 2009 in a study of leading think tanks by James G. McGann, Ph.D. of the University of Pennsylvania, based on a criterion of excellence in "producing rigorous and relevant research, publications and programs in one or more substantive areas of research". It has been called "Washingtons premier libertarian think tank."

Ronald Ernest Paul (born August 20, 1935) is a Republican United States Congressman from Lake Jackson, Texas, a physician, a bestselling author, and the fourth-place finisher in the 2008 Republican presidential primaries.

Originally from the Green Tree suburb of Pittsburgh, Pennsylvania, he graduated from Gettysburg College in 1957, then studied at Duke University School of Medicine; after his 1961 graduation and a residency in obstetrics and gynecology, he became a U.S. Air Force flight surgeon, serving outside the Vietnam War zone. He later represented Texas districts in the U.S. House of Representatives (19761977, 19791985, and 1997present). He entered the 1988 presidential election, running as the Libertarian nominee while remaining a registered Republican, and placed a distant third.

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How Laissez-Faire Made Sweden Rich | Libertarianism.org

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October 25, 2013 essays

Sweden often gets held up as an example of how socialism can work better than markets. But, as Norberg shows, Swedens history in fact points to the opposite conclusion.

Once upon a time I got interested in theories of economic development because I had studied a low-income country, poorer than Congo, with life expectancy half as long and infant mortality three times as high as the average developing country.

That country is my own country, Swedenless than 150 years ago.

At that time Sweden was incredibly poorand hungry. When there was a crop failure, my ancestors in northern Sweden, in ngermanland, had to mix bark into the bread because they were short of flour. Life in towns and cities was no easier. Overcrowding and a lack of health services, sanitation, and refuse disposal claimed lives every day. Well into the twentieth century, an ordinary Swedish working-class family with five children might have to live in one room and a kitchen, which doubled as a dining room and bedroom. Many people lodged with other families. Housing statistics from Stockholm show that in 1900, as many as 1,400 people could live in a building consisting of 200 one-room flats. In conditions like these it is little wonder that disease was rife. People had large numbers of children not only for lack of contraception, but also because of the risk that not many would survive for long.

As Vilhelm Moberg, our greatest author, observed when he wrote a history of the Swedish people: Of all the wondrous adventures of the Swedish people, none is more remarkable and wonderful than this: that it survived all of them.

But in one century, everything was changed. Sweden had the fastest economic and social development that its people had ever experienced, and one of the fastest the world had ever seen. Between 1850 and 1950 the average Swedish income multiplied eightfold, while population doubled. Infant mortality fell from 15 to 2 per cent, and average life expectancy rose an incredible 28 years. A poor peasant nation had become one of the worlds richest countries.

Many people abroad think that this was the triumph of the Swedish Social Democratic Party, which somehow found the perfect middle way, managing to tax, spend, and regulate Sweden into a more equitable distribution of wealthwithout hurting its productive capacity. And so Swedena small country of nine million inhabitants in the north of Europebecame a source of inspiration for people around the world who believe in government-led development and distribution.

But there is something wrong with this interpretation. In 1950, when Sweden was known worldwide as the great success story, taxes in Sweden were lower and the public sector smaller than in the rest of Europe and the United States. It was not until then that Swedish politicians started levying taxes and disbursing handouts on a large scale, that is, redistributing the wealth that businesses and workers had already created. Swedens biggest social and economic successes took place when Sweden had a laissez-faire economy, and widely distributed wealth preceded the welfare state.

This is the story about how that happened. It is a story that must be learned by countries that want to be where Sweden is today, because if they are to accomplish that feat, they must do what Sweden did back then, not what an already-rich Sweden does now.

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Retrofuturism – Wikipedia, the free encyclopedia

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Retrofuturism (adjective retrofuturistic or retrofuture) is a trend in the creative arts showing the influence of depictions of the future produced in an earlier era. If "futurism is sometimes called a 'science' bent on anticipating what will come, retrofuturism is the remembering of that anticipation."[1] Characterized by a blend of old-fashioned "retro" styles with futuristic technology, retrofuturism explores the themes of tension between past and future, and between the alienating and empowering effects of technology. Primarily reflected in artistic creations and modified technologies that realize the imagined artifacts of its parallel reality, retrofuturism can be seen as "an animating perspective on the world."[2] But it has also manifested in the worlds of fashion, architecture, design, music, literature, film, and video games.

The word "retrofuturism," then, combines more recent ideas of nostalgia and retro with older traditions of futurism. A recent neologism, the actual term "retrofuturism" was coined by American Lloyd Dunn[3] in 1983,[4] according to fringe art magazine Retrofuturism, which was published between 1988 and 1993.[5]

Retrofuturism builds on ideas of futurism, but the latter term functions differently in several different contexts. In avant-garde artistic, literary and design circles, Futurism is a long-standing and well established term. But in its more popular form, futurism (sometimes referred to as futurology) is "an early optimism that focused on the past and was rooted in the nineteenth century, an early-twentieth-century 'golden age' that continued long into the 1960s Space Age." [6]

Retrofuturism is first and foremost based on modern but changing notions of "the future". As Guffey notes, retrofuturism is "a recent neologism," but it "builds on futurists fevered visions of space colonies with flying cars, robotic servants, and interstellar travel on display there; where futurists took their promise for granted, retro-futurism emerged as a more skeptical reaction to these dreams."[7] It took its current shape in the 1970s, a time when technology was rapidly changing. From the advent of the personal computer to the birth of the first test tube baby, this period was characterized by intense and rapid technological change. But many in the general public began to question whether applied science would achieve its earlier promisethat life would inevitably improve through technological progress. In the wake of the Vietnam War, environmental depredations, and the energy crisis, many commentators began to question the benefits of applied science. But they also wondered, sometimes in awe, sometimes in confusion, at the scientific positivism evinced by earlier generations. Retrofuturism "seeped into academic and popular culture in the 1960s and 1970s," inflecting George Lucas Star Wars and the paintings of pop artist Kenny Scharf alike".[8] Surveying the optimistic futurism of the early twentieth century, the historians Joe Corn and Brian Horrigan remind us that retrofuturism is "a history of an idea, or a system of ideas--an ideology. The future, or course, does not exist except as an act of belief or imagination."[9]

Retrofuturism incorporates two overlapping trends which may be summarized as the future as seen from the past and the past as seen from the future.

The first trend, retrofuturism proper, is directly inspired by the imagined future which existed in the minds of writers, artists, and filmmakers in the pre-1960 period who attempted to predict the future, either in serious projections of existing technology (e.g. in magazines like Science and Invention) or in science fiction novels and stories. Such futuristic visions are refurbished and updated for the present, and offer a nostalgic, counterfactual image of what the future might have been, but is not.

The second trend is the inverse of the first: futuristic retro. It starts with the retro appeal of old styles of art, clothing, mores, and then grafts modern or futuristic technologies onto it, creating a mlange of past, present, and future elements. Steampunk, a term applying both to the retrojection of futuristic technology into an alternative Victorian age, and the application of neo-Victorian styles to modern technology, is a highly successful version of this second trend. In the movie Space Station 76 (2014), mankind has reached the stars, but clothes, technology, furnitures and above all social taboos are purposely highly reminiscent of the mid-1970s.

In practice, the two trends cannot be sharply distinguished, as they mutually contribute to similar visions. Retrofuturism of the first type is inevitably influenced by the scientific, technological, and social awareness of the present, and modern retrofuturistic creations are never simply copies of their pre-1960 inspirations; rather, they are given a new (often wry or ironic) twist by being seen from a modern perspective.

In the same way, futuristic retro owes much of its flavor to early science fiction (e.g. the works of Jules Verne and H. G. Wells), and in a quest for stylistic authenticity may continue to draw on writers and artists of the desired period.

Both retrofuturistic trends in themselves refer to no specific time. When a time period is supplied for a story, it might be a counterfactual present with unique technology; a fantastic version of the future; or an alternate past in which the imagined (fictitious or projected) inventions of the past were indeed real. Examples include the film Sky Captain and the World of Tomorrow, set in an imaginary 1939, and The Rocketeer franchise, set in 1938, both of which are also examples of the genre known as dieselpunk.[10]Adam Reed's animated comedy series Archer is also set in a retrofuture aesthetic world. The import of retrofuturism has, in recent years, come under considerable discussion. Some, like the German architecture critic Niklas Maak, see retrofuturism as "nothing more than an aesthetic feedback loop recalling a lost belief in progress, the old images of the once radically new."[11]Bruce McCall calls retrofuturism a "faux nostalgia" the nostalgia for a future that never happened.[12]

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