Category Archives: Psoriasis

Living with a visible condition like psoriasis can impact your physical and emotional health.

While the right psoriasis treatment plan can help you manage physical symptoms, connecting with others with this condition can help foster mental and emotional support. That support network can also be a valuable source of advice and information for how to tackle whatever life with psoriasis throws your way.

Not sure where to start your search for psoriasis support? Here are six ways to connect with others who are living with psoriasis.

Finding a local support group in your area is a great way to connect with others who have psoriasis where you live. These groups serve as a space where people meet in person to share their experiences as well as psoriasis management tips.

Local support groups are often run by a facilitator or therapist. Your dermatologist may be able to refer you to an in-person support group near you.

Online support groups give you the chance to easily interact with others who have psoriasis. It can be done from your home without arranging to meet face-to-face. This is comforting for some who wish to remain somewhat anonymous or are looking for instant support.

Online support groups also help you overcome geographic hurdles by allowing you to connect with others who have psoriasis no matter where you live.

The National Psoriasis Foundation recommends signing up with their partner, Kopa for Psoriasis, for online community support. The Psoriasis community forum run by Inspire is another option.

An alternative to group support is talking one-on-one with someone who shares the experience of living with psoriasis. A 2020 meta-analysis of studies concluded that one-on-one peer support is a great source to help with the social aspects of mental health.

If youre looking for this type of personal connection, The National Psoriasis Foundation has a One to One program that matches up people with psoriasis with a mentor. With One to One, you can sign up to receive support, or you can apply to become a mentor through the program.

Many people who are living with psoriasis share their experiences on social media platforms like Instagram or TikTok.

You can engage with these posts by following hashtags like #psoriasis, #psoriasiswarrior, and #psoriasisawareness. Through this process, you can connect with other followers who share your experiences.

Social media is another way to learn whats happening in the psoriasis community, whether near you or in other parts of the world.

The psoriasis community is large and advocates often hold awareness or fundraising events.

The National Psoriasis Foundation has a directory of these types of events on its website. You can simply attend these events as a guest, volunteer to help out, or participate in fundraising. In the process, youll get to know others who are also living with psoriasis.

Conferences are another engagement opportunity.

The National Psoriasis Foundation often hosts virtual or in-person community events. These conferences give you a chance to learn more about psoriasis.

You can also learn whats happening in the psoriasis community and connect with others who are living with the condition.

A support group, either in-person or online, should provide a sense of community where you know youre not alone with psoriasis. It can provide emotional support as well as tried-and-true advice for managing psoriasis from people who have been there.

Not every support group will be the best fit for you. Before you sign up, consider asking these questions to determine if its the right environment for you:

Perhaps the most important question to ask yourself is whether the group feels right for you.

For instance, ask yourself if youre comfortable attending a support group for psoriasis run by someone living with the condition. If not, you might prefer to search for a group thats run by a mental health professional.

A support network is an invaluable resource for anyone living with psoriasis, no matter the source.

Consider participating in support groups in a way that makes you feel comfortable. At first, that may mean just listening to others and helping them through their experience. When youre ready, you may be more willing to open up more about your own life with psoriasis.

Psoriasis can have physical and emotional tolls. It can be hard to communicate what its like to live with the condition.

Connecting with others who understand firsthand can help gain knowledge about whats worked for them all while helping you feel less alone.

Original post:
Psoriasis Support: How to Connect with Others - Healthline

(SACRAMENTO)

Taking bile acids or treatments that regulate their production levels may help control inflammation caused by psoriasis, a chronic skin condition, a UC Davis Health study has found.

Psoriasis, which causes itchy and painful scales and red patches on the skin, is linked to the bodys immune system. The study, published in the Journal of Investigative Dermatology, suggests that bile acids may treat psoriasis by stopping immune T cells from producing a proinflammatory protein known as IL-17A and blocking the immune cell movement to the inflammation site.

Our studies showed that bile acids significantly inhibited skin inflammation without causing apparent systemic adverse effects, said Sam T. Hwang, professor and chair of dermatology at UC Davis Health and senior author of the study.

Bile acids are produced in the liver and secreted into the first part of the small intestine to help digest food. While most bile acids are reabsorbed into the liver, a small portion escapes into the colon. There, they get transformed by the gut microbiota into secondary bile acids including lithocholic acid (LCA), deoxycholic acid (DCA) and 3-oxoLCA.

Bile acids are important in lipid absorption and cholesterol balance in the blood. Previous studies have identified their role as key signaling molecules in regulating skin immunity and inflammatory diseases.

Hwang and his colleagues had previously shown that proinflammatory diets, such as those rich in fats and simple sugars, greatly change the type of bacteria that reside in the gut, possibly resulting in changes to the levels of these secondary bile acids.

Interleukin-23 (IL-23) is a protein generated by the immune cells. It is responsible for many inflammatory autoimmune reactions, including psoriasis. In one of their studies, the researchers injected mice with IL-23 DNA to induce a response mimicking psoriasis-like skin disease.

They found that compared to mice receiving a placebo treatment, all the mice treated by any of the three secondary bile acids had less redness, scaling and ear thickness. The LCA bile acids showed the greatest improvement in ear swelling.

In another test, the scientists gave oral LCA to mice over two days before applying imiquimod, an immune response modifier used in treating skin diseases. They found that LCA-treated mice had less skin inflammation than those not given bile acids.

As oral LCA might cause gut reactions such as diarrhea, constipation, and stomach pain, the researchers also explored giving LCA through intravenous injection in IL-23 treated mice. Similar to LCA taken orally, an LCA injection in mice also improved psoriatic skin signs.

Previously, the researchers found that a type of receptor protein known as chemokine receptor 6 (CCR6), and its binding partner CC chemokine ligand 20 (CCL20), are linked to the inflammation caused by psoriasis. CCR6 is a critical agent for the migration of T cells a type of white blood cells to the injury site.

In this new study, the researchers found that in the IL-23 mouse model, keratinocytes (the dominant cells in the outer skin layer) served as a major source of CCL20 in the skin.

They found that LCA diminished the production of the proinflammatory protein IL-17A, prevented skin cells from producing CCL20, and blocked the development of psoriasis.

Giving bile acids or using treatments that regulate the work of bile acids may be beneficial for controlling psoriatic inflammation, said Zhenrui Shi, visiting assistant researcher in the UC Davis Department of Dermatology and co-lead author on the study. Our work provides an explanation for several prior small pilot studies of oral bile acid supplementation in psoriatic patients that resulted in improvement of their psoriasis.

Using this link, you can download the article for free, until March 24, 2022.

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Co-authors on this study are Xuesong Wu, Mindy Huynh, Timothy Law, William Liakos, Jimmy C. Wu, Daisuke Yamada, Guiyan Yang and Yu-Jui Yvonne Wan at the University of California, Davis; Zhenrui Shi at the University of California, Davis and the Sun Yat-sen University, China; Satya Singh and Joshua M. Farber at the National Institute of Allergy and Infectious Diseases (NIAID).

This study was supported by a National Psoriasis Foundation Discovery Grant and a Guangdong Basic and Applied Basic Research Foundation (2020A1515110320).

Relevant readings:

More here:
Bile acids may improve skin inflammation in patients with psoriasis - UC Davis Health

Incidence of skin diseases such as psoriasis, melanoma, and dermatophytosis is increasing at a rapid rate. They can be more severe if not detected or diagnosed early. These diseases can spread through infection from one individual to another. For early diagnosis of these diseases, skin analysis systems are used. These systems generally include imaging, pigmentation, and other analysis tools.

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Various factors such as increased pollution levels, changed lifestyle, and exposure to environment and variables such as UV rays are affecting the skin health of people across the world negatively. . In order to regularly check the skin health; diagnose various skin diseases and disorders; and take preventive measures, skin analysis is carried out.

Rise in the prevalence of skin diseases and increased concerns among people about their youthfulness are some of the key factors driving the global skin analysis systems market. For instance, as per the U.S. Department of Health and Human Services, more than 3.5 million people are diagnosed with skin cancer in the U.S. every year.

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According to the WHO, around 3.1% adult population in the U.S. was suffering from psoriasis in 200910. Increased exposure of the skin to factors such as UV rays and chemicals, rise in pollution levels, stressful lifestyle, and increased awareness among people about skin health are other factors fueling the global skin analysis systems market. However, stringent regulations regarding product approval and increase in the demand for inexpensive products by consumers are restraining the global skin analysis systems market.

The global skin analysis systems market can be segmented based on product type, application, and region. In terms of product type, the global skin analysis systems market can be divided into skin elasticity, skin pigmentation, skin imaging, and skin condition. The skin pigmentation segment dominates the global market and is expected to maintain its position during the forecast period, owing to detailed analysis of the skin, quick diagnosis, and brilliant image quality offered by skin pigmentation devices.

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The skin imaging segment is expected to expand at a significant CAGR during the forecast period, due to multiple applications of skin imaging in detecting various skin conditions and disorders. Based on application, the global skin analysis systems market can be classified into hospitals, dermatology clinics, and others. The hospitals segment is dominant and is likely to continue its dominance during the forecast period, owing to availability of multiple skin imaging options and devices in hospitals. The dermatology clinics segment is expected to expand at a high CAGR during the forecast period, due to dermatology clinics offer customized services at an affordable price.

In terms of region, the global skin analysis systems market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Among regions, North America is dominant and is expected to lead the global market during the forecast period also. Rise in the prevalence of skin diseases led by increasing geriatric population and highly advanced and developed health care infrastructure in the region are major factors driving the skin analysis systems market in North America. The market in Asia Pacific is expected to expand at a high CAGR in the next few years, due to increase in awareness regarding skin care and rise in the health care expenditure.

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The global skin analysis systems market is highly fragmented, due to presence of a large number of companies in the market. Key players operating in the global market are Bio-Therapeutic Inc., Callegari Srl, Visiomed Group SA, Canfield Scientific, Inc., Davi & Cia, DJM Medical Instrument GmbH, BOMTECH ELECTRONICS CO., Ltd., DermoScan GmbH, CYNOSURE, and Cortex Technology.

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Original post:
Skin Analysis Systems Market: The Skin Pigmentation Segment Dominates the Global Market - BioSpace

A randomized, placebo-controlled study of 25,000 older adults found those who took vitamin D, or vitamin D and omega-3 fatty acids, had a significantly lower rate of autoimmune diseases such as rheumatoid arthritis and psoriasis compared with people who took a placebo. The study was part of the larger, nationwide VITAL trial, and the findings were published January 26 in theBMJ.

It is exciting to have these new and positive results for nontoxic vitamins and supplements preventing potentially highly morbid diseases, said the study's senior author,Karen Costenbader, MD, MPH, a professor at Harvard Medical School and the director of the lupus program at Brigham and Womens Hospital, both in Boston, in a news release.

This is the first direct evidence we have that daily supplementation may reduce autoimmune disease incidence, and what looks like a more pronounced effect after two years of supplementation for vitamin D, said Dr. Costenbader.

A normally functioning immune system helps prevent illness from infection and disease, but in a person with autoimmune disease, the immune system is too active and mistakenly attacks the bodys own cells and tissues.

There are more than 80 known autoimmune diseases, including conditions such as multiple sclerosis, lupus, rheumatoid arthritis, and type 1 diabetes. Approximately 5 to 8 percent of people more than 24 million in the United States live with an autoimmune disorder, according to the National Institute of Environmental Health Sciences (NIEHS).

Experts dont know how autoimmune diseases occur; they arent contagious. A hereditary link is present in many autoimmune conditions, and it may be that a virus or an environmental factor triggers the disease if a person already has the genes for it, per the NIEHS.

There is some evidence that certain autoimmune diseases are related to vitamin D levels, and some autoimmune conditions, such as MS, are more common in northern latitudes where vitamin D levels are, on average, lower because of low sun exposure, according to the National Multiple Sclerosis Society.

Several clinical trials, including a meta-analysis published in the Journal of Clinical Rheumatology, have found that omega-3 fatty acids taken in the form of fish oil supplements may improve the symptoms of some autoimmune diseases.

The original VITAL study was a randomized, double-blind, placebo-controlled trial of 25,871 people that observed the effects of vitamin D and omega-3 fatty acid supplementation on different types of cancer and cardiovascular disease, including heart attack and stroke. Participants were 71 percent non-Hispanic white, 20 percent Black, and 9 percent other racial or ethnic groups; 51 percent were women, and the average age was 67.1 years old.

Before the start of that trial, researchers also planned to examine whether the supplements would have any impact on how many people developed an autoimmune disease as part of an ancillary study. After a median follow-up of 5.3 years, researchers found the following results:

But the study did find evidence of an increased effect of the omega-3 fatty acid supplement after a longer duration of supplementation.

The study is fascinating, says Elizabeth Bradley, MD, the medical director of Cleveland Clinics Center for Functional Medicine in Ohio, who was not involved in this research. The researchers saw a significant decrease in the development of autoimmune disease after supplementing with vitamin D, she says.

At the Center for Functional Medicine, Dr. Bradley and a team of healthcare providers run groups for people with different types of autoimmune disorders.

These findings fit with what we see in real life; we routinely check vitamin D and omega levels in people with autoimmune diseases, and I would say 99 percent of the time, they are low in both unless they are taking a supplement already or eating a diet high in fatty fish, she says.

Although these findings make Bradley want to recommend supplements to almost everyone, she does think its a good idea to get your levels checked first. Research indicates that people whose vitamin D levels place them in the lowest quartile would likely get the most benefit from taking a supplement, she says.

To reduce the risk of autoimmune disease in women age 55 years and older and men 50 years and older, Costenbader recommends 2,000 international units (IU) ofvitamin D a day and 1,000 milligrams (mg) a day of marine omega-3 fatty acids (fish oil) the doses used in VITAL.

Its a good idea to check in with your doctor before taking supplements, says Bradley. We do have to be careful with vitamin D supplementation because it is stored in our fat and can accumulate in the body, she says. Though it isnt very common, taking very large doses could result in toxicity, according to the National Institutes of Health.

Fish oil supplements can vary in quality, says Bradley. Your provider may have suggestions on what to look for in labeling, or you can research different brands at independent websites such as ConsumerLab.com, which reviews and rates supplements.

Read more from the original source:
Vitamin D and Fish Oil Supplement May Reduce the Risk of Autoimmune Disease - Everyday Health

Symptoms can start at any age, but the first signs of psoriasis often occur between the ages of 15 and 25, according to the National Psoriasis Foundation.

When psoriasis first appears, you start to notice symptoms of inflammation on your skin. This can include:

As the condition progresses, symptoms can start to worsen or become more noticeable.

Symptoms can vary based on the type of psoriasis (well get to the seven main subtypes in a sec), the amount of psoriasis, and the area thats affected.

While psoriasis can show up anywhere on your body. It most commonly develops on your:

The features, feels, and early symptoms of psoriasis might often depend on what type you have.

Plaque psoriasis is the most common type, affecting 80 to 90 percent of people with the condition.

This form of psoriasis usually first appears as thick, raised patches of skin aka plaques. These plaques can be red, purple, or silver and often vary in size. Over time, they may start to feel dry and scaly, which can cause them to itch like crazy.

Guttate psoriasis appears as tiny bumps that may pop up suddenly on your skin. These bumps, or spots, are usually red or pink and have a scaly texture.

Guttate psoriasis often begins to show up on your arms, legs, or torso, but the condition can develop in other areas.

Guttate spots are known to clear up on their own and sometimes never make a return appearance. No one really knows why this happens, making guttate psoriasis one of the more mysterious psoriasis types.

While other forms of psoriasis are raised and rough to the touch, inverse psoriasis causes flat, raw-looking rashes in folds of the skin. These reddish or purple rashes are usually smooth to the touch, but that doesnt make them any less uncomfortable.

Inverse psoriasis usually develops in areas where skin is constantly rubbing on skin (like the armpits, under boob area, and even the genitals). This can cause increasing levels of soreness or discomfort over time especially when sweat gets trapped in these folds.

When it comes to pustular psoriasis, youll usually see puss-filled bumps often appearing on your hands and feet. These small, inflamed bumps can typically be confused for acne when they first appear.

But youll def be able to tell the difference as the condition progresses. The skin underneath the pus-filled bumps will become red and swollen. The area can also become itchy and sore.

As the bumps dry out, theyre usually replaced with scaly, brown dots.

If you start to experience symptoms of erythrodermic psoriasis, call the doctor STAT.

This rare, severe form of psoriasis can cause large chunks of skin to shed, leading to debilitating pain. It can also cause an elevated heart rate, dehydration, fever, chills, and muscle weakness. Erythrodermic psoriasis can also lead to hypothermia, making it difficult to stay warm.

Erythrodermic psoriasis spreads fast, causing visible inflammation in nearly 90 percent of your body. This condition can resemble a burn at first, with the skin becoming red, dry, and tender to the touch. You may experience intense itching as the rash spreads.

Most cases of erythrodermic psoriasis occur in people who already have another form of psoriasis. Talk with your dermatologist ASAP if you notice your condition becoming worse or not responding to treatment, as this condition can be life threatening.

Nail psoriasis affects well, your nails (obvi). Nail psoriasis is pretty common, impacting about 50 percent of people who already have another type of psoriasis.

At first, you may notice discoloration of your nails (usually yellow, white, or brownish hues), as well as pitting in your nails themselves. As the condition develops, larger dents in the nail may form, and the nail may become rough and crumbly.

Skin cells can also build up underneath your nails, causing the nail to lift and detach from the skin of your finger or toe.

Psoriatic arthritis (PsA) gets under your skin literally. This subtype affects the joints and most often occurs in people who already have psoriasis. It can develop at any age, most commonly appearing between ages 30 and 50.

Early signs of PsA can include swollen or tender joints, swelling on the knee or back of the leg, and pain on or around your heel. You may also notice stiffness, specifically in the mornings (because getting out of a cozy bed isnt hard enough sometimes!).

Its important to seek treatment for PsA. Ignoring the condition might lead to difficulty moving and even physical disability.

Originally posted here:
Early-Stage Beginning of Psoriasis: Symptoms and Types - Greatist

This article was originally published here

Dermatol Ther (Heidelb). 2022 Feb 1. doi: 10.1007/s13555-022-00684-3. Online ahead of print.

ABSTRACT

INTRODUCTION: Dimethyl fumarate (DMF) is approved as oral systemic treatment for moderate-to-severe psoriasis. Scarce evidence is available for DMF treatment in psoriatic patients at the time of COVID-19 pandemic. The objective of this study was to assess the long-term effectiveness and safety of DMF monotherapy in moderate-to-severe psoriasis during the COVID-19 pandemic period.

METHODS: This multicenter, retrospective study included patients with moderate-to-severe psoriasis who had received a 48-week DMF treatment during the COVID-19 pandemic. Selected outcomes were: variation of mean PASI, proportion of patients achieving PASI50 and PASI75, variation of mean PGA and face PGA, genital PGA, scalp PGA, mean itch VAS and mean DLQI.

RESULTS: Forty-four patients were enrolled, and four patients became COVID-19 positive during the observation period but did not discontinue DMF therapy. DMF produced a significant improvement of signs and symptoms of psoriasis as expressed by mean PASI variation from 13.07 at baseline to 6.11 at week 48 (p < 0.0001), itch VAS from 3.22 at baseline to 1.18 at week 48 (p < 0.001), PGA from 2.84 at baseline to 1.30 at week 48 (p < 0.0001) and DLQI from 13.09 at baseline to 6.07 at week 48 (p < 0.0001). The percentage of patients who achieved PASI50 and PASI75 was 4.55% at week 4 and 59.09% at week 48 and 0% at week 4 and 22.73% at week 48, respectively. A clinical important decrease of mean PGA score was observed in all subgroups, face psoriasis, genital psoriasis and scalp psoriasis. Adverse events were predictable and manageable.

CONCLUSIONS: DMF monotherapy is an effective and safe treatment option in moderate-to-severe psoriasis also in patients who develop SARS-CoV-2 infection.

PMID:35103934 | DOI:10.1007/s13555-022-00684-3

Read more:
Dimethyl Fumarate's Effectiveness and Safety in Psoriasis: A Real-Life Experience During the COVID-19 Pandemic - DocWire News

Latest Plaque Psoriasis Treatment Market report added by In4Research provides major industry dynamics such as growth drivers, current and future trends, latest developments, threats, challenges, and opportunities in the global market are deeply analyzed. The competitive landscape of the Global Plaque Psoriasis Treatment Market, along with the profiles of the major companies is presented in the report. Regional Market analysis covers North America, China, Africa, Germany, APAC, and more regions have been analyzed individually for a more granular view of the performance of each region in the Plaque Psoriasis Treatment Market and the varying reasons for its positive and negative growth.

The Plaque Psoriasis Treatment Market Report Covers Major Players:

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The report on the Plaque Psoriasis Treatment market provides a brief overview of the market along with the product definition and market scope. The sections following the introductory chapter provide an in-depth study of the market based on extensive research analysis. Along with the market dynamics, the report also presents a comprehensive analysis of the market covering the supply and demand forces.

Plaque Psoriasis Treatment Market Segmentation:

The global market for Plaque Psoriasis Treatment is set to find a segmentation in the report that would be based on type and application. These segments have a better acceptance of various factors that can be taken into consideration to understand how the market can chart the future path.

Plaque Psoriasis Treatment Market Breakdown based on Product Type:

Plaque Psoriasis Treatment Market Breakdown based on Application:

Plaque Psoriasis Treatment Consumption Breakdown Data by Region

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Key Topics Covered in Plaque Psoriasis Treatment Research Study are:

5.1 Introduction

5.2 Market Dynamics

5.3 COVID-19 Pandemic-Driven Market Dynamics and Factor Analysis

6.1 Introduction

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6.3 Porters Five Forces Analysis

6.4 Pricing Analysis

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9 Plaque Psoriasis Treatment Market, By Region

10.1 Overview

10.2 Market Evaluation Framework

10.3 Estimated Market Share Range of Key Players

11.1 Overview

11.2 Competitive Leadership Mapping

In4Research narrows down the available data using primary sources to validate the data and use it in compiling a full-fledged market research study. The report contains a quantitative and qualitative estimation of market elements that interests the client. The Global Plaque Psoriasis Treatment Market is mainly bifurcated into sub-segments which can provide classified data regarding the latest trends in the market.

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PARIS--(BUSINESS WIRE)--CTMA, a clinical research service company that is working to change the way patients are detected for clinical trials, announced that it is expanding its CT-SCOUT technology offering into a second therapeutic area rheumatology. CT-SCOUT, the companys multi-device platform that allows health care professionals (HCP) to identify trial candidates, will now be available for sites, sponsors and contract research organizations (CROs) in three rheumatological indications: Rheumatoid Arthritis, Ankylosing Spondylarthritis and Psoriatic Rheumatism.

Pierre Pellier, Chief Executive Officer of CTMA, said: We are thrilled to expand our platform by adding a new therapeutic area. This enables us to support a larger pool of patients, studies, sites and sponsors. Rheumatoid Arthritis, Ankylosing Spondylarthritis and Psoriatic Rheumatism, are chronic, debilitating diseases that affect a large population of patients for whom clinical trials may represent an important therapeutic alternative solution.

Building on its successful experience in inflammatory bowel disease (IBD), CTMA plans to continue expanding its offering to include additional therapeutic areas in order to accelerate clinical research. Currently, a majority of clinical trials are delayed and up to 10% of trials are never completed. CTMAs technology allows healthcare providers to use an app in real-time alongside a patient, to efficiently identify trials running at the site that will match the patients profile.

Patients suffering from Rheumatoid Arthritis, Ankylosing Spondylarthritis and Psoriatic Rheumatism are still looking for new therapies as there is a large unmet medical need. Ultimately, the goal of CTMAs app-based technology is to help bring innovative therapies to patients faster.

Dr. Emmanuelle Dernis-Labous, a rheumatology expert at the Hospital Center of Le Mans, said: Developing a recruitment algorithm for clinical trials focused on three major rheumatology indications has been a fascinating exercise. This will contribute to making clinical trials more visible and more accessible to patients suffering from these chronic diseases, who are in need of alternative therapeutic options.

About CTMA:

CTMA is a clinical research service company that is working to change the way patients are detected for clinical trials. Based in Paris, the company has developed an innovative solution to address the critical patient detection problem that affects most clinical trials. In 2014, CTMA launched its innovative, patented methodology and application, to increase recruitment in clinical studies. Since then, CTMA has successfully worked with the larger sponsors in inflammatory bowel disease (IBD) ulcerative colitis (UC) and Crohns disease (CD), where it demonstrated that sites equipped with its solution can recruit by up to four times more than non-equipped sites1.

More than 250 investigational sites have benefited from this unique solution so far. For more information, please visit: http://www.ctma.fr.

_________________1Ref: Bouhnik Y, et al. Gastroenterology 2020- https://www.gastrojournal.org/article/S0016-5085(20)30371-1/pdf

See the rest here:
CTMA Expands Its Digital Clinical Trial Solution to a Second Therapeutic Area Rheumatology - Business Wire

Psoriasis is a chronic immune mediated inflammatory disorder that affects approximately 2% of the world population or 140 million people worldwide. In the U.S, approximately 7.4 million adults have psoriasis. This chronic disease is known for its effects on the skin, which occurs when the immune system mistakenly triggers skin cells to overgrow. As a result, the life cycle of cells is sped up and an excess of them can form inflamed patches of skin that may occur anywhere on the body, especially on the elbow, knees, lower back and scalp. Often times, psoriasis has a genetic component, and is known to run in families.

Psoriasis may be associated with diseases of other organs. In fact, according to the Centers for Disease Control and Prevention (CDC), about 10% - 20% of people with psoriasis also suffer from psoriatic arthritis, which causes joint pain and stiffness, and joint destruction (in severe cases). Additionally, research suggests that people living with psoriasis may also have an increased risk for heart disease, stroke, depression and other immune diseases.

Psoriasis can occur in children or adults, however, peak onset of psoriasis often occurs between the ages of 16 to 22 years, or between the ages of 57 and 60 years. The way symptoms appear and their seriousness may vary greatly depending on the type, form and severity of disease.

Psoriasis generally occurs as redness on the skin, raised areas (called plaques or lesions), and silvery white patches (called scales). Other forms of psoriasis can cause additional types of skin conditions. These may include small red spot-like lesions that show up after a bacterial infection (such as strep throat), pus-filled bumps, or intensely sore red patches in body folds (i.e., arm pits, groin, under the breast).

Most often, in psoriasis, the affected skin is found on elbows, knees, lower back, and scalp, though patches can appear just about anywhere. Other places on the body can include face, genitals, fingernails, palms of the hands, and soles of the feet.

Its important to tell your doctor about any skin problems you may be having.While not all skin irregularities are psoriasis, its important to show them to your doctor for an accurate diagnosis, as skin problems can be signs of other illnesses.

There are many different treatment options. Typical therapies include topical treatments (medicine applied to the skin), phototherapy (treatment with ultraviolet light therapy), treatment taken by mouth or injection (conventional therapy), and treatments called biologic (injections or infusions) which target specific immune-system proteins known to play a role in psoriasis inflammation.

With psoriasis, response to therapy may vary by person. Some people will try several approaches until finding one that works well; others will try more than one therapy at a time. Diagnosis, understanding patients needs, appropriate treatment, and check-ins to see if the management plan should continue or be modified are key toward reaching the goals agreed upon by people with psoriasis and their health care teams.

Not everybody understands psoriasis. Some people see skin lesions and fear they will get the disease from being near a person with psoriasis or by touching their skin. People with psoriasis are sometimes asked to leave public places like gyms or pools. This may cause undue stress to someone living with psoriasis, and is completely based on false notions.

Psoriasis is not something you can catch, or that others can catch from you. It is not contagious. Because symptoms on the skin are often visible, coping with other peoples reactions to lesions or plaque can be part of managing psoriasis.Today people living with the disease and their advocates are working to highlight the facts about psoriasis and change the biases based on unfounded fears.

Lotus Mallbris, MD, PhD, was a Senior Medical Director and the global medical lead across several investigational dermatology programs at Pfizer.

Mandeep Kaur, MD, MS was the Therapeutic Team Lead in Dermatology during her employment at Pfizer.

See the article here:
Living with Psoriasis: Beyond Just Skin | Pfizer

Psoriasis is a skin condition that creates red patches of skin with white, flaky scales. It most commonly occurs on the elbows, knees and trunk, but can appear anywhere on the body. The first episode usually strikes between the ages of 15 and 35. It is a chronic condition that will then cycle through flare-ups and remissions throughout the rest of the patient's life. Psoriasis affects as many as 7.5 million people in the United States. About 20,000 children under age 10 have been diagnosed with psoriasis.

In normal skin, skin cells live for about 28 days and then are shed from the outermost layer of the skin. With psoriasis, the immune system sends a faulty signal which speeds up the growth cycle of skin cells. Skin cells mature in a matter of 3 to 6 days. The pace is so rapid that the body is unable to shed the dead cells, and patches of raised red skin covered by scaly, white flakes form on the skin.

Psoriasis is a genetic disease (it runs in families), but is not contagious. There is no known cure or method of prevention. Treatment aims to minimize the symptoms and speed healing.

There are five distinct types of psoriasis:

People who have psoriasis are at greater risk for contracting other health problems, such as heart disease, inflammatory bowel disease and diabetes. It has also been linked to a higher incidence of cardiovascular disease, hypertension, cancer, depression, obesity and other immune-related conditions.

Psoriasis triggers are specific to each person. Some common triggers include stress, injury to the skin, medication allergies, diet and weather.

Psoriasis is classified as Mild to Moderate when it covers 3% to 10% of the body and Moderate to Severe when it covers more than 10% of the body. The severity of the disease impacts the choice of treatments.

Mild to moderate psoriasis can generally be treated at home using a combination of three key strategies: over-the-counter medications, prescription topical treatments and light therapy/phototherapy.

The U.S. Food and Drug Administration has approved of two active ingredients for the treatment of psoriasis: salicylic acid, which works by causing the outer layer to shed, and coal tar, which slows the rapid growth of cells. Other over-the-counter treatments include:

Prescription topicals focus on slowing down the growth of skin cells and reducing any inflammation. They include:

Controlled exposure of skin to ultraviolet light has been a successful treatment for some forms of psoriasis. Three primary light sources are used:

Treatments for moderate to severe psoriasis include prescription medications, biologics and light therapy/phototherapy.

Oral medications. This includes acitretin, cyclosporine and methotrexate. Your doctor will recommend the best oral medication based on the location, type and severity of your condition.

Biologics. A new classification of injectable drugs, biologics are designed to suppress the immune system. These tend to be very expensive and have many side effects, so they are generally reserved for the most severe cases.

Light Therapy/Phototherapy. Controlled exposure of skin to ultraviolet light has been a successful treatment for some forms of psoriasis. Two primary light sources are used:

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Psoriasis - Melbourne, FL Dermatologist