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Category Archives: Eczema

Should You Try an Elimination Diet to Determine the Root Cause of Eczema? – Everyday Health

Posted: October 12, 2019 at 12:47 pm

If youre living with eczema or atopic dermatitis, you know targeting your triggers and keeping your skin moisturized are two essentials for happy, healthy skin. When it comes to eczema triggers, there are some known culprits think fragrance, laundry detergent, hot or cold weather, and even stress notes the National Eczema Association.

Yet what you put at the end of your fork may also play a role in your risk for flare-ups.

Typically, after eating a triggering food, your skin will get itchy or red. You may also notice swollen, hive-like patches or a flare of preexisting lesions, past research suggests. The symptoms may not be immediate they could take a few hours or up to two days to appear.

To identify those triggers in yourself or your infant, maybe youve considering trying an elimination diet. This involves avoiding specific foods that you think are responsible for your symptoms, according to the University of Wisconsin in Madison School of Medicine and Public Health. These diets are used mainly to identify triggers for health conditions such as irritable bowel syndrome, autoimmune disorders such as rheumatoid arthritis or multiple sclerosis, and migraines. Sometimes, people with eczema try them, too, if they suspect food is triggering their symptoms.

Indeed, according to the aforementioned research, infants with moderate to severe eczema are more likely to have food allergies, so identifying the foods that trigger their allergy symptoms may also help control eczema.

RELATED: Researchers Identify Subtype of Eczema Tied to Food Allergies

Everyone responds to foods differently not everyone with eczema will have the same reaction to milk, for instance so an elimination diet may not be the right tool to add to your arsenal against eczema.

The University of Wisconsin in Madison outlines these general steps for following an elimination diet:

RELATED: 7 Types of Eczema and What They Look Like

It can be but not always, says Susan Bard, MD, a board-certified dermatologist with Vive Dermatology Surgery & Aesthetics in Brooklyn, New York. According to the American Academy of Allergy, Asthma & Immunology, foods are a trigger in 20 to 30 percent of moderate to severe eczema cases.

Dr. Bard says an elimination diet for eczema is worth trying only if it seems clear that a food is to blame for an outbreak. I tell patients that if they see an obvious association between a certain food and eczema flares to avoid that food, she says.

Alice Hoyt, MD, an allergist and clinical immunologist with Cleveland Clinic in Ohio, also doubts food is always to blame. The reason we don't recommend elimination diets to modify atopic dermatitis is because there's no evidence that it will actually change the disease process because foods are not causing atopic dermatitis, she says. She says it might seem like theres a link because eczema patients are at increased risk of developing other allergies, including food allergies, but says its much more beneficial to look at what people are putting on their skin rather than what theyre eating.

RELATED: The Connection Between Eczema and Diet

The downside of elimination diets is they can lead to unbalanced eating because you may rule out entire food groups in an effort to find your trigger, Bard says. This excessive restriction can lead to nutritional deficiencies, according to a past study. Thats why Dr. Hoyt pairs patients who are trying an elimination diet with a registered dietitian, who can advise them on how to source necessary nutrients. For instance, if you eliminate dairy, youll need to find other ways to meet your calcium needs. The point is to optimize good nutrition, she says.

Another major downside is that elimination diets could lead to increased intolerance and more immediate sensitivity to the food in the future. A study published in the March-April 2016 issue of The Journal of Allergy and Clinical Immunology: In Practice found that after confirming food-triggered eczema, about 19 percent of participants had an immediate negative reaction when they were next exposed to the ingredient, which had never happened before. Rather than eliminating the food completely, the researchers suggest a better approach would be to determine how much of the ingredient your body can handle and incorporate that amount into your diet.

RELATED: A Detailed Guide to Treating Eczema

According to The Journal of Allergy and Clinical Immunology: In Practice study, the most common triggers for 183 study participants were milk (57.5 percent), eggs(30.6 percent), and soy (21 percent). Daniel P. Friedmann, MD, a board-certified dermatologist with Westlake Dermatology in Austin, adds wheat and peanuts to the list of common allergens for people with eczema, anda past article notes fish is another usual suspect.

RELATED: How to Target Eczema Triggers

Though youre likely used to visiting your dermatologist for eczema, if a food allergy could be in play, its best to see an allergist as well.

Dr. Friedmann says your dermatologist will likely recommend you visit a board-certified allergy specialist to determine what food allergies you have and to advise on whether an elimination diet will be right for you.

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Long-Term Dupilumab Safe, Effective in Adolescents with Atopic Dermatitis – Pharmacy Times

Posted: at 12:47 pm

Study: Long-Term Dupilumab Safe and Effective in Adolescents with Atopic Dermatitis

The results reinforced findings from an earlier short-term study that showed dupilumab can significantly improve AD in adolescents. The study, published in the British Journal of Dermatology, examined the long-term efficacy and safety profile of dupilumab in adolescents with inadequately controlled, moderate-to-severe AD.

Up until recently, there was a high unmet medical need for adolescents with AD, for which treatments typically included topical therapies that did not have long-term applicability. AD can have substantial detrimental effects on health-related quality of life (QoL) in adolescents, often linked with depression, anxiety, and attention deficit-hyperactivity disorder as well as a greater risk of asthma, allergic rhinitis, and food allergy.

Dupilumab, a monoclonal antibody that blocks the shared receptor component for interleukin (IL)-4 and IL13, has demonstrated a favorable benefit-to-risk safety profile, improved disease severity and symptoms, and improved scores for anxiety, depression, and QoL in adults with AD.

For this phase 2a study, 40 adolescents received 1 dupilumab dose and 8 weeks of pharmacokinetic sampling. Patients then received the same dose weekly for 4 weeks, with 8-week safety follow-up. Thereafter, 36 patients were enrolled in the ongoing phase 3 open-label extension (OLE) study.

Overall, mean SD trough dupilumab concentrations in serum at week 48 in the OLE trial were 74 19 mg L-1 and 161 60 mg L-1 for 2 mg kg-1 and 4 mg kg-1, respectively. Additionally, dupilumab was well tolerated over 52 weeks, with the most common treatment-emergent adverse effects being nasopharyngitis (week 52: 41% [2 mg kg-1], 47% [4 mg kg-1]) and AD exacerbation (29%, 42%). No new safety signals were observed and the safety profile was comparable with the known safety profile of dupilumab in adults.

The study also showed that, with continuing treatment, Eczema Area and Severity Index (EASI) scores improved [week 52: -85% 12% (2 mg k-1) and -84% 20% (4mg kg-1)].

Adolescents with moderate-to-severe atopic dermatitis have a high disease burden that negatively affects quality of life, and patients are in need of therapies that can be used long-term, senior author Ashish Bansal, MD, of Regeneron Pharmaceuticals, said in a statement. Results from these trials show that dupilumab provides substantial and sustained clinical benefit to these patients with an acceptable safety profile.

According to the study authors, in addition to the studies demonstrating the long-term efficacy and safety of dupilumab in adolescents for up to 52 weeks of treatment, the data also support the use of dupilumab in combination with topical corticosteroids.

These 52-week safety and efficacy data support long-term use of dupilumab in this patient population, the authors concluded.

References

Cork MJ, Thaci D, Eichenfield LF, et al. Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase 2a open-label trial and subsequent phase 3 open-label extension. British Journal of Dermatology. 2019. https://doi.org/10.1111/bjd.18476

Long-Term Dupilumab Benefits Adolescents with Eczema [news release]. Wiley. https://newsroom.wiley.com/press-release/british-journal-dermatology/long-term-dupilumab-benefits-adolescents-eczema. Accessed October 9, 2019.

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Pfizer Presents Positive Phase 3 Data at the 28th Congress of the European Academy of Dermatology and Venereology for Abrocitinib in Moderate to…

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NEW YORK--(BUSINESS WIRE)--Pfizer Inc. (NYSE: PFE) announced today complete results from a Phase 3, 12-week, pivotal study (JADE MONO-1) in patients aged 12 and older with moderate to severe atopic dermatitis (AD). Abrocitinib, an investigational oral Janus kinase 1 (JAK1) inhibitor, met all the co-primary and key secondary endpoints, which were related to skin clearance and itch relief compared to placebo. Safety data showed that both evaluated doses of abrocitinib (200mg and 100mg) were well tolerated and were consistent with a companion study (JADE MONO-2) from the JAK1 Atopic Dermatitis Efficacy and Safety (JADE) global development program. The results were shared as a Late-Breaking presentation at the 28th Congress of the European Academy of Dermatology and Venereology (EADV) taking place October 9-13, 2019 in Madrid, Spain.

The co-primary study endpoints in JADE MONO-1 were the proportion of patients who achieved an Investigator Global Assessment (IGA) score of clear (0) or almost clear (1) skin and two-point or greater improvement relative to baseline; and the proportion of patients who achieved at least a 75% or greater change from baseline in their Eczema Area and Severity Index (EASI) score. The key secondary endpoints were the proportion of patients achieving a four-point or larger reduction in itch severity measured with the pruritus numerical rating scale (NRS), and the magnitude of decrease in the Pruritus and Symptoms Assessment for Atopic Dermatitis (PSAAD), a patient-reported measurement scale developed by Pfizer. Other secondary endpoints included the proportion of patients who achieved a 90% or greater change in EASI score, and the percentage change from baseline in their SCORing Atopic Dermatitis (SCORAD) response at all scheduled time points.

There is a critical need for additional treatment options for patients living with moderate to severe atopic dermatitis, said Michael Corbo, PhD, Chief Development Officer, Inflammation & Immunology, Pfizer Global Product Development. We are pleased by these findings, which together with the recently reported positive top-line results from our second Phase 3 trial, encourage us that, if approved, abrocitinib may provide the first oral, once-daily treatment option for these patients.

JADE MONO-1 Study Efficacy Results1

Both doses of abrocitinib significantly improved the IGA and EASI-75 dose response outcomes compared to placebo. By week 12, the following co-primary efficacy and secondary endpoint results were seen:

Abrocitinib200mg (N=154)

Abrocitinib100mg (N=156)

Placebo (N=77)

IGA Response Rate

43.8%

23.7%

7.9%

EASI-75 Response Rate

62.7%

39.7%

11.8%

NRS 4-Point Improvement Response Rate

57.2%

37.7%

15.3%

EASI-90 Response Rate

38.6%

18.6%

5.3%

The percentage changes in SCORAD were significantly greater at all time points in the 200mg and 100mg treatment arms compared to placebo.

JADE MONO-1 Safety Results1

The most frequently reported treatment-emergent adverse events in abrocitinib-treated patients (200mg, 100mg) were short-lasting nausea (20.1%, 9.0%), headache (9.7%, 7.7%), and nasopharyngitis (11.7%, 14.7%), while for placebo, it was dermatitis (16.9%). Observed serious adverse events (SAEs) for abrocitinib 200mg were inflammatory bowel disease, peritonsillitis, dehydration, and asthma (2 cases). SAEs seen for the 100mg dose included retinal detachment, acute pancreatitis, appendicitis, dizziness, and seizures. In the placebo arm, SAEs were condition aggravated, appendicitis, meniscal degeneration, and atopic dermatitis. Other safety findings included:

Abrocitinib200mg (N=154)

Abrocitinib100mg (N=156)

Placebo (N=77)

Rate of Serious Adverse Events

3.2%

3.2%

1.9%

Rate of Discontinuation due to an Adverse Event

5.8%

5.8%

9.1%

Additional Details About the JADE MONO-1 Study

The double-blind, parallel group study randomized a total of 387 subjects to abrocitinib 200mg, abrocitinib 100mg, or placebo. Randomization was stratified by baseline disease severity (moderate [IGA=3] and severe [IGA=4] AD) and age (age <18 and 18 years). Eligible subjects completing the 12-week treatment period of the study had the option to enter a long-term extension (LTE) study, B7451015. Subjects discontinuing early from treatment, or who were otherwise ineligible for the LTE study, entered a 4-week follow up period in this study.

For additional information about the JADE MONO-1 study, please visit https://www.clinicaltrials.gov.

Pfizer recently announced positive top-line results from the companion Phase 3 study from the JADE program (JADE MONO-2), suggesting similar positive safety and efficacy results. Additional data for abrocitinib and new findings from the JADE program will be shared in early 2020.

Phase 2b data for abrocitinib were recently published in JAMA Dermatology.

About Abrocitinib

Abrocitinib is an oral small molecule that selectively inhibits Janus kinase (JAK) 1. Inhibition of JAK1 is thought to modulate multiple cytokines involved in pathophysiology of AD, including interleukin (IL)-4, IL-13, IL-31, and interferon gamma.

Abrocitinib received Breakthrough Therapy designation from the U.S. Food and Drug Administration (FDA) for the treatment of patients with moderate to severe AD in February 2018. Breakthrough Therapy designation was initiated as part of the Food and Drug Administration Safety and Innovation Act (FDASIA) signed in 2012. As defined by the FDA, a breakthrough therapy is a drug intended to be used alone or in combination with one or more other drugs to treat a serious or life-threatening disease or condition, and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development. If a drug is designated as a Breakthrough Therapy, the FDA will expedite the development and review of such drug.2

About Atopic Dermatitis

AD is a chronic skin disease characterized by inflammation of the skin and skin barrier defects.3,4 Lesions of AD are characterized by erythema (redness), itching, induration (hardening)/papulation (formulation of papules), and oozing/crusting.3,4

AD is one of the most common, chronic, relapsing childhood dermatoses, affecting up to 10% of adults and up to 20% of children worldwide.5,6

About Pfizers Immunokinase Inhibitor Leadership

The JAK pathways are believed to play an important role in inflammatory processes as they are involved in signaling for over 50 cytokines and growth factors, many of which drive immune-mediated conditions.7 JAK inhibition may offer patients with these conditions a potential new advanced treatment option.8

Pfizers leading JAK biology and chemistry expertise from years of JAK research experience, has enabled the company to take a different R&D approach, resulting in the broadest immunokinase inhibitor pipeline. Instead of studying a single molecule for all its potential uses, where it may not be optimal for some, Pfizers candidates are purposefully matched to the conditions where we believe they have the greatest potential to, if approved, address unmet need. Pfizer has five unique immunokinase inhibitors in late-stage clinical trials for the potential treatment of nine immune-mediated diseases:

Pfizer Inc.: Breakthroughs that Change Patients Lives

At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 150 years, we have worked to make a difference for all who rely on us. We routinely post information that may be important to investors on our website at http://www.pfizer.com. In addition, to learn more, please visit us on http://www.pfizer.com and follow us on Twitter at @Pfizer and @Pfizer_News, LinkedIn, YouTube and like us on Facebook at Facebook.com/Pfizer.

DISCLOSURE NOTICE: The information contained in this release is as of October 12, 2019. Pfizer assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments.

This release contains forward-looking information about a product candidate, abrocitinib, and Pfizers ongoing investigational programs in kinase inhibitor therapies, including their potential benefits, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for our clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when drug applications may be filed in any jurisdictions for any potential indication for abrocitinib or any other investigational kinase inhibitor therapies; whether and when any such applications may be approved by regulatory authorities, which will depend on myriad factors, including making a determination as to whether the product's benefits outweigh its known risks and determination of the product's efficacy and, if approved, whether abrocitinib or any such other investigational kinase inhibitor therapies will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of abrocitinib or any other investigational kinase inhibitor therapies; and competitive developments.

A further description of risks and uncertainties can be found in Pfizers Annual Report on Form 10-K for the fiscal year ended December 31, 2018 and in its subsequent reports on Form 10-Q, including in the sections thereof captioned Risk Factors and Forward-Looking Information and Factors That May Affect Future Results, as well as in its subsequent reports on Form 8-K, all of which are filed with the U.S. Securities and Exchange Commission and available at http://www.sec.gov and http://www.pfizer.com.

______________________________

1 Simpson E, Sinclair R, Forman S et al. Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: Results From the Phase 3, JADE MONO-1 Study. Oral presentation at the 28th Congress of the European Academy of Dermatology and Venereology (EADV), October 9-13, 2019, Madrid, Spain2 U.S. Food and Drug Administration. Fact Sheet: Breakthrough Therapies at https://www.fda.gov/RegulatoryInformation/LawsEnforcedbyFDA/SignificantA... (link is external) accessed on August 16, 2019.3 Hanifin JM, Reed ML. A population-based survey of eczema in the United States. Dermatitis. 2007;18(2):82-91.4 Bieber T. Atopic dermatitis. Dermatology. 2012;1(3):203-217.5 Oszukowska M, Michalak I, Gutfreund K, et al. Role of primary and secondary prevention in atopic dermatitis. Postep Derm Alergol. 2015:32(6):409-420.6 Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015;66(suppl 1):8-16.7 Banerjee, S, Biehl, A, Gadina, M et al. JAKSTAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects. Drugs. 2017;77: 521. https://doi.org/10.1007/s40265-017-0701-9.8 Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, et al. Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition. ACS Chem Biol. 2016;11(12):344251. doi:10.1021/acschembio.6b00677.

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Eating Fish in Early Childhood Even Just Once a Week Reduces Risk of Disease – SciTechDaily

Posted: at 12:47 pm

By Steinar Brandslet, Norwegian University of Science and TechnologyOctober 7, 2019

It seems that eating all types of fish provides a health benefit, not just fatty fish.

Children should be introduced to fish or cod liver oil early in life, from when they are about a year old. Thats because children who consume fish early on show significantly reduced occurrences of eczema, wheezing and asthma at age six, as reported by their parents.

The reduction ranges from 28 to 40 percent fewer occurrences for the various conditions.

We compared children who ate fish at least once a week until they were two years old with children who consumed less fish than that, says associate professor and first author Torbjrn ien in NTNUs Department of Public Health and Nursing.

Researchers from St. Olavs hospital and NTNU conducted the study, which was published in MDPI on August 21, 2019.

The baseline for the study were figures from the pediatric allergy survey Prevention of Allergy among Children in Trondheim that started in 2000. Data from more than 4 000 families contributed to these new analyses, which investigated the relationship between the mothers or childs fish intake and the childs development of eczema, asthma and hay fever.

All of these health conditions have increased sharply in Norway since the 1950s. They have been linked to various changes in our lifestyle, including that the population as a whole is eating less fish.

It seems that eating all types of fish provides a health benefit, not just fatty fish, says Melanie Rae Simpson, the senior author and a postdoctoral fellow at the Department of Public Health and Nursing.

The authors have also taken into account other factors that may be involved, such as socio-economic status.

One conclusion from the study is that we should increase childrens fish intake in the first year of life to have a preventive effect against eczema and asthma.

It could be that children from some social groups such as having parents with higher education or high incomes have health advantages regardless, due to multiple factors.

Perhaps these children simply have more fish in their diets, and the health benefits arent due exclusively to their fish intake, but to several other influencing factors as well. The research team did what they could to account for these possible factors.

In line with previous meta-analyses of several studies, we found that consuming fish at the age of one year seems to reduce the risk of eczema, asthma and wheezing at the age of six. This is more significant than the mothers intake of fish and cod liver oil during pregnancy and breastfeeding or the childs intake at two years, which do not appear to have the same protective effect, says ien.

One conclusion from the study is that we should increase childrens fish intake in the first year of life to have a preventive effect against eczema and asthma.

Reference: Fish Consumption at One Year of Age Reduces the Risk of Eczema, Asthma and Wheeze at Six Years of Age by Torbjrn ien, Astrid Schjelvaag, Ola Storr, Roar Johnsen and Melanie Rae Simpson, 21 August 2019, MDPI.DOI: 10.3390/nu11091969

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More Than Food: 4 Breast Milk Uses Other Than For Feeding Babies – International Business Times

Posted: at 12:47 pm

When theres an oversupply of breast milk, several mothers from Hong Kong have found a way to put the excess supply to good use. Breast milk can be used as an eczema treatment, face mask, plant fertilizer, and even as jewelry.

Many successful breastfeeding moms attested to the abundance of milk. Since this milk holds a host of nutrients, they have devised ways to put them to good use.

Eczema Treatment

As per South China Morning Posts report, a mother from Hong Kong used breast milk to treat the eczema of her 2-month-old baby. She mixed 180ml of breast milk to her babys bath and found visible improvements on her babys skin after 1 week. Aside from this, the breast milk also made her babys skin super soft.

Mother finds other uses of breastmilk. Photo: Satyatiwari - Pixabay

Face Mask

Another mom who found a way how to use her excess breast milk was Serena Eze. As a businesswoman, she would often travel far from home, away from her 3-month-old baby. To keep breastfeeding him, she would pump milk while on business trips. Due to the abundant supply, she would use it as a face mask and body lotion. Mixing it with essential oils and using the solution for 6 months gave her smooth skin.

Plant Fertilizer

Another inspiring mom, Jade Poon, followed the suggestion of her friend to use breast milk for her plants. This came after she posted on Instagram that she was giving a milk bath to her baby, where she adds breast milk to help treat her sons cradle cap. Her friend then suggested that she make use of the milk to nourish her plants. So instead of simply pouring out the water into the drain, she used it to water her plants. The result was amazing. Her dying plants got the nourishment they needed and started becoming healthy.

Jewelry

Some jewelers in Hong Kong have found a way to preserve breast milk and use it as a keepsake for doting moms. One mom preserved her milk and had it made as a trinket. She would have this as a keepsake that could last her and her family a lifetime.

These other uses of breast milk simply show that moms with an oversupply of breast milk must not worry or be stressed. There are other breast milk uses that can certainly benefit not just moms, but also the whole family.

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More Than Food: 4 Breast Milk Uses Other Than For Feeding Babies - International Business Times

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Graphic pictures reveal the horror of eczema sufferer ‘skinned alive … – The Sun

Posted: August 25, 2017 at 3:38 am

ANartist suffered withdrawal symptoms that left her looking like a burns victim and in too much pain to wear clothes after becoming addicted to steroid cream for eczema.

Juli-Anne Coward has spent decades battling topical steroid cream withdrawal (TSW), also known as red skin syndrome, which has caused agonising flare-ups, sore, cracked and peeling skin every time she tried to wean herself off the creams.

PA Real Life

PA Real Life

At its worst Juli-Anne, from Leominster in Herefordshire, said her entire body was covered in raw patches and oozing boils.

But now she has weaned herself off the creams for good.

She said: The longer I am without them, the better I become.

Im definitely seeing progress. I managed a four-mile walk the other day, which is something I havent done in years.

When I first came off them, my body went through hell but I finally feel like Ive turned a corner.

Juli-Anne, 50, was first diagnosed with eczema when she was just three months old and was prescribed a topical steroid cream to calm her itchy skin.

PA Real Life

Throughout her childhood she was plagued by illness and when she was nine had an allergic reaction to penicillin which caused a build-up of fluid in her lungs.

Medics prescribed a six-month course of cortisoneinjections a type of steroid hormone to help her regain her strength but as soon as they stopped her skin went completely haywire.

My eczema went absolutely crazy, and I developed the worst acne youve ever seen, she recalled.

The spots were almost like boils far beyond typical teenage blemishes. Theyd crack and bleed.

I had one on my leg which was so painful, I couldnt even put my foot down.

My confidence was absolutely gone. I hated PE at school, hated showing off my legs. I missed out on a lot.

PA Real Life

PA Real Life

By the time she reached her 20s, Juli-Anne was using a low dose steroid cream every day.

It cleared her skin and, slowly, her self-esteem began to improve.

But if she ran out, or forgot to apply it, her skin would flare up again.

She said: I lived in fear of running out of cream. I could never go anywhere impromptu just in case.

It almost felt like an addiction. If I didnt apply it, my skin would start to burn.

The only way I can describe it to people is that it feels like my clothes are made of nettles and full of wasps.

In her 30s Juli-Anne had a particularly bad reaction after doctors suggested she try a cream commonly used to treat scabies.

Her skin began to shed, peel and bleed, to the point where it was too painful to even wear clothes, leaving her housebound.

PA Real Life

PA Real Life

PA Real Life

Over the next few years Juli-Anne saw various doctors but none seemed to be able to offer a permanent solution to her problem.

In 2016 she decided to research her problem online and came across an online support group called ITSAN the international topical steroid addiction network.

Reading through posts, she became convinced that she, too, was suffering from the condition.

She recalled: It was really emotional. I sobbed and sobbed, because I couldnt believe this was happening to me.

I was terrified at the prospect of what was to come, too, but I knew I had to come off the creams to stop this once and for all.

Red Skin Syndrome, also known as Topical Steroid Addiction or Topical Steroid Withdrawal, is a condition that can arise from the use of topical steroids to treat a skin problem, such as eczema.

RSScan also arise from topical steroid use in individuals with no prior skin condition; such as with cosmetic use for skin bleaching or to treat acne, or in the case of caregivers who neglect to wash their hands after applying topical steroids on someone else.

RSS is characterised by red, itchy, burning skin that can appear after ceasing topical steroid treatments, or even between treatments.

Symptoms:

These can fall into two categories - those that appear while using creams and those that appear when not.

Treatment:

In order to treat the condition, the use of steroid creams must be stopped.

The condition resolves over time, but no medications or methods of treatment have been proven to speed up the healing process.

Source: Itsan - the red skin syndrome support group

After slowly lowering her dose, Juli-Anne stopped using steroid creams for good in September 2016.

At first her skin was in agony but over time she slowly began to improve.

Juli-Anne still wears her clothes inside out so the seams dont irritate her and wraps her skin in bandages every day to protect it.

But she sheds far less than she used to and her skin does not weep as much.

PA Real Life

Juli-Anne, who has been with her partner Carolyn, 54, for 20 years, also uses gentle, natural products on her skin instead of soaps that can be harsh on skin conditions like eczema.

Around two weeks ago she was also told by doctors that her health woes have caused osteoporosis, so shes taking calcium and vitamin D to help protect her bones.

She said: I want to say to others that I understand coming off steroid creams is scary, but support is out there.

Arm yourself with as much knowledge as you can, listen to your body and do whats right for you and your skin.

We pay for your stories! Do you have a story for The Sun Online news team? Email us attips@the-sun.co.ukor call 0207 782 4368

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When eczema gets you banned from driving a rideshare – Malay Mail Online

Posted: August 22, 2017 at 11:30 pm

AUGUST 23 Imagine being plagued with a constant itch, to the point you often find yourself scratching yourself absentmindedly or even in your sleep.

Welcome to the life of someone with eczema. My friend has severe eczema to the point he scratches a lot and has scabs all over his body. While it looks unsightly, it isnt actually contagious.

Just this week, however, one of his rideshare passengers (hes currently a fulltime rideshare driver) reported him to the service and he was suspended just because his skin scared people.

There isnt actually one kind of eczema its the common name given to a group of conditions that can cause skin to become itchy and inflamed. While many people can manage the condition with the appropriate treatments, there are some who find living with it a struggle.

Eczema can easily flare up without warning triggers can include a change of diet, stress, a change in weather, exposure to allergens.

What saddens me is that isnt the first time my friend had his driver status revoked it was the second time. Despite reinstating his account previously after explaining himself and presenting a doctors letter, said service suspended his account again this time without letting him explain himself.

When asked why he was even booted out of the system before being allowed to plead his case, he was informed it was to apparently to give his condition time to recover.

That is ridiculous. Eczema doesnt just clear up on a whim. While people with mild eczema might get some symptom relief with topical creams and medications, people with severe eczema arent as lucky.

There is no magic cure for eczema; what might work for one person might not work for another. My friend also happens to be allergic to quite a few things including seafood and cat dander, which means he relies a lot on antihistamines. But antihistamines also suppress immune reactions, which brings about a whole host of reactions.

Believe me, my friend has tried pretty much anything and everything but his unique set of health issues (beside eczema) make things very hard. Its very likely hell have to rely on medication for the rest of his life.

So before you instinctively jerk away from someone with what you might think is some communicable skin disease, perhaps ask. It could very well just be eczema, complications from allergies or just a bad rash.

In the meantime my poor friend is going to lose his current livelihood just because a passenger couldnt be bothered to ask why his skin was raw and peeling. Life is unfair like that but heres hoping he gets his account back and people would exercise more compassion.

* This is the personal opinion of the columnist.

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Doctor: Eczema medications for children could have long-term side effects – WTSP 10 News

Posted: August 20, 2017 at 5:49 pm

A doctor says children using the skin medication for eczema may have problems later.

Shannon Valladolid, WTSP 11:36 PM. EDT August 19, 2017

Eczema causes the skin to become inflamed.

Kids can have a lot to deal with. School, sports, bullies, the list goes on.

But imagine also dealing with this as well: severe eczema.

Five-year-old Allison and 11-year-old Imaan may be different ages, but they have one thing in common.

I have eczema and I can only eat and wear certain things, says Imaan.

One time my friend told me she didn't like the look of my eczema on me, says Allison.

This is what their eczema looked like before getting on medication.

The girls suffer from eczema.

Both girls said they felt excruciating pain.

I got hospitalized twice. Even when I took a shower, every time water went on me it hurt and there was cuts everywhere, says Imaan.

Dr. Seth Forman with Forward Clinical Trials has been treating the girls for their skin condition.

But while they're breathing a sigh of relief now, Forman says these strong medications they're on could have long term side effects.

The medications that are available right now can cause kidney dysfunction, liver toxicity and other effects to the immune system, says Dr. Forman.

Forman conducts many clinical trials on a wide array of skin conditions like rosacea and psoriasis. He's been pushing to change current regulations that limit young children from being a part of these trials.

We need these newer medications to be approved by the FDA and we need more companies to do research with children, he says. So, we can avoid using these medications.

Right now, those newer medications can be used on adults but not children.

So, in the meantime, girls like Allison and Imaan might have to pay the price in the future for clear skin.

RELATED: Local clinical trials may offer more options for psoriasis patients

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Eczema cure? Doing THIS at the gym could treat the debilitating skin condition – Express.co.uk

Posted: August 18, 2017 at 4:48 am

GETTY

It may seem like an irritating side-effect of hot weather, but sweating is essential for helping your body regulate its temperature, preventing you from overheating.

But its benefits may actually extend further for our health.

Research found that it can help clear up your skin naturally.

A 2005 study published in the Journal of Immunology revealed that atopic dermatitis - a type of eczema - may be triggered because sufferers are lacking dermcidin, an antimicrobial peptide, in their sweat.

GETTY

Research has found that sweating helps excrete arsenic, cadmium, lead, and mercury, as well as reduce risk of kidney stones and treat eczema.

Additionally people who sweat more often due to exercise have a lower risk of kidney stones.

This is thought to be because salt is sweated out instead of the kidneys having to process it, potentially risking stone formation.

It can also help you get rid of toxins.

Research published in the Journal of Environmental and Public Health found that it helps excrete arsenic, cadmium, lead, and mercury.

Getty

1 of 9

Kidney stone risk factors

GETTY

A study released last week by the University of Missouri found that high levels of cadmium raise risk of endometrial cancer in women.

Exercise is an easy way to induce sweat, but can also be triggered in environments such as a sauna.

While some sweating is clearly beneficial, perspiring excessively - known as hyperhidrosis - may be a problem.

As well as being embarrassing it can interfere with daily activities.

GETTY

It is an issue that is surprisingly common in the UK.

Indeed, a survey by Odaban found that 54.7 per cent of Britons suffer from heavy sweating.

Im horribly conscious that I need to present a cool, calm and professional voice of reason in the business meeting environment, so I often take a change of clothes, especially shirts, which Ill put on just before I arrive at my destination, said Charles, 55, a finance director who suffers from excessive facial and all-over body sweating.

I reckon its cost me thousands just in replacement or top-up clothes alone.

Then, of course, I have to perform in the meeting. It sounds trivial, but its dominated my working life for as long as I can remember. Not in a good way at all.

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5 All-Natural Remedies To Treat Eczema Without The Doctor – The Alternative Daily (blog)

Posted: August 14, 2017 at 11:46 am

Eczema is a skin condition where a section of the dermis become irritated, inflamed, itchy, flaky and occasionally blistered. It is surprisingly common in infants and children, but it is a problem that afflicts many teenagers and adults too.

There is no sure-fire cure, and eczema sometimes goes away on its own, but there are natural treatment options that can help reduce flare-ups. Here are some important things you need to know about eczema and treating it naturally.

The term basically refers to a variety of rash-like skin conditions. The symptoms of eczema include red, blotchy skin that is inflamed, irritated and itchy. Frequently, a person with the condition will scratch their skin incessantly, which can exacerbate pus-filled sores, flaking and scaly patches.

Scientists believe a number of different factors can cause or contribute to the condition. For example, heredity, allergens, autoimmune disorders, environmental irritants, hormones, stress and temperature can all play a role in precipitating eczema.

A susceptibility to eczema seems to run in families. However, sensitivity to detergents and common allergens can also induce symptoms. Likewise, hormonal changes linked to pregnancy, menstrual cycles and menopause have all been associated with eczema outbreaks too. Here is a list of common culprits:

Eczema is classified In many ways depending on the cause, the location on the body and the specific symptoms. For example, here are some common types of the condition:

Needless to say, the types of eczema can vary widely in terms of etiology and prognosis. However, promoting healthy skin is one of the safest and most effective ways alleviating eczema and restoring your skin to its optimal state. With that in mind, here are five all-natural remedies that will help you cope with the underlying factors that contribute to eczema.

Hempseed oil is a fixture in many body care products including shampoos, body lotions and moisturizers. Thats because the hemp plant is especially rich in omega-3 and omega-6 fatty acids, which are renowned for promoting healthy hair and skin growth.

In particular, omega-3 and omega-6 oils are natural moisturizers that prevent dryness while promoting lipid and collagen growth, which help rejuvenate your damaged dermal layers. In addition, omega-3 and omega-6 act as a natural sunscreen, which helps block harmful UV rays that can damage skin at the cellular level.

Hemp is a close cousin of the marijuana plant. So, its not surprising that Cannabis sativa would contain compounds that are extremely beneficial for the skin too. As it happens, THC and CBD have anti-inflammatory, antioxidant and antimicrobial properties, which promote healthy skin. However, smoking marijuana is not a good way of getting these compounds. Put simply, inhaling any plant-based smoke means breathing in hydrocarbons, which are not conducive to your skins health.

However, cannabis-based topicals such as lotions, creams, tinctures and oil are a terrific way of delivering the benefits of cannabinoids to your skin. Thats because endocannabinoid receptors are dispersed throughout the epidermis. Therefore, when you apply cannabis-based topicals you are delivering natural cannabinoids most notably THC and CBD directly to the endocannabinoid receptors in the skin.

To begin with, THC and CBD are natural anti-inflammatory agents. Therefore, they quickly act to reduce swelling and pus at the cellular level. Second, cannabinoids are potent antimicrobials. Consequently, they naturally combat bacteria, fungi and other microorganisms that can cause skin infections. Finally, THC and CBD are powerful antioxidants. Indeed, cannabinoids contain higher levels of free radical scavengers than vitamins A, C and E. As a result, cannabis-based topicals help counteract genetic damage at the cellular level that diminishes skin health.

In a landmark study on cannabis and skin care, a team of scientists led by Dr. Gerald Weissmann found that cannabis-based topicals promote healthy lipid production, which is critical for regulation of dry skin and counteracting many epidermal disorders.

According to Dr. Weissman, the latest research shows that we may have something in common with the marijuana plant. Just as THC is believed to protect the marijuana plants from pathogens, our own cannabinoids may be necessary for us to maintain healthy skin and to protect us from pathogens.

This view is echoed by Phytecs, a consortium of scientists investigating how foods and other natural substances support endocannabinoid health. Summing up their research they wrote, Endocannabinoids regulate skin inflammation, oil production and even play a role in unwanted hair growth. Skin care products that target the endocannabinoid system are likely to be a fundamental element of next-generation cosmetic treatments.

Aloe vera gel has been used as a skin care remedy for centuries. It has most often been used to treat sunburn and psoriasis, but there is a lot of anecdotal evidence that it can help treat eczema too.

In particular, when applied topically to the skin, aloe vera gel helps deliver a cooling and soothing sensation, which can reduce the urge to itch. In addition, compounds in aloe vera gel have both hydrating and anti-inflammatory properties. The former creates a humectant effect, which may counteract the dryness and flakiness of the outermost epidermal barrier that is often associated with eczema.

The scientific evidence that aloe vera can treat eczema still remains scant, but it has been used safely for centuries as a topical remedy to relieve symptoms associated with dry, broken or irritated skin.

Coconut oil is rich in lipids. Therefore, it helps fill in intercellular space in your skin, which can lead to moisture loss. Coconut oil is especially well-suited to treating eczema for several other reasons too. To begin with, it has immuno-modulating properties. Therefore, it can detoxify histamines, which contributes to skin inflammation, but without any of the negative side-effects associated with cortisone creams or ointments.

In addition, coconut oil is rich in fatty acids that strengthen the connective tissue in your skin. Finally, coconut oil is rich in lauric acid, which helps the skin resist bacteria, fungi and other microorganisms.

Chamomile tea is known to relax the mind, but what about your skin? In fact, chamomile contains traces of a natural alcohol known as bisabolol which has antimicrobial anti-inflammatory properties.

To soothe your skin, try taking a chamomile tea bath. Youll need four chamomile tea bags (or four teaspoons of dried chamomile tied inside a cheesecloth bag). Run warm water from your bathtub faucet for ten to fifteen minutes over chamomile tea. Next, steep yourself in this calming brew. The natural compounds in chamomile should reduce itchiness, fight germs and lessen inflammation too.

Theres no cure-all for eczema that works for everybody all the time. Thats because eczema is a complex condition with many contributing factors. However, there are a number of all-natural remedies that can help you alleviate eczema symptoms while promoting healthier skin. Hopefully, by understanding how these natural compounds work you can discover the ones that work best for you.

Scott OReilly

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