Category Archives: Transhuman News

In patients with psoriasis and psoriatic disease, metabolic inflammation is a cause of comorbid depression, according to new research.

A research article1 reported that specific inflammatory patterns within IL-6, IL-8, IL-23, IL-17 family cytokines, and tumor necrosis factor (TNF) can cause neuroinflammation, ultimately leading to anxiety and/or depressive behavior or depression in patients with psoriatic disease. According to authors, prior knowledge of psoriasis and comorbid depression linked burden of disease, psychological stress, and stigmatization to the origins of depression.

Authors noted that non-cutaneous diseases such as diabetes, heart failure, and hypertension were first identified as comorbidities of psoriasis in 1995, with cardio-metabolic consequences related to psoriatic disease being more thoroughly understood over time. Risk of myocardial infarction, for example, was previously found to be significantly higher in patients with psoriasis than in members of the general population.

Other conditions such as dyslipidemia and endothelial dysfunction were also linked to psoriatic disease. Like depression, article authors noted that both comorbid conditions are linked to inflammation.

In western countries, authors note that 1 in 5 people with psoriatic disease, as much as 20%, also experience depression. Previous studies have also demonstrated that rates of depression are higher in patients with psoriatic conditions than in the general population.

Citing recent brain structure research,2 authors described research demonstrating increased right precuneus thickness in people with psoriasis, only in cases where depression was present. Additionally, further research3 demonstrated a positive correlation between psoriasis area and severity index (PASI) and the Zung self-rating depression scale (SDS) in cases of comorbid depression and psoriasis.

Considering that depression is an inflammatory condition with neuroinflammatory events with a similar signature as in the major domains of psoriatic disease, people with psoriasis-associated depression are no longer responsible for their perceived lack of coping with psychological threads, articleauthors wrote. In the practical management of people with psoriatic disease, screening for depression by using simple clinical questions or respective tools needs to be implemented.

References

See the rest here:
Metabolic Inflammation Contributes to Depression in Psoriatic Disease - Dermatology Times

In an interview with HCPLive Rheumatology, Soumya Chakravarty, MD, PhD, FACP, FACR, Senior Director, Strategic Lead, Janssen Rheumatology, and Daphne Chan, PhD, Head of Dermatology Medical Affairs, Janssen, discussed Janssens commitment to diversity, equity, and inclusion for patients with psoriatic disease.

It has been a fantastic opportunity to emphasize our dedication to advancing care for patients with immune-mediated diseases, especially those with psoriatic disease who belong to communities of color, Chakravarty emphasized. The determination platform we discussed is just one of many ongoing efforts, where we collaborate with various partners to develop specific solutions. It's important to note that this is just the beginning.

Their efforts are accompanied by extensive data generation in patients of color and the creation of a diverse workforce. They strive to deliver culturally competent care and promote progress in this area.

At Janssen, they have undertaken an extensive analysis of the dermatology and rheumatology landscapes to identify unmet needs so they can take meaningful actions as an industry leader and partner. They make an effort to acknowledge the problems the world faces and are realistic about what they can address. Therefore, they focus on the areas where they can make a difference.

Regarding the VISIBLE study, Chan emphasized that simply conducting the study opens doors to demonstrating how it is possible and why it should become the new standard in trial conduct.

Initially, we were apprehensive and doubted whether it could be done, Chan stated. However, I am pleased to report that even taking that first step has yielded tremendous results and rewards. We surprised ourselves by completing the trial's enrollment 7 times faster than projected, concluding 6 months ahead of schedule.

With the trial recruiting so quickly, they expect to have results available sometime next year.

We will be delighted to re-engage in a conversation about the results and what we are learning about people of color living with psoriasis and psoriatic arthritis, Chan emphasized. This experience sets a new chapter for inclusive research and medical practice, defining how it should be in the future.

This transcript was edited for clarity.

Read the original here:
Encouraging Diversity and Inclusion for Patients With Psoriatic ... - MD Magazine

Expanding Ethnic Hair Care

In this months Cosmetic Conundrums column, Zoe Diana Draelos, MD, discusses solutions for ethnic and Afro-textured hair care.

A recent study supports a degree of correlation between trough serum concentration of infliximab and clinical response to infliximab in patients with the condition.

Researchers analyzed dermatoses associated with obesity and insulin resistance in pediatric patients.

Renata Block, MMS, PA-C, spearheaded a skin cancer screening event for veterans in her hometown.

As many as 1 in 5 patients with psoriasis experience depression as a comorbidity.

Topline results for the topical sodium channel blocker are expected in 2024.

The adalimumab biosimilar will be commercially available in the US starting July 1, 2023.

The first-of-a-kind product uses a topically applied small peptide fluorescent dye and handheld imager to non-invasively detect a biomarker of early tissue changes.

In part 3 of this Frontline Forum series, John M. Strasswimmer, MD, PhD; Andrew H. Weinstein, MD; Neal Bhatia, MD; Laura Ferris, MD; and Aaron S. Farberg, MD, discuss solutions for managing and treating patients with basal cell carcinoma.

New research into the diseases pathogenesis may inform future treatment options.

Cream containing epigallocatechin gallate (EGCG) or EGCG combined with L-carnitine yielded a greater anti-sebum effect.

If you werent able to attend SCALE 2023 or want to review the latest data, our full recap has you covered.

In this weeks Pointers with Portela, the 208SkinDoc gives his best product recommendations for Mother's Day gifts.

The autosomal recessive disorder is primarily caused by mutations in the TGM5 gene and less frequently in the CSTA gene.

While receiving checkpoint inhibitor therapy, patients with advanced melanoma benefitted from a telehealth exercise program.

Click here to answer this week's poll.

The JAK inhibitor demonstrated promising efficacy and safety.

Yuflyma will be available to US patients in July 2023.

The clinical and histologic subtypes encompassed by granulomatous dermatitis include palisaded neutrophilic granulomatous dermatitis and interstitial granulomatous dermatitis. This review compares the features of each cutaneous eruption.

This week's edition of the Mainstream Patient features stories about facial balancing, eyelid surgery 101, dermatologist-recommended sunscreen sticks, and more.

In this months Finance & Practice Management column, we illustrate the importance of developing and maintaining a budget for physicians at all stages of their careers.

Coastal regions require environmentally-protective sun protection measures and best practices.

In patients with high levels of VEGF-A and more severe psoriasis, downregulation of blood vessel area is more abrupt.

Read more:
The Weekly Roundup: May 22-26 - Dermatology Times

[Vancouver, Canada, 16-05-2023] Emergen Research, a leading provider of market research solutions, is thrilled to announce the release of its highly anticipated collection of comprehensive market research content. This innovative offering aims to empower businesses across industries with valuable insights and data-driven strategies to drive growth and success.

In todays competitive marketplace, staying ahead of the curve is essential for businesses of all sizes. Understanding consumer behavior, market trends, and emerging opportunities is crucial for making informed decisions and developing effective strategies. Emergen Research recognizes this need and has invested significant resources in developing a cutting-edge market research content library.

The newly launched Pediatric Psoriasis market research content is meticulously crafted by industry experts, leveraging extensive data analysis, and a deep understanding of various markets. This rich collection includes in-depth reports, whitepapers, case studies, trend analyses, and industry insights covering a wide range of sectors, including but not limited to technology, healthcare, finance, consumer goods, and manufacturing.

Request Free Sample Copy (To Understand the Complete Structure of this Report [Summary + TOC]) @ https://www.emergenresearch.com/request-sample/52

The global pediatric psoriasis market was valued at USD 9.76 billion in 2019 and is expected to reach USD 21.38 billion by the year 2027, at a CAGR of 10.3%. The global Pediatric psoriasis market is growing at a significant pace owing to the growing demand for therapy for diseases such as pediatric psoriasis, favorable government initiatives followed by intensive product development. Considering the factors such as considering the physical development and rate of cutaneous absorption, treating a child with psoriasis has been a huge challenge. With the advent of technology, research has contributed significantly to the various development of treatment for the disease across the globe. Psoriasis is a life-long devitalizing disease that has a significant impact both emotionally and physically including other aspects of life of children. The prolonged sun exposure makes it more demanding while considering phototherapy in children for the rest of their life. Therefore, long-term treatment of psoriasis, with phototherapy or drugs, needs critical evaluation.

Competitive Landscape:

The latest study provides an insightful analysis of the broad competitive landscape of the global 777 market, emphasizing the key market rivals and their company profiles. A wide array of strategic initiatives, such as new business deals, mergers & acquisitions, collaborations, joint ventures, technological upgradation, and recent product launches, undertaken by these companies has been discussed in the report.

AbbVie Inc.; Amgen Inc.; Johnson & Johnson; Novartis AG; Eli Lilly & Company; AstraZeneca; Celgene Corporation; UCB; and Merck, Boehringer Ingelheim and LEO Pharma

Emergen Research is Offering Limited Time Discount (Grab a Copy at Discounted Price Now) @ https://www.emergenresearch.com/request-discount/52

Market Segmentation:

The report bifurcates the Pediatric Psoriasis market on the basis of different product types, applications, end-user industries, and key regions of the world where the market has already established its presence. The report accurately offers insights into the supply-demand ratio and production and consumption volume of each segment.

Our goal at Emergen Research is to empower businesses with the knowledge and insights necessary to make informed decisions and thrive in todays dynamic business landscape. Our market research content is designed to equip professionals and organizations with comprehensive analyses, actionable recommendations, and a competitive edge to achieve their growth objectives.

Custom Requirements can be requested for this Report [Customization Available] @ https://www.emergenresearch.com/request-for-customization/52

Target Audience of the Global Pediatric Psoriasis Market Report:

Key features and benefits of Emergen Researchs market research content include:

Browse Full Report Description + Research Methodology + Table of Content + Infographics@ https://www.emergenresearch.com/industry-report/pediatric-psoriasis-market

About Emergen Research

Emergen Research is a market research and consulting company that provides syndicated research reports, customized research reports, and consulting services. Our solutions purely focus on your purpose to locate, target, and analyze consumer behavior shifts across demographics, across industries, and help clients make smarter business decisions. We offer market intelligence studies ensuring relevant and fact-based research across multiple industries, including Healthcare, Touch Points, Chemicals, Types, and Energy.

Recent Published Reports By Emergen Research:

Autoimmune Disease Diagnostics

Autoimmune Disease Diagnostics Market High Demand, Recent Trends, Future Growth, Industry Analysis, Forecasts Research, Top Manufacturers and Outlook 2032

Autoimmune Disease Diagnostics

Autoimmune Disease Diagnostics

https://apekshapatil.pubpub.org/pub/oofo779k/release/1

Autoimmune Disease Diagnostics

https://vocus.cc/editor/64704793fd89780001510917

Autoimmune Disease Diagnostics

https://app.simplenote.com/p/Zcyhrj

Autoimmune Disease Diagnostics

https://md.picasoft.net/s/N8Nc7GRkT

Autoimmune Disease Diagnostics

https://zybuluo.com/apeksha/note/2531871

Autoimmune Disease Diagnostics

https://calis.delfi.lv/blogs/posts/187203-autoimmune-disease-diagnostics-market-technology-product-scope-demand-busines/lietotajs/300971-apeksha/

Autoimmune Disease Diagnostics

Autoimmune Disease Diagnostics Market Product Scope, Demand, Business Scenario, Trends, Share, Applications, Types and Forecasts 2023 – 2032

Autoimmune Disease Diagnostics

Autoimmune Disease Diagnostics Market Is Highly Growing in Industry with Good Revenue by 2032 | Emergen Research

Contact Us:

Eric Lee

Corporate Sales Specialist

Emergen Research | Web: https://www.emergenresearch.com/

Direct Line: +1 (604) 757-9756

E-mail: sales@emergenresearch.com

See the original post here:
Pediatric Psoriasis Market: A Study of the Industry's Key Applications ... - The Navajo Post

PRESS RELEASE

Published May 29, 2023

By the end of 2022, the market forPhototherapy Lamps Marketis projected to be worth US$ 3.2 Billion, up from US$ 3.0 Billion in 2021. The overall demand for phototherapy lamps is also anticipated to increase at a CAGR of 5.8% between 2022 and 2032, reaching an estimated value of US$ 5.6 Bn by 2032, due to the growing use of phototherapy lamps for treating a variety of medical disorders, including psoriasis and neonatal jaundice.

Based on product, the LED segment dominated the phototherapy lamps market in 2021, accounting for approximately 37.1% of the market, and it is expected to grow at a higher CAGR during the forecast period.

Request for a sample @https://www.futuremarketinsights.com/reports/sample/rep-gb-5834

According to the reports regional insights, North America will continue to dominate the global phototherapy lamps market in terms of revenue throughout the forecast period.

The adoption of phototherapy as a safer treatment option for skin disorders has increased significantly in the US and Canadas healthcare markets.

Consumer lifestyles in North America will continue to increase the prevalence of common skin diseases, which will primarily be treated with phototherapy lamps.

Furthermore, North Americas dominance in the global market has been supported by a robust infrastructure for the adoption of phototherapy lamps.

According to the report, phototherapy lamps sold in the United States and Canada will generate nearly $700 million in revenue in 2017.

Skin care clinics to emerge as the largest end-user of phototherapy lamps

According to the report, hospitals will initially experience high traction in terms of end-users, but skin care clinics are expected to have the highest revenue share in the global market.

Ask from Market Research [emailprotected] https://www.futuremarketinsights.com/ask-question/rep-gb-5834

LED-based phototherapy lamps to register highest sales

According to the study, LED-based phototherapy lamps are the best-selling products on the global market.

The low risk of burns, low cost of production, and ease of installation will continue to drive demand for LED-based phototherapy lamps in the near future.

The LED segment will account for nearly US$ 1.6 billion in revenue in the global phototherapy lamps market by the end of 2026.

According to the study, demand for UV-based phototherapy lamps will be strong, while halogen lamps will lose traction near the end of the forecast period.

Growing effectiveness of phototherapy in psoriasis treatment to drive the sales of phototherapy lamps:

Phototherapy lamps will be primarily used in the treatment of psoriasis due to their applications. Phototherapy lamps sold for the treatment of psoriasis are expected to bring in more than $500 million in 2017.

The use of phototherapy lamps in the treatment of neonatal jaundice is expected to grow at the fastest CAGR of 8.1% during the forecast period.

For more Report Customization, connect with us [emailprotected] https://www.futuremarketinsights.com/customization-available/rep-gb-5834

Leading manufacturers of phototherapy lamps have been profiled in the report. Koninklijke Philips N.V., General Electric Company, Drgerwerk AG & Co. KGaA, Bistos Co. Ltd., TSE SPOL. S. R. O., The Daavlin Company, Fanem Ltda., Herbert Waldmann GmbH & Co. KG, Natus Medical Incorporated, and Schulze & Bohm GmbH are expected to actively partake in the expansion of the global phototherapy lamps market through 2026.

Key Segments:

Product Type

End User

Use promo code >> FMITODAY to get flat 20% discount

Application

Top Related Reports:

Spasticity Treatment Market Single-use Gastroscopes Market Multi-therapy Infusion Pumps Market

About Future Market Insights (FMI)

Future Market Insights, Inc. (ESOMAR certified, Stevie Award recipient market research organization and a member of Greater New York Chamber of Commerce) provides in-depth insights into governing factors elevating the demand in the market. It discloses opportunities that will favor the market growth in various segments on the basis of Source, Application, Sales Channel and End Use over the next 10-years.

Contact Us:

Future Market Insights Inc. Christiana Corporate, 200 Continental Drive, Suite 401, Newark, Delaware 19713, USA T: +1-845-579-5705 For Sales Enquiries:[emailprotected] Website:https://www.futuremarketinsights.com LinkedIn|Twitter|Blogs

The post Phototherapy Lamps Market are set to witness a CAGR of 5.8% totaling a valuation of around US$ 5.6 Billion by 2032 appeared first on Future Market Insights.

The rest is here:
Phototherapy Lamps Market are set to witness a CAGR of 5.8 ... - Digital Journal

Celltrion's corporate logo (Celltrion)

Celltrion said Friday that the company has submitted a marketing authorization application for CT-P43, the company's ustekinumab biosimilar referencing Stelara, to the European Medicines Agency.

Stelara is one of Janssen's top-selling drugs. In 2022, Stelara generated $9.7 billion in revenue, according to a report released by Statista.

The global market for ustekinumab last year was estimated at $17.7 billion, Celltrion added.

Celltrion said its CT-P43, like the reference drug Stelara, can be used to treat patients with psoriasis, psoriatic arthritis, Crohns disease and ulcerative colitis.

Celltrion added it is seeking EMA approval for the same indications that have been labeled for Stelara.

Previously, Celltrion conducted a global phase 3 clinical trial to compare the efficacy and safety of CT-P43 to Stelara in patients with moderate to severe plaque psoriasis.

If it wins approval, Celltrion will look to boost its sales.

"If CT-P43 wins the EMA approval, the company will be able to increase competitiveness in the autoimmune disease therapeutics market, where the company has previously launched treatments such as Remsima, Remsima SC and Yuflyma," Celltrion said.

By Shim Woo-hyun (ws@heraldcorp.com)

See more here:
Celltrion seeks approval for Stelara biosimilar in EU - The Investor

In this HCPLive interview, Peter Marinkovich, MD, associate professor of dermatology at Stanford University School of Medicine, spoke about the US Food and Drug Administration (FDA) approval of beremagene geperpavec (B-VEC) (VYJUVEK) for patients with dystrophic epidermolysis bullosa (DEB).1

Marinkovich had been a primary investigator in the multi-center, randomized, double-blind, placebo-controlled GEM-3 trial sponsored by Krystal Biotech.

The phase 3 trial had met both its primary and secondary endpoints, with B-BEC-treated patients having a substantially greater rate of achieving complete wound healing from DEB than placebo at 3 and 6 months (P <.005).2

Before the PDUFA dates announcement, trial data on 31 DEB patients indicated that around 70% of wounds had closed within 6 months of treatment, including the patient that had the dominant form of DEB.

It's just the the culmination of a number of multi-year effort to develop this topical gene therapy drug, and it's so exciting to actually be able to be in this position to be able to offer something back to the very deserving patient population who does not currently have any approved therapies and who are very much in need, Marinkovich explained.

The treatments PDUFA data had been extended to May 2023 resulting from a regulatory update that the FDA deemed important. Krystal Biotech then submitted its manufacturing information update related to a replaced hardware unit in B-VECs manufacturing process.

This is a vector that's based on the HSV-1 backbone, he said. HSV-1 over its many thousands of years of cohabitation with humans has evolved a way to be able to evade the immune systemAs a gene therapy vector, to have a vector that can evade the immune system, it really makes it much easier to use.

Marinkovich explained the function of the treatment and how it addresses wound healing for DEB patients. He then went into related research in which he had been involved.

Some of the things that we're currently studying are the effects of feedback on mucosal surfaces in addition to the skin, he said. And that was a very promising report of a single patient who's had their eyes treated, and was able to show some improvement in the vision as well as very good safety over multiple applications.

Marinkovich noted that these are all areas that EB patients suffer from and that they could benefit from B-VEC therapy. He concluded with his thoughts on the future for DEB patient options.

I'm super happy about the FDA decision, they also seem to recognize the important need of the EB patients to get a corrective therapy like this one, Marinkovich said. And I feel so happy for the EB patients to be able to have corrective therapy and be able to finally, after all these years, be able to actually start to get some benefit.

The quotes contained here were edited for clarity. For further information about Marinkovichs take on the FDAs approval of B-VEC therapy, view the video above.

View original post here:
Peter Marinkovich, MD: FDA Approval of B-VEC Gene Therapy for ... - MD Magazine

Nick Stucky, MD, PhD, continued his discussion of his teams findings on rates of prescription of oral minoxidil following the publication of an article by The New York Times, noting the biggest implications of the findings.1

Stucky is vice president of research at Truveta, working also as a physician-scientist and bioengineer. Additionally, he is known for being a start-up founder, faculty teaching, and having been research director.

After having described the findings, Stucky in this interview segment first described the studys limitations in general.

One thing is that we get data from our member healthcare systems, so they provide care to a certain population, he explained. We have 17% of the US healthcare daily delivered care within our dataset, so it's quite large. But there are always potential biases if you're not actually surveying the whole US population.

Stucky also added that there may be a skew toward insured patients, for example. He added that there were certain questions by reviewers regarding whether the article led to increased prescribing for all hair loss medications.

And so we added kind of a control armwhich was another hair loss medication that wasn't mentioned in that article, Stucky explained, adding that this group had no changes in prescribing.

He then highlighted some of the biggest implications from his teams findings, noting that they did not know for sure whether the article had a direct impact on the providers or the patients who read the single media publication.

But yes, I mean, I think it definitely says that we're all human, and we all are sort of influenced by our environment, Stucky said. And certainly, this indicates that either practitioners or patients can be profoundly impacted in terms of how they interact with the healthcare system, by a single article.

Additionally, Stucky mentioned that he believes there are other important implications for his teams findings.

I think many providers probably had concerns about whether it was safe, whether there'd be any adverse effects, but those had mostly been put to rest by these handful of studies that have come out, he said. But nobody was aware of them and so by, in this case, a New York Times article, but really any other media that we're consuming, we can learn really valuable (insights).

The interview segments quotes were edited for clarity. For more information on the research described here, view the full video above.

See the article here:
Nick Stucky, MD, Phd: Implications for Media Influence on Minoxidil ... - MD Magazine