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Category Archives: Transhuman News
Dinos' DNA Demise: Genetic Material Has a 521-Year Half-Life
Posted: October 10, 2012 at 7:19 pm
A new analysis confirms the widely held suspicion that DNA from dinosaurs and ancient insects trapped in amber cannot be recovered to make a 'Jurassic Park'-style theme park
By Matt Kaplan and Nature magazine
Palaeogeneticist Morten Allentoft used the bones of extinct moa birds to calculate the half-life of DNA. Image: M. Mhl
Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way...
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From Nature magazine
Few researchers have given credence to claims that samples of dinosaur DNA have survived to the present day, but no one knew just how long it would take for genetic material to fall apart. Now, a study of fossils found in New Zealand is laying the matter to rest and putting paid to hopes of cloning a Tyrannosaurus rex.
After cell death, enzymes start to break down the bonds between the nucleotides that form the backbone of DNA, and micro-organisms speed the decay. In the long run, however, reactions with water are thought to be responsible for most bond degradation. Groundwater is almost ubiquitous, so DNA in buried bone samples should, in theory, degrade at a set rate.
Determining that rate has been difficult because it is rare to find large sets of DNA-containing fossils with which to make meaningful comparisons. To make matters worse, variable environmental conditions such as temperature, degree of microbial attack and oxygenation alter the speed of the decay process.
But palaeogeneticists led by Morten Allentoft at the University of Copenhagen and Michael Bunce at Murdoch University in Perth, Australia, examined 158 DNA-containing leg bones belonging to three species of extinct giant birds called moa. The bones, which were between 600 and 8,000 years old, had been recovered from three sites within 5 kilometres of each other, with nearly identical preservation conditions including a temperature of 13.1 C. The findings are published today in Proceedings of the Royal Society B.
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Dinos' DNA Demise: Genetic Material Has a 521-Year Half-Life
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DNA dating study kills off Jurassic Park
Posted: at 7:19 pm
Reconstructing dinosaurs from ancient DNA has been dealt a blow with a new study finding genetic material can only last 1 million years.
An international team of researchers reached the finding after analysing DNA extracted from bones of the extinct New Zealand moa.
They found that while short fragments of DNA could possibly survive up to 1 million years, sequences of 30 base pairs or more would only have a half-life of around 158,000 years under certain conditions.
Lead author Dr Morten Allentoft from Murdoch University's Ancient DNA lab in Perth says their results contradict earlier studies which claimed to have extracted DNA fragments several hundred base pairs long from dinosaur bones and preserved insects, claims which underpinned the storyline of the 1993 movieJurassic Park.
"What we show here with the decay rate of DNA is that this is never going to be possible," Dr Allentoft said.
"It may be that you can have extremely short fragments of DNA, only a few base pairs that persist for maybe a million years, maybe even longer."
Dr Allentoft says the earlier findings may have been due to contamination with human DNA.
Rate of decay
The latest study, published in the Proceedings of the Royal Society B, also establishes a DNA decay rate which could help identify specimens likely to yield useful genetic material.
It might also one day enable DNA to be used to date bones and teeth or even be used for forensic investigation of human remains.
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DNA dating study kills off Jurassic Park
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DNA Brands to Re-Brand and Undertake New Marketing Campaign
Posted: at 7:19 pm
BOCA RATON, FL--(Marketwire - Oct 10, 2012) - DNA Brands, Inc. ( OTCBB : DNAX ), makers of the great tasting DNA Energy Drink, a favorite of the action sports community and its enthusiastic followers, announced today it is re-branding its entire line of DNA Energy Drinks to be able to reach a greater portion of the ever-growing energy drink market.
Darren Marks, President of DNA Brand, Inc., stated, "The one comment we hear over and over is that energy drinks don't taste good. We were previously selected as the best tasting energy drink by an independent international World Beverage Competition. We intend to get this fact out to the energy drink consumer. Our current graphics were primarily geared to the action sports community. Although we will continue to pursue these same customers, we will do it with new and innovative products geared to better communicate the brand's core identity while appealing to a much broader demographic; active consumers from every walk of life. We are confident that this rebranding will enable us to better position ourselves in a category that continues to re-invent itself and grow at a rapid pace. Energy drink sales increased 17.2% in 2011, the highest growth rate since 2007." In conjunction with the re-branding, Jeff Jonke has been promoted to the Company's Executive Vice-President and General Manger. He will be the driving force behind this new and exciting time for DNA Brands, Inc.
About DNA Brands, Inc.
DNA BRANDS, makers of DNA Energy Drink, the award-winning, best-tasting energy drink at the 2010 World Beverage Competition, is a proprietary blend of quality ingredients in four flavors: Citrus, Lemon Lime, Sugar Free Citrus and CRANRAZBERRY. DNA can be found at independent retailers throughout the state of Florida, as well as national retailers including Walgreens, Race Trac and Circle K. Distribution is primarily through Grass Roots Beverage, the Company's wholly owned subsidiary and select Miller and Anheuser-Bush distributors in select markets.
DNA is a proud sponsor of many action sport teams. True to its action sports roots, DNA BRANDS, INC. has earned national recognition through its sponsorship of the DNA Energy Drink/Jeff Ward Racing team where it competes on a world-class level in Supercross and Motocross, reaching millions of fans. DNA Energy Drink can also be found in other action sports such as Surfing, BMX, Wakeboarding and Skateboarding and its athletes are recognized stars in their own right.
For more information about DNA Energy Drink, its athletes and sponsorships, please visit http://www.dnabrandsusa.com or contact: Darren M. Marks, President (954) 970 3826 darren@dnaenergydrink.com
Safe Harbor Forward-Looking Statements
To the extent that statements in this press release are not strictly historical, including statements as to revenue projections, business strategy, outlook, objectives, future milestones, plans, intentions, goals, future financial conditions, future collaboration agreements, the success of the Company's development, events conditioned on stockholder or other approval, or otherwise as to future events, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements contained in this release are subject to certain risks and uncertainties that could cause actual results to differ materially from the statements made.
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DNA Brands to Re-Brand and Undertake New Marketing Campaign
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'Jurassic Park' May Be Impossible, But Dino DNA Lasts Longer Than Thought
Posted: at 7:19 pm
In "Jurassic Park," scientists extract 80-million-year-old dino DNA from the bellies of mosquitoes trapped in amber. Researchers may never be able to extract genetic material that old and bring a T. rex back to life, but a new study suggests DNA can survive in fossils longer than previously believed.
The oldest DNA samples ever recovered are from insects and plants in ice cores in Greenland up to 800,000 years old. But researchers had not been able to determine the oldest possible DNA they could get from the fossil record because DNA's rate of decay had remained a mystery.
Now scientists in Australia report they've been able to estimate this rate based on a comparison of DNA from 158 fossilized leg bones from three species of the moa, an extinct group of flightless birds that once lived in New Zealand. The bones date between 600 and 8,000 years old and importantly all come from the same region.
Temperatures, oxygenation and other environmental factors make it difficult to detect a basic rate of degradation, researcher Mike Bunce, from Murdoch University's Ancient DNA lab in Perth, explained in a statement.
"The moa bones however have allowed us to study the comparative DNA degradation because they come from different ages from a region where they have all experienced the same environmental conditions," Bunce said.
Based on this study, Bunce and his team put DNA's half-life at 521 years, meaning half of the DNA bonds would be broken down 521 years after death, and half of the remaining bonds would be decayed another 521 years after that, and so on. This rate is 400 times slower than simulation experiments predicted, the researchers said, and it would mean that under ideal conditions, all the DNA bonds would be completely destroyed in bone after about 6.8 million years.
"If the decay rate is accurate then we predict that DNA fragments of sufficient length will preserve in frozen fossil bone of around one million years in age," Bunce said.
But he cautioned that more research is needed to examine the other variables in the breakdown of DNA.
"Other factors that impact on DNA preservation include storage time following excavation, soil chemistry and even the time of year when the animal died," Bunce said in a statement. "We hope to refine predictions of DNA survival by more accurately mapping how DNA fragments decay across the globe."
The study was published Oct. 10 in the journal Proceedings of the Royal Society B.
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'Jurassic Park' May Be Impossible, But Dino DNA Lasts Longer Than Thought
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Mount Sinai School of Medicine Offers First-Ever Course with Whole Genome Sequencing
Posted: at 7:19 pm
Course Provides Opportunity for Students to Sequence, Analyze and Interpret Their Own Personal Genome Using Cutting-Edge Techniques
(PRWEB) October 08, 2012
The elective course, titled Practical Analysis of Your Personal Genome, is designed to address a gap in todays medical and graduate school education: to teach students how to understand and apply the wealth of information now available via whole genome sequencing, a laboratory process that reveals the unique genomic profile of each individual performed in the Genomics Core Facility at Mount Sinai. This course is offered through the Genetics and Genomic Sciences training area within the Graduate School of Biological Sciences.
Specifically, whole genome sequencing refers to full elucidation of an organisms DNA, which involves more than 3 billion nucleotide bases known as A,T, C, and G. It is an important part of a new era in modern medicinecalled precision medicinewhere precise knowledge of the molecular mechanism behind a patients condition would ultimately allow physicians to determine more individualized care. Recent technological advances have substantially lowered the cost of whole genome sequencing to where it can soon be applied in routine clinical care.
For precision medicine to become a routine in the medical clinic, we need to train the next great generation of physicians to harness sequencing-driven medical genetics, explained Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of Mount Sinai School of Medicine and the Executive Vice President for Academic Affairs of The Mount Sinai Medical Center. We believe that an approach tailored to each individual patients diagnosis and treatment, informed by genomic information, will provide dramatic improvements in the quality of care. Practical Analysis of Your Personal Genome reflects Mount Sinais commitment to revolutionize the diagnosis and treatment of disease through the application of genomic information.
Andrew Kasarskis, PhD, Vice Chair, Department of Genetics and Genomic Sciences, said, "Unlike other courses that use commercial services to provide students with only a small portion of their genetic data, we decided to offer students in the course the unprecedented opportunity to do whole genome sequencing to view, analyze and interpret their entire genome." Dr. Kasarskis is also Co-Director, Mount Sinai Institute for Genomics and Multiscale Biology at Mount Sinai.
Students have the option to either sequence their own personal genome or that of an anonymous reference genome. When analyzing a complete genome, students will find greater than 4 million variants, many with known clinical significance, yet many with unclear significance. Students may find variants in their chosen genome related to ancestry, response to medications, the risk of developing diseases such as diabetes or cancer, and carrier status for single-gene disorders.
Mount Sinai also is conducting a questionnaire-based study to explore the degree to which course students who analyze their own genome demonstrate greater knowledge, as well as their perceptions regarding the utility of whole genome sequencing, and the impact on psychological wellbeing. This research will help faculty to learn how best to help students to interpret and analyze the wealth and complexity of genomic data, including potentially difficult findings such as risks of disease and carrier status. The results of the research study will be available after the course concludes in December.
The 20 students in the course represent a diverse collection of MD and PhD students, medical residents, genetic counseling students, and junior faculty. Though there was an emphasis on genetics, students were selected from a variety of backgrounds to reflect the interdisciplinary nature of applying genomic information to patient care, said Randi E. Zinberg, MS, CGC, Assistant Professor of Genetics and Genomic Sciences and of Obstetrics, Gynecology and Reproductive Science, and Director of the Graduate Program in Genetic Counseling at Mount Sinai School of Medicine.
We expect that courses such as ours will soon become an integral part of the curriculum at all medical schools. We look forward to sharing our learning from this course with other medical schools and graduate schools worldwide to help advance the breadth and depth of medical genetics education, Ms. Zinberg said.
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Mount Sinai School of Medicine Offers First-Ever Course with Whole Genome Sequencing
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The $1,000 Genome: A Bait and Switch?
Posted: at 7:19 pm
The concept of the $1,000 genome is "misleading," says Laura Hercher on the genetic counseling blog The DNA Exchange.
Hercher, a faculty member at Sarah Lawrence College, acknowledges that the cost of sequencing is dropping rapidly, but notes that the "$1,000 genome" doesn't mean that "getting your DNA sequenced will cost $1,000" because the number "covers only renewables those things like reagents and chips that are consumed in the process of sequencing. It does not include the cost of the sequencer or the cost of the tech who runs the sequencer. It does not cover overhead or profits. And most of all, it does not cover the costs associated with interpretation, without which a DNA sequence is merely an endless stream of A's, C's, T's and G's."
While much-hyped efforts like Mike Snyder's analysis of his own genome, which predicted that he had a high risk for diabetes, are commendable, "Snyder had available to him levels of expertise and medical care that are not in any way typical," Hercher says. "For much of America, paying for routine medical care is a challenge, and paying for acute or chronic medical care the most likely cause of personal bankruptcy."
Furthermore, she says, "Even people with money to spare don't usually get a sit-down with George Church to discuss their most disturbing sequence variants."
Hercher says that the $1,000 genome "is an enormous technical achievement" but warns that the scientific community should not "confuse people about what it means."
"The meme that represents the future of genetics should not be a bait-and-switch," she says.
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The $1,000 Genome: A Bait and Switch?
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Research and Markets: Key Findings from Treatment Algorithms: Psoriasis
Posted: at 7:18 pm
DUBLIN--(BUSINESS WIRE)--
Research and Markets (http://www.researchandmarkets.com/research/2rw494/key_findings_from) has announced the addition of Decision Resources, Inc's new report "Key Findings from Treatment Algorithms: Psoriasis" to their offering.
Psoriasis is a chronic inflammatory skin disease that, despite being non-life-threatening, has a tremendous impact on patients' quality of life. While topical therapies remain the mainstay of psoriasis treatment, the heightened awareness of psoriasis as a systemic disorder has led to an increased use of both conventional and biological systemic agents.
New entrants to the topicals arenaGalderma's vitamin D3 ointment Vectical (calcitriol) and Warner Chilcott's fixed-dose combination Taclonex (calcipotriene/betamethasone dipropionate)have increased the competition for patient share among topical agents owing to their more convenient administration (Taclonex) or steroid-sparing capacity (Vectical). In the moderate-to-severe psoriasis segment, the suboptimal side-effect profiles of the commonly used conventional systemics (i.e., methotrexate, cyclosporine) have opened the playing field to several biologics.
Among these, Amgen/Pfizer/Stiefel's TNF-a inhibitor Enbrel (etanercept) has historically captured the nearly all of biologics-eligible patients owing to dermatologists' comfort with its longstanding efficacy and safety record. However, Enbrel's positioning in the psoriasis treatment algorithm is becoming more vulnerable in light of increasing competition from newer entrants such as Abbott's Humira (adalimumab) and Janssen Biotech's interleukin-12 and -23 (IL-12/23) inhibitor Stelara (ustekinumab), both of which offer efficacy superior to that of Enbrel.
While Humira is establishing itself as a first-line biologic, Stelara's novel mechanism of action and limited long-term safety data have handicapped its uptake. Using patient-level claims data, this report determines the share of each currently marketed drug or class of drugs by line of therapy, evaluates therapy flow, and analyzes why key drugs are chosen over others.
Key Topics Covered:
1. Background
2. Key Findings for Newly Diagnosed Patients
3. Key Findings for Recently Treated Patients
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Research and Markets: Key Findings from Treatment Algorithms: Psoriasis
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Test Spots Newborn Gene Disease
Posted: at 7:18 pm
WASHINGTON (AP) - Too often, newborns die of genetic diseases before doctors even know what is to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.
The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.
Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Missouri, mapped the DNA of just five children, and the study wasn't done in time to help most of them.
But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit - and may offer testing for babies elsewhere, too - while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.
``For the first time, we can actually deliver genome information in time to make a difference," predicted Kingsmore, whose team reported the method in the journal Science Translational Medicine. Even if the diagnosis is a lethal disease, ``the family will at least have an answer. They won't have false hope," he added.
More than 20 percent of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases - from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.
Sequencing whole genomes - all of a person's DNA - can help when it is not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.
Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours, half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.
That's an estimate: The study counted only the time the blood was being decoded or analyzed, not the days needed to ship the blood to Essex, England, home of a speedy new DNA decoding machine made by Illumina, Inc., or to ship back the results for Children's Mercy's computer program to analyze. Kingsmore said the hospital is awaiting arrival of its own decoder, when 50 hours should become the true start-to-finish time.
Specialists not involved with the study said it signals the long-promised usefulness of gene-mapping to real-world medicine finally is close. ``Genomic sequencing like this is very practical and very real now," said Dr. Arthur Beaudet of the Baylor College of Medicine, which also is working to expand genomic testing in children. ``Fast forward a year, and I think this kind of thing will probably be pretty routine."
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Test Spots Newborn Gene Disease
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Mount Sinai researchers discover gene signature that predicts prostate cancer survival
Posted: at 7:18 pm
Public release date: 10-Oct-2012 [ | E-mail | Share ]
Contact: Mount Sinai Press Office newsmedia@mssm.edu 212-241-9200 The Mount Sinai Hospital / Mount Sinai School of Medicine
Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology. This is the first study to demonstrate how prognostic markers may be useful in a clinical setting.
Using blood from 202 men with treatment-resistant prostate cancer, researchers found six genes characteristic of treatment-resistant prostate cancer. Men with the six-gene signature were high-risk, with a survival time of 7.8 months, and men without it were low-risk, with a survival time of approximately 34.9 months. A replication study of 140 additional patients validated these findings. William K. Oh, MD, Chief of the Division of Hematology and Medical Oncology of The Tisch Cancer Institute at The Mount Sinai Medical Center, led the research team.
"There is an urgent need for predictive models that help assess how aggressive the disease is in prostate cancer patients, as survival can vary greatly," said Dr. Oh. "Our six-gene model, delivered in a simple blood test, will allow clinicians to better determine the course of action for their patients, determine clinical trial eligibility, and lead to more targeted studies in late-stage disease."
Until now, disease prognosis in advanced prostate cancer could only be determined through clinical predictors or, occasionally, tumor biopsies with only moderately predictive results. This study shows the efficacy of the six-gene model blood test in determining length of survival.
"The genes noted in the model suggest possible changes in the immune system related to late-stage disease that warrant further study as a target for immune-based therapies," said Dr. Oh.
Dr. Oh's team is conducting additional studies exploring the feasibility of the six-gene signature in other types of prostate cancer, the stability of the signature during the course of a patient's illness, and the predictive ability of this signature in patients with prostate cancer treated with immune-based therapies.
###
This work was done in collaboration with colleagues at Dana-Farber Cancer Institute in Boston and Memorial Sloan-Kettering Cancer Center in New York City.
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Mount Sinai researchers discover gene signature that predicts prostate cancer survival
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Democratic PAC using ‘loud’ Walsh in ads against colleagues Dold, Biggert
Posted: at 7:18 pm
By Natasha Korecki Sun-Times Media October 9, 2012 4:14PM
Three Democratic U.S. congressional candidates, Bill Foster, Brad Schneider and Tammy Duckworth. File photo. | John H. White~Chicago Sun-Times.
storyidforme: 38239530 tmspicid: 10042379 fileheaderid: 4623087
Updated: October 10, 2012 2:42AM
A pro-Democratic group is using video cuts of the loud, politically incorrect tea partyer Joe Walsh to turn up the volume against Republicans in three key Chicago-area races.
Walshs bluster is the centerpiece of a new spot, which is part of a $2.4 million ad buy attacking the 8th District congressman from McHenry, and two other Republicans who are targeted by Democrats.
Dont blame banks! I am tired of hearing that crap! Walsh is seen imploring on a video of him talking to district residents.
In another clip hes shown saying: I want America to pay for my contraceptives. Youre kidding me. Go get a job!
Clearly viewing Illinois as fertile ground to win over congressional seats, the House Majority PAC, which aims to put Democrats back into the lead in Washington, disclosed Tuesday it had pumped $2.4 million into the three key Chicago-area races including U.S. House races in the 8th, 10th and 11th congressional districts.
One video titled Loud links Walsh to U.S. Reps. Bob Dold of Kennilworth and Judy Biggert of Hinsdale, both of whom are incumbents. While Walsh is a tea partyer through and through, both Dold and Biggert are far more moderate. Still, the ad which, according to the House Majority PAC, will run in heavy rotation for two weeks works to link the three as equally out of step but only plays video snippets of Walsh talking.
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Democratic PAC using ‘loud’ Walsh in ads against colleagues Dold, Biggert
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