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Category Archives: Transhuman News

Stopping the itch: New clues into how to treat eczema

Posted: October 12, 2012 at 1:23 am

ScienceDaily (Oct. 11, 2012) More than 15% of children suffer with eczema, or atopic dermatitis, an inflammatory skin disease that in some cases can be debilitating and disfiguring. Researchers reporting in the October issue of Immunity have discovered a potential new target for the condition, demonstrating that by blocking it, they can lessen the disease in mice.

In eczema, immune T cells invade the skin and secrete factors that drive an allergic response, making the skin itch. Dr. Raif Geha, of Boston Children's Hospital, and his collaborators now show that scratching the skin precipitates the condition by encouraging an influx of other immune cells called neutrophils. These neutrophils secrete a lipid called leukotriene B4 that calls in more neutrophils, and more importantly, potent immune T cells that are the hallmark of eczema. These cells cause inflammation that aggravates the skin further. The investigators suspected that blocking the onslaught of these cells might slow down the disease or even stop it in its tracks.

Furthermore, Dr. Geha and his colleagues wondered whether the production of leukotriene B4 served to recruit T cells to the site of mechanical insult. And indeed that was the case. "We showed that a drug that blocks the production of leukotriene B4 blocks the development of allergic skin inflammation in a mouse model of eczema," says Dr. Geha. His team also found that deleting the receptors on immune cells that bind to leukotriene B4 had a similar effect.

"Our findings suggest that neutrophils play a key role in allergic skin inflammation and that blockade of leukotriene B4 and its receptor might provide a new therapy for eczema," says first author Dr. Michiko Oyoshi.

Most people get eczema as infants, and they tend to outgrow it by adolescence; however some people continue to experience "flare-ups" of an itchy rash on and off throughout life. Some develop these after coming into contact with particular substances, such as specific soaps, or in response to certain conditions, such as a respiratory infection or cold.

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The above story is reprinted from materials provided by Cell Press, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Internet censorship: Let it rot in walled gardens

Posted: at 1:22 am

October 11, 2012, 5:30 AM PDT

Takeaway: Attempts to shut us up in walled gardens and curb our online freedoms are impossible to implement and police. The nature of the internet sees to it that they are doomed to fail.

The quandary for governments is that because the web is ubiquitous and transparent it is hard to police and harder to censor. Photo: Shutterstock

John Gilmore, an internet activist who was also one of the co-founders of both the Electronic Frontier Foundation and the first free software company, Cygnus Solutions, once wrote that the net interprets censorship as damage and routes around it.

The internet was designed to enable military communications to find their way around points of failure in the event of a nuclear war. If one node fails or drops certain messages because it doesnt like their subject the messages find their way past that node anyway by some other route, according to Gilmore.

Censorship is practised for all kinds of political, social and commercial reasons, and all societies have limits on acceptable behaviour, but the point of the web is that there are no walled gardens and no limits to what we can access. If information wants to get out there, it will.

The idea that the internet is a universal resource that should be accessible to all is enshrined in the Declaration of Principles of the UN-sponsored World Summit on the Information Society (WSIS) of December 2003, which says, Everyone has the right to freedom of opinion and expression; that this right includes freedom to hold opinions without interference and to seek, receive and impart information and ideas through any media and regardless of frontiers.

Such declarations were relatively meaningless before the emergence of the world wide web, which has transformed the possibilities for information exchange and the dissemination of ideas, and how we respond to them.

Beyond the possibilities of static media, the internet can be seen as a democratising force. It has allowed us to interact with our peers across the cultural, racial, political and religious boundaries of the physical world, precisely because there are few barriers to what we say and how we say it, other than the approval or approbation of our peers.

What makes the internet different is that, unlike newspapers or television, it is interactive. We can determine what we read and how we read it. We are the editors and the filters. We can speak and share our vision with our fellow citizens on the opposite side of the globe without the interference of spokesmen or intermediaries.

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Paul's Texas district becomes Election Day fight

Posted: at 1:22 am

In Ron Paul's congressional district of 15 years, Democrats such as art gallery owner Elisabeth Lanier feel this could finally be their year to take the seat _ and not because of the political climate or how district lines were redrawn.

It's because "Dr. No" is no longer on the ballot.

"I'm sure he's a nice man and so forth," said Lanier, whose Galveston storefront was swamped with seven feet of water during Hurricane Ike in 2008, when Paul absorbed criticism for not doing more for his storm-battered constituents. "But he did virtually nothing and feels that government should do nothing."

Vying to succeed Paul are Republican state Rep. Randy Weber, who has Paul's endorsement, and former Democratic Congressman Nick Lampson, who replaced disgraced House Majority Leader Tom DeLay in his last stint in the U.S. House. It's one of only two competitive congressional races in Texas, though Weber has an edge in the coastal district that leans Republican.

Paul seldom had to worry about losing. He won re-election with at least 60 percent of the vote in his last six tries, including twice when Democrats didn't even bother putting a candidate on the ballot. He announced his retirement from Congress last year before announcing what became his latest failed presidential bid.

So much of a juggernaut was Paul _ and his national legion of supporters who kept his campaign pocketbook flush _ that local Democrats groused about the national party never putting money behind a challenger. Patricia Gray, a former state Democratic lawmaker from Galveston, has recalled party brass telling her that Paul couldn't be beat.

In the 14th Congressional District, Paul was a fixture on the biking trails in his hometown of Lake Jackson, sent cookbooks to his constituents and would sometimes answer the phone in his office. But apart from endorsing Weber, he has kept a low profile this campaign.

With Paul out of the picture, Democrats think their chances have greatly improved. The Democratic National Campaign Committee has given Lampson $5,000, according to Federal Election Commission reports. Lampson also has outraised Weber, who owns an air conditioning and heating business and has loaned himself $226,500 in the race.

"It may be (Republican-leaning)," Lampson said of the district. "But in the case of the congressional race, with the two people that are in it, I honestly believe it will not perform in that way. I'm different."

The district is different than before, too.

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Ron Paul Won't Endorse Romney, Says More of Same

Posted: at 1:22 am

Texas Republican congressman Ron Paul pointedly refused to endorse his party's presidential contender, Mitt Romney, arguing that neither he nor President Barack Obama would make necessary cuts to public spending that would avert a fiscal catastrophe.

"No," the iconoclastic Libertarian bluntly told CNBC's "Futures Now," when asked about whether he was prepared to endorse Romney. He accused both the former Massachusetts governor and the president of being captive to similar interests.

"Both within the establishment where they need the Federal Reserve as lender of last resort to make sure that you take all the risk in the world," Paul said. He linked the Fed -- his favorite foil -- and the Washington political establishment together as part of a "one party system" that refuses to make necessary but difficult choices to cut spending.

(Read more: Ron Paul Vows to Continue Campaign Against Status Quo.)

"I've been in this business a long time and believe me there is essentially no difference from one administration to another no matter what the platforms," said Paul, a former hopeful for the GOP nomination. "The foreign policy stays the same, the monetary policy stays the same, there's no proposal for any real cuts and both parties support it."

He cast some doubt that the looming fiscal cliff would have the economic impact many market observers are warning about, adding that Congress and the White House would likely find a way to delay the inevitable cuts in spending and tax hikes.

"They're not going to allow all those terrible things to happen on January 1, but they're not going to solve the problem either," Paul said.

(Read more: US Nears Fiscal Disaster: 'Washington Doing Nothing'.)

The congressman also took aim at one of the main targets of his ire, Fed chairman Ben Bernanke. Paul has been a relentless critic of the Fed's monetary policy.

As the central bank launches a third round of indefinite quantitative easing, or QE3, Paul renewed his charge that cheap and indefinite monetary policies would eventually wreak havoc on the U.S. economy. He predicted gold (xau=) would continue to rise while the U.S. dollar (.dxy) would bear the brunt of ultra-loose monetary policy.

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Ron Paul's district becomes an Election Day fight

Posted: at 1:22 am

By PAUL J. WEBER Associated Press

LEAGUE CITY, Texas (AP) - 1 of the few competitive Election Day races in Texas is a seat that hasn't been up for grabs in more than a decade: Ron Paul's congressional district.

The former presidential candidate is retiring from Congress after more than 20 years. Most of that was spent representing in the 14th Congressional District, where Republican Randy Weber and Democrat Nick Lampson are vying to become Paul's successor.

Weber is a state lawmaker who burnished a reputation as 1 of the most conservative members in the Texas Legislature. Lampson is trying to return to Congress, and is running as a moderate in a redrawn district that is no longer as firmly Republican.

Paul seldom worried about losing. He was re-elected with at least 60% of the vote his last six tries.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Ron Paul Won't Endorse Romney, Cites More of Same

Posted: at 1:21 am

Texas Republican congressman Ron Paul pointedly refused to endorse his partys presidential contender, Mitt Romney, arguing that neither he nor President Barack Obama would make necessary cuts to public spending that would avert a fiscal catastrophe.

Photo by Adam Jeffery for CNBC.com

Ron Paul

Both within the establishment where they need the Federal Reserve as lender of last resort to make sure that you take all the risk in the world, Paul said. He linked the Fed his favorite foil and the Washington political establishment together as part of a one party system that refuses to make necessary but difficult choices to cut spending. (Read more: Ron Paul Vows to Continue Campaign Against Status Quo.)

Ive been in this business a long time and believe me there is essentially no difference from one administration to another no matter what the platforms, said Paul, a former hopeful for the GOP nomination. The foreign policy stays the same, the monetary policy stays the same, theres no proposal for any real cuts and both parties support it.

He cast some doubt that the looming fiscal cliff would have the economic impact many market observers are warning about, adding that Congress and the White House would likely find a way to delay the inevitable cuts in spending and tax hikes.

Theyre not going to allow all those terrible things to happen on January 1, but theyre not going to solve the problem either, Paul said. (Read more: US Nears Fiscal Disaster: Washington Doing Nothing.)

The congressman also took aim at one of the main targets of his ire, Fed chairman Ben Bernanke. Paul has been a relentless critic of the Feds monetary policy.

As the central bank launches a third round of indefinite quantitative easing, or QE3, Paul renewed his charge that cheap and indefinite monetary policies would eventually wreak havoc on the U.S. economy. He predicted gold

Eternities with QEs are going to happen, Paul said. Bernanke will destroy the dollar if we dont come to our senses, and really cut spending and live within our means.

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UN envoy calls on Ivory Coast to release probe

Posted: at 1:21 am

ABIDJAN, Ivory Coast (AP) A senior United Nations human rights envoy is calling on Ivory Coast to release the full version of a national probe into last year's post-election violence.

Doudou Diene, the U.N.'s independent expert on human rights in the West African nation, said in an interview with The Associated Press on Thursday that publication of the report completed earlier this year by the National Commission of Inquiry was "a condition of reconciliation."

Ivory Coast headed to the brink of civil war after former President Laurent Gbagbo refused to concede defeat in the November 2010 presidential runoff vote to now-President Alassane Ouattara. The resulting violence, which ended in May 2011, claimed at least 3,000 lives, according to the U.N.

Despite evidence that supporters of both men committed grave crimes during the six-month conflict, only Gbagbo supporters have been charged, sparking allegations of victor's justice.

Gbagbo was transferred late last year to the International Criminal Court in The Hague, where he awaits trial on charges of crimes against humanity, and in Ivory Coast, more than 100 Gbagbo loyalists have been detained, accused of post-election crimes.

Human rights groups including New York-based Human Rights Watch have accused Ouattara's administration of biased justice. In response to that criticism, government officials had said they were waiting on the report from the National Commission of Inquiry before launching further judicial proceedings.

The report was handed over to Ouattara in August, but a summary version that was made public contained little new information and no names of suspected perpetrators.

In the interview Thursday, Diene, who is wrapping up a 19-day mission focused on impunity for gross human rights violations, said the commission's work would be of little consequence if its complete findings weren't made public.

"For that report to have an impact, it has to be publicized. It has to be part of the national debate of reconciliation, of truth and reconciliation," he said. "The Ivorian population has to know what happened, and to know it from a commission established by the state."

Justice Ministry officials were not available for comment Thursday. But in an interview when the report was released, Human Rights Minister Gnenema Coulibaly expressed reservations about making the full version of the report public, citing concerns about witness protection.

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Quincy Herald-Whig | Illinois & Missouri News, SportsGuinea creates 1st human rights ministerial post

Posted: at 1:21 am

CONAKRY, Guinea (AP) - Human rights groups applaud the creation of a new Cabinet post dedicated to human rights in Guinea, which has 1 of the worst records in West Africa, following a shocking 2009 massacre.

In that incident peaceful protesters were mowed down by the military inside the national soccer stadium, and dozens of women were gang raped.

Thierno Sow, head of Guinea's largest human rights group, said that it's the first time that human rights occupy such an important place in the Guinea government.

The post was created last week in the wake of a Cabinet reshuffle, which saw the purging of the last three members of the military serving in the government. It finalizes the transition to civilian rule which began after the massacre, when the military agreed to cede power.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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SpaceX Arrives at Space Station

Posted: October 11, 2012 at 11:18 am

A private company successfully delivered a half-ton of supplies to the International Space Station early Wednesday, the first official shipment under a billion-dollar contract with NASA.

The SpaceX cargo ship, called Dragon, eased up to the orbiting lab, and station astronauts reached out with a robot arm and snared it. Then they firmly latched it down.

"Looks like we've tamed the Dragon," reported space station commander Sunita Williams. "We're happy she's on board with us."

Williams thanked SpaceX and NASA for the delivery, especially the chocolate-vanilla swirl ice cream stashed in a freezer.

The linkup occurred 250 miles above the Pacific, just west of Baja California, 2 days after the Dragon's launch from Cape Canaveral, Fla.

"Nice flying," radioed NASA's Mission Control.

It's the first delivery by the California-based SpaceX company under a $1.6 billion contract with NASA. The contract calls for 12 such shipments.

This newest Dragon holds 1,000 pounds of groceries, clothes, science experiments and other gear. Williams and her crew won't get access to all that until Thursday, when the hatch is opened.

The vessel will remain at the space station for nearly three weeks before departing with almost twice that much cargo at the end of the month. Dragon is the only cargo ship capable of bringing back research and other items, filling a void left by NASA's retired shuttles.

AP

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Space Station Crew 'Tames' SpaceX Dragon

Posted: at 11:18 am

Astronauts aboard the International Space Station snared themselves a Dragon cargo capsule early Wednesday.

The freighter, launched Sunday evening by manufacturer Space Exploration Technologies, or SpaceX, flew itself to within 10 meters (about 33 feet) from the station, then shut down its rocket thrusters to let the station crew take over.

PHOTOS: Berthing a Dragon: An Astronaut's Spectacular View

Working from a control station inside the station's Cupola module, a small room with windows on seven sides, Japanese astronaut Akihiko Hoshide gently steered the station's 58-foot long robotic crane over to the Dragon cargo capsule and latched on to a grapple fixture at 6:56 a.m. EDT. The two spacecraft were flying in tandem at 17,500 mph about 250 miles over the Pacific Ocean, off the coast of Baja California in northwest Mexico, at the time.

"Looks like we tamed the Dragon," station commander Sunita Williams radioed to Mission Control in Houston.

"We're happy she's on board with us. Thanks to everybody at SpaceX and NASA for bringing her here to us. And the ice cream, she said.

ANALYSIS: SpaceX Falcon Rocket Flies

Dragon launched with a freezer to ferry medical research samples to and from the outpost. It was launched with ice cream inside, a rare treat for an orbiting crew.

Once the capsule is attached to the station, astronauts will begin unpacking the food, clothes, science experiments and science gear inside and filling it up with about a ton of cargo and experiments that needs to be returned to Earth.

Dragon is due to remain berthed at the station for 18 days, then parachute down into the Pacific Ocean for recovery. It will be the first large load of items to come back from the station since the space shuttles were retired last year.

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