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Category Archives: Transhuman News
The contribution of coding variants to psoriasis much smaller than thought
Posted: November 10, 2013 at 8:41 pm
PUBLIC RELEASE DATE:
10-Nov-2013
Contact: Jia Liu liujia@genomics.cn BGI Shenzhen
November 10, 2013, Shenzhen, China - Coding variants in immune disease-related genes play only a small part in the overall genetic risk for psoriasis, according to a new study led by Anhui Medical University and BGI. This conclusion is strongly supported by their investigation on the contribution of functional coding variants to psoriasis in 21,309 Chinese individuals. In such a large-scale investigation, researchers only discovered two independent low-frequency variants with moderate effect on disease risk. The latest study was published online in Nature Genetics.
Psoriasis is a complex, chronic, lifelong skin disease. It typically first strikes people between the ages of 15 to 35, but can affect anyone at any age, including children. This terrible disease is the results of the interaction of multiple factors, such as environment, genetics, and immunology. The rapid and cost-effective sequencing technologies have enabled researchers to dig out numerous risk-associated variants in psoriasis, but the functional coding variants, particularly low-frequency and rare variants, have not been systematically investigated.
In this study, researchers took two-phase to identify coding variants. In the discovery stage, they conducted exome sequencing on 781 patients with psoriasis and 676 people without psoriasis as control. The efforts yielded 518,308 single-nucleotide variants (SNVs). Of these variants, 20.62% were nonsynonymous, and 68.13% were rare.
Considering the limitation of sample size and techniques in the discovery stage, researchers performed 2 independent studies in a large sample of 9,946 patients with psoriasis and 9,906 controls using targeted sequencing. A total of 3.2 Mb of coding DNA surrounding the targeted regions of 1,326 genes (covering 133 SNVs, 622 immune diseaserelated genes, and some top genes) was captured. They totally identified 82,387 nonsynonymous SNVs, of which 97.07% were rare.
Through further analysis, they discovered two independent missense SNVs in IL23R and GJB2 with low frequency and five common missense SNVs in LCE3D, ERAP1, CARD14 and ZNF816A associated with psoriasis at genome-wide significance. The rare missense SNVs in FUT2 and TARBP1 were also observed with suggestive evidence of association with this disease.
In addition to the SNVs analysis, researchers investigated 622 immune disease-related genes, and the results showed that the coding variants, at least common and low-frequency nonsynonymous variants, have limited independent contribution to psoriasis risk. Taking all the findings together, the study indicated that nonsynonymous SNVs in the 1,326 targeted genes had limited contribution to the overall genetic risk of psoriasis.
Compared with previous work on European population, this research also demonstrated the genetic heterogeneity between European and Chinese populations. The missense variant (rs72474224) in GJB2 seemed to be specific to Chinese individuals, while the one (rs11209026) in IL23R was specific to European individuals. And another common missense variant (rs11652075) in CARD14 showed consistent between European and Chinese samples.
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The contribution of coding variants to psoriasis much smaller than thought
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Natural Psoriasis Treatments – 5 Remedies To Try Today! – Video
Posted: at 8:41 pm
Natural Psoriasis Treatments - 5 Remedies To Try Today!
http://naturaltreatmentsforpsoriasis.aedvz.com ? THE ONLY NATURAL TREATMENT FOR PSORIASIS THAT REALLY WORKS!!! psoriasis treatment treatment for psoriasis psoriasis skin scalp psoriasis...
By: TreatmentForPsoriasis
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Natural Psoriasis Treatments - 5 Remedies To Try Today! - Video
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St Martin, Politically Incorrect und die fairen Medien. – Video
Posted: at 8:41 pm
St Martin, Politically Incorrect und die fairen Medien.
St Martin, Politically Incorrect und die fairen Medien. http://www.pi-news.net/2013/11/bad-homburgs-sozialdezernent-st-martin-in-kita-wegen-sonne-mond-sterne...
By: Gustav Stresemann
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St Martin, Politically Incorrect und die fairen Medien. - Video
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Politically Incorrect: Are Transexuals Mentally Ill? – Video
Posted: at 8:41 pm
Politically Incorrect: Are Transexuals Mentally Ill?
Why do people think transexuals are actually the sex the claim to be? Please do not get offended. These are simply questions I have as opposed to attacks on transexuals. As far as I am aware...
By: Michael Anderson
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Politically Incorrect: Are Transexuals Mentally Ill? - Video
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GoogleTube CENSORSHIP Conspiracy (is REAL) – Video
Posted: at 8:41 pm
GoogleTube CENSORSHIP Conspiracy (is REAL)
It has begun..... UPDATE!! No kidding....AS SOON AS I POSTED THIS VIDEO....My comments and thumbs showed back up on my videos.....Weird timing to say the least.
By: TheScariestMovieEver
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GoogleTube CENSORSHIP Conspiracy (is REAL) - Video
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Blackbar review: An iPhone game about censorship that… No wait, come back! It's really good!
Posted: at 8:41 pm
Blackbar is a simple, elegant and witty word game for the iPhone. It's also a dystopian sci-fi adventure storyabout the cruelty of censorship. Yeah, now you're interested! Read on for our Blackbar review.
The best puzzle games for iPad & iPhone
A politically literate tirade against censorship; an Orwellian adventure story told through one half of an increasingly mangled email exchange; a puzzle game based entirely around decoding blocks of text. None of these things might sound like your idea of a merry time, but Blackbar is odd like that.
Playing the part of a downtrodden citizen of a dimly sketched dystopia, you receive a series of messages with parts blacked out by censors, and have to work out what the missing words are. It's easy at first, as these things generally are; but the game takes the idea and runs with it, tangling and weaving its internal logic until your head hurts.
You start off with this...
...and start filling in the blanks like this
It can be a frustrating game, in truth: we found ourselves head-scratching over a single word needed to unlock the next screen for days at a time. And the actual substance of the puzzles, when you remove this non-playing thinking time, is relatively thin. But Blackbar makes up for this by having a rather wonderful story - a story that's barely there, whispered to you in code and reassembled piece by piece.
Blackbar is often funny, particularly when the censors grow suspicious and start sending out entertainingly euphemistic threats; it's also a little bit politically charged. Every now and then it will catch you off guard and be rather moving. The writers, likethe US author Mark Z. Danielewski, are aware that piecing together the story yourself makes it that much more affecting.
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Blackbar review: An iPhone game about censorship that... No wait, come back! It's really good!
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Ron Paul Adds to Rand’s Horrible Week – Video
Posted: at 8:40 pm
Ron Paul Adds to Rand #39;s Horrible Week
Is Libertarian hero Ron Paul going back to his old newsletter days in his calls for nullification and revolution? Also, poor poor Rand... This clip from the ...
By: Sam Seder
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Ron Paul Adds to Rand's Horrible Week - Video
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Ron Paul speaks at Ken Cuccinelli Rally 11/04/13 – Video
Posted: at 8:40 pm
Ron Paul speaks at Ken Cuccinelli Rally 11/04/13
Ron Paul speaks at a Cuccinelli for Governor event in Richmond, Virginia on Nov. 4, 2013. Discusses the problems with big government, Obamacare, and taxes. P...
By: Bulwarker
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Ron Paul speaks at Ken Cuccinelli Rally 11/04/13 - Video
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Ron Paul: Obamacare ‘A Conspiracy Of Stupidity’ – Video
Posted: at 8:40 pm
Ron Paul: Obamacare #39;A Conspiracy Of Stupidity #39;
Air Date: Nov. 4th, 2013 This video may contain copyrighted material. Such material is made available for educational purposes only. This constitutes a #39;fair...
By: selfownership1
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Ron Paul: Obamacare 'A Conspiracy Of Stupidity' - Video
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Ron Paul: The Economic Crisis On Our Doorstep – Video
Posted: at 8:40 pm
Ron Paul: The Economic Crisis On Our Doorstep
Dr. Ron Paul was formerly the U.S. Representative for Texas #39;s 14th congressional district. He has also been a three-time candidate for President of the Unite...
By: Libertarianism.org
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Ron Paul: The Economic Crisis On Our Doorstep - Video
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