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Category Archives: Transhuman News
Stanford researchers compare mammals' genomes to aid human clinical research
Posted: November 19, 2014 at 6:45 pm
PUBLIC RELEASE DATE:
19-Nov-2014
Contact: Krista Conger kristac@stanford.edu 650-725-5371 Stanford University Medical Center @sumedicine
For years, scientists have considered the laboratory mouse one of the best models for researching disease in humans because of the genetic similarity between the two mammals. Now, researchers at the Stanford University School of Medicine have found that the basic principles of how genes are controlled are similar in the two species, validating the mouse's utility in clinical research.
However, there are important differences in the details of gene regulation that distinguish us as a species.
"At the end of the day, a lot of the genes are identical between a mouse and a human, but we would argue how they're regulated is quite different," said Michael Snyder, PhD, professor and chair of genetics at Stanford. "We are interested in what makes a mouse a mouse and a human a human."
The research effort, Mouse ENCODE, is meant to complement a project called the Encyclopedia of DNA Elements, or ENCODE, that began in 2003. ENCODE studied specific components in the human genome that guide genes to code for proteins that carry out a cell's function, a process known as gene expression. Surrounding the protein-coding genes are noncoding regulatory elements, molecules that regulate gene expression by attaching proteins, called transcription factors, to specific regions of DNA.
Why mice matter
Mouse ENCODE analyzed more than 100 mouse cell types and tissues to annotate the regulatory elements of the mouse genome and compare them to the regulatory elements in the human genome. Both ENCODE and Mouse ENCODE are funded and coordinated by the National Human Genome Research Institute. Because mice are used as model organisms for many human clinical studies and drug discovery, understanding the similarities and differences can help researchers understand how the results found in mouse studies can translate to humans.
"The mindset is when you compare things, it helps understand genome annotation," said Mark Gerstein, PhD, the Albert L. Williams Professor of Biomedical Informatics at Yale University. "It's making the mouse a more meaningful model organism." Gerstein collaborated on previous ENCODE research but is not part of the Mouse ENCODE consortium, which is composed of researchers from more than 30 institutions.
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Stanford researchers compare mammals' genomes to aid human clinical research
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CoD Advanced Warfare: SOLO "DNA BOMB" on Horizone *MEINE ERSTE DNA :D* – Video
Posted: at 6:44 pm
CoD Advanced Warfare: SOLO "DNA BOMB" on Horizone *MEINE ERSTE DNA :D*
MEIN LETZTES VIDEO https://www.youtube.com/watch?v=lFvd6f9QKS0 list=UUWppOwTB8gdWL-SgNdrZEVA ...
By: MalliB115
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CoD Advanced Warfare: SOLO "DNA BOMB" on Horizone *MEINE ERSTE DNA :D* - Video
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Advanced Warfare: 52 KILLSTREAK DNA BOMB! (DNA Bomb Gameplay Advanced Warfare) – Video
Posted: at 6:44 pm
Advanced Warfare: 52 KILLSTREAK DNA BOMB! (DNA Bomb Gameplay Advanced Warfare)
DNA Bomb Gameplay - Can we get 2000 Likes? My First DNA Bomb - http://youtu.be/AgD9c5JoPiM Enjoy this Fast 52 Killstreak DNA Bomb Gameplay On Horizon and be sure to subscribe and check ...
By: GreenGoblinHD
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Advanced Warfare: 52 KILLSTREAK DNA BOMB! (DNA Bomb Gameplay Advanced Warfare) - Video
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COD Advanced Warfare SNIPER DNA BOMB! (2:47 World’s Fastest) – MORS QUICKSCOPING + 44 Gunstreak! – Video
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COD Advanced Warfare SNIPER DNA BOMB! (2:47 World #39;s Fastest) - MORS QUICKSCOPING + 44 Gunstreak!
COD Advanced Warfare SNIPER DNA BOMB! (2:47 World #39;s Fastest) - MORS QUICKSCOPING + 44 Gunstreak! Player: http://www.youtube.com/user/BlackSharp1 Commentator: ...
By: Overpowered Clan
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COD Advanced Warfare SNIPER DNA BOMB! (2:47 World's Fastest) - MORS QUICKSCOPING + 44 Gunstreak! - Video
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DNA leads to arrest of man accused of raping 101-year-old woman – Video
Posted: at 6:44 pm
DNA leads to arrest of man accused of raping 101-year-old woman
MILWAUKEE For the second time in state history, the DNA of a relative has led to the arrest of a suspect wanted for sexual assault.
By: todaystmj4
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DNA leads to arrest of man accused of raping 101-year-old woman - Video
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DNA DANCE CLUB SKALA LAKONIAS 15-11-2014 – Video
Posted: at 6:44 pm
DNA DANCE CLUB SKALA LAKONIAS 15-11-2014
By: alina rusu
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Dna solo aaa ragazzi – Video
Posted: at 6:44 pm
Dna solo aaa ragazzi
Come si faa come si fa a ascoltare questo.
By: dnasoloseriea!!!!!!! Enna francesco
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Dna solo aaa ragazzi - Video
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Advanced Warfare – ASM1 SMG "DNA BOMB" ON HORIZON! (COD AW 30 Gunstreak) – Video
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Advanced Warfare - ASM1 SMG "DNA BOMB" ON HORIZON! (COD AW 30 Gunstreak)
Advanced Warfare - ASM1 SMG "DNA BOMB" ON HORIZON! (COD AW 30 Gunstreak) DNA Bomb by: http://www.youtube.com/GAMEPLAAAYS Commentator: ...
By: KARNAGE Clan
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Advanced Warfare - ASM1 SMG "DNA BOMB" ON HORIZON! (COD AW 30 Gunstreak) - Video
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DNA 40 in VAPORSHARK RDNA (GERMAN) – VIENNA VAPER REVIEWS – Video
Posted: at 6:44 pm
DNA 40 in VAPORSHARK RDNA (GERMAN) - VIENNA VAPER REVIEWS
Hier mal eine echte Neuheit! Der DNA 40 - viel Spass...
By: Vienna Vaper
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DNA 40 in VAPORSHARK RDNA (GERMAN) - VIENNA VAPER REVIEWS - Video
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DNA methylation: The role it plays in aging cells
Posted: at 6:44 pm
Although every person's DNA remains the same throughout their lives, scientists know that it functions differently at different ages.
As people age, drastic changes occur in their DNA methylation patterns, which are thought to act as a "second code" on top of the DNA that can lock genes in the on or off position. However, what the consequences of these changes are remains a mystery.
To begin deciphering this process, scientists at Wake Forest Baptist Medical Center studied methylation patterns in the blood cells of 1,264 persons ages 55 to 94 who participated in the Multi-Ethnic Study of Atherosclerosis (MESA).
In a study published in the current issue of Nature Communications, the researchers found age-related differences in DNA methylation in 8 percent of the 450,000 sites tested across the genome. Most of these changes did not seem to affect which cellular genes were turned on or off.
However, the Wake Forest Baptist team did find a small subset of age-linked DNA methylation changes -- 1,794 of the 450,000 sites tested -- that were associated with altered gene expression. Out of this subset, 42 sites were associated with pulse pressure, a measure of vascular health that is known to change with age.
"Our work suggests that most of the age-associated changes in DNA methylation do not have an obvious effect on cellular function, in this case altering gene expression, and some of them may just amount to noise," said Yongmei Liu, M.D., Ph.D., associate professor of public health sciences at Wake Forest Baptist and corresponding author of the study.
"The methylation sites that are linked to altered gene expression are good candidates as potential drivers of the negative effects of aging, especially the small subset linked to pulse pressure. Our findings provide new insights into the aging process."
Future studies will try to test the relationship between these methylation sites and specific health outcomes, Liu said. Eventually, the scientists hope to be able to target and reverse specific sites that are involved with age-related diseases.
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The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length.
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