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Category Archives: Transhuman News

We Think Cavco Industries (NASDAQ:CVCO) Might Have The DNA Of A Multi-Bagger – Yahoo Finance

Posted: January 23, 2024 at 5:44 pm

We Think Cavco Industries (NASDAQ:CVCO) Might Have The DNA Of A Multi-Bagger  Yahoo Finance

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DNA From the Ocean’s ‘Twilight Zone’ Could Lead to New Lifesaving Drugs, Scientists Say – Smithsonian Magazine

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Scientists produced the most complete catalog of marine microbe DNA yet, including data from the deeper zones of the oceans. Rowan Coe via Getty Images

As of Tuesday, scientists around the world have an exciting new tool at their disposal: the largest-ever collection of marine microbe genomes, organized in an online database.

The catalog, described in the journal Frontiers in Science, is an open-source digital library of genetic codes from the oceans organismsand scientists say it may open doors to drug development or innovations in energy and agriculture.

Genes and proteins derived from marine microbes have endless potential applications, study co-author Carlos Duarte, a marine ecologist at the King Abdullah University of Science and Technology (KAUST) in Saudi Arabia, says to Nature News Carissa Wong. We can probe for new antibiotics; we can find new enzymes for food production. If they know what theyre searching for, researchers can use our platform to find the needle in the haystack that can address a specific problem.

To build the database, researchers analyzed thousands of marine samples collected over the last 15 years, from all five oceans and the Mediterranean Sea. The samples were sourced from a variety of past expeditions and studies, such as the global Tara Oceans expedition that ran from 2009 to 2013. The DNA represented bacteria, fungi and viruses from a variety of geographies and oceanic depths.

In the past, barriers to DNA sequencing presented a major roadblock for scientistseven when the genetic samples were collected and in hand, their efforts could be foiled by cost, time or the condition of the DNA. As of 2022, 303 million unique marine microbial genes had been sequenced.

The teams breakthrough came via sequencing and technological advances. Improvements in the speed and accuracy of supercomputing, as well as developments in artificial intelligence and shotgun DNA sequencing, allowed the team to analyze more than 2,100 metagenomes, or bulk quantities of genetic material. All told, they sequenced approximately 317 million unique groups of microbial genes to create the most complete catalog yet.

In particular, the study took a close look at life accustomed to the extreme conditions of the oceanic twilight zone. Stretching between 650 and 3,300 feet below the surfacejust out of range for sunlightthis region is home to some of Earths most unique creatures, with adaptations driven by such a harsh habitat.

Within the twilight zone, researchers were surprised to discover that more than half of the unique gene clusters found belonged to fungi.

There have been some indications of [fungi abundance at this level] before, so this is another piece of the puzzle, lead author Elisa Laiolo, a marine biologist at KAUST, says to the Guardians Sophie Kevany.

Drugs like penicillin, for example, were developed from fungi. And the ones found in the deep ocean have evolved rare traits that could be useful to scientists developing medicines. That could potentially lead to the discovery of new species with unique biochemical properties, Fabio Favoretto, a marine ecologist at the Scripps Institution of Oceanography who was not involved in the research, tells the Guardian.We might find something like [penicillin] from these ocean fungi.

Examining marine microbes also shed light on viruses role in increasing genetic diversity, which they do by moving genes between organisms.

The study suggests avenues for future researchfor example, the scientists identified a wide gap in knowledge about the deep sea and ocean floor. They also point out that their catalog can serve as a baseline for the diversity of marine microbes, which could allow future researchers to gauge the impact of human activitiessuch as deep-sea mining or burning fossil fuelson these organisms, per Nature News.

For the catalog to truly be effective, the team says, countries and scientists need to prioritize the dissemination of knowledge. The 2023 high seas treaty, which nearly 200 countries signed, maintains that a marine gene is owned by the country that discovers it, though its benefits must be shared. Still, the agreement was unclear on how that would work.

Such uncertainty must be resolved now we have reached the point where genetic and artificial intelligence technologies could unlock unprecedented innovation and progress in blue biotechnology, Duarte says in a statement.

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DNA From the Ocean's 'Twilight Zone' Could Lead to New Lifesaving Drugs, Scientists Say - Smithsonian Magazine

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Last known remains connected to the Green River Killer identified through DNA – KOMO News

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Last known remains connected to the Green River Killer identified through DNA  KOMO News

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9/11 victim identified as John Ballantine Niven of Oyster Bay with help of DNA technology – WABC-TV

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9/11 victim identified as John Ballantine Niven of Oyster Bay with help of DNA technology  WABC-TV

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Scott Peterson has every right to DNA test: Attorney from case – NewsNation Now

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Scott Peterson has every right to DNA test: Attorney from case  NewsNation Now

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DNA from stone age chewing gum sheds light on diet and disease in Scandinavia’s ancient hunter-gatherers – The Conversation

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Some 9,700 years ago on an autumn day, a group of people were camping on the west coast of Scandinavia. They were hunter-gatherers that had been fishing, hunting and collecting resources in the area.

Some teenagers, both boys and girls, were chewing resin to produce glue, just after eating trout, deer and hazelnuts. Due to a severe gum infection (periodontitis), one of the teenagers had problems eating the chewy deer-meat, as well as preparing the resin by chewing it.

This snapshot of the Mesolithic period, just before Europeans started farming, comes from analysis of DNA left in the chewed resin that we have conducted, now published in Scientific Reports.

The location is now known as Huseby Klev, situated north of Gothenburg (Gteborg), Sweden. It was excavated by archaeologists in the early 1990s, and yielded some 1,849 flint artefacts and 115 pieces of resin (mastic). The site has been radiocarbon dated to between 10,200 and 9,400 years ago, with one of the pieces of resin dated to 9,700 years ago.

Some of the resin has teeth imprints, indicating that children, actually teenagers, had been chewing them. Masticated lumps, often with imprints of teeth, fingerprints or both, are not uncommon to find in Mesolithic sites.

The pieces of resin we have analysed were made of birch bark pitch, which is known to have been used as an adhesive substance in stone tool technology from the Middle Palaeolithic onward. However, they were also chewed for recreational or medicinal purposes in traditional societies.

A variety of substances with similar properties, such as resins from coniferous trees, natural bitumen, and other plant gums, are known to have been used in analogous ways in many parts of the world.

In some of the resin, half the DNA extracted was of human origin. This is a lot compared to what we often find in ancient bones and teeth.

It represents some of the oldest human genomes from Scandinavia. It has a particular ancestry profile common among Mesolithic hunter gatherers who once lived there.

Some of the resin contains male human DNA while others have female DNA. We think that teenagers of both sexes were preparing glue for use in tool making, such as attaching a stone axe to a wooden handle.

But what of the other half of the DNA that was of non-human origin? Most of this DNA is from organisms such as bacteria and fungi that have lived in the mastic since it was discarded 9,700 years ago. But some of it was from bacteria living in the human that chewed it, along with material the human had been chewing on before they put the birch bark pitch in their mouths.

Analysing all this DNA is a demanding task and treads new ground. We had to both adapt existing computing tools and also develop some new analytical strategies. As such, this work has become the starting point for developing a new workflow for this kind of analysis.

This includes mining the DNA using different strategies to characterise it, trying to piece together short DNA fragments into longer ones and using machine learning techniques to work out which DNA fragments belong to pathogens (harmful microorganisms). It also involves comparing the data to what we see in the mouths of modern people with tooth decay (caries) and periodontitis.

Naturally, we found the kind of bacteria that would be expected in an oral microbiome, the range of naturally occurring microorganisms found in the mouth. We also found traces of bacteria implicated in conditions such as tooth decay or caries (Streptococcus mutans), and systemic diseases such as Hib disease and endocarditis. There were also bacteria that can cause abscesses.

Although these pathogenic microorganisms were present at an elevated frequency, they were not clearly above the level expected for a healthy oral microbiome. There is thus no conclusive evidence that members of the group suffered from diseases these microorganisms are associated with.

What we did find, however, was an abundance of bacteria associated with serious gum disease periodontitis. When we applied a machine learning strategy (in this case, a technique called Random Forest modelling) we reached the conclusion that the girl who chewed one of the pieces of resin had probably suffered from periodontitis with more than a 75% probability.

We also found DNA from larger organisms than just bacteria. We found DNA for red deer, brown trout and hazelnuts. This DNA probably came from material the teenagers had been chewing before they put the birch pitch in their mouths.

However, we need to be a little bit cautious because exactly what we find is also dependent on the comparison data that we have. As genomes from eukaryotic organisms the group that includes plants and animals are larger and more complex than those from microorganisms, it is more complicated to assemble a eukaryotic genome of high quality.

There are fewer eukaryotic genomes in the samples of resin, and they are of lower quality. This means that our brown trout, for example, may not actually be a brown trout, but we at least feel certain it is from the salmon family.

We also found a lot of fox DNA, but this is harder to interpret. Fox meat may have been a part of the diet, but these teenagers could also have chewed on tendons and fur from foxes for use in textiles. Alternatively, the fox DNA could even be from territorial marking and got into the resin after it was spat out.

However, what we have learned for sure represents a big step in understanding these fascinating records of human culture from the Stone Age. As we analyse more of these, even more surprises could emerge.

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DNA from stone age chewing gum sheds light on diet and disease in Scandinavia's ancient hunter-gatherers - The Conversation

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Barbara Lee responds to Nikki Haley: Racism is in the DNA of this country – The Hill

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Barbara Lee responds to Nikki Haley: Racism is in the DNA of this country  The Hill

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DB Cooper ‘will finally be identified’ after 53 years due to huge DNA breakthrough – LADbible

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An expert has said the identity of DB Cooper could be revealed for the first time thanks to a DNA breakthrough.

On 24 November 1971, Northwest Airlines Flight 305 was hijacked by a mystery man who claimed to be carrying a bomb - he demanded $200,000 in ransom before donning a parachute and jumping from the plane.

The only clue he left behind was a clip-on tie from the US retail chain JCPenney.

Speaking to the Sun, he said that he had recently met with scientist Tom Kaye who has tested the tie twice using a special device that is able to collect the smallest particles.

Kaye was initially hoping to analyse the tie for traces of certain chemicals or metals which could help shed some light on its owner - but the duo claim the device is also able to collect DNA.

The pair now plan on sharing the DNA they captured with a lab that specialises in metagenomic DNA analysis - an incredibly advanced type of DNA analysis that enables scientists to separate individual strands of DNA.

He told the publication: "Metagenomic DNA is the holy grail where this is concerned because it can separate individually all of the DNA profiles on the tie, even for something like a dog.

"So if DB Cooper had a dog, we'd be able to find that on there.

"It's critically important because [...] let's say you have a dozen different DNA profiles on that tie from everyone who has come into contact with it over the years, including various FBI agents and Cooper himself.

"We will be able to separate all of those strands individually, and - while we won't know which one is Cooper's - we will be able to gradually narrow them down."

If all goes well, Ulis is hopeful that this case could be closed by the end of the year.

"By December 31, 2024, this is going to be a new world as far as this case is concerned," he said.

"We're either going to have figured out who this guy is, or we're gonna have a solid DNA profile to work with that's going to be pointing us in the right direction."

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DB Cooper 'will finally be identified' after 53 years due to huge DNA breakthrough - LADbible

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Dog Owners Who Abandon Poops To Be Found Using DNA Tests in Italy – Newsweek

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Dog Owners Who Abandon Poops To Be Found Using DNA Tests in Italy  Newsweek

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Global censorship campaign raises alarms – Freedom of the Press Foundation

Posted: January 21, 2024 at 11:51 pm

News outlets worldwide have been heeding demands to remove articles about an Indian tech company called Appin and its co-founder, Rajat Khare. Major U.S. outlets are among those that have been successfully pressured to take down their reporting not just in India, but here as well.

The ordeal raises serious concerns about the global reach of local judges thousands of miles away. It also raises questions about the adequacy of existing legal safeguards to deal with international censorship campaigns arising from countries like India, with governments that dont respect human rights, let alone press freedom. Even when the government is not directly involved in a censorship campaign, its reputation precedes it, and it would be impossible for news publishers not to take note.

Multiple news outlets take down stories globally

Everyone from Reuters to the U.K.s The Sunday Times and outlets in Luxembourg and Switzerland has censored their reporting about Khare and Appin after either lawsuits or takedown letters, according to a report in the Daily Beast. The legal actions often come from an entity calling itself the Association of Appin Training Centers or its alleged executives.

Reuters, for example, ran a detailed investigation last November about how Appin functioned as a hack-for-hire powerhouse. Khare and Appin vehemently deny the allegations. Reuters published the article despite an injunction, entered in 2022, prohibiting it from reporting anything defamatory about the association. Presumably, Reuters believed the article wasnt defamatory, so the injunction wouldnt apply.

But within weeks, an Indian court deemed the article indicative of defamation despite failing to identify any fallacies in the report and ordered it removed from the internet. Reuters complied, taking down the article not just in India but around the world. Even the Internet Archives Wayback Machine removed the Reuters story. Fortunately, DDoSecrets has stepped up to host the Reuters story and other censored reporting. (Sidenote: It is raising funds so it can continue doing its important work.)

The order doesnt expressly limit the required takedown to India, which may suggest the Indian court intended it to be removed globally. But Indian courts dont have global jurisdiction. And a U.S. court would be particularly unlikely to enforce the order, given the nearly insurmountable constitutional presumption against prohibitions on publication, or prior restraints. Theres even a law in the U.S., the SPEECH Act, against honoring defamation judgments from countries that dont protect free speech.

So why did Reuters remove the story in the U.S. and everywhere else, replacing it with an editors note that it stands by its reporting and plans to appeal (a slow process anywhere, but especially in India)? And why have so many others complied with takedown demands?

Some publications, like The New Yorker, have kept their stories up despite reported threats from Khares lawyers (which reportedly included the firm Clare Locke, known for representing Dominion Voting Systems in its defamation suit against Fox News), but at least 18 other outlets also either removed articles about Appin outright or erased mentions of Khare.

It cant just be ignorance of the law. Khare is far from the first rich guy to try to silence critics. Reuters and other censored outlets have plenty of First Amendment lawyers and must know U.S. law is on their side. They also know that Clare Locke succeeded in the Dominion case largely because it had some very helpful evidence to work with, not because it possesses some secret legal magic wand that makes the First Amendment disappear.

Demands for removal leverage risk of deplatforming by tech companies

A closer look at the associations tactics may provide answers. For one, the order in the Reuters case not only requires the story to be taken down by Reuters but to be deindexed by Google. The association is making sure to let its other targets know about that, including in a recent takedown letter to Ron Deibert of the Citizen Lab (judging from Deiberts X post about the letter, hes unlikely to take down his article). Others have received similar letters.

Perhaps the message is that resistance is futile: Theres no point in paying lawyers to fight takedown demands if, at the end of the day, Google can make the articles invisible anyway.

But another line from the letter to Deibert stood out even more: It claims the article is contemptuous not only to the Plaintiffs concerned however it is absolutely derogatory to the entire Indian Nation. The article says nothing about India in its entirety.

Further nationalistic language appears in correspondence to Meta, attached to court documents filed in the Reuters case. Those letters, from the association's Indian counsel, baselessly accuse the journalists behind the Reuters story (Christopher Bing, Zeba Siddiqui, and Raphael Satter) of a serious unusual espionage operation and a well-planned modus operandi to malign Ruling Indian Government, demanding Meta therefore block their WhatsApp accounts.

According to court documents, the association also sent demands to block the journalists accounts on LinkedIn and Naukri, an Indian platform they allegedly used to contact potential sources. Fortunately, neither LinkedIn nor Meta appears to have complied to date, but the threat of deindexing or deplatforming is a powerful cudgel. Tools like WhatsApp are essential for journalists these days.

Veiled threats have an impact regardless of credibility

The allusions to the nation of India and its current rulers in legal correspondence about disputes between private companies also may serve another purpose.

The administration of Prime Minister Narendra Modi is infamous for its crackdowns on speech and the press, especially online. India, for example, managed to tame Twitter with its hostage law, requiring social media companies to keep representatives in the country for authorities to arrest if their employers misbehave. That law may not bind news outlets, but it doesnt have to. They need to have personnel in India if they want to cover news there.

Lawyers in the suit against Reuters have already asked for the three reporters to be jailed. Theyre not based in India, but might authorities arrest someone else in their place? News outlets may not want to find out the hard way, especially if theyre under the impression that theyve offended the Ruling Indian Government.

Were unaware of any indication that the Modi administration takes criticism of Appin or Khare personally or would even care at all. The claim that the Reuters article maligns the current government is perplexing given that the reporting focuses on events predating Modis 2014 inauguration. As for Khare, hes now an Antiguan national living in Switzerland.

Nonetheless, perhaps the associations intent in invoking the Ruling Indian Government is to issue a not-so-subtle reminder, to anyone considering flouting its demands, of who they may be messing with. And it seems to be working. Bluff or not, news outlets may be afraid to call it.

American legal protections cant stop foreign censorship tactics

While the U.S. may not always be the global leader in press freedom it thinks it is, its legal protections against foreign censorship orders are relatively strong. But that may not matter if others follow Appins playbook.

U.S. outlets know the First Amendment cant protect them from stories being suppressed, or reporters deplatformed, by tech companies at the behest of foreign courts. It also provides no solace against veiled threats, however noncredible they may be, to sic authoritarian regimes on journalists.

The aforementioned SPEECH Act was intended largely to stop U.S. courts from enforcing judgments entered under the U.K.s plaintiff-friendly libel laws. Thats helpful when U.S. outlets are primarily worried about legal risk back home. But in cases arising from countries ruled by governments like Modis, there may be larger concerns than that.

And if the U.S. is going to continue its partnerships with such countries, then policymakers here need to think seriously about how to address those concerns.

The Biden administration has maintained that it wont lecture India about its domestic human rights problems (although recent reporting says alleged Indian assassination plots have complicated the U.S.-India relationship). But censorship emanating from Indian courts is not a domestic issue when its stopping U.S. citizens from reading important news about a U.S. strategic partner. Whether or not Indias government had any direct involvement with this latest campaign to silence the press, it may have created the climate that enabled it.

If the U.S. insists on partnering with censorial regimes, then policymakers need to start thinking seriously about the consequences for free speech back home, and the administration needs to do more to stand up for American values than empty talk. Otherwise who is going to tell us about the next hack-for-hire operation or assassination plot, for that matter?

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