Category Archives: Human Longevity

JERUSALEM, Jan. 12, 2022 (GLOBE NEWSWIRE) -- Recently, a start-up project "LifeBank Chain (LBC)" in Israel is utilizing advanced gene and cell technologies over blockchain to develop advanced therapies. They endeavor to further human longevity and expand access to genetics and cell treatments through cutting-edge technologies.

Gene therapy involves altering the genes inside human body's cells in an effort to treat or stop disease. Genes that don't work properly can cause disease. Gene therapy is the introduction of genes into existing cells to prevent or cure a wide range of diseases. Gene therapy is an exciting new approach that is just making the news. And it will change the field of medicine from what it is today. As scientists discover more genes and their functions, the potential of LBC's treatment is limitless.

Cell therapy is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy. LBC's cellular therapies are designed to improve the immune system's ability to fight cancer. Manufacturing them involves collecting a specific set of cells from the blood, modifying them to produce a more vigorous attack on a patient's cancer cells, and then reinjecting them into the patient.

Immune therapy is a new class of cancer treatment designed to boost or enhance the body's immune system to more efficiently target and destroy cancerous cells. Many experts believe that immunotherapy represents the most promising new cancer treatment since the development of chemotherapy.

LifeBank Chain (LBC) is on this journey. As a full-solution ancillary reagent, services, and instrument provider, LBC will provide flexible and pioneering tools to simplify patient workflow at every step of the manufacturing process.

Count on LBC to provide solutions focused on:

To achieve this ultimate goal, LifeBank Chain establishes a professional, open, and shared social organization -- LBC Life Alliance, inviting life technology companies, scientific research institutes, medical institutions, etc. to jointly solve medical, health, disease, and public health problems, and jointly build the application standards of gene and cell medical technology on the blockchain, and contribute to the cause of human health.

In order to promote the research of gene and cell therapy and the development of regenerative medicine, and ensure the safety and scientificity of gene and cell therapy and its research, LBC adopts comprehensive measures in relevant ethics, economy, law, technical management and public governance to create a better research environment for gene and cell therapy development.

LifeBank Chain:

https://lifebankchain.io

Twitter: https://twitter.com/lifebankchain

Email: lbc@lifebankchain.io

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Gene and Cell Therapy Benefits to Everyone

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LifeBank Chain Brings Ultimate Gene and Cell Therapy Benefits to Everyone - GlobeNewswire

The lifespan of Americans has increased considerably over the last century. Lifespan at birth in 1920 was 53 years. That figure jumped to 79 years in 2020. Some people live much longer than that. The oldest American on record lived to be 119. But human lifespans are a fraction of those of some animals.

To find the longest living animal in the world, 24/7 Tempo reviewed data in the Human Ageing Genomic Resources database collection specifically, the AnAge animal longevity database.

Cynthia Kenyon is a biochemist and geneticist working on unlocking the secrets of longevity. At a TED talk in Edinburgh, Scotland, eight years ago, she talked about aging. There are some animals that dont seem to age, said Kenyon. If you look at birds, which live a long time, cells from the birds tend to be more resistant to a lot of environmental stresses like high temperature, or hydrogen peroxide.

About three-fourths of the species we considered are either fish or mammals like whales that live in the ocean. Size doesnt appear to be a factor in how long animals live. Salamanders called olms that weigh less than an ounce can live as long as 102 years. The largest animal on Earth, the blue whale, can live to be up to 110 years. Despite its size, the blue whale is not among the most dangerous mammals on Earth.

To identify the longest living animal in the world, 24/7 Tempo reviewed animal aging and longevity data from AnAge, a curated database on animal history, genomes, and longevity records, that is part of the Human Ageing Genomic Resources (HAGR) suite of databases. The longest-living animals were identified by examining their maximum longevity, supplemented by our analysis of specimen, kingdom, and genus. Only organisms from the Kingdom Animalia were included. Animals from the phylum Porifera, such as sponges, were excluded. Average adult weight of each organism that were not provided by AnAge were confirmed by a variety of internet sources. Only animals considered to have an acceptable data quality or higher by AnAge were included.

The oldest living animal in the world is the Ocean quahog clam. Here are the details:> Oldest recorded: 507 years> Average adult weight: 0.5 lbs.> Habitat: Northern Atlantic Ocean

Methodology: To identify the longest living animal in the world, 24/7 Tempo reviewed animal aging and longevity data from AnAge, a curated database on animal history, genomes, and longevity records, that is part of the Human Ageing Genomic Resources (HAGR) suite of databases. The longest-living animals were identified by examining their maximum longevity, supplemented by our analysis of specimen, kingdom, and genus. Only organisms from the Kingdom Animalia were included. Animals from the phylum Porifera, such as sponges, were excluded. Average adult weight of each organism that were not provided by AnAge were confirmed by a variety of internet sources. Only animals considered to have an acceptable data quality or higher by AnAge were included.

Click here to read The 50 Longest Living Animals In The World

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The Longest-Living Animal in the World - 24/7 Wall St.

AI-powered longevity research network Rejuve has announced the appointments of Jasmine Smith and Dr Deborah Duong as new CEO and CTO

The SingularityNET spinoff aims to extend the human health span with the aid of voluntarily donated medical data.

The new leadership team at Rejuve will help make the venture commercially available through the Longevity App, which will soon be available on iPhone and Android, allowing users to improve their health span while earning rewards for discounted healthcare products.

Decentralised network Rejuve is a spinoff of SingularityNET, which allows users to create, share, and monetise AI services at scale.

The company aims to extend the human health span as much as possible through research based on voluntarily donated medical data.

Data will be securely tracked through blockchain, with contributors retaining ownership of medical information as well as being granted compensation for supplying data in the form of tokens, redeemable for supplements, DNA test kits or longevity therapies.

New Rejuve CEO Jasmine Smith previously served for years as a community moderator in the SingularityNET ecosystem, her main focus being on transitioning Rejuve from an early-stage research initiative to a commercially available service.

As the new CEO, Smith will be responsible for ensuring growth of the community of data contributors, whose biodata will provide essential information for Rejuves longevity research.

Here is a list of the top chief executive and chief executive officer (CEO) appointments announced throughout tech. Read here

Following the appointment, Smith said: Longevity science is on the edge of amazing breakthroughs, with more funding and research than ever before.

However, longevity research should be a communal endeavour and not a perk for the privileged few. To ensure this, retaining ownership of the medical data we produce is crucial.

Too often, these data are siphoned and sold off before the contributors know it, without them seeing a reward. Longevity programs based on decentralised ownership of medical data, such as Rejuve, are the only way to ensure that the results of longevity research stay open, accessible and decentralised.

Dr Deborah Duong, an AI researcher focusing on computational social science, complex adaptive systems (CAS) and coevolutionary computation, will continue development of a tokenonomy based on non-fungible tokens (NFTs) that guarantee unconditional ownership of products by data and IP donors.

Dr Duong is currently researching emergent social phenomena among AI agents that generate data-driven casual models, as well as blockchain token economics that incentivise social good, bringing 30 years of experience in AI and CAS simulation to Rejuve ten of which have been in healthcare.

Below is a list of the biggest senior technology hires, including chief technology officer (CTO) and chief information officer (CIO) appointments. Read here

I envision the Rejuve ecosystem as the first true economy that uses the principles of decentralised AI to harness the power of social networks into scientific solutions to aging, new Rejuve CTO Duong commented.

This will be possible through a collaboration between decentralised AI and member stakeholders, incentivised to contribute through a just autonomous organisation that guarantees they own the fruits of their labour.

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New CEO and CTO appointed at Rejuve - Information Age

You may have seen some viral videos of extremely fit, white-haired senior citizens working out like they are still in their 20s or 30s.

They can be seen lifting heavy weights or doing pull-ups easily and nimbly, with well-toned and muscular bodies.

Whether they are male or female, it is an impressive feat for people in their 60s and beyond.

Although these individuals seem unusual, the idea of seniors remaining as fit and healthy as their younger counterparts may not be as uncommon in the future, if experts in the field of human longevity are to be believed.

One of these experts include Harvard geneticist Professor Dr David Sinclair, who has been studying the possibility of age reversal in humans for decades.

His bestselling book, Lifespan: Why We Age, and Why We Dont Have To, theorises that ageing is like a disease.

If it is curable, then we might be able to treat it just like any other disease, which could have the biggest impact on human health since antibiotics and public sanitation.

Before going further though, there are questions some of us might ask, e.g. if being able to reverse ageing implies that we will live longer than before, is it natural?

Does it go against our belief systems?

Shouldnt we just accept that humans arent immortal and just allow life to take its natural course?

ALSO READ: Humans can theoretically live forever, but it's a coin toss after 110

But the primary goal of researchers like Prof Sinclair is to improve our quality of life as we age.

Ageing itself isnt a bad thing, but there are disadvantages that come with it, such as increased risk of illnesses, immobility and frailty.

Thus, its much less about chasing a fountain of youth, and more about finding ways to prevent old-age problems that stop seniors from enjoying a full and active lifestyle in their golden years.

Reset to youth

Scientists classify cells as the simplest level of organisation in a living organism.

Ageing, on a cellular level, is often defined as the accumulation of destructive changes caused by changes to gene expression that gradually shift our cells to an aged state.

Based on years of study, researchers believe that they have found some key reasons as to why humans age.

These include a reduction of energy generated by the mitochondria (the power plants inside our cells), the shortening of telomeres (the caps on the end of chromosomes), a loss of stem cells, and an accumulation of so-called senescent cells (non-functioning zombie cells that linger in our skin and tissues).

While genetic reprogramming to regain youthful functions is one avenue of scientific exploration, researchers are also taking inspiration from creatures like the immortal jellyfish Turritopsis dohrnii that can effectively reset its development and revert to a younger stage.

Prof Sinclair believes that maintaining a youthful appearance in old age involves reactivating genes called sirtuins descendants of an ancient survival circuit.

Sirtuins, he claims, are both the cause and the solution to ageing.

These genes can be turned on by modifying your lifestyle, such as intermittent fasting, or by taking dietary supplements that increase NAD+ (nicotinamide adenine dinucleotide) a chemical that plays an integral role in metabolism.

Recently, Prof Sinclair and his team were able to successfully restore the vision of elderly blind mice suffering from a mouse version of glaucoma in their lab by cellular reprogramming to reinstate youthful function and successfully rejuvenate old cells in the mices eyes.

The process used by the scientists Reviver, which stands for recovery of information via epigenetic reprogramming has shown that old tissues can keep a record of youthful epigenetic information that can be accessed for functional age reversal.

That proves that even a complicated organ like the eye can be repaired, polished and made good as new, said Prof Sinclair.

We have no reason to suspect its any different in a human body.

Other developments

Prof Sinclair and his team arent the only ones making breakthroughs in longevity studies.

Here are some other initiatives being made to extend our quality of life:

> Organ regeneration

American biotechnology company LyGenesis has demonstrated that it can grow functional ectopic organs in patients lymph nodes via its organ regeneration technology platform.

In other words, theres a chance that we can get our organs to revert to a normal functioning state should they start to slow or fail.

The companys co-founder Dr Eric Lagasse first demonstrated that allogeneic hepatocytes i.e. genetically and immunologically dissimilar liver cells could re- generate and replace the function of the diseased liver in mice.

The study also showed impressive results in larger mammals, and Dr Lagasse and his team believe the method could ultimately help people with liver diseases.

This means that just one organ donor could potentially help multiple liver disease patients.

> Brain rewiring

The brain has 86 billion neurons, all of which are active.

American neurotechnology company Neurolink has been able to record rat brain activity using thousands of tiny electrodes implanted throughout their brains.

Co-founder Elon Musk has also unveiled a pig with a coin-sized computer chip, which he described as kind of like a Fitbit in your skull with tiny wires.

That might seem like a strange concept, but imagine what the company could do for those suffering from dementia or Parkinsons disease.

If Neurolinks trials with humans are successful, then their devices will be used to help paraplegics operate computers or smartphones with just their mind.

> Measuring biological age

The epigenetic clock refers to the bodys epigenome, which acts as a tracker for changes in DNA (deoxyribonucleic acid) expression.

The tracking enables us to identify a persons biological age, which may be more or less than our chronological age.

Testing for biological age is done by selecting sets of DNA-methylation sites across the genome.

University of California, Los Angeles (UCLA), human genetics and biostatistics professor Dr Steve Horvarth has created the most accurate test to date.

In time, his breakthrough may be instrumental in helping to show that age reversal may be possible.

> Prime editing

Weve reached a point where the discovery of diseases is often conducted at the genome level and a growing number of studies are finding overlap between common and rare human diseases.

This has enhanced our understanding of how diseases develop and may even bring us closer to a cure for all and any diseases.

Now, an advanced form of gene editing is taking another step in that direction.

Prime editing can, in theory, allow researchers to edit more types of genetic mutations than current technology.

In addition to correcting genetic mutations in cells that arent able to divide, prime editing could also be used to manipulate cells that rarely divide, such as those in the nervous system.

In the near future, untreatable neurological diseases like Huntingtons and Parkinsons may even have a cure.

Tips to stay young

OK, so while all these developments are still in their early stages, how do those of us approaching our golden years try to stay youthful right now?

According to Prof Sinclair, the first thing people should do to live longer is to eat less often.

I think the most important thing for increasing healthspan if theres just one thing I could say it would be to eat less often, he said.

Dont eat three meals a day.

He also recommended lifting weights, using biomarker feedback, sleeping well and reducing stress, and eating plants that have been stressed.

(Stressed plants are grown without fertilisers or pesticides, and produce their own defensive compounds, thus consuming these plants may also benefit our own biology.)

Prof Sinclair also shared about several supplements he considers to be longevity molecules or supplements that can help reduce inflammation, help control blood sugar and serve as fuel to power sirtuins.

One of them is resveratrol, which contains a natural compound found in red wine that may help lower blood sugar levels and inflammation.

The second is metformin, a common diabetes drug (doctors may prescribe it off-label for anti-ageing) that helps to control blood sugar levels, while acting like calorie restriction to protect against health problems and prolong life.

Metformin is derived from a medicinal plant called goats rue.

It first received attention when a study from the United Kingdom, involving more than 180,000 people, determined that those whose diabetes was treated with the drug lived notably longer than those who didnt use it.

Newer studies show that it may also have a beneficial effect on heart disease.

The third supplement that Prof Sinclair takes is called nicotinamide mononucleotide (NMN), which converts into NAD+ through a series of chemical reactions.

NAD+, in turn, serves as the most important fuel for sirtuin enzymes and to reverse ageing, increase energy production and brain health, and lengthen telomeres, as well as for chromosome stability and immune cell signalling.

True longevity (or some may like to call it immortality) is still far away.

But institutions all over the world, from the US to Europe and Russia, are making concerted efforts to achieve this goal, and we may be living in the right time to see these developments come to reality.

Datuk Dr Nor Ashikin Mokhtar is a consultant obstetrician and gynaecologist, and a functional medicine practitioner. For further information, email starhealth@thestar.com.my. The information provided is for educational and communication purposes only, and it should not be construed as personal medical advice. Information published in this article is not intended to replace, supplant or augment a consultation with a health professional regarding the readers own medical care. The Star does not give any warranty on accuracy, completeness, functionality, usefulness or other assurances as to the content appearing in this column. The Star disclaims all responsibility for any losses, damage to property or personal injury suffered directly or indirectly from reliance on such information.

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Is it possible to reverse ageing? - The Star Online

Within the first 30 minutes of winning the BT Young Scientist competition last year, Greg Tarr had an offer from a London-based investor wanting to put money into his software project to detect deepfake media.

hat email was shortly followed by a cascade of interest from other investors and employers one offering him a pretty high six-figure sum to come and work for them as an engineer.

It might have seemed like a tough choice for the then Leaving Cert student from Bandon Grammar School in Co Cork, but it was an easy decision to turn it down once he realised he wanted to pursue his dream of becoming an entrepreneur.

Now, almost 12 months on, the 18-year-old has his own company and is a millionaire.

With the 58th BT Young Scientist competition in full swing this week, but again being held virtually for the second year in a row, Greg recalled the moment he found out about his own win.

He said his software could detect deepfake media which is usually a video of a person in which their face or body has been digitally altered so they appear to be someone else, typically used maliciously or to spread false information.

In the moments before he was crowned the winner, he was watching the proceedings with his parents on a screen in his bedroom.

I didnt expect to win at all. I was looking forward to seeing who would because I wanted to hear about what their project was, but it was me, he said.

Greg, who turns 19 this weekend, told the Irish Independent it has been a year of growth for him.

I think I grew up in a month I went from being 17 and having not paid any tax in my life and not having driven a car to owning an American company with an Irish subsidiary, having to find out about tax law and having one million in the bank in that year, he said.

He is now building AI infrastructure the motorways and bridges of the internet as CEO of his company, Inferex, with his dad, Richard Tarr, an engineer and former chief of technology at a data centre, working as head of infrastructure for his son.

Greg said they are currently looking to hire engineers and the firm will be expanding as fast as they can get talented people.

Meanwhile, this years contestants have focused on many tech and societal issues yet to be solved.

Eabha Mills (15), from Heywood Community School in Co Laois, worked with Leah Gilnagh and Madeleine Kavanagh (both 16) to see which sugars improve sports performance best.

They found pineapple gives a slow release of energy compared with the quick boost offered by Jelly Tots.

We now take pineapple at half-time in a hurling match, Eabha said.

A project by Miah OCallaghan (12), from Kinsale Community School, Co Cork, looks at encouraging the adoption of battery hens to help reduce the carbon footprint. His family have rescued 35 hens.

Frustrated with losing so many sliotars during practice, Noah Hill (14), from St Finians College, Co Westmeath, designed his project a device to help retrieve lost sliotars that his local GAA club, Clonkill, has expressed an interest in.

Aoife Duggan (13), from Sandford College, Ranelagh, Dublin, looked into human longevity and found the key to a long and healthy life lies in a joined-up approach to healthcare as well as a good diet and exercise.

See the article here:
BT Young Scientist: A year after Young Scientist win, Greg Tarr (18) runs firm, employs his dad and has a million in the bank - Independent.ie

Have you triedMarvel Unlimitedyet? Its your all-access pass to over 29,000 Marvel comics, available at your fingertips. Download our supercharged app on theApp StoreorGoogle Playtoday!

In 1976, Jack Kirbys ETERNALS introduced a new lineup of gods to the Marvel Universe, a debut that was highly influential. From their first appearances, the Celestials, the Deviants, and the Eternals have been incorporated into the wide Marvel mythos. Their shared story continues in current series ETERNALS (2021), but the signs of the Celestials presence reaches far beyond. Earths Mightiest Heroes transformed the body of a Celestial into Avengers Mountain in AVENGERS (2018), while the space station, Knowhere, was built within a Celestials head. And the Celestials have always kept a close eye on Earth.

To get a better grasp on the link between the Celestials, the Deviants, and the Eternals, Marvel.com takes a look back at their shared history across millennia.

ETERNALS (1976) referred to the Celestials as space gods, but that doesnt mean theyre gods as we define the term. However, they are cosmic beings of immense power whose size and scope defy human perception. They may not be the almighty, but they have directly influenced the course of human history.

ULTIMATES 2 (2016) #6 revealed that the Celestials themselves have a creator: the First Firmament, a living embodiment of the very first universe. The Celestials and their counterparts, the Aspirants, were meant to be the First Firmaments servants. However, the Celestials' desire to allow their own creations to live and evolve led to a devastating war between the Celestials and the Aspirants that left the First Firmament shattered. War usually comes with the picture when it comes to the Celestials.

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The Complete History of the Celestials, the Deviants, and the Eternals - Marvel Entertainment

TRIBECA

Through Jan. 8. R & Company, 64 White Street, Manhattan. 212-343-7979; r-and-company.com.

A 20-year stalwart of Franklin Street, the design gallery R & Company (formerly R 20th Century) expanded in 2018, taking a space on White Street for exhibitions and its considerable design archive. Its latest offering there is a pair of shows connected by saturated color. One is a magnetic group of eight exquisite handblown vessels dating from 1991 to 2011 by the American glass artist Richard Marquis. The other surveys the prolific Danish furniture and interior designer Verner Panton (1926-1998). Marquis was the first outsider to be taught the millefiori or murrine technique carefully guarded for generations by the glassmaking families of Murano. Each piece is a breathtaking world of contrasting hues, translucencies and patterns, including scatterings of snowmen as well as stripes, checks, wood grains and even paint splatters.

Pantons resonant colors and clean geometric shapes personify 60s Pop. This large selection includes his well-known Cone Chair (in wire) and Split-Cone chair, bowllike Easy chair, bulls-eye shag rugs and sundry textiles and light fixtures, most notably the bright orange Flower Pot chandelier. Today, Pantons designs seem more institutional than radical, an effect perhaps of seeing them undiluted rather than as unforgettable high notes in mixed interiors. Exceptions include the 1965 S-chair, which is a curvaceous bentwood version of Gerrit Rietvelds angular Zig-Zag chair (1934); a 1971 coat rack that is a mannequin-like cylinder of red wire painted with a pinched waist and a 1963 sofa in aluminum tubing that toggles between Paul McCobb and Wiener Werksttte. ROBERTA SMITH

Through Jan. 8. Ortuzar Projects, 9 White Street, Manhattan. 212-257-0033; ortuzarprojects.com.

Jacqueline de Jong is the rare artist who engaged with radical politics in her youth and whose work, more than half a century later, still crackles with committed activism. De Jong, a Dutch artist, was associated with the Situationist International, which started in the late 1950s and combined elements of Dada, Surrealism and Marxism to confront postwar capitalism and the burgeoning spectacle of the mass media. Border-Line is her first solo show in New York in more than 50 years; an exhibition surveying her career is currently touring Europe.

At Ortuzar, de Jongs bright paintings filled with jagged figures and forms depict migrants in refugee camps or trying to cross the Mediterranean Sea. Works like Locked In and Out (2021) and Sous Terrain (2021) suggest the horror and dread of migrants caught in deadly situations while the world observes them through the insulated lens of the mass media. (As a teenager, de Jong, who is Jewish, fled from the Nazis.) The Border-Line paintings are drawn with the crude, pre-punk energy of Art Brut, as well as the Belgian artist James Ensor or the Danish artist Asger Jorn (de Jongs erstwhile partner).

In the 1960s, de Jong edited The Situationist Times and participated in a Parisian protest movement that nearly toppled the French government. If young radicals are characterized by their idealism, old ones like de Jong display resilience and longevity as the American activist philosopher Donna J. Haraway reminds us, staying with the trouble rather than running away or retiring from it. MARTHA SCHWENDENER

TRIBECA

Through Jan. 8. Artists Space, 11 Cortlandt Alley, Manhattan. 212-226-3970; artistsspace.org.

Milford Graves was a percussionist who treated drumming as something more expansive than merely establishing a rhythm or tempo. Graves, who died this year, was also a botanist and herbalist, a professor at Bennington College, a cardiac technician, a visual artist. Percussion connected with the human heartbeat and the energy flowing through plants, and made its way into art objects, as you can see in Fundamental Frequency at Artists Space, easily one of the best shows in town right now.

Gravess sculptures, assemblages and diagrammatic drawings are the most visually captivating. His Yara Training Bag, from around 1990, incorporates painted boxing gloves, punching bags, a samurai sword and an acupuncture model elements from Yara, Gravess invented martial art form. Other sculptures include gongs, tribal sculptures, medical and astronomical diagrams, videos and printouts of electrocardiogram readings.

This show follows a survey at the ICA Philadelphia (and an excellent documentary, Milford Graves Full Mantis, from 2018). The gallery handout includes Gravess Herbal Chart, detailing the effects of various herbs on the human body. All these elements combined offer an excellent introduction to Gravess remarkable practice and worldview, in which art, medicine, plants, human perception, the nervous system and the cosmos are all connected. MARTHA SCHWENDENER

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Art We Saw This Winter - The New York Times

In September 2021, Amazon founder Jeff Bezos invested in longevity biotech startup, Altos Labs putting the spotlight on the field of anti-ageing. Pharma and biotech firms are investing in research that could prevent and reverse the ageing process in humans, but can novel therapies actually provide longevity? Let's find out.

Ageing is mostly associated with skin conditions like wrinkles, crows feet etc., and anti-ageing is considered a purview of the cosmetic industry, but its a much more complicated physiological process at a cellular and metabolic level categorised by telomere length, inflammation, oxidative stress, and slower cell metabolism.

While ageing isnt considered a disease or condition per se, companies are looking at bodily processes at the cellular level to see how ageing progresses and trying to find the right treatments that might slow these processes down.

Anti-ageing drug research

It is incredibly difficult to develop a single drug that can cure ageing not only because of the complexity, but because it shares similar traits - at a cellular level, with other age related diseases like cancer and neurodegenerative disorders.

Thats why many of the firms studying age-related diseases like cancer and Alzheimers are now collaborating with researchers looking at ageing more broadly and vice versa.

Metformin is the most promising anti-ageing drug candidate that is approved by the United States Food and Drug Administration (USFDA). The drug has been used successfully to treat diabetes for over 60 years. Studies have already shown that Metformin can delay ageing in animals. It may also influence fundamental ageing factors that underlie multiple age-related conditions in humans.

The Targeting Aging with Metformin (TAME) Trial, managed by the American Federation for Aging Research (TAFR), is testing whether those taking metformin experience delayed development or progression of age-related chronic diseasessuch as heart disease, cancer, and dementia.

Earlier studies found that people with type 2 diabetes who take metformin have lower death rates. Researchers have also observed that COVID-19 patients taking the drug had less hospitalisations and death rate.

Another drug being repurposed for anti-ageing studies is rapamycin. Rapamycin was initially discovered as an anti-fungal metabolite. Subsequently, rapamycin was found to possess immunosuppressive and anti-proliferative properties in mammalian cells, spurring an interest in identifying the mode of action of rapamycin.

It is the only pharmacological agent thus far shown to reproducibly extend lifespan and delay a subset of age-associated pathologies in multiple strains of mice. Swiss firm Novartis is researching rapamycin and its analog, everolimus, for potential anti-ageing effects in humans.

One of the most popular areas of research is around senolytics a class of drugs that target ageing (or senescent) cells and destroy them via induced cell death.

In 2018, US based startup Unity Biotechnology started the first human trial of its senolytic drug UBX0101.

In 2019, US Mayo Clinic published the positive results of its pilot study using dasatinib (cancer drug) and quercetin (cardiovascular drug) in combination as senolytics to treat idiopathic pulmonary fibrosis. This was a small pilot study that points to feasibility of larger trials in age-related diseases.

Can pharma cure ageing?

Despite all the positive news and interest, anti-ageing is still at a nascent stage. Majority of the research currently being done is at a preclinical stage, it would be years, if not decades before we know drugs are a viable option to ageing or not.

We have seen tremendous interest in the anti-ageing space in the past six months that actually aligns with discoveries that happened about 25 years ago. Since discovering that ageing is a biological process, researchers have been conducting studies and publishing reports on what this means in practice. Some of these findings are gaining significant traction and reach human trial stages, which is likely the source of this renewed interest in the field. More researchers looking at ageing means a higher probability of having treatments ready for human trials and market entry, said Garri Zmudze, Executive Coordinator of the Longevity Science Foundation, Switzerland.

The Longevity Science Foundation is a Swiss non-profit organisation advancing the field of human longevity by funding research and development of medical technologies to extend the healthy human lifespan.

No single treatment or medicine will stop the bodys ageing or reverse all age-related conditions.

'While there may never be a definitive cure for ageing, we believe there are promising findings that can help us reconceptualise what ageing looks like in our lifetimes. In addition to the drugs/treatments, ageing interventions like nutrition and exercise show a lot of promise in increasing lifespan and health-span; we just need to figure out exactly which forms are most effective, said Garri.

Therapies to treat the hallmarks of ageing have already begun. A cure for ageing will be arrived at gradually, step by step, as we tackle the various aspects of this multifaceted process and do so better and better.

It will likely not be a single cure but a collection of therapies to address different aspects of ageing: telomere attrition, accumulation of senescent cells, mitochondrial mutation, extracellular and intracellular waste products, extracellular matrix stiffening and more. It will involve stem cell therapy, gene therapy, organ printing and replacement, supplements like NAD (nicotinamide adenine dinucleotide) and epigenetic clocks that help alter erroneous information that has arisen with time, said a spokesperson from BioViva, who dont want to be named. BioViva USA Inc is dedicated to improving healthy human longevity through gene therapy.

Regulatory challenges

Ageing is not yet classified as a disease by the FDA and other regulatory agencies and until then, there is a lack of context and regulatory support for such research.

How close we are to a treatment will also depend on grass-root movements that force regulatory bodies to change their endpoints from the diseases of ageing - like diabetes type 2, dementia etc. - to ageing itself as a disease. The regulatory bodies do not regard ageing as a disease and therefore do not fund cures for it. They fund cures for amyloid plaques but not research for the condition that causes amyloid plaques in the first place. Only grass-root movements can change the endpoints of the regulatory bodies. In other words, a cure for ageing requires people to understand that ageing can be cured, and therefore to demand that the old regulatory system adapts to current capabilities, said a spokesperson from BioViva.

Garri feels there are other challenges to overcome before we think about regulatory ecosystem for such research.

Right now, the key barrier in advancing longevity science is the lack of transparent, equity-free funding for early-stage longevity tech. Much of this tech is not yet eligible for venture funding but needs capital to define a distinguishable therapy/product. This is a fundamental challenge in developing treatments; until it is overcome, regulatory barriers will be a problem that we will need to address in the future when specific treatments are ready for international introduction, said Garri.

The global anti-ageing market is predicted to skyrocket from around $191.5 billion in 2019 to a whopping $421.4 billion by 2030, according to a report by P&S Intelligence. As the research evolves, there will be a better understanding of the science of ageing and longevity. All this will open a new frontier and will certainly translate to a better and healthier life.

Ayesha Siddiqui

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Seeking the 'Fountain of Youth' - BSA bureau

St. Lukes Parish is found in Church Hill, Maryland. Its parishioners are proud of their church, for its age, its beauty, and for the fellowship shared there.

St. Lukes was founded in 1728 and is constructed of brick. I think of these bricks, and the many country folk who have passed through the doors, sat in the pews, and who have offered up their prayers and worship within the space defined by these bricks. These are surely special bricks, due to the multitude who have silently shared their best and their worst.

When people talk of church, they may be speaking of the tangible structure, the image found on Christmas cards. Or alternatively, they may be speaking of the intangible church; the gathering for sharing a common purpose.

I recall the words of Jesus, that He would rebuild a destroyed church in just three days time. He was speaking of the three days He would spend in the grave, and referring to an intangible church, with its all so real and growing congregation of the faithful.

I ponder the significance of these bricks, the mortar that binds them, and the intangible church.

First, to the bricks. Bricks serve as building blocks; they are sourced from clay, shaped in molds, and fired in furnaces. Although their origin is lowly, their destiny may be highly honorable. Like rocks they are strong, well suited for their purpose and are long lasting. When joined, bricks can build just about anything, from walkways to cathedrals.

I think people are very much like bricks. They too are sourced from humble beginnings.

In his story of creation, Moses equates the origin of people to that of dust. People are shaped by nature and nurture, and the extremes of this life are at times as hot as a furnace. Whats important is less to do with the experiences we have had, and more to do with how we react to them. If we keep focus on our purpose, then chances are good that we may become dependable building blocks and can be of great utility to the builder, our creator, and to each other.

The builder carefully selects his bricks.

Now to the mortar. Mortar serves as glue; it holds things together and permits bricks to take shape. Its the quality of mortar to maintain its adhesion for extended periods of time. Mortar makes bricks functional so to yield the realization of the builders vision. Without mortar, there is just a pile of bricks.

I think mortar may be very much like the Holy Spirit. It is this spirit that draws people, permits them to join, stay together, take shape, and serve the purpose-filled vision of the builder. What is this substance that serves as glue?

I find the Holy Spirit very challenging to conceptualize. Some refer to this spirit as the Holy Ghost. When I think of ghosts, I think of the dead. But my lifes journey has proven to me that our God is a living God. So again, I look to the Word, to help me add shape to this ghost.

The most recurring term found was love.

In Pauls letter to Corinth, he attempted to clarify. I filtered it down to charity the giving of ones self. I think this may be Gods giving of Himself true charity from a true God, to give without reservation, expectation, or limitation.

Other terms found include Wonderful Counselor; Dwelling in us; Working in us; Our peace; Our advocate; Equipping us; Providing us angels; Leading us in the way we should go; Anointing us for service; Giving us revelation knowledge; A rewarder of those who diligently seek Him.

So, I found several terms attributable to the Holy Spirit, but I like the simplest one the best. The Holy Spirit is the love of God. And as with people, love cant be seen, but the evidence of loves presence can be very tangible. Although the Holy Ghost is not seen, the evidence of its adhesive qualities is readily apparent.

The intangible church is the result of the adhesion of human spirits by the love of God. The tangible church is the bricks held together by the mortar consistent with the vision and purpose of the builder.

What is that purpose? The answer I found in St. Matthews gospel, For where two or three are gathered together in my name, there I am in the midst of them. I am. The great I Am found in the midst of those who gather. That is the purpose for the mortar to bind the bricks.

In my family, the members are held together by a strong matriarch. Initially it was my great-grandmother, then it was my grandmother who served as the glue, and now it has passed to my mother. When cupboards were empty, and when cupboards were full. Through global events and personal tragedies. I thank God for the glue that holds families together, and for the mortar that binds bricks allowing churches to stand for hundreds of years so that thousands of people may share the presence of the great I Am.

The beauty and longevity of assembled bricks is due to the adhesive quality of the mortar. Just as the shape, strength, and longevity of human relationships is due to the love that holds them together. Perhaps all people should work towards becoming chosen bricks. And to look for the mortar that binds for purpose.

Bobby Gallion grew up in the northern part of Queen Annes County, attended schools there and has been a parishioner at St. Lukes for 30 years.

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Of Bricks and Mortar | | news-journal.com - Longview News-Journal

St. Lukes Parish is found in Church Hill, Maryland. Its parishioners are proud of their church, for its age, its beauty, and for the fellowship shared there.

St. Lukes was founded in 1728 and is constructed of brick. I think of these bricks, and the many country folk who have passed through the doors, sat in the pews, and who have offered up their prayers and worship within the space defined by these bricks. These are surely special bricks, due to the multitude who have silently shared their best and their worst.

When people talk of church, they may be speaking of the tangible structure, the image found on Christmas cards. Or alternatively, they may be speaking of the intangible church; the gathering for sharing a common purpose.

I recall the words of Jesus, that He would rebuild a destroyed church in just three days time. He was speaking of the three days He would spend in the grave, and referring to an intangible church, with its all so real and growing congregation of the faithful.

I ponder the significance of these bricks, the mortar that binds them, and the intangible church.

First, to the bricks. Bricks serve as building blocks; they are sourced from clay, shaped in molds, and fired in furnaces. Although their origin is lowly, their destiny may be highly honorable. Like rocks they are strong, well suited for their purpose and are long lasting. When joined, bricks can build just about anything, from walkways to cathedrals.

I think people are very much like bricks. They too are sourced from humble beginnings.

In his story of creation, Moses equates the origin of people to that of dust. People are shaped by nature and nurture, and the extremes of this life are at times as hot as a furnace. Whats important is less to do with the experiences we have had, and more to do with how we react to them. If we keep focus on our purpose, then chances are good that we may become dependable building blocks and can be of great utility to the builder, our creator, and to each other.

The builder carefully selects his bricks.

Now to the mortar. Mortar serves as glue; it holds things together and permits bricks to take shape. Its the quality of mortar to maintain its adhesion for extended periods of time. Mortar makes bricks functional so to yield the realization of the builders vision. Without mortar, there is just a pile of bricks.

I think mortar may be very much like the Holy Spirit. It is this spirit that draws people, permits them to join, stay together, take shape, and serve the purpose-filled vision of the builder. What is this substance that serves as glue?

I find the Holy Spirit very challenging to conceptualize. Some refer to this spirit as the Holy Ghost. When I think of ghosts, I think of the dead. But my lifes journey has proven to me that our God is a living God. So again, I look to the Word, to help me add shape to this ghost.

The most recurring term found was love.

In Pauls letter to Corinth, he attempted to clarify. I filtered it down to charity the giving of ones self. I think this may be Gods giving of Himself true charity from a true God, to give without reservation, expectation, or limitation.

Other terms found include Wonderful Counselor; Dwelling in us; Working in us; Our peace; Our advocate; Equipping us; Providing us angels; Leading us in the way we should go; Anointing us for service; Giving us revelation knowledge; A rewarder of those who diligently seek Him.

So, I found several terms attributable to the Holy Spirit, but I like the simplest one the best. The Holy Spirit is the love of God. And as with people, love cant be seen, but the evidence of loves presence can be very tangible. Although the Holy Ghost is not seen, the evidence of its adhesive qualities is readily apparent.

The intangible church is the result of the adhesion of human spirits by the love of God. The tangible church is the bricks held together by the mortar consistent with the vision and purpose of the builder.

What is that purpose? The answer I found in St. Matthews gospel, For where two or three are gathered together in my name, there I am in the midst of them. I am. The great I Am found in the midst of those who gather. That is the purpose for the mortar to bind the bricks.

In my family, the members are held together by a strong matriarch. Initially it was my great-grandmother, then it was my grandmother who served as the glue, and now it has passed to my mother. When cupboards were empty, and when cupboards were full. Through global events and personal tragedies. I thank God for the glue that holds families together, and for the mortar that binds bricks allowing churches to stand for hundreds of years so that thousands of people may share the presence of the great I Am.

The beauty and longevity of assembled bricks is due to the adhesive quality of the mortar. Just as the shape, strength, and longevity of human relationships is due to the love that holds them together. Perhaps all people should work towards becoming chosen bricks. And to look for the mortar that binds for purpose.

Bobby Gallion grew up in the northern part of Queen Annes County, attended schools there and has been a parishioner at St. Lukes for 30 years.

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Of Bricks and Mortar | | kilgorenewsherald.com - Kilgore News Herald