Category Archives: Genome

The B+ Foundation
The Andrew McDonough B+ Foundation was born out of tragedy after athlete and #39;A #39; student Andrew McDonough passed away from complications of leukemia on July 14th 2007, at age 14. Andrew #39;s blood type and the family #39;s motto was, and continues to be, "B+"... "Be Positive". The overall goal of The B+ Foundation is to "Do Good." Our primary objectives are: - Sponsor research to find cures for pediatric cancers and improved treatment protocols. In 2011, we awarded $270000 in research grants and in the first half of 2012, we awarded a $140000 research grant to the Pediatric Cancer Genome Project at St. Jude. - Provide assistance to families of children with cancer nationwide. In 2011 alone, we provided over $500000 to families. -Keep the B+ Mission alive! Andrew taught us to have fun, show affection, set goals and try our best, appreciate all the blessings that we have, and to keep our lives in perspective. And, to make time for our loved ones. In short, we need to Live Like Andrew. For more information visit http://www.BePositive.orgFrom:livelikeandrewViews:0 0ratingsTime:02:32More inNonprofits Activism

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CRYPTOZOOLOGY ONLINE: On The Track (Of Unknown Animals) Episode 63
The latest episode of our monthly webTV show from the CFZ and CFZtv, bringing you news on our activities within cryptozoology and natural history as well as the latest cryptozoological, and monster hunting news from around the world. I can #39;t believe that we have done this every month for five years now - 63 episodes. Golly! This episode brings you: CFZ in winter Winter waders birdwatching on Northam burrows The Crypto Community Blogging Lynx in Poland Bobcat in California Unicorns in the press Bigfoot genome? Bufo melanosticus (Chinese toads) Mystery anurans Mystery cichlids Corinna looks at out of place birds New and Rediscovered: New weta New and Rediscovered: New hermit crab New and Rediscovered: Giant tortoise Happy ChristmasFrom:cfztvViews:9 0ratingsTime:39:43More inScience Technology

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CRYPTOZOOLOGY ONLINE: On The Track (Of Unknown Animals) Episode 63 - Video

Jonathan Sarfati - Does our DNA show that we came from apes?
Jonathan Sarfati from Creation Ministries International explains why our DNA similarity with apes points to a common designer and not evolution. creation.com Related Articles What about the similarities between ape and human DNA? Does this support evolution?: creation.com Decoding the dogma of DNA similarity: creation.com Chimp genome sequence very different from man: creation.com Related Products: The Greatest Hoax on Earth? Refuting Dawkins on evolution - creation.com By Design book - creation.com Refuting Evolution book - creation.com Refuting Compromise Updated Expanded book - creation.comFrom:YahuworthyisthelambViews:12 1ratingsTime:01:05More inEducation

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Jonathan Sarfati - Does our DNA show that we came from apes? - Video

Gymnosperm evolution.mp4
For more information, log on to- shomusbiology.weebly.com Download the study materials here- shomusbiology.weebly.com There are between 800 and 900 extant or currently living species of Gymnosperms. It is widely accepted that the gymnosperms originated in the late Carboniferous period.[5] This appears to have been the result of a whole genome duplication event around 319 million years ago.[6] Early characteristics of seed plants were evident in fossil progymnosperms of the late Devonian period around 380 million years ago. It has been suggested that during the mid-Mesozoic era, pollination of some extinct groups of gymnosperms were by extinct species of scorpionflies that had specialized proboscis for feeding on pollination drops. The scorpionflies likely engaged in pollination mutualisms with gymnosperms, long before the similar and independent coevolution of nectar-feeding insects on angiosperms.[7][8] Conifers are by far the most abundant extant group of gymnosperms with six to eight families, with a total of 65-70 genera and 600-630 species (696 accepted names).[9] Conifers are woody plants and most are evergreens.[10] The leaves of many conifers are long, thin and needle-like, others species, including most Cupressaceae and some Podocarpaceae, have flat, triangular scale-like leaves. Agathis in Araucariaceae and Nageia in Podocarpaceae have broad, flat strap-shaped leaves. Cycads are the next most abundant group of gymnosperms, with about 130 species. The other ...From:Suman BhattacharjeeViews:0 0ratingsTime:31:48More inEducation

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Gymnosperm evolution.mp4 - Video

Research into Detection of De Novo Mutations and Fetal Trisomies
Learn more at http://www.lifetechnologies.com Identification of a single missense de novo mutation in ABCC9, a potassium channel which is causative of Cantu syndrome, a rare musculoskeletal/cardiac disorder. This discovery was made using trio exome sequencing on the SOLiD 5500 genetic analyzer. The discovery has led to greater understanding of the molecular etiology, and potential treatments for this syndrome. The talk also describes a fast whole genome sequencing analysis method to detect fetal trisomies non-invasively from maternal blood samples.From:LifeTechnologiesCorpViews:0 0ratingsTime:13:42More inScience Technology

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Research into Detection of De Novo Mutations and Fetal Trisomies - Video

Automated Bacterial Genome Closure Webinar
In this webinar, DNASTAR #39;s Matt Keyser shows you how to assemble a novel strain of bacteria using a closely related reference sequence. The webinar includes a demonstration of how to select an appropriate reference using SeqMan NGen and then how to align against that template and use SeqMan Pro to automatically resolve the majority of structural variations and gaps.From:DNASTARIncViews:9 0ratingsTime:56:03More inScience Technology

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Automated Bacterial Genome Closure Webinar - Video

HTC Droid DNA First Senseless Rom GeNome [FULL REVIEW] and Install
DroidModderX.com http Twitter @DroidModderX Grab the Rom files here: wp.me Buying Something Use This Link to Support DroidModderX.com goo.gl SUBSCRIBE to this channel for more coverage on the Droid DNA and other devices like the Galaxy Note II, Galaxy S III, Nexus 10, Galaxy Nexus and more! http://www.youtube.com Be sure to Click the ThumbsUp Video It helps me more than you know! So here it is the very first Senseless Rom for the HTC Droid DNA. It runs nice and fast. All of the bloat has been removed. There is not a ton of custom features, but keep in mind this is just the base of the Rom that is to come!From:DroidModd3rXViews:5 0ratingsTime:07:06More inScience Technology

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CARLSBAD, Calif., Dec. 6, 2012 /PRNewswire/ -- Whole genome sequencing has revealed previously unreported mutations in metastatic triple-negative breast cancer (TNBC), according to a study published by the journal Molecular Cancer Therapeutics.

The study, "Genome and transcriptome sequencing in prospective triple negative breast cancer uncovers therapeutic vulnerabilities," was sponsored by the Translational Genomics Research Institute (TGen) and US Oncology Research with support fromLife Technologies Corporation (LIFE) and is currently available online.

"The study underscores the potential clinical utility of genomic sequencing to improve cancer care," said Paul Billings, M.D., Ph.D., chief medical officer at Life Technologies. "Our hope is that in the not too distant future, sequencing will become available to many more patients and physicians."

In a sample of 14 tumors from ethnically diverse metastatic TNBC patients, the researchers found significant mutations and other changes in more than a dozen genes through whole-genome sequencing performed on Life Technologies' Applied Biosystems SOLiD 4.0 platform. The most frequently mutated gene among the tumors (seven of 14) was the TP53 tumor suppressor, and aberrations were observed in additional tumor suppressor genes including CTNNA1, which was detected in two of six African-American patients (who typically have more aggressive and treatment-resistant disease). Alterations were also seen in the ERBB4 gene, known to be involved in mammary-gland maturation during pregnancy and lactation, but not previously linked to metastatic TNBC.

The study included an "outlier analysis," which assessed expression patterns for each tumor when compared against the other tumors examined in the study. Specific cancer genes overexpressed among tumors in the study's cohort included: ALK, AR, ARAF, BRAF, FGFR2, GLI1, GLI2, HRAS, HSP90AA1, KRAS, MET, NOTCH2, NOTCH3, and SHH. Significantly underexpressed cancer genes included: BRCA1, BRCA2, CDKN2A, CTNNA1, DKK1, FBXW7, NF1, PTEN, and SFN.

Each tumor was genomically unique, but nine of the 14 contained alterations in one or both of two particular cellular pathways: RAS/RAF/MEK/ERK and PI3K/AKT/MTOR.

"Genome sequencing will eventually become a standard tool for oncologists," said Billings, "allowing them to tailor therapies to the unique genetic profiles of each of their patients."

Metastatic TNBC is a highly aggressive form of breast cancer that disproportionately affects African-Americans. It is called triple-negative because tumors do not express the estrogen receptor, progesterone receptor or HER-2, the biomarkers successfully targeted in most breast cancers.

Metastatic TNBC also has a poor prognosis once the cancer has spread to other organs, with a median survival rate among metastatic patients of only one year. While TNBC accounts for only about 15 percent of all breast cancers, its more aggressive biology makes it responsible for nearly one in four deaths related to this disease.

The SOLiD 4.0 is For Research Use Only. Not for use in diagnostic procedures.

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Whole Genome Sequencing of Triple Negative Breast Cancer Reveals Previously Unreported Mutations

Pathway and Network Analysis of Somatic Mutations Across Cancer Types in TCGA - Ben Raphael
November 27-28, 2012 - The Cancer Genome Atlas #39; 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA More: http://www.genome.govFrom:GenomeTVViews:4 0ratingsTime:17:22More inScience Technology

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Pathway and Network Analysis of Somatic Mutations Across Cancer Types in TCGA - Ben Raphael - Video

Adverse Outcomes in Clear Cell Renal Cell Carcinoma With Mutations ... - Ari Hakimi
November 27-28, 2012 - The Cancer Genome Atlas #39; 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA More: http://www.genome.govFrom:GenomeTVViews:3 0ratingsTime:14:34More inScience Technology

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Adverse Outcomes in Clear Cell Renal Cell Carcinoma With Mutations ... - Ari Hakimi - Video