Category Archives: Genetic Engineering

PUBLIC RELEASE DATE:

25-Sep-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, September 25, 2014The staggering growth rate of the global population demands innovative and sustainable solutions to increase food production by as much as 70-100% in the next few decades. In light of environmental changes, more drought-tolerant food crops are essential. The latest technological advances and future directions in regulating genes involved in stress tolerance in crops is presented in a Review article in OMICS: A Journal of Integrative Biology, the peer-reviewed interdisciplinary journal published by Mary Ann Liebert, Inc., publishers. The article is available free on the OMICS website.

Coauthors Roel Rabara and Paul Rushton, Texas A&M AgriLife Research and Extension Center, Dallas, TX, and Prateek Tripathi, University of Southern California, Los Angeles, focus on the role of transcription factors, described as "master regulators" because they are important components of many genetic regulatory pathways and may be able to control clusters of genes. Drought tolerance is a complex trait that is regulated by multiple genes.

In the article "The Potential of Transcription Factor-Based Genetic Engineering in Improving Crop Tolerance to Drought," the authors describe current strategies for using transcription factors to improve drought tolerance and discuss how novel, advanced technologies will help study promising, genetically engineered food crops under field growing conditions.

"With limited water supply continuing to constrain food crop production, understanding and improving crop tolerance to drought is a grand challenge for 21st century biology and medicine, and to feed a massive world population," says OMICS Editor-in-Chief Vural zdemir, MD, PhD, DABCP, Gaziantep University, Faculty of Communications and Office of the President, Gaziantep, Turkey, and Co-Founder, the Data-Enabled Life Sciences Alliance International (DELSA Global), Seattle, WA. "Transcription factors are veritable candidates for innovation in the next generation of transgenic crops because of their natural role in plant growth and development. Field studies (not only greenhouse measures) will provide additional insights to measure their actual impact and innovation. This state of the art review article offers a timely analysis and topline summary distilled from the past several decades of leading literature."

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About the Journal

OMICS: A Journal of Integrative Biology is an authoritative peer-reviewed journal published monthly online, which covers genomics, transcriptomics, proteomics, metabolomics, and multi-omics innovations. The Journal explores advances in the era of post-genomic biology and medicine and focuses on the integration of OMICS, data analyses and modeling, and applications of high-throughput approaches to study biological problems. Social, ethical, and public policy aspects of the large-scale biology and 21st century data-enabled sciences are also considered. Complete tables of content and a sample issue may be viewed on the OMICS website.

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Can genetic engineering help food crops better tolerate drought?

Robert Priest_Idea For Genetic Engineering

By: Linda Stitt

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Robert Priest_Idea For Genetic Engineering - Video

TIME Ideas Science If Synthetic Biology Lets Us Play God, We Need Rules MOLEKUULBrand X/Getty Images

Zocalo Public Square is a not-for-profit Ideas Exchange that blends live events and humanities journalism.

Synthetic biology has been called genetic engineering on steroids. Its also been described as so difficult to pin down that five scientists would give you six different definitions. No matter how this emerging field is characterized, one thing is clear: the ability to synthesize and sequence DNA is driving scientific research in brand-new and exciting directions.

In California, scientists have created a breakthrough antimalarial drugbakers yeast made in a lab that contains the genetic material of the opium poppy. The drug has the potential to save millions of livesand to ensure drug production that independent of poppy flowers. At MIT, researchers are working on a way for plants to fix their own nitrogen, so farmers will no longer need to use artificial fertilizers. And, in the far future, scientists and NASA researchers are looking to create a digital biological teleporter to bring to Earth life forms detected on Mars via a sort of biological fax.

What should we worrying about in this moment of tremendous, and potentially cataclysmic, scientific discovery? In advance of the Zcalo/Arizona State University event How Will Synthetic Biology Change the Way We Live?, we asked experts the following question: Soon well be able to program DNA with the same ease we program computers. What new responsibilities will be imposed on us?

1) Stepping ahead of technology to imagine the world we want to live in

Synthetic biology sees life as an engineering project a repertoire of processes that can be reprogrammed to produce technologies and products. It envisions powerful new tools for constructing biological parts. Many in synthetic biology celebrate technologies like automated DNA synthesis as agents of democratization, potentially allowing easy and widespread access to custom-made DNA. According to their vision, these technologies will enable bioengineers to freely experiment with living systems, accelerating progress in innovation and producing enormous benefits for society.

But there are risks. The question is often raised: How can we prevent these technologies from falling into the wrong hands? DNA synthesis machines cannot distinguish between tinkerers and terrorists. Though this question is crucially important, it is revealing for what it leaves unasked. Why are synthetic biologys tinkerers presumed to be the safe hands for shaping the technological future? Why do we defer to their visions and judgments over those that we collectively develop?

We tend to focus governance not on projects of innovation, but on how resulting technologies might be used in society. By attending primarily to technologys misuses, impacts, and consequences, we confine ourselves to waiting until new problemsand responsibilitiesare imposed upon us. Science is empowered to act, but society only to react. This leaves unexamined the question of who gets to imagine the future and, therefore, who has the authority to declare what benefits lie ahead, what risks are realistic, and what worries are reasonable and warrant public deliberation?

Our imaginations of the future shape our priorities in the present. It is a task of democracy, not science, to imagine the world we want to live in. Genuine democratization demands that we embrace this difficult task as our own, rather than wait to react to the responsibilities that emerging technologies impose upon us.

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If Synthetic Biology Lets Us Play God, We Need Rules

With genetically engineered therapies for the infectious disease, Ebola, currently undergoing testing for safety and efficacy, GMO Answers is highlighting the use of genetic engineering in other biomedical applications. The posts author, Richard Green, also looks at whyGMOs, though used in both agriculture and medicine, are more controversial in agricultural applications.

The technology of genetic modification orgenetic engineeringwas first developed in the early 1970s, commercialized in pharmaceutical applications in the early 1980s, and then agricultural applications in the early 1990s.

The technology has been around for 40 years. It is hardly new. Perhaps if you compare it to the internal combustion engine it is new, but compared to something as recent and ubiquitous as flat screen HDTVs, DVRs, andWi-Fi-friendly touch screen devices like iPhones and Tablets, it is a time tested technology.

In medicine,genetic engineering(GE) is used to make biopharmaceutical drugs. Various organisms are engineered for use as factories to produce the drug product.Bacteriaare the preferred option, as they are the easiest to grow and scale-up for production, but depending on the complexity of the drugs molecular structure, other organisms such as yeasts, mammalian cells,etc., can also be used toexpressthe drug product. The first GE drug approved for use wasinsulin. By the year 2000, there were over100GE drugs on the market. Currently, peoples lives are changed every day by drugs likeRemicade,Epo,Avastin, andNeulasta

Whilegenetic engineeringis used in both agriculture and medicine, it is far more controversial in agriculture. Here is an explanation that helped shape my point of view: intellectually, I can grasp that adding or silencing a few well-characterizedgenesout of thousands is a drop in thegenomebucket, but for me it makes it a bit more real to think of it in terms of people. Just look at the variety among us. Variations between our thousands ofgenesare why we are all different from each other, but even with those differences, we are all human. It is similar with plants. Changing one, or as we get better, a few genes, in the plantgenomeis barely a blip compared to the normal diversity between individuals. To paraphrase what a wise man once said,GE corn is just corn.

We encourage you to visit our GMO Answers site and read GMOs in Food and Medicine: An Overview in its entirety.

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GMO Answers Provides an Overview of GMOs in Medicine

8 hours ago Before (top) and after (bottom) images of gold nanoprobe tests. In DNA samples containing no genetic variations, the pink solution became colorless within 10 minutes. Credit: A*STAR Institute of Bioengineering and Nanotechnology

Tests for identifying genetic variations among individuals, which can be used to develop precisely targeted drug therapies, are a current focus in the emerging field of pharmacogenomics. A*STAR researchers have now developed and patented a customized and elegant nanoprobe for assessing sensitivity to the drug warfarin.

To develop the nanoprobe, Jackie Ying at the A*STAR Institute of Bioengineering and Nanotechnology and co-workers in Singapore, Taiwan and Japan devised a relatively simple procedure that uses standard laboratory equipment and can be easily adapted for other genetic tests.

"Our method is faster, more cost-effective and more accurate than existing alternatives," says Ying.

Ying's method detects genetic variations known as single-nucleotide polymorphisms (SNPs) that differ in only a single-nucleotide building block of DNA. In the case of warfarinthe most frequently prescribed anticoagulantthere are SNP differences in specific parts of the genome that indicate whether a patient will tolerate the drug or suffer serious side effects.

The researchers used gold nanoparticles attached to short sections of DNA that bind to specific complementary sequences of DNA through the base pairing that holds together double-stranded DNA. These nanoprobes were exposed to fragments of DNA that had been cut out and amplified from a patient's genome.

The nanoprobes are initially pink due to surface plasmonic effects involving ripples of electric charge. When analyzed, if the probes do not bind to the DNA fragments, they aggregate and become colorless on exposure to a salt solution. If they do bind to the target, they will not aggregate but will remain pink until heated to a 'melting temperature' at which the base pairing is disrupted and the DNA strands of the probe and the genome fragments separate. For cases of partial complementarityin which the fragments are mismatched by a single nucleotidethe melting temperature is lowered by an amount depending on the level of mismatch. This allows SNPs to be detected through their different melting temperatures.

The resulting color change is easily visible to the human eye but can also be evaluated automatically (see image). The system can also distinguish between homozygous genotypes (where a person caries the same SNP on each member of a pair of chromosomes) and heterozygous genotypes (where a person carries different SNPs on each chromosome).

"The patented warfarin test kit is available for commercialization or licensing," says Ying. "We have developed and are validating assay kits for several other applications in pathogen detection, pharmacogenomics and genetic disease screening."

Explore further: Using gold nanoprobes to unlock your genetic profile

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Gold nanoparticles linked to single-stranded DNA create a simple but versatile genetic testing kit

PUBLIC RELEASE DATE:

23-Sep-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, September 23, 2014New technology and better screening strategies can lower the rate of false-positive results, which impose a substantial financial and psychological burden on women. The many misperceptions about breast cancer screening options and risks, the benefits and costs of screening, and the need for new approaches and better education are discussed in a series of articles in a supplement to Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The supplement is available free on the Journal of Women's Health website at http://online.liebertpub.com/toc/jwh/23/S1.

In the article "The Patient Burden of Screening Mammography Recall," the authors report that among more than 1.7 million women aged 40-75 years who underwent screening mammography and were not diagnosed with breast cancer, 15% were recalled for further testing. The cumulative risk of a false-positive result after 10 years of annual screening mammograms is an estimated 61%. Coauthors Matthew Alcusky, PharmD, MS, Janice Clarke, RN, BBA, and Alexandria Skoufalos, EdD, Jefferson School of Population Health; Liane Philpotts, MD, FSBI, Yale University School of Medicine; and Machaon Bonafede, PhD, MPH, Truven Health Analytics, evaluate the direct cost burden of recall, the indirect costs associated with missed work time, travel, and substitute caregivers, for example, and the physical or psychological effects of a false-positive result, which may include unnecessary anxiety and reduced quality of life.

In an accompanying review article on "Understanding Patient Options, Utilization Patterns and Burdens Associated with Breast Cancer Screening," authors Susan C. Harvey, MD, Johns Hopkins Medical Institutions; Sharon Mass, MD, FACOG, Morristown Obstetrics and Gynecology Associates; and Ashok Vegesna, PharmD, Janice Clarke, RN, BBA, and Alexandria Skoufalos, EdD, Jefferson School of Population Health, attribute much of the confusion women face in making informed decisions about breast cancer screening and recall options to a lack of consensus among the organizations developing screening guidelines and the mixed messages they deliver. The authors call for a more thoughtful approach to breast cancer screening and research that takes into account the tangible and intangible costs that women now bear.

"The articles in this supplement are timely and reveal surprisingly complex issues," says Susan C. Harvey, MD, in her Editorial, "The Charge and the Challenges of Breast Cancer Screening." Collectively, the articles "illustrate the need for a more tailored approach to breast cancer awareness, education, and screening. The goal is to make appropriate screening and diagnosis easier on women and more responsive to the changing face of value-based health care."

"The direct and indirect cost burden of inconclusive mammography screenings and recalls is significant and indicates a need for new approaches to breast cancer screening," says Susan G. Kornstein, MD, Editor-in-Chief of Journal of Women's Health, Executive Director of the Virginia Commonwealth University Institute for Women's Health, Richmond, VA, and President of the Academy of Women's Health.

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The supplement was funded by an educational grant from Hologic, Inc.

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Opportunities to reduce patient burden associated with breast cancer screening

PUBLIC RELEASE DATE:

22-Sep-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

IMAGE: Industrial Biotechnology, led by Co-Editors-in-Chief Larry Walker, PhD, and Glenn Nedwin, PhD, MoT, CEO and President, Taxon Biosciences, Tiburon, CA, is an authoritative journal focused on biobased industrial and environmental...

New Rochelle, NY, September 22, 2014Cassava, also known as tapioca, has large starch-filled roots and can grow at high yields in areas of Africa, Asia, and Latin America where corn and sugarcane are not commonly grown. With the availability of novel enzymes and processes designed to break down tapioca starch into sugars that can then be used to produce sweeteners such as glucose, fructose, or maltose syrup, tapioca may be an ideal alternative to corn, as described in a Review article in Industrial Biotechnology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available for free on the Industrial Biotechnology website.

In the article "Cassava, the Next Corn for Starch Sweeteners", Jay Shetty, DuPont Industrial Biosciences (Palo Alto, CA), Bruce Strohm, Grain Enzyme Technology (Beloit, WI), and Sung Ho Lee and David Bates, and Gang Duan, from DuPont Industrial Biosciences in Cedar Rapids, IA and Wuxi, China, respectively, describe the current geographic distribution of cassava cultivation, and the composition and utility of the starch that comprises 24-30% of the cassava tuber. The authors discuss the variety of enzymes and processing steps available to convert tapioca starch to glucose via liquefaction and saccharification.

"Novel enzyme discovery and development continues to be core to expanding industrial biotechnology opportunities," says Co-Editor-in-Chief Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY.

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About the Journal

Industrial Biotechnology, led by Co-Editors-in-Chief Larry Walker, PhD, and Glenn Nedwin, PhD, MoT, CEO and President, Taxon Biosciences, Tiburon, CA, is an authoritative journal focused on biobased industrial and environmental products and processes, published bimonthly in print and online. The Journal reports on the science, business, and policy developments of the emerging global bioeconomy, including biobased production of energy and fuels, chemicals, materials, and consumer goods. The articles published include critically reviewed original research in all related sciences (biology, biochemistry, chemical and process engineering, agriculture), in addition to expert commentary on current policy, funding, markets, business, legal issues, and science trends. Industrial Biotechnology offers the premier forum bridging basic research and R&D with later-stage commercialization for sustainable biobased industrial and environmental applications.

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Can tapioca replace corn as the main source for starch sweeteners?

How Much Do You Know About GMOs?
Did you know that farmers and gardeners have been genetically modifying their plants to express desired traits through selective breeding for thousands of years? From taste, color and hardiness...

By: KickedUp Media Group

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How Much Do You Know About GMOs? - Video

WARNING: Ebola the Days of Noah - Mass Scale Genetic Engineering of the Human Race
In this radio broadcast, Tim Alberino is interviewed by the fellas from the blogtalkradio program "We Are The Essential Resistance" concerning a conspiracy to conduct mass scale genetic alterations...

By: Genesis 6 Giants (official Steve Quayle channel)

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WARNING: Ebola & the Days of Noah - Mass Scale Genetic Engineering of the Human Race - Video

Bio Farma Speech Entry: The Ethics of Genetic Engineering

By: panji ramdhana

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Bio Farma Speech Entry: The Ethics of Genetic Engineering - Video