Category Archives: DNA

DNA Replication Slideshow!
For Mrs.Torres, AP Biology, 02/27/13. By Kim Peck, Blanca Arriaza, and Remington Ho Prepare to have your mind blown by the sheer amount of information you are about to receive.

By: Blanca Arriaza

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DNA Replication Slideshow! - Video

WOBURN, Mass., Feb. 26, 2013 /PRNewswire/ --Covaris, Inc. introduced the single-tube FFPE DNA Extraction Kit at the 2013 Advances in Genome Biology and Technology (AGBT) meeting held recently in Marco Island, Florida. This newest innovation from Covaris provides an optimized reagent and protocol for high-yield DNA extraction from Formalin-Fixed, Paraffin Embedded (FFPE) tissue samples. Adaptive Focused Acoustic (AFA) Technology is used to emulsify and separate the paraffin, while simultaneously re-hydrating the tissue sample in an aqueous solution within a few minutes. Covaris Focused-ultrasonicators enable the purely mechanical processing of the samples, eliminating the need for organic solvents. Large Molecular Weight DNA is efficiently extracted from FFPE samples, with greater yield when compared to organic extraction with other commercially available kits. The AFA-based kit brings standardization to a previously uncontrolled pre-analytical preparatory step.

The FFPE Nucleic Acid Extraction Kit utilizes AFA Technology, the standard method for DNA fragmentation for Next Generation Sequencing (NGS). An optional DNA fragmentation step can be included in the workflow to precisely size the DNA for applications requiring short DNA fragments, such as NGS all in the same tube. This optional integrated single-tube DNA Shearing streamlines the sample preparation workflow, while also doubling total DNA yield when compared to extraction without fragmentation.

FFPE is a widely used method for archiving tissue specimens; especially clinical samples. Extraction of DNA or RNA from FFPE tissue has traditionally been a challenge as it requires removing the paraffin, rehydrating the sample, and reversing the formaldehyde cross-links, which results in low yields and poor quality of nucleic acid samples. Additionally, the traditional extraction processes require the use of hazardous or difficult-to-handle solvents. Archived FFPE tissues are a rich resource for studying gene variations or gene expression profile changes. This trend has been growing with the continued advances in the fields of genomics and trancriptomics. These new applications benefit from the high-quality starting material and improved workflow provided by the Covaris FFPE DNA Extraction Kit.

About Covaris Covaris, Inc. (www.covarisinc.com) provides advanced sample preparation systems for life and analytical science. Covaris sample prep technologies support a wide variety of applications including Next-Generation Sequencing, ChIP, proteomics, formulations, and compound management. Our patented Adaptive Focused Acoustic (AFA) technology is the industry standard for DNA shearing, and is used by major genome centers, academic, and clinical institutions worldwide. AFA brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, which is based on shock wave physics, delivers controlled, precise, and accurate acoustic energy to biological and chemical samples.

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Covaris introduces a novel FFPE DNA extraction kit at AGBT 2013

LA JOLLA, Calif. and CORALVILLE, Iowa, Feb. 27, 2013 /PRNewswire/ --SGI-DNA, a wholly owned subsidiary of Synthetic Genomics Inc. (SGI), and Integrated DNA Technologies, Inc. (IDT), the world leader in custom oligonucleotide synthesis, today announced an expanded collaboration to develop, manufacture, and market a broad range of synthetic DNA products. Financial details of the agreement were not disclosed.

SGI also announced the official launch of SGI-DNA, which is responsible for all aspects of the development, manufacture, and commercialization of SGI's synthetic DNA technology business. Fernanda Gandara has assumed the role of General Manager for SGI-DNA, and will remain as SGI's Senior Vice President for Business Development.

In February of 2012, IDT and SGI began to co-manufacture and commercialize small synthetic gene products up to 5 kb. IDT also launched its gBlocks Gene Fragments product line, for use in combination with SGI's proprietary DNA technologies, including Gibson Assembly. These IDT and SGI technologies have already revolutionized synthetic biology applications by substantially lowering DNA synthesis costs and by making DNA assembly more efficient and reliable.

IDT and SGI-DNA are now expanding this collaboration to manufacture and co-brand cloned synthetic DNA constructs up to 2 Mbp, a product offering that has never been available until today. This will enable new applications including metabolic and whole genome engineering through de novo DNA synthesis. SGI-DNA is manufacturing the synthetic DNA products and making them available through IDT, and is now IDT's exclusive supplier of the larger DNA constructs. The two companies will also work together on IDT's launch of an expanded gBlocks Gene Fragment offering, expected later in 2013.

"Over the last year, we have grown our in-house gene synthesis business, and effectively worked together with IDT to co-manufacture and commercialize smaller synthetic gene products," said J. Craig Venter, Ph.D., SGI's Founder and Chief Executive Officer. "We are excited about what we will accomplish through the expanded relationship with IDT, which combines SGI-DNA's unique expertise with large, complex gene products and IDT's experience in manufacturing and delivering small DNA products to customers around the globe."

Joseph Walder, Ph.D., IDT's Founder and Chief Executive Officer, agreed. "Through this strengthened collaboration, SGI-DNA and IDT will enable the research community by providing a complete solution, from short genes to very large synthetic constructs, at prices and with delivery times simply unavailable in the market today. Enabling new and better research has always been the essence of IDT's mission, so it's the perfect fit."

For more information about how to order IDT/SGI-DNA products please visit, https://www.idtdna.com/pages/products/genes/custom-gene-synthesis.

About SGI-DNA SGI-DNA, a wholly owned subsidiary of Synthetic Genomics, Inc. (SGI) founded in 2013 and headquartered in La Jolla, CA, provides differentiated synthetic DNA solutions to leading organizations with demands for large and/or complex DNA constructs. Building on the scientific breakthroughs from leading scientists J. Craig Venter, Hamilton Smith, Clyde Hutchison, Dan Gibson and their teams, SGI-DNA utilizes unique and proprietary DNA synthesis technologies from SGI to produce synthetic genes, genetic pathways, and whole genomes quickly and cost-effectively. SGI-DNA is responsible for all commercial aspects of SGI's synthetic DNA business and focuses on strategic business relationships with both academic and commercial researchers. For more information, visit http://www.sgidna.com.

About IDT Integrated DNA Technologies, Inc. (IDT) is the largest supplier of custom synthetic nucleic acids in the world, serving the areas of academic research, biotechnology, clinical diagnostics, and pharmaceutical development. IDT's primary business is the manufacture of custom primers, probes, and genes for research and diagnostic applications. Today, IDT synthesizes and ships an average of 36,000 custom oligos per day to more than 86,000 customers worldwide. IDT's manufacturing locations include facilities in Coralville, Iowa; San Diego, Calif.; Leuven, Belgium; and Singapore. For more information, visit http://www.idtdna.com.

About Synthetic Genomics Inc. SGI, a privately held company founded in 2005, is dedicated to developing and commercializing genomic-driven solutions to address a wide range of global challenges. The company is focused on several key research and business programs including: developing new synthetic DNA products and technologies through SGI-DNA, algae biofuels, new and improved food and nutritional products, and clean water technology. SGI is also involved in synthetically derived vaccine development through Synthetic Genomic Vaccines Inc. (SGVI), a business unit co-founded with the J. Craig Venter Institute; and in developing sustainable crops such as castor and sweet sorghum and agricultural products through AgraCast, a company co-founded with Plenus S.A. de C.V. For more information go to: http://www.syntheticgenomics.com.

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SGI-DNA, a New Subsidiary of Synthetic Genomics Inc., and IDT Announce Broader Collaboration to Develop, Manufacture ...

SCOTUS DNA: Attorney challenges DNA swabbing practices before the US Supreme Court
WASHINGTON. -- The US Supreme Court hears arguments on a Maryland case involving the police and their right to take DNA samples following an arrest.

By: CNS Maryland

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SCOTUS DNA: Attorney challenges DNA swabbing practices before the US Supreme Court - Video

DNA Sampling
Debate on the floor of the state Senate Tuesday that would allow for DNA sampling of those arrested for felonies.

By: gpbweb

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DNA Sampling - Video

Jaguar F Type 2013 DNA Racing Commercial Goodwood HD 2013 Car TV Show

By: BestCarsCommercials

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Jaguar F Type 2013 DNA Racing Commercial Goodwood HD 2013 Car TV Show - Video

SEATTLE--(BUSINESS WIRE)--

DNA Seattle, an independent full-service agency with expertise in brand strategy, advertising, digital strategy and media, today announced the promotion of Pete Hughes from associate creative director to creative director and the hiring of Patrick Mullins as creative director.

Hughes and Mullins will share day-to-day responsibility for DNAs creative work while managing and mentoring art directors, copywriters and graphic designers.

Weve worked with Pete and Patrick off and on over the years, and thats given us a chance to get to know each other pretty well, said Dan Gross, principal and executive creative director at DNA Seattle. They have the smarts, the talent and the temperament to convert on really challenging assignments, and Im confident they can help us grow and lead an outstanding department. I feel really lucky to have them both on board.

Hughes has more than 17 years of experience as a copywriter and creative director at BBDO, FCB, Cole and Weber, and Publicis. His work has received recognition from the British D&AD, Clio, Cannes, Archive and Seattle Show. Since joining DNA Seattle last year, Hughes has been instrumental on several accounts, including Group Health, Trupanion and PowerA/MOGA.

Mullins brings nearly 20 years of award-winning advertising art direction and graphic design experience to DNA, including stints at top creative focused advertising agencies in Seattle, San Francisco, New York and Portland. Prior to joining DNA, Mullins was lead creative director on the national T-Mobile account at Publicis in Seattle. He also created award-winning campaigns for HP, Isuzu and other brands while at Goodby, Silverstein & Partners in San Francisco.

About DNA Seattle

Founded in 1998, DNA is a full-service marketing communications agency based in Seattle, Washington. The agency provides services in brand strategy, advertising, interactive and design. As one of the fastest growing agencies on the West Coast, DNA has a talent and passion for transforming brandsand helping their client partners win unreasoning loyalty from their customers and prospects in the process. Some of DNAs clients include: Group Health Cooperative, PEMCO Insurance, BECU, The Avon Foundation, F5, Executive Travel Magazine, GlobalScholar, Trupanion, MOGA and University of Washington. Visit DNA on the Web atwww.dnaseattle.com, on Twitter at @dnaseattle and on Facebook.

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DNA Seattle Adds Two New Creative Directors with Promotion of Pete Hughes and Hiring of Patrick Mullins

WASHINGTON (Reuters) - In a case that spotlights the growing use of genetic data by law enforcement agencies, the Supreme Court wrestled on Tuesday with the question of when a DNA sample may be taken from a suspect.

The nine justices peppered lawyers for both sides with tough questions during oral argument as they sought to determine what kind of limits should be put on the right of the government to take samples.

Police and prosecutors in Maryland suffered a major setback when the state's Court of Appeals ruled in April 2012 that Alonzo King's Fourth Amendment right to be free from unreasonable search and seizure was violated when he was required to provide his DNA upon being arrested.

Under Maryland law, samples can be taken from anyone arrested for a serious offense without police needing to get a warrant first. Police can then submit those samples to a national database to see if the suspect is linked with any other crimes.

The case argued on Tuesday focuses purely on samples taken without a warrant after a suspect is arrested and charged with a crime, but not convicted of it. Samples taken from convicted felons are routinely submitted to the national database. That practice is not an issue in the case.

The sample King gave after a 2009 arrest in Wicomico County on two assault charges linked him to a 2003 rape. He was sentenced to life in prison after being convicted of the rape and was convicted of one count of misdemeanor assault on the 2009 charges.

His lawyers argue that the sample taken in the assault arrest should not have been used to link him to the rape.

DIVIDED COURT

During the argument, Justice Samuel Alito, a former U.S. attorney, gave the most strident support for the government's right to take DNA.

"I think this is the most important criminal procedure case this court has heard for decades," he said.

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Police use of DNA samples at issue in Supreme Court case

WASHINGTON (Reuters) - In a case that spotlights the growing use of genetic data by law enforcement agencies, the Supreme Court will consider on Tuesday when a DNA sample may be taken from a suspect.

Police and prosecutors in Maryland suffered a major setback when the state's court of appeals ruled in April 2012 that Alonzo King's Fourth Amendment right to be free from unreasonable search and seizure was violated when he was required to provide his DNA upon being arrested.

Under Maryland law, samples can be taken from anyone arrested for a serious offense without police needing to get a warrant first. Police can then submit those samples to a national database to see if the suspect is linked with any other crimes.

The case being argued Tuesday focuses purely on samples taken after a suspect is arrested and charged with a crime, but not convicted of it. Samples taken from convicted felons are routinely submitted to the national database. That practice is not an issue in the case.

The sample King gave after a 2009 arrest in Wicomico County on two assault charges linked him to a 2003 rape. He was sentenced to life in prison after being convicted of the rape and was convicted of one count of misdemeanor assault on the 2009 charges.

His lawyers argue that the sample taken in the assault arrest should not have been used to link him to the rape.

The nine members of the U.S. Supreme Court will review the Maryland court ruling during a one-hour oral argument.

King has received full-throated support from civil liberties groups, which are concerned that the government has too few constraints in collecting DNA. At a minimum, police should be required to get a warrant, based on what lawyers call "individualized suspicion," that links a suspect to a particular crime, King's backers say. There was nothing linking King to the rape until after his DNA was taken and submitted to the database.

Maryland Attorney General Douglas Gansler, a Democrat, said in an interview that the state court decision "didn't make a whole lot of sense to us." He described the law enforcement community in Maryland as being "apoplectic" when the ruling came out.

"The importance of DNA to law enforcement cannot and should not be lost on the justices," Gansler said.

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DNA a civil rights issue in Supreme Court case

The Supreme Court debated Tuesday whether Marylands decision to collect DNA samples from people arrested for serious crimes represents an unconstitutional invasion of privacy or a crime-solving breakthrough with the potential to be the fingerprinting of the 21st century.

Either way, Justice Samuel A. Alito Jr. said, the case is perhaps the most important criminal procedure case that this court has heard in decades.

In this photo taken Oct. 8, 2010, the U.S. Supreme Court justices pose for a group photo at the Supreme Court in Washington.

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Supreme Court weighs DNA ‘fingerprinting’